Overview
My research is based at the Duke Clinical Research Institute, a large academic clinical research organization designed to conduct clinical trials from small local studies to worldwide trials. The focus of my research is bacterial infections: complicated skin and skin structure infections; postoperative wound infections; hospital-acquired and ventilator-associated pneumonia; bacteremia; and endocarditis. Many of these trials are conducted in concert with the pharmaceutical industry in order to register new antibiotics. In addition, as director of infectious diseases at the DCRI I oversee the work of the mycology group, and tuberculosis trials. This work also includes work supported by NIH grants including sepsis trials, the Staph Aureus and Staph Epi Bacteremia Groups, and the International Collaboration of Endocarditis. The team of investigators with whom I work is highly experienced, amazingly productive and wonderfully collegial.
As a result of my longstanding interest in tropical medicine and the generosity of my patients as well as the Hubert Family we have been able to establish the Hubert-Yeargan Center for Global Health. As a result we have developed a medical center-wide fellowship in Global Health. I am presently the Director of the Center and the Gary Hock Distinguished Professor of Global Health.
As a result of my longstanding interest in tropical medicine and the generosity of my patients as well as the Hubert Family we have been able to establish the Hubert-Yeargan Center for Global Health. As a result we have developed a medical center-wide fellowship in Global Health. I am presently the Director of the Center and the Gary Hock Distinguished Professor of Global Health.
Current Appointments & Affiliations
Gary Hock Distinguished Professor Emeritus in Global Health, in the School of Medicine
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2020 - Present
Medicine, Infectious Diseases,
Medicine
Professor Emeritus of Medicine
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2020 - Present
Medicine, Infectious Diseases,
Medicine
Vice-Chair for Education and Global Health in the Department of Medicine
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2011 - Present
Medicine, Infectious Diseases,
Medicine
Recent Publications
A Pooled Analysis of the Safety and Efficacy of Iclaprim Versus Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Patients With Intravenous Drug Use: Phase 3 REVIVE Studies.
Journal Article Clin Ther · June 2019 PURPOSE: This analysis evaluates the efficacy and safety of iclaprim versus vancomycin for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) in patients who were intravenous drug users (IVDUs). METHODS: A total of 621 patients w ... Full text Link to item CiteConsiderations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults.
Journal Article Clin Infect Dis · February 15, 2019 Clinical trials for Staphylococcus aureus bloodstream infections (SAB) are broadly grouped into 2 categories: registrational trials intended to support regulatory approval of antibiotics for the treatment of SAB and strategy trials intended to inform clini ... Full text Link to item CiteSurveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe.
Journal Article Diagn Microbiol Infect Dis · February 2019 Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and surveillance data prior to 2006 suggested that iclaprim was active against Gram-positive pathogens including emerging drug-resistant pathogens. In an era of increasing a ... Full text Link to item CiteRecent Grants
Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria
ResearchAdvisor · Awarded by National Institutes of Health · 2011 - 2022Optimizing treatment for E. faecalis infective endocarditis: ampicillin plus ceftriaxone versus ampicillin plus gentamicin
ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2019Bacteremia Modification 14
Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2009 - 2017View All Grants
Education, Training & Certifications
Baylor University ·
1973
M.D.