Craig Lowe | Scholars@Duke

Craig Lowe
Assistant Professor of Molecular Genetics and Microbiology

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2018
Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

Background
Education, Training, & Certifications
- Ph.D., University of California - Santa Cruz 2010
Recognition
In the News
- NOV 23, 2022
  
  Human Evolution Wasn’t Just the Sheet Music, But How it Was Played
- NOV 9, 2022
  
  Mysterious Outbreak of Bone-Eating TB Resembled an Ancestral Form
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- The Genetic Basis of Macroevolutionary Trends awarded by University of Minnesota 2021 - 2024
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- HARDAC-M: Enabling memory-intensive computation for genomics awarded by North Carolina Biotechnology Center 2020 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
External Relationships
- Alphabet Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Pollen, Alex A., Umut Kilik, Craig B. Lowe, and J Gray Camp. “Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution.” Nat Rev Genet, February 3, 2023, 1–25. https://doi.org/10.1038/s41576-022-00568-4.
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  - Mangan, Riley J., Fernando C. Alsina, Federica Mosti, Jesús Emiliano Sotelo-Fonseca, Daniel A. Snellings, Eric H. Au, Juliana Carvalho, et al. “Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.” Cell 185, no. 24 (November 23, 2022): 4587-4603.e23. https://doi.org/10.1016/j.cell.2022.10.016.
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  - Saelens, Joseph W., Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, et al. “An ancestral mycobacterial effector promotes dissemination of infection.” Cell 185, no. 24 (November 23, 2022): 4507-4525.e18. https://doi.org/10.1016/j.cell.2022.10.019.
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  - Wucherpfennig, Julia I., Timothy R. Howes, Jessica N. Au, Eric H. Au, Garrett A. Roberts Kingman, Shannon D. Brady, Amy L. Herbert, et al. “Evolution of stickleback spines through independent cis-regulatory changes at HOXDB.” Nat Ecol Evol 6, no. 10 (October 2022): 1537–52. https://doi.org/10.1038/s41559-022-01855-3.
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  - Pollen, Alex A., Aparna Bhaduri, Madeline G. Andrews, Tomasz J. Nowakowski, Olivia S. Meyerson, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, et al. “Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.” Cell 176, no. 4 (February 7, 2019): 743-756.e17. https://doi.org/10.1016/j.cell.2019.01.017.
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  - Song, Janet H. T., Craig B. Lowe, and David M. Kingsley. “Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.” Am J Hum Genet 103, no. 3 (September 6, 2018): 421–30. https://doi.org/10.1016/j.ajhg.2018.07.011.
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  - Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Corrigendum: Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 5 (May 2018): 766.1. https://doi.org/10.1101/gr.237370.118.
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  - Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 2 (February 2018): 256–65. https://doi.org/10.1101/gr.206938.116.
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  - Lowe, Craig B., Julia A. Clarke, Allan J. Baker, David Haussler, and Scott V. Edwards. “Feather development genes and associated regulatory innovation predate the origin of Dinosauria.” Mol Biol Evol 32, no. 1 (January 2015): 23–28. https://doi.org/10.1093/molbev/msu309.
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  - Lowe, Craig B., and David Haussler. “29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.” Plos One 7, no. 8 (2012): e43128. https://doi.org/10.1371/journal.pone.0043128.
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  - Lowe, C. B. “Three periods of regulatory innovation during vertebrate evolution (Science (1019)).” Science 334, no. 6057 (November 11, 2011): 761. https://doi.org/10.1126/science.334.6057.761-b.
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  - Lindblad-Toh, Kerstin, Manuel Garber, Or Zuk, Michael F. Lin, Brian J. Parker, Stefan Washietl, Pouya Kheradpour, et al. “A high-resolution map of human evolutionary constraint using 29 mammals.” Nature 478, no. 7370 (October 12, 2011): 476–82. https://doi.org/10.1038/nature10530.
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  - Alföldi, Jessica, Federica Di Palma, Manfred Grabherr, Christina Williams, Lesheng Kong, Evan Mauceli, Pamela Russell, et al. “The genome of the green anole lizard and a comparative analysis with birds and mammals.” Nature 477, no. 7366 (August 31, 2011): 587–91. https://doi.org/10.1038/nature10390.
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  - Lowe, Craig B., Manolis Kellis, Adam Siepel, Brian J. Raney, Michele Clamp, Sofie R. Salama, David M. Kingsley, Kerstin Lindblad-Toh, and David Haussler. “Three periods of regulatory innovation during vertebrate evolution.” Science 333, no. 6045 (August 19, 2011): 1019–24. https://doi.org/10.1126/science.1202702.
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  - Lowe, Craig B., Gill Bejerano, Sofie R. Salama, and David Haussler. “Endangered species hold clues to human evolution.” J Hered 101, no. 4 (July 2010): 437–47. https://doi.org/10.1093/jhered/esq016.
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  - McLean, Cory Y., Dave Bristor, Michael Hiller, Shoa L. Clarke, Bruce T. Schaar, Craig B. Lowe, Aaron M. Wenger, and Gill Bejerano. “GREAT improves functional interpretation of cis-regulatory regions.” Nat Biotechnol 28, no. 5 (May 2010): 495–501. https://doi.org/10.1038/nbt.1630.
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  - Zhu, Jingchun, J Zachary Sanborn, Mark Diekhans, Craig B. Lowe, Tom H. Pringle, and David Haussler. “Comparative genomics search for losses of long-established genes on the human lineage.” Plos Comput Biol 3, no. 12 (December 2007): e247. https://doi.org/10.1371/journal.pcbi.0030247.
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  - Wang, Ting, Jue Zeng, Craig B. Lowe, Robert G. Sellers, Sofie R. Salama, Min Yang, Shawn M. Burgess, Rainer K. Brachmann, and David Haussler. “Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.” Proc Natl Acad Sci U S A 104, no. 47 (November 20, 2007): 18613–18. https://doi.org/10.1073/pnas.0703637104.
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  - Lowe, Craig B., Gill Bejerano, and David Haussler. “Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.” Proc Natl Acad Sci U S A 104, no. 19 (May 8, 2007): 8005–10. https://doi.org/10.1073/pnas.0611223104.
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  - Bejerano, Gill, Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel, Sofie R. Salama, Edward M. Rubin, W James Kent, and David Haussler. “A distal enhancer and an ultraconserved exon are derived from a novel retroposon.” Nature 441, no. 7089 (May 4, 2006): 87–90. https://doi.org/10.1038/nature04696.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

In the News

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Recent Courses