Craig Lowe
Assistant Professor of Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2018
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of California - Santa Cruz 2010
- Recognition
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In the News
- Expertise
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Subject Headings
- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- The Genetic Basis of Macroevolutionary Trends awarded by University of Minnesota 2021 - 2024
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- HARDAC-M: Enabling memory-intensive computation for genomics awarded by North Carolina Biotechnology Center 2020 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
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External Relationships
- Alphabet Inc
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Pollen, Alex A., Umut Kilik, Craig B. Lowe, and J Gray Camp. “Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution.” Nat Rev Genet, February 3, 2023, 1–25. https://doi.org/10.1038/s41576-022-00568-4.Full Text Link to Item
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Mangan, Riley J., Fernando C. Alsina, Federica Mosti, Jesús Emiliano Sotelo-Fonseca, Daniel A. Snellings, Eric H. Au, Juliana Carvalho, et al. “Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.” Cell 185, no. 24 (November 23, 2022): 4587-4603.e23. https://doi.org/10.1016/j.cell.2022.10.016.Full Text Link to Item
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Saelens, Joseph W., Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, et al. “An ancestral mycobacterial effector promotes dissemination of infection.” Cell 185, no. 24 (November 23, 2022): 4507-4525.e18. https://doi.org/10.1016/j.cell.2022.10.019.Full Text Link to Item
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Wucherpfennig, Julia I., Timothy R. Howes, Jessica N. Au, Eric H. Au, Garrett A. Roberts Kingman, Shannon D. Brady, Amy L. Herbert, et al. “Evolution of stickleback spines through independent cis-regulatory changes at HOXDB.” Nat Ecol Evol 6, no. 10 (October 2022): 1537–52. https://doi.org/10.1038/s41559-022-01855-3.Full Text Link to Item
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Pollen, Alex A., Aparna Bhaduri, Madeline G. Andrews, Tomasz J. Nowakowski, Olivia S. Meyerson, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, et al. “Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.” Cell 176, no. 4 (February 7, 2019): 743-756.e17. https://doi.org/10.1016/j.cell.2019.01.017.Full Text Link to Item
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Song, Janet H. T., Craig B. Lowe, and David M. Kingsley. “Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.” Am J Hum Genet 103, no. 3 (September 6, 2018): 421–30. https://doi.org/10.1016/j.ajhg.2018.07.011.Full Text Link to Item
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Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Corrigendum: Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 5 (May 2018): 766.1. https://doi.org/10.1101/gr.237370.118.Full Text Link to Item
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Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 2 (February 2018): 256–65. https://doi.org/10.1101/gr.206938.116.Full Text Open Access Copy Link to Item
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Lowe, Craig B., Julia A. Clarke, Allan J. Baker, David Haussler, and Scott V. Edwards. “Feather development genes and associated regulatory innovation predate the origin of Dinosauria.” Mol Biol Evol 32, no. 1 (January 2015): 23–28. https://doi.org/10.1093/molbev/msu309.Full Text Open Access Copy Link to Item
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Lowe, Craig B., and David Haussler. “29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.” Plos One 7, no. 8 (2012): e43128. https://doi.org/10.1371/journal.pone.0043128.Full Text Open Access Copy Link to Item
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Lowe, C. B. “Three periods of regulatory innovation during vertebrate evolution (Science (1019)).” Science 334, no. 6057 (November 11, 2011): 761. https://doi.org/10.1126/science.334.6057.761-b.Full Text
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Lindblad-Toh, Kerstin, Manuel Garber, Or Zuk, Michael F. Lin, Brian J. Parker, Stefan Washietl, Pouya Kheradpour, et al. “A high-resolution map of human evolutionary constraint using 29 mammals.” Nature 478, no. 7370 (October 12, 2011): 476–82. https://doi.org/10.1038/nature10530.Full Text Open Access Copy Link to Item
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Alföldi, Jessica, Federica Di Palma, Manfred Grabherr, Christina Williams, Lesheng Kong, Evan Mauceli, Pamela Russell, et al. “The genome of the green anole lizard and a comparative analysis with birds and mammals.” Nature 477, no. 7366 (August 31, 2011): 587–91. https://doi.org/10.1038/nature10390.Full Text Open Access Copy Link to Item
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Lowe, Craig B., Manolis Kellis, Adam Siepel, Brian J. Raney, Michele Clamp, Sofie R. Salama, David M. Kingsley, Kerstin Lindblad-Toh, and David Haussler. “Three periods of regulatory innovation during vertebrate evolution.” Science 333, no. 6045 (August 19, 2011): 1019–24. https://doi.org/10.1126/science.1202702.Full Text Open Access Copy Link to Item
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Lowe, Craig B., Gill Bejerano, Sofie R. Salama, and David Haussler. “Endangered species hold clues to human evolution.” J Hered 101, no. 4 (July 2010): 437–47. https://doi.org/10.1093/jhered/esq016.Full Text Open Access Copy Link to Item
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McLean, Cory Y., Dave Bristor, Michael Hiller, Shoa L. Clarke, Bruce T. Schaar, Craig B. Lowe, Aaron M. Wenger, and Gill Bejerano. “GREAT improves functional interpretation of cis-regulatory regions.” Nat Biotechnol 28, no. 5 (May 2010): 495–501. https://doi.org/10.1038/nbt.1630.Full Text Open Access Copy Link to Item
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Zhu, Jingchun, J Zachary Sanborn, Mark Diekhans, Craig B. Lowe, Tom H. Pringle, and David Haussler. “Comparative genomics search for losses of long-established genes on the human lineage.” Plos Comput Biol 3, no. 12 (December 2007): e247. https://doi.org/10.1371/journal.pcbi.0030247.Full Text Link to Item
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Wang, Ting, Jue Zeng, Craig B. Lowe, Robert G. Sellers, Sofie R. Salama, Min Yang, Shawn M. Burgess, Rainer K. Brachmann, and David Haussler. “Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.” Proc Natl Acad Sci U S A 104, no. 47 (November 20, 2007): 18613–18. https://doi.org/10.1073/pnas.0703637104.Full Text Open Access Copy Link to Item
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Lowe, Craig B., Gill Bejerano, and David Haussler. “Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.” Proc Natl Acad Sci U S A 104, no. 19 (May 8, 2007): 8005–10. https://doi.org/10.1073/pnas.0611223104.Full Text Open Access Copy Link to Item
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Bejerano, Gill, Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel, Sofie R. Salama, Edward M. Rubin, W James Kent, and David Haussler. “A distal enhancer and an ultraconserved exon are derived from a novel retroposon.” Nature 441, no. 7089 (May 4, 2006): 87–90. https://doi.org/10.1038/nature04696.Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
- UPGEN 778A: University Program in Genetics and Genomics Biological Solutions Module I 2023
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2022
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2021
- UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill 2021
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