Craig Lowe | Scholars@Duke

Craig Lowe
Assistant Professor of Molecular Genetics and Microbiology

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

Background
Education, Training, & Certifications
- Ph.D., University of California - Santa Cruz 2010
Research
Selected Grants
- From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- HARDAC-M: Enabling memory-intensive computation for genomics awarded by North Carolina Biotechnology Center 2020 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
External Relationships
- Alphabet Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Pollen, Alex A., Aparna Bhaduri, Madeline G. Andrews, Tomasz J. Nowakowski, Olivia S. Meyerson, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, et al. “Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.” Cell 176, no. 4 (February 7, 2019): 743-756.e17. https://doi.org/10.1016/j.cell.2019.01.017.
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  - Song, Janet H. T., Craig B. Lowe, and David M. Kingsley. “Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia.” Am J Hum Genet 103, no. 3 (September 6, 2018): 421–30. https://doi.org/10.1016/j.ajhg.2018.07.011.
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  - Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Corrigendum: Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 5 (May 2018): 766.1. https://doi.org/10.1101/gr.237370.118.
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  - Lowe, Craig B., Nicelio Sanchez-Luege, Timothy R. Howes, Shannon D. Brady, Rhea R. Daugherty, Felicity C. Jones, Michael A. Bell, and David M. Kingsley. “Detecting differential copy number variation between groups of samples.” Genome Res 28, no. 2 (February 2018): 256–65. https://doi.org/10.1101/gr.206938.116.
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  - Lowe, Craig B., Julia A. Clarke, Allan J. Baker, David Haussler, and Scott V. Edwards. “Feather development genes and associated regulatory innovation predate the origin of Dinosauria.” Mol Biol Evol 32, no. 1 (January 2015): 23–28. https://doi.org/10.1093/molbev/msu309.
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  - Lowe, Craig B., and David Haussler. “29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.” Plos One 7, no. 8 (2012): e43128. https://doi.org/10.1371/journal.pone.0043128.
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  - Lowe, C. B. “Three periods of regulatory innovation during vertebrate evolution (Science (1019)).” Science 334, no. 6057 (November 11, 2011): 761. https://doi.org/10.1126/science.334.6057.761-b.
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  - Lindblad-Toh, Kerstin, Manuel Garber, Or Zuk, Michael F. Lin, Brian J. Parker, Stefan Washietl, Pouya Kheradpour, et al. “A high-resolution map of human evolutionary constraint using 29 mammals.” Nature 478, no. 7370 (October 12, 2011): 476–82. https://doi.org/10.1038/nature10530.
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  - Alföldi, Jessica, Federica Di Palma, Manfred Grabherr, Christina Williams, Lesheng Kong, Evan Mauceli, Pamela Russell, et al. “The genome of the green anole lizard and a comparative analysis with birds and mammals.” Nature 477, no. 7366 (August 31, 2011): 587–91. https://doi.org/10.1038/nature10390.
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  - Lowe, Craig B., Manolis Kellis, Adam Siepel, Brian J. Raney, Michele Clamp, Sofie R. Salama, David M. Kingsley, Kerstin Lindblad-Toh, and David Haussler. “Three periods of regulatory innovation during vertebrate evolution.” Science 333, no. 6045 (August 19, 2011): 1019–24. https://doi.org/10.1126/science.1202702.
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  - Lowe, Craig B., Gill Bejerano, Sofie R. Salama, and David Haussler. “Endangered species hold clues to human evolution.” J Hered 101, no. 4 (July 2010): 437–47. https://doi.org/10.1093/jhered/esq016.
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  - McLean, Cory Y., Dave Bristor, Michael Hiller, Shoa L. Clarke, Bruce T. Schaar, Craig B. Lowe, Aaron M. Wenger, and Gill Bejerano. “GREAT improves functional interpretation of cis-regulatory regions.” Nat Biotechnol 28, no. 5 (May 2010): 495–501. https://doi.org/10.1038/nbt.1630.
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  - Zhu, Jingchun, J Zachary Sanborn, Mark Diekhans, Craig B. Lowe, Tom H. Pringle, and David Haussler. “Comparative genomics search for losses of long-established genes on the human lineage.” Plos Comput Biol 3, no. 12 (December 2007): e247. https://doi.org/10.1371/journal.pcbi.0030247.
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  - Wang, Ting, Jue Zeng, Craig B. Lowe, Robert G. Sellers, Sofie R. Salama, Min Yang, Shawn M. Burgess, Rainer K. Brachmann, and David Haussler. “Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.” Proc Natl Acad Sci U S A 104, no. 47 (November 20, 2007): 18613–18. https://doi.org/10.1073/pnas.0703637104.
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  - Lowe, Craig B., Gill Bejerano, and David Haussler. “Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.” Proc Natl Acad Sci U S A 104, no. 19 (May 8, 2007): 8005–10. https://doi.org/10.1073/pnas.0611223104.
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  - Bejerano, Gill, Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel, Sofie R. Salama, Edward M. Rubin, W James Kent, and David Haussler. “A distal enhancer and an ultraconserved exon are derived from a novel retroposon.” Nature 441, no. 7089 (May 4, 2006): 87–90. https://doi.org/10.1038/nature04696.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Selected Grants

External Relationships

Selected Publications

Academic Articles

Recent Courses