James D. Crapo
Consulting Professor in the Department of Medicine

The primary laboratory focus is on the role of oxygen-based free radicals in mediating acute and chronic lung injury. The role of superoxide dismutases and, in particular, the extracellular form of superoxide dismutase in modulating oxidant-mediated tissue injury is being explored. We are developing small molecule mimetics of superoxide dismutases and targeting them to specific cells or to extracellular compartments. The efficacy of these SOD mimetics is being tested in a number of in vitro and in vivo models including tracheal and vascular rings and mouse and rat models of acute lung injury. Oxygen toxicity, paraquat-induced lung injury and antigen-induced lung injury are the most common models used. The laboratory also investigates the effects of inhaled air pollutants (e.g., ozone, nitrogen dioxide, and particulates) on lung structure and function. This laboratory utilizes cell biology, molecular biology, electron microscopy, morphometry and immunochemical techniques to study these problems in an interdisciplinary fashion.

Key Words: Superoxide dismutases, inhalation toxicology, morphometry.

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