Cristian Tudorel Badea

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 2, 2026 The simultaneous multi-energy capability of photon-counting detectors (PCDs) enables CT imaging with multiple contrast agents, which is particularly valuable for preclinical cancer studies such as photon-counting CT (PCCT) imaging of mouse models of head a ... Full text Cite

Advancing deep learning denoising methods with self-supervised training and multi-channel image priors

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 2, 2026 Supervised deep learning methods have saturated nearly every step of medical imaging data acquisition and reconstruction pipelines, complementing older numerical methods and physics-informed prior information with a new generation of data-specific prior in ... Full text Cite

Investigating brain-heart interactions using resting-state fMRI and photon-counting micro-CT in aged APOE mice

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 1, 2026 Understanding the interplay between brain and heart function is critical for mapping systemic aging and risk for neurodegenerative and cardiovascular diseases. We combined resting-state functional MRI (rs-fMRI) and photon-counting computed tomography (PCCT ... Full text Cite

High-Resolution 5D Cardiac Photon-Counting Micro-CT in Mice Using a Fast Turntable Scanner and Deep Learning-Based Full Heart Segmentation

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 1, 2026 Preclinical 5D (3 spatial dimensions + energy + time) in vivo photon-counting micro-CT (PCCT) imaging enables cardiac phenotyping in humanized mouse models of cardiovascular disease risk. Our group has previously used 5D cardiac PCCT imaging of mice and a ... Full text Cite

High-Resolution Micro-CT Imaging Protocols for Studies of Intracranial Aneurysms in Murine Models

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Unruptured intracranial aneurysms (UIAs) pose significant clinical challenges due to their risk of growth and rupture. Early and accurate imaging is essential for effective management and understanding their pathophysiology. This study integrates three adv ... Full text Cite

Development of a Virtual Photon-Counting Micro-CT Imaging Platform for Preclinical Cancer Studies

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Micro-CT imaging studies in mouse cancer models are vital for developing therapeutics. Multi-energy CT imaging with a photon-counting detector (PCD) improves material separation in cancer studies involving nanoparticle-based contrast agents and combination ... Full text Cite

Quantitative Comparison of Femurs in Apolipoprotein E Mouse Models using High Resolution Photon-Counting Micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Apolipoprotein E (APOE) genotype and nitric oxide synthase 2 (NOS2) expression are key genetic factors that influence bone health. While prior studies explored differences in bones by APOE genotype, the role of sex and NOS2 require further investigation. I ... Full text Cite

Deep learning micro-CT perfusion quantification

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 This study investigates the use of a convolutional neural network to perform micro-CT perfusion quantification. Perfusion CT has demonstrated substantial benefits in human medicine, being widely used for assessing cerebral blood flow in stroke patients, ev ... Full text Cite

A deep-learning reconstruction framework for low-dose, dynamic x-ray CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Decades of x-ray CT research focuses on iterative reconstruction and denoising methods to alleviate constraints on data sampling and ionizing radiation dose. In particular, multi-channel CT imaging applications (multienergy, dynamic) remain an active area ... Full text Cite

A perfusion phantom for dynamic micro-CT imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 This study presents the development, implementation, and testing of a 3D printed phantom with two compartments designed for dynamic micro-CT imaging using low molecular weight contrast agents. The phantom was evaluated through both optical and micro-CT ima ... Full text Cite

Exploring VivoVist™ for Ex Vivo Micro-CT Imaging of Mouse Vasculature

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 This study aims to develop a simpler, quicker, and more effective method for ex vivo vascular imaging using VivoVist™, a barium-based micro-CT contrast agent, combined with an anticoagulant. VivoVist™ (Nanoprobes, Inc.) is a commercially available contrast ... Full text Cite

Photon counting micro-CT imaging of Bi2WO6 nanoparticles

Conference Medical Imaging 2024: Clinical and Biomedical Imaging · April 2, 2024 Full text Open Access Cite

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Conference Medical Imaging 2024: Clinical and Biomedical Imaging · April 2, 2024 Full text Open Access Cite

Predicting brain age and associated structural networks in mouse models with humanized APOE alleles using integrative and interpretable graph neural networks

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is influenced by an intricate mix of risk factors including age, genetics, and environmental variables. In our study, we employed mouse models with human APOE alleles and nitric oxide syntha ... Full text Cite

Multi-Channel Reconstruction (MCR) Toolkit v2.0: open-source Python-based tools for X-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Recently, we have released the first open-source version of our Multi-Channel CT Reconstruction (MCR) Toolkit (https://gitlab.oit.duke.edu/dpc18/mcr-toolkit-public). The initial release of the Toolkit represents 10 years of development and provides a compl ... Full text Cite

Advancing Preclinical Micro-Photon Counting CT Perfusion Imaging: From Phantom Experiments to In Vivo Applications

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 In preclinical studies, micro-CT is frequently employed to yield valuable anatomical insights. However, there has been an increasing need for micro-CT in extracting functional measurements such as with perfusion imaging. Perfusion imaging plays a crucial r ... Full text Cite

Denoising pediatric cardiac photon-counting CT data using volumetric vision transformers and unpaired training data

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 The advent of clinical photon counting x-ray CT (PCCT) has yielded gains in spatial resolution, noise performance, contrast resolution, and radiation dose management in numerous diagnostic applications. Pediatric populations, especially, stand to benefit f ... Full text Cite

Deep Learning Models for Rapid Denoising of 5D Cardiac Photon-Counting Micro-CT Images

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) are advantageous for spectral CT imaging and material decomposition because they simultaneously acquire projections at multiple energies using energy thresholds. Unfortunately, the PCD produces noisy weighted filtered backp ... Full text Cite

An Acquisition-Based Approach for High-Fidelity Infilling of Photon-Counting X-ray Detector Pixel Gaps

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Photon-counting detectors (PCDs) represent a technological advancement in X-ray CT imaging, bringing increased spatial resolution and spectral information to imaging in medical and industrial fields. Despite their potential, a critical issue arises from de ... Full text Cite

Unsupervised learning of robust models for cardiac and photon-counting x-ray CT denoising

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2023 Supervised deep learning methods have rapidly advanced to the forefront of medical imaging research; however, they face limitations in advanced CT applications. For instance, label generation is difficult for retrospective cardiac CT data where dose modula ... Full text Cite

Spectral micro-CT imaging of multiple K-edge elements using GaAs and CdTe photon counting detectors

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2023 Superior material discrimination provided by photon counting detector (PCD) technology promises to transform X-ray CT into a functional and molecular imaging modality while maintaining its high spatial resolution, fast scanning times, and relatively low co ... Full text Cite

Ex vivo high-resolution hybrid micro-CT imaging using photon counting and energy integrating detectors

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2023 Spectral micro-CT shows great potential to provide accurate material composition by utilizing the energy dependence of x-ray attenuation in different materials. This is especially well-suited for pre-clinical imaging using nanoparticle-based contrast agent ... Full text Cite

Cardiac CT reconstruction for vendor-neutral virtual imaging trials

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 Cardiac CT imaging is invaluable in a variety of applications including non-invasive assessment of coronary artery calcifications, the ruling out of acute coronary artery syndrome, and the planning of valve replacement procedures. Newer applications includ ... Full text Cite

Photon Counting Micro-CT for Imaging Cisplatin

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 The photon-counting (PC) detector technology promises to enhance the number of CT applications due to the spectral information. Of high interest for the cancer research community is imaging the tumor delivery of Cisplatin (CisPt), a chemotherapeutic agent ... Full text Cite

Spectral micro-CT and nanoradiomic analysis for classification of tumors based on lymphocytic burden in cancer therapy studies

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 The purpose of this study was to investigate if radiomic analysis based on spectral micro-CT with nanoparticle contrast-enhancement can differentiate tumors based on tumor-infiltrating lymphocyte (TIL) burden. High mutational load transplant soft tissue sa ... Full text Cite

Volumetric, dual-domain x-ray CT reconstruction with deep learning

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 Novel deep learning (DL) methods have produced state-of-the-art results in nearly every area of x-ray CT data processing. However, DL-driven, iterative reconstruction remains challenging because of the volumetric nature of many reconstruction problems: the ... Full text Cite

Anatomical and functional cardiac PCCT imaging pipeline for characterization of Apolipoprotein E mouse models

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 Non-invasive imaging strategies are essential in understanding the factors associated with the ongoing rise in cardiovascular disease (CVD) and Alzheimer’s disease (AD), and the possible interactions between these diseases. Our scientific premise is based ... Full text Cite

Co-clinical photon counting CT research for multi-contrast imaging

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2022 Developing novel contrast agents for multi-energy photon-counting (PC)CT will require a clear translation pathway from preclinical validation to clinical applications. To begin this development, we have used a clinical PCCT scanner (Siemens NAEOTOM Alpha) ... Full text Cite

Photon-counting X-ray CT perfusion imaging in animal models of cancer

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2022 Photon-counting detector (PCD) CT promises to improve routine CT imaging applications with higher spatial resolution, lower levels of noise at fixed dose, and improved image contrast while providing spectral information with every scan. We propose and demo ... Full text Cite

Material Decomposition from Photon-Counting CT using a Convolutional Neural Network and Energy-Integrating CT Training Labels

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2022 Although photon counting detectors (PCD) can offer numerous benefits for CT imaging, it is difficult to generate accurate material decompositions from photon counting (PC) CT images due to spectral distortions. In this work, we present a deep learning (DL) ... Full text Cite

Deep learning based spectral distortion correction and decomposition for photon counting ct using calibration provided by an energy integrated detector

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2021 While the benefits of photon counting (PC) CT are significant, the performance of current PCDs is limited by physical effects distorting the spectral response. In this work, we examine a deep learning (DL) approach for spectral correction and material deco ... Full text Cite

A constrained bregman framework for unsupervised convolutional denoising of multi-channel x-ray ct data

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2021 Deep learning (DL) approaches to image denoising have advanced real-world performance in one of the most thoroughly studied areas of digital signal processing. Keys to the success of DL are data-driven approximation of an underlying signal model and non-li ... Full text Cite

Towards deep learning detection of lung nodules using micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2021 We are developing imaging methods for the preclinical arm of a co-clinical trial investigating synergy between immunotherapy and radiotherapy. We perform in vivo micro-CT of mouse lungs to detect lung metastasis after treatment. This work explores deep lea ... Full text Cite

Hybrid energy integrating and photon counting micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 The maturation of photon-counting detector (PCD) technology promises to enhance routine CT applications with high-fidelity spectral information, transforming X-ray CT into a functional and molecular imaging modality, while maintaining the high spatial reso ... Full text Cite

Fast spectral x-ray CT reconstruction with data-adaptive, convolutional regularization

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 Advancements in deep learning and GPU computing have exponentially driven the application of neural networks to classic medical imaging problems: denoising, segmentation, artifact removal, etc. Deep learning solutions are particularly attractive for proces ... Full text Cite

Development of a spectral Micro-CT system using a photon counting detector with anti-coincidence corrections

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 There is potential to improve CT imaging by adding spectral capabilities as given by photon counting detectors (PCD). Here we describe and assess performance of a new spectral micro-CT prototype system using a CdTe-based PCD with 100-µm pixel size (model X ... Full text Cite

MRI-based radiomics of sarcomas in the preclinical arm of a Co-clinical trial

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 Radiomics provide an exciting approach to developing imaging biomarkers in the context of precision medicine. We focus on the preclinical arm of a co-clinical trial investigating synergy of immunotherapy combined with radiation therapy (RT) and surgical re ... Full text Cite

A spectral CT study on iodine augmentation of radiation therapy and its potential for combination with chemotherapy

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 High-Z based nanoparticles (NP) are emerging as promising agents for both cancer radiotherapy (RT) and CT imaging. NPs can be delivered to tumors via the enhanced permeability and retention (EPR) effect and they preferentially accumulate in tumor's perivas ... Full text Cite

To gate or not to gate: An evaluation of respiratory gating techniques to improve volume measurement of murine lung tumors in micro-CT imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging is faced with unique challenges that emphasize the gap between mouse and man. One exam ... Full text Cite

Multi-modal MRI segmentation of sarcoma tumors using convolutional neural networks

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019 Small animal imaging is essential in building a bridge from basic science to the clinic by providing the confidence necessary to move new cancer therapies to patients. However, there is considerable variability in preclinical imaging, including tumor volum ... Full text Cite

Spectral data completion for dual-source x-ray CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019 In the context of x-ray CT, data completion is the process of augmenting truncated projection data to avoid artifacts during reconstruction. Data completion is commonly employed in dual-source CT where physical or hardware constraints limit the field of vi ... Full text Cite

Convolutional regularization methods for 4D, x-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2019 Deep learning methods have shown great promise in tackling challenging medical imaging tasks. Within the field of x-ray CT, deep learning for image denoising is of interest because of the fundamental link between ionizing radiation dose and diagnostic imag ... Full text Cite

Data-efficient methods for multi-channel x-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 The superiority of iterative reconstruction techniques over analytical ones is documented in a variety of CT imaging applications. However, iterative reconstruction techniques generally require a substantial increase in data processing time and required re ... Full text Cite

Multiscale dual energy micro-CT for imaging using iodinated and gold nanoparticles

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Dual energy (DE) micro-CT shows great potential to provide accurate tissue composition by utilizing the energy dependence of x-ray attenuation in different materials. This is especially well-suited for pre-clinical imaging using nanoparticle-based contrast ... Full text Cite

Multi-energy CT decomposition using convolutional neural networks

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Spectral CT can provide accurate tissue composition measurements by utilizing the energy dependence of x-ray attenuation in different materials. We have introduced image reconstruction and material decomposition algorithms for multi-energy CT data acquired ... Full text Cite

Spectral imaging of iodine and gadolinium nanoparticles using dual-energy CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Advances in CT hardware have propelled the development of novel CT contrast agents. Combined with the spectral capabilities of X-ray CT, molecular imaging is possible using multiple heavy-metal contrast agents. Nanoparticle platforms make particularly attr ... Full text Cite

Development of a spectral photon-counting micro-CT system with a translate-rotate geometry

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2018 Spectral CT using photon counting x-ray detectors (PCXDs) can provide accurate tissue composition measurements by utilizing the energy dependence of x-ray attenuation in different materials. PCXDs are especially suited for imaging Kedge contrast agents, re ... Full text Cite

A data-driven regularization strategy for statistical CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017 There is an unmet need for CT image reconstruction algorithms that reliably provide diagnostic image quality at reduced radiation dose. Toward this end, we integrate a state-of-the-art statistical reconstruction algorithm, ordered subsets, and separable qu ... Full text Cite

Localized and efficient cardiac CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017 The superiority of iterative reconstruction techniques over classic analytical ones is well documented in a variety of CT imaging applications where radiation dose and sampling time are limiting factors. However, by definition, the iterative nature of adva ... Full text Cite

Low-dose 4D myocardial perfusion with x-ray micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2017 X-ray CT is widely used, both clinically and pre-clinically, for fast, high-resolution, anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. For instance, temporally-resolved CT data can detail car ... Full text Cite

A dual energy CT study on vascular effects of gold nanoparticles in radiation therapy

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and CT imaging. AuNPs are delivered to tumors via the enhanced permeability and retention effect and they preferentially accumulate in close proximity to the tumor blood ve ... Full text Cite

Resolution-enhancing hybrid, spectral CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 Spectral x-ray imaging based on photon-counting x-ray detectors (PCXD) is an area of growing interest. By measuring the energy of x-ray photons, a spectral CT system can better differentiate elements using a single scan. However, the spatial resolution ach ... Full text Cite

Joint regularization for spectrooral CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 X-ray CT is widely used, both clinically and preclinically, for fast, high-resolution, anatomic imaging; however, compelling opportunities exist to expand its use in functional imaging applications. For instance, spectral information combined with nanopart ... Full text Cite

Novel approaches to address spectral distortions in photon counting x-ray CT using artificial neural networks

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 Spectral CT using a photon-counting x-ray detector (PCXD) can potentially increase accuracy of measuring tissue composition. However, PCXD spectral measurements suffer from distortion due to charge sharing, pulse pileup, and Kescape energy loss. This study ... Full text Cite

Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2015 Relative to prospective projection gating, retrospective projection gating for dynamic CT applications allows fast imaging times, minimizing the potential for physiological and anatomic variability. Preclinically, fast imaging is attractive due to the rapi ... Full text Cite

Spectral deblurring: An algorithm for high-resolution, hybrid spectral CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2015 We are developing a hybrid, dual-source micro-CT system based on the combined use of an energy integrating (EID) x-ray detector and a photon counting x-ray detector (PCXD). Due to their superior spectral resolving power, PCXDs have the potential to reduce ... Full text Cite

Simultaneous imaging of multiple contrast agents using full-spectrum micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2015 One of the major challenges for in vivo, micro-computed tomography (CT) imaging is poor soft tissue contrast. To increase contrast, exogenous contrast agents can be used as imaging probes. Combining these probes with a photon counting x-ray detector (PCXD) ... Full text Cite

Rank-sparsity constrained atlas construction and phenotyping

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2015 Atlas construction is of great interest in the medical imaging community as a tool to visually and quantitatively characterize anatomic variability within a population. Because such atlases generally exhibit superior data fidelity relative to the individua ... Full text Cite

Helical dual source cone-beam micro-CT

Conference 2014 IEEE 11th International Symposium on Biomedical Imaging Isbi 2014 · July 29, 2014 While helical scanning is well established in the clinical arena, most micro-CT scanners use circular cone beam trajectories and approximate reconstructions based on a filtered backprojection (FBP) algorithm. This may be sufficient for some applications, b ... Full text Cite

A multi-resolution approach to retrospectively-gated cardiac micro-CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014 In preclinical research, micro-CT is commonly used to provide anatomical information; however, there is significant interest in using this technology to obtain functional information in cardiac studies. The fastest acquisition in 4D cardiac micro-CT imagin ... Full text Cite

Robust material decomposition for spectral CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014 There is ongoing interest in extending CT from anatomical to functional imaging. Recent successes with dual energy CT, the introduction of energy discriminating x-ray detectors, and novel, target-specific, nanoparticle contrast agents enable functional ima ... Full text Cite

Dual-energy micro-CT imaging of pulmonary airway obstruction: Correlation with micro-SPECT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2014 To match recent clinical dual energy (DE) CT studies focusing on the lung, similar developments for DE micro-CT of the rodent lung are required. Our group has been actively engaged in designing pulmonary gating techniques for micro- CT, and has also introd ... Full text Cite

The effect of scatter correction on dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · June 3, 2013 Dual energy (DE) CT imaging is expected to play a major role in the diagnostic arena as it provides a quantitative decomposition of basis materials, opening the door for new clinical applications without significantly increasing dose to the patient. DE-CT ... Full text Cite

A comparison of sampling strategies for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · May 4, 2012 Micro-CT has become a powerful tool for small animal research. Many micro-CT applications require exogenous contrast agents, which are most commonly based on iodine. Despite advancements in contrast agents, single-energy micro-CT is sometimes limited in th ... Full text Cite

Denoising of 4D Cardiac Micro-CT Data Using Median-Centric Bilateral Filtration.

Conference Proc SPIE Int Soc Opt Eng · February 23, 2012 Featured Work Bilateral filtration has proven an effective tool for denoising CT data. The classic filter utilizes Gaussian domain and range weighting functions in 2D. More recently, other distributions have yielded more accurate results in specific applications, and th ... Full text Link to item Cite

Investigations on X-ray luminescence CT for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · 2012 Featured Work X-ray Luminescence CT (XLCT) is a hybrid imaging modality combining x-ray and optical imaging in which x-ray luminescent nanophosphors (NPs) are used as emissive imaging probes. NPs are easily excited using common CT energy x-ray beams, and the NP luminesc ... Full text Link to item Cite

Dual-energy micro-CT imaging for differentiation of iodine- and gold-based nanoparticles

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · May 13, 2011 Spectral CT imaging is expected to play a major role in the diagnostic arena as it provides material decomposition on an elemental basis. One fascinating possibility is the ability to discriminate multiple contrast agents targeting different biological sit ... Full text Cite

Synthesis of epitaxial BaZrO3 thin films by chemical solution deposition

Conference Thin Solid Films · June 2010 Full text Cite

GPU-based iterative reconstruction with total variation minimization for micro-CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · 2010 Dynamic imaging with micro-CT often produces poorly-distributed sets of projections, and reconstructions of this data with filtered backprojection algorithms (FBP) may be affected by artifacts. Iterative reconstruction algorithms and total variation (TV) d ... Full text Cite

Free-space fluorescence tomography with adaptive sampling based on anatomical information from microCT.

Conference Proc SPIE Int Soc Opt Eng · 2010 Featured Work Image reconstruction is one of the main challenges for fluorescence tomography. For in vivo experiments on small animals, in particular, the inhomogeneous optical properties and irregular surface of the animal make free-space image reconstruction challengi ... Full text Link to item Cite

Dissecting the Mechanism of Tumor Response to Radiation Therapy with Primary Lung Cancers in Mice

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

In Vivo shRNA to Study the Molecular Mechanisms of Radiation Response of Primary Cancers in Mice

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

A material decomposition method for dual energy micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · June 15, 2009 The attenuation of x-rays in matter is dependent on the energy of the x-rays and the atomic composition of the matter. Attenuation measurements at multiple x-ray energies can be used to improve the identification of materials. We present a method to estima ... Full text Cite

4D micro-CT-based perfusion imaging in small animals

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · June 15, 2009 Quantitative in-vivo imaging of lung perfusion in rodents can provide critical information for preclinical studies. However, the combined challenges of high temporal and spatial resolution have made routine quantitative perfusion imaging difficult in roden ... Full text Cite

Development of a noncontact 3-D fluorescence tomography system for small animal in vivo imaging.

Conference Proc SPIE Int Soc Opt Eng · February 16, 2009 Featured Work Fluorescence imaging is an important tool for tracking molecular-targeting probes in preclinical studies. It offers high sensitivity, but nonetheless low spatial resolution compared to other leading imaging methods such CT and MRI. We demonstrate our metho ... Full text Link to item Cite

Dye-sensitized solar cells based on nanocrystalline TiO2 and natural pigments

Conference JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIALS · November 1, 2008 Link to item Cite

Time-Dependent Diffusion Studies on Miglyol Molecules Confined in Permeable Polymeric Capsules

Conference Applied Magnetic Resonance · July 2008 Full text Cite

A dual micro-CT system for small animal imaging.

Conference Proc SPIE Int Soc Opt Eng · April 18, 2008 Featured Work Micro-CT is a non-invasive imaging modality usually used to assess morphology in small animals. In our previous work, we have demonstrated that functional micro-CT imaging is also possible. This paper describes a dual micro-CT system with two fixed x-ray/d ... Full text Link to item Cite

TH‐C‐351‐02: Registration Based Automatic Segmentation and Wall Motion Analysis for 4D Cardiac Micro‐CT in Mice

Conference Medical Physics · January 1, 2008 Purpose: We present an automated method for segmentation and tracking of hearth anatomy using 4D cardiac micro‐CT datasets in mice. Cardiac motion is determined and analyzed using the deformation field obtained after non‐rigidly deforming a template to all ... Full text Cite

Measurement and modeling of 4D live mouse heart volumes from CT time series

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2007 In vivo quantitative studies of cardiac function in mouse models provide information about cardiac pathophysiology in more detail than can be obtained in humans. Quantitative measurements of left ventricular (LV) volume at multiple contractile phases are p ... Full text Cite

Functional imaging in small animals using tomographic digital subtraction angiography

Conference 2006 3rd IEEE International Symposium on Biomedical Imaging from Nano to Macro Proceedings · January 1, 2006 We propose the use of Tomographic Digital Subtraction Angiography (TDSA) for functional imaging in small animals. TDSA combines the advantages of high temporal resolution of digital subtraction angiography (DSA) and high spatial resolution of micro-compute ... Full text Cite

Development and evaluation of an ODL course on medical image processing

Conference Proceedings of the IASTED International Conference on Web-Based Education · 2004 Link to item Cite

Optimized radiographic spectra for digital subtraction angiography in the mouse

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004 The availability of genetically altered mouse models of human disease and the increasing use of small animals in basic research have spurred extraordinary interest in new imaging methodologies - particularly magnetic resonance microscopy, microCT, and micr ... Full text Cite

Volumetric micro-CT system for in vivo microscopy

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004 Two of the major barriers to improved image quality in micro-CT are the reduced signal to noise imposed by the smaller voxels and the effects of physiologic motion. The most direct approach to increase the signal to noise ratio (SNR) is to increase the flu ... Full text Cite

Effects of breathing motion on the spatial resolution in microscopic imaging techniques of rodents

Conference 2004 2nd IEEE International Symposium on Biomedical Imaging Macro to Nano · January 1, 2004 Magnetic resonance microscopy is capable of producing high-resolution pulmonary images in live rodents by synchronizing the image acquisition across multiple breaths. The precision with which one can control motion will probably define the resolution limit ... Full text Cite