Steven Daniel Crowley

Journal article J Clin Invest · June 2014 Featured Publication An essential link between the kidney and blood pressure control has long been known. Here, we review evidence supporting the premise that an impaired capacity of the kidney to excrete sodium in response to elevated blood pressure is a major contributor to ... Full text Link to item Cite

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.

Journal article J Clin Invest · May 2014 Featured Publication In a wide array of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal interstitium. Here, we examined the actions of AT1 receptors on macrophages in progressive renal fibrosis and found that macrop ... Full text Link to item Cite

The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension.

Journal article Antioxid Redox Signal · January 1, 2014 Featured Publication SIGNIFICANCE: Innate and adaptive immunity play fundamental roles in the development of hypertension and its complications. As effectors of the cell-mediated immune response, myeloid cells and T lymphocytes protect the host organism from infection by attac ... Full text Link to item Cite

A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.

Journal article Circ Res · June 8, 2012 Featured Publication RATIONALE: Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) rec ... Full text Link to item Cite

Lymphocyte responses exacerbate angiotensin II-dependent hypertension.

Journal article Am J Physiol Regul Integr Comp Physiol · April 2010 Featured Publication Activation of the immune system by ANG II contributes to the pathogenesis of hypertension, and pharmacological suppression of lymphocyte responses can ameliorate hypertensive end-organ damage. Therefore, to examine the mechanisms through which lymphocytes ... Full text Link to item Cite

A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension.

Journal article Hypertension · January 2010 Featured Publication Activation of type 1 angiotensin (AT(1)) receptors causes hypertension, leading to progressive kidney injury. AT(1) receptors are expressed on immune cells, and previous studies have identified a role for immune cells in angiotensin II-dependent hypertensi ... Full text Link to item Cite

Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.

Journal article J Clin Invest · April 2009 Featured Publication Studies in humans and animal models indicate a key contribution of angiotensin II to the pathogenesis of glomerular diseases. To examine the role of type 1 angiotensin (AT1) receptors in glomerular inflammation associated with autoimmune disease, we genera ... Full text Link to item Cite

Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.

Journal article Am J Physiol Renal Physiol · August 2008 Featured Publication Activation of the renin-angiotensin system contributes to the progression of chronic kidney disease. Based on the known cellular effects of ANG II to promote inflammation, we posited that stimulation of lymphocyte responses by ANG II might contribute to th ... Full text Link to item Cite

In hypertension, the kidney rules.

Journal article Curr Hypertens Rep · April 2007 Featured Publication The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. Components of the RAS, including renin, angiotensin-converting enzyme (ACE), and angiotensin type 1 (AT1) receptors, are expressed throughout the body in ti ... Full text Link to item Cite

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Journal article Proc Natl Acad Sci U S A · November 21, 2006 Featured Publication Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key causative feature, but this has been difficult to test experimentally, and recent studies have challenge ... Full text Link to item Cite

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

Journal article J Clin Invest · April 2005 Featured Publication Angiotensin II, acting through type 1 angiotensin (AT(1)) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the re ... Full text Link to item Cite

A Web-based compendium of clinical questions and medical evidence to educate internal medicine residents.

Journal article Acad Med · March 2003 Featured Publication The authors designed an electronic database of clinical questions (CQs) and medical evidence and implemented it in 2001-02 at Duke University Medical Center and the Veterans Administration Medical Center in Durham, North Carolina. This Web-based data colle ... Full text Link to item Cite