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Madison Stockton Spach

James B. Duke Distinguished Professor Emeritus of Medicine
Pediatrics, Cardiology
Box 3475 Med Ctr, Durham, NC 27710
108 Research Park Bldg. 4, Durham, NC 27710

Selected Publications

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study.

Journal Article Heart Rhythm · February 2007 BACKGROUND: Aging is associated with a significant increase in atrial tachyarrhythmias, especially atrial fibrillation. A macroscopic repolarization gradient created artificially by a stimulus at one site before a premature stimulus from a second site is w ... Full text Link to item Cite

Cell size and communication: role in structural and electrical development and remodeling of the heart.

Journal Article Heart Rhythm · October 2004 With the advent of new information about alterations of cardiac gap junctions in disease conditions associated with arrhythmias, there have been major advances in the genetic and metabolic manipulation of gap junctions. In contrast, in naturally occurring ... Full text Link to item Cite

Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels.

Journal Article J Electrocardiol · 2001 Because gene therapy presents a new frontier in the treatment of arrhythmias, it has become important to know how manipulation of the cellular distribution of proteins changes electrical events within individual cells, and whether these cellular changes af ... Full text Link to item Cite