Scholars@Duke
Cynthia Ann Toth

Cynthia Ann Toth

Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
cynthia.toth@duke.edu
Duke Eye Center, DUMC 3802, Durham, NC 27710
Duke Eye Center, Hudson Bldg., 2351 Erwin Road, Durham, NC 27705

Featured Works

Optical coherence tomography in retinopathy of prematurity: looking beyond the vessels.

Journal article Clin Perinatol · June 2013 Featured Publication Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness in the United States. Optical Coherence Tomography (OCT) is a relatively new imaging technology capable of imaging ocular structures in cross section at high resolution. We present ... Full text Link to item Cite

Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration.

Journal article Retina · September 2011 Featured Publication PURPOSE: To directly assess the recovery of the retina overlying choroidal neovascularization in neovascular age-related macular degeneration and to understand the relationship between macular sensitivity and visual functional measures and retinal structur ... Full text Link to item Cite

Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity.

Journal article Retina · September 2011 Featured Publication PURPOSE: To compare vitreoretinal pathology imaged with portable handheld spectral-domain optical coherence tomography (SD-OCT) to conventional indirect ophthalmoscopic examination in neonates undergoing screening for retinopathy of prematurity. METHODS: S ... Full text Link to item Cite

Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging.

Journal article Invest Ophthalmol Vis Sci · May 16, 2011 Featured Publication PURPOSE: To demonstrate an operating microscope-mounted spectral domain optical coherence tomography (MMOCT) system for human retinal and model surgery imaging. METHODS: A prototype MMOCT system was developed to interface directly with an ophthalmic surgic ... Full text Link to item Cite

Reversible retinal edema in an infant with neonatal hemochromatosis and liver failure.

Journal article J AAPOS · February 2011 Featured Publication We present a case of bilateral severe retinal edema with subretinal fluid in an infant diagnosed with neonatal hemochromatosis and liver failure. A macular cherry-red spot in each eye mimicked the clinical appearance of many metabolic storage diseases. Bot ... Full text Link to item Cite

Treatment of non-age-related macular degeneration submacular diseases with macular translocation surgery.

Journal article Retina · 2011 Featured Publication PURPOSE: To evaluate the use of macular translocation surgery 360 in blinding submacular diseases other than age-related macular degeneration. METHODS: A retrospective, consecutive case review was performed of subjects treated with macular translocation su ... Full text Link to item Cite

Evaluation of contrast agents for enhanced visualization in optical coherence tomography.

Journal article Invest Ophthalmol Vis Sci · December 2010 Featured Publication PURPOSE: To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. METHODS: Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were test ... Full text Link to item Cite

Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery.

Journal article Opt Lett · October 15, 2010 Featured Publication We demonstrate in vivo human retinal imaging using an intraoperative microscope-mounted optical coherence tomography system (MMOCT). Our optomechanical design adapts an Oculus Binocular Indirect Ophthalmo Microscope (BIOM3), suspended from a Leica ophthalm ... Full text Open Access Link to item Cite

Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.

Journal article Invest Ophthalmol Vis Sci · October 2010 Featured Publication PURPOSE: Spectral domain-optical coherence tomography (SD-OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were co ... Full text Link to item Cite

Efficient fourier-wavelet super-resolution.

Journal article IEEE Trans Image Process · October 2010 Featured Publication Super-resolution (SR) is the process of combining multiple aliased low-quality images to produce a high-resolution high-quality image. Aside from registration and fusion of low-resolution images, a key process in SR is the restoration and denoising of the ... Full text Link to item Cite

Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation.

Journal article Opt Express · August 30, 2010 Featured Publication Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach ... Full text Open Access Link to item Cite

Optimizing hand-held spectral domain optical coherence tomography imaging for neonates, infants, and children.

Journal article Invest Ophthalmol Vis Sci · May 2010 Featured Publication PURPOSE: To describe age-related considerations and methods to improve hand-held spectral domain optical coherence tomography (HH-SD OCT) imaging of eyes of neonates, infants, and children. METHODS: Based on calculated optical parameters for neonatal and i ... Full text Link to item Cite

Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging.

Journal article Ophthalmology · December 2009 Featured Publication PURPOSE: To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Three low-birth-weight, severely premature infants. ... Full text Link to item Cite

Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome.

Journal article Arch Ophthalmol · November 2009 Featured Publication OBJECTIVE: To report a 3-generation white family clinically diagnosed variably with Wagner, Stickler, and Jansen syndromes and screened for sequence variants in the COL2A1 and CSPG2 genes. Wagner syndrome is an autosomal dominant vitreoretinopathy with a p ... Full text Link to item Cite

Spectral domain optical coherence tomography imaging of geographic atrophy margins.

Journal article Ophthalmology · September 2009 Featured Publication OBJECTIVE: To test in vivo whether spectral domain optical coherence tomography (SD-OCT) provides adequate resolution for reproducible measurement of photoreceptor (PR) layer at the margins of geographic atrophy (GA), and if it delineates the relationship ... Full text Link to item Cite

Developing SDOCT to assess donor human eyes prior to tissue sectioning for research.

Journal article Graefes Arch Clin Exp Ophthalmol · August 2009 Featured Publication BACKGROUND: To compare spectral domain optical coherence tomography (SDOCT) cross-sectional images of human central retina obtained from donor eyes with and without age-related macular degeneration (AMD) to corresponding histopathology from light micrograp ... Full text Link to item Cite

Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.

Journal article Ophthalmology · March 2009 Featured Publication PURPOSE: Detect changes in the neurosensory retina using spectral-domain optical coherence tomography (SD OCT) imaging over drusen in age-related macular degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of disease progression. D ... Full text Link to item Cite

Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device.

Journal article Am J Ophthalmol · February 2009 Featured Publication PURPOSE: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS). DESIGN: Observational case series. METHODS: A novel SD OCT system was ... Full text Link to item Cite

Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomography.

Journal article Arch Ophthalmol · January 2009 Featured Publication OBJECTIVES: To evaluate the spectrum of foveal architecture in pediatric albinism and to assess the utility of spectral-domain optical coherence tomography (OCT) in ocular imaging of children with nystagmus. METHODS: Spectral-domain OCT imaging was perform ... Full text Link to item Cite

Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery.

Journal article Retina · 2009 Featured Publication PURPOSE: To describe the intraoperative use of handheld spectral domain optical coherence tomography (SDOCT) imaging in macular surgery. DESIGN: Prospective, observational case series. METHODS: A handheld SDOCT device was used to obtain preincision optical ... Full text Link to item Cite

Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration.

Journal article Ophthalmology · November 2008 Featured Publication PURPOSE: To categorize drusen ultrastructure in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SDOCT) and correlate the tomographic and photographic drusen appearances. DESIGN: Prospective case series. PARTICIPAN ... Full text Link to item Cite

Correlation of pathologic features in spectral domain optical coherence tomography with conventional retinal studies.

Journal article Retina · February 2008 Featured Publication PURPOSE: To delineate pathologic changes in retinal cross sections obtained with spectral (Fourier) domain optical coherence tomography (SDOCT), so that the findings are maintained when collapsed into a two-dimensional fundus image for comparison with conv ... Full text Link to item Cite

Quantifying vertical angle kappa after macular translocation surgery: a new use for the synoptophore.

Journal article Strabismus · 2008 Featured Publication PURPOSE: To report the measurement of vertical angle kappa and its application in patients after full macular translocation (MT360) and extraocular muscle surgery (to correct the resultant large angle torsion), in a prospective study. METHODS: A custom sli ... Full text Link to item Cite

Optical coherence tomography reader agreement in neovascular age-related macular degeneration.

Journal article Am J Ophthalmol · July 2007 Featured Publication PURPOSE: To determine the interreader and intrareader agreement at the Optical Coherence Tomography (OCT) Reading Center at Duke for images produced for an interventional neovascular age-related macular degeneration (AMD) clinical trial. DESIGN: Retrospect ... Full text Link to item Cite

Fixation switch and diplopia after full macular translocation surgery.

Journal article J AAPOS · April 2007 Featured Publication PURPOSE: We sought to identify and evaluate treatment of patients who switched fixation to the poorer-seeing eye and complained of persistent diplopia 6 to 12 months after full macular translocation surgery (MT360) and extraocular muscle surgery. METHODS: ... Full text Link to item Cite

Complement factor H increases risk for atrophic age-related macular degeneration.

Journal article Ophthalmology · September 2006 Featured Publication OBJECTIVE: To determine if the complement factor H gene (CFH) determines risk for development of geographic atrophy (GA). DESIGN: Retrospective case-control study. PARTICIPANTS AND CONTROLS: The independent case-control data set contained 647 age-related m ... Full text Link to item Cite

Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16.

Journal article Am J Ophthalmol · January 2006 Featured Publication PURPOSE: To compare the fundus photographic and fluorescein angiographic features with the histologic findings in eyes from patients enrolled in the Submacular Surgery Trials (SST). DESIGN: Clinical trials with clinicopathologic correlation. METHODS: Eyes ... Full text Link to item Cite

Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management.

Journal article Ophthalmology · January 2006 Featured Publication PURPOSE: To report a new extraocular muscle surgery procedure for large-angle extorsion, and clinical management of subjective tilt and diplopia after full macular translocation (MT360). DESIGN: Consecutive retrospective case series. PARTICIPANTS: Seven pa ... Full text Link to item Cite

Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

Journal article Proc Natl Acad Sci U S A · August 16, 2005 Featured Publication Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the Western world. We describe here a murine model that combines three known ... Full text Link to item Cite

Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.

Journal article Arch Ophthalmol · July 2005 Featured Publication OBJECTIVE: To assess the prevalence of recurrence of macular geographic atrophy (GA) of the retinal pigment epithelium (RPE) after macular translocation with 360 degrees retinectomy (MT360) in one institution. METHODS: A retrospective review of all cases o ... Full text Link to item Cite

Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7.

Journal article Arch Ophthalmol · July 2005 Featured Publication OBJECTIVES: To identify the histologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions from patients enrolled in the Submacular Surgery Trials and to compare them with clinical data. METHODS: Surgically excised su ... Full text Link to item Cite

Vision-related quality of life in patients with bilateral severe age-related macular degeneration.

Journal article Ophthalmology · January 2005 Featured Publication PURPOSE: To determine the quality of life (QOL) of patients with bilateral severe age-related macular degeneration (AMD) before macular translocation with 360 degrees peripheral retinectomy. DESIGN: Prospective, consecutive, noncomparative case series. MET ... Full text Link to item Cite

Impact of fluorescein angiographic characteristics of macular lesions on outcomes after macular translocation 360 degree surgery in eyes with age-related macular degeneration.

Journal article Retina · 2005 Featured Publication PURPOSE: To evaluate the relationship between preoperative lesion size and composition and visual outcomes at 1 year after macular translocation surgery with 360 degree peripheral retinectomy (MT360) for neovascular age-related macular degeneration (AMD). ... Full text Link to item Cite

Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration.

Journal article Ophthalmology · January 2005 Featured Publication PURPOSE: To determine patients' quality of life (QOL) after macular translocation with 360 degrees peripheral retinectomy (MT360) for age-related macular degeneration. DESIGN: Prospective, interventional, consecutive, noncomparative case series. METHODS: A ... Full text Link to item Cite

Surgical removal vs observation for subfoveal choroidal neovascularization, either associated with the ocular histoplasmosis syndrome or idiopathic: I. Ophthalmic findings from a randomized clinical trial: Submacular Surgery Trials (SST) Group H Trial: SST Report No. 9.

Journal article Arch Ophthalmol · November 2004 Featured Publication OBJECTIVE: To present visual acuity findings and related outcomes from eyes of patients enrolled in a randomized trial conducted by the Submacular Surgery Trials (SST) Research Group (SST Group H Trial) to compare surgical removal vs observation of subfove ... Full text Link to item Cite

Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration.

Journal article Ophthalmology · September 2004 Featured Publication OBJECTIVE: To measure the change in vision and visual outcomes at 12 months after macular translocation with 360 degrees retinectomy (MT360) and silicone oil tamponade in patients with bilateral vision loss resulting from subfoveal choroidal neovascular me ... Full text Link to item Cite

Radial optic neurotomy in the porcine eye without retinal vein occlusion.

Journal article Arch Ophthalmol · August 2004 Featured Publication OBJECTIVE: To demonstrate the histopathologic changes in the porcine eye without retinal vein occlusion after radial optic neurotomy (RON). METHODS: A RON was performed in 14 normal eyes of 12 Yorkshire Cross pigs. One radial stab incision at the edge of t ... Full text Link to item Cite

Improvement in near visual function after macular translocation surgery with 360-degree peripheral retinectomy.

Journal article Graefes Arch Clin Exp Ophthalmol · July 2004 Featured Publication BACKGROUND: Information is limited on how specific near-vision skills are impacted by therapies such as macular translocation surgery with 360-degree retinectomy (MT360) for age-related macular degeneration (AMD). METHODS: Standardized tests of near vision ... Full text Link to item Cite

Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size.

Journal article J Biomed Opt · 2004 Featured Publication We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in e ... Full text Link to item Cite

Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization.

Journal article Am J Ophthalmol · November 2003 Featured Publication PURPOSE: To determine the visual outcomes of eyes that underwent macular translocation surgery with 360 degrees peripheral retinectomy and silicone oil tamponade (MTS360) following ocular photodynamic therapy (OPT) with verteporfin for subfoveal choroidal ... Full text Link to item Cite

Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study.

Journal article Am J Ophthalmol · October 2003 Featured Publication PURPOSE: To report the results of a prospective clinical series to evaluate the management of both torsion and diplopia in a large group of patients after full macular translocation (FMT) and extraocular muscle surgery. DESIGN: Prospective interventional c ... Full text Link to item Cite

Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rod.

Journal article J AAPOS · April 2003 Featured Publication PURPOSE: To compare two methods of measuring ocular torsion (the subjective Maddox rod [MR] test versus the objective disc-fovea angle [DFA] test) after macular translocation surgery. METHODS: Ocular torsion was measured on consecutive patients after macul ... Full text Link to item Cite

RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis.

Journal article Curr Eye Res · December 2002 Featured Publication PURPOSE: To evaluate a new concept in pharmacological vitreolysis by studying the efficacy of intravitreal RGD peptide-assisted vitrectomy in facilitating the separation of the posterior cortical vitreous from the retinal surface in an animal model. METHOD ... Full text Link to item Cite

Development and characterization of a vitreous mimicking material for radiation force imaging.

Journal article IEEE Trans Ultrason Ferroelectr Freq Control · November 2002 Featured Publication In many medical ultrasound applications tissue-mimicking phantoms are of fundamental importance for the performance of controlled experiments. Traditionally, such phantoms have been constructed using gelatin and agar gels. Although the use of these materia ... Full text Link to item Cite

Visual outcomes following macular translocation with 360-degree peripheral retinectomy.

Journal article Arch Ophthalmol · October 2002 Featured Publication OBJECTIVE: To evaluate visual outcomes following macular translocation with 360 degrees peripheral retinectomy in patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. METHODS: In a prospective study, 15 consec ... Full text Link to item Cite

Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration.

Journal article Arch Ophthalmol · June 2002 Featured Publication OBJECTIVE: To determine the prevalence and visual significance of cystoid macular edema (CME) in eyes with subfoveal neovascular age-related macular degeneration using optical coherence tomography (OCT). MATERIALS AND METHODS: The medical records of 61 con ... Full text Link to item Cite

Strabismus surgery for large-angle cyclotorsion after macular translocation surgery.

Journal article J AAPOS · June 2002 Featured Publication PURPOSE: We report the results of a new strabismus surgical procedure to address the large-angle cyclotorsion induced by macular translocation surgery for severe age-related macular degeneration. METHODS: The strabismus surgery described is a modification ... Full text Link to item Cite

Thresholds for retinal injury from multiple near-infrared ultrashort laser pulses.

Journal article Health Phys · June 2002 Featured Publication Multiple-pulse lasers are routinely used in the laboratory for research, manufacturing, medical procedures, and in military applications. In order to provide a safe work environment for personnel using these lasers, safety standards have been established a ... Full text Link to item Cite

LASIK and vitreous pathology after LASIK.

Other Ophthalmology · April 2002 Featured Publication Full text Link to item Cite

Age-related changes in vitreous mobility as measured by video B scan ultrasound.

Journal article Exp Eye Res · February 2002 Featured Publication Many vitreoretinal disorders increase in incidence with age. The vitreous is known to liquefy and separate from the retina in aging patients. Liquefaction and partial vitreous separation alter the biomechanics of the vitreous and change the tractional forc ... Full text Link to item Cite

A comparative study of retinal effects from continuous wave and femtosecond mode-locked lasers.

Journal article Lasers Surg Med · 2002 Featured Publication BACKGROUND AND OBJECTIVES: In order to provide a direct comparison of the effects of mode-locked systems to those with continuous-wave (CW) or nonpulsed output, we have performed an experiment with lasers possessing otherwise identical output characteristi ... Full text Link to item Cite

Macular translocation with radial scleral ouffolding: experimental studies and initial human results.

Journal article Graefes Arch Clin Exp Ophthalmol · November 2001 Featured Publication PURPOSE: Different techniques have been proposed for translocating the macula in patients with subfoveal neovascularization secondary to age-related macular degeneration. A new approach utilizing radial outfolding of the sclera was investigated. MATERIALS ... Full text Link to item Cite

Induced corneal astigmatism after macular translocation surgery with scleral infolding.

Journal article Ophthalmology · July 2001 Featured Publication OBJECTIVE: To document the corneal astigmatism that occurs with macular translocation after scleral infolding surgery. DESIGN: Retrospective case series of a nonrandomized clinical trial. PARTICIPANTS: Eight consecutive age-related macular degeneration pat ... Full text Link to item Cite

Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature.

Journal article Graefes Arch Clin Exp Ophthalmol · June 2001 Featured Publication BACKGROUND: The development of tears of the retinal pigment epithelium (RPE) has classically been described with or without choroidal neovascularization (CNV) or after laser treatment. Tangential shear forces within the RPE or CNV are usually considered to ... Full text Link to item Cite

Macular translocation: unifying concepts, terminology, and classification.

Journal article Am J Ophthalmol · February 2001 Featured Publication PURPOSE: To describe some unifying concepts, terminology, and classification of macular translocation so as to facilitate communication within the scientific community. METHODS: A panel of ophthalmologists with expertise in macular translocation reviewed a ... Full text Link to item Cite

Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration.

Journal article Am J Ophthalmol · February 2001 Featured Publication PURPOSE: To evaluate a new procedure for displacement of large, thick submacular hemorrhage in patients with age-related macular degeneration. METHODS: Retrospective review of 11 eyes of 11 patients with age-related macular degeneration and thick submacula ... Full text Link to item Cite

In-vivo response to free electron laser incision of the rabbit cornea.

Journal article Lasers Surg Med · 2001 Featured Publication BACKGROUND AND OBJECTIVE: We analyzed the in vivo ocular response to corneal incisions made by Medical Free Electron Laser (MFEL) as a function of scan rate and incision depth. Additionally, we compared biomicroscopy, optical coherence tomography (OCT), an ... Full text Link to item Cite

Successful macular translocation with temporary scleral infolding using absorbable sture.

Journal article Retina · 2001 Featured Publication PURPOSE: To describe successful macular translocation with temporary scleral infolding in a series of patients with small subfoveal choroidal neovascularization due to age-related macular degeneration or ocular histoplasmosis syndrome. METHODS: Ten eyes of ... Full text Link to item Cite

Macular translocation with 360-degree peripheral retinectomy impact of technique and surgical experience on visual outcomes.

Journal article Retina · 2001 Featured Publication PURPOSE: To evaluate the impact of technique and surgical experience on complications and outcomes of macular translocation surgery with 360-degree peripheral retinectomy (MTS360). METHODS: Twenty-six consecutive patients underwent MTS360 in a prospective ... Full text Link to item Cite

Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses.

Journal article J Biomed Opt · July 2000 Featured Publication Single 130 fs laser pulses in the near-IR (800 nm) were used to create ophthalmoscopically viewed minimum visible lesions (MVLs) within the macular and paramacular regions in rhesus monkey eyes. MVL thresholds at 1 and 24 h are reported as the 50% probabil ... Full text Link to item Cite

Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery.

Journal article J AAPOS · April 2000 Featured Publication PURPOSE: The purpose of this study was to evaluate the effects of oblique muscle surgery on the large-angle incyclotorsion resulting from macular translocation surgery for severe age-related macular degeneration. METHODS: Patients undergoing macular transl ... Full text Link to item Cite

Features of macular hole closure in the early postoperative period using optical coherence tomography.

Journal article Retina · 2000 Featured Publication PURPOSE: Studying the retina in the early postoperative period after macular hole surgery is difficult because of the limitation of imaging of the fundus through a gas tamponade. Silicone oil was shown recently to be an effective alternative to gas for mac ... Link to item Cite

Electron immunocytochemical analysis of posterior hyaloid associated with diabetic macular edema.

Journal article Retina · 2000 Featured Publication BACKGROUND: Tangential traction in the macula from a thickened posterior hyaloid of the vitreous has been implicated as a cause of diffuse diabetic macular edema. Vitrectomy with peeling of the posterior hyaloid has been shown to reduce retinovascular leak ... Full text Link to item Cite

Diagnosis of vitreoretinal adhesions in macular disease with optical coherence tomography.

Journal article Retina · 2000 Featured Publication PURPOSE: To compare the relative incidence of vitreoretinal adhesions associated with partial vitreous separation within the macula diagnosed with optical coherence tomography (OCT) with that of those diagnosed with biomicroscopy. METHODS: The authors obta ... Link to item Cite

Thresholds for visible lesions in the primate eye produced by ultrashort near-infrared laser pulses.

Journal article Invest Ophthalmol Vis Sci · September 1999 Featured Publication PURPOSE: To evaluate the effects of near-infrared (near-IR) ultrashort laser pulses on the retinas of rhesus monkey eyes and to perform threshold measurements for minimum visible lesions (MVLs) at pulse widths ranging from nanoseconds to femtoseconds. METH ... Link to item Cite

Ultrashort laser pulse bioeffects and safety.

Journal article J Laser Appl · February 1999 Featured Publication Recent studies of retinal damage due to ultrashort laser pulses have shown that less energy is required for retinal damage for pulses shorter than 1 ns than that for longer pulses. It has also been shown that more energy is required for near-infrared (NIR) ... Full text Link to item Cite

Matrix metalloproteinases and their inhibitors in human vitreous.

Journal article Invest Ophthalmol Vis Sci · June 1998 Featured Publication PURPOSE: To conduct zymographic analysis to study the matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in vitreous samples of patients undergoing pars plana vitrectomy as part of the treatment of vitreoretinal disease. ME ... Link to item Cite

A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy.

Journal article Arch Ophthalmol · November 1997 Featured Publication OBJECTIVE: To compare the cross-sectional images of primate retinal morphology obtained by optical coherence tomography (OCT) with light microscopy to determine the retinal components represented in OCT images. METHODS: Laser pulses were delivered to the r ... Full text Link to item Cite

Pathology of macular lesions from subnanosecond pulses of visible laser energy.

Journal article Invest Ophthalmol Vis Sci · October 1997 Featured Publication PURPOSE: To demonstrate how current theories regarding ultrashort laser pulse effects may apply to ocular tissue, a prospective clinicopathologic study of macular lesions from ultrashort laser pulses compared the pathologic effects with the clinical and fl ... Link to item Cite

Recombinant hirudin prevents postoperative fibrin formation after experimental cataract surgery.

Journal article Ophthalmology · March 1997 Featured Publication PURPOSE: The authors studied the effect of a direct acting antithrombin agent, desulfatohirudin variant 1 (Revasc, Ciba-Geigy, Ltd., Basel, Switzerland), on postoperative fibrin formation after cataract surgery in rabbits. METHODS: Phacoemulsification was ... Full text Link to item Cite

Intraocular laser surgical probe for membrane disruption by laser-induced breakdown.

Journal article Appl Opt · March 1, 1997 Featured Publication A fiber probe has been designed as a surgical aid to cut intraocular membranes with laser-induced breakdown as the mechanism. The design of the intraocular laser surgical probe is discussed. A preliminary retinal damage distance has been calculated with br ... Full text Link to item Cite

Argon laser retinal lesions evaluated in vivo by optical coherence tomography.

Journal article Am J Ophthalmol · February 1997 Featured Publication PURPOSE: To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential optical coherence tomography with histopathologic sectioning. METHODS: Argon laser lesions were created in the retinas of M ... Full text Link to item Cite

Intraocular injection of recombinant hirudin to prevent experimental postoperative fibrin.

Journal article Retina · 1997 Featured Publication PURPOSE: To test the efficacy of a single intraocular injection of various doses of recombinant desulphatohirudin variant 1 (Revasc) in a rabbit model after lensectomy-vitrectomy surgery. METHODS: Standard fragmatome lensectomies and core vitrectomies were ... Full text Link to item Cite

Retinal damage and laser-induced breakdown produced by ultrashort-pulse lasers.

Journal article Graefes Arch Clin Exp Ophthalmol · August 1996 Featured Publication BACKGROUND: In vivo retinal injury studies using ultra-short-pulse lasers at visible wavelengths for both rabbit and primate eyes have shown that the degree of injury to the retina is not proportional to the pulse energy, especially at suprathreshold level ... Full text Link to item Cite

Recombinant hirudin for prevention of experimental postoperative intraocular fibrin.

Journal article Am J Ophthalmol · May 1996 Featured Publication PURPOSE: To determine the efficacy of a specific antithrombin agent (recombinant desulphatohirudin variant 1 [Revasc, Ciba-Geigy, Ltd., Basel, Switzerland]) administered in the infusion fluid to prevent early postoperative fibrin formation in a rabbit lens ... Full text Link to item Cite

Tissue plasminogen activator for preserving inferior peripheral iridectomy patency in eyes with silicone oil.

Journal article Ophthalmology · February 1996 Featured Publication PURPOSE: An inferior peripheral iridectomy (IPI) was used to prevent forward migration of silicone oil in vitrectomized eyes; however, in approximately one third of eyes, the IPI closed spontaneously. Occlusion of the IPI by fibrin is believed to be an ear ... Full text Link to item Cite

Retinal effects of ultrashort laser pulses in the rabbit eye.

Journal article Invest Ophthalmol Vis Sci · August 1995 Featured Publication PURPOSE: To evaluate the effects of ultrashort laser pulses from femtoseconds to nanoseconds on the retinas of live rabbit eyes and to determine the energy requirements for visible lesion development. METHODS: The retinal effects of laser exposures were ex ... Link to item Cite

Diabetic retinopathy in a cat.

Other Exp Eye Res · May 1995 Featured Publication Full text Link to item Cite

Visible retinal lesions from ultrashort laser pulses in the primate eye.

Journal article Invest Ophthalmol Vis Sci · April 1995 Featured Publication PURPOSE: To evaluate the effects of ultrashort laser pulses of visible wavelengths on the retinas of rhesus monkey eyes and to perform threshold measurements for minimum visible lesions (MVLs) at pulsewidths from nanoseconds to femtoseconds. METHODS: Singl ... Link to item Cite

Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration.

Journal article Ophthalmology · February 1995 Featured Publication BACKGROUND: A correlation of the clinical and histopathologic features of age-related macular degeneration (AMD), complicated by choroidal neovascular membrane (CNVM) with spontaneous tears of retinal pigment epithelial (RPE) detachment, has not been repor ... Full text Link to item Cite

Nonlinear refraction in vitreous humor.

Journal article Opt Lett · November 1, 1993 Featured Publication We extend the application of the z-scan technique to determine the nonlinear refractive index (n(2)) for human and rabbit vitreous humor, water, and physiological saline. In these measurements there were nonlinear contributions to the measured signal from ... Full text Link to item Cite

A glass micropipette holder for ophthalmic surgical procedures.

Journal article Am J Ophthalmol · October 15, 1993 Featured Publication Full text Link to item Cite

A new wide-field temporary keratoprosthesis.

Other Retina · 1993 Featured Publication Link to item Cite

Stainless steel micropipette for subretinal surgery.

Other Am J Ophthalmol · June 15, 1992 Featured Publication Full text Link to item Cite

An experimental model of ectropion uveae and iris neovascularization in the cat.

Journal article Invest Ophthalmol Vis Sci · April 1992 Featured Publication Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris ... Link to item Cite

Ultramicrosurgical removal of subretinal hemorrhage in cats.

Journal article Am J Ophthalmol · February 15, 1992 Featured Publication Subretinal hemorrhages are associated with progressive degeneration of the outer retina and a corresponding poor visual prognosis. Mixed results have been reported in previous attempts to remove such subretinal hemorrhages. We developed an ultramicrosurgic ... Full text Link to item Cite

Treatment of retinopathy of prematurity with argon laser photocoagulation.

Journal article Arch Ophthalmol · January 1992 Featured Publication Fifteen eyes of nine infants were treated for retinopathy of prematurity by confluent photocoagulation of the avascular retina using an argon laser indirect ophthalmoscope. All treated eyes presented at or beyond threshold of stage 3 retinopathy of prematu ... Full text Link to item Cite

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye.

Journal article Graefes Arch Clin Exp Ophthalmol · 1992 Featured Publication The feasibility of gamma (gamma)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit gamma-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that int ... Full text Link to item Cite

Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat.

Journal article Arch Ophthalmol · December 1991 Featured Publication To explore the feasibility of using human recombinant tissue-type plasminogen activator in the management of subretinal hemorrhage, we examined the toxic effects of a commercial preparation of human recombinant tissue-type plasminogen activator in the subr ... Full text Link to item Cite

Fibrin directs early retinal damage after experimental subretinal hemorrhage.

Journal article Arch Ophthalmol · May 1991 Featured Publication Subretinal blood within the macula may cause visual loss in a number of macular diseases. The clinical and histopathologic effects of experimental subretinal hemorrhage were evaluated in the cat. Subretinal hemorrhages were produced by creating a focal neu ... Full text Link to item Cite