Cynthia Ann Toth

Journal article JAMA Ophthalmol · July 1, 2026 IMPORTANCE: Limiting the stress of retinopathy of prematurity (ROP) assessments may be beneficial for preterm infants. OBJECTIVE: To compare stress in preterm infants from noncontact optical coherence tomography (OCT) vs contact fundus photography during R ... Full text Link to item Cite

Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.

Journal article JAMA Ophthalmol · July 1, 2026 IMPORTANCE: If noninvasive optical coherence tomography (OCT) retinal imaging could predict 2-year neurodevelopment of very preterm (VPT; <32 weeks' gestational age) infants in neonatal intensive care, it might help to guide management. OBJECTIVE: To evalu ... Full text Link to item Cite

Utility of handheld optical coherence tomography imaging in the surgical management of preterm infants with advanced retinopathy of prematurity.

Journal article Graefes Arch Clin Exp Ophthalmol · April 9, 2026 PURPOSE: The advent of handheld optical coherence tomography (OCT) as a research instrument has significantly advanced our understanding of retinopathy of prematurity (ROP). We aim to determine if OCT imaging can aid in surgical decision-making for preterm ... Full text Link to item Cite

Optical Coherence Tomography with Fluorescein Optical Clearing for Transscleral Image Guidance

Journal article International Journal of Translational Medicine · March 1, 2026 Background: Scattering of the sclera limits optical coherence tomography (OCT) imaging of deeper targets including lesions, malignancies, and other surgical targets. While existing applications of fluorescein dye are currently focused on fluorescence prope ... Full text Cite

Comparison of Retinal and Choroidal OCT Measures and Features at Term Equivalent Age in Preterm and Term Infants.

Journal article Invest Ophthalmol Vis Sci · October 1, 2025 PURPOSE: To evaluate macular optical coherence tomography (OCT) features at term-equivalent age in preterm and term infants, and to test the hypothesis that both preterm birth and retinopathy of prematurity (ROP) are associated with differences in OCT meas ... Full text Link to item Cite

Handheld 400kHz optical coherence tomography angiography visualizes microvascular details in infants with advanced retinopathy of prematurity.

Journal article Am J Ophthalmol Case Rep · September 2025 Clinical evaluation of the disease activity of retinopathy of prematurity (ROP) is routinely performed via indirect ophthalmoscopy and/or widefield fundus photography. Herein we report an infant with advanced ROP imaged with an investigational handheld 400 ... Full text Link to item Cite

Optical Coherence Tomography with Fluorescein Optical Clearing for Transscleral Image Guidance.

Journal article bioRxiv · July 5, 2025 Optical coherence tomography (OCT) is a non-invasive, three-dimensional imaging modality demonstrated to yield a wealth of high-resolution structural and functional information in a variety of biomedical imaging applications. However, there is a significan ... Full text Link to item Cite

Clinical Characteristics and Treatment Outcomes in Unilateral Coats Disease: A Global Collaborative Study.

Journal article Ophthalmol Retina · June 2025 PURPOSE: To evaluate the clinical outcomes and prognostic factors in unilateral Coats disease in the era of anti-VEGF therapy. DESIGN: Global, multicenter, retrospective case series. SUBJECTS: Six hundred fifty-six eyes of 656 subjects with Coats disease w ... Full text Link to item Cite

Rare pediatric retinal diseases: A review.

Journal article Indian J Ophthalmol · May 1, 2025 Rare pediatric retinal disorders present significant challenges in diagnosis and management due to their limited prevalence and diverse clinical manifestations. This paper provides a comprehensive review of select rare retinal disorders affecting the pedia ... Full text Link to item Cite

New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.

Journal article Transl Vis Sci Technol · January 2, 2025 The introduction of optical coherence tomography (OCT) in the 1990s revolutionized diagnostic ophthalmic imaging. Initially, OCT's role was primarily in the adult ambulatory ophthalmic clinics. Subsequent advances in handheld form factors, integration into ... Full text Link to item Cite

Pigment epithelium detachment with thickened choroid in a preterm infant at term-equivalent age: a case report.

Journal article Front Med (Lausanne) · 2025 Pigment epithelial detachment (PED) is well-documented in adult retinal diseases but is rarely reported in neonates. This case describes a preterm infant, born at 31 weeks, who developed PED with thickened choroid at term-equivalent age, detected using han ... Full text Link to item Cite

Optical clearing with tartrazine enables deep transscleral imaging with optical coherence tomography.

Journal article J Biomed Opt · December 2024 SIGNIFICANCE: Imaging deep structures with optical coherence tomography (OCT) is difficult in highly scattering biological tissue, such as the sclera. There is a need to visualize the suprachoroidal space and choroid through the sclera to study suprachoroi ... Full text Link to item Cite

Erratum: Publisher's Note: Optical clearing with tartrazine enables deep transscleral imaging with optical coherence tomography.

Journal article J Biomed Opt · December 2024 [This corrects the article DOI: 10.1117/1.JBO.29.12.120501.]. ... Full text Link to item Cite

P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity.

Journal article Ophthalmology · November 2024 PURPOSE: The International Classification of Retinopathy of Prematurity, Third Edition (ICROP3), acknowledged that plus-like retinopathy of prematurity (ROP) vascular changes occurs along a spectrum. Historically, clinician-experts demonstrate variable agr ... Full text Link to item Cite

Optical Clearing with Tartrazine Enables Deep Transscleral Imaging with Optical Coherence Tomography.

Journal article bioRxiv · October 29, 2024 Suprachoroidal injections are a relatively new method of drug delivery to treat retinal disease. At present, it is difficult to visualize the distribution of injection-delivered product beneath the sclera into the suprachoroidal space. Imaging the supracho ... Full text Link to item Cite

Joseph A. Izatt (1962–2024)

Journal article Nature Photonics · August 2024 Full text Cite

Artificial Intelligence, Digital Imaging, and Robotics Technologies for Surgical Vitreoretinal Diseases.

Journal article Ophthalmol Retina · July 2024 OBJECTIVE: To review recent technological advancement in imaging, surgical visualization, robotics technology, and the use of artificial intelligence in surgical vitreoretinal (VR) diseases. BACKGROUND: Technological advancements in imaging enhance both pr ... Full text Link to item Cite

Optical clearing with tartrazine enables deep transscleral imaging with optical coherence tomography.

Journal article J Biomed Opt · June 2024 SIGNIFICANCE: Imaging deep structures with optical coherence tomography (OCT) is difficult in highly scattering biological tissue, such as the sclera. There is a need to visualize the suprachoroidal space and choroid through the sclera to study suprachoroi ... Full text Link to item Cite

Early Single-Examination Optical Coherence Tomography Biomarkers for Treatment-Requiring Retinopathy of Prematurity.

Journal article Invest Ophthalmol Vis Sci · April 1, 2024 PURPOSE: Optical coherence tomography (OCT) is an emerging adjunct imaging modality to evaluate retinopathy of prematurity (ROP). From an 11-year research database, we identify early OCT biomarkers that predict treatment-requiring ROP (TR-ROP). METHODS: Fo ... Full text Link to item Cite

A pilot optical coherence tomography angiography classification of retinal neovascularization in retinopathy of prematurity.

Journal article Sci Rep · January 4, 2024 Extraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural OCT, ... Full text Link to item Cite

Longitudinal Choroidal Development in Preterm Infants.

Journal article Ophthalmol Sci · 2024 PURPOSE: To characterize changes in subfoveal choroidal thickness in preterm infants from 30 to 60 weeks' postmenstrual age (PMA). DESIGN: The prospective, observational Study of Eye Imaging in Preterm infantS (BabySTEPS) enrolled infants eligible for reti ... Full text Link to item Cite

Intraoperative OCT-Guided Volumetric Measurements of Subretinal Therapy Delivery in Humans.

Journal article J Vitreoretin Dis · 2024 Purpose: To evaluate a recently developed technique using intraoperative optical coherence tomography (OCT) to measure subretinal tissue plasminogen activator (tPA) volumes in patients with submacular hemorrhage secondary to exudative age-related macular d ... Full text Link to item Cite

Computer versus human-expert ranking of posterior pole vascular tortuosity and dilation using retinal vessel maps generated from bedside optical coherence tomography: a proof-of-concept study.

Journal article J AAPOS · December 2023 Semiautomated computer software (ie, ROPtool) can trace and analyze optical coherence tomography (OCT)-generated retinal vessel maps for plus/pre-plus disease with high reliability and accuracy. This proof-of-concept study found that ROPtool can reliably r ... Full text Link to item Cite

Biphasic change in retinal nerve fibre layer thickness from 30 to 60 weeks postmenstrual age in preterm infants.

Journal article Br J Ophthalmol · November 2023 BACKGROUND/AIMS: The optic nerve development during the critical postnatal weeks of preterm infants is unclear. We aimed to investigate the change of retinal nerve fibre layer (RNFL) in preterm infants. METHODS: We used an investigational handheld optical ... Full text Link to item Cite

A Deep-Learning Algorithm to Predict Short-Term Progression to Geographic Atrophy on Spectral-Domain Optical Coherence Tomography.

Journal article JAMA Ophthalmol · November 1, 2023 IMPORTANCE: The identification of patients at risk of progressing from intermediate age-related macular degeneration (iAMD) to geographic atrophy (GA) is essential for clinical trials aimed at preventing disease progression. DeepGAze is a fully automated a ... Full text Link to item Cite

Optical Coherence Tomography and Eye Care.

Journal article N Engl J Med · October 19, 2023 Full text Link to item Cite

Erratum: Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy: publisher's note.

Journal article Biomed Opt Express · October 1, 2023 [This corrects the article on p. 3308 in vol. 14, PMID: 37497493.]. ... Full text Link to item Cite

MACULAR NEUROVASCULAR ABNORMALITIES IN A CHILD WITH INCONTINENTIA PIGMENTI ON HANDHELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Journal article Retin Cases Brief Rep · September 1, 2023 PURPOSE: To report macular neurovascular abnormalities in a child with incontinentia pigmenti using handheld optical coherence tomography (OCT) and OCT angiography (OCT-A). METHODS: An eye of a child with incontinentia pigmenti enrolled in BabySTEPS was im ... Full text Link to item Cite

Ocular Pigmentation Impact on Retinal Versus Choroidal Optical Coherence Tomography Imaging in Preterm Infants.

Journal article Transl Vis Sci Technol · July 3, 2023 PURPOSE: To evaluate the association of fundus pigmentation with the visibility of retinal versus choroidal layers on optical coherence tomography (OCT) in preterm infants. METHODS: For infants enrolled in BabySTEPS, ophthalmologists recorded fundus pigmen ... Full text Link to item Cite

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Journal article Retin Cases Brief Rep · July 1, 2023 BACKGROUND/PURPOSE: Visualization of peripheral retinal structures with optical coherence tomography (OCT) can be challenging but can offer valuable clinical information. We describe a method for intraoperative OCT of the peripheral retina. METHODS: An inv ... Full text Link to item Cite

Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.

Journal article Biomed Opt Express · July 1, 2023 4D-microscope-integrated optical coherence tomography (4D-MIOCT) is an emergent multimodal imaging technology in which live volumetric OCT (4D-OCT) is implemented in tandem with standard stereo color microscopy. 4D-OCT provides ophthalmic surgeons with man ... Full text Link to item Cite

Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.

Journal article Biomed Opt Express · July 1, 2023 Ophthalmic microsurgery is traditionally performed using stereomicroscopes and requires visualization and manipulation of sub-millimeter tissue structures with limited contrast. Optical coherence tomography (OCT) is a non-invasive imaging modality that can ... Full text Link to item Cite

Experts discuss the benefits of this new imaging modality, as well as pitfalls to avoid

Journal article Retina Today · April 1, 2023 Cite

Low-Dose Intravitreal Methotrexate for Proliferative Vitreoretinopathy.

Journal article Ophthalmic Surg Lasers Imaging Retina · March 2023 BACKGROUND AND OBJECTIVE: Proliferative vitreoretinopathy (PVR) has been mitigated by intravitreal methotrexate (MTX) 400 μg/0.1 mL in several studies. Here, we evaluate the results from a lower dose of MTX, 200 μg/0.05 mL. MATERIALS AND METHODS: We identi ... Full text Link to item Cite

Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

Journal article Br J Ophthalmol · February 2023 BACKGROUND/AIMS: Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography.

Journal article Biomed Opt Express · January 1, 2023 Intraoperative optical coherence tomography (OCT) systems provide high-resolution, real-time visualization and/or guidance of microsurgical procedures. While the use of intraoperative OCT in ophthalmology has significantly improved qualitative visualizatio ... Full text Link to item Cite

VOLUME PROBLEMS

Journal article Retina Today · January 1, 2023 Cite

Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.

Journal article Front Pediatr · 2023 The increasing survival of preterm infants has led to the importance of improving long-term outcomes associated with preterm birth. Antenatal and perinatal insults not only impact mortality, but also long-term disability. While in the intensive care nurser ... Full text Link to item Cite

Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.

Journal article Ophthalmol Retina · September 2022 PURPOSE: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age ... Full text Link to item Cite

Semi-automated vessel analysis of en face posterior pole vessel maps generated from optical coherence tomography for diagnosis of plus or pre-plus disease.

Journal article J AAPOS · August 2022 En face retinal vessel maps generated from bedside optical coherence tomography (OCT) can show posterior pole vascular tortuosity and dilation (ie, plus/pre-plus disease). In this proof-of-concept study, we found that ROPtool could trace OCT-generated reti ... Full text Link to item Cite

Artificial Intelligence for Retinopathy of Prematurity: Validation of a Vascular Severity Scale against International Expert Diagnosis.

Journal article Ophthalmology · July 2022 PURPOSE: To validate a vascular severity score as an appropriate output for artificial intelligence (AI) Software as a Medical Device (SaMD) for retinopathy of prematurity (ROP) through comparison with ordinal disease severity labels for stage and plus dis ... Full text Link to item Cite

Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data.

Journal article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Early diagnosis of plus disease is critical in the management of retinopathy of prematurity (ROP). However, there is substantial interexpert disagreement in the diagnosis of plus disease based on vascular changes alone. Information derived from ... Full text Link to item Cite

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.

Journal article JAMA Ophthalmol · July 1, 2022 IMPORTANCE: Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. OBJECTIVE: To evaluate the association between preterm in ... Full text Link to item Cite

Retinopathy of prematurity classification updates: possible implications for treatment.

Journal article J AAPOS · June 2022 Full text Link to item Cite

Machine learning OCT predictors of progression from intermediate age-related macular degeneration to geographic atrophy and vision loss.

Journal article Ophthalmol Sci · June 2022 OBJECTIVE: To describe optical coherence tomography (SD-OCT) features, age, gender, and systemic variables that may be used in machine/deep learning studies to identify high-risk patient subpopulations with high risk of progression to geographic atrophy (G ... Full text Link to item Cite

INTERMEDIATE UVEITIS WITH RETINAL DETACHMENT IN A PATIENT WITH POMPE DISEASE.

Journal article Retin Cases Brief Rep · May 1, 2022 PURPOSE: To describe the ocular findings in a patient with glycogen storage disease II (Pompe disease). METHODS: Case report. RESULTS: A 14-year-old boy with Pompe disease was referred for evaluation of a retinal detachment in the left eye. Indirect ophtha ... Full text Link to item Cite

OCULAR MANIFESTATIONS OF PORETTI-BOLTSHAUSER SYNDROME: FINDINGS FROM MULTIMODAL IMAGING AND ELECTROPHYSIOLOGY.

Journal article Retin Cases Brief Rep · May 1, 2022 BACKGROUND/PURPOSE: Poretti-Boltshauser syndrome is a rare, nonprogressive neurologic syndrome with characteristic cerebellar cysts on neuroimaging due to mutations in LAMA1. The ophthalmic findings in Poretti-Boltshauser syndrome are not well described. H ... Full text Link to item Cite

Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

Journal article Br J Ophthalmol · May 2022 BACKGROUND: The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown. METHODS: We manually segmented GA in 210 eyes with GA involving ... Full text Link to item Cite

MULTIMODAL ASSESSMENTS OF DRUSENOID PIGMENT EPITHELIAL DETACHMENTS IN THE AGE-RELATED EYE DISEASE STUDY 2 ANCILLARY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY STUDY COHORT.

Journal article Retina · May 1, 2022 PURPOSE: To identify features correlating with drusenoid pigment epithelial detachment (DPED) progression in the Age-Related Eye Disease Study 2 Ancillary spectral-domain optical coherence tomography study cohort. METHODS: In this retrospective analysis of ... Full text Link to item Cite

Predominantly Persistent Subretinal Fluid in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmol Retina · October 2021 OBJECTIVE: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and to compare visual acuity (VA) to eyes with nonpersistent SRF. DESIGN: Cohort within ran ... Full text Link to item Cite

International Classification of Retinopathy of Prematurity, Third Edition.

Journal article Ophthalmology · October 2021 PURPOSE: The International Classification of Retinopathy of Prematurity is a consensus statement that creates a standard nomenclature for classification of retinopathy of prematurity (ROP). It was initially published in 1984, expanded in 1987, and revisite ... Full text Link to item Cite

Evaluating the association of clinical factors and optical coherence tomography retinal imaging with axial length and axial length growth among preterm infants.

Journal article Graefes Arch Clin Exp Ophthalmol · September 2021 PURPOSE: To study the association of clinical factors and optical coherence tomography (OCT) retinal imaging with axial length (AL) and AL growth in preterm infants METHODS: Among a subgroup of infants from the prospective BabySTEPS study who were screened ... Full text Link to item Cite

Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography.

Journal article Transl Vis Sci Technol · August 2, 2021 PURPOSE: To establish methods to visualize depth-resolved perifoveal retinal vasculature in preterm infants using handheld optical coherence tomography angiography (OCT-A). METHODS: In this exploratory study, eyes of preterm infants were imaged using an in ... Full text Link to item Cite

Relationship of Topographic Distribution of Geographic Atrophy to Visual Acuity in Nonexudative Age-Related Macular Degeneration.

Journal article Ophthalmol Retina · August 2021 PURPOSE: To investigate the topographic distribution of geographic atrophy (GA) and to identify an anatomic endpoint that correlates with visual acuity (VA) in eyes with GA. DESIGN: Retrospective analysis of a multicenter, prospective, randomized controlle ... Full text Link to item Cite

Macular OCT Characteristics at 36 Weeks' Postmenstrual Age in Infants Examined for Retinopathy of Prematurity.

Journal article Ophthalmol Retina · June 2021 PURPOSE: To report our ability to capture,-grade reliably, and analyze bedside macular OCT images from preterm infants and relate OCT findings to biological factors and retinopathy of prematurity (ROP) status at a single time window in the Study of Eye Ima ... Full text Link to item Cite

Microscope-Integrated OCT-Guided Volumetric Measurements of Subretinal Blebs Created by a Suprachoroidal Approach.

Journal article Transl Vis Sci Technol · June 1, 2021 PURPOSE: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography ... Full text Link to item Cite

Systemic Factors Associated with a Thinner Choroid in Preterm Infants.

Journal article Ophthalmol Sci · June 2021 PURPOSE: To identify systemic health factors associated with a thinner choroid, which has been hypothesized as a cause of poor visual outcomes in low-birth weight infants. DESIGN: The prospective, observational Study of Eye Imaging in Preterm Infants (Baby ... Full text Link to item Cite

Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.

Journal article Ophthalmol Retina · May 2021 PURPOSE: In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-r ... Full text Link to item Cite

Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity.

Journal article JAMA Ophthalmol · May 1, 2021 IMPORTANCE: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. OBJECTIVE: To compare stress during investigational optical coherence tomography (OCT) imaging to ... Full text Link to item Cite

COMBINED INTERNAL LIMITING MEMBRANE FLAP AND AUTOLOGOUS PLASMA CONCENTRATE TO CLOSE A LARGE TRAUMATIC MACULAR HOLE IN A PEDIATRIC PATIENT.

Journal article Retin Cases Brief Rep · March 1, 2021 PURPOSE: To describe a case of a large, traumatic macular hole in a pediatric patient closed using an internal limiting membrane flap in combination with autologous plasma concentrate (APC). METHODS: Description of a surgical technique as performed in one ... Full text Link to item Cite

Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Am J Ophthalmol · March 2021 PURPOSE: To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-vascular endothelial growth factor through pixel-mapping analysis of baseline optical coherence tomography (OCT). METHODS: Design: Cross-sectional a ... Full text Link to item Cite

Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.

Journal article Am J Ophthalmol · February 2021 PURPOSE: To assess retinal nerve fiber layer (RNFL) thickness in preterm infants. DESIGN: Prospective observational study. METHODS: We imaged 83 awake infants (159 eyes) at 36 ± 1 weeks postmenstrual age (defined as the time elapsed between the first day o ... Full text Link to item Cite

Foveal Differentiation and Inner Retinal Displacement Are Arrested in Extremely Premature Infants.

Journal article Invest Ophthalmol Vis Sci · February 1, 2021 PURPOSE: Children with a history of prematurity often have poorly developed foveae but when during development foveal differences arise. We hypothesize that the course of foveal development is altered from the time of preterm birth. METHODS: Eyes of 102 pr ... Full text Link to item Cite

Lightweight Learning-Based Automatic Segmentation of Subretinal Blebs on Microscope-Integrated Optical Coherence Tomography Images.

Journal article Am J Ophthalmol · January 2021 PURPOSE: Subretinal injections of therapeutics are commonly used to treat ocular diseases. Accurate dosing of therapeutics at target locations is crucial but difficult to achieve using subretinal injections due to leakage, and there is no method available ... Full text Link to item Cite

An Evaluation of the Microvasculature of Macular Nodules in Coats Disease Using Optical Coherence Tomography Angiography: A Report of 3 Cases.

Journal article J Vitreoretin Dis · 2021 PURPOSE: This work aimed to examine the microvasculature of macular fibrosis in Coats disease. METHODS: Three boys (aged 3, 4, and 6 years) with Coats disease (stages 2B to 3A2) and macular fibrotic nodules were imaged using optical coherence tomography an ... Full text Link to item Cite

HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS OF X-LINKED RETINOSCHISIS IN EARLY CHILDHOOD.

Journal article Retina · October 2020 BACKGROUND/PURPOSE: Using handheld spectral domain optical coherence tomography (SDOCT) imaging to investigate in vivo microanatomic retinal changes and their progression over time in young children with juvenile X-linked retinoschisis (XLRS). METHODS: Thi ... Full text Link to item Cite

Morphological characteristics of early- versus late-onset macular edema in preterm infants.

Journal article J AAPOS · October 2020 Macular images of infants with early-onset edema (occurring at or before 33 weeks' postmenstrual age [PMA]) and infants with late-onset edema (at or after 36 weeks' PMA) were compared. At first appearance, early-onset edema has a more severe morphology, wi ... Full text Link to item Cite

Slow progressive perifoveal vascular formation in an infant with aggressive posterior retinopathy of prematurity.

Journal article J AAPOS · October 2020 Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of ROP occurring in preterm infants that is characterized by rapid progression and prominent vascularity. We report the use of investigational bedside noninvasive optical coherence t ... Full text Link to item Cite

Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System.

Journal article Transl Vis Sci Technol · October 2020 PURPOSE: To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. METHODS: Graders measured central foveal thickness (CFT), optic nerve-t ... Full text Link to item Cite

Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy.

Journal article Graefes Arch Clin Exp Ophthalmol · September 2020 PURPOSE: To detect retinal features and abnormalities on optical coherence tomography (OCT) without pupil dilation and relate these to brain injury in infants with a clinical diagnosis of hypoxic ischemic encephalopathy (HIE). METHODS: Under an institution ... Full text Link to item Cite

Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients.

Journal article J AAPOS · August 2020 Handheld optical coherence tomography (OCT) makes it possible to acquire intraoperative and clinical imaging in infants and children for whom standard OCT is not possible. In patients with a retinal pathology who are left aphakic after surgery, however, im ... Full text Link to item Cite

Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity.

Journal article Transl Vis Sci Technol · August 2020 PURPOSE: To describe the creation of en face retinal vessel shadow view (RVSV) optical coherence tomography (OCT) images and assess the feasibility of using these for evaluating vascular disease in preterm infants at risk for retinopathy of prematurity (RO ... Full text Link to item Cite

Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial.

Journal article JAMA Ophthalmol · May 1, 2020 IMPORTANCE: Retinal hypopigmentation and hyperpigmentation are precursors of geographic atrophy (GA). Incidence and progression to GA in eyes treated with anti-vascular endothelial growth factor for neovascular age-related macular degeneration (nAMD) have ... Full text Link to item Cite

Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration: Two-Year Results.

Journal article Ophthalmology · April 2020 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

Characteristics of Eyes With Good Visual Acuity at 5 Years After Initiation of Treatment for Age-Related Macular Degeneration but Not Receiving Treatment From Years 3 to 5: Post Hoc Analysis of the CATT Randomized Clinical Trial.

Journal article JAMA Ophthalmol · March 1, 2020 IMPORTANCE: Identifying the characteristics of eyes with neovascular age-related macular degeneration (nAMD) that maintain good vision without anti-vascular endothelial growth factor treatment for at least 3 years after management, as occurred in the Compa ... Full text Link to item Cite

Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.

Journal article Graefes Arch Clin Exp Ophthalmol · January 2020 PURPOSE: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be ... Full text Link to item Cite

Assessment of Macular Microvasculature in Healthy Eyes of Infants and Children Using OCT Angiography.

Journal article Ophthalmology · December 2019 PURPOSE: To assess macular vasculature in healthy infants and children using OCT angiography (OCTA). DESIGN: Prospective cross-sectional study. PARTICIPANTS: One hundred thirty-five normal maculae of 89 healthy infants and children (mean age, 8.5±5.3 years ... Full text Open Access Link to item Cite

Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA.

Journal article Ophthalmic Surg Lasers Imaging Retina · December 1, 2019 BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single- ... Full text Link to item Cite

Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years of Age.

Journal article Am J Ophthalmol · November 2019 PURPOSE: Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) ... Full text Link to item Cite

Association Between Cilioretinal Arteries and Advanced Age-Related Macular Degeneration: Secondary Analysis of the Comparison of Age-Related Macular Degeneration Treatment Trials (CATT).

Journal article JAMA Ophthalmol · November 1, 2019 IMPORTANCE: Recent reports suggest that cilioretinal arteries (CRAs) confer protection against developing advanced age-related macular degeneration (AMD). OBJECTIVE: To further characterize the association between the presence of a CRA and incidence of geo ... Full text Link to item Cite

Neuroretinal Imaging Inflammatory Biomarkers Anticipating Radiation-Induced Macular Edema.

Journal article Retina · October 2019 Full text Link to item Cite

Capturing Macular Vascular Development in an Infant With Retinopathy of Prematurity.

Journal article JAMA Ophthalmol · September 1, 2019 Full text Link to item Cite

Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months.

Journal article Ophthalmol Retina · August 2019 PURPOSE: To report the 1-year progression of visual impairment on psychophysical tests of visual function in patients with early and intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS: Patients with ... Full text Link to item Cite

Blue Light Fundus Autofluorescence in Coats Disease.

Journal article Retina · August 2019 Full text Link to item Cite

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration.

Journal article Nat Commun · July 26, 2019 Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form. He ... Full text Link to item Cite

Demonstration of anatomical development of the human macula within the first 5 years of life using handheld OCT.

Journal article Int Ophthalmol · July 2019 PURPOSE: To demonstrate the anatomical development of the human macula using handheld spectral domain optical coherence tomography (SD-OCT) during the first 5 years of life. METHODS: This study is a cross-sectional, observational case series. Thirty-five n ... Full text Link to item Cite

Retinal Degeneration After Accidental Intravitreal Injection of Ropivacaine During Strabismus Surgery.

Journal article Retina · July 2019 Full text Link to item Cite

Choriovitreal Neovascularization After Resolution of Infectious Chorioretinitis.

Journal article Retina · June 2019 This report describes the first documented case of choriovitreal neovascularization (CVNV) occurring after infectious chorioretinitis, with OCT-angiography (OCT-A) demonstrating flow through the vitreal portion of the lesion, and response to anti-VEGF ther ... Full text Link to item Cite

Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · May 2019 PURPOSE: To describe changes in visual acuity (VA) and macular morphologic features at 5 years in eyes with nonfibrotic scar (NFS) identified at 1 year in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective coho ... Full text Link to item Cite

Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging.

Journal article Biomed Opt Express · May 1, 2019 OCT angiography is a functional extension of OCT that allows for non-invasive imaging of retinal microvasculature. However, most current OCT angiography systems are tabletop systems that are typically used for imaging compliant, seated subjects. These syst ... Full text Link to item Cite

Macular Microvascular Findings in Familial Exudative Vitreoretinopathy on Optical Coherence Tomography Angiography.

Journal article Ophthalmic Surg Lasers Imaging Retina · May 1, 2019 BACKGROUND AND OBJECTIVE: To describe depth-resolved macular microvasculature abnormalities in patients with familial exudative vitreoretinopathy (FEVR) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Twenty-two eyes (11 eyes o ... Full text Link to item Cite

Best Clinical Practice for Age-Related Macular Degeneration Imaging

Journal article Journal of Vitreoretinal Diseases · May 1, 2019 Purpose: To identify best clinical practices for macular degeneration imaging. Methods: We reviewed best clinical practices for imaging patients with age-related macular degeneration. These recommendations are based on different levels of evidence (I-III). ... Full text Cite

Three-dimensional pattern of extraretinal neovascular development in retinopathy of prematurity.

Journal article Graefes Arch Clin Exp Ophthalmol · April 2019 BACKGROUND: The application of three-dimensional (3D) visualization techniques to evaluate the earliest visible onset of abnormal retinal vascular development in preterm infants with retinopathy of prematurity (ROP), using bedside non-contact optical coher ... Full text Link to item Cite

Distribution of OCT Features within Areas of Macular Atrophy or Scar after 2 Years of Anti-VEGF Treatment for Neovascular AMD in CATT.

Journal article Ophthalmol Retina · April 2019 PURPOSE: Macular atrophy and scar increase in prevalence during treatment for neovascular age-related macular degeneration and are associated with poor visual acuity. We sought to identify the distribution of spectral-domain OCT (SD-OCT)-determined feature ... Full text Link to item Cite

Experimental Evidence Behind Clinical Trial Outcomes in Retinopathy of Prematurity.

Journal article Ophthalmic Surg Lasers Imaging Retina · April 1, 2019 Treatment of severe retinopathy of prematurity (ROP) has evolved over the last decade. This article reviews recent clinical trials and experimental evidence that supports clinical outcomes and observations, including the efficacy of anti-vascular endotheli ... Full text Link to item Cite

Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials.

Journal article JAMA Ophthalmol · March 1, 2019 IMPORTANCE: To facilitate drug and device development for neonates, the International Neonatal Consortium brings together key stakeholders, including pharmaceutical companies, practitioners, regulators, funding agencies, scientists, and families, to addres ... Full text Link to item Cite

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17.

Journal article Ophthalmology · February 2019 PURPOSE: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). DESIGN: Retrospective analysis of a prospective cohort study. PARTICIPANTS: Of th ... Full text Link to item Cite

Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease.

Journal article JAMA Ophthalmol · February 1, 2019 IMPORTANCE: Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. OBJECTIVE: To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic fin ... Full text Link to item Cite

Vascular Findings in a Small Retinoblastoma Tumor Using OCT Angiography.

Journal article Ophthalmol Retina · February 2019 Full text Link to item Cite

LONGITUDINAL CHANGES IN THE OPTIC NERVE HEAD AND RETINA OVER TIME IN VERY YOUNG CHILDREN WITH FAMILIAL EXUDATIVE VITREORETINOPATHY.

Journal article Retina · January 2019 PURPOSE: To explore vitreoretinal pathologies and their longitudinal changes visible on handheld optical coherence tomography (OCT) of young children with familial exudative vitreoretinopathy. METHODS: The authors retrospectively analyzed handheld OCT imag ... Full text Link to item Cite

Imaging Infant Retinal Vasculature with OCT Angiography.

Journal article Ophthalmol Retina · January 2019 Full text Link to item Cite

Subfoveal Lucency after Treatment of Vitreomacular Traction without Macular Hole in the Phase 3 Trials of Ocriplasmin Vitreolysis.

Journal article Ophthalmol Retina · January 2019 PURPOSE: To describe the clinical impact of subfoveal lucency (SFL) seen on OCT before and after treatment of vitreomacular traction (VMT) or symptomatic vitreomacular adhesion (VMA) without macular hole (MH) in the prospective phase 3 trials of ocriplasmi ... Full text Link to item Cite

Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants.

Journal article PLoS One · 2019 PURPOSE: Central foveal thickness (CFT) measurements from optical coherence tomography (OCT) scans provide a precise measure of severity of pathologic changes in the fovea, progress of disease and response to treatment. Although these measures are addition ... Full text Link to item Cite

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

Journal article Ophthalmology · December 2018 PURPOSE: To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN: Prospective cohort study withi ... Full text Link to item Cite

Visualizing Macular Microvasculature Anomalies in 2 Infants With Treated Retinopathy of Prematurity.

Journal article JAMA Ophthalmol · December 1, 2018 Full text Link to item Cite

Deep learning for retinopathy of prematurity screening.

Journal article Br J Ophthalmol · November 23, 2018 Full text Link to item Cite

Depth-Based, Motion-Stabilized Colorization of Microscope-Integrated Optical Coherence Tomography Volumes for Microscope-Independent Microsurgery.

Journal article Transl Vis Sci Technol · November 2018 PURPOSE: We develop and assess the impact of depth-based, motion-stabilized colorization (color) of microscope-integrated optical coherence tomography (MIOCT) volumes on microsurgical performance and ability to interpret surgical volumes. METHODS: Color wa ... Full text Link to item Cite

Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal article Optica · September 20, 2018 Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subje ... Full text Link to item Cite

VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY.

Journal article Retina · September 2018 PURPOSE: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. METHODS: In this prospective study, we analyzed a subgro ... Full text Link to item Cite

Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Journal article Ophthalmol Retina · September 2018 PURPOSE: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic en face viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascul ... Full text Link to item Cite

HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS.

Journal article Retina · August 2018 PURPOSE: The authors investigated feasibility of undilated handheld spectral domain optical coherence tomography (SDOCT) retinal imaging in preterm infants and children with neurologic abnormalities. METHODS: Under an institutional review board-approved pr ... Full text Link to item Cite

Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · July 2018 PURPOSE: To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Multicenter, prospective cohort study. PARTICIPANTS: A total of 1061 s ... Full text Link to item Cite

Baseline Predictors for Five-Year Visual Acuity Outcomes in the Comparison of AMD Treatment Trials.

Journal article Ophthalmol Retina · June 2018 PURPOSE: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). DESIGN: Secondary analysis of data from a cohort study. P ... Full text Link to item Cite

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease.

Journal article Invest Ophthalmol Vis Sci · June 1, 2018 PURPOSE: To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. METHODS: Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 201 ... Full text Link to item Cite

Visual Function Metrics in Early and Intermediate Dry Age-related Macular Degeneration for Use as Clinical Trial Endpoints.

Journal article Am J Ophthalmol · May 2018 PURPOSE: To evaluate and quantify visual function metrics to be used as endpoints of age-related macular degeneration (AMD) stages and visual acuity (VA) loss in patients with early and intermediate AMD. DESIGN: Cross-sectional analysis of baseline data fr ... Full text Link to item Cite

Fluorescein Angiographic Characteristics of Macular Edema During Infancy.

Journal article JAMA Ophthalmol · May 1, 2018 IMPORTANCE: Macular edema during infancy, a subclinical feature identified in premature infants by handheld spectral-domain optical coherence tomography (SD-OCT), has been associated with poorer visual acuity and neurodevelopmental outcomes. Features of ma ... Full text Link to item Cite

Real-Time Volumetric Imaging of Vitreoretinal Surgery with a Prototype Microscope-Integrated Swept-Source OCT Device.

Journal article Ophthalmol Retina · May 2018 PURPOSE: To evaluate the images produced in an initial surgical series of intraoperative near-real-time volumetric swept-source (SS) OCT imaging. DESIGN: Prospective translational study. PARTICIPANTS: Forty-one consecutive adult patients undergoing vitreor ... Full text Link to item Cite

Four-Dimensional Microscope-Integrated OCT Use in Argus II Placement.

Journal article Ophthalmol Retina · May 2018 Full text Link to item Cite

Linking OCT, Angiographic, and Photographic Lesion Components in Neovascular Age-Related Macular Degeneration.

Journal article Ophthalmol Retina · May 2018 PURPOSE: To develop methods to make precise comparisons of specific retinal features between and within spectral-domain (SD) OCT images, color fundus photography (CFP) images, and fluorescein angiography (FA) images in eyes treated with anti-vascular endot ... Full text Link to item Cite

Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography.

Journal article Transl Vis Sci Technol · April 2018 PURPOSE: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. METHODS: A MIOCT image-based vo ... Full text Link to item Cite

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.

Journal article Invest Ophthalmol Vis Sci · January 1, 2018 PURPOSE: To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). METHODS: Cross-sectional study of subjects with early AMD Age ... Full text Link to item Cite

Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology.

Journal article Transl Vis Sci Technol · October 2017 PURPOSE: We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. METHODS: A prototype swept source OCT system ... Full text Link to item Cite

Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience.

Journal article Ophthalmology · September 2017 PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ... Full text Link to item Cite

Intra-operative microscope-integrated swept-source optical coherence tomography guided placement of Argus II retinal prosthesis.

Journal article Acta Ophthalmol · August 2017 Full text Link to item Cite

ASSESSMENT OF THE RETINAL STRUCTURE IN CHILDREN WITH INCONTINENTIA PIGMENTI.

Journal article Retina · August 2017 PURPOSE: This report aims at expanding the current knowledge of retinal microanatomy in children with incontinentia pigmenti using hand-held spectral domain optical coherence tomography (SDOCT). METHODS: We reviewed OCT scans from 7 children (4 weeks-13 ye ... Full text Link to item Cite

Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease.

Journal article JAMA Ophthalmol · May 1, 2017 IMPORTANCE: Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal di ... Full text Link to item Cite

Correspondence.

Journal article Retina · May 2017 Full text Link to item Cite

Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence Tomography-Guided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma.

Journal article Retina · April 2017 PURPOSE: We describe two cases of intraoperative 4D microscope–integrated swept source optical coherence tomography (4D MIOCT) guided 27-gauge transvitreal retinochoroidal biopsy for choroidal melanoma. METHODS: Two 68-year-old females with choroidal melan ... Full text Link to item Cite

Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group.

Journal article Ophthalmology · April 2017 PURPOSE: To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen) ... Full text Link to item Cite

Review of intraoperative optical coherence tomography: technology and applications [Invited].

Journal article Biomed Opt Express · March 1, 2017 During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon's depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resec ... Full text Link to item Cite

Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery.

Journal article J Pediatr Ophthalmol Strabismus · February 14, 2017 The authors report the use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT), capable of live four-dimensional (three-dimensional across time) intraoperative imaging, to directly visualize suture depth during lateral rectus rese ... Full text Link to item Cite

Association of Pediatric Choroidal Neovascular Membranes at the Temporal Edge of Optic Nerve and Retinochoroidal Coloboma.

Journal article Am J Ophthalmol · February 2017 PURPOSE: To describe the characteristics of pediatric choroidal neovascular membranes (CNVs) associated with retinochoroidal and optic nerve coloboma using optical coherence tomography (OCT) and their response to treatment. DESIGN: Retrospective case serie ... Full text Link to item Cite

Incidence and Growth of Geographic Atrophy during 5 Years of Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · January 2017 PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PART ... Full text Link to item Cite

Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries.

Journal article Indian J Ophthalmol · January 2017 We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculecto ... Full text Link to item Cite

Visual and Morphologic Outcomes in Eyes with Hard Exudate in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmol Retina · 2017 PURPOSE: To compare baseline characteristics, visual acuity (VA) and morphological outcomes between eyes with baseline hard exudates (HE) and all other eyes among patients with neovascular age-related macular degeneration (NVAMD) treated with anti-vascular ... Full text Link to item Cite

Intraocular Pressure and Big Bubble Diameter in Deep Anterior Lamellar Keratoplasty: An Ex-Vivo Microscope-Integrated OCT With Heads-Up Display Study.

Journal article Asia Pac J Ophthalmol (Phila) · 2017 PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artifi ... Full text Link to item Cite

Recovery of Foveal Anatomy and Subfoveal Lucency after Pharmacologic and Surgical Macular Hole Closure in the Ocriplasmin Phase III Trials.

Journal article Ophthalmol Retina · 2017 PURPOSE: To compare foveal anatomic features on OCT after macular hole (MH) closure, and their association with visual function, in the ocriplasmin phase III trials. DESIGN: Randomized clinical trial. PARTICIPANTS: One hundred fifty-three participants. MET ... Full text Link to item Cite

Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.

Journal article Ophthalmology · December 2016 PURPOSE: Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tom ... Full text Link to item Cite

Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study.

Journal article Cornea · November 2016 PURPOSE: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). METHODS: The DALK ... Full text Link to item Cite

Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging.

Journal article Opt Lett · November 1, 2016 Young and/or autistic children cannot be imaged with tabletop or handheld optical coherence tomography (OCT) because of their lack of attention and fear of large objects close to their face. We demonstrate a prototype retinal swept-source OCT system with a ... Full text Link to item Cite

Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography.

Journal article Sci Rep · August 19, 2016 Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. W ... Full text Open Access Link to item Cite

Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · August 2016 PURPOSE: To describe outcomes 5 years after initiating treatment with bevacizumab or ranibizumab for neovascular age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: Patients enrolled in the Comparison of AMD Treatments Trials. METHO ... Full text Link to item Cite

Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.

Journal article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, ... Full text Link to item Cite

Optical Coherence Tomography for Retinal Surgery: Perioperative Analysis to Real-Time Four-Dimensional Image-Guided Surgery.

Journal article Invest Ophthalmol Vis Sci · July 1, 2016 Magnification of the surgical field using the operating microscope facilitated profound innovations in retinal surgery in the 1970s, such as pars plana vitrectomy. Although surgical instrumentation and illumination techniques are continually developing, th ... Full text Link to item Cite

Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.

Journal article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. ME ... Full text Link to item Cite

Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article JAMA Ophthalmol · June 1, 2016 IMPORTANCE: Single-nucleotide polymorphisms (SNPs) associated with the CFH, ARMS2, C3, LIPC, CFB, and C2 genes are associated with age-related macular degeneration (AMD); however, the association of these SNPs with angiographic features of neovascular AMD ... Full text Link to item Cite

VISUAL FUNCTION MEASURES IN EARLY AND INTERMEDIATE AGE-RELATED MACULAR DEGENERATION.

Journal article Retina · May 2016 PURPOSE: The objectives of this study were to evaluate 1) the feasibility of performing computerized tests of low luminance visual acuity (LLVA), cone-specific contrast (Cone Contrast Test [CCT]), contrast sensitivity, and microperimetry and 2) the test-re ... Full text Link to item Cite

Relating Retinal Morphology and Function in Aging and Early to Intermediate Age-related Macular Degeneration Subjects.

Journal article Am J Ophthalmol · May 2016 PURPOSE: To evaluate relationships between age-related macular degeneration (AMD) morphology on spectral-domain optical coherence tomography (SDOCT) and visual function. DESIGN: Cross-sectional, observational. METHODS: From the Alabama Study on Early AMD b ... Full text Link to item Cite

Novel microscope-integrated stereoscopic heads-up display for intrasurgical optical coherence tomography.

Journal article Biomed Opt Express · May 1, 2016 Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) syste ... Full text Link to item Cite

Enhanced volumetric visualization for real time 4D intraoperative ophthalmic swept-source OCT.

Journal article Biomed Opt Express · May 1, 2016 Current-generation software for rendering volumetric OCT data sets based on ray casting results in volume visualizations with indistinct tissue features and sub-optimal depth perception. Recent developments in hand-held and microscope-integrated intrasurgi ... Full text Link to item Cite

Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · April 2016 PURPOSE: To describe the association between morphologic features on fundus photography (FP), fluorescein angiography (FA), and optical coherence tomography (OCT) and visual acuity (VA) in the second year of the Comparison of Age-related Macular Degenerati ... Full text Link to item Cite

Angiographic Cystoid Macular Edema and Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · April 2016 PURPOSE: To describe morphologic and visual outcomes in eyes with angiographic cystoid macular edema (CME) treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (nAMD). DESIGN: Prospective cohort study within a randomized ... Full text Link to item Cite

Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration.

Journal article Ophthalmology · January 2016 PURPOSE: To analyze the value of novel measures of retinal pigment epithelium-drusen complex (RPEDC) volume to predict 2-year disease progression of intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS ... Full text Link to item Cite

MACULAR PSEUDO-HOLE IN SHAKEN BABY SYNDROME: UNDERSCORING THE UTILITY OF OPTICAL COHERENCE TOMOGRAPHY UNDER ANESTHESIA.

Journal article Retin Cases Brief Rep · 2016 PURPOSE: To describe a case of vitrectomy for nonclearing vitreous hemorrhage in shaken baby syndrome and the utility of intraoperative hand-held optical coherence tomography to distinguish a macular hole from a pseudo-hole. METHODS: Case report of a 4-mon ... Full text Link to item Cite

Optical coherence tomography of the preterm eye: from retinopathy of prematurity to brain development.

Journal article Eye Brain · 2016 Preterm infants with retinopathy of prematurity are at increased risk of poor neurodevelopmental outcomes. Because the neurosensory retina is an extension of the central nervous system, anatomic abnormalities in the anterior visual pathway often relate to ... Full text Link to item Cite

In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe.

Journal article Nat Photonics · 2016 Full text Link to item Cite

Thinner Retinal Nerve Fiber Layer in Very Preterm Versus Term Infants and Relationship to Brain Anatomy and Neurodevelopment.

Journal article Am J Ophthalmol · December 2015 PURPOSE: To assess retinal nerve fiber layer (RNFL) thickness at term-equivalent age in very preterm (<32 weeks gestational age) vs term-born infant cohorts, and compare very preterm infant RNFL thickness with brain anatomy and neurodevelopment. DESIGN: Co ... Full text Link to item Cite

Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).

Journal article Ophthalmology · December 2015 PURPOSE: To evaluate the association of baseline characteristics and early visual acuity (VA) response with visual outcomes at years 1 or 2 in the Comparison of Age-Related Macular Degeneration (AMD) Treatments Trials (CATT). DESIGN: Secondary analysis of ... Full text Link to item Cite

FUNCTIONAL OUTCOMES OF YOUNG INFANTS WITH AND WITHOUT MACULAR EDEMA.

Journal article Retina · October 2015 PURPOSE: The authors relate posterior segment microanatomy from perinatal spectral domain optical coherence tomography to visual acuity, brain abnormalities, and neurodevelopment. METHODS: Thirteen infants (11 preterm and 2 term birth), imaged in the nurse ... Full text Link to item Cite

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · September 2015 PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective cohort study w ... Full text Link to item Cite

INTRAOPERATIVE SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING AFTER INTERNAL LIMITING MEMBRANE PEELING IN IDIOPATHIC EPIRETINAL MEMBRANE WITH CONNECTING STRANDS.

Journal article Retina · August 2015 PURPOSE: To report the intraoperative optical coherence tomography findings in idiopathic epiretinal membrane (ERM) with connecting strands and to describe the postoperative outcomes. METHODS: A retrospective, case series study within a prospective observa ... Full text Link to item Cite

IDENTIFICATION OF FLUID ON OPTICAL COHERENCE TOMOGRAPHY BY TREATING OPHTHALMOLOGISTS VERSUS A READING CENTER IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENTS TRIALS.

Journal article Retina · July 2015 PURPOSE: To examine treatment decisions by ophthalmologists versus reading center fluid identification from optical coherence tomography in Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). METHODS: Fluid in 6,210 optical coherence t ... Full text Link to item Cite

Intrasurgical Human Retinal Imaging With Manual Instrument Tracking Using a Microscope-Integrated Spectral-Domain Optical Coherence Tomography Device.

Journal article Transl Vis Sci Technol · July 2015 PURPOSE: To characterize the first in-human intraoperative imaging using a custom prototype spectral-domain microscope-integrated optical coherence tomography (MIOCT) device during vitreoretinal surgery with instruments in the eye. METHODS: Under instituti ... Full text Link to item Cite

Association between anatomical resolution and functional outcomes in the mivi-trust studies using ocriplasmin to treat symptomatic vitreomacular adhesion/vitreomacular traction, including when associated with macular hole.

Journal article Retina · June 2015 PURPOSE: To evaluate visual function in patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction including when associated with macular hole after ocriplasmin treatment, and the association between resolution of the underlying conditio ... Full text Link to item Cite

Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · June 2015 OBJECTIVE: To assess the association of the vitreomacular interface with outcomes of eyes treated with anti-vascular endothelial growth factor drugs for neovascular age-related macular degeneration (AMD). DESIGN: Prospective cohort study within a multicent ... Full text Link to item Cite

Relationship of central choroidal thickness with age-related macular degeneration status.

Journal article Am J Ophthalmol · April 2015 PURPOSE: To compare choroidal thickness in patients with intermediate or advanced age-related macular degeneration (AMD) and control subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT). DESIGN: Retrospective cross-sectional study o ... Full text Link to item Cite

Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.

Journal article Am J Ophthalmol · April 2015 PURPOSE: To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates. DESIGN: Descriptive research to develop normative data. METHODS: Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-h ... Full text Link to item Cite

Delay in retinal photoreceptor development in very preterm compared to term infants.

Journal article Invest Ophthalmol Vis Sci · January 13, 2015 PURPOSE: We compared photoreceptor development from spectral domain optical coherence tomography (SD-OCT) imaging in very preterm infants (VPT, <32 weeks gestational age) with those of term infants. METHODS: The microanatomy of foveal SD-OCT images obtaine ... Full text Link to item Cite

Efficacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials.

Journal article Ophthalmology · January 2015 PURPOSE: To evaluate the efficacy of a single intravitreal injection of ocriplasmin 125 μg across relevant subpopulations of patients with symptomatic vitreomacular adhesion (VMA)/vitreomacular traction (VMT), including when associated with macular hole. D ... Full text Link to item Cite

Retinal Imaging of Infants on Spectral Domain Optical Coherence Tomography.

Journal article Biomed Res Int · 2015 Spectral domain coherence tomography (SD OCT) has become an important tool in the management of pediatric retinal diseases. It is a noncontact imaging device that provides detailed assessment of the microanatomy and pathology of the infant retina with a sh ... Full text Link to item Cite

Evaluation of optic nerve development in preterm and term infants using handheld spectral-domain optical coherence tomography.

Journal article Ophthalmology · September 2014 PURPOSE: To evaluate effects of prematurity on early optic nerve (ON) development and the usefulness of ON parameters as indicators of central nervous system (CNS) development and pathology. DESIGN: Prospective, cross-sectional, longitudinal study. PARTICI ... Full text Link to item Cite

Diagnostic and therapeutic challenges.

Journal article Retina · June 2014 Full text Link to item Cite

Ocular safety of recreational lasers.

Journal article JAMA Ophthalmol · March 2014 Full text Link to item Cite

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3.

Journal article JAMA Ophthalmol · February 2014 IMPORTANCE: The Age-Related Eye Disease Study (AREDS) formulation for the treatment of age-related macular degeneration (AMD) contains vitamin C, vitamin E, beta carotene, and zinc with copper. The Age-Related Eye Disease Study 2 (AREDS2) assessed the valu ... Full text Link to item Cite

Characterization of the choroid-scleral junction and suprachoroidal layer in healthy individuals on enhanced-depth imaging optical coherence tomography.

Journal article JAMA Ophthalmol · February 2014 IMPORTANCE: Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to ... Full text Link to item Cite

Lateral and axial measurement differences between spectral-domain optical coherence tomography systems.

Journal article J Biomed Opt · January 2014 We assessed the reproducibility of lateral and axial measurements performed with spectral-domain optical coherence tomography (SDOCT) instruments from a single manufacturer and across several manufacturers. One human retina phantom was imaged on two instru ... Full text Link to item Cite

Risk of scar in the comparison of Age-related Macular Degeneration Treatments Trials

Journal article Ophthalmology · 2014 Cite

Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging.

Journal article Invest Ophthalmol Vis Sci · December 13, 2013 Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AM ... Full text Link to item Cite

Fully automatic software for retinal thickness in eyes with diabetic macular edema from images acquired by cirrus and spectralis systems.

Journal article Invest Ophthalmol Vis Sci · November 15, 2013 PURPOSE: To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral-domain optical coherence tomography (SD-OCT) images obtained from different commercia ... Full text Link to item Cite

Fast acquisition and reconstruction of optical coherence tomography images via sparse representation.

Journal article IEEE Trans Med Imaging · November 2013 In this paper, we present a novel technique, based on compressive sensing principles, for reconstruction and enhancement of multi-dimensional image data. Our method is a major improvement and generalization of the multi-scale sparsity based tomographic den ... Full text Link to item Cite

Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography.

Journal article J AAPOS · October 2013 PURPOSE: To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD ... Full text Link to item Cite

Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4.

Journal article JAMA Ophthalmol · July 2013 IMPORTANCE: Age-related cataract is a leading cause of visual impairment in the United States. The prevalence of age-related cataract is increasing, with an estimated 30.1 million Americans likely to be affected by 2020. OBJECTIVE: To determine whether dai ... Full text Link to item Cite

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

Journal article Invest Ophthalmol Vis Sci · June 14, 2013 PURPOSE: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal devel ... Full text Link to item Cite

Optical coherence tomography in retinopathy of prematurity: looking beyond the vessels.

Journal article Clin Perinatol · June 2013 Featured Work Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness in the United States. Optical Coherence Tomography (OCT) is a relatively new imaging technology capable of imaging ocular structures in cross section at high resolution. We present ... Full text Link to item Cite

Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.

Journal article JAMA · May 15, 2013 IMPORTANCE: Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). Observa ... Full text Link to item Cite

Macular findings in healthy full-term Hispanic newborns observed by hand-held spectral-domain optical coherence tomography.

Journal article Ophthalmic Surg Lasers Imaging Retina · 2013 BACKGROUND AND OBJECTIVE: To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns. PATIENTS AND METHODS: In thi ... Full text Link to item Cite

Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials.

Journal article Ophthalmology · December 2012 OBJECTIVE: To report reading center reproducibility during grading of Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA) images obtained during the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Pr ... Full text Link to item Cite

Histologic development of the human fovea from midgestation to maturity.

Journal article Am J Ophthalmol · November 2012 PURPOSE: To describe the histologic development of the human central retina from fetal week (Fwk) 22 to 13 years. DESIGN: Retrospective observational case series. METHODS: Retinal layers and neuronal substructures were delineated on foveal sections of fixe ... Full text Link to item Cite

Histologic development of the human fovea from midgestation to maturity.

Journal article American journal of ophthalmology · November 1, 2012 To describe the histologic development of the human central retina from fetal week (Fwk) 22 to 13 years. Retrospective observational case series. Retinal layers and neuronal substructures were delineated on foveal sections of fixed tissue stained in azure ... Cite

Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis.

Journal article Invest Ophthalmol Vis Sci · October 25, 2012 PURPOSE: To determine the relative ability of time domain (TD)-optical coherence tomography (OCT) compared with spectral domain (SD)-OCT to assess vitreoretinal interface abnormalities and pharmacologic treatment of symptomatic vitreomacular adhesion (VMA) ... Full text Link to item Cite

Characterization of vitreoretinal interface disorders using OCT in the interventional phase 3 trials of ocriplasmin.

Journal article Invest Ophthalmol Vis Sci · September 21, 2012 PURPOSE: We determined the reproducibility of a novel optical coherence tomography (OCT) protocol designed to evaluate formally vitreoretinal interface abnormalities on scans obtained during two phase 3 studies of intravitreal ocriplasmin to treat symptoma ... Full text Link to item Cite

Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD.

Journal article Invest Ophthalmol Vis Sci · July 9, 2012 PURPOSE: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tom ... Full text Link to item Cite

Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results.

Journal article Ophthalmology · July 2012 OBJECTIVE: To describe effects of ranibizumab and bevacizumab when administered monthly or as needed for 2 years and to describe the impact of switching to as-needed treatment after 1 year of monthly treatment. DESIGN: Multicenter, randomized clinical tria ... Full text Link to item Cite

Macular Edema in Premature Infants Reply

Journal article OPHTHALMOLOGY · June 1, 2012 Link to item Cite

Sparsity based denoising of spectral domain optical coherence tomography images.

Journal article Biomed Opt Express · May 1, 2012 In this paper, we make contact with the field of compressive sensing and present a development and generalization of tools and results for reconstructing irregularly sampled tomographic data. In particular, we focus on denoising Spectral-Domain Optical Coh ... Full text Link to item Cite

Automatic segmentation of closed-contour features in ophthalmic images using graph theory and dynamic programming.

Journal article Biomed Opt Express · May 1, 2012 This paper presents a generalized framework for segmenting closed-contour anatomical and pathological features using graph theory and dynamic programming (GTDP). More specifically, the GTDP method previously developed for quantifying retinal and corneal la ... Full text Link to item Cite

Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurity.

Journal article Arch Ophthalmol · May 2012 OBJECTIVE: To investigate whether the severity of cystoid macular edema (CME) in neonates who were 31 to 36 weeks' postmenstrual age, as viewed by spectral-domain optical coherence tomography (SD-OCT)imaging, predicts the severity of retinopathy of prematu ... Full text Link to item Cite

Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast.

Journal article Invest Ophthalmol Vis Sci · April 6, 2012 PURPOSE: This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical ... Full text Link to item Cite

Dislocation of the donor graft to the posterior segment in descemet stripping automated endothelial keratoplasty.

Journal article Am J Ophthalmol · April 2012 PURPOSE: To report a series of dislocations of the donor graft into the posterior segment associated with Descemet stripping endothelial keratoplasty (DSAEK) and to identify possible risk factors for dislocation and clinical outcomes. DESIGN: Retrospective ... Full text Link to item Cite

Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT images.

Journal article Invest Ophthalmol Vis Sci · January 5, 2012 PURPOSE: To automatically segment retinal spectral domain optical coherence tomography (SD-OCT) images of eyes with age-related macular degeneration (AMD) and various levels of image quality to advance the study of retinal pigment epithelium (RPE)+drusen c ... Full text Link to item Cite

Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography.

Journal article Am J Ophthalmol · January 2012 PURPOSE: To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. METHODS: Thirty-nine full-term newborn infants underwent dilated ret ... Full text Link to item Cite

Dynamics of human foveal development after premature birth.

Journal article Ophthalmology · December 2011 PURPOSE: To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Thirty-one prematurely born neonates, 9 ... Full text Link to item Cite

Analysis of pars plana vitrectomy for optic pit-related maculopathy with intraoperative optical coherence tomography: a possible connection with the vitreous cavity.

Journal article Arch Ophthalmol · November 2011 Optimal management of optic pit-related maculopathy remains to be determined. The fluid source for the maculopathy also remains controversial. In this article, we present a unique surgical technique for internal drainage of the intraretinal fluid and descr ... Full text Link to item Cite

Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degeneration.

Journal article Retina · September 2011 Featured Work PURPOSE: To directly assess the recovery of the retina overlying choroidal neovascularization in neovascular age-related macular degeneration and to understand the relationship between macular sensitivity and visual functional measures and retinal structur ... Full text Link to item Cite

Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity.

Journal article Retina · September 2011 Featured Work PURPOSE: To compare vitreoretinal pathology imaged with portable handheld spectral-domain optical coherence tomography (SD-OCT) to conventional indirect ophthalmoscopic examination in neonates undergoing screening for retinopathy of prematurity. METHODS: S ... Full text Link to item Cite

The use of optical coherence tomography in intraoperative ophthalmic imaging.

Journal article Ophthalmic Surg Lasers Imaging · July 2011 Optical coherence tomography (OCT) has transformed diagnostic ophthalmic imaging but until recently has been limited to the clinic setting. The development of spectral-domain OCT (SD-OCT), with its improved speed and resolution, along with the development ... Full text Link to item Cite

Errata

Journal article Retina · June 2011 Full text Cite

Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging.

Journal article Invest Ophthalmol Vis Sci · May 16, 2011 Featured Work PURPOSE: To demonstrate an operating microscope-mounted spectral domain optical coherence tomography (MMOCT) system for human retinal and model surgery imaging. METHODS: A prototype MMOCT system was developed to interface directly with an ophthalmic surgic ... Full text Link to item Cite

Reversible retinal edema in an infant with neonatal hemochromatosis and liver failure.

Journal article J AAPOS · February 2011 Featured Work We present a case of bilateral severe retinal edema with subretinal fluid in an infant diagnosed with neonatal hemochromatosis and liver failure. A macular cherry-red spot in each eye mimicked the clinical appearance of many metabolic storage diseases. Bot ... Full text Link to item Cite

Preretinal and intraretinal exudates in familial exudative vitreoretinopathy.

Journal article Retina · January 2011 Featured Work Full text Link to item Cite

Treatment of non-age-related macular degeneration submacular diseases with macular translocation surgery.

Journal article Retina · 2011 Featured Work PURPOSE: To evaluate the use of macular translocation surgery 360 in blinding submacular diseases other than age-related macular degeneration. METHODS: A retrospective, consecutive case review was performed of subjects treated with macular translocation su ... Full text Link to item Cite

Evaluation of contrast agents for enhanced visualization in optical coherence tomography.

Journal article Invest Ophthalmol Vis Sci · December 2010 Featured Work PURPOSE: To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. METHODS: Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were test ... Full text Link to item Cite

Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery.

Journal article Opt Lett · October 15, 2010 Featured Work We demonstrate in vivo human retinal imaging using an intraoperative microscope-mounted optical coherence tomography system (MMOCT). Our optomechanical design adapts an Oculus Binocular Indirect Ophthalmo Microscope (BIOM3), suspended from a Leica ophthalm ... Full text Open Access Link to item Cite

Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.

Journal article Invest Ophthalmol Vis Sci · October 2010 Featured Work PURPOSE: Spectral domain-optical coherence tomography (SD-OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were co ... Full text Link to item Cite

Efﬁcient fourier-wavelet super-resolution.

Journal article IEEE Trans Image Process · October 2010 Featured Work Super-resolution (SR) is the process of combining multiple aliased low-quality images to produce a high-resolution high-quality image. Aside from registration and fusion of low-resolution images, a key process in SR is the restoration and denoising of the ... Full text Link to item Cite

Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation.

Journal article Opt Express · August 30, 2010 Featured Work Segmentation of anatomical and pathological structures in ophthalmic images is crucial for the diagnosis and study of ocular diseases. However, manual segmentation is often a time-consuming and subjective process. This paper presents an automatic approach ... Full text Open Access Link to item Cite

Optimizing hand-held spectral domain optical coherence tomography imaging for neonates, infants, and children.

Journal article Invest Ophthalmol Vis Sci · May 2010 Featured Work PURPOSE: To describe age-related considerations and methods to improve hand-held spectral domain optical coherence tomography (HH-SD OCT) imaging of eyes of neonates, infants, and children. METHODS: Based on calculated optical parameters for neonatal and i ... Full text Link to item Cite

Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging.

Journal article Ophthalmology · December 2009 Featured Work PURPOSE: To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT). DESIGN: Prospective, observational case series. PARTICIPANTS: Three low-birth-weight, severely premature infants. ... Full text Link to item Cite

Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome.

Journal article Arch Ophthalmol · November 2009 Featured Work OBJECTIVE: To report a 3-generation white family clinically diagnosed variably with Wagner, Stickler, and Jansen syndromes and screened for sequence variants in the COL2A1 and CSPG2 genes. Wagner syndrome is an autosomal dominant vitreoretinopathy with a p ... Full text Link to item Cite

Spectral domain optical coherence tomography imaging of geographic atrophy margins.

Journal article Ophthalmology · September 2009 Featured Work OBJECTIVE: To test in vivo whether spectral domain optical coherence tomography (SD-OCT) provides adequate resolution for reproducible measurement of photoreceptor (PR) layer at the margins of geographic atrophy (GA), and if it delineates the relationship ... Full text Link to item Cite

Developing SDOCT to assess donor human eyes prior to tissue sectioning for research.

Journal article Graefes Arch Clin Exp Ophthalmol · August 2009 Featured Work BACKGROUND: To compare spectral domain optical coherence tomography (SDOCT) cross-sectional images of human central retina obtained from donor eyes with and without age-related macular degeneration (AMD) to corresponding histopathology from light micrograp ... Full text Link to item Cite

Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography.

Journal article Ophthalmology · March 2009 Featured Work PURPOSE: Detect changes in the neurosensory retina using spectral-domain optical coherence tomography (SD OCT) imaging over drusen in age-related macular degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of disease progression. D ... Full text Link to item Cite

Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device.

Journal article Am J Ophthalmol · February 2009 Featured Work PURPOSE: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS). DESIGN: Observational case series. METHODS: A novel SD OCT system was ... Full text Link to item Cite

Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomography.

Journal article Arch Ophthalmol · January 2009 Featured Work OBJECTIVES: To evaluate the spectrum of foveal architecture in pediatric albinism and to assess the utility of spectral-domain optical coherence tomography (OCT) in ocular imaging of children with nystagmus. METHODS: Spectral-domain OCT imaging was perform ... Full text Link to item Cite

Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery.

Journal article Retina · 2009 Featured Work PURPOSE: To describe the intraoperative use of handheld spectral domain optical coherence tomography (SDOCT) imaging in macular surgery. DESIGN: Prospective, observational case series. METHODS: A handheld SDOCT device was used to obtain preincision optical ... Full text Link to item Cite

Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration.

Journal article Ophthalmology · November 2008 Featured Work PURPOSE: To categorize drusen ultrastructure in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SDOCT) and correlate the tomographic and photographic drusen appearances. DESIGN: Prospective case series. PARTICIPAN ... Full text Link to item Cite

Correlation of pathologic features in spectral domain optical coherence tomography with conventional retinal studies.

Journal article Retina · February 2008 Featured Work PURPOSE: To delineate pathologic changes in retinal cross sections obtained with spectral (Fourier) domain optical coherence tomography (SDOCT), so that the findings are maintained when collapsed into a two-dimensional fundus image for comparison with conv ... Full text Link to item Cite

Quantifying vertical angle kappa after macular translocation surgery: a new use for the synoptophore.

Journal article Strabismus · 2008 Featured Work PURPOSE: To report the measurement of vertical angle kappa and its application in patients after full macular translocation (MT360) and extraocular muscle surgery (to correct the resultant large angle torsion), in a prospective study. METHODS: A custom sli ... Full text Link to item Cite

Optical coherence tomography reader agreement in neovascular age-related macular degeneration.

Journal article Am J Ophthalmol · July 2007 Featured Work PURPOSE: To determine the interreader and intrareader agreement at the Optical Coherence Tomography (OCT) Reading Center at Duke for images produced for an interventional neovascular age-related macular degeneration (AMD) clinical trial. DESIGN: Retrospect ... Full text Link to item Cite

Fixation switch and diplopia after full macular translocation surgery.

Journal article J AAPOS · April 2007 Featured Work PURPOSE: We sought to identify and evaluate treatment of patients who switched fixation to the poorer-seeing eye and complained of persistent diplopia 6 to 12 months after full macular translocation surgery (MT360) and extraocular muscle surgery. METHODS: ... Full text Link to item Cite

Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19.

Journal article Ophthalmic Epidemiol · 2007 PURPOSE: To evaluate responsiveness of the National Eye Institute Visual Function Questionnaire (NEI-VFQ) to changes in visual acuity and to provide estimates of minimum clinically meaningful changes in NEI-VFQ scores. METHODS: Data were combined from thre ... Full text Link to item Cite

Complement factor H increases risk for atrophic age-related macular degeneration.

Journal article Ophthalmology · September 2006 Featured Work OBJECTIVE: To determine if the complement factor H gene (CFH) determines risk for development of geographic atrophy (GA). DESIGN: Retrospective case-control study. PARTICIPANTS AND CONTROLS: The independent case-control data set contained 647 age-related m ... Full text Link to item Cite

Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials (vol 141, pg 93, 2006)

Journal article AMERICAN JOURNAL OF OPHTHALMOLOGY · August 2006 Link to item Cite

Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report no. 15

Journal article OPHTHALMOLOGY · February 1, 2006 Full text Link to item Cite

Comparison of 2D reconstructions of surgically excised subfoveal choroidal neovascularization with fluorescein angiographic features: SST report No. 15.

Journal article Ophthalmology · February 2006 OBJECTIVES: To compare topographic features of surgically excised subfoveal choroidal neovascularization with preoperative and postoperative fluorescein angiographic features from Submacular Surgery Trials (SST) patients, and to compare histological and an ... Full text Link to item Cite

Precision targeting with a tracking adaptive optics scanning laser ophthalmoscope

Journal article Optics Infobase Conference Papers · January 1, 2006 We have designed and built a novel imaging system combining scanning laser ophthalmoscopy, active image stabilization, and adaptive optics for precise imaging and targeting of retinal structures. System capabilities are demonstrated in humans and animals. ... Cite

Macular degeneration: the latest in current surgical management.

Journal article Retina · 2006 Featured Work Full text Link to item Cite

Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16.

Journal article Am J Ophthalmol · January 2006 Featured Work PURPOSE: To compare the fundus photographic and fluorescein angiographic features with the histologic findings in eyes from patients enrolled in the Submacular Surgery Trials (SST). DESIGN: Clinical trials with clinicopathologic correlation. METHODS: Eyes ... Full text Link to item Cite

Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management.

Journal article Ophthalmology · January 2006 Featured Work PURPOSE: To report a new extraocular muscle surgery procedure for large-angle extorsion, and clinical management of subjective tilt and diplopia after full macular translocation (MT360). DESIGN: Consecutive retrospective case series. PARTICIPANTS: Seven pa ... Full text Link to item Cite

A method to free retina and vitreous from intraoperative incarceration in the sclerotomy.

Journal article Retina · 2006 Featured Work Full text Link to item Cite

Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

Journal article Proc Natl Acad Sci U S A · August 16, 2005 Featured Work Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the Western world. We describe here a murine model that combines three known ... Full text Link to item Cite

Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.

Journal article Arch Ophthalmol · July 2005 Featured Work OBJECTIVE: To assess the prevalence of recurrence of macular geographic atrophy (GA) of the retinal pigment epithelium (RPE) after macular translocation with 360 degrees retinectomy (MT360) in one institution. METHODS: A retrospective review of all cases o ... Full text Link to item Cite

Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7.

Journal article Arch Ophthalmol · July 2005 Featured Work OBJECTIVES: To identify the histologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions from patients enrolled in the Submacular Surgery Trials and to compare them with clinical data. METHODS: Surgically excised su ... Full text Link to item Cite

Vision-related quality of life in patients with bilateral severe age-related macular degeneration.

Journal article Ophthalmology · January 2005 Featured Work PURPOSE: To determine the quality of life (QOL) of patients with bilateral severe age-related macular degeneration (AMD) before macular translocation with 360 degrees peripheral retinectomy. DESIGN: Prospective, consecutive, noncomparative case series. MET ... Full text Link to item Cite

Impact of fluorescein angiographic characteristics of macular lesions on outcomes after macular translocation 360 degree surgery in eyes with age-related macular degeneration.

Journal article Retina · 2005 Featured Work PURPOSE: To evaluate the relationship between preoperative lesion size and composition and visual outcomes at 1 year after macular translocation surgery with 360 degree peripheral retinectomy (MT360) for neovascular age-related macular degeneration (AMD). ... Full text Link to item Cite

Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration.

Journal article Ophthalmology · January 2005 Featured Work PURPOSE: To determine patients' quality of life (QOL) after macular translocation with 360 degrees peripheral retinectomy (MT360) for age-related macular degeneration. DESIGN: Prospective, interventional, consecutive, noncomparative case series. METHODS: A ... Full text Link to item Cite

Surgical removal vs observation for subfoveal choroidal neovascularization, either associated with the ocular histoplasmosis syndrome or idiopathic: I. Ophthalmic findings from a randomized clinical trial: Submacular Surgery Trials (SST) Group H Trial: SST Report No. 9.

Journal article Arch Ophthalmol · November 2004 Featured Work OBJECTIVE: To present visual acuity findings and related outcomes from eyes of patients enrolled in a randomized trial conducted by the Submacular Surgery Trials (SST) Research Group (SST Group H Trial) to compare surgical removal vs observation of subfove ... Full text Link to item Cite

Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration.

Journal article Ophthalmology · September 2004 Featured Work OBJECTIVE: To measure the change in vision and visual outcomes at 12 months after macular translocation with 360 degrees retinectomy (MT360) and silicone oil tamponade in patients with bilateral vision loss resulting from subfoveal choroidal neovascular me ... Full text Link to item Cite

Radial optic neurotomy in the porcine eye without retinal vein occlusion.

Journal article Arch Ophthalmol · August 2004 Featured Work OBJECTIVE: To demonstrate the histopathologic changes in the porcine eye without retinal vein occlusion after radial optic neurotomy (RON). METHODS: A RON was performed in 14 normal eyes of 12 Yorkshire Cross pigs. One radial stab incision at the edge of t ... Full text Link to item Cite

Health- and vision-related quality of life among patients with choroidal neovascularization secondary to age-related macular degeneration at enrollment in randomized trials of submacular surgery: SST report no. 4.

Journal article Am J Ophthalmol · July 2004 PURPOSE: To describe the effect of subfoveal choroidal neovascularization (CNV) from age-related macular degeneration (AMD) on health-related quality of life (HRQOL) of patients at enrollment in two randomized clinical trials; to examine the relation of vi ... Full text Link to item Cite

Improvement in near visual function after macular translocation surgery with 360-degree peripheral retinectomy.

Journal article Graefes Arch Clin Exp Ophthalmol · July 2004 Featured Work BACKGROUND: Information is limited on how specific near-vision skills are impacted by therapies such as macular translocation surgery with 360-degree retinectomy (MT360) for age-related macular degeneration (AMD). METHODS: Standardized tests of near vision ... Full text Link to item Cite

Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size.

Journal article J Biomed Opt · 2004 Featured Work We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in e ... Full text Link to item Cite

Student USMLE step 1 preparation and performance.

Journal article Adv Health Sci Educ Theory Pract · 2004 OBJECTIVES: Many medical students take commercial preparation courses to prepare for the USMLE Step 1. This investigation examined the relationships among Step 1 performance, preparation method, and academic achievement in medical school. METHOD: A survey ... Full text Link to item Cite

Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularization.

Journal article Am J Ophthalmol · November 2003 Featured Work PURPOSE: To determine the visual outcomes of eyes that underwent macular translocation surgery with 360 degrees peripheral retinectomy and silicone oil tamponade (MTS360) following ocular photodynamic therapy (OPT) with verteporfin for subfoveal choroidal ... Full text Link to item Cite

Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study.

Journal article Am J Ophthalmol · October 2003 Featured Work PURPOSE: To report the results of a prospective clinical series to evaluate the management of both torsion and diplopia in a large group of patients after full macular translocation (FMT) and extraocular muscle surgery. DESIGN: Prospective interventional c ... Full text Link to item Cite

Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rod.

Journal article J AAPOS · April 2003 Featured Work PURPOSE: To compare two methods of measuring ocular torsion (the subjective Maddox rod [MR] test versus the objective disc-fovea angle [DFA] test) after macular translocation surgery. METHODS: Ocular torsion was measured on consecutive patients after macul ... Full text Link to item Cite

Responsiveness of the National Eye Institute Visual Function Questionnaire to changes in visual acuity: findings in patients with subfoveal choroidal neovascularization--SST Report No. 1.

Journal article Arch Ophthalmol · April 2003 BACKGROUND: The National Eye Institute Visual Function Questionnaire (NEI-VFQ) measures vision-targeted quality of life, but it is unclear whether it is sensitive to changes within individuals over time. OBJECTIVE: To determine the responsiveness of the NE ... Full text Link to item Cite

Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.

Journal article Arch Ophthalmol · January 2003 Featured Work Full text Link to item Cite

RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis.

Journal article Curr Eye Res · December 2002 Featured Work PURPOSE: To evaluate a new concept in pharmacological vitreolysis by studying the efficacy of intravitreal RGD peptide-assisted vitrectomy in facilitating the separation of the posterior cortical vitreous from the retinal surface in an animal model. METHOD ... Full text Link to item Cite

Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

Journal article Invest Ophthalmol Vis Sci · November 2002 PURPOSE: To evaluate the effects of subretinal and intravitreal delivery of INS37217, a P2Y(2) receptor agonist, on subretinal fluid reabsorption in experimentally induced retinal detachments in rabbits, and to characterize the effects of INS37217 on elect ... Link to item Cite

Development and characterization of a vitreous mimicking material for radiation force imaging.

Journal article IEEE Trans Ultrason Ferroelectr Freq Control · November 2002 Featured Work In many medical ultrasound applications tissue-mimicking phantoms are of fundamental importance for the performance of controlled experiments. Traditionally, such phantoms have been constructed using gelatin and agar gels. Although the use of these materia ... Full text Link to item Cite

Visual outcomes following macular translocation with 360-degree peripheral retinectomy.

Journal article Arch Ophthalmol · October 2002 Featured Work OBJECTIVE: To evaluate visual outcomes following macular translocation with 360 degrees peripheral retinectomy in patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration. METHODS: In a prospective study, 15 consec ... Full text Link to item Cite

Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration.

Journal article Arch Ophthalmol · June 2002 Featured Work OBJECTIVE: To determine the prevalence and visual significance of cystoid macular edema (CME) in eyes with subfoveal neovascular age-related macular degeneration using optical coherence tomography (OCT). MATERIALS AND METHODS: The medical records of 61 con ... Full text Link to item Cite

Strabismus surgery for large-angle cyclotorsion after macular translocation surgery.

Journal article J AAPOS · June 2002 Featured Work PURPOSE: We report the results of a new strabismus surgical procedure to address the large-angle cyclotorsion induced by macular translocation surgery for severe age-related macular degeneration. METHODS: The strabismus surgery described is a modification ... Full text Link to item Cite

Thresholds for retinal injury from multiple near-infrared ultrashort laser pulses.

Journal article Health Phys · June 2002 Featured Work Multiple-pulse lasers are routinely used in the laboratory for research, manufacturing, medical procedures, and in military applications. In order to provide a safe work environment for personnel using these lasers, safety standards have been established a ... Full text Link to item Cite

Age-related changes in vitreous mobility as measured by video B scan ultrasound.

Journal article Exp Eye Res · February 2002 Featured Work Many vitreoretinal disorders increase in incidence with age. The vitreous is known to liquefy and separate from the retina in aging patients. Liquefaction and partial vitreous separation alter the biomechanics of the vitreous and change the tractional forc ... Full text Link to item Cite

A comparative study of retinal effects from continuous wave and femtosecond mode-locked lasers.

Journal article Lasers Surg Med · 2002 Featured Work BACKGROUND AND OBJECTIVES: In order to provide a direct comparison of the effects of mode-locked systems to those with continuous-wave (CW) or nonpulsed output, we have performed an experiment with lasers possessing otherwise identical output characteristi ... Full text Link to item Cite

Macular translocation with radial scleral ouffolding: experimental studies and initial human results.

Journal article Graefes Arch Clin Exp Ophthalmol · November 2001 Featured Work PURPOSE: Different techniques have been proposed for translocating the macula in patients with subfoveal neovascularization secondary to age-related macular degeneration. A new approach utilizing radial outfolding of the sclera was investigated. MATERIALS ... Full text Link to item Cite

Induced corneal astigmatism after macular translocation surgery with scleral infolding.

Journal article Ophthalmology · July 2001 Featured Work OBJECTIVE: To document the corneal astigmatism that occurs with macular translocation after scleral infolding surgery. DESIGN: Retrospective case series of a nonrandomized clinical trial. PARTICIPANTS: Eight consecutive age-related macular degeneration pat ... Full text Link to item Cite

Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature.

Journal article Graefes Arch Clin Exp Ophthalmol · June 2001 Featured Work BACKGROUND: The development of tears of the retinal pigment epithelium (RPE) has classically been described with or without choroidal neovascularization (CNV) or after laser treatment. Tangential shear forces within the RPE or CNV are usually considered to ... Full text Link to item Cite

Macular translocation: unifying concepts, terminology, and classification.

Journal article Am J Ophthalmol · February 2001 Featured Work PURPOSE: To describe some unifying concepts, terminology, and classification of macular translocation so as to facilitate communication within the scientific community. METHODS: A panel of ophthalmologists with expertise in macular translocation reviewed a ... Full text Link to item Cite

Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration.

Journal article Am J Ophthalmol · February 2001 Featured Work PURPOSE: To evaluate a new procedure for displacement of large, thick submacular hemorrhage in patients with age-related macular degeneration. METHODS: Retrospective review of 11 eyes of 11 patients with age-related macular degeneration and thick submacula ... Full text Link to item Cite

In-vivo response to free electron laser incision of the rabbit cornea.

Journal article Lasers Surg Med · 2001 Featured Work BACKGROUND AND OBJECTIVE: We analyzed the in vivo ocular response to corneal incisions made by Medical Free Electron Laser (MFEL) as a function of scan rate and incision depth. Additionally, we compared biomicroscopy, optical coherence tomography (OCT), an ... Full text Link to item Cite

Successful macular translocation with temporary scleral infolding using absorbable sture.

Journal article Retina · 2001 Featured Work PURPOSE: To describe successful macular translocation with temporary scleral infolding in a series of patients with small subfoveal choroidal neovascularization due to age-related macular degeneration or ocular histoplasmosis syndrome. METHODS: Ten eyes of ... Full text Link to item Cite

Macular translocation with 360-degree peripheral retinectomy impact of technique and surgical experience on visual outcomes.

Journal article Retina · 2001 Featured Work PURPOSE: To evaluate the impact of technique and surgical experience on complications and outcomes of macular translocation surgery with 360-degree peripheral retinectomy (MTS360). METHODS: Twenty-six consecutive patients underwent MTS360 in a prospective ... Full text Link to item Cite

Visible lesion threshold dependence on retinal spot size for femtosecond laser pulses

Journal article Journal of Laser Applications · January 1, 2001 National laser safety standards have only recently been specified for laser pulse widths below 1 ns, with the publication of the ANSI Z136.1-2000 American National Standard for Safe Use of Lasers. A number of in vivo retinal injury studies using ultrashort ... Full text Cite

Submacular surgery trials randomized pilot trial of laser photocoagulation versus surgery for recurrent choroidal neovascularization secondary to age-related macular degeneration: I. Ophthalmic outcomes submacular surgery trials pilot study report number 1.

Journal article Am J Ophthalmol · October 2000 PURPOSE: To report complications and changes in vision during 2 years of follow-up of patients with age-related macular degeneration assigned randomly to surgical removal or to laser photocoagulation of subfoveal recurrent neovascular lesions in a pilot tr ... Full text Link to item Cite

Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses.

Journal article J Biomed Opt · July 2000 Featured Work Single 130 fs laser pulses in the near-IR (800 nm) were used to create ophthalmoscopically viewed minimum visible lesions (MVLs) within the macular and paramacular regions in rhesus monkey eyes. MVL thresholds at 1 and 24 h are reported as the 50% probabil ... Full text Link to item Cite

Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery.

Journal article J AAPOS · April 2000 Featured Work PURPOSE: The purpose of this study was to evaluate the effects of oblique muscle surgery on the large-angle incyclotorsion resulting from macular translocation surgery for severe age-related macular degeneration. METHODS: Patients undergoing macular transl ... Full text Link to item Cite

Features of macular hole closure in the early postoperative period using optical coherence tomography.

Journal article Retina · 2000 Featured Work PURPOSE: Studying the retina in the early postoperative period after macular hole surgery is difficult because of the limitation of imaging of the fundus through a gas tamponade. Silicone oil was shown recently to be an effective alternative to gas for mac ... Link to item Cite

Electron immunocytochemical analysis of posterior hyaloid associated with diabetic macular edema.

Journal article Retina · 2000 Featured Work BACKGROUND: Tangential traction in the macula from a thickened posterior hyaloid of the vitreous has been implicated as a cause of diffuse diabetic macular edema. Vitrectomy with peeling of the posterior hyaloid has been shown to reduce retinovascular leak ... Full text Link to item Cite

Diagnosis of vitreoretinal adhesions in macular disease with optical coherence tomography.

Journal article Retina · 2000 Featured Work PURPOSE: To compare the relative incidence of vitreoretinal adhesions associated with partial vitreous separation within the macula diagnosed with optical coherence tomography (OCT) with that of those diagnosed with biomicroscopy. METHODS: The authors obta ... Link to item Cite

Thresholds for visible lesions in the primate eye produced by ultrashort near-infrared laser pulses.

Journal article Invest Ophthalmol Vis Sci · September 1999 Featured Work PURPOSE: To evaluate the effects of near-infrared (near-IR) ultrashort laser pulses on the retinas of rhesus monkey eyes and to perform threshold measurements for minimum visible lesions (MVLs) at pulse widths ranging from nanoseconds to femtoseconds. METH ... Link to item Cite

Ultrashort laser pulse bioeffects and safety.

Journal article J Laser Appl · February 1999 Featured Work Recent studies of retinal damage due to ultrashort laser pulses have shown that less energy is required for retinal damage for pulses shorter than 1 ns than that for longer pulses. It has also been shown that more energy is required for near-infrared (NIR) ... Full text Link to item Cite

Diagnostic and therapeutic challenges.

Journal article Retina · 1999 Full text Link to item Cite

Thrombolytic therapy for acute MI in diabetics with retinopathy

Journal article Cardiology Review · January 1, 1999 Ocular hemorrhage after thrombolytic therapy for acute MI is rare, yet diabetic retinopathy has been considered a contraindication to thrombolysis without clear evidence of an increased risk for ocular hemorrhage. We evaluated 41,021 GUSTO-I trial patients ... Cite

Matrix metalloproteinases and their inhibitors in human vitreous.

Journal article Invest Ophthalmol Vis Sci · June 1998 Featured Work PURPOSE: To conduct zymographic analysis to study the matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in vitreous samples of patients undergoing pars plana vitrectomy as part of the treatment of vitreoretinal disease. ME ... Link to item Cite

Transplantation of feline islets of Langerhans in the subretinal space of cat eyes.

Journal article Transplant Proc · March 1998 Featured Work Full text Link to item Cite

A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy.

Journal article Arch Ophthalmol · November 1997 Featured Work OBJECTIVE: To compare the cross-sectional images of primate retinal morphology obtained by optical coherence tomography (OCT) with light microscopy to determine the retinal components represented in OCT images. METHODS: Laser pulses were delivered to the r ... Full text Link to item Cite

Pathology of macular lesions from subnanosecond pulses of visible laser energy.

Journal article Invest Ophthalmol Vis Sci · October 1997 Featured Work PURPOSE: To demonstrate how current theories regarding ultrashort laser pulse effects may apply to ocular tissue, a prospective clinicopathologic study of macular lesions from ultrashort laser pulses compared the pathologic effects with the clinical and fl ... Link to item Cite

Recombinant hirudin prevents postoperative fibrin formation after experimental cataract surgery.

Journal article Ophthalmology · March 1997 Featured Work PURPOSE: The authors studied the effect of a direct acting antithrombin agent, desulfatohirudin variant 1 (Revasc, Ciba-Geigy, Ltd., Basel, Switzerland), on postoperative fibrin formation after cataract surgery in rabbits. METHODS: Phacoemulsification was ... Full text Link to item Cite

Intraocular laser surgical probe for membrane disruption by laser-induced breakdown.

Journal article Appl Opt · March 1, 1997 Featured Work A fiber probe has been designed as a surgical aid to cut intraocular membranes with laser-induced breakdown as the mechanism. The design of the intraocular laser surgical probe is discussed. A preliminary retinal damage distance has been calculated with br ... Full text Link to item Cite

Argon laser retinal lesions evaluated in vivo by optical coherence tomography.

Journal article Am J Ophthalmol · February 1997 Featured Work PURPOSE: To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential optical coherence tomography with histopathologic sectioning. METHODS: Argon laser lesions were created in the retinas of M ... Full text Link to item Cite

Intraocular injection of recombinant hirudin to prevent experimental postoperative fibrin.

Journal article Retina · 1997 Featured Work PURPOSE: To test the efficacy of a single intraocular injection of various doses of recombinant desulphatohirudin variant 1 (Revasc) in a rabbit model after lensectomy-vitrectomy surgery. METHODS: Standard fragmatome lensectomies and core vitrectomies were ... Full text Link to item Cite

Retinal damage and laser-induced breakdown produced by ultrashort-pulse lasers.

Journal article Graefes Arch Clin Exp Ophthalmol · August 1996 Featured Work BACKGROUND: In vivo retinal injury studies using ultra-short-pulse lasers at visible wavelengths for both rabbit and primate eyes have shown that the degree of injury to the retina is not proportional to the pulse energy, especially at suprathreshold level ... Full text Link to item Cite

Recombinant hirudin for prevention of experimental postoperative intraocular fibrin.

Journal article Am J Ophthalmol · May 1996 Featured Work PURPOSE: To determine the efficacy of a specific antithrombin agent (recombinant desulphatohirudin variant 1 [Revasc, Ciba-Geigy, Ltd., Basel, Switzerland]) administered in the infusion fluid to prevent early postoperative fibrin formation in a rabbit lens ... Full text Link to item Cite

Tissue plasminogen activator for preserving inferior peripheral iridectomy patency in eyes with silicone oil.

Journal article Ophthalmology · February 1996 Featured Work PURPOSE: An inferior peripheral iridectomy (IPI) was used to prevent forward migration of silicone oil in vitrectomized eyes; however, in approximately one third of eyes, the IPI closed spontaneously. Occlusion of the IPI by fibrin is believed to be an ear ... Full text Link to item Cite

Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats.

Journal article J Cereb Blood Flow Metab · September 1995 As part of the acute inflammatory response, neutrophils accumulate in the central nervous system after injury. Recently, a soluble human recombinant complement receptor (sCR1; BRL 55730; T Cell Sciences, Inc., Cambridge, MA, U.S.A.) has been developed that ... Full text Link to item Cite

Retinal effects of ultrashort laser pulses in the rabbit eye.

Journal article Invest Ophthalmol Vis Sci · August 1995 Featured Work PURPOSE: To evaluate the effects of ultrashort laser pulses from femtoseconds to nanoseconds on the retinas of live rabbit eyes and to determine the energy requirements for visible lesion development. METHODS: The retinal effects of laser exposures were ex ... Link to item Cite

Visible retinal lesions from ultrashort laser pulses in the primate eye.

Journal article Invest Ophthalmol Vis Sci · April 1995 Featured Work PURPOSE: To evaluate the effects of ultrashort laser pulses of visible wavelengths on the retinas of rhesus monkey eyes and to perform threshold measurements for minimum visible lesions (MVLs) at pulsewidths from nanoseconds to femtoseconds. METHODS: Singl ... Link to item Cite

Clinicopathologic correlation of spontaneous retinal pigment epithelial tears with choroidal neovascular membranes in age-related macular degeneration.

Journal article Ophthalmology · February 1995 Featured Work BACKGROUND: A correlation of the clinical and histopathologic features of age-related macular degeneration (AMD), complicated by choroidal neovascular membrane (CNVM) with spontaneous tears of retinal pigment epithelial (RPE) detachment, has not been repor ... Full text Link to item Cite

Nonlinear refraction in vitreous humor.

Journal article Opt Lett · November 1, 1993 Featured Work We extend the application of the z-scan technique to determine the nonlinear refractive index (n(2)) for human and rabbit vitreous humor, water, and physiological saline. In these measurements there were nonlinear contributions to the measured signal from ... Full text Link to item Cite

A glass micropipette holder for ophthalmic surgical procedures.

Journal article Am J Ophthalmol · October 15, 1993 Featured Work Full text Link to item Cite

Above-threshold multiphoton photoelectric effect of a gold surface

Journal article Optical Engineering · 1993 Full text Cite

A peptide sequence on carcinoembryonic antigen binds to a 80kD protein on Kupffer cells.

Journal article Biochem Biophys Res Commun · October 30, 1992 Clearance of carcinoembryonic antigen (CEA) from the circulation is by binding to Kupffer cells in the liver. We have shown that CEA binding to Kupffer cells occurs via a peptide sequence YPELPK representing amino acids 107-112 of the CEA sequence. This pe ... Full text Link to item Cite

Observation of multiple-harmonic radiation induced from a gold surface by picosecond neodymium-doped yttrium aluminum garnet laser pulses

Journal article Physical Review A · October 1, 1992 Full text Cite

Proposal for attosecond light pulse generation using laser induced multiple-harmonic conversion processes in rare gases

Journal article Physics Letters A · September 1992 Full text Cite

Carcinoembryonic antigen binding proteins on elicited peritoneal macrophages.

Journal article J Leukoc Biol · May 1992 Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperit ... Full text Link to item Cite

An experimental model of ectropion uveae and iris neovascularization in the cat.

Journal article Invest Ophthalmol Vis Sci · April 1992 Featured Work Neovascularization of the iris (NVI) is one of the most frequently studied intraocular vascular proliferations in animal models. Ectropion uveae has not been a consistent finding in these studies. In this study, a surgical model of ectropion uveae and iris ... Link to item Cite

Ultramicrosurgical removal of subretinal hemorrhage in cats.

Journal article Am J Ophthalmol · February 15, 1992 Featured Work Subretinal hemorrhages are associated with progressive degeneration of the outer retina and a corresponding poor visual prognosis. Mixed results have been reported in previous attempts to remove such subretinal hemorrhages. We developed an ultramicrosurgic ... Full text Link to item Cite

Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production.

Journal article Clin Exp Metastasis · January 1992 The relationship between cellular differentiation and carcinoembryonic antigen (CEA) production by human colorectal tumor cells and their ability to form hepatic metastases was studied. Eight human colon cancer cell lines were injected into athymic mice us ... Full text Link to item Cite

Treatment of retinopathy of prematurity with argon laser photocoagulation.

Journal article Arch Ophthalmol · January 1992 Featured Work Fifteen eyes of nine infants were treated for retinopathy of prematurity by confluent photocoagulation of the avascular retina using an argon laser indirect ophthalmoscope. All treated eyes presented at or beyond threshold of stage 3 retinopathy of prematu ... Full text Link to item Cite

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye.

Journal article Graefes Arch Clin Exp Ophthalmol · 1992 Featured Work The feasibility of gamma (gamma)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit gamma-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that int ... Full text Link to item Cite

Evaluation of a commercial recombinant tissue-type plasminogen activator preparation in the subretinal space of the cat.

Journal article Arch Ophthalmol · December 1991 Featured Work To explore the feasibility of using human recombinant tissue-type plasminogen activator in the management of subretinal hemorrhage, we examined the toxic effects of a commercial preparation of human recombinant tissue-type plasminogen activator in the subr ... Full text Link to item Cite

Laser-induced electron emission from an Au surface irradiated by single picosecond pulses at ?=2.94 ?m. The intermediate region between multiphoton and tunneling effects

Journal article Applied Physics B Photophysics and Laser Chemistry · October 1991 Full text Cite

Fibrin directs early retinal damage after experimental subretinal hemorrhage.

Journal article Arch Ophthalmol · May 1991 Featured Work Subretinal blood within the macula may cause visual loss in a number of macular diseases. The clinical and histopathologic effects of experimental subretinal hemorrhage were evaluated in the cat. Subretinal hemorrhages were produced by creating a focal neu ... Full text Link to item Cite

A carcinoembryonic antigen (CEA) binding protein from ascites influences CEA uptake by macrophages.

Journal article Biochem Biophys Res Commun · September 14, 1990 A variant of CEA which is less readily endocytosed by macrophages has been isolated from malignant ascites. In vivo, CEA is cleared more slowly by the liver (t1/2 = 15.1 minutes) than CEAs isolated from hepatic metastases (t1/2 = 3.1 minutes). In vitro, ra ... Full text Link to item Cite

Carcinoembryonic antigen binding to Kupffer cells is via a peptide located at the junction of the N-terminal and first loop domains.

Journal article Biochem Biophys Res Commun · July 16, 1990 A 11kD glycopeptide has been isolated by pepsin digestion of carcinoembryonic antigen (CEA) that is rapidly endocytosed by isolated rat Kupffer cells and lung alveolar macrophages. Uptake of this glycopeptide by the isolated cells can be inhibited by exces ... Full text Link to item Cite

Energy spectrum of photoelectrons produced by picosecond laser-induced surface multiphoton photoeffect.

Journal article Phys Rev A · April 1, 1990 Full text Link to item Cite

Laser induced electron emission from gold surface irradiated by picosecond pulses at ?=2.9 ?m

Journal article Applied Physics B Photophysics and Laser Chemistry · June 1989 Full text Cite

Receptor-mediated endocytosis of carcinoembryonic antigen by rat alveolar macrophages in vitro.

Journal article J Leukoc Biol · April 1989 Uptake of carcinoembryonic antigen (CEA) by isolated rat alveolar cells was time, temperature, and concentration dependent (Kuptake = 2.4 x 10(-7) M). Pretreatment of the alveolar cells with colchicine inhibited internalization of CEA. Uptake of 125I-label ... Full text Link to item Cite

High current, small divergence electron beams produced by laser-induced surface photoelectric effect

Journal article Journal of Applied Physics · April 1, 1989 The potential application of the laser induced linear surface photoelectric effect for high current and small divergence electron beam formation is examined. The temporal evolution of the current pulses and the angular distribution of the photoelec ... Full text Cite

Hepatic clearance and metabolism in the rat of a human breast cancer associated glycoprotein (GCDFP-15).

Journal article Breast Cancer Res Treat · October 1988 Gross Cystic Disease Fluid Protein (GCDFP-15) is a 60,000 dalton glycoprotein isolated from human breast cyst fluid, composed of four 15,000 dalton monomers. Carbohydrate analysis indicates that each monomer has a single carbohydrate chain of the complex t ... Full text Link to item Cite

Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells.

Journal article Cancer Res · January 1985 In vivo, carcinoembryonic antigen (CEA) is removed from the circulation by the liver Kupffer cells. Immunologically identifiable CEA is transferred from these macrophages to the hepatocytes, where degradation is completed. Circulatory clearance of CEA is s ... Link to item Cite

A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat.

Journal article Biochem J · May 15, 1982 Native human carcinoembryonic antigen is rapidly removed from the circulation by the rat liver Kupffer cell after intravenous injection. The molecule is subsequently transferred to the hepatocyte in an immunologically identifiable form. Carcinoembryonic an ... Full text Link to item Cite