Scholars@Duke

• Background
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  Education, Training, & Certifications

  • M.D., University of Texas, Medical Branch at Galveston 1995
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  Duke Appointment History

  • Associate Professor in Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 2012 - 2020
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences 2012 - 2020
  • Assistant Professor in Community and Family Medicine, Family Medicine and Community Health, Physician Assistant Program, Family Medicine and Community Health 2009 - 2013
  • Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences 2008 - 2012
  • Clinical Associate in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology, Psychiatry & Behavioral Sciences 2006 - 2008
• Recognition
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  In the News

  • NOV 7, 2013

    News 14

    Duke University unveils airport safety research
• Research
• 

  Selected Grants

  • DS5565-A-E309 - A Randomized Double-Blind, Placebo-and active-Controlled Study of DS-5565 in Subjects with Pain Associated With Fibromyalgia awarded by Daiichi Sankyo Co Ltd 2015 - 2019
  • DS-5565-E312: An Open-Label Extension Study of DS-5565 for 52 weeks in Pain Associated with Fibromyalgia awarded by Daiichi Sankyo Co Ltd 2015 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lin, Katherine A., Kingshuk Roy Choudhury, Bharath G. Rathakrishnan, David M. Marks, Jeffrey R. Petrella, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Marked gender differences in progression of mild cognitive impairment over 8 years.” Alzheimers Dement (N Y) 1, no. 2 (September 1, 2015): 103–10. https://doi.org/10.1016/j.trci.2015.07.001.
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    • Marks, David M., and Amy Newhouse. “Durability of Benefit From Repeated Intravenous Lidocaine Infusions in Fibromyalgia Patients: A Case Series and Literature Review.” Prim Care Companion Cns Disord 17, no. 5 (2015). https://doi.org/10.4088/PCC.15br01804.
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    • Marks, David M., Chi-Un Pae, and Ashwin A. Patkar. “A double-blind, placebo-controlled, parallel-group pilot study of milnacipran for chronic radicular pain (sciatica) associated with lumbosacral disc disease.” Prim Care Companion Cns Disord 16, no. 4 (2014). https://doi.org/10.4088/PCC.14m01658.
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    • Kim, Jeong Lan, Shilpa Rele, David M. Marks, Prakash S. Masand, Pallavi Yerramsetty, Robert A. Millet, Richard S. Keefe, and Ashwin A. Patkar. “Effects of milnacipran on neurocognition, pain, and fatigue in fibromyalgia: a 13-week, randomized, placebo-controlled, crossover trial.” Prim Care Companion Cns Disord 15, no. 6 (2013). https://doi.org/10.4088/PCC.13m01555.
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    • Marks, David M., and Michael P. Bolognesi. “Open-label milnacipran for patients with persistent knee pain 1 year or longer after total knee arthroplasty: a pilot study.” Prim Care Companion Cns Disord 15, no. 4 (2013). https://doi.org/10.4088/PCC.12m01496.
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    • Marks, David M., Jonathan S. Abramowitz, and Glen I. Spielmans. “Concerns about data reporting and interpretation in "Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial".” J Psychiatr Res 46, no. 5 (May 2012): 692–93. https://doi.org/10.1016/j.jpsychires.2012.02.002.
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    • Marks, D. M. “Amitifadine hydrochloride: Triple reuptake inhibitor treatment of depression.” Drugs of the Future 37, no. 4 (April 1, 2012): 241–46. https://doi.org/10.1358/dof.2012.37.4.1782933.
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    • Marks, D. M. “Amitifadine hydrochloride: Triple reuptake inhibitor treatment of depression.” Drugs of the Future 37, no. 4 (January 1, 2012): 241–46. https://doi.org/10.1358/dof.2012.037.04.1782933.
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    • Hardy, T. A., R. R. Henry, T. D. Forrester, L. A. Kryzhanovskaya, G. M. Campbell, D. M. Marks, and S. Mudaliar. “Impact of olanzapine or risperidone treatment on insulin sensitivity in schizophrenia or schizoaffective disorder.” Diabetes Obes Metab 13, no. 8 (August 2011): 726–35. https://doi.org/10.1111/j.1463-1326.2011.01398.x.
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    • Marks, David M., Manan J. Shah, Ashwin A. Patkar, Prakash S. Masand, Geun-Young Park, and Chi-Un Pae. “Serotonin-norepinephrine reuptake inhibitors for pain control: premise and promise.” Curr Neuropharmacol 7, no. 4 (December 2009): 331–36. https://doi.org/10.2174/157015909790031201.
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    • Pae, Chi-Un, Haresh Tharwani, David M. Marks, Prakash S. Masand, and Ashwin A. Patkar. “Atypical depression: a comprehensive review.” Cns Drugs 23, no. 12 (December 2009): 1023–37. https://doi.org/10.2165/11310990-000000000-00000.
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    • Pae, Chi-Un, David M. Marks, Manan Shah, Changsu Han, Byung-Joo Ham, Ashwin A. Patkar, and Prakash S. Masand. “Milnacipran: beyond a role of antidepressant.” Clin Neuropharmacol 32, no. 6 (November 2009): 355–63. https://doi.org/10.1097/WNF.0b013e3181ac155b.
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    • Pae, Chi-Un, Prakash S. Masand, David M. Marks, Stan Krulewicz, Kathleen Peindl, Paolo Mannelli, and Ashwin A. Patkar. “History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia.” Prog Neuropsychopharmacol Biol Psychiatry 33, no. 6 (August 31, 2009): 996–1002. https://doi.org/10.1016/j.pnpbp.2009.05.005.
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    • Pae, Chi-Un, David M. Marks, Ashwin A. Patkar, Prakash S. Masand, Patrick Luyten, and Alessandro Serretti. “Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants.” Expert Opin Pharmacother 10, no. 10 (July 2009): 1561–70. https://doi.org/10.1517/14656560902988510.
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    • Marks, David M., Ashwin A. Patkar, Prakash S. Masand, and Chi-Un Pae. “Does pregabalin have neuropsychotropic effects?: a short perspective.” Psychiatry Investig 6, no. 2 (June 2009): 55–58. https://doi.org/10.4306/pi.2009.6.2.55.
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    • Marks, David M., Matthew J. Conner, and Chi-Un Pae. “Safety and antipsychotic efficacy of "forced" intramuscular olanzapine over five days: a case report.” Prog Neuropsychopharmacol Biol Psychiatry 33, no. 2 (March 17, 2009): 386–87. https://doi.org/10.1016/j.pnpbp.2008.12.022.
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    • Han, Changsu, Kyung-phil Kwak, David M. Marks, Chi-Un Pae, Li-Tzy Wu, Kamal S. Bhatia, Prakash S. Masand, and Ashwin A. Patkar. “The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatry.” Contemp Clin Trials 30, no. 2 (March 2009): 116–22. https://doi.org/10.1016/j.cct.2008.11.004.
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    • Marks, David M., Thanaseelan J, and Chi-Un Pae. “Innovations in clinical research design and conduct in psychiatry: shifting to pragmatic approaches.” Psychiatry Investig 6, no. 1 (March 2009): 1–6. https://doi.org/10.4306/pi.2009.6.1.1.
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    • Pae, Chi-Un, David M. Marks, Prakash S. Masand, Kathleen Peindl, Christa Hooper-Wood, Changsu Han, Paolo Mannelli, Patrick Ciccone, and Ashwin A. Patkar. “Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial.” Clin Neuropharmacol 32, no. 2 (March 2009): 85–88. https://doi.org/10.1097/WNF.0b013e31817e559b.
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    • Pae, Chi-Un, Laura Mandelli, Tae-Suk Kim, Changsu Han, Prakash S. Masand, David M. Marks, Ashwin A. Patkar, David C. Steffens, Diana De Ronchi, and Alessandro Serretti. “Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects.” Biomed Pharmacother 63, no. 3 (March 2009): 228–35. https://doi.org/10.1016/j.biopha.2008.03.010.
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    • Pae, Chi-Un, David C. Marks, Changsu Han, Ashwin A. Patkar, and Prakash S. Masand. “Duloxetine: an emerging evidence for fibromyalgia.” Biomed Pharmacother 63, no. 1 (January 2009): 69–71. https://doi.org/10.1016/j.biopha.2008.03.011.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, Prakash S. Masand, and Ashwin A. Patkar. “Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: an open label pilot study.” Int Clin Psychopharmacol 24, no. 1 (January 2009): 29–33. https://doi.org/10.1097/YIC.0b013e32831feea9.
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    • Pae, Chi-Un, Min-Hyeon Park, David M. Marks, Changsu Han, Ashwin A. Patkar, and Prakash S. Masand. “Desvenlafaxine, a serotonin-norepinephrine uptake inhibitor for major depressive disorder, neuropathic pain and the vasomotor symptoms associated with menopause.” Curr Opin Investig Drugs 10, no. 1 (January 2009): 75–90.
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    • Pae, Chi-Un, Prakash S. Masand, David M. Marks, Stan Krulewicz, Changsu Han, Kathleen Peindl, Paolo Mannelli, and Ashwin A. Patkar. “History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.” World J Biol Psychiatry 10, no. 4 Pt 2 (2009): 435–41. https://doi.org/10.1080/15622970902789155.
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    • Marks, David M., Chi-Un Pae, and Ashwin A. Patkar. “Triple reuptake inhibitors: the next generation of antidepressants.” Curr Neuropharmacol 6, no. 4 (December 2008): 338–43. https://doi.org/10.2174/157015908787386078.
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    • Marks, David M., Min-Hyeon Park, Byung-Joo Ham, Changsu Han, Ashwin A. Patkar, Prakash S. Masand, and Chi-Un Pae. “Paroxetine: safety and tolerability issues.” Expert Opin Drug Saf 7, no. 6 (November 2008): 783–94. https://doi.org/10.1517/14740330802423168.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, Ashwin A. Patkar, and David Steffens. “Does neurotropin-3 have a therapeutic implication in major depression?” Int J Neurosci 118, no. 11 (November 2008): 1515–22. https://doi.org/10.1080/00207450802174589.
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    • Marks, David M., Chi-Un Pae, and Ashwin A. Patkar. “Triple reuptake inhibitors: a premise and promise.” Psychiatry Investig 5, no. 3 (September 2008): 142–47. https://doi.org/10.4306/pi.2008.5.3.142.
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    • Marks, David M., Chi-Un Pae, and Ashwin A. Patkar. “Potential role of pregabalin in the treatment of lithium-induced tremor: a case report.” Int J Neuropsychopharmacol 11, no. 6 (September 2008): 879–81. https://doi.org/10.1017/S146114570800878X.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, Ashwin A. Patkar, and Prakash Masand. “Delirium: underrecognized and undertreated.” Curr Treat Options Neurol 10, no. 5 (September 2008): 386–95. https://doi.org/10.1007/s11940-008-0041-x.
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    • Pae, Chi-Un, Patrick Luyten, David M. Marks, Changsu Han, Sung-Hwan Park, Ashwin A. Patkar, Prakash S. Masand, and Boudewijn Van Houdenhove. “The relationship between fibromyalgia and major depressive disorder: a comprehensive review.” Curr Med Res Opin 24, no. 8 (August 2008): 2359–71. https://doi.org/10.1185/03007990802288338.
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    • Han, Changsu, David M. Marks, Chi-Un Pae, Bun Hee Lee, Young-Hoop Ko, Prakash S. Masand, Ashwin A. Patkar, and In-Kwa Jung. “Paroxetine for patients with undifferentiated somatoform disorder: A prospective, open-label, 8-week pilot study.” Curr Ther Res Clin Exp 69, no. 3 (June 2008): 221–31. https://doi.org/10.1016/j.curtheres.2008.06.004.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, Ashwin A. Patkar, and Prakash Masand. “Delirium: where do we stand?” Curr Psychiatry Rep 10, no. 3 (June 2008): 240–48. https://doi.org/10.1007/s11920-008-0040-3.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, and Ashwin A. Patkar. “Does minocycline have antidepressant effect?” Biomed Pharmacother 62, no. 5 (June 2008): 308–11. https://doi.org/10.1016/j.biopha.2007.12.005.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, and Ashwin A. Patkar. “A case of transient hallucination with ropinirole augmentation antidepressant in a patient with treatment-resistant depression: Is there differential effect of ropinirole dose on developing psychotic symptom?” Prog Neuropsychopharmacol Biol Psychiatry 32, no. 4 (May 15, 2008): 1087–88. https://doi.org/10.1016/j.pnpbp.2008.02.011.
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    • Pae, Chi-Un, Changsu Han, David M. Marks, and Ashwin A. Patkar. “Comments on "Addition of lamotrigine to valproic acid: a successful outcome in a case of rapid-cycling bipolar affective disorder".” Prog Neuropsychopharmacol Biol Psychiatry 32, no. 2 (February 15, 2008): 595–96. https://doi.org/10.1016/j.pnpbp.2007.10.012.
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    • Marks, David M., Changsu Han, Stan Krulewicz, Chi-Un Pae, Kathleen Peindl, Ashwin A. Patkar, and Prakash S. Masand. “History of depressive and anxiety disorders and paroxetine response in patients with irritable bowel syndrome: post hoc analysis from a placebo-controlled study.” Prim Care Companion J Clin Psychiatry 10, no. 5 (2008): 368–75. https://doi.org/10.4088/pcc.v10n0504.
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    • Pae, Chi-Un, Prakash S. Masand, Kathleen Peindl, Paolo Mannelli, Changsu Han, David M. Marks, and Ashwin A. Patkar. “An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features.” Prim Care Companion J Clin Psychiatry 10, no. 3 (2008): 205–10. https://doi.org/10.4088/pcc.v10n0305.
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    • Vieta, E., J. R. Calabrese, J. M. Goikolea, S. Raines, W. Macfadden, and W. BOLDER Study Group. “Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study.” Bipolar Disord 9, no. 4 (June 2007): 413–25. https://doi.org/10.1111/j.1399-5618.2007.00479.x.
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    • Ziran, Bruce H., Ajay D. Wasan, David M. Marks, Steven A. Olson, and Michael W. Chapman. “Fluoroscopic imaging guides of the posterior pelvis pertaining to iliosacral screw placement.” J Trauma 62, no. 2 (February 2007): 347–56. https://doi.org/10.1097/01.ta.0000229789.18211.85.
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    • Ingels, Marianne, David Marks, and Richard F. Clark. “A survey of medical toxicology training in psychiatry residency programs.” Acad Psychiatry 27, no. 1 (2003): 50–53. https://doi.org/10.1176/appi.ap.27.1.50.
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