Scholars@Duke
David Needham

David Needham

Professor Emeritus in the Thomas Lord Department of Mechanical Engineering and Materials Science
Thomas Lord Department of Mechanical Engineering and Materials Science
d.needham@duke.edu
3391 FCIEMAS Building, Box 90300, Durham, NC 27708-0300
3391 FCIEMAS Building, Box 90300, Durham, NC 27708

Featured Works

Micro-Surface and -Interfacial Tensions Measured Using the Micropipette Technique: Applications in Ultrasound-Microbubbles, Oil-Recovery, Lung-Surfactants, Nanoprecipitation, and Microfluidics.

Journal article Micromachines · February 2019 Featured Publication This review presents a series of measurements of the surface and interfacial tensions we have been able to make using the micropipette technique. These include: equilibrium tensions at the air-water surface and oil-water interface, as well as equilibrium a ... Full text Cite

Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food".

Journal article Journal of drug targeting · November 2016 Featured Publication The story starts in Basel at CLINAM in 2013, when I asked Pieter about making nanoparticles and he advised me to "try this solvent-exchange method we have developed for making limit sized particles". We are particularly interested in what are "limit size m ... Full text Cite

Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Journal article Cancer Res · November 1, 2012 Featured Publication Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. However, ... Full text Link to item Cite

The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.

Journal article Adv Drug Deliv Rev · December 31, 2001 Featured Publication Our laboratories have been working together in close collaboration for over 10 years concerning the design and performance of lipid-based drug delivery systems. Over the past 3 years we have conceived of, developed, and tested pre-clinically, a new liposom ... Full text Link to item Cite

Water permeability and mechanical strength of polyunsaturated lipid bilayers.

Journal article Biophys J · July 2000 Featured Publication Micropipette aspiration was used to test mechanical strength and water permeability of giant-fluid bilayer vesicles composed of polyunsaturated phosphatidylcholine PC lipids. Eight synthetic-diacyl PCs were chosen with 18 carbon chains and degrees of unsat ... Full text Link to item Cite

Effect of chain length and unsaturation on elasticity of lipid bilayers.

Journal article Biophys J · July 2000 Featured Publication Micropipette pressurization of giant bilayer vesicles was used to measure both elastic bending k(c) and area stretch K(A) moduli of fluid-phase phosphatidylcholine (PC) membranes. Twelve diacyl PCs were chosen: eight with two 18 carbon chains and degrees o ... Full text Link to item Cite

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

Journal article Cancer Res · March 1, 2000 Featured Publication The single biggest challenge now facing drug delivery (for liposomes and indeed other carriers) is to initiate and produce release of the encapsulated drug only at the diseased site and at controllable rates. Our efforts have focused on developing a new th ... Link to item Cite

The "Stealth" liposome: A prototypical biomaterial

Journal article Chemical Reviews · 1995 Featured Publication Cite

Elastic deformation and failure of lipid bilayer membranes containing cholesterol.

Journal article Biophys J · October 1990 Featured Publication Giant bilayer vesicles were reconstituted from several lipids and lipid/cholesterol (CHOL) mixtures: stearolyloleoylphosphatidylcholine (SOPC), bovine sphingomyelin (BSM), diarachidonylphosphatidylcholine (DAPC), SOPC/CHOL, BSM/CHOL, DAPC/CHOL, and extract ... Full text Link to item Cite

Physical properties of surfactant bilayer membranes: Thermal transitions, elasticity, rigidity, cohesion, and colloidal interactions

Journal article Journal of Physical Chemistry · 1987 Featured Publication Simple micromechanical methods provide direct measurements of surface cohesion, elasticity, rigidity, and mutual attraction properties of surfactant double-layer membranes in aqueous media. Temperature-dependent tests yield explicit data for thermal phase ... Cite