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Daniel Levic

Assistant Research Professor of Cell Biology
Cell Biology

Scholarly Works - Preprints


A self-limiting mechanotransduction feedback loop ensures robust organ formation.

Preprint · November 14, 2025 Organ morphogenesis uses mechanotransduction feedback loops to convert forces into gene expression changes that regulate cell mechanics. How these loops integrate with developmental programs to ensure robust outcomes remains unclear. We show Yap mechanotra ... Full text Link to item Cite

Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary.

Preprint · March 19, 2025 The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray's Anatomy, it disappeared from recent textbooks, and is often dismissed as a functionless ves ... Full text Link to item Cite

Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

Preprint · February 12, 2025 AbstractThe rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textb ... Full text Cite

Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary.

Preprint · November 11, 2024 The rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray's Anatomy, it disappeared from recent textbooks, and is often dismissed as a functionless ves ... Full text Link to item Cite

Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

Preprint · May 20, 2024 AbstractThe rete ovarii (RO) is an appendage of the ovary that has been given little attention. Although the RO appears in drawings of the ovary in early versions of Gray’s Anatomy, it disappeared from recent textb ... Full text Cite

TNF promoter hypomethylation is associated with mucosal inflammation in IBD and anti-TNF response.

Preprint · February 6, 2024 BACKGROUND AND AIMS: Inflammatory Bowel Diseases (IBD) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflamma ... Full text Link to item Cite

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2.

Preprint · January 25, 2024 The cardiovascular system generates and responds to mechanical forces. The heartbeat pumps blood through a network of vascular tubes, which adjust their caliber in response to the hemodynamic environment. However, how endothelial cells in the developing va ... Full text Link to item Cite

Regulated extracellular matrix trafficking shapes cell growth during cartilage morphogenesis

Preprint · 2022 Craniofacial malformations are present in more than one third of all congenital syndromes, but the pathogenesis of skeletal dysmorphology is poorly understood. Here, using an unbiased forward genetics approach in zebrafish, we identified a mutation in erc ... Full text Cite

Knock-in tagging in zebrafish facilitated by insertion into non-coding regions

Preprint · 2021 Zebrafish provide an excellent model for in vivo cell biology studies due to their amenability to live imaging. Protein visualization in zebrafish has traditionally relied on overexpression of fluorescently tagged proteins from heterologous promoters, mak ... Full text Cite