Daniel Julio Lew | Scholars@Duke

Daniel Julio Lew
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology

Our research interests focus on the control of cell polarity. Cell polarity is a nearly universal feature of eukaryotic cells. A polarized cell usually has a single, clear axis of asymmetry: a “front” and a “back”. In the past several years it has become apparent that the highly conserved Rho-family GTPase Cdc42, first discovered in yeast, is a component of a master pathway, employed time and again to promote polarity in different contexts.

Most cells know which way to polarize. Concentration gradients of attractants, repellents, nutrients, or pheromones reveal the optimal directions for successful attack, escape, feeding, or mating. However, cells can and do polarize even when deprived of directional cues, choosing a random axis and committing to it as if they knew where they were going. This process, called "symmetry breaking", reflects the presence of a core internal polarity program. Our work has uncovered the biochemical basis for this core program, which uses positive feedback loops to reinforce inequalities in the local concentrations of polarity factors, so that stochastic fluctuations are amplified into a single dominating asymmetry.

We use the tractable budding yeast as a model system. Because the genes and processes we study are highly conserved, we anticipate that learning the answers to fundamental questions in yeast will be relevant and informative for a wide range of organisms. Our work combines molecular genetics, cell biology, and mathematical modeling, and addresses questions including:

Why is there one and only one “front”?
How is polarity turned on and off?
How does Cdc42 organize the cytoskeleton?
How is polarity guided by pheromone gradients?

Current Appointments & Affiliations

James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2006
Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2008
Professor of Cell Biology, Cell Biology, Basic Science Departments 2009
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

C359 Lev Sci Res Ctr, Durham, NC 27708
Duke Box 3813, Durham, NC 27710
daniel.lew@duke.edu (919) 613-8627
Lew Lab

Background
Education, Training, & Certifications
- Ph.D., Rockefeller University 1990
Duke Appointment History
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2008
- Associate Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 2001 - 2006
- Assistant Professor of Genetics, School of Medicine, Duke University 1995 - 2002
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1997 - 2001
- Assistant Professor of Molecular Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1994 - 1997
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Studies of cell polarity, chemotropism, and cell-cycle control awarded by National Institutes of Health 2017 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Program to Support Student Development and Diversity in Duke Biosciences awarded by National Institutes of Health 2013 - 2019
- Mechanisms of cell fusion during mating in Saccharomyces cerevisiae awarded by Burroughs Wellcome Fund 2017 - 2018
- Spatiotemporal modeling of signal transduction in yeast awarded by University of North Carolina - Chapel Hill 2014 - 2018
- Gradient Tracking and Chemotropism awarded by National Institutes of Health 2013 - 2018
- Polarity Establishment in Yeast awarded by National Institutes of Health 2001 - 2017
- Cell Cycle Checkpoint that Monitors Morphogenesis awarded by National Institutes of Health 1995 - 2013
External Relationships
- Gordon Conferences
- Howard Hughes Medical Institute (HHMI)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ramirez, Samuel A., Michael Pablo, Sean Burk, Daniel J. Lew, and Timothy C. Elston. “A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.” Plos Comput Biol 17, no. 7 (July 15, 2021): e1008525. https://doi.org/10.1371/journal.pcbi.1008525.
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  - Ghose, Debraj, Katherine Jacobs, Samuel Ramirez, Timothy Elston, and Daniel Lew. “Chemotactic movement of a polarity site enables yeast cells to find their mates.” Proc Natl Acad Sci U S A 118, no. 22 (June 1, 2021). https://doi.org/10.1073/pnas.2025445118.
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  - Clark-Cotton, Manuella R., Nicholas T. Henderson, Michael Pablo, Debraj Ghose, Timothy C. Elston, and Daniel J. Lew. “Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae.” Mol Biol Cell 32, no. 10 (May 1, 2021): 1048–63. https://doi.org/10.1091/mbc.E21-02-0068.
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  - Chiou, Jian-Geng, Kyle D. Moran, and Daniel J. Lew. “How cells determine the number of polarity sites.” Elife 10 (April 26, 2021). https://doi.org/10.7554/eLife.58768.
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  - Robertson, Corrina G., Manuella R. Clark-Cotton, and Daniel J. Lew. “Mechanisms that ensure monogamous mating in Saccharomyces cerevisiae.” Mol Biol Cell 32, no. 8 (April 15, 2021): 638–44. https://doi.org/10.1091/mbc.E20-12-0757.
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  - Ghose, Debraj, and Daniel Lew. “Mechanistic insights into actin-driven polarity site movement in yeast.” Mol Biol Cell 31, no. 10 (May 1, 2020): 1085–1102. https://doi.org/10.1091/mbc.E20-01-0040.
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  - Moran, Kyle D., and Daniel J. Lew. “How Diffusion Impacts Cortical Protein Distribution in Yeasts.” Cells 9, no. 5 (April 30, 2020). https://doi.org/10.3390/cells9051113.
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  - Mitchison-Field, Lorna M. Y., José M. Vargas-Muñiz, Benjamin M. Stormo, Ellysa J. D. Vogt, Sarah Van Dierdonck, James F. Pelletier, Christoph Ehrlich, Daniel J. Lew, Christine M. Field, and Amy S. Gladfelter. “Unconventional Cell Division Cycles from Marine-Derived Yeasts.” Curr Biol 29, no. 20 (October 21, 2019): 3439-3456.e5. https://doi.org/10.1016/j.cub.2019.08.050.
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  - Henderson, Nicholas T., Michael Pablo, Debraj Ghose, Manuella R. Clark-Cotton, Trevin R. Zyla, James Nolen, Timothy C. Elston, and Daniel J. Lew. “Ratiometric GPCR signaling enables directional sensing in yeast.” Plos Biol 17, no. 10 (October 2019): e3000484. https://doi.org/10.1371/journal.pbio.3000484.
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  - Woods, Benjamin, and Daniel J. Lew. “Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.” Small Gtpases 10, no. 2 (March 2019): 130–37. https://doi.org/10.1080/21541248.2016.1275370.
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  - Moran, Kyle D., Hui Kang, Ana V. Araujo, Trevin R. Zyla, Koji Saito, Denis Tsygankov, and Daniel J. Lew. “Cell-cycle control of cell polarity in yeast.” J Cell Biol 218, no. 1 (January 7, 2019): 171–89. https://doi.org/10.1083/jcb.201806196.
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  - McClure, Allison W., Katherine C. Jacobs, Trevin R. Zyla, and Daniel J. Lew. “Mating in wild yeast: delayed interest in sex after spore germination.” Mol Biol Cell 29, no. 26 (December 15, 2018): 3119–27. https://doi.org/10.1091/mbc.E18-08-0528.
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  - Chiou, Jian-Geng, Samuel A. Ramirez, Timothy C. Elston, Thomas P. Witelski, David G. Schaeffer, and Daniel J. Lew. “Principles that govern competition or co-existence in Rho-GTPase driven polarization.” Plos Comput Biol 14, no. 4 (April 2018): e1006095. https://doi.org/10.1371/journal.pcbi.1006095.
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  - Daniels, Christine N., Trevin R. Zyla, and Daniel J. Lew. “A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.” Plos One 13, no. 12 (2018): e0200863. https://doi.org/10.1371/journal.pone.0200863.
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  - Chiou, Jian-Geng, Mohan K. Balasubramanian, and Daniel J. Lew. “Cell Polarity in Yeast.” Annual Review of Cell and Developmental Biology 33 (October 2017): 77–101. https://doi.org/10.1146/annurev-cellbio-100616-060856.
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  - Kang, Hui, and Daniel J. Lew. “How do cells know what shape they are?” Curr Genet 63, no. 1 (February 2017): 75–77. https://doi.org/10.1007/s00294-016-0623-1.
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  - Woods, Benjamin, Helen Lai, Chi-Fang Wu, Trevin R. Zyla, Natasha S. Savage, and Daniel J. Lew. “Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast.” Curr Biol 26, no. 16 (August 22, 2016): 2114–26. https://doi.org/10.1016/j.cub.2016.06.047.
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  - Kang, Hui, Denis Tsygankov, and Daniel J. Lew. “Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.” Mol Biol Cell 27, no. 11 (June 1, 2016): 1764–75. https://doi.org/10.1091/mbc.E16-01-0014.
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  - McClure, Allison W., Chi-Fang Wu, Sam A. Johnson, and Daniel J. Lew. “Imaging Polarization in Budding Yeast.” Methods Mol Biol 1407 (2016): 13–23. https://doi.org/10.1007/978-1-4939-3480-5_2.
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  - McClure, Allison W., Maria Minakova, Jayme M. Dyer, Trevin R. Zyla, Timothy C. Elston, and Daniel J. Lew. “Role of Polarized G Protein Signaling in Tracking Pheromone Gradients.” Dev Cell 35, no. 4 (November 23, 2015): 471–82. https://doi.org/10.1016/j.devcel.2015.10.024.
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  - Ramirez, Samuel A., Sridhar Raghavachari, and Daniel J. Lew. “Dendritic spine geometry can localize GTPase signaling in neurons.” Mol Biol Cell 26, no. 22 (November 5, 2015): 4171–81. https://doi.org/10.1091/mbc.E15-06-0405.
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  - Wu, C. F., J. G. Chiou, M. Minakova, B. Woods, D. Tsygankov, T. R. Zyla, N. S. Savage, T. C. Elston, and D. J. Lew. “Role of competition between polarity sites in establishing a unique front.” Elife 4, no. NOVEMBER2015 (November 2, 2015). https://doi.org/10.7554/eLife.11611.001.
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  - Wu, Chi-Fang, Jian-Geng Chiou, Maria Minakova, Benjamin Woods, Denis Tsygankov, Trevin R. Zyla, Natasha S. Savage, Timothy C. Elston, and Daniel J. Lew. “Role of competition between polarity sites in establishing a unique front.” Elife 4 (November 2, 2015). https://doi.org/10.7554/eLife.11611.
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  - Woods, Benjamin, Chun-Chen Kuo, Chi-Fang Wu, Trevin R. Zyla, and Daniel J. Lew. “Polarity establishment requires localized activation of Cdc42.” J Cell Biol 211, no. 1 (October 12, 2015): 19–26. https://doi.org/10.1083/jcb.201506108.
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  - McClure, Allison W., and Daniel J. Lew. “To avoid a mating mishap, yeast focus and communicate.” J Cell Biol 208, no. 7 (March 30, 2015): 867–68. https://doi.org/10.1083/jcb.201502095.
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  - McClure, Allison W., and Daniel J. Lew. “Cell polarity: netrin calms an excitable system.” Curr Biol 24, no. 21 (November 3, 2014): R1050–52. https://doi.org/10.1016/j.cub.2014.09.042.
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  - Kuo, Chun-Chen, Natasha S. Savage, Hsin Chen, Chi-Fang Wu, Trevin R. Zyla, and Daniel J. Lew. “Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.” Curr Biol 24, no. 7 (March 31, 2014): 753–59. https://doi.org/10.1016/j.cub.2014.02.024.
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  - Wu, Chi-Fang, and Daniel J. Lew. “Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.” Trends Cell Biol 23, no. 10 (October 2013): 476–83. https://doi.org/10.1016/j.tcb.2013.05.003.
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  - Atkins, Benjamin D., Satoshi Yoshida, Koji Saito, Chi-Fang Wu, Daniel J. Lew, and David Pellman. “Inhibition of Cdc42 during mitotic exit is required for cytokinesis.” J Cell Biol 202, no. 2 (July 22, 2013): 231–40. https://doi.org/10.1083/jcb.201301090.
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  - King, Kindra, Hui Kang, Michelle Jin, and Daniel J. Lew. “Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.” Mol Biol Cell 24, no. 7 (April 2013): 914–22. https://doi.org/10.1091/mbc.E12-11-0812.
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  - Dyer, Jayme M., Natasha S. Savage, Meng Jin, Trevin R. Zyla, Timothy C. Elston, and Daniel J. Lew. “Tracking shallow chemical gradients by actin-driven wandering of the polarization site.” Curr Biol 23, no. 1 (January 7, 2013): 32–41. https://doi.org/10.1016/j.cub.2012.11.014.
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  - Wu, C. -. F., N. S. Savage, T. R. Zyla, and D. J. Lew. “The yeast guanine nucleotide dissociation inhibitor (GDI) enforces singularity by enhancing competition between polarity sites.” Molecular Biology of the Cell 24 (January 1, 2013).
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  - Wu, Chi-Fang, Natasha S. Savage, and Daniel J. Lew. “Interaction between bud-site selection and polarity-establishment machineries in budding yeast.” Philos Trans R Soc Lond B Biol Sci 368, no. 1629 (2013): 20130006. https://doi.org/10.1098/rstb.2013.0006.
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  - King, Kindra, Michelle Jin, and Daniel Lew. “Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering.” Eukaryot Cell 11, no. 12 (December 2012): 1496–1502. https://doi.org/10.1128/EC.00196-12.
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  - Chen, Hsin, Chun-Chen Kuo, Hui Kang, Audrey S. Howell, Trevin R. Zyla, Michelle Jin, and Daniel J. Lew. “Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.” Mol Biol Cell 23, no. 19 (October 2012): 3814–26. https://doi.org/10.1091/mbc.E12-05-0400.
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  - Savage, Natasha S., Anita T. Layton, and Daniel J. Lew. “Mechanistic mathematical model of polarity in yeast.” Mol Biol Cell 23, no. 10 (May 2012): 1998–2013. https://doi.org/10.1091/mbc.E11-10-0837.
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  - Howell, Audrey S., Meng Jin, Chi-Fang Wu, Trevin R. Zyla, Timothy C. Elston, and Daniel J. Lew. “Negative feedback enhances robustness in the yeast polarity establishment circuit.” Cell 149, no. 2 (April 13, 2012): 322–33. https://doi.org/10.1016/j.cell.2012.03.012.
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  - Howell, Audrey S., and Daniel J. Lew. “Morphogenesis and the cell cycle.” Genetics 190, no. 1 (January 2012): 51–77. https://doi.org/10.1534/genetics.111.128314.
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  - Wu, C. -. F., and D. J. Lew. “The yeast guanine nucleotide dissociation inhibitor (GDI) enforces singularity by enhancing competition between polarity sites.” Molecular Biology of the Cell 23 (January 1, 2012).
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  - Johnson, Jayme M., Meng Jin, and Daniel J. Lew. “Symmetry breaking and the establishment of cell polarity in budding yeast.” Curr Opin Genet Dev 21, no. 6 (December 2011): 740–46. https://doi.org/10.1016/j.gde.2011.09.007.
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  - Chen, Hsin, Audrey S. Howell, Alex Robeson, and Daniel J. Lew. “Dynamics of septin ring and collar formation in Saccharomyces cerevisiae.” Biol Chem 392, no. 8–9 (August 2011): 689–97. https://doi.org/10.1515/BC.2011.075.
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  - Layton, Anita T., Natasha S. Savage, Audrey S. Howell, Susheela Y. Carroll, David G. Drubin, and Daniel J. Lew. “Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.” Curr Biol 21, no. 3 (February 8, 2011): 184–94. https://doi.org/10.1016/j.cub.2011.01.012.
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  - Howell, Audrey S., Natasha S. Savage, Sam A. Johnson, Indrani Bose, Allison W. Wagner, Trevin R. Zyla, H Frederik Nijhout, Michael C. Reed, Andrew B. Goryachev, and Daniel J. Lew. “Singularity in polarization: rewiring yeast cells to make two buds.” Cell 139, no. 4 (November 13, 2009): 731–43. https://doi.org/10.1016/j.cell.2009.10.024.
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  - Crutchley, John, Kindra M. King, Mignon A. Keaton, Lee Szkotnicki, David A. Orlando, Trevin R. Zyla, Elaine S. G. Bardes, and Daniel J. Lew. “Molecular dissection of the checkpoint kinase Hsl1p.” Mol Biol Cell 20, no. 7 (April 2009): 1926–36. https://doi.org/10.1091/mbc.e08-08-0848.
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  - Kozubowski, L., K. Saito, J. M. Johnson, A. S. Howell, and D. J. Lew. “Response: GEF localization, not just activation, is needed for yeast polarity establishment.” Current Biology 19, no. 5 (March 10, 2009). https://doi.org/10.1016/j.cub.2009.01.022.
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  - Lew, Daniel J., and Michael P. Rout. “Cell structure and dynamics.” Curr Opin Cell Biol 21, no. 1 (February 2009): 1–3. https://doi.org/10.1016/j.ceb.2009.01.010.
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  - Kozubowski, Lukasz, Koji Saito, Jayme M. Johnson, Audrey S. Howell, Trevin R. Zyla, and Daniel J. Lew. “Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.” Curr Biol 18, no. 22 (November 25, 2008): 1719–26. https://doi.org/10.1016/j.cub.2008.09.060.
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  - Szkotnicki, Lee, John M. Crutchley, Trevin R. Zyla, Elaine S. G. Bardes, and Daniel J. Lew. “The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.” Mol Biol Cell 19, no. 11 (November 2008): 4675–86. https://doi.org/10.1091/mbc.e08-06-0663.
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  - Keaton, Mignon A., Lee Szkotnicki, Aron R. Marquitz, Jake Harrison, Trevin R. Zyla, and Daniel J. Lew. “Nucleocytoplasmic trafficking of G2/M regulators in yeast.” Mol Biol Cell 19, no. 9 (September 2008): 4006–18. https://doi.org/10.1091/mbc.e08-03-0286.
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  - Lew, Daniel J., Daniel J. Burke, and Anindya Dutta. “The immortal strand hypothesis: how could it work?” Cell 133, no. 1 (April 4, 2008): 21–23. https://doi.org/10.1016/j.cell.2008.03.016.
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  - York, John D., and Daniel J. Lew. “IP7 guards the CDK gate.” Nat Chem Biol 4, no. 1 (January 2008): 16–17. https://doi.org/10.1038/nchembio0108-16.
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  - Tong, Zongtian, Xiang-Dong Gao, Audrey S. Howell, Indrani Bose, Daniel J. Lew, and Erfei Bi. “Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition.” J Cell Biol 179, no. 7 (December 31, 2007): 1375–84. https://doi.org/10.1083/jcb.200705160.
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  - Keaton, Mignon A., Elaine S. G. Bardes, Aron R. Marquitz, Christopher D. Freel, Trevin R. Zyla, Johannes Rudolph, and Daniel J. Lew. “Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.” Curr Biol 17, no. 14 (July 17, 2007): 1181–89. https://doi.org/10.1016/j.cub.2007.05.075.
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  - Haase, Steven B., and Daniel J. Lew. “Microtubule organization: cell shape is destiny.” Curr Biol 17, no. 7 (April 3, 2007): R249–51. https://doi.org/10.1016/j.cub.2007.02.003.
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  - Keaton, Mignon A., and Daniel J. Lew. “Eavesdropping on the cytoskeleton: progress and controversy in the yeast morphogenesis checkpoint.” Curr Opin Microbiol 9, no. 6 (December 2006): 540–46. https://doi.org/10.1016/j.mib.2006.10.004.
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  - Lew, Daniel J. “Yeast polarity: negative feedback shifts the focus.” Curr Biol 15, no. 24 (December 20, 2005): R994–96. https://doi.org/10.1016/j.cub.2005.11.048.
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  - McNulty, John J., and Daniel J. Lew. “Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae.” Curr Biol 15, no. 24 (December 20, 2005): 2190–98. https://doi.org/10.1016/j.cub.2005.11.039.
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  - Gladfelter, Amy S., Lukasz Kozubowski, Trevin R. Zyla, and Daniel J. Lew. “Interplay between septin organization, cell cycle and cell shape in yeast.” J Cell Sci 118, no. Pt 8 (April 15, 2005): 1617–28. https://doi.org/10.1242/jcs.02286.
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  - Irazoqui, Javier E., Audrey S. Howell, Chandra L. Theesfeld, and Daniel J. Lew. “Opposing roles for actin in Cdc42p polarization.” Mol Biol Cell 16, no. 3 (March 2005): 1296–1304. https://doi.org/10.1091/mbc.e04-05-0430.
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  - Gladfelter, Amy S., Trevin R. Zyla, and Daniel J. Lew. “Genetic interactions among regulators of septin organization.” Eukaryot Cell 3, no. 4 (August 2004): 847–54. https://doi.org/10.1128/EC.3.4.847-854.2004.
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  - Irazoqui, Javier E., Amy S. Gladfelter, and Daniel J. Lew. “Cdc42p, GTP hydrolysis, and the cell's sense of direction.” Cell Cycle 3, no. 7 (July 2004): 861–64.
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  - Irazoqui, Javier E., and Daniel J. Lew. “Polarity establishment in yeast.” J Cell Sci 117, no. Pt 11 (May 1, 2004): 2169–71. https://doi.org/10.1242/jcs.00953.
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  - Harrison, Jacob C., Trevin R. Zyla, Elaine S. G. Bardes, and Daniel J. Lew. “Stress-specific activation mechanisms for the "cell integrity" MAPK pathway.” J Biol Chem 279, no. 4 (January 23, 2004): 2616–22. https://doi.org/10.1074/jbc.M306110200.
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  - Irazoqui, Javier E., Amy S. Gladfelter, and Daniel J. Lew. “Scaffold-mediated symmetry breaking by Cdc42p.” Nat Cell Biol 5, no. 12 (December 2003): 1062–70. https://doi.org/10.1038/ncb1068.
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  - Lew, Daniel J. “The morphogenesis checkpoint: how yeast cells watch their figures.” Curr Opin Cell Biol 15, no. 6 (December 2003): 648–53. https://doi.org/10.1016/j.ceb.2003.09.001.
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  - Theesfeld, Chandra L., Trevin R. Zyla, Elaine G. S. Bardes, and Daniel J. Lew. “A monitor for bud emergence in the yeast morphogenesis checkpoint.” Mol Biol Cell 14, no. 8 (August 2003): 3280–91. https://doi.org/10.1091/mbc.e03-03-0154.
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  - Lew, Daniel J., and Daniel J. Burke. “The spindle assembly and spindle position checkpoints.” Annu Rev Genet 37 (2003): 251–82. https://doi.org/10.1146/annurev.genet.37.042203.120656.
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  - McMillan, John N., Chandra L. Theesfeld, Jacob C. Harrison, Elaine S. G. Bardes, and Daniel J. Lew. “Determinants of Swe1p degradation in Saccharomyces cerevisiae.” Mol Biol Cell 13, no. 10 (October 2002): 3560–75. https://doi.org/10.1091/mbc.e02-05-0283.
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  - Marquitz, Aron R., Jacob C. Harrison, Indrani Bose, Trevin R. Zyla, John N. McMillan, and Daniel J. Lew. “The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint.” Embo J 21, no. 15 (August 1, 2002): 4012–25. https://doi.org/10.1093/emboj/cdf416.
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  - Lew, Daniel J. “Formin' actin filament bundles.” Nat Cell Biol 4, no. 2 (February 2002): E29–30. https://doi.org/10.1038/ncb0202-e29.
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  - Gladfelter, Amy S., Indrani Bose, Trevin R. Zyla, Elaine S. G. Bardes, and Daniel J. Lew. “Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.” J Cell Biol 156, no. 2 (January 21, 2002): 315–26. https://doi.org/10.1083/jcb.200109062.
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  - Gladfelter, A. S., J. R. Pringle, and D. J. Lew. “The septin cortex at the yeast mother-bud neck.” Curr Opin Microbiol 4, no. 6 (December 2001): 681–89. https://doi.org/10.1016/s1369-5274(01)00269-7.
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  - Adamo, J. E., J. J. Moskow, A. S. Gladfelter, D. Viterbo, D. J. Lew, and P. J. Brennwald. “Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.” J Cell Biol 155, no. 4 (November 12, 2001): 581–92. https://doi.org/10.1083/jcb.200106065.
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  - Marquitz, A. R., J. C. Harrison, C. L. Theesfeld, E. S. G. Bardes, and D. J. Lew. “The Rho GAP Bem2p plays a role in the morphogenesis checkpoint of Saccharomyces cerevisiae.” Molecular Biology of the Cell 12 (November 1, 2001): 408A-408A.
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  - Theesfeld, C. L., and D. J. Lew. “Septin-dependent monitoring of local cell shape in the yeast morphogenesis checkpoint.” Molecular Biology of the Cell 12 (November 1, 2001): 142A-143A.
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  - Adamo, J. E., J. J. Moskow, A. S. Gladfelter, D. Viterbo, D. J. Lew, and P. J. Brennwald. “Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.” Journal of Cell Biology 155, no. 3 (October 29, 2001): 581–92. https://doi.org/10.1083/jcb.200106065.
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  - Theesfeld, C. L., E. Bardes, and D. J. Lew. “Hsl1 as a sensor of cell shape.” Yeast 18 (August 1, 2001): S142–S142.
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  - Gladfelter, A. S., J. J. Moskow, T. R. Zyla, and D. J. Lew. “Isolation and characterization of effector-loop mutants of CDC42 in yeast.” Mol Biol Cell 12, no. 5 (May 2001): 1239–55. https://doi.org/10.1091/mbc.12.5.1239.
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  - Harrison, J. C., E. S. Bardes, Y. Ohya, and D. J. Lew. “A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint.” Nat Cell Biol 3, no. 4 (April 2001): 417–20. https://doi.org/10.1038/35070104.
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  - Bose, I., J. E. Irazoqui, J. J. Moskow, E. S. Bardes, T. R. Zyla, and D. J. Lew. “Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.” J Biol Chem 276, no. 10 (March 9, 2001): 7176–86. https://doi.org/10.1074/jbc.M010546200.
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  - Yeh, E., C. Yang, E. Chin, P. Maddox, E. D. Salmon, D. J. Lew, and K. Bloom. “Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants.” Mol Biol Cell 11, no. 11 (November 2000): 3949–61. https://doi.org/10.1091/mbc.11.11.3949.
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  - Moskow, J. J., A. S. Gladfelter, R. E. Lamson, P. M. Pryciak, and D. J. Lew. “Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.” Mol Cell Biol 20, no. 20 (October 2000): 7559–71. https://doi.org/10.1128/MCB.20.20.7559-7571.2000.
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  - Longtine, M. S., C. L. Theesfeld, J. N. McMillan, E. Weaver, J. R. Pringle, and D. J. Lew. “Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae.” Mol Cell Biol 20, no. 11 (June 2000): 4049–61. https://doi.org/10.1128/MCB.20.11.4049-4061.2000.
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  - Lew, D. J. “Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae.” Curr Opin Genet Dev 10, no. 1 (February 2000): 47–53. https://doi.org/10.1016/s0959-437x(99)00051-9.
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  - Kim, J. M., K. H. Chang, Y. H. Choi, Y. G. Song, S. M. Kang, T. Y. Yoon, J. M. Choi, S. Y. Park, and D. J. Lew. “Seroprevalence of HTLV-I in Cheju Island, a Korean island adjacent to the endemic area of Japan.” J Acquir Immune Defic Syndr 22, no. 4 (December 1, 1999): 409–12. https://doi.org/10.1097/00126334-199912010-00016.
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  - Gladfelter, A. S., J. J. Moskow, and D. J. Lew. “Analysis of cdc42effector loop mutants in budding yeast.” Molecular Biology of the Cell 10 (November 1, 1999): 54A-54A.
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  - Lew, D. J. “Cell cycle and checkpoint control of Swe1p localization and degradation.” Molecular Biology of the Cell 10 (November 1, 1999): 3A-3A.
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  - McMillan, J. N., M. S. Longtine, R. A. Sia, C. L. Theesfeld, E. S. Bardes, J. R. Pringle, and D. J. Lew. “The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p.” Mol Cell Biol 19, no. 10 (October 1999): 6929–39. https://doi.org/10.1128/MCB.19.10.6929.
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  - Theesfeld, C. L., J. E. Irazoqui, K. Bloom, and D. J. Lew. “The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle.” J Cell Biol 146, no. 5 (September 6, 1999): 1019–32. https://doi.org/10.1083/jcb.146.5.1019.
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  - McMillan, J. N., R. A. Sia, E. S. Bardes, and D. J. Lew. “Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint.” Mol Cell Biol 19, no. 9 (September 1999): 5981–90. https://doi.org/10.1128/MCB.19.9.5981.
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  - Sia, R. A., E. S. Bardes, and D. J. Lew. “Control of Swe1p degradation by the morphogenesis checkpoint.” Embo J 17, no. 22 (November 16, 1998): 6678–88. https://doi.org/10.1093/emboj/17.22.6678.
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  - McMillan, J. N., R. A. Sia, and D. J. Lew. “A morphogenesis checkpoint monitors the actin cytoskeleton in yeast.” J Cell Biol 142, no. 6 (September 21, 1998): 1487–99. https://doi.org/10.1083/jcb.142.6.1487.
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  - Bi, E., P. Maddox, D. J. Lew, E. D. Salmon, J. N. McMillan, E. Yeh, and J. R. Pringle. “Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis.” J Cell Biol 142, no. 5 (September 7, 1998): 1301–12. https://doi.org/10.1083/jcb.142.5.1301.
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  - Kaiser, P., R. A. Sia, E. G. Bardes, D. J. Lew, and S. I. Reed. “Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.” Genes Dev 12, no. 16 (August 15, 1998): 2587–97. https://doi.org/10.1101/gad.12.16.2587.
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  - Haase, S. B., and D. J. Lew. “Flow cytometric analysis of DNA content in budding yeast.” Methods Enzymol 283 (1997): 322–32. https://doi.org/10.1016/s0076-6879(97)83026-1.
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  - Lew, D. J., and S. Kornbluth. “Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.” Curr Opin Cell Biol 8, no. 6 (December 1996): 795–804. https://doi.org/10.1016/s0955-0674(96)80080-9.
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  - McMillan, J. N., and D. J. Lew. “Genetic screen to uncover proteins involved in the morphogenesis cell cycle checkpoint in budding yeast.” Molecular Biology of the Cell 7 (December 1, 1996): 2077–2077.
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  - Sia, R. A., H. A. Herald, and D. J. Lew. “Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.” Mol Biol Cell 7, no. 11 (November 1996): 1657–66. https://doi.org/10.1091/mbc.7.11.1657.
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  - Lew, D. J., and S. I. Reed. “A cell cycle checkpoint monitors cell morphogenesis in budding yeast.” J Cell Biol 129, no. 3 (May 1995): 739–49. https://doi.org/10.1083/jcb.129.3.739.
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  - Parks, B., S. Spielman, J. Orenstein, D. T. Nemeth, F. Ludwig, J. Clarke, P. Merchant, and D. J. Lew. “Phase-sensitive measurements of vortex dynamics in the terahertz domain.” Phys Rev Lett 74, no. 16 (April 17, 1995): 3265–68. https://doi.org/10.1103/PhysRevLett.74.3265.
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  - Lew, D. J., and S. I. Reed. “Cell cycle control of morphogenesis in budding yeast.” Curr Opin Genet Dev 5, no. 1 (February 1995): 17–23. https://doi.org/10.1016/s0959-437x(95)90048-9.
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  - Spielman, S., B. Parks, J. Orenstein, D. T. Nemeth, F. Ludwig, J. Clarke, P. Merchant, and D. J. Lew. “Observation of the quasiparticle Hall effect in superconducting YBa2Cu3O7- delta.” Phys Rev Lett 73, no. 11 (September 12, 1994): 1537–40. https://doi.org/10.1103/PhysRevLett.73.1537.
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  - Stueland, C. S., D. J. Lew, M. J. Cismowski, and S. I. Reed. “Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae.” Mol Cell Biol 13, no. 6 (June 1993): 3744–55. https://doi.org/10.1128/mcb.13.6.3744-3755.1993.
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  - Lew, D. J., and S. I. Reed. “Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins.” J Cell Biol 120, no. 6 (March 1993): 1305–20. https://doi.org/10.1083/jcb.120.6.1305.
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  - Lew, D. J., N. J. Marini, and S. I. Reed. “A suppressor of cln3 for size control.” Cell 72, no. 4 (February 26, 1993): 488–89. https://doi.org/10.1016/0092-8674(93)90068-2.
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  - Richardson, H., D. J. Lew, M. Henze, K. Sugimoto, and S. I. Reed. “Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.” Genes Dev 6, no. 11 (November 1992): 2021–34. https://doi.org/10.1101/gad.6.11.2021.
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  - Lew, D. J., N. J. Marini, and S. I. Reed. “Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells of the budding yeast S. cerevisiae.” Cell 69, no. 2 (April 17, 1992): 317–27. https://doi.org/10.1016/0092-8674(92)90412-6.
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  - Lew, D. J., and S. I Reed. “A proliferation of cyclins.” Trends Cell Biol 2, no. 3 (March 1992): 77–81. https://doi.org/10.1016/0962-8924(92)90076-y.
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  - Lu, X. P., K. S. Koch, D. J. Lew, V. Dulic, J. Pines, S. I. Reed, T. Hunter, and H. L. Leffert. “Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration.” J Biol Chem 267, no. 5 (February 15, 1992): 2841–44.
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  - Reed, S. I., V. Dulic, D. J. Lew, H. E. Richardson, and C. Wittenberg. “G1 control in yeast and animal cells.” Ciba Found Symp 170 (1992): 7–15. https://doi.org/10.1002/9780470514320.ch2.
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  - Decker, T., D. J. Lew, and J. E. Darnell. “Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.” Mol Cell Biol 11, no. 10 (October 1991): 5147–53. https://doi.org/10.1128/mcb.11.10.5147-5153.1991.
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  - Lew, D. J., V. Dulić, and S. I. Reed. “Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.” Cell 66, no. 6 (September 20, 1991): 1197–1206. https://doi.org/10.1016/0092-8674(91)90042-w.
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  - Lew, D. J., and S. M. Simon. “Characterization of constitutive exocytosis in the yeast Saccharomyces cerevisiae.” J Membr Biol 123, no. 3 (September 1991): 261–68. https://doi.org/10.1007/BF01870409.
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  - Ghiara, J. B., H. E. Richardson, K. Sugimoto, M. Henze, D. J. Lew, C. Wittenberg, and S. I. Reed. “A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis.” Cell 65, no. 1 (April 5, 1991): 163–74. https://doi.org/10.1016/0092-8674(91)90417-w.
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  - Decker, T., D. J. Lew, J. Mirkovitch, and J. E. Darnell. “Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.” Embo J 10, no. 4 (April 1991): 927–32.
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  - Lew, D. J., T. Decker, I. Strehlow, and J. E. Darnell. “Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.” Mol Cell Biol 11, no. 1 (January 1991): 182–91. https://doi.org/10.1128/mcb.11.1.182-191.1991.
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  - Reed, S. I., C. Wittenberg, D. J. Lew, V. Dulic, and M. Henze. “G1 control in yeast and animal cells.” Cold Spring Harb Symp Quant Biol 56 (1991): 61–67. https://doi.org/10.1101/sqb.1991.056.01.009.
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  - Reed, S. I., C. Wittenberg, D. J. Lew, V. Dulic, and M. Henze. “G₁ control in yeast and animal cells.” Cold Spring Harbor Symposia on Quantitative Biology 56 (1991): 61–68.
  - Levy, D. E., D. J. Lew, T. Decker, D. S. Kessler, and J. E. Darnell. “Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.” Embo J 9, no. 4 (April 1990): 1105–11.
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  - Lew, D. J., T. Decker, and J. E. Darnell. “Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.” Mol Cell Biol 9, no. 12 (December 1989): 5404–11. https://doi.org/10.1128/mcb.9.12.5404-5411.1989.
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  - Decker, T., D. J. Lew, Y. S. Cheng, D. E. Levy, and J. E. Darnell. “Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.” Embo J 8, no. 7 (July 1989): 2009–14.
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  - Bookchin, R. M., D. J. Lew, T. Balazs, Y. Ueda, and V. L. Lew. “Dehydration and delayed proton equilibria of red blood cells suspended in isosmotic phosphate buffers. Implications for studies of sickled cells.” J Lab Clin Med 104, no. 6 (December 1984): 855–66.
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- Book Sections
  - Lew, D. J. “Cell Cycle.” In Brenner’s Encyclopedia of Genetics: Second Edition, 456–64, 2013. https://doi.org/10.1016/B978-0-12-374984-0.00206-0.
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- Conference Papers
  - Ramirez, Samuel A., Michael Pablo, Sean Burk, Daniel J. Lew, and Timothy C. Elston. “A Novel Stochastic Simulation Approach Enables Exploration of Mechanisms to Regulate Polarization Dynamics.” In Biophysical Journal, 118:135A-135A. CELL PRESS, 2020.
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  - Clark-Cotton, M. R., and D. J. Lew. “Choosing a mate: Interplay between cell-cell communication and cell polarity in yeast.” In Molecular Biology of the Cell, Vol. 29. AMER SOC CELL BIOLOGY, 2018.
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  - Ghose, D., T. C. Elston, and D. J. Lew. “A budding yeast's polarity site biases its movement up pheromone gradients.” In Molecular Biology of the Cell, Vol. 29. AMER SOC CELL BIOLOGY, 2018.
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  - Moran, K. D., H. Kang, A. V. Araujo, T. R. Zyla, K. Saito, D. Tsygankov, and D. J. Lew. “Understanding cell-cycle regulation of cell polarity in Saccharomyces cerevisiae.” In Molecular Biology of the Cell, Vol. 29. AMER SOC CELL BIOLOGY, 2018.
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  - Ghose, D., D. J. Lew, and T. C. Elston. “Chemotropism in yeast.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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  - Daniels, C. N., and D. J. Lew. “A novel role for Cdc42 effectors Gic1/2 in cell polarity.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.
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  - Kang, H., and D. J. Lew. “Elm1 regulates Hsl1/Hsl7 interaction in the morphogenesis checkpoint.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.
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  - Woods, B., H. Lai, C. Wu, C. Kuo, T. Zyla, and D. J. Lew. “Polarity establishment requires localized activation of Cdc42 by its GEF.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.
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  - Lai, H., T. Zyla, and D. J. Lew. “Regulation of pheromone-induced cell polarization by the polarisome proteins in yeast.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
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  - Woods, B., C. Wu, T. Zyla, N. Savage, and D. J. Lew. “A GDI-independent mechanism to concentrate the Rho-GTPase Cdc42 during polarity establishment.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
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  - Chen, H., A. S. Howell, H. Kang, and D. J. Lew. “How does Cdc42p polarize actin cables?” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.
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  - Howell, A. S., J. E. Irazoqui, C. L. Theesfeld, and D. J. Lew. “Opposing roles for actin in Cdc42p polarization.” In Molecular Biology of the Cell, 15:335A-335A. AMER SOC CELL BIOLOGY, 2004.
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  - Kozubowski, L., J. R. Larson, D. J. Lew, and K. Tatchell. “Exploring the basis for the asymmetry of septin-dependent proteins at the mother-bud neck in Saccharomyces cerevisiae.” In Molecular Biology of the Cell, 15:46A-46A. AMER SOC CELL BIOLOGY, 2004.
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  - McNulty, J. J., and D. J. Lew. “Bud size doesnt matter.” In Molecular Biology of the Cell, 15:20A-20A. AMER SOC CELL BIOLOGY, 2004.
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  - Irazoqui, J. E., and D. J. Lew. “The role of F-actin in Cdc42p polarization.” In Yeast, 20:S67–S67. JOHN WILEY & SONS LTD, 2003.
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  - Harrison, J. C., E. G. Bardes, T. R. Zyla, and D. J. Lew. “Stress-specific activation mechanisms for the "cell integrity" MAPK pathway in Saccharomyces cerevisiae.” In Molecular Biology of the Cell, 13:294A-294A. AMER SOC CELL BIOLOGY, 2002.
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  - Irazoqui, J. E., and D. J. Lew. “Bem1p is required for Cdc42p polarization in the absence of bud site selection.” In Molecular Biology of the Cell, 13:200A-200A. AMER SOC CELL BIOLOGY, 2002.
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