Scholars@Duke
Daniel Philip Nussbaum

Daniel Philip Nussbaum

Associate Professor of Surgery
Surgical Oncology
daniel.nussbaum@duke.edu
DUMC 2612, Durham, NC 27710
DUMC 2612, Durham, NC 27710

Scholarly Works - Preprints

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers.

Preprint · November 2, 2023 Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treat ... Full text Link to item Cite