Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Investigator, Immunology, Schepens Eye Research Institute, Harvard Medical School 2009 - 2012
  • Instructor, Ophthalmology, Harvard Medical School 2010 - 2012
  • Research Fellow, Schepens Eye Research Instittute, Harvard Medical School 2006 - 2009
  • Ph.D., University of Florida 2005
  • M.S., University of Florida 2002
• 

  Duke Appointment History

  • Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2012 - 2017
  • Instructor in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2012
• Research
• 

  Selected Grants

  • Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2022
  • Cellular and Molecular Mechanisms that Contribute to Ocular Surface Disease during Severe Allergic Inflammation awarded by National Institutes of Health 2012 - 2021
  • Immunophenotyping the effect of Xiidra treatment in the inflammatory dry eye disease setting with underlying meibomian gland dysfunction awarded by Shire Pharmaceutical Development US Inc. 2018 - 2020
  • Innate immunity, lipoproteins and AMD progression awarded by National Institutes of Health 2016 - 2019
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by University of Alabama at Birmingham 2017 - 2019
  • Monocytes in Dry Age-Related Macular Degeneration awarded by National Institutes of Health 2016 - 2019
  • Role of bona fide microglia in retinal degeneration awarded by BrightFocus Foundation 2017 - 2019
  • Basic Immunology Training Program awarded by National Institutes of Health 2014 - 2019
  • RPB: 2014 Nelson Trust Award awarded by Research To Prevent Blindness, Inc. 2014 - 2019
  • Evaluation of the effects of topically administered IL-17 antagonist compound on ocular allergy parameters in the severe allergic eye disease (AED) mouse model awarded by Allergan, Inc. 2016 - 2019
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution awarded by Schepens Eye Research Institute 2014 - 2018
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
  • The role of a macrophage chemotactic factor in AMD awarded by BrightFocus Foundation 2015 - 2017
  • Examining the role of IFN-g+IL-17+ pathogenic Th17 cells in severe ocular allergy awarded by National Institutes of Health 2015 - 2017
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by The Trustees of Indiana University 2015 - 2017
  • Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
  • Bone marrow neuropathy drives diabetic retinopathy awarded by The Trustees of Indiana University 2013 - 2016
  • Neuroinflammation: the role of lymphocytes in glaucoma awarded by BrightFocus Foundation 2014 - 2016
  • Molecular Mechanisms of Corneal Recurrent Erosion Formation awarded by The George Washington University 2013 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Saban, DR, and MasLi, S. "Pathobiology of Immune-Mediated Diseases of the Ocular Surface." In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, 2055-2071. January 1, 2014.  Full Text
    • Saban, DR, Dastjerdi, MH, and Dana, R. "Corneal graft rejection." 56-63. 2010.  Full Text

  • Conference Papers

    • Saban, DR, Reyes, N, Mathew, R, Yu, C, Kalnitsky, J, Perez, VL, and Gupta, P. "Tear leukocyte phenotyping in meibomian gland dysfunction by large parameter flow cytometry." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Honolulu, HI. April 29, 2018 - May 3, 2018.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, July 1, 2018.  Link to Item
    • Steven, P, Schwab, S, Saban, DR, Niederkorn, JY, and Gehlsen, U. "Role of Antigen-presenting Cells within Conjunctiva-associated Lymphoid Tissue in the Induction of Ocular Allergy." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Honolulu, HI. April 29, 2018 - May 3, 2018.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, July 1, 2018.  Link to Item
    • Jia, W, Poe, JC, Su, H, Matsushima, GK, Rathmell, J, Imai, K, Reyes, NJ, Cardona, DM, Anand, S, Deoliveira, D, Li, Z, Saban, DR, Chen, BJ, Chao, NJ, and Sarantopoulos, S. "Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd." December 2, 2016.  Link to Item
    • Okoren, E, Mathew, R, and Saban, DR. "Microglia and monocyte-derived macrophage responses to light damage differ across mouse strains." September 2016.  Link to Item
    • Reyes, N, and Saban, DR. "Pathogenesis of meibomian gland dysfunction (MGD) requires the T cell-neutrophil axis, in the allergy setting." September 2016.  Link to Item
    • Smith, R, Reyes, N, and Saban, DR. "Allergic eye disease (AED) progression in the mouse model is associated with quantitative changes in conjunctival innate lymphoid populations." September 2016.  Link to Item
    • Zaki, MA, Galatowicz, G, Eskandarpour, M, Dale-Ahadome, SB, Saban, DR, and Calder, VL. "IL-9 upregulation in experimetal allergic conjunctivitis: IL-9R blockade downregulates mast cell responses." August 2016.  Link to Item
    • Blanco, T, and Saban, DR. "Intravital multiphoton visualization identifies inter-networking between nerves and bone marrow derived cells of the mouse cornea." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Dale, SB, Mathew, R, Reyes, N, Blanco, T, Calder, VL, and Saban, DR. "A novel contribution for dendritic cells in fibrosis pathobiology as revealed in a mouse model of severe ocular allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Kodati, S, Chen, Y, Dohlman, TH, Chauhan, SK, Saban, DR, and Dana, R. "CCR7 is critical in the induction and maintenance of Th17 immunity in dry eye disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Mathew, R, Reyes, N, Blanco, T, and Saban, DR. "Corneal Lymphangiogenesis Contributes to Egress of Corneal Dendritic Cells in a Mouse Model of Ocular Allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • McNabb, RP, Blanco, T, Saban, DR, Izatt, JA, and Kuo, AN. "Single Source Fluorescence Imaging/Blue Optical Coherence Tomography in a GFP Mouse Model." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Reyes, N, Blanco, T, Mathew, R, and Saban, DR. "Novel Mouse Model of Severe Ocular Allergy Reveals a Key Role for Pathogenic Th17 Cells." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Smith, R, Reyes, N, and Saban, DR. "Dendritic cell derived thrombospondin-1 modulation of primary versus secondary T cell responses in a mouse model of ocular allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Stepp, MA, Saban, DR, Ghosh, SP, Pajoohesh-Ganji, A, Tadvalkar, G, Cataisson, C, and Menko, AS. "Resolving wounds induce a more robust cytokine mRNA response and recruitment of larger numbers of neutrophils." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Grant, MB, Bhatwadekar, AD, Hu, P, Hazra, S, Caballero, S, Mohr, S, Abcouwer, SF, Saban, DR, Chan-Ling, T, Busik, JV, and Raizada, MK. "In Type 1 Diabetes Decreased Bone Marrow Neuronal Support Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 Monocytes." November 20, 2012.  Link to Item
    • Chauhan, S, Jin, Y, Goyal, S, Okanobo, A, Lee, H, Saban, DR, and Dana, R. "Th17/IL17 Mediates Autoimmunity-Dependent Corneal Lymphangiogenesis in Dry Eye Disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Chen, Y, Chauhan, SK, Okanobo, A, Saban, DR, and Dana, R. "Regulatory Effects of Early NK Cell Responses on Adaptive Immunity in Dry Eye Disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Hos, D, Bock, F, Saban, DR, Regenfuss, B, Onderka, J, Masli, S, Dana, R, and Cursiefen, C. "Corticosteroids Inhibit Inflammatory Corneal Lymphangigenesis in vivo, but Display Proangiogenic Properties in vitro." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Identification and Function of Novel Langerin Positive Dendritic Cells in the Cornea." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Phenotypic and Functional Characterization of Corneal Langerhans Cells in Transplantation." 2009.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Chimeric Solid Tissue Grafts Diminish Allospecific Immunity." April 2008.  Link to Item
    • Saban, DR, Grant, MB, Nguyen, C, Cornelius, JG, and Peck, AB. "Immunization of cellular antigens into the anterior chamber impairs cytotoxicity." April 1, 2006.  Link to Item
    • Saban, DR, Schwartzkoppf, J, Peck, AB, and Grant, MB. "Preferential production of distinct IgG subclasses in response to anterior chamber immunization with allosplenocytes." 2005.  Link to Item
    • Haire, SE, Elder, IA, Saban, DR, Janssen, JJ, and Timmers, AMM. "Optimization of lentiviral gene delivery to the retinal pigment epithelium in vivo." May 2003.  Link to Item
    • Timmers, AM, Nguyen, TB, Elder, IA, and Saban, DR. "Lentiviral delivery of DH-sCNTF to RPE in P23H rats rescues photoreceptor cells morphologically but not functionally." May 2002.  Link to Item
    • el Samman, TMI, Saban, DR, Elder, IA, Nguyen, TB, Grant, MB, and Timmers, AM. "Prolongation of recombinant adenoviral expression through modulation of the innate ocular immunity." May 2002.  Link to Item
    • Timmers, AM, Nguyen, TB, Saban, DR, and Grant, MB. "Viral vectors for efficient gene delivery to RPE cells." March 15, 2001.  Link to Item

  • Journal Articles

    • Reyes, NJ, Mathew, R, and Saban, DR. "Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease.(Accepted)" Methods in Molecular Biology (Clifton, N.J.) 1834 (January 2019): 153-164.  Full Text
    • Poe, JC, Jia, W, Di Paolo, JA, Reyes, NJ, Kim, JY, Su, H, Sundy, JS, Cardones, AR, Perez, VL, Chen, BJ, Chao, NJ, Cardona, DM, Saban, DR, and Sarantopoulos, S. "SYK inhibitor entospletinib prevents ocular and skin GVHD in mice." Jci Insight 3, no. 19 (October 4, 2018).  Full Text
    • Saban, DR, Hodges, RR, Mathew, R, Reyes, NJ, Yu, C, Kaye, R, Swift, W, Botten, N, Serhan, CN, and Dartt, DA. "Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model." Mucosal Immunology (October 2, 2018).  Full Text
    • Saban, DR. "New concepts in macrophage ontogeny in the adult neural retina." Cellular Immunology 330 (August 2018): 79-85.  Full Text
    • Reyes, NJ, Yu, C, Mathew, R, Kunnen, CM, Kalnitsky, J, Redfern, RL, Leonardi, A, Perez, VL, MacLeod, AS, Gupta, PK, and Saban, DR. "Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice." Science Translational Medicine 10, no. 451 (July 2018).  Full Text
    • Pastak, M, Kleff, V, Saban, DR, Czugala, M, Steuhl, K-P, Ergün, S, Singer, BB, and Fuchsluger, TA. "Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation." Human Gene Therapy 29, no. 4 (April 2018): 467-479.  Full Text
    • Toomey, CB, Landowski, M, Klingeborn, M, Kelly, U, Deans, J, Dong, H, Harrabi, O, Van Blarcom, T, Yeung, YA, Grishanin, R, Lin, JC, Saban, DR, and Bowes Rickman, C. "Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science 59, no. 2 (February 2018): 662-673.  Full Text
    • Reyes, NJ, Mathew, R, and Saban, DR. "Induction and Characterization of the Allergic Eye Disease Mouse Model." Methods in Molecular Biology (Clifton, N.J.) 1799 (January 2018): 49-57.  Full Text
    • Hammer, SS, Beli, E, Kady, N, Wang, Q, Wood, K, Lydic, TA, Malek, G, Saban, DR, Wang, XX, Hazra, S, Levi, M, Busik, JV, and Grant, MB. "The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor." Ebiomedicine 22 (August 2017): 181-190.  Full Text
    • Reyes, NJ, and Saban, DR. "A Commencement for Eye Commensals." Immunity 47, no. 1 (July 2017): 6-8.  Full Text
    • Beli, E, Dominguez, JM, Hu, P, Thinschmidt, JS, Caballero, S, Calzi, SL, Luo, D, Shanmugam, S, Salazar, TE, Duan, Y, Boulton, ME, Mohr, S, Abcouwer, SF, Saban, DR, Harrison, JK, and Grant, MB. "Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes." Journal of molecular medicine (Berlin, Germany) 95, no. 5 (May 2017): 565-566.  Full Text
    • Reyes, NJ, O'Koren, EG, and Saban, DR. "New insights into mononuclear phagocyte biology from the visual system." Nature Reviews. Immunology 17, no. 5 (May 2017): 322-332. (Review)  Full Text
    • Beli, E, Dominguez, JM, Hu, P, Thinschmidt, JS, Caballero, S, Li Calzi, S, Luo, D, Shanmugam, S, Salazar, TE, Duan, Y, Boulton, ME, Mohr, S, Abcouwer, SF, Saban, DR, Harrison, JK, and Grant, MB. "CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes." Journal of molecular medicine (Berlin, Germany) 94, no. 11 (November 2016): 1255-1265.  Full Text
    • McNabb, RP, Blanco, T, Bomze, HM, Tseng, HC, Saban, DR, Izatt, JA, and Kuo, AN. "Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice." Experimental Eye Research 151 (October 2016): 68-74.  Full Text
    • Ahadome, SD, Abraham, DJ, Rayapureddi, S, Saw, VP, Saban, DR, Calder, VL, Norman, JT, Ponticos, M, Daniels, JT, and Dart, JK. "Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring." Jci Insight 1, no. 12 (August 4, 2016): e87001-null.  Full Text
    • Ahadome, SD, Mathew, R, Reyes, NJ, Mettu, PS, Cousins, SW, Calder, VL, and Saban, DR. "Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy." JCI insight 1, no. 12 (August 2016).  Full Text
    • Smith, RE, Reyes, NJ, Khandelwal, P, Schlereth, SL, Lee, HS, Masli, S, and Saban, DR. "Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease." Journal of Leukocyte Biology 100, no. 2 (August 2016): 371-380.  Full Text
    • O'Koren, EG, Mathew, R, and Saban, DR. "Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina." Scientific Reports 6 (February 9, 2016): 20636-null.  Full Text
    • Pajoohesh-Ganji, A, Pal-Ghosh, S, Tadvalkar, G, Kyne, BM, Saban, DR, and Stepp, MA. "Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea." Laboratory investigation; a journal of technical methods and pathology 95, no. 11 (November 2015): 1305-1318.  Full Text
    • Dale, SB, and Saban, DR. "Linking immune responses with fibrosis in allergic eye disease." Current Opinion in Allergy and Clinical Immunology 15, no. 5 (October 2015): 467-475. (Review)  Full Text
    • Saban, D. "Immune Responses at the Ocular Surface." Acta Ophthalmologica 93 (October 2015): n/a-n/a.  Full Text
    • Toomey, CB, Kelly, U, Saban, DR, and Bowes Rickman, C. "Regulation of age-related macular degeneration-like pathology by complement factor H." Proceedings of the National Academy of Sciences of the United States of America 112, no. 23 (June 2015): E3040-E3049.  Full Text
    • Lee, H-S, Hos, D, Blanco, T, Bock, F, Reyes, NJ, Mathew, R, Cursiefen, C, Dana, R, and Saban, DR. "Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease." Investigative Ophthalmology & Visual Science 56, no. 5 (May 2015): 3140-3148.  Full Text
    • Reyes, NJ, and Saban, DR. "T helper subsets in allergic eye disease." Current Opinion in Allergy and Clinical Immunology 14, no. 5 (October 2014): 477-484. (Review)  Full Text
    • Kodati, S, Chauhan, SK, Chen, Y, Dohlman, TH, Karimian, P, Saban, D, and Dana, R. "CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease." Investigative ophthalmology & visual science 55, no. 9 (August 19, 2014): 5871-5877.  Full Text
    • Pal-Ghosh, S, Pajoohesh-Ganji, A, Menko, AS, Oh, H-Y, Tadvalkar, G, Saban, DR, and Stepp, MA. "Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury." Investigative ophthalmology & visual science 55, no. 4 (April 28, 2014): 2757-2765.  Full Text
    • Saban, DR. "The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation." The ocular surface 12, no. 2 (April 2014): 87-99. (Review)  Full Text
    • Chauhan, SK, Saban, DR, Dohlman, TH, and Dana, R. "CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue." J Immunol 192, no. 2 (January 15, 2014): 817-823.  Full Text  Link to Item
    • Chen, Y, Chauhan, SK, Lee, HS, Saban, DR, and Dana, R. "Chronic dry eye disease is principally mediated by effector memory Th17 cells." Mucosal Immunology 7, no. 1 (January 2014): 38-45.  Full Text
    • Hu, P, Thinschmidt, JS, Yan, Y, Hazra, S, Bhatwadekar, A, Caballero, S, Salazar, T, Miyan, JA, Li, W, Derbenev, A, Zsombok, A, Tikhonenko, M, Dominguez, JM, McGorray, SP, Saban, DR, Boulton, ME, Busik, JV, Raizada, MK, Chan-Ling, T, and Grant, MB. "CNS inflammation and bone marrow neuropathy in type 1 diabetes." The American Journal of Pathology 183, no. 5 (November 2013): 1608-1620.  Full Text
    • Chen, Y, Chauhan, SK, Lee, HS, Stevenson, W, Schaumburg, CS, Sadrai, Z, Saban, DR, Kodati, S, Stern, ME, and Dana, R. "Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. (Published online)" Invest Ophthalmol Vis Sci 54, no. 4 (April 3, 2013): 2457-2464.  Full Text  Link to Item
    • Hazra, S, Jarajapu, YPR, Stepps, V, Caballero, S, Thinschmidt, JS, Sautina, L, Bengtsson, N, Licalzi, S, Dominguez, J, Kern, TS, Segal, MS, Ash, JD, Saban, DR, Bartelmez, SH, and Grant, MB. "Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model." Diabetologia 56, no. 3 (March 2013): 644-653.  Full Text
    • Saban, DR, Calder, V, Kuo, C-H, Reyes, NJ, Dartt, DA, Ono, SJ, and Niederkorn, JY. "New twists to an old story: novel concepts in the pathogenesis of allergic eye disease." Curr Eye Res 38, no. 3 (March 2013): 317-330. (Review)  Full Text  Link to Item
    • Khandelwal, P, Blanco-Mezquita, T, Emami, P, Lee, HS, Reyes, NJ, Mathew, R, Huang, R, and Saban, DR. "Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses." Plos One 8, no. 5 (January 2013): e64193-null.  Full Text
    • Lee, HS, Schlereth, S, Khandelwal, P, and Saban, DR. "Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process." Plos One 8, no. 9 (January 2013): e75769-null.  Full Text
    • Stevenson, W, Cheng, S-F, Emami-Naeini, P, Hua, J, Paschalis, EI, Dana, R, and Saban, DR. "Gamma-irradiation reduces the allogenicity of donor corneas. (Published online)" Invest Ophthalmol Vis Sci 53, no. 11 (October 1, 2012): 7151-7158.  Full Text  Link to Item
    • Bhatwadekar, AD, Hu, P, Hazra, S, Caballero, S, Mohr, S-S, Abcouwer, SF, Saban, DR, Chan-Ling, T, Busik, JV, and Grant, MB. "Decreased Bone Marrow Neuronal Support in Type 1 Diabetes Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 (CCR2) Monocytes." DIABETES 61 (June 1, 2012): A69-A69.  Link to Item
    • Schlereth, S, Lee, HS, Khandelwal, P, and Saban, DR. "Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis." The American Journal of Pathology 180, no. 6 (June 2012): 2351-2360.  Full Text
    • Hattori, T, Saban, DR, Emami-Naeini, P, Chauhan, SK, Funaki, T, Ueno, H, and Dana, R. "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation." J Leukoc Biol 91, no. 4 (April 2012): 621-627.  Full Text  Link to Item
    • Ueno, H, Ferrari, G, Hattori, T, Saban, DR, Katikireddy, KR, Chauhan, SK, and Dana, R. "Dependence of corneal stem/progenitor cells on ocular surface innervation." Investigative Ophthalmology & Visual Science 53, no. 2 (February 21, 2012): 867-872.  Full Text
    • Dastjerdi, MH, Sadrai, Z, Saban, DR, Zhang, Q, and Dana, R. "Corneal penetration of topical and subconjunctival bevacizumab. (Published online)" Invest Ophthalmol Vis Sci 52, no. 12 (November 7, 2011): 8718-8723.  Full Text  Link to Item
    • Hattori, T, Chauhan, SK, Lee, H, Ueno, H, Dana, R, Kaplan, DH, and Saban, DR. "Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. (Published online)" Invest Ophthalmol Vis Sci 52, no. 7 (June 28, 2011): 4598-4604.  Full Text  Link to Item
    • Chen, Y, Chauhan, SK, Saban, DR, Sadrai, Z, Okanobo, A, and Dana, R. "Interferon-γ-secreting NK cells promote induction of dry eye disease." J Leukoc Biol 89, no. 6 (June 2011): 965-972.  Full Text  Link to Item
    • Sadrai, Z, Hajrasouliha, AR, Chauhan, S, Saban, DR, Dastjerdi, MH, and Dana, R. "Effect of topical azithromycin on corneal innate immune responses. (Published online)" Invest Ophthalmol Vis Sci 52, no. 5 (April 19, 2011): 2525-2531.  Full Text  Link to Item
    • Hos, D, Saban, DR, Bock, F, Regenfuss, B, Onderka, J, Masli, S, and Cursiefen, C. "Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids." Archives of Ophthalmology (Chicago, Ill. : 1960) 129, no. 4 (April 2011): 445-452.  Full Text
    • Cursiefen, C, Maruyama, K, Bock, F, Saban, D, Sadrai, Z, Lawler, J, Dana, R, and Masli, S. "Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes." Journal of Experimental Medicine 208, no. 5 (2011): 1083-1092.  Full Text
    • Vega, JL, Saban, D, Carrier, Y, Masli, S, and Weiner, HL. "Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β." Ocular Immunology and Inflammation 18, no. 6 (December 2010): 459-469.  Full Text
    • Saban, DR, Bock, F, Chauhan, SK, Masli, S, and Dana, R. "Thrombospondin-1 derived from APCs regulates their capacity for allosensitization." J Immunol 185, no. 8 (October 15, 2010): 4691-4697.  Full Text  Link to Item
    • Dastjerdi, MH, Saban, DR, Okanobo, A, Nallasamy, N, Sadrai, Z, Chauhan, SK, Hajrasouliha, AR, and Dana, R. "Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival." Invest Ophthalmol Vis Sci 51, no. 5 (May 2010): 2411-2417.  Full Text  Link to Item
    • Jin, Y, Chauhan, SK, Saban, DR, and Dana, R. "Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation." Invest Ophthalmol Vis Sci 51, no. 2 (February 2010): 816-821.  Full Text  Link to Item
    • Jin, Y, Arita, M, Zhang, Q, Saban, DR, Chauhan, SK, Chiang, N, Serhan, CN, and Dana, R. "Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators." Investigative Ophthalmology & Visual Science 50, no. 10 (October 2009): 4743-4752.  Full Text
    • El Annan, J, Chauhan, SK, Ecoiffier, T, Zhang, Q, Saban, DR, and Dana, R. "Characterization of effector T cells in dry eye disease." Invest Ophthalmol Vis Sci 50, no. 8 (August 2009): 3802-3807.  Full Text  Link to Item
    • Zhang, X, Shen, L, Jin, Y, Saban, DR, Chauhan, SK, and Dana, R. "Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?." Invest Ophthalmol Vis Sci 50, no. 7 (July 2009): 3137-3144.  Full Text  Link to Item
    • Chung, E-S, Saban, DR, Chauhan, SK, and Dana, R. "Regulation of blood vessel versus lymphatic vessel growth in the cornea." Invest Ophthalmol Vis Sci 50, no. 4 (April 2009): 1613-1618.  Full Text  Link to Item
    • Saban, DR, Chauhan, SK, Zhang, X, El Annan, J, Jin, Y, and Dana, R. "'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival." Am J Transplant 9, no. 3 (March 2009): 473-482.  Full Text  Link to Item
    • Chauhan, SK, El Annan, J, Ecoiffier, T, Goyal, S, Zhang, Q, Saban, DR, and Dana, R. "Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression." Journal of Immunology (Baltimore, Md. : 1950) 182, no. 3 (February 2009): 1247-1252.  Full Text
    • Chauhan, SK, Saban, DR, Lee, HK, and Dana, R. "Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation." Journal of Immunology (Baltimore, Md. : 1950) 182, no. 1 (January 2009): 148-153.  Full Text
    • Saban, DR, Elder, IA, Nguyen, CQ, Smith, WC, Timmers, AM, Grant, MB, and Peck, AB. "Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. (Published online)" Mol Vis 14 (March 26, 2008): 615-624.  Link to Item
    • Saban, DR, Cornelius, J, Masli, S, Schwartzkopff, J, Doyle, M, Chauhan, SK, Peck, AB, and Grant, MB. "The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens." Mol Vis 14 (2008): 2435-2442.  Link to Item
    • Doyle, ME, Boggs, L, Attia, R, Cooper, LR, Saban, DR, Nguyen, CQ, and Peck, AB. "Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition." The American Journal of Pathology 171, no. 4 (October 2007): 1224-1236.  Full Text
    • Nguyen, CQ, Gao, J-H, Kim, H, Saban, DR, Cornelius, JG, and Peck, AB. "IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse." Journal of Immunology (Baltimore, Md. : 1950) 179, no. 1 (July 2007): 382-390.  Full Text
    • Sengupta, N, Caballero, S, Mames, RN, Timmers, AM, Saban, D, and Grant, MB. "Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors." Investigative Ophthalmology & Visual Science 46, no. 1 (January 2005): 343-348.  Full Text

  • Other Articles

    • Blanco, T, and Saban, DR. "The cornea has "the nerve" to encourage immune rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 6 (June 2015): 1453-1454.  Full Text

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