Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Investigator, Immunology, Schepens Eye Research Institute, Harvard Medical School 2009 - 2012
  • Instructor, Ophthalmology, Harvard Medical School 2010 - 2012
  • Research Fellow, Schepens Eye Research Instittute, Harvard Medical School 2006 - 2009
  • Ph.D., University of Florida 2005
  • M.S., University of Florida 2002
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Immunology, Immunology, Basic Science Departments 2012 - 2021
  • Associate Professor of Ophthalmology, Ophthalmology, Corneal Diseases, Ophthalmology 2017 - 2020
  • Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2012 - 2017
  • Instructor in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2012
• Recognition
• 

  In the News

  • APR 19, 2021

    Duke Health News

    Duke-Led Team Finds Why Women May Be Better Equipped to Fight COVID
• Research
• 

  Selected Grants

  • Immune Mechanisms in Ocular Graft versus Host Disease awarded by National Institutes of Health 2018 - 2026
  • Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis awarded by National Institutes of Health 2021 - 2026
  • Gut-brain dysfunction following combined prenatal stressors: relevance for autism awarded by National Institutes of Health 2021 - 2026
  • Role of Tissue Resident Macrophages in the Conventional Outflow Function awarded by National Institutes of Health 2021 - 2025
  • Basic Immunology Training Program awarded by National Institutes of Health 2002 - 2025
  • TRPM8 in eye health and disease awarded by National Institutes of Health 2020 - 2024
  • Cellular and Molecular Dynamics of Retinal Microglial in the Context of Photoreceptor Degeneration awarded by National Institutes of Health 2020 - 2024
  • Understanding the roles of ectosomes and the associated microglial response in photoreceptor degeneration 2021 - 2022
  • Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2022
  • Cellular and Molecular Mechanisms that Contribute to Ocular Surface Disease during Severe Allergic Inflammation awarded by National Institutes of Health 2012 - 2022
  • Local regulation and deletion of T cells to induce tolerance and establish long-term survival of high-risk corneal transplants awarded by University of Miami 2020 - 2022
  • Macrophage-Nerve Interactions in Neurotrophic Keratitis 2020 - 2021
  • Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution awarded by Schepens Eye Research Institute 2019 - 2021
  • The Role of Macrophages in Conventional Outflow Homeostasis awarded by American Glaucoma Society 2020 - 2021
  • Immunophenotyping the effect of Xiidra treatment in the inflammatory dry eye disease setting with underlying meibomian gland dysfunction 2018 - 2020
  • Dompe IIR 2019 - 2020
  • Innate immunity, lipoproteins and AMD progression awarded by National Institutes of Health 2016 - 2019
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by University of Alabama at Birmingham 2017 - 2019
  • Monocytes in Dry Age-Related Macular Degeneration awarded by National Institutes of Health 2016 - 2019
  • Role of bona fide microglia in retinal degeneration 2017 - 2019
  • RPB: 2014 Nelson Trust Award 2014 - 2019
  • Evaluation of the effects of topically administered IL-17 antagonist compound on ocular allergy parameters in the severe allergic eye disease (AED) mouse model 2016 - 2019
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution awarded by Schepens Eye Research Institute 2014 - 2018
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases 2017 - 2018
  • The role of a macrophage chemotactic factor in AMD 2015 - 2017
  • Examining the role of IFN-g+IL-17+ pathogenic Th17 cells in severe ocular allergy awarded by National Institutes of Health 2015 - 2017
  • LXR as a novel therapeutic target in diabetic retinopathy 2015 - 2017
  • Macrophages Drive Neovascular Remodeling in NVAMD 2014 - 2016
  • Bone marrow neuropathy drives diabetic retinopathy 2013 - 2016
  • Neuroinflammation: the role of lymphocytes in glaucoma 2014 - 2016
  • Molecular Mechanisms of Corneal Recurrent Erosion Formation awarded by The George Washington University 2013 - 2015
• 

  External Relationships

  • Aerie Pharmaceuticals, Inc.
  • Roche
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wolff, Daniel, Vedran Radojcic, Robert Lafyatis, Resat Cinar, Rachel K. Rosenstein, Edward W. Cowen, Guang-Shing Cheng, et al. “National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.” Transplant Cell Ther 27, no. 10 (October 2021): 817–35. https://doi.org/10.1016/j.jtct.2021.06.001.
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    • Singh, Pali P., Chen Yu, Rose Mathew, Victor L. Perez, and Daniel R. Saban. “Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model.” Ocul Surf 21 (July 2021): 271–78. https://doi.org/10.1016/j.jtos.2021.03.009.
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    • Jia, Wei, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, et al. “BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.” Blood 137, no. 18 (May 6, 2021): 2544–57. https://doi.org/10.1182/blood.2020008040.
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    • Qian, Ruobing, Ryan P. McNabb, Kevin C. Zhou, Hazem M. Mousa, Daniel R. Saban, Victor L. Perez, Anthony N. Kuo, and Joseph A. Izatt. “In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography.” Biomed Opt Express 12, no. 4 (April 1, 2021): 2134–48. https://doi.org/10.1364/BOE.419063.
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    • Mousa, Hazem M., Daniel R. Saban, and Victor L. Perez. “The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology.” Exp Eye Res 205 (April 2021): 108502. https://doi.org/10.1016/j.exer.2021.108502.
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    • McClain, Micah T., Florica J. Constantine, Ricardo Henao, Yiling Liu, Ephraim L. Tsalik, Thomas W. Burke, Julie M. Steinbrink, et al. “Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.” Nat Commun 12, no. 1 (February 17, 2021): 1079. https://doi.org/10.1038/s41467-021-21289-y.
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    • Steven, Philipp, Sebastian Schwab, Anne Kiesewetter, Daniel R. Saban, Michael E. Stern, and Uta Gehlsen. “Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy.” Int J Mol Sci 21, no. 20 (October 12, 2020). https://doi.org/10.3390/ijms21207514.
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    • Yu, Chen, Christophe Roubeix, Florian Sennlaub, and Daniel R. Saban. “Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina.” Trends Neurosci 43, no. 6 (June 2020): 433–49. https://doi.org/10.1016/j.tins.2020.03.012.
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    • Periman, Laura M., Victor L. Perez, Daniel R. Saban, Meng C. Lin, and Piergiorgio Neri. “The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.” J Ocul Pharmacol Ther 36, no. 3 (April 2020): 137–46. https://doi.org/10.1089/jop.2019.0060.
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    • Lu, Xiaoxiao, Abirami Kugadas, Kirsten Smith-Page, Jeffrey Lamb, Tiffany Lin, Yusha Ru, Sharon Celeste Morley, et al. “Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.” Front Immunol 11 (2020): 547. https://doi.org/10.3389/fimmu.2020.00547.
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    • Puñal, Vanessa M., Caitlin E. Paisley, Federica S. Brecha, Monica A. Lee, Robin M. Perelli, Jingjing Wang, Emily G. O’Koren, et al. “Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.” Plos Biol 17, no. 10 (October 2019): e3000492. https://doi.org/10.1371/journal.pbio.3000492.
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    • Royer, Derek J., Jose Echegaray-Mendez, Liwen Lin, Grzegorz B. Gmyrek, Rose Mathew, Daniel R. Saban, Victor L. Perez, and Daniel Jj Carr. “Complement and CD4+ T cells drive context-specific corneal sensory neuropathy.” Elife 8 (August 15, 2019). https://doi.org/10.7554/eLife.48378.
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    • Spencer, William J., Jin-Dong Ding, Tylor R. Lewis, Chen Yu, Sebastien Phan, Jillian N. Pearring, Keun-Young Kim, et al. “PRCD is essential for high-fidelity photoreceptor disc formation.” Proc Natl Acad Sci U S A 116, no. 26 (June 25, 2019): 13087–96. https://doi.org/10.1073/pnas.1906421116.
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    • McMenamin, Paul G., Daniel R. Saban, and Samantha J. Dando. “Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.” Prog Retin Eye Res 70 (May 2019): 85–98. https://doi.org/10.1016/j.preteyeres.2018.12.002.
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    • O’Koren, Emily G., Chen Yu, Mikael Klingeborn, Alicia Y. W. Wong, Cameron L. Prigge, Rose Mathew, Joan Kalnitsky, et al. “Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.” Immunity 50, no. 3 (March 19, 2019): 723-737.e7. https://doi.org/10.1016/j.immuni.2019.02.007.
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    • Reyes, Nancy J., Rose Mathew, and Daniel R. Saban. “Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease.” Methods Mol Biol 1834 (2019): 153–64. https://doi.org/10.1007/978-1-4939-8669-9_11.
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    • Saban, Daniel R., Robin R. Hodges, Rose Mathew, Nancy J. Reyes, Chen Yu, Rebecca Kaye, William Swift, Nora Botten, Charles N. Serhan, and Darlene A. Dartt. “Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.” Mucosal Immunol 12, no. 1 (January 2019): 145–53. https://doi.org/10.1038/s41385-018-0089-1.
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    • Yu, Chen, and Daniel R. Saban. “Identification of a Unique Subretinal Microglia Type in Retinal Degeneration Using Single Cell RNA-Seq.” Adv Exp Med Biol 1185 (2019): 181–86. https://doi.org/10.1007/978-3-030-27378-1_30.
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    • Poe, Jonathan C., Wei Jia, Julie A. Di Paolo, Nancy J. Reyes, Ji Yun Kim, Hsuan Su, John S. Sundy, et al. “SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.” Jci Insight 3, no. 19 (October 4, 2018). https://doi.org/10.1172/jci.insight.122430.
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    • Saban, Daniel R. “New concepts in macrophage ontogeny in the adult neural retina.” Cell Immunol 330 (August 2018): 79–85. https://doi.org/10.1016/j.cellimm.2018.04.008.
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    • Reyes, Nancy J., Chen Yu, Rose Mathew, Carolina M. Kunnen, Joan Kalnitsky, Rachel L. Redfern, Andrea Leonardi, et al. “Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.” Sci Transl Med 10, no. 451 (July 25, 2018). https://doi.org/10.1126/scitranslmed.aas9164.
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    • Pastak, Marko, Veronika Kleff, Daniel R. Saban, Marta Czugala, Klaus-Peter Steuhl, Süleyman Ergün, Bernhard B. Singer, and Thomas A. Fuchsluger. “Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation.” Hum Gene Ther 29, no. 4 (April 2018): 467–79. https://doi.org/10.1089/hum.2017.044.
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    • Toomey, Christopher B., Michael Landowski, Mikael Klingeborn, Una Kelly, John Deans, Holly Dong, Ons Harrabi, et al. “Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.” Invest Ophthalmol Vis Sci 59, no. 2 (February 1, 2018): 662–73. https://doi.org/10.1167/iovs.17-23134.
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    • Kodati, Shilpa, Sunil K. Chauhan, Yihe Chen, Parisa Emami-Naeini, Masahiro Omoto, Thomas H. Dohlman, William Stevenson, et al. “Interleukin-6 neutralization prolongs corneal allograft survival.” Curr Trends Immunol 19 (2018): 105–13.
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    • Reyes, Nancy J., Rose Mathew, and Daniel R. Saban. “Induction and Characterization of the Allergic Eye Disease Mouse Model.” Methods Mol Biol 1799 (2018): 49–57. https://doi.org/10.1007/978-1-4939-7896-0_5.
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    • Hammer, Sandra S., Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A. Lydic, Goldis Malek, et al. “The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor.” Ebiomedicine 22 (August 2017): 181–90. https://doi.org/10.1016/j.ebiom.2017.07.008.
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    • Reyes, Nancy J., and Daniel R. Saban. “A Commencement for Eye Commensals.” Immunity 47, no. 1 (July 18, 2017): 6–8. https://doi.org/10.1016/j.immuni.2017.07.006.
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    • Beli, Eleni, James M. Dominguez, Ping Hu, Jeffrey S. Thinschmidt, Sergio Caballero, Sergio Li Calzi, Defang Luo, et al. “Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.” J Mol Med (Berl) 95, no. 5 (May 2017): 565–66. https://doi.org/10.1007/s00109-017-1530-8.
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    • Reyes, Nancy J., Emily G. O’Koren, and Daniel R. Saban. “New insights into mononuclear phagocyte biology from the visual system.” Nat Rev Immunol 17, no. 5 (May 2017): 322–32. https://doi.org/10.1038/nri.2017.13.
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    • Beli, Eleni, James M. Dominguez, Ping Hu, Jeffrey S. Thinschmidt, Sergio Caballero, Sergio Li Calzi, Defang Luo, et al. “CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes.” J Mol Med (Berl) 94, no. 11 (November 2016): 1255–65. https://doi.org/10.1007/s00109-016-1433-0.
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    • McNabb, Ryan P., Tomas Blanco, Howard M. Bomze, Henry C. Tseng, Daniel R. Saban, Joseph A. Izatt, and Anthony N. Kuo. “Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.” Exp Eye Res 151 (October 2016): 68–74. https://doi.org/10.1016/j.exer.2016.08.003.
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    • Ahadome, Sarah D., David J. Abraham, Suryanarayana Rayapureddi, Valerie P. Saw, Daniel R. Saban, Virginia L. Calder, Jill T. Norman, Markella Ponticos, Julie T. Daniels, and John K. Dart. “Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.” Jci Insight 1, no. 12 (August 4, 2016): e87001. https://doi.org/10.1172/jci.insight.87001.
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    • Ahadome, Sarah D., Rose Mathew, Nancy J. Reyes, Priyatham S. Mettu, Scott W. Cousins, Virginia L. Calder, and Daniel R. Saban. “Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy.” Jci Insight 1, no. 12 (August 4, 2016). https://doi.org/10.1172/jci.insight.87012.
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    • Smith, R. E., N. J. Reyes, P. Khandelwal, S. L. Schlereth, H. S. Lee, S. Masli, and D. R. Saban. “Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease.” J Leukoc Biol 100, no. 2 (August 2016): 371–80. https://doi.org/10.1189/jlb.3A0815-357RR.
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    • O’Koren, E. G., R. Mathew, and D. R. Saban. “Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina.” Sci Rep 6 (February 9, 2016): 20636. https://doi.org/10.1038/srep20636.
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    • Pajoohesh-Ganji, Ahdeah, Sonali Pal-Ghosh, Gauri Tadvalkar, Briana M. Kyne, Daniel R. Saban, and Mary Ann Stepp. “Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea.” Lab Invest 95, no. 11 (November 2015): 1305–18. https://doi.org/10.1038/labinvest.2015.113.
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    • Dale, Sarah B., and Daniel R. Saban. “Linking immune responses with fibrosis in allergic eye disease.” Curr Opin Allergy Clin Immunol 15, no. 5 (October 2015): 467–75. https://doi.org/10.1097/ACI.0000000000000197.
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    • Saban, D. R. “Immune Responses at the Ocular Surface.” Acta Ophthalmologica 93 (October 2015): n/a-n/a. https://doi.org/10.1111/j.1755-3768.2015.0583.
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    • Toomey, Christopher B., Una Kelly, Daniel R. Saban, and Catherine Bowes Rickman. “Regulation of age-related macular degeneration-like pathology by complement factor H.” Proc Natl Acad Sci U S A 112, no. 23 (June 9, 2015): E3040–49. https://doi.org/10.1073/pnas.1424391112.
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    • Lee, Hyun-Soo, Deniz Hos, Tomas Blanco, Felix Bock, Nancy J. Reyes, Rose Mathew, Claus Cursiefen, Reza Dana, and Daniel R. Saban. “Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease.” Invest Ophthalmol Vis Sci 56, no. 5 (May 2015): 3140–48. https://doi.org/10.1167/iovs.14-16186.
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    • Reyes, Nancy J., and Daniel R. Saban. “T helper subsets in allergic eye disease.” Curr Opin Allergy Clin Immunol 14, no. 5 (October 2014): 477–84. https://doi.org/10.1097/ACI.0000000000000088.
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    • Kodati, Shilpa, Sunil K. Chauhan, Yihe Chen, Thomas H. Dohlman, Parisa Karimian, Daniel Saban, and Reza Dana. “CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease.” Invest Ophthalmol Vis Sci 55, no. 9 (August 19, 2014): 5871–77. https://doi.org/10.1167/iovs.14-14481.
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    • Pal-Ghosh, Sonali, Ahdeah Pajoohesh-Ganji, A Sue Menko, Hye-young Oh, Gauri Tadvalkar, Daniel R. Saban, and Mary Ann Stepp. “Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury.” Invest Ophthalmol Vis Sci 55, no. 4 (April 28, 2014): 2757–65. https://doi.org/10.1167/iovs.13-13557.
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    • Saban, Daniel R. “The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation.” Ocul Surf 12, no. 2 (April 2014): 87–99. https://doi.org/10.1016/j.jtos.2013.10.007.
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    • Chauhan, Sunil K., Daniel R. Saban, Thomas H. Dohlman, and Reza Dana. “CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue.” J Immunol 192, no. 2 (January 15, 2014): 817–23. https://doi.org/10.4049/jimmunol.1203469.
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    • Chen, Y., S. K. Chauhan, H Soo Lee, D. R. Saban, and R. Dana. “Chronic dry eye disease is principally mediated by effector memory Th17 cells.” Mucosal Immunol 7, no. 1 (January 2014): 38–45. https://doi.org/10.1038/mi.2013.20.
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    • Hu, Ping, Jeffrey S. Thinschmidt, Yuanqing Yan, Sugata Hazra, Ashay Bhatwadekar, Sergio Caballero, Tatiana Salazar, et al. “CNS inflammation and bone marrow neuropathy in type 1 diabetes.” Am J Pathol 183, no. 5 (November 2013): 1608–20. https://doi.org/10.1016/j.ajpath.2013.07.009.
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    • Chen, Yihe, Sunil K. Chauhan, Hyun Soo Lee, William Stevenson, Chris S. Schaumburg, Zahra Sadrai, Daniel R. Saban, Shilpa Kodati, Michael E. Stern, and Reza Dana. “Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis.” Invest Ophthalmol Vis Sci 54, no. 4 (April 3, 2013): 2457–64. https://doi.org/10.1167/iovs.12-11121.
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    • Hazra, S., Y. P. R. Jarajapu, V. Stepps, S. Caballero, J. S. Thinschmidt, L. Sautina, N. Bengtsson, et al. “Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.” Diabetologia 56, no. 3 (March 2013): 644–53. https://doi.org/10.1007/s00125-012-2781-0.
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    • Saban, Daniel R., Virginia Calder, Chuan-Hui Kuo, Nancy J. Reyes, Darlene A. Dartt, Santa J. Ono, and Jerry Y. Niederkorn. “New twists to an old story: novel concepts in the pathogenesis of allergic eye disease.” Curr Eye Res 38, no. 3 (March 2013): 317–30. https://doi.org/10.3109/02713683.2012.747617.
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    • Khandelwal, Payal, Tomas Blanco-Mezquita, Parisa Emami, Hyun Soo Lee, Nancy J. Reyes, Rose Mathew, Randy Huang, and Daniel R. Saban. “Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses.” Plos One 8, no. 5 (2013): e64193. https://doi.org/10.1371/journal.pone.0064193.
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    • Lee, Hyun Soo, Simona Schlereth, Payal Khandelwal, and Daniel R. Saban. “Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process.” Plos One 8, no. 9 (2013): e75769. https://doi.org/10.1371/journal.pone.0075769.
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    • Stevenson, William, Sheng-Fu Cheng, Parisa Emami-Naeini, Jing Hua, Eleftherios I. Paschalis, Reza Dana, and Daniel R. Saban. “Gamma-irradiation reduces the allogenicity of donor corneas.” Invest Ophthalmol Vis Sci 53, no. 11 (October 1, 2012): 7151–58. https://doi.org/10.1167/iovs.12-9609.
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    • Bhatwadekar, Ashay D., Ping Hu, Sugata Hazra, Sergio Caballero, Su-Sanne Mohr, Steven F. Abcouwer, Daniel R. Saban, Tailoi Chan-Ling, Julia V. Busik, and Maria B. Grant. “Decreased Bone Marrow Neuronal Support in Type 1 Diabetes Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 (CCR2) Monocytes.” Diabetes 61 (June 1, 2012): A69–A69.
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    • Schlereth, Simona, Hyun Soo Lee, Payal Khandelwal, and Daniel R. Saban. “Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.” Am J Pathol 180, no. 6 (June 2012): 2351–60. https://doi.org/10.1016/j.ajpath.2012.02.015.
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    • Hattori, Takaaki, Daniel R. Saban, Parisa Emami-Naeini, Sunil K. Chauhan, Toshinari Funaki, Hiroki Ueno, and Reza Dana. “Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation.” J Leukoc Biol 91, no. 4 (April 2012): 621–27. https://doi.org/10.1189/jlb.1011500.
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    • Ueno, Hiroki, Giulio Ferrari, Takaaki Hattori, Daniel R. Saban, Kishore R. Katikireddy, Sunil K. Chauhan, and Reza Dana. “Dependence of corneal stem/progenitor cells on ocular surface innervation.” Invest Ophthalmol Vis Sci 53, no. 2 (February 21, 2012): 867–72. https://doi.org/10.1167/iovs.11-8438.
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    • Dastjerdi, Mohammad H., Zahra Sadrai, Daniel R. Saban, Qiang Zhang, and Reza Dana. “Corneal penetration of topical and subconjunctival bevacizumab.” Invest Ophthalmol Vis Sci 52, no. 12 (November 7, 2011): 8718–23. https://doi.org/10.1167/iovs.11-7871.
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    • Hattori, Takaaki, Sunil K. Chauhan, Hyunsoo Lee, Hiroki Ueno, Reza Dana, Daniel H. Kaplan, and Daniel R. Saban. “Characterization of Langerin-expressing dendritic cell subsets in the normal cornea.” Invest Ophthalmol Vis Sci 52, no. 7 (June 28, 2011): 4598–4604. https://doi.org/10.1167/iovs.10-6741.
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    • Chen, Yihe, Sunil K. Chauhan, Daniel R. Saban, Zahra Sadrai, Andre Okanobo, and Reza Dana. “Interferon-γ-secreting NK cells promote induction of dry eye disease.” J Leukoc Biol 89, no. 6 (June 2011): 965–72. https://doi.org/10.1189/jlb.1110611.
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    • Cursiefen, Claus, Kazuichi Maruyama, Felix Bock, Daniel Saban, Zahra Sadrai, Jack Lawler, Reza Dana, and Sharmila Masli. “Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.” J Exp Med 208, no. 5 (May 9, 2011): 1083–92. https://doi.org/10.1084/jem.20092277.
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    • Sadrai, Zahra, Amir Reza Hajrasouliha, Sunil Chauhan, Daniel R. Saban, Mohammad H. Dastjerdi, and Reza Dana. “Effect of topical azithromycin on corneal innate immune responses.” Invest Ophthalmol Vis Sci 52, no. 5 (April 19, 2011): 2525–31. https://doi.org/10.1167/iovs.10-5658.
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    • Hos, Deniz, Daniel R. Saban, Felix Bock, Birgit Regenfuss, Jasmine Onderka, Sharmila Masli, and Claus Cursiefen. “Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.” Arch Ophthalmol 129, no. 4 (April 2011): 445–52. https://doi.org/10.1001/archophthalmol.2011.42.
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    • Vega, Jose L., Daniel Saban, Yejun Carrier, Sharmila Masli, and Howard L. Weiner. “Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.” Ocul Immunol Inflamm 18, no. 6 (December 2010): 459–69. https://doi.org/10.3109/09273948.2010.509532.
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    • Saban, Daniel R., Felix Bock, Sunil K. Chauhan, Sharmila Masli, and Reza Dana. “Thrombospondin-1 derived from APCs regulates their capacity for allosensitization.” J Immunol 185, no. 8 (October 15, 2010): 4691–97. https://doi.org/10.4049/jimmunol.1001133.
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    • Dastjerdi, Mohammad H., Daniel R. Saban, Andre Okanobo, Nambi Nallasamy, Zahra Sadrai, Sunil K. Chauhan, Amir R. Hajrasouliha, and Reza Dana. “Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival.” Invest Ophthalmol Vis Sci 51, no. 5 (May 2010): 2411–17. https://doi.org/10.1167/iovs.09-3745.
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    • Jin, Yiping, Sunil K. Chauhan, Daniel R. Saban, and Reza Dana. “Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation.” Invest Ophthalmol Vis Sci 51, no. 2 (February 2010): 816–21. https://doi.org/10.1167/iovs.09-3952.
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    • Jin, Yiping, Makoto Arita, Qiang Zhang, Daniel R. Saban, Sunil K. Chauhan, Nan Chiang, Charles N. Serhan, and Reza Dana. “Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators.” Invest Ophthalmol Vis Sci 50, no. 10 (October 2009): 4743–52. https://doi.org/10.1167/iovs.08-2462.
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    • El Annan, Jaafar, Sunil K. Chauhan, Tatiana Ecoiffier, Qiang Zhang, Daniel R. Saban, and Reza Dana. “Characterization of effector T cells in dry eye disease.” Invest Ophthalmol Vis Sci 50, no. 8 (August 2009): 3802–7. https://doi.org/10.1167/iovs.08-2417.
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    • Zhang, Xian, Linling Shen, Yiping Jin, Daniel R. Saban, Sunil K. Chauhan, and Reza Dana. “Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?” Invest Ophthalmol Vis Sci 50, no. 7 (July 2009): 3137–44. https://doi.org/10.1167/iovs.08-1899.
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    • Chung, Eui-Sang, Daniel R. Saban, Sunil K. Chauhan, and Reza Dana. “Regulation of blood vessel versus lymphatic vessel growth in the cornea.” Invest Ophthalmol Vis Sci 50, no. 4 (April 2009): 1613–18. https://doi.org/10.1167/iovs.08-2212.
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    • Saban, D. R., S. K. Chauhan, X. Zhang, J. El Annan, Y. Jin, and R. Dana. “'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival.” Am J Transplant 9, no. 3 (March 2009): 473–82. https://doi.org/10.1111/j.1600-6143.2008.02535.x.
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    • Chauhan, Sunil K., Jaafar El Annan, Tatiana Ecoiffier, Sunali Goyal, Qiang Zhang, Daniel R. Saban, and Reza Dana. “Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.” J Immunol 182, no. 3 (February 1, 2009): 1247–52. https://doi.org/10.4049/jimmunol.182.3.1247.
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    • Chauhan, Sunil K., Daniel R. Saban, Hyung K. Lee, and Reza Dana. “Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation.” J Immunol 182, no. 1 (January 1, 2009): 148–53. https://doi.org/10.4049/jimmunol.182.1.148.
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    • Saban, Daniel R., Ian A. Elder, Cuong Q. Nguyen, W Clay Smith, Adrian M. Timmers, Maria B. Grant, and Ammon B. Peck. “Characterization of intraocular immunopathology following intracameral inoculation with alloantigen.” Mol Vis 14 (March 26, 2008): 615–24.
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    • Saban, Daniel R., Janet Cornelius, Sharmila Masli, Johannes Schwartzkopff, Maire Doyle, Sunil K. Chauhan, Ammon B. Peck, and Maria B. Grant. “The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens.” Mol Vis 14 (2008): 2435–42.
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    • Doyle, Máire E., Lori Boggs, Robert Attia, Lauren R. Cooper, Daniel R. Saban, Cuong Q. Nguyen, and Ammon B. Peck. “Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition.” Am J Pathol 171, no. 4 (October 2007): 1224–36. https://doi.org/10.2353/ajpath.2007.070388.
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    • Nguyen, Cuong Q., Jue-hua Gao, Hyuna Kim, Daniel R. Saban, Janet G. Cornelius, and Ammon B. Peck. “IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse.” J Immunol 179, no. 1 (July 1, 2007): 382–90. https://doi.org/10.4049/jimmunol.179.1.382.
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    • Sengupta, Nilanjana, Sergio Caballero, Robert N. Mames, Adrian M. Timmers, Daniel Saban, and Maria B. Grant. “Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors.” Invest Ophthalmol Vis Sci 46, no. 1 (January 2005): 343–48. https://doi.org/10.1167/iovs.04-0153.
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  • Book Sections

    • Saban, D. R., and S. MasLi. “Pathobiology of Immune-Mediated Diseases of the Ocular Surface.” In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, 2055–71, 2014. https://doi.org/10.1016/B978-0-12-386456-7.04702-X.
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    • Saban, D. R., M. H. Dastjerdi, and R. Dana. “Corneal graft rejection.” In Ocular Disease: Mechanisms and Management, 56–63, 2010. https://doi.org/10.1016/B978-0-7020-2983-7.00008-5.
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  • Other Articles

    • Blanco, T., and D. R. Saban. “The cornea has "the nerve" to encourage immune rejection.” Am J Transplant, June 2015. https://doi.org/10.1111/ajt.13238.
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  • Conference Papers

    • Saban, Daniel R., Nancy Reyes, Rose Mathew, Chen Yu, Joan Kalnitsky, Victor L. Perez, and Preeya Gupta. “Tear leukocyte phenotyping in meibomian gland dysfunction by large parameter flow cytometry.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.
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    • Steven, Philipp, Sebastian Schwab, Daniel R. Saban, Jerry Y. Niederkorn, and Uta Gehlsen. “Role of Antigen-presenting Cells within Conjunctiva-associated Lymphoid Tissue in the Induction of Ocular Allergy.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.
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    • Jia, Wei, Jonathan C. Poe, Hsuan Su, Glenn K. Matsushima, Jeffrey Rathmell, Kazuhiro Imai, Nancy J. Reyes, et al. “Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd.” In Blood, 128:498–498. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.498.498.
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    • Okoren, Emily, Rose Mathew, and Daniel R. Saban. “Microglia and monocyte-derived macrophage responses to light damage differ across mouse strains.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Reyes, Nancy, and Daniel R. Saban. “Pathogenesis of meibomian gland dysfunction (MGD) requires the T cell-neutrophil axis, in the allergy setting.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Smith, Rachel, Nancy Reyes, and Daniel R. Saban. “Allergic eye disease (AED) progression in the mouse model is associated with quantitative changes in conjunctival innate lymphoid populations.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Zaki, Mohd A., G. Galatowicz, M. Eskandarpour, S. B. Dale-Ahadome, D. R. Saban, and V. L. Calder. “IL-9 upregulation in experimetal allergic conjunctivitis: IL-9R blockade downregulates mast cell responses.” In Allergy, 71:139–139. WILEY-BLACKWELL, 2016.
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    • Blanco, Tomas, and Daniel R. Saban. “Intravital multiphoton visualization identifies inter-networking between nerves and bone marrow derived cells of the mouse cornea.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Dale, Sarah B., Rose Mathew, Nancy Reyes, Tomas Blanco, Virginia L. Calder, and Daniel R. Saban. “A novel contribution for dendritic cells in fibrosis pathobiology as revealed in a mouse model of severe ocular allergy.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Kodati, Shilpa, Yihe Chen, Thomas H. Dohlman, Sunil K. Chauhan, Daniel R. Saban, and Reza Dana. “CCR7 is critical in the induction and maintenance of Th17 immunity in dry eye disease.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Mathew, Rose, Nancy Reyes, Tomas Blanco, and Daniel R. Saban. “Corneal Lymphangiogenesis Contributes to Egress of Corneal Dendritic Cells in a Mouse Model of Ocular Allergy.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • McNabb, Ryan P., Tomas Blanco, Daniel R. Saban, Joseph A. Izatt, and Anthony N. Kuo. “Single Source Fluorescence Imaging/Blue Optical Coherence Tomography in a GFP Mouse Model.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Reyes, Nancy, Tomas Blanco, Rose Mathew, and Daniel R. Saban. “Novel Mouse Model of Severe Ocular Allergy Reveals a Key Role for Pathogenic Th17 Cells.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Smith, Rachel, Nancy Reyes, and Daniel R. Saban. “Dendritic cell derived thrombospondin-1 modulation of primary versus secondary T cell responses in a mouse model of ocular allergy.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Stepp, Mary Ann, Daniel R. Saban, Sonali Pal Ghosh, Ahdeah Pajoohesh-Ganji, Gauri Tadvalkar, Christophe Cataisson, and A Sue Menko. “Resolving wounds induce a more robust cytokine mRNA response and recruitment of larger numbers of neutrophils.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
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    • Grant, Maria B., Ashay D. Bhatwadekar, Ping Hu, Sugata Hazra, Sergio Caballero, Susanne Mohr, Steven F. Abcouwer, et al. “In Type 1 Diabetes Decreased Bone Marrow Neuronal Support Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 Monocytes.” In Circulation, Vol. 126. LIPPINCOTT WILLIAMS & WILKINS, 2012.
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    • Chauhan, S., Y. Jin, S. Goyal, A. Okanobo, H. Lee, D. R. Saban, and R. Dana. “Th17/IL17 Mediates Autoimmunity-Dependent Corneal Lymphangiogenesis in Dry Eye Disease.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Chen, Y., S. K. Chauhan, A. Okanobo, D. R. Saban, and R. Dana. “Regulatory Effects of Early NK Cell Responses on Adaptive Immunity in Dry Eye Disease.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Hos, D., F. Bock, D. R. Saban, B. Regenfuss, J. Onderka, S. Masli, R. Dana, and C. Cursiefen. “Corticosteroids Inhibit Inflammatory Corneal Lymphangigenesis in vivo, but Display Proangiogenic Properties in vitro.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Saban, D. R., S. K. Chauhan, and R. Dana. “Identification and Function of Novel Langerin Positive Dendritic Cells in the Cornea.” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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    • Saban, Daniel R., Sunil K. Chauhan, and Reza Dana. “Phenotypic and Functional Characterization of Corneal Langerhans Cells in Transplantation.” In American Journal of Transplantation, 9:477–477. WILEY-BLACKWELL PUBLISHING, INC, 2009.
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    • Saban, Daniel Raphael, Sunil K. Chauhan, and Reza Dana. “Chimeric Solid Tissue Grafts Diminish Allospecific Immunity.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.
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    • Saban, Daniel R., Maria B. Grant, Cuong Nguyen, Janet G. Cornelius, and Ammon B. Peck. “Immunization of cellular antigens into the anterior chamber impairs cytotoxicity.” In Journal of Immunology, 176:S232–S232. AMER ASSOC IMMUNOLOGISTS, 2006.
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    • Saban, D. R., J. Schwartzkoppf, A. B. Peck, and M. B. Grant. “Preferential production of distinct IgG subclasses in response to anterior chamber immunization with allosplenocytes.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.
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    • Haire, S. E., I. A. Elder, D. R. Saban, J. J. Janssen, and A. M. M. Timmers. “Optimization of lentiviral gene delivery to the retinal pigment epithelium in vivo.” In Investigative Ophthalmology & Visual Science, 44:U89–U89. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.
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    • Samman, T. M. I. el, D. R. Saban, I. A. Elder, T. B. Nguyen, M. B. Grant, and A. M. Timmers. “Prolongation of recombinant adenoviral expression through modulation of the innate ocular immunity.” In Investigative Ophthalmology & Visual Science, 43:U637–U637. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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    • Timmers, A. M., T. B. Nguyen, I. A. Elder, and D. R. Saban. “Lentiviral delivery of DH-sCNTF to RPE in P23H rats rescues photoreceptor cells morphologically but not functionally.” In Investigative Ophthalmology & Visual Science, 43:U636–U636. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.
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    • Timmers, A. M., T. B. Nguyen, D. R. Saban, and M. B. Grant. “Viral vectors for efficient gene delivery to RPE cells.” In Investigative Ophthalmology & Visual Science, 42:S125–S125. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2001.
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