Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Investigator, Immunology, Schepens Eye Research Institute, Harvard Medical School 2009 - 2012
  • Instructor, Ophthalmology, Harvard Medical School 2010 - 2012
  • Research Fellow, Schepens Eye Research Instittute, Harvard Medical School 2006 - 2009
  • Ph.D., University of Florida 2005
  • M.S., University of Florida 2002
• 

  Duke Appointment History

  • Assistant Professor of Ophthalmology, Ophthalmology, Clinical Science Departments 2012 - 2017
  • Instructor in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2012
• Research
• 

  Selected Grants

  • Regulation of inflammation and lipid homeostasis by the aryl hydrocarbon receptor in age-related macular degeneration awarded by National Institutes of Health 2018 - 2022
  • Cellular and Molecular Mechanisms that Contribute to Ocular Surface Disease during Severe Allergic Inflammation awarded by National Institutes of Health 2012 - 2021
  • Immunophenotyping the effect of Xiidra treatment in the inflammatory dry eye disease setting with underlying meibomian gland dysfunction awarded by Shire Pharmaceutical Development US Inc. 2018 - 2020
  • Innate immunity, lipoproteins and AMD progression awarded by National Institutes of Health 2016 - 2019
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by University of Alabama at Birmingham 2017 - 2019
  • Monocytes in Dry Age-Related Macular Degeneration awarded by National Institutes of Health 2016 - 2019
  • Role of bona fide microglia in retinal degeneration awarded by BrightFocus Foundation 2017 - 2019
  • Basic Immunology Training Program awarded by National Institutes of Health 2014 - 2019
  • RPB: 2014 Nelson Trust Award awarded by Research To Prevent Blindness, Inc. 2014 - 2019
  • Evaluation of the effects of topically administered IL-17 antagonist compound on ocular allergy parameters in the severe allergic eye disease (AED) mouse model awarded by Allergan, Inc. 2016 - 2019
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Conjunctival Goblet Cell Mucin Secretion in Inflammation and its Resolution awarded by Schepens Eye Research Institute 2014 - 2018
  • Novel Small Molecule Macrophage Inhibitors for the Treatment of Retinal Diseases awarded by Eyedesis Biosciences LLC 2017 - 2018
  • The role of a macrophage chemotactic factor in AMD awarded by BrightFocus Foundation 2015 - 2017
  • Examining the role of IFN-g+IL-17+ pathogenic Th17 cells in severe ocular allergy awarded by National Institutes of Health 2015 - 2017
  • LXR as a novel therapeutic target in diabetic retinopathy awarded by The Trustees of Indiana University 2015 - 2017
  • Macrophages Drive Neovascular Remodeling in NVAMD awarded by BrightFocus Foundation 2014 - 2016
  • Bone marrow neuropathy drives diabetic retinopathy awarded by The Trustees of Indiana University 2013 - 2016
  • Neuroinflammation: the role of lymphocytes in glaucoma awarded by BrightFocus Foundation 2014 - 2016
  • Molecular Mechanisms of Corneal Recurrent Erosion Formation awarded by The George Washington University 2013 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • O'Koren, EG, Yu, C, Klingeborn, M, Wong, AYW, Prigge, CL, Mathew, R, Kalnitsky, J, Msallam, RA, Silvin, A, Kay, JN, Bowes Rickman, C, Arshavsky, VY, Ginhoux, F, Merad, M, and Saban, DR. "Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration." Immunity (February 26, 2019).  Full Text
    • Reyes, NJ, Mathew, R, and Saban, DR. "Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease." Methods in Molecular Biology (Clifton, N.J.) 1834 (January 2019): 153-164.  Full Text
    • Saban, DR, Hodges, RR, Mathew, R, Reyes, NJ, Yu, C, Kaye, R, Swift, W, Botten, N, Serhan, CN, and Dartt, DA. "Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model." Mucosal Immunology 12, no. 1 (January 2019): 145-153.  Full Text
    • McMenamin, PG, Saban, DR, and Dando, SJ. "Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance." Progress in Retinal and Eye Research (December 12, 2018). (Review)  Full Text
    • Poe, JC, Jia, W, Di Paolo, JA, Reyes, NJ, Kim, JY, Su, H, Sundy, JS, Cardones, AR, Perez, VL, Chen, BJ, Chao, NJ, Cardona, DM, Saban, DR, and Sarantopoulos, S. "SYK inhibitor entospletinib prevents ocular and skin GVHD in mice." Jci Insight 3, no. 19 (October 4, 2018).  Full Text
    • Saban, DR. "New concepts in macrophage ontogeny in the adult neural retina." Cellular Immunology 330 (August 2018): 79-85.  Full Text
    • Reyes, NJ, Yu, C, Mathew, R, Kunnen, CM, Kalnitsky, J, Redfern, RL, Leonardi, A, Perez, VL, MacLeod, AS, Gupta, PK, and Saban, DR. "Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice." Science Translational Medicine 10, no. 451 (July 2018).  Full Text
    • Pastak, M, Kleff, V, Saban, DR, Czugala, M, Steuhl, K-P, Ergün, S, Singer, BB, and Fuchsluger, TA. "Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation." Human Gene Therapy 29, no. 4 (April 2018): 467-479.  Full Text
    • Toomey, CB, Landowski, M, Klingeborn, M, Kelly, U, Deans, J, Dong, H, Harrabi, O, Van Blarcom, T, Yeung, YA, Grishanin, R, Lin, JC, Saban, DR, and Bowes Rickman, C. "Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration." Investigative Ophthalmology & Visual Science 59, no. 2 (February 2018): 662-673.  Full Text
    • Kodati, S, Chauhan, SK, Chen, Y, Emami-Naeini, P, Omoto, M, Dohlman, TH, Stevenson, W, Amouzegar, A, Tummala, G, Saban, DR, and Dana, R. "Interleukin-6 neutralization prolongs corneal allograft survival." Current Trends in Immunology 19 (January 1, 2018): 105-113.
    • Reyes, NJ, Mathew, R, and Saban, DR. "Induction and Characterization of the Allergic Eye Disease Mouse Model." Methods in Molecular Biology (Clifton, N.J.) 1799 (January 2018): 49-57.  Full Text
    • Hammer, SS, Beli, E, Kady, N, Wang, Q, Wood, K, Lydic, TA, Malek, G, Saban, DR, Wang, XX, Hazra, S, Levi, M, Busik, JV, and Grant, MB. "The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor." Ebiomedicine 22 (August 2017): 181-190.  Full Text
    • Reyes, NJ, and Saban, DR. "A Commencement for Eye Commensals." Immunity 47, no. 1 (July 2017): 6-8.  Full Text
    • Beli, E, Dominguez, JM, Hu, P, Thinschmidt, JS, Caballero, S, Calzi, SL, Luo, D, Shanmugam, S, Salazar, TE, Duan, Y, Boulton, ME, Mohr, S, Abcouwer, SF, Saban, DR, Harrison, JK, and Grant, MB. "Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes." Journal of molecular medicine (Berlin, Germany) 95, no. 5 (May 2017): 565-566.  Full Text
    • Reyes, NJ, O'Koren, EG, and Saban, DR. "New insights into mononuclear phagocyte biology from the visual system." Nature Reviews. Immunology 17, no. 5 (May 2017): 322-332. (Review)  Full Text
    • Beli, E, Dominguez, JM, Hu, P, Thinschmidt, JS, Caballero, S, Li Calzi, S, Luo, D, Shanmugam, S, Salazar, TE, Duan, Y, Boulton, ME, Mohr, S, Abcouwer, SF, Saban, DR, Harrison, JK, and Grant, MB. "CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes." Journal of Molecular Medicine (Berlin, Germany) 94, no. 11 (November 2016): 1255-1265.  Full Text
    • McNabb, RP, Blanco, T, Bomze, HM, Tseng, HC, Saban, DR, Izatt, JA, and Kuo, AN. "Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice." Experimental Eye Research 151 (October 2016): 68-74.  Full Text
    • Ahadome, SD, Abraham, DJ, Rayapureddi, S, Saw, VP, Saban, DR, Calder, VL, Norman, JT, Ponticos, M, Daniels, JT, and Dart, JK. "Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring." Jci Insight 1, no. 12 (August 4, 2016): e87001-null.  Full Text
    • Ahadome, SD, Mathew, R, Reyes, NJ, Mettu, PS, Cousins, SW, Calder, VL, and Saban, DR. "Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy." JCI insight 1, no. 12 (August 2016).  Full Text
    • Smith, RE, Reyes, NJ, Khandelwal, P, Schlereth, SL, Lee, HS, Masli, S, and Saban, DR. "Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease." Journal of Leukocyte Biology 100, no. 2 (August 2016): 371-380.  Full Text
    • O'Koren, EG, Mathew, R, and Saban, DR. "Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina." Scientific Reports 6 (February 9, 2016): 20636-null.  Full Text
    • Pajoohesh-Ganji, A, Pal-Ghosh, S, Tadvalkar, G, Kyne, BM, Saban, DR, and Stepp, MA. "Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea." Laboratory investigation; a journal of technical methods and pathology 95, no. 11 (November 2015): 1305-1318.  Full Text
    • Dale, SB, and Saban, DR. "Linking immune responses with fibrosis in allergic eye disease." Current Opinion in Allergy and Clinical Immunology 15, no. 5 (October 2015): 467-475. (Review)  Full Text
    • Saban, D. "Immune Responses at the Ocular Surface." Acta Ophthalmologica 93 (October 2015): n/a-n/a.  Full Text
    • Toomey, CB, Kelly, U, Saban, DR, and Bowes Rickman, C. "Regulation of age-related macular degeneration-like pathology by complement factor H." Proceedings of the National Academy of Sciences of the United States of America 112, no. 23 (June 2015): E3040-E3049.  Full Text
    • Lee, H-S, Hos, D, Blanco, T, Bock, F, Reyes, NJ, Mathew, R, Cursiefen, C, Dana, R, and Saban, DR. "Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease." Investigative Ophthalmology & Visual Science 56, no. 5 (May 2015): 3140-3148.  Full Text
    • Reyes, NJ, and Saban, DR. "T helper subsets in allergic eye disease." Current Opinion in Allergy and Clinical Immunology 14, no. 5 (October 2014): 477-484. (Review)  Full Text
    • Kodati, S, Chauhan, SK, Chen, Y, Dohlman, TH, Karimian, P, Saban, D, and Dana, R. "CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease." Investigative Ophthalmology & Visual Science 55, no. 9 (August 19, 2014): 5871-5877.  Full Text
    • Pal-Ghosh, S, Pajoohesh-Ganji, A, Menko, AS, Oh, H-Y, Tadvalkar, G, Saban, DR, and Stepp, MA. "Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury." Investigative Ophthalmology & Visual Science 55, no. 4 (April 28, 2014): 2757-2765.  Full Text
    • Saban, DR. "The chemokine receptor CCR7 expressed by dendritic cells: a key player in corneal and ocular surface inflammation." The ocular surface 12, no. 2 (April 2014): 87-99. (Review)  Full Text
    • Chauhan, SK, Saban, DR, Dohlman, TH, and Dana, R. "CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue." J Immunol 192, no. 2 (January 15, 2014): 817-823.  Full Text  Link to Item
    • Chen, Y, Chauhan, SK, Lee, HS, Saban, DR, and Dana, R. "Chronic dry eye disease is principally mediated by effector memory Th17 cells." Mucosal Immunology 7, no. 1 (January 2014): 38-45.  Full Text
    • Hu, P, Thinschmidt, JS, Yan, Y, Hazra, S, Bhatwadekar, A, Caballero, S, Salazar, T, Miyan, JA, Li, W, Derbenev, A, Zsombok, A, Tikhonenko, M, Dominguez, JM, McGorray, SP, Saban, DR, Boulton, ME, Busik, JV, Raizada, MK, Chan-Ling, T, and Grant, MB. "CNS inflammation and bone marrow neuropathy in type 1 diabetes." The American Journal of Pathology 183, no. 5 (November 2013): 1608-1620.  Full Text
    • Chen, Y, Chauhan, SK, Lee, HS, Stevenson, W, Schaumburg, CS, Sadrai, Z, Saban, DR, Kodati, S, Stern, ME, and Dana, R. "Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis." Investigative Ophthalmology & Visual Science 54, no. 4 (April 3, 2013): 2457-2464.  Full Text
    • Hazra, S, Jarajapu, YPR, Stepps, V, Caballero, S, Thinschmidt, JS, Sautina, L, Bengtsson, N, Licalzi, S, Dominguez, J, Kern, TS, Segal, MS, Ash, JD, Saban, DR, Bartelmez, SH, and Grant, MB. "Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model." Diabetologia 56, no. 3 (March 2013): 644-653.  Full Text
    • Saban, DR, Calder, V, Kuo, C-H, Reyes, NJ, Dartt, DA, Ono, SJ, and Niederkorn, JY. "New twists to an old story: novel concepts in the pathogenesis of allergic eye disease." Curr Eye Res 38, no. 3 (March 2013): 317-330. (Review)  Full Text  Link to Item
    • Khandelwal, P, Blanco-Mezquita, T, Emami, P, Lee, HS, Reyes, NJ, Mathew, R, Huang, R, and Saban, DR. "Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses." Plos One 8, no. 5 (January 2013): e64193-null.  Full Text
    • Lee, HS, Schlereth, S, Khandelwal, P, and Saban, DR. "Ocular allergy modulation to hi-dose antigen sensitization is a Treg-dependent process." Plos One 8, no. 9 (January 2013): e75769-null.  Full Text
    • Stevenson, W, Cheng, S-F, Emami-Naeini, P, Hua, J, Paschalis, EI, Dana, R, and Saban, DR. "Gamma-irradiation reduces the allogenicity of donor corneas." Investigative Ophthalmology & Visual Science 53, no. 11 (October 2012): 7151-7158.  Full Text
    • Bhatwadekar, AD, Hu, P, Hazra, S, Caballero, S, Mohr, S-S, Abcouwer, SF, Saban, DR, Chan-Ling, T, Busik, JV, and Grant, MB. "Decreased Bone Marrow Neuronal Support in Type 1 Diabetes Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 (CCR2) Monocytes." DIABETES 61 (June 1, 2012): A69-A69.  Link to Item
    • Schlereth, S, Lee, HS, Khandelwal, P, and Saban, DR. "Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis." The American Journal of Pathology 180, no. 6 (June 2012): 2351-2360.  Full Text
    • Hattori, T, Saban, DR, Emami-Naeini, P, Chauhan, SK, Funaki, T, Ueno, H, and Dana, R. "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation." J Leukoc Biol 91, no. 4 (April 2012): 621-627.  Full Text  Link to Item
    • Ueno, H, Ferrari, G, Hattori, T, Saban, DR, Katikireddy, KR, Chauhan, SK, and Dana, R. "Dependence of corneal stem/progenitor cells on ocular surface innervation." Investigative Ophthalmology & Visual Science 53, no. 2 (February 21, 2012): 867-872.  Full Text
    • Dastjerdi, MH, Sadrai, Z, Saban, DR, Zhang, Q, and Dana, R. "Corneal penetration of topical and subconjunctival bevacizumab. (Published online)" Invest Ophthalmol Vis Sci 52, no. 12 (November 7, 2011): 8718-8723.  Full Text  Link to Item
    • Hattori, T, Chauhan, SK, Lee, H, Ueno, H, Dana, R, Kaplan, DH, and Saban, DR. "Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. (Published online)" Invest Ophthalmol Vis Sci 52, no. 7 (June 28, 2011): 4598-4604.  Full Text  Link to Item
    • Chen, Y, Chauhan, SK, Saban, DR, Sadrai, Z, Okanobo, A, and Dana, R. "Interferon-γ-secreting NK cells promote induction of dry eye disease." J Leukoc Biol 89, no. 6 (June 2011): 965-972.  Full Text  Link to Item
    • Sadrai, Z, Hajrasouliha, AR, Chauhan, S, Saban, DR, Dastjerdi, MH, and Dana, R. "Effect of topical azithromycin on corneal innate immune responses. (Published online)" Invest Ophthalmol Vis Sci 52, no. 5 (April 19, 2011): 2525-2531.  Full Text  Link to Item
    • Hos, D, Saban, DR, Bock, F, Regenfuss, B, Onderka, J, Masli, S, and Cursiefen, C. "Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids." Archives of Ophthalmology (Chicago, Ill. : 1960) 129, no. 4 (April 2011): 445-452.  Full Text
    • Cursiefen, C, Maruyama, K, Bock, F, Saban, D, Sadrai, Z, Lawler, J, Dana, R, and Masli, S. "Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes." Journal of Experimental Medicine 208, no. 5 (2011): 1083-1092.  Full Text
    • Vega, JL, Saban, D, Carrier, Y, Masli, S, and Weiner, HL. "Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β." Ocular Immunology and Inflammation 18, no. 6 (December 2010): 459-469.  Full Text
    • Saban, DR, Bock, F, Chauhan, SK, Masli, S, and Dana, R. "Thrombospondin-1 derived from APCs regulates their capacity for allosensitization." J Immunol 185, no. 8 (October 15, 2010): 4691-4697.  Full Text  Link to Item
    • Dastjerdi, MH, Saban, DR, Okanobo, A, Nallasamy, N, Sadrai, Z, Chauhan, SK, Hajrasouliha, AR, and Dana, R. "Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival." Investigative Ophthalmology & Visual Science 51, no. 5 (May 2010): 2411-2417.  Full Text
    • Jin, Y, Chauhan, SK, Saban, DR, and Dana, R. "Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation." Invest Ophthalmol Vis Sci 51, no. 2 (February 2010): 816-821.  Full Text  Link to Item
    • Jin, Y, Arita, M, Zhang, Q, Saban, DR, Chauhan, SK, Chiang, N, Serhan, CN, and Dana, R. "Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators." Investigative Ophthalmology & Visual Science 50, no. 10 (October 2009): 4743-4752.  Full Text
    • El Annan, J, Chauhan, SK, Ecoiffier, T, Zhang, Q, Saban, DR, and Dana, R. "Characterization of effector T cells in dry eye disease." Invest Ophthalmol Vis Sci 50, no. 8 (August 2009): 3802-3807.  Full Text  Link to Item
    • Zhang, X, Shen, L, Jin, Y, Saban, DR, Chauhan, SK, and Dana, R. "Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival?." Invest Ophthalmol Vis Sci 50, no. 7 (July 2009): 3137-3144.  Full Text  Link to Item
    • Chung, E-S, Saban, DR, Chauhan, SK, and Dana, R. "Regulation of blood vessel versus lymphatic vessel growth in the cornea." Invest Ophthalmol Vis Sci 50, no. 4 (April 2009): 1613-1618.  Full Text  Link to Item
    • Saban, DR, Chauhan, SK, Zhang, X, El Annan, J, Jin, Y, and Dana, R. "'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival." Am J Transplant 9, no. 3 (March 2009): 473-482.  Full Text  Link to Item
    • Chauhan, SK, El Annan, J, Ecoiffier, T, Goyal, S, Zhang, Q, Saban, DR, and Dana, R. "Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression." Journal of Immunology (Baltimore, Md. : 1950) 182, no. 3 (February 2009): 1247-1252.  Full Text
    • Chauhan, SK, Saban, DR, Lee, HK, and Dana, R. "Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation." Journal of Immunology (Baltimore, Md. : 1950) 182, no. 1 (January 2009): 148-153.  Full Text
    • Saban, DR, Elder, IA, Nguyen, CQ, Smith, WC, Timmers, AM, Grant, MB, and Peck, AB. "Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. (Published online)" Mol Vis 14 (March 26, 2008): 615-624.  Link to Item
    • Saban, DR, Cornelius, J, Masli, S, Schwartzkopff, J, Doyle, M, Chauhan, SK, Peck, AB, and Grant, MB. "The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens." Mol Vis 14 (2008): 2435-2442.  Link to Item
    • Doyle, ME, Boggs, L, Attia, R, Cooper, LR, Saban, DR, Nguyen, CQ, and Peck, AB. "Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition." The American Journal of Pathology 171, no. 4 (October 2007): 1224-1236.  Full Text
    • Nguyen, CQ, Gao, J-H, Kim, H, Saban, DR, Cornelius, JG, and Peck, AB. "IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse." Journal of Immunology (Baltimore, Md. : 1950) 179, no. 1 (July 2007): 382-390.  Full Text
    • Sengupta, N, Caballero, S, Mames, RN, Timmers, AM, Saban, D, and Grant, MB. "Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors." Investigative Ophthalmology & Visual Science 46, no. 1 (January 2005): 343-348.  Full Text

  • Book Sections

    • Saban, DR, and MasLi, S. "Pathobiology of Immune-Mediated Diseases of the Ocular Surface." In Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, 2055-2071. January 1, 2014.  Full Text
    • Saban, DR, Dastjerdi, MH, and Dana, R. "Corneal graft rejection." In Ocular Disease, 56-63.: Elsevier, 2010.  Full Text

  • Other Articles

    • Blanco, T, and Saban, DR. "The cornea has "the nerve" to encourage immune rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 6 (June 2015): 1453-1454.  Full Text

  • Conference Papers

    • Saban, DR, Reyes, N, Mathew, R, Yu, C, Kalnitsky, J, Perez, VL, and Gupta, P. "Tear leukocyte phenotyping in meibomian gland dysfunction by large parameter flow cytometry." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Honolulu, HI. April 29, 2018 - May 3, 2018.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, July 1, 2018.  Link to Item
    • Steven, P, Schwab, S, Saban, DR, Niederkorn, JY, and Gehlsen, U. "Role of Antigen-presenting Cells within Conjunctiva-associated Lymphoid Tissue in the Induction of Ocular Allergy." Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Honolulu, HI. April 29, 2018 - May 3, 2018.: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, July 1, 2018.  Link to Item
    • Jia, W, Poe, JC, Su, H, Matsushima, GK, Rathmell, J, Imai, K, Reyes, NJ, Cardona, DM, Anand, S, Deoliveira, D, Li, Z, Saban, DR, Chen, BJ, Chao, NJ, and Sarantopoulos, S. "Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd." December 2, 2016.  Link to Item
    • Okoren, E, Mathew, R, and Saban, DR. "Microglia and monocyte-derived macrophage responses to light damage differ across mouse strains." September 2016.  Link to Item
    • Reyes, N, and Saban, DR. "Pathogenesis of meibomian gland dysfunction (MGD) requires the T cell-neutrophil axis, in the allergy setting." September 2016.  Link to Item
    • Smith, R, Reyes, N, and Saban, DR. "Allergic eye disease (AED) progression in the mouse model is associated with quantitative changes in conjunctival innate lymphoid populations." September 2016.  Link to Item
    • Zaki, MA, Galatowicz, G, Eskandarpour, M, Dale-Ahadome, SB, Saban, DR, and Calder, VL. "IL-9 upregulation in experimetal allergic conjunctivitis: IL-9R blockade downregulates mast cell responses." August 2016.  Link to Item
    • Blanco, T, and Saban, DR. "Intravital multiphoton visualization identifies inter-networking between nerves and bone marrow derived cells of the mouse cornea." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Dale, SB, Mathew, R, Reyes, N, Blanco, T, Calder, VL, and Saban, DR. "A novel contribution for dendritic cells in fibrosis pathobiology as revealed in a mouse model of severe ocular allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Kodati, S, Chen, Y, Dohlman, TH, Chauhan, SK, Saban, DR, and Dana, R. "CCR7 is critical in the induction and maintenance of Th17 immunity in dry eye disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Mathew, R, Reyes, N, Blanco, T, and Saban, DR. "Corneal Lymphangiogenesis Contributes to Egress of Corneal Dendritic Cells in a Mouse Model of Ocular Allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • McNabb, RP, Blanco, T, Saban, DR, Izatt, JA, and Kuo, AN. "Single Source Fluorescence Imaging/Blue Optical Coherence Tomography in a GFP Mouse Model." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Reyes, N, Blanco, T, Mathew, R, and Saban, DR. "Novel Mouse Model of Severe Ocular Allergy Reveals a Key Role for Pathogenic Th17 Cells." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Smith, R, Reyes, N, and Saban, DR. "Dendritic cell derived thrombospondin-1 modulation of primary versus secondary T cell responses in a mouse model of ocular allergy." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Stepp, MA, Saban, DR, Ghosh, SP, Pajoohesh-Ganji, A, Tadvalkar, G, Cataisson, C, and Menko, AS. "Resolving wounds induce a more robust cytokine mRNA response and recruitment of larger numbers of neutrophils." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2014.  Link to Item
    • Grant, MB, Bhatwadekar, AD, Hu, P, Hazra, S, Caballero, S, Mohr, S, Abcouwer, SF, Saban, DR, Chan-Ling, T, Busik, JV, and Raizada, MK. "In Type 1 Diabetes Decreased Bone Marrow Neuronal Support Shifts Normal Hematopoiesis Towards the Generation of (C-C Motif) Receptor 2 Monocytes." November 20, 2012.  Link to Item
    • Chauhan, S, Jin, Y, Goyal, S, Okanobo, A, Lee, H, Saban, DR, and Dana, R. "Th17/IL17 Mediates Autoimmunity-Dependent Corneal Lymphangiogenesis in Dry Eye Disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Chen, Y, Chauhan, SK, Okanobo, A, Saban, DR, and Dana, R. "Regulatory Effects of Early NK Cell Responses on Adaptive Immunity in Dry Eye Disease." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Hos, D, Bock, F, Saban, DR, Regenfuss, B, Onderka, J, Masli, S, Dana, R, and Cursiefen, C. "Corticosteroids Inhibit Inflammatory Corneal Lymphangigenesis in vivo, but Display Proangiogenic Properties in vitro." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Identification and Function of Novel Langerin Positive Dendritic Cells in the Cornea." : ASSOC RESEARCH VISION OPHTHALMOLOGY INC, April 1, 2010.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Phenotypic and Functional Characterization of Corneal Langerhans Cells in Transplantation." 2009.  Link to Item
    • Saban, DR, Chauhan, SK, and Dana, R. "Chimeric Solid Tissue Grafts Diminish Allospecific Immunity." April 2008.  Link to Item
    • Saban, DR, Grant, MB, Nguyen, C, Cornelius, JG, and Peck, AB. "Immunization of cellular antigens into the anterior chamber impairs cytotoxicity." April 1, 2006.  Link to Item
    • Saban, DR, Schwartzkoppf, J, Peck, AB, and Grant, MB. "Preferential production of distinct IgG subclasses in response to anterior chamber immunization with allosplenocytes." 2005.  Link to Item
    • Haire, SE, Elder, IA, Saban, DR, Janssen, JJ, and Timmers, AMM. "Optimization of lentiviral gene delivery to the retinal pigment epithelium in vivo." May 2003.  Link to Item
    • Timmers, AM, Nguyen, TB, Elder, IA, and Saban, DR. "Lentiviral delivery of DH-sCNTF to RPE in P23H rats rescues photoreceptor cells morphologically but not functionally." May 2002.  Link to Item
    • el Samman, TMI, Saban, DR, Elder, IA, Nguyen, TB, Grant, MB, and Timmers, AM. "Prolongation of recombinant adenoviral expression through modulation of the innate ocular immunity." May 2002.  Link to Item
    • Timmers, AM, Nguyen, TB, Saban, DR, and Grant, MB. "Viral vectors for efficient gene delivery to RPE cells." March 15, 2001.  Link to Item

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