Danielle Nettere

Journal article NPJ Vaccines · December 19, 2025 Adjuvants play an important role in modulating antigen-specific immune responses. We conducted a comparative adjuvant immunogenicity study in Rhesus macaques using HIV-1 subtype B gp120 envelope protein, B.63521, formulated with aluminum hydroxide gel (AH) ... Full text Link to item Cite

Coinfection with HIV-1 skews iNKT cells toward TCR anergy and limited expansion potential in people with hepatitis C.

Journal article Front Immunol · 2025 INTRODUCTION: Hepatitis C virus (HCV) infection remains a leading cause of morbidity and mortality in people with human immunodeficiency virus (HIV). Liver fibrosis progression is more rapid in people with HIV/HCV coinfection compared to HCV monoinfection ... Full text Link to item Cite

In utero human cytomegalovirus infection expands NK-like FcγRIII+CD8+ T cells that mediate Fc antibody functions.

Journal article J Clin Invest · November 12, 2024 Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the lifespan, yet how this common congenital infection modulates developing fetal immune cell compartments remains underexplored. Using cord blood from neonates with and without con ... Full text Link to item Cite

FcαRI (CD89) is upregulated on subsets of mucosal and circulating NK cells and regulates IgA-class specific signaling and functions.

Journal article Mucosal Immunol · August 2024 Immunoglobulin A (IgA) is the predominant mucosal antibody class with both anti- and pro-inflammatory roles1-3. However, the specific role of the IgA receptor cluster of differentiation (CD)89, expressed by a subset of natural killer (NK) cells, is poorly ... Full text Link to item Cite

Methods for Evaluating Antigen-Specific Cytotoxic T Lymphocyte Frequency and Activity

Book section · January 1, 2024 Antigen-specific Cytotoxic T Lymphocytes (CTLs) can be detected by measuring responsiveness to major histocompatibility complex class I (MHC-I)-presented peptide as the ability to produce cytokines/chemokines or to eliminate target cells. Functional assays ... Full text Cite

HIV vaccines induce CD8⁺ T cells with low antigen receptor sensitivity.

Journal article Science (New York, N.Y.) · December 2023 Current HIV vaccines designed to stimulate CD8+ T cells have failed to induce immunologic control upon infection. The functions of vaccine-induced HIV-specific CD8+ T cells were investigated here in detail. Cytotoxic capacity was sign ... Full text Cite

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques.

Journal article NPJ Vaccines · November 24, 2023 An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy. We hypothesized ... Full text Open Access Link to item Cite