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Darin Clark

Assistant Professor in Radiology
Radiology
DUMC Box 3302, Durham, NC 27710
311 Research Drive, Bryan Research Building Room 156, Durham, NC 27710

Current Appointments & Affiliations


Assistant Professor in Radiology · 2022 - Present Radiology, Clinical Science Departments

Recent Publications


Multivariate investigation of aging in mouse models expressing the Alzheimer's protective APOE2 allele: integrating cognitive metrics, brain imaging, and blood transcriptomics.

Journal Article Brain Struct Funct · January 2024 APOE allelic variation is critical in brain aging and Alzheimer's disease (AD). The APOE2 allele associated with cognitive resilience and neuroprotection against AD remains understudied. We employed a multipronged approach to characterize the transition fr ... Full text Link to item Cite

High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry.

Journal Article PLoS One · 2024 BACKGROUND: Brain region segmentation and morphometry in humanized apolipoprotein E (APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's disease (AD) research by demonstrating how various risk factors affect the brain. Photon-cou ... Full text Open Access Link to item Cite

Multi-Channel Reconstruction (MCR) Toolkit v2.0: open-source Python-based tools for X-ray CT reconstruction

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Recently, we have released the first open-source version of our Multi-Channel CT Reconstruction (MCR) Toolkit (https://gitlab.oit.duke.edu/dpc18/mcr-toolkit-public). The initial release of the Toolkit represents 10 years of development and provides a compl ... Full text Cite
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Recent Grants


Development of a Virtual Preclinical CT Platform for Advanced Imaging and Theranostics in Head and Neck Cancer Research

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029

Detecting Growth of Intracranial Aneurysms Using Non-Invasive Photon Counting CT in a Murine Model.

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2029

Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease

ResearchAssistant Research Professor · Awarded by National Institute on Aging · 2021 - 2026

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Education, Training & Certifications


Duke University · 2015 Ph.D.