Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Plastic Surgery Resident, Surgery, Duke University 2014 - 2017
  • General Surgery Resident, Surgery, University of Washington, School of Medicine 2009 - 2014
  • M.D., University of California - Irvine 2009
  • Ph.D., University of California - Los Angeles 2008
  • B.S., University of Colorado - Boulder 1999
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery, Surgery 2017 - 2020
• Research
• 

  Selected Grants

  • A Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of the RECELL® System Combined with Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction awarded by AVITA Medical Americas, LLC 2020 - 2025
  • Genetic approaches to skin regeneration in zebrafish awarded by National Institutes of Health 2020 - 2025
  • Characterization of Tumor Immunobiological Factors that Promote Lymphovascular Invasion and Dissemination in Locally Advanced Breast Cancer awarded by Department of Defense 2017 - 2022
  • 2021 Duke Flap Course awarded by Checkpoint Surgical 2021
  • A point-of-care, biomarker-based test to predict non-healing in chronic wounds awarded by The Plastic Surgery Foundation 2018 - 2020
  • Antibody-Mediated Inhibition of Tumor Necrosis Factor-Alpha in a Novel Wound Dressing for Hypertrophic Scars awarded by The Plastic Surgery Foundation 2015 - 2017
• 

  External Relationships

  • Checkpoint Surgical
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wickenheisser, Victoria A., Hannah C. Langdell, David A. Brown, and Brett T. Phillips. “Who's Auditioning Who? Applicant-Reported Elements of the Best and Worst Plastic Surgery Subinternships.” Plast Reconstr Surg 149, no. 4 (April 1, 2022): 802e-809e. https://doi.org/10.1097/PRS.0000000000008910.
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    • Price, Meghan J., Rose Tillis, Elizabeth P. Howell, Luis Ramirez, Tara Dalton, César Baëta, Vikram Mehta, et al. “Muscle Flap Closures in Spine Surgery: Predictors of Usage Patterns and Factors Associated With Postoperative Complications From the NSQIP Database.” Clin Spine Surg 35, no. 1 (February 1, 2022): E248–58. https://doi.org/10.1097/BSD.0000000000001217.
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    • Ruppert, David S., Mahmoud M. Mohammed, Mohamed M. Ibrahim, Emilio O. Bachtiar, Kevin Erning, Kayvan Ansari, Jeffrey I. Everitt, et al. “Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold.” Wound Repair Regen 29, no. 6 (November 2021): 1035–50. https://doi.org/10.1111/wrr.12951.
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    • Mariottoni, Paula, Simon W. Jiang, Courtney A. Prestwood, Vaibhav Jain, Jutamas Suwanpradid, Melodi Javid Whitley, Margaret Coates, et al. “Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.” Front Med (Lausanne) 8 (2021): 665873. https://doi.org/10.3389/fmed.2021.665873.
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    • Frank-Ito, Dennis O., David J. Carpenter, Tracy Cheng, Yash J. Avashia, David A. Brown, Adam Glener, Alexander Allori, and Jeffrey R. Marcus. “Computational Analysis of the Mature Unilateral Cleft Lip Nasal Deformity on Nasal Patency.” Plast Reconstr Surg Glob Open 7, no. 5 (May 2019): e2244. https://doi.org/10.1097/GOX.0000000000002244.
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    • Sergesketter, Amanda R., Roger W. Cason, Mohamed M. Ibrahim, Whitney O. Lane, David T. Lubkin, Scott T. Hollenbeck, and David A. Brown. “Perioperative Treatment with a Prolyl Hydroxylase Inhibitor Reduces Necrosis in a Rat Ischemic Skin Flap Model.” Plast Reconstr Surg 143, no. 4 (April 2019): 769e-779e. https://doi.org/10.1097/PRS.0000000000005441.
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    • Marcus, Jeffrey R., David A. Brown, David Carpenter, Adam Glener, Alexander Allori, and Dennis Frank-Ito. “Multimodal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate.” Plast Reconstr Surg 143, no. 3 (March 2019): 865–73. https://doi.org/10.1097/PRS.0000000000005365.
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    • Coates, Margaret, Paula Mariottoni, David L. Corcoran, Hélène Fradin Kirshner, Tarannum Jaleel, David A. Brown, Stephen R. Brooks, John Murray, Maria I. Morasso, and Amanda S. MacLeod. “The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.” Plos One 14, no. 5 (2019): e0216249. https://doi.org/10.1371/journal.pone.0216249.
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    • Dai, Rui, Irene J. Pien, David A. Brown, Andre Marshall, Herbert E. Fuchs, and Jeffrey R. Marcus. “Multiple Recurrent Fibromatosis With Cranial Fasciitis Characteristics in a Pediatric Patient.” J Craniofac Surg 28, no. 7 (October 2017): 1821–23. https://doi.org/10.1097/SCS.0000000000003860.
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    • Friedstat, Jonathan, David A. Brown, and Benjamin Levi. “Chemical, Electrical, and Radiation Injuries.” Clin Plast Surg 44, no. 3 (July 2017): 657–69. https://doi.org/10.1016/j.cps.2017.02.021.
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    • Shammas, Ronnie L., Andrew M. Fales, Bridget M. Crawford, Amy J. Wisdom, Gayathri R. Devi, David A. Brown, Tuan Vo-Dinh, and Scott T. Hollenbeck. “Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation.” Plast Reconstr Surg 139, no. 4 (April 2017): 900e-910e. https://doi.org/10.1097/PRS.0000000000003187.
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    • Crawford, Bridget M., Ronnie L. Shammas, Andrew M. Fales, David A. Brown, Scott T. Hollenbeck, Tuan Vo-Dinh, and Gayathri R. Devi. “Photothermal ablation of inflammatory breast cancer tumor emboli using plasmonic gold nanostars.” Int J Nanomedicine 12 (2017): 6259–72. https://doi.org/10.2147/IJN.S141164.
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    • Brown, David A., Janet Gibbons, Shari Honari, Matthew B. Klein, Tam N. Pham, and Nicole S. Gibran. “Propranolol Dosing Practices in Adult Burn Patients: Implications for Safety and Efficacy.” J Burn Care Res 37, no. 3 (2016): e218–26. https://doi.org/10.1097/BCR.0000000000000240.
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    • Miller, Kyle J., David A. Brown, Mohamed M. Ibrahim, Talisha D. Ramchal, and Howard Levinson. “MicroRNAs in skin tissue engineering.” Adv Drug Deliv Rev 88 (July 1, 2015): 16–36. https://doi.org/10.1016/j.addr.2015.04.018.
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    • Patel, Madhukar S., David A. Brown, and Samuel E. Wilson. “Relevance of the ADAM and UK Small Aneurysm trial data in the age of endovascular aneurysm repair.” Arch Surg 144, no. 9 (September 2009): 806–10. https://doi.org/10.1001/archsurg.2009.148.
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    • Brown, David A., Edward W. Lee, Christopher T. Loh, and Stephen T. Kee. “A new wave in treatment of vascular occlusive disease: biodegradable stents--clinical experience and scientific principles.” J Vasc Interv Radiol 20, no. 3 (March 2009): 315–24. https://doi.org/10.1016/j.jvir.2008.11.007.
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    • Brown, D. A., and A. N. Hasso. “Toward a uniform policy for handling incidental findings in neuroimaging research.” Ajnr Am J Neuroradiol 29, no. 8 (September 2008): 1425–27. https://doi.org/10.3174/ajnr.A1227.
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    • Anderson, Corey D., Sepideh Heydarkhan-Hagvall, Katja Schenke-Layland, Jin Quan Yang, Maria C. Jordan, Jeanne K. Kim, David A. Brown, et al. “The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury.” J Surg Res 148, no. 2 (August 2008): 164–71. https://doi.org/10.1016/j.jss.2007.08.005.
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    • Brown, David A., William R. MacLellan, James C. Y. Dunn, Benjamin M. Wu, and Ramin E. Beygui. “Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue.” Artif Cells Blood Substit Immobil Biotechnol 36, no. 2 (2008): 94–113. https://doi.org/10.1080/10731190801932090.
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    • Brown, David A., William R. Maclellan, Benjamin M. Wu, and Ramin E. Beygui. “Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue.” Ann Biomed Eng 35, no. 11 (November 2007): 1885–97. https://doi.org/10.1007/s10439-007-9360-4.
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    • Brown, David A., W Robb MacLellan, Hillel Laks, James C. Y. Dunn, Benjamin M. Wu, and Ramin E. Beygui. “Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue.” Biotechnol Bioeng 97, no. 4 (July 1, 2007): 962–75. https://doi.org/10.1002/bit.21295.
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    • Brown, David A., Ramin E. Beygui, William R. MacLellan, Hillel Laks, James C. Y. Dunn, and Benjamin M. Wu. “Modulation of gene expression in neonatal rat cardiomyocytes by surface modification of polylactide-co-glycolide substrates.” J Biomed Mater Res A 74, no. 3 (September 1, 2005): 419–29. https://doi.org/10.1002/jbm.a.30344.
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    • Brown, David A., Yu Fen Chou, Ramin E. Beygui, James C. Y. Dunn, and Benjamin M. Wu. “Gelatin-embedded cell-polymer constructs for histological cryosectioning.” J Biomed Mater Res B Appl Biomater 72, no. 1 (January 15, 2005): 79–85. https://doi.org/10.1002/jbm.b.30116.
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  • Book Sections

    • Hollenbeck, Scott, and David A. Brown. “Botulinum toxin.” In Grabb and Smith’s Plastic Surgery. Lippincott Williams & Wilkins, 2019.
    • Brown, D. “Miscellaneous burn injuries.” In ACS Surgery Principles and Practice, 2014.
    • Brown, D., and N. Gibran. “Wound healing.” In Handbook of Burns Volume 1 Acute Burn Care. Springer Science & Business Media, 2012.
    • Brown, D., and N. Gibran. “Tissue engineering applications for burn wounds.” In Advances in Wound Care, Volume 2, 2011.

  • Theses and Dissertations

    • Brown, D. “The effects of mass transport limitations on cell metabolism and viability in a diffusion-limited model of engineered heart tissue,” 2008.
• Teaching & Mentoring
• 

  Recent Courses

  • DECISION 517F: Spreadsheet Modeling and Decision Analysis 2022
  • SURGERY 444C: Introduction to Plastic, Reconstructive and Maxillofacial Surgery 2022
  • SURGERY 223C: From Cosmesis to Reconstruction, from Infants to the Elderly 2021
  • SURGERY 403C: Sub-Internship Plastic Surgery Integrated Program 2021
  • SURGERY 444C: Introduction to Plastic, Reconstructive and Maxillofacial Surgery 2021

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