Current Appointments & Affiliations
House Staff
Medicine,
Clinical Science Departments
House Staff
Medicine, Medical Oncology,
Medicine
Recent Publications
The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.
Journal Article Cell metabolism · December 2022 Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and coincides with type 2 diabetes mellitus (T2DM). However, pharmacological targeting of inflammation lacks durable therapeutic effects in insulin-resistant conditions. ... Full text CiteMitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Journal Article Autophagy · May 2021 Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential autophagy genes in adipocytes paradoxically reduces body weight. Brown adipose tissue (BAT) plays an important role in body weight regulation and metabolic ... Full text CiteEpigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.
Journal Article Oncogene · October 2020 Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures. Here, we show that distinct, stage-wise metabolic alterations in BLCA are associated with the loss of function of aldehyde oxidase (AOX1). AOX1 associate ... Full text CiteRecent Grants
Manipulating Sex Hormone Signaling for Therapeutic Benefit in Liver Cancer
FellowshipPI-Fellow · Awarded by National Institutes of Health · 2025 - 2028Manipulating Sex Hormones to Modulate the Adaptive Antitumor Immune Response for Therapeutic Benefit in Liver Cancer
ResearchPrincipal Investigator · Awarded by American Society of Clinical Oncology · 2025 - 2026View All Grants