David Manfield Brizel
Leonard Prosnitz Distinguished Professor of Radiation Oncology
Head and neck cancer has constituted both my principal clinical and research foci since I came to Duke University in 1987. I designed and led a single institution phase 3 randomized clinical trial, initiated in 1989, which was one of the first in the world to demonstrate that radiotherapy and concurrent chemotherapy (CRT) was more efficacious than radiotherapy alone (RT) for treating locally advanced head and neck cancer. CRT has since been established as the non-surgical standard of care for locally advanced head and neck cancer. Reduction of treatment-induced toxicity has also been a major interest of mine because more intensive therapeutic regimens improve efficacy but also increase morbidity. I was the principal investigator of the pivotal multinational randomized trial of amifostine in head and neck cancer, which established proof of principle for pharmacologic radioprotection and led to FDA approval of this drug for protection against radiation induced xerostomia in the treatment of head and neck cancer in 1999. I have also investigated role of recombinant human keratinocyte growth factor KGF in the amelioration of mucositis in both preclinical and clinical settings.
I have an ongoing commitment to the study of in situ tumor physiology and biology. I was one of the initial investigators to initiate direct measurement of tumor oxygenation in humans on a systematic basis. This work revealed a prognostic relationship between tumor hypoxia and local-regional failure and survival in head and neck. Parallel studies of tumor oxygenation in soft tissue sarcomas resulted in the first published literature to demonstrate that hypoxia at a primary tumor site was associated with a significant increase in the risk of subsequent distant metastatic recurrence after completion of treatment. We have also demonstrated that elevated lactate concentrations in head and neck cancer primary tumors is associated with an increased risk of metastatic failure in patients undergoing primary surgical therapy for head and neck cancer.
These interests and accomplishments provide the foundation for my present efforts, which are devoted to the development of functional metabolic imaging, both MRI and PET. We are using imaging to characterize the inherent, non-treatment induced variability of several physiologic and metabolic parameters in both tumors and normal tissues and to measure treatment induced changes in them. The long- term intent is to improve our abilities to predict treatment outcome, to better understand the relationships between physical dose delivery and the risk of toxicity, and to choose more customized treatment strategies for our patients that will increase the chances of cure and decrease the risks of serious side effects
I have an ongoing commitment to the study of in situ tumor physiology and biology. I was one of the initial investigators to initiate direct measurement of tumor oxygenation in humans on a systematic basis. This work revealed a prognostic relationship between tumor hypoxia and local-regional failure and survival in head and neck. Parallel studies of tumor oxygenation in soft tissue sarcomas resulted in the first published literature to demonstrate that hypoxia at a primary tumor site was associated with a significant increase in the risk of subsequent distant metastatic recurrence after completion of treatment. We have also demonstrated that elevated lactate concentrations in head and neck cancer primary tumors is associated with an increased risk of metastatic failure in patients undergoing primary surgical therapy for head and neck cancer.
These interests and accomplishments provide the foundation for my present efforts, which are devoted to the development of functional metabolic imaging, both MRI and PET. We are using imaging to characterize the inherent, non-treatment induced variability of several physiologic and metabolic parameters in both tumors and normal tissues and to measure treatment induced changes in them. The long- term intent is to improve our abilities to predict treatment outcome, to better understand the relationships between physical dose delivery and the risk of toxicity, and to choose more customized treatment strategies for our patients that will increase the chances of cure and decrease the risks of serious side effects
Current Appointments & Affiliations
- Leonard Prosnitz Distinguished Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2010
- Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2002
- Professor in Head and Neck Surgery and Communication Sciences, Head and Neck Surgery & Communication Sciences, Clinical Science Departments 2010
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1987
Contact Information
- 05135 Morris Bldg, Durham, NC 27710
- Box 3085 Med Ctr, Durham, NC 27710
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david.brizel@duke.edu
(919) 668-5637
- Background
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Education, Training, & Certifications
- M.D., Northwestern University 1983
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Previous Appointments & Affiliations
- Associate Professor in Surgery, Head and Neck Surgery & Communication Sciences, Clinical Science Departments 2008 - 2010
- Associate Professor in Surgery, Surgery, Clinical Science Departments 2006 - 2008
- Associate Professor of Radiation Oncology with Tenure, Radiation Oncology, Clinical Science Departments 1997 - 2001
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1996 - 1997
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1991 - 1995
- Assistant Professor of Radiology, Radiology, Clinical Science Departments 1987 - 1991
- Research
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Selected Grants
- BMX-001 as a Radio-Protector in Head and Neck Cancer Therapy Phase I and Phase II 2017 - 2022
- Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer 2018 - 2022
- NCI National Clinical Trials Network U10 (Year 5) awarded by National Institutes of Health 2014 - 2019
- Digital tomosynthesis: a new paradigm for radiation treatment verification awarded by National Institutes of Health 2007 - 2009
- Measurement of Hypoxia in Non-Small Cell Lung Carcinoma awarded by National Institutes of Health 2002 - 2006
- Hyperglycemia and Oxygen Breathing in Head & Neck Cancer awarded by National Institutes of Health 2000 - 2004
- Predicting Human Tumor Response by 31p MRS awarded by National Institutes of Health 1995 - 2001
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1997 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1995 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1987 - 1999
- Heat & Radiation Effects On Tumor Microcirculation awarded by National Institutes of Health 1997 - 1999
- Effects Of Heat And Radiation On Tumor awarded by National Institutes of Health 1996 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1993 - 1995
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External Relationships
- BioMimetix JVLLC
- KM Pharmaceutical Consulting
- Merck & Co. USA (not assoc'd with Merck KGaA)
- UpToDate, Inc
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Barnes, Justin M., Evan M. Graboyes, Eric Adjei Boakye, Erin E. Kent, Jeffrey F. Scherrer, Eliza M. Park, Donald L. Rosenstein, et al. “The Affordable Care Act and suicide incidence among adults with cancer.” J Cancer Surviv 17, no. 2 (April 2023): 449–59. https://doi.org/10.1007/s11764-022-01205-z.Full Text Link to Item
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Ji, Hangjie, Kyle Lafata, Yvonne Mowery, David Brizel, Andrea L. Bertozzi, Fang-Fang Yin, and Chunhao Wang. “Post-Radiotherapy PET Image Outcome Prediction by Deep Learning Under Biological Model Guidance: A Feasibility Study of Oropharyngeal Cancer Application.” Front Oncol 12 (2022): 895544. https://doi.org/10.3389/fonc.2022.895544.Full Text Link to Item
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Issa, Khalil, Blaine D. Smith, Samantha J. Kaplan, John Madden, David W. Jang, Ali Zomorodi, David Brizel, and Ralph Abi Hachem. “A systematic review on sinonasal mixed adenoneuroendocrine carcinoma.” Int Forum Allergy Rhinol 11, no. 9 (September 2021): 1391–94. https://doi.org/10.1002/alr.22811.Full Text Link to Item
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Straker, Richard J., Yun Song, James Sun, Adrienne B. Shannon, Leah S. Cohen, Elnara Muradova, Hala Daou, et al. “Adjuvant Radiation Therapy for Clinical Stage III Melanoma in the Modern Therapeutic Era.” Ann Surg Oncol 28, no. 7 (July 2021): 3512–21. https://doi.org/10.1245/s10434-020-09384-8.Full Text Link to Item
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Petit, Claire, Benjamin Lacas, Jean-Pierre Pignon, Quynh Thu Le, Vincent Grégoire, Cai Grau, Allan Hackshaw, et al. “Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.” Lancet Oncol 22, no. 5 (May 2021): 727–36. https://doi.org/10.1016/S1470-2045(21)00076-0.Full Text Link to Item
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Lacas, Benjamin, Alexandra Carmel, Cécile Landais, Stuart J. Wong, Lisa Licitra, Jeffrey S. Tobias, Barbara Burtness, et al. “Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.” Radiother Oncol 156 (March 2021): 281–93. https://doi.org/10.1016/j.radonc.2021.01.013.Full Text Link to Item
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Mowery, Yvonne M., Irina Vergalasova, Christel N. Rushing, Kingshuk Roy Choudhury, Donna Niedzwiecki, Qiuwen Wu, David S. Yoo, Shiva Das, Terence Z. Wong, and David M. Brizel. “Early 18F-FDG-PET Response During Radiation Therapy for HPV-Related Oropharyngeal Cancer May Predict Disease Recurrence.” Int J Radiat Oncol Biol Phys 108, no. 4 (November 15, 2020): 969–76. https://doi.org/10.1016/j.ijrobp.2020.08.029.Full Text Open Access Copy Link to Item
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Price, Jeremy G., Daphna Y. Spiegel, David S. Yoo, Michael J. Moravan, Yvonne M. Mowery, Donna Niedzwiecki, David M. Brizel, and Joseph K. Salama. “Development and Implementation of an Educational Simulation Workshop in Fiberoptic Laryngoscopy for Radiation Oncology Residents.” Int J Radiat Oncol Biol Phys 108, no. 3 (November 1, 2020): 615–19. https://doi.org/10.1016/j.ijrobp.2020.05.009.Full Text Link to Item
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Thomson, David J., David Palma, Matthias Guckenberger, Panagiotis Balermpas, Jonathan J. Beitler, Pierre Blanchard, David Brizel, et al. “Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement.” Radiother Oncol 151 (October 2020): 314–21. https://doi.org/10.1016/j.radonc.2020.04.019.Full Text Link to Item
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Thomson, David J., David Palma, Matthias Guckenberger, Panagiotis Balermpas, Jonathan J. Beitler, Pierre Blanchard, David Brizel, et al. “Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement.” Int J Radiat Oncol Biol Phys 107, no. 4 (July 15, 2020): 618–27. https://doi.org/10.1016/j.ijrobp.2020.04.016.Full Text Link to Item
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Pfister, David G., Sharon Spencer, David Adelstein, Douglas Adkins, Yoshimi Anzai, David M. Brizel, Justine Y. Bruce, et al. “Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 7 (July 2020): 873–98. https://doi.org/10.6004/jnccn.2020.0031.Full Text Link to Item
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Wang, Chunhao, Chenyang Liu, Yushi Chang, Kyle Lafata, Yunfeng Cui, Jiahan Zhang, Yang Sheng, Yvonne Mowery, David Brizel, and Fang-Fang Yin. “Dose-Distribution-Driven PET Image-Based Outcome Prediction (DDD-PIOP): A Deep Learning Study for Oropharyngeal Cancer IMRT Application.” Front Oncol 10 (2020): 1592. https://doi.org/10.3389/fonc.2020.01592.Full Text Open Access Copy Link to Item
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Corrigan, Kelsey L., Hannah Williamson, Danielle Elliott Range, Donna Niedzwiecki, David M. Brizel, and Yvonne M. Mowery. “Treatment Outcomes in Anaplastic Thyroid Cancer.” J Thyroid Res 2019 (2019): 8218949. https://doi.org/10.1155/2019/8218949.Full Text Link to Item
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Carpenter, David J., Yvonne M. Mowery, Gloria Broadwater, Anna Rodrigues, Amy J. Wisdom, Jennifer A. Dorth, Pretesh R. Patel, Cynthia K. Shortell, Robert Clough, and David M. Brizel. “The risk of carotid stenosis in head and neck cancer patients after radiation therapy.” Oral Oncol 80 (May 2018): 9–15. https://doi.org/10.1016/j.oraloncology.2018.02.021.Full Text Link to Item
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Colevas, A Dimitrios, Sue S. Yom, David G. Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M. Brizel, et al. “NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018.” J Natl Compr Canc Netw 16, no. 5 (May 2018): 479–90. https://doi.org/10.6004/jnccn.2018.0026.Full Text Link to Item
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Sher, David J., David J. Adelstein, Gopal K. Bajaj, David M. Brizel, Ezra E. Cohen, Aditya Halthore, Louis B. Harrison, et al. “Response to ASTRO consensus guideline for oropharyngeal cancer: In Regard to Walker et al.” Pract Radiat Oncol 8, no. 3 (2018): e185–86. https://doi.org/10.1016/j.prro.2017.08.002.Full Text Link to Item
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Adelstein, David, Maura L. Gillison, David G. Pfister, Sharon Spencer, Douglas Adkins, David M. Brizel, Barbara Burtness, et al. “NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017.” J Natl Compr Canc Netw 15, no. 6 (June 2017): 761–70. https://doi.org/10.6004/jnccn.2017.0101.Full Text Link to Item
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Bauman, Julie E., Ezra Cohen, Robert L. Ferris, David J. Adelstein, David M. Brizel, John A. Ridge, Brian O’Sullivan, et al. “Immunotherapy of head and neck cancer: Emerging clinical trials from a National Cancer Institute Head and Neck Cancer Steering Committee Planning Meeting.” Cancer 123, no. 7 (April 1, 2017): 1259–71. https://doi.org/10.1002/cncr.30449.Full Text Link to Item
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Sher, David J., David J. Adelstein, Gopal K. Bajaj, David M. Brizel, Ezra E. W. Cohen, Aditya Halthore, Louis B. Harrison, et al. “Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline.” Pract Radiat Oncol 7, no. 4 (2017): 246–53. https://doi.org/10.1016/j.prro.2017.02.002.Full Text Link to Item
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Haughey, B. H., P. Sinha, D. Kallogjeri, R. L. Goldberg, J. S. Lewis, J. F. Piccirillo, R. S. Jackson, et al. “Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx.” Oral Oncol 62 (November 2016): 11–19. https://doi.org/10.1016/j.oraloncology.2016.09.004.Full Text Link to Item
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Mowery, Y. M., I. Vergalasova, D. S. Yoo, D. Limon, S. K. Das, W. Y. Hara, and D. M. Brizel. “(18)F-FDG PET/CT Response at 20 Gy Predicts Treatment Outcome for Head and Neck Squamous Cell Carcinoma (HNSCC).” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E378. https://doi.org/10.1016/j.ijrobp.2016.06.1582.Full Text Link to Item
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Hu, Fangyao, Karthik Vishwanath, Joseph K. Salama, Alaattin Erkanli, Bercedis Peterson, James R. Oleson, Walter T. Lee, David M. Brizel, Nimmi Ramanujam, and Mark W. Dewhirst. “Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.” Int J Radiat Oncol Biol Phys 96, no. 2 (October 1, 2016): 462–69. https://doi.org/10.1016/j.ijrobp.2016.06.007.Full Text Link to Item
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Pollom, Erqi L., Jie Song, Benjamin Y. Durkee, Sonya Aggarwal, Timothy Bui, Rie von Eyben, Ruijiang Li, et al. “Prognostic value of midtreatment FDG-PET in oropharyngeal cancer.” Head Neck 38, no. 10 (October 2016): 1472–78. https://doi.org/10.1002/hed.24454.Full Text Link to Item
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Hashemi-Sadraei, Nooshin, Andrew G. Sikora, and David M. Brizel. “Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer.” Am Soc Clin Oncol Educ Book 35 (2016): e277–82. https://doi.org/10.14694/EDBK_157801.Full Text Link to Item
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Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.Full Text Open Access Copy Link to Item
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Schmidt, Matthew, Joseph Y. Lo, Shelby Grzetic, Carly Lutzky, David M. Brizel, and Shiva K. Das. “Semiautomated head-and-neck IMRT planning using dose warping and scaling to robustly adapt plans in a knowledge database containing potentially suboptimal plans.” Med Phys 42, no. 8 (August 2015): 4428–34. https://doi.org/10.1118/1.4923174.Full Text Link to Item
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Pfister, David G., Sharon Spencer, David M. Brizel, Barbara Burtness, Paul M. Busse, Jimmy J. Caudell, Anthony J. Cmelak, et al. “Head and Neck Cancers, Version 1.2015.” J Natl Compr Canc Netw 13, no. 7 (July 2015): 847–55. https://doi.org/10.6004/jnccn.2015.0102.Full Text Link to Item
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Brizel, David M. “Different strokes for different folks: new paradigms for staging oropharynx cancer.” J Clin Oncol 33, no. 8 (March 10, 2015): 817–18. https://doi.org/10.1200/JCO.2014.60.1757.Full Text Link to Item
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Liu, Jeffrey C., John A. Ridge, David M. Brizel, Brian O’Sullivan, Ezra W. Cohen, Bhupinder S. Mann, and David J. Adelstein. “Current status of clinical trials in head and neck cancer 2014.” Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery 152, no. 3 (March 2015): 410–17. https://doi.org/10.1177/0194599814566595.Full Text
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Hoang, Jenny K., Kingshuk Roy Choudhury, Jim Chang, Oana I. Craciunescu, David S. Yoo, and David M. Brizel. “Diffusion-weighted imaging for head and neck squamous cell carcinoma: quantifying repeatability to understand early treatment-induced change.” Ajr Am J Roentgenol 203, no. 5 (November 2014): 1104–8. https://doi.org/10.2214/AJR.14.12838.Full Text Link to Item
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Pfister, David G., Sharon Spencer, David M. Brizel, Barbara Burtness, Paul M. Busse, Jimmy J. Caudell, Anthony J. Cmelak, et al. “Head and neck cancers, Version 2.2014. Clinical practice guidelines in oncology.” J Natl Compr Canc Netw 12, no. 10 (October 2014): 1454–87. https://doi.org/10.6004/jnccn.2014.0142.Full Text Link to Item
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Rao, Nikhil G., Andy Trotti, Jongphil Kim, Michael J. Schell, Xiuhua Zhao, Robert J. Amdur, David M. Brizel, et al. “Phase II multicenter trial of Caphosol for the reduction of mucositis in patients receiving radiation therapy for head and neck cancer.” Oral Oncol 50, no. 8 (August 2014): 765–69. https://doi.org/10.1016/j.oraloncology.2014.06.001.Full Text Link to Item
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Onxley, Jennifer D., David S. Yoo, Naira Muradyan, James R. MacFall, David M. Brizel, and Oana I. Craciunescu. “Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer.” Int J Radiat Oncol Biol Phys 89, no. 3 (July 1, 2014): 658–65. https://doi.org/10.1016/j.ijrobp.2014.03.006.Full Text Link to Item
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Dorth, Jennifer A., Pretesh R. Patel, Gloria Broadwater, and David M. Brizel. “Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy.” Head Neck 36, no. 2 (February 2014): 215–19. https://doi.org/10.1002/hed.23280.Full Text Link to Item
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Pfister, David G., Kie-Kian Ang, David M. Brizel, Barbara A. Burtness, Paul M. Busse, Jimmy J. Caudell, Anthony J. Cmelak, et al. “Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines.” J Natl Compr Canc Netw 11, no. 8 (August 2013): 917–23. https://doi.org/10.6004/jnccn.2013.0113.Full Text Link to Item
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Hoang, J. K., S. K. Das, K. R. Choudhury, D. S. Yoo, and D. M. Brizel. “Using FDG-PET to measure early treatment response in head and neck squamous cell carcinoma: quantifying intrinsic variability in order to understand treatment-induced change.” Ajnr Am J Neuroradiol 34, no. 7 (July 2013): 1428–33. https://doi.org/10.3174/ajnr.A3412.Full Text Link to Item
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Cabrera, Alvin R., David S. Yoo, and David M. Brizel. “Contemporary radiotherapy in head and neck cancer: balancing chance for cure with risk for complication.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 579–98. https://doi.org/10.1016/j.soc.2013.02.001.Full Text Link to Item
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Zhong, Jim, Narasimhan Rajaram, David M. Brizel, Amy E. Frees, Nirmala Ramanujam, Ines Batinic-Haberle, and Mark W. Dewhirst. “Radiation induces aerobic glycolysis through reactive oxygen species.” Radiother Oncol 106, no. 3 (March 2013): 390–96. https://doi.org/10.1016/j.radonc.2013.02.013.Full Text Link to Item
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Adelstein, David J., John A. Ridge, David M. Brizel, F Christopher Holsinger, Bruce H. Haughey, Brian O’Sullivan, Eric M. Genden, et al. “Transoral resection of pharyngeal cancer: summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6-7, 2011, Arlington, Virginia.” Head Neck 34, no. 12 (December 2012): 1681–1703. https://doi.org/10.1002/hed.23136.Full Text Link to Item
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Quon, Harry, and David M. Brizel. “Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas.” Semin Radiat Oncol 22, no. 3 (July 2012): 220–32. https://doi.org/10.1016/j.semradonc.2012.03.007.Full Text Link to Item
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Cuneo, K. C., T. M. Zagar, D. M. Brizel, D. S. Yoo, J. K. Hoang, Z. Chang, Z. Wang, et al. “Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves.” Technol Cancer Res Treat 11, no. 3 (June 2012): 221–28. https://doi.org/10.7785/tcrt.2012.500290.Full Text Link to Item
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Lee, Walter T., David S. Yoo, Liana Puscas, David Witsell, Seth M. Cohen, Samuel R. Fisher, Richard Scher, et al. “Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.” Head Neck 34, no. 6 (June 2012): 792–96. https://doi.org/10.1002/hed.21813.Full Text Link to Item
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Onxley, J., D. Yoo, N. Muradyan, J. MacFall, D. Brizel, and O. Craciunescu. “SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.” Med Phys 39, no. 6Part3 (June 2012): 3615–16. https://doi.org/10.1118/1.4734678.Full Text Link to Item
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Ren, Lei, Indrin J. Chetty, Junan Zhang, Jian-Yue Jin, Q Jackie Wu, Hui Yan, David M. Brizel, W Robert Lee, Benjamin Movsas, and Fang-Fang Yin. “Development and clinical evaluation of a three-dimensional cone-beam computed tomography estimation method using a deformation field map.” Int J Radiat Oncol Biol Phys 82, no. 5 (April 1, 2012): 1584–93. https://doi.org/10.1016/j.ijrobp.2011.02.002.Full Text Link to Item
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Pfister, David G., Kie-Kian Ang, David M. Brizel, Barbara Burtness, Anthony J. Cmelak, A Dimitrios Colevas, Frank Dunphy, et al. “Mucosal melanoma of the head and neck.” J Natl Compr Canc Netw 10, no. 3 (March 2012): 320–38. https://doi.org/10.6004/jnccn.2012.0033.Full Text Link to Item
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Craciunescu, Oana I., David S. Yoo, Esi Cleland, Naira Muradyan, Madeline D. Carroll, James R. MacFall, Daniel P. Barboriak, and David M. Brizel. “Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.” Int J Radiat Oncol Biol Phys 82, no. 3 (March 1, 2012): e345–50. https://doi.org/10.1016/j.ijrobp.2011.05.059.Full Text Link to Item
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Yoo, David S., John P. Kirkpatrick, Oana Craciunescu, Gloria Broadwater, Bercedis L. Peterson, Madeline D. Carroll, Robert Clough, et al. “Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.” Clin Cancer Res 18, no. 5 (March 1, 2012): 1404–14. https://doi.org/10.1158/1078-0432.CCR-11-1982.Full Text Link to Item
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Higgins, Kristin A., Jenny K. Hoang, Michael C. Roach, Junzo Chino, David S. Yoo, Timothy G. Turkington, and David M. Brizel. “Analysis of pretreatment FDG-PET SUV parameters in head-and-neck cancer: tumor SUVmean has superior prognostic value.” Int J Radiat Oncol Biol Phys 82, no. 2 (February 1, 2012): 548–53. https://doi.org/10.1016/j.ijrobp.2010.11.050.Full Text Link to Item
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Roach, Michael C., Timothy G. Turkington, Kristin A. Higgins, Thomas C. Hawk, Jenny K. Hoang, and David M. Brizel. “FDG-PET assessment of the effect of head and neck radiotherapy on parotid gland glucose metabolism.” Int J Radiat Oncol Biol Phys 82, no. 1 (January 1, 2012): 321–26. https://doi.org/10.1016/j.ijrobp.2010.08.055.Full Text Link to Item
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Das, S. K., D. S. Yoo, O. Craciunescu, J. Hoang, and D. M. Brizel. “The Use of Serial FDG-PET Scanning to Develop Metabolic Response Criteria to Chemoradiation in Head and Neck Cancer (HNC).” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S531–S531. https://doi.org/10.1016/j.ijrobp.2011.06.823.Full Text
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Bourhis, Jean, Pierre Blanchard, Emilie Maillard, David M. Brizel, Benjamin Movsas, Jens Buentzel, Johannes A. Langendijk, et al. “Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.” J Clin Oncol 29, no. 18 (June 20, 2011): 2590–97. https://doi.org/10.1200/JCO.2010.33.1454.Full Text Link to Item
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Brizel, David M., William Lydiatt, and A Dimitrios Colevas. “Controversies in the locoregional management of head and neck cancer.” J Natl Compr Canc Netw 9, no. 6 (June 1, 2011): 653–62. https://doi.org/10.6004/jnccn.2011.0054.Full Text Link to Item
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Pfister, David G., Kie-Kian Ang, David M. Brizel, Barbara A. Burtness, Anthony J. Cmelak, A Dimitrios Colevas, Frank Dunphy, et al. “Head and neck cancers.” J Natl Compr Canc Netw 9, no. 6 (June 1, 2011): 596–650. https://doi.org/10.6004/jnccn.2011.0053.Full Text Link to Item
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Brizel, David M. “Head and neck cancer as a model for advances in imaging prognosis, early assessment, and posttherapy evaluation.” Cancer J 17, no. 3 (2011): 159–65. https://doi.org/10.1097/PPO.0b013e31821e8a09.Full Text Link to Item
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Yoo, David S., Terence Z. Wong, and David M. Brizel. “The role of adaptive and functional imaging modalities in radiation therapy: approach and application from a radiation oncology perspective.” Semin Ultrasound Ct Mr 31, no. 6 (December 2010): 444–61. https://doi.org/10.1053/j.sult.2010.10.002.Full Text Link to Item
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Craciunescu, Oana, David Brizel, Esi Cleland, David Yoo, Naira Muradyan, Madeline Carroll, Daniel Barboriak, and James MacFall. “Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).” Med Phys 37, no. 6Part1 (June 2010): 2683–92. https://doi.org/10.1118/1.3427487.Full Text Link to Item
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Salama, Joseph K., Robert I. Haddad, Merril S. Kies, Paul M. Busse, Lei Dong, David M. Brizel, Avraham Eisbruch, Roy B. Tishler, Andy M. Trotti, and Adam S. Garden. “Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer.” Int J Radiat Oncol Biol Phys 75, no. 3 (November 1, 2009): 725–33. https://doi.org/10.1016/j.ijrobp.2008.11.059.Full Text Link to Item
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Murphy, Barbara A., Jennifer L. Beaumont, John Isitt, Adam S. Garden, Clement K. Gwede, Andy M. Trotti, Ruby F. Meredith, et al. “Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy.” J Pain Symptom Manage 38, no. 4 (October 2009): 522–32. https://doi.org/10.1016/j.jpainsymman.2008.12.004.Full Text Link to Item
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Chino, Junzo P., John H. Sampson, Debara L. Tucci, David M. Brizel, and John P. Kirkpatrick. “Paraganglioma of the head and neck: long-term local control with radiotherapy.” Am J Clin Oncol 32, no. 3 (June 2009): 304–7. https://doi.org/10.1097/COC.0b013e318187dd94.Full Text Link to Item
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Brizel, David M. “Targeting the future in head and neck cancer.” Lancet Oncol 10, no. 3 (March 2009): 204–5. https://doi.org/10.1016/S1470-2045(09)70051-8.Full Text Link to Item
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Brizel, David M. “Head and neck cancer. Introduction.” Semin Radiat Oncol 19, no. 1 (January 2009): 1–2. https://doi.org/10.1016/j.semradonc.2008.09.001.Full Text Link to Item
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Brizel, David M., and Everett E. Vokes. “Induction chemotherapy: to use or not to use? That is the question.” Semin Radiat Oncol 19, no. 1 (January 2009): 11–16. https://doi.org/10.1016/j.semradonc.2008.09.003.Full Text Link to Item
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National Comprehensive Cancer Network, Frank, Arlene A. Forastiere, Kie-Kian Ang, David Brizel, Bruce E. Brockstein, Barbara A. Burtness, Anthony J. Cmelak, et al. “Head and neck cancers.” J Natl Compr Canc Netw 6, no. 7 (August 2008): 646–95. https://doi.org/10.6004/jnccn.2008.0051.Full Text Link to Item
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Brizel, David M., Barbara A. Murphy, David I. Rosenthal, Kishan J. Pandya, Stefan Glück, Herbert E. Brizel, Ruby F. Meredith, Dietmar Berger, Mon-Gy Chen, and William Mendenhall. “Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma.” J Clin Oncol 26, no. 15 (May 20, 2008): 2489–96. https://doi.org/10.1200/JCO.2007.13.7349.Full Text Link to Item
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Koontz, Bridget F., Edward F. Miles, Mary Ann D. Rubio, John F. Madden, Samuel R. Fisher, Richard L. Scher, and David M. Brizel. “Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.” Head Neck 30, no. 2 (February 2008): 262–66. https://doi.org/10.1002/hed.20674.Full Text Link to Item
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Bensinger, William, Mark Schubert, Kie-Kian Ang, David Brizel, Elizabeth Brown, June G. Eilers, Linda Elting, et al. “NCCN Task Force Report. prevention and management of mucositis in cancer care.” J Natl Compr Canc Netw 6 Suppl 1 (January 2008): S1-21.Link to Item
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Vujaskovic, Zeljko, Bradley A. Thrasher, Isabel L. Jackson, Marla B. Brizel, and David M. Brizel. “Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents.” Int J Radiat Oncol Biol Phys 69, no. 2 (October 1, 2007): 534–40. https://doi.org/10.1016/j.ijrobp.2007.05.062.Full Text Link to Item
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Wu, Q Jackie, Devon J. Godfrey, Zhiheng Wang, Junan Zhang, Sumin Zhou, Sua Yoo, David M. Brizel, and Fang-Fang Yin. “On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.” Int J Radiat Oncol Biol Phys 69, no. 2 (October 1, 2007): 598–606. https://doi.org/10.1016/j.ijrobp.2007.05.045.Full Text Link to Item
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Brizel, David M. “Pharmacologic approaches to radiation protection.” J Clin Oncol 25, no. 26 (September 10, 2007): 4084–89. https://doi.org/10.1200/JCO.2007.11.5816.Full Text Link to Item
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Vokes, E. E., D. M. Brizel, and T. S. Lawrence. “Concomitant chemoradiotherapy.” Journal of Clinical Oncology 25, no. 26 (September 10, 2007): 4031–32. https://doi.org/10.1200/JCO.2007.13.8073.Full Text
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Kasibhatla, Mohit, John P. Kirkpatrick, and David M. Brizel. “How much radiation is the chemotherapy worth in advanced head and neck cancer?” Int J Radiat Oncol Biol Phys 68, no. 5 (August 1, 2007): 1491–95. https://doi.org/10.1016/j.ijrobp.2007.03.025.Full Text Link to Item
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Moon, Eui Jung, David M. Brizel, Jen-Tsan Ashley Chi, and Mark W. Dewhirst. “The potential role of intrinsic hypoxia markers as prognostic variables in cancer.” Antioxid Redox Signal 9, no. 8 (August 2007): 1237–94. https://doi.org/10.1089/ars.2007.1623.Full Text Link to Item
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Epstein, Joel B., Jennifer L. Beaumont, Clement K. Gwede, Barbara Murphy, Adam S. Garden, Ruby Meredith, Quynh-Thu Le, David Brizel, John Isitt, and David Cella. “Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire.” Cancer 109, no. 9 (May 1, 2007): 1914–22. https://doi.org/10.1002/cncr.22620.Full Text Link to Item
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Isitt, J., B. A. Murphy, J. L. Beaumont, A. S. Garden, C. K. Gwede, A. Trotti, R. F. Meredith, et al. “Oral mucositis-related morbidity and resource utilization in a prospective study of head and neck cancer patients.” Journal of Supportive Oncology 5, no. 4 SUPPL. 2 (April 1, 2007): 54–55.
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Anné, Pramila Rani, Mitchell Machtay, David I. Rosenthal, David M. Brizel, William H. Morrison, David H. Irwin, Prakash B. Chougule, Noel C. Estopinal, Anthony Berson, and Walter J. Curran. “A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer.” Int J Radiat Oncol Biol Phys 67, no. 2 (February 1, 2007): 445–52. https://doi.org/10.1016/j.ijrobp.2006.08.044.Full Text Link to Item
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Dewhirst, Mark W., Isabel Cardenas Navia, David M. Brizel, Christopher Willett, and Timothy W. Secomb. “Multiple etiologies of tumor hypoxia require multifaceted solutions.” Clin Cancer Res 13, no. 2 Pt 1 (January 15, 2007): 375–77. https://doi.org/10.1158/1078-0432.CCR-06-2629.Full Text Link to Item
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Isitt, J., B. A. Murphy, J. L. Beaumont, A. S. Garden, C. K. Gwede, A. Trotti, R. F. Meredith, et al. “Oral mucositis (OM) related morbidity and resource utilization in a prospective study of head and neck cancer (HNC) patients.” J Clin Oncol 24, no. 18_suppl (June 20, 2006): 5539.Link to Item
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Brizel, David M., and Ramon Esclamado. “Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum.” J Clin Oncol 24, no. 17 (June 10, 2006): 2612–17. https://doi.org/10.1200/JCO.2005.05.2829.Full Text Link to Item
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Lanzen, Jennifer, Rod D. Braun, Bruce Klitzman, David Brizel, Timothy W. Secomb, and Mark W. Dewhirst. “Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.” Cancer Res 66, no. 4 (February 15, 2006): 2219–23. https://doi.org/10.1158/0008-5472.CAN-03-2958.Full Text Link to Item
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Kirkpatrick, John P., Matthew E. Hardee, Stacey A. Snyder, Catherine M. Peltz, Yulin Zhao, David M. Brizel, Mark W. Dewhirst, and Kimberly L. Blackwell. “The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.” Radiat Res 165, no. 2 (February 2006): 192–201. https://doi.org/10.1667/rr3499.1.Full Text Link to Item
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Wasserman, Todd H., David M. Brizel, Michael Henke, Alain Monnier, Francois Eschwege, Rolf Sauer, and Vratislav Strnad. “Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trial.” Int J Radiat Oncol Biol Phys 63, no. 4 (November 15, 2005): 985–90. https://doi.org/10.1016/j.ijrobp.2005.07.966.Full Text Link to Item
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Nordsmark, Marianne, Søren M. Bentzen, Volker Rudat, David Brizel, Eric Lartigau, Peter Stadler, Axel Becker, et al. “Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.” Radiother Oncol 77, no. 1 (October 2005): 18–24. https://doi.org/10.1016/j.radonc.2005.06.038.Full Text Link to Item
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Anscher, Mitchell S., Liguang Chen, Zahid Rabbani, Song Kang, Nicole Larrier, Hong Huang, Thaddeus V. Samulski, et al. “Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.” Int J Radiat Oncol Biol Phys 62, no. 1 (May 1, 2005): 255–59. https://doi.org/10.1016/j.ijrobp.2005.01.040.Full Text Link to Item
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Forastiere, Arlene A., Kian Ang, David Brizel, Bruce Earl Brockstein, Frank Dunphy, David W. Eisele, Helmuth Goepfert, et al. “Head and neck cancers.” J Natl Compr Canc Netw 3, no. 3 (May 2005): 316–91. https://doi.org/10.6004/jnccn.2005.0019.Full Text Link to Item
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Prosnitz, Robert G., Bin Yao, Catherine L. Farrell, Robert Clough, and David M. Brizel. “Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer.” Int J Radiat Oncol Biol Phys 61, no. 4 (March 15, 2005): 1087–95. https://doi.org/10.1016/j.ijrobp.2004.07.710.Full Text Link to Item
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Dewhirst, Mark W., Jean M. Poulson, Daohai Yu, Linda Sanders, Michaël Lora-Michiels, Zeljko Vujaskovic, Ellen L. Jones, et al. “Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy.” Int J Radiat Oncol Biol Phys 61, no. 2 (February 1, 2005): 480–91. https://doi.org/10.1016/j.ijrobp.2004.06.211.Full Text Link to Item
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Chen, Liguang, David M. Brizel, Zahid N. Rabbani, Thaddeus V. Samulski, Catherine L. Farrell, Nicole Larrier, Mitchell S. Anscher, and Zeljko Vujaskovic. “The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats.” Int J Radiat Oncol Biol Phys 60, no. 5 (December 1, 2004): 1520–29. https://doi.org/10.1016/j.ijrobp.2004.07.729.Full Text Link to Item
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Robbins, K Thomas, Alfio Ferlito, Carlos Suárez, David M. Brizel, Patrick J. Bradley, Phillip K. Pellitteri, Gary L. Clayman, Luiz P. Kowalski, Eric M. Genden, and Alessandra Rinaldo. “Is there a role for selective neck dissection after chemoradiation for head and neck cancer?” J Am Coll Surg 199, no. 6 (December 2004): 913–16. https://doi.org/10.1016/j.jamcollsurg.2004.08.022.Full Text Link to Item
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Boccia, Ralph, Pramila Rani Anné, Jean Bourhis, David Brizel, Carrie Daly, Nathaniel Holloway, Sharon Hymes, et al. “Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP).” Int J Radiat Oncol Biol Phys 60, no. 1 (September 1, 2004): 302–9. https://doi.org/10.1016/j.ijrobp.2004.02.026.Full Text Link to Item
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Cárdenas-Navia, L Isabel, Daohai Yu, Rod D. Braun, David M. Brizel, Timothy W. Secomb, and Mark W. Dewhirst. “Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.” Cancer Res 64, no. 17 (September 1, 2004): 6010–17. https://doi.org/10.1158/0008-5472.CAN-03-0947.Full Text Link to Item
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Jones, E. L., L. R. Prosnitz, M. W. Dewhirst, P. K. Marcom, P. H. Hardenbergh, L. B. Marks, D. M. Brizel, Z. Vujaskovic, and T. A. Buchholz. “Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.” Women’S Oncology Review 4, no. 3 (September 1, 2004): 221–22. https://doi.org/10.1080/14733400400012958.Full Text
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Brizel, D. M., and T. Wasserman. “The influence of intravenous amifostine on xerostomia and survival during radiotherapy for head and neck cancer: Two year follow-up of a prospective randomized trial.” J Clin Oncol 22, no. 14_suppl (July 15, 2004): 5536.Link to Item
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Jones, Ellen L., Leonard R. Prosnitz, Mark W. Dewhirst, P Kelly Marcom, Patricia H. Hardenbergh, Lawrence B. Marks, David M. Brizel, and Zeljko Vujaskovic. “Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.” Clin Cancer Res 10, no. 13 (July 1, 2004): 4287–93. https://doi.org/10.1158/1078-0432.CCR-04-0133.Full Text Link to Item
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Brizel, David M., Robert G. Prosnitz, Shannon Hunter, Samuel R. Fisher, Robert L. Clough, Mary Ann Downey, and Richard L. Scher. “Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer.” Int J Radiat Oncol Biol Phys 58, no. 5 (April 1, 2004): 1418–23. https://doi.org/10.1016/j.ijrobp.2003.09.004.Full Text Link to Item
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Blackwell, Kimberly L., John P. Kirkpatrick, Stacey A. Snyder, Gloria Broadwater, Francis Farrell, Linda Jolliffe, David M. Brizel, and Mark W. Dewhirst. “Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin.” Cancer Res 63, no. 19 (October 1, 2003): 6162–65.Link to Item
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Erickson, Kristian, Rod D. Braun, Daohai Yu, Jennifer Lanzen, David Wilson, David M. Brizel, Timothy W. Secomb, John E. Biaglow, and Mark W. Dewhirst. “Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation.” Cancer Res 63, no. 15 (August 1, 2003): 4705–12.Link to Item
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Eisbruch, Avraham, Nelson Rhodus, David Rosenthal, Barbara Murphy, Coen Rasch, Stephen Sonis, Charles Scarantino, and David Brizel. “The prevention and treatment of radiotherapy - induced xerostomia.” Semin Radiat Oncol 13, no. 3 (July 2003): 302–8. https://doi.org/10.1016/S1053-4296(03)00027-4.Full Text Link to Item
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Eisbruch, Avraham, Nelson Rhodus, David Rosenthal, Barbara Murphy, Coen Rasch, Stephen Sonis, Charles Scarantino, and David Brizel. “How should we measure and report radiotherapy-induced xerostomia?” Semin Radiat Oncol 13, no. 3 (July 2003): 226–34. https://doi.org/10.1016/S1053-4296(03)00033-X.Full Text Link to Item
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Brizel, David M., and Jens Overgaard. “Does amifostine have a role in chemoradiation treatment?” Lancet Oncol 4, no. 6 (June 2003): 378–81. https://doi.org/10.1016/s1470-2045(03)01132-x.Full Text Link to Item
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Kirkpatrick, John P., David M. Brizel, and Mark W. Dewhirst. “A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.” Radiat Res 159, no. 3 (March 2003): 336–44. https://doi.org/10.1667/0033-7587(2003)159[0336:ammoto]2.0.co;2.Full Text Link to Item
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Jamieson, T. A., D. M. Brizel, J. K. Killian, Y. Oka, H. S. Jang, X. Fu, R. W. Clough, R. T. Vollmer, M. S. Anscher, and R. L. Jirtle. “M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.” Bmc Cancer 3 (February 13, 2003). https://doi.org/10.1186/1471-2407-3-4.Full Text
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Jamieson, Timothy A., David M. Brizel, J Keith Killian, Yoshihiko Oka, Hong-Seok Jang, Xiaolong Fu, Robert W. Clough, Robin T. Vollmer, Mitchell S. Anscher, and Randy L. Jirtle. “M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis.” Bmc Cancer 3 (February 13, 2003): 4. https://doi.org/10.1186/1471-2407-3-4.Full Text Link to Item
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Vujaskovic, Z., E. L. Rosen, K. L. Blackwell, E. L. Jones, D. M. Brizel, L. R. Prosnitz, T. V. Samulski, and M. W. Dewhirst. “Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment.” Int J Hyperthermia 19, no. 5 (2003): 498–506. https://doi.org/10.1080/0265673031000121517.Full Text Link to Item
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Vujaskovic, Zeljko, Qin-Fu Feng, Zahid N. Rabbani, Mitchell S. Anscher, Thaddeus V. Samulski, and David M. Brizel. “Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity.” Radiat Res 157, no. 6 (June 2002): 656–60. https://doi.org/10.1667/0033-7587(2002)157[0656:rolbai]2.0.co;2.Full Text Link to Item
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Vujaskovic, Zeljko, Qin Fu Feng, Zahid N. Rabbani, Thaddeus V. Samulski, Mitchell S. Anscher, and David M. Brizel. “Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity.” Exp Lung Res 28, no. 7 (2002): 577–90. https://doi.org/10.1080/01902140290096791.Full Text Link to Item
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Weber, R. S., E. Abemayor, G. L. Adams, D. J. Adelstein, A. Alavi, E. Alford, M. Al-Sarraf, et al. “Head and neck: Editorial.” Head and Neck 23, no. 12 (December 13, 2001): 1021–23. https://doi.org/10.1002/hed.1148.Full Text
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Walenta, S., S. Snyder, Z. A. Haroon, R. D. Braun, K. Amin, D. Brizel, W. Mueller-Klieser, B. Chance, and M. W. Dewhirst. “Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.” Int J Radiat Oncol Biol Phys 51, no. 3 (November 1, 2001): 840–48. https://doi.org/10.1016/s0360-3016(01)01700-x.Full Text Link to Item
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Snyder, S. A., J. L. Lanzen, R. D. Braun, G. Rosner, T. W. Secomb, J. Biaglow, D. M. Brizel, and M. W. Dewhirst. “Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone.” Int J Radiat Oncol Biol Phys 51, no. 2 (October 1, 2001): 494–506. https://doi.org/10.1016/s0360-3016(01)01654-6.Full Text Link to Item
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Wasserman, T. H., and D. M. Brizel. “The role of amifostine as a radioprotector.” Oncology (Williston Park) 15, no. 10 (October 2001): 1349–54.Link to Item
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Brizel, D. M., T. Schroeder, R. L. Scher, S. Walenta, R. W. Clough, M. W. Dewhirst, and W. Mueller-Klieser. “Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.” Int J Radiat Oncol Biol Phys 51, no. 2 (October 1, 2001): 349–53. https://doi.org/10.1016/s0360-3016(01)01630-3.Full Text Link to Item
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Wasserman, T. H., and D. M. Brizel. “Has the outlook improved for amifostine as a clinical radioprotector.” Radiother Oncol 60, no. 3 (September 2001): 334–36. https://doi.org/10.1016/s0167-8140(01)00402-9.Full Text Link to Item
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Vikram, B. “Phase III randomized trial of amifostine as a radioprotector in head and neck cancer.” J Clin Oncol 19, no. 4 (February 15, 2001): 1233–34. https://doi.org/10.1200/JCO.2001.19.4.1233.Full Text Link to Item
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Maguire, P. D., T. V. Samulski, L. R. Prosnitz, E. L. Jones, G. L. Rosner, B. Powers, L. W. Layfield, et al. “A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy.” Int J Hyperthermia 17, no. 4 (2001): 283–90. https://doi.org/10.1080/02656730110039449.Full Text Link to Item
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Wasserman, T., J. I. Mackowiak, D. M. Brizel, W. Oster, J. Zhang, P. J. Peeples, and R. Sauer. “Effect of amifostine on patient assessed clinical benefit in irradiated head and neck cancer.” Int J Radiat Oncol Biol Phys 48, no. 4 (November 1, 2000): 1035–39. https://doi.org/10.1016/s0360-3016(00)00735-5.Full Text Link to Item
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Dewhirst, M. W., B. Klitzman, R. D. Braun, D. M. Brizel, Z. A. Haroon, and T. W. Secomb. “Review of methods used to study oxygen transport at the microcirculatory level.” Int J Cancer 90, no. 5 (October 20, 2000): 237–55.Link to Item
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Brizel, D. M., T. H. Wasserman, M. Henke, V. Strnad, V. Rudat, A. Monnier, F. Eschwege, et al. “Phase III randomized trial of amifostine as a radioprotector in head and neck cancer.” J Clin Oncol 18, no. 19 (October 1, 2000): 3339–45. https://doi.org/10.1200/JCO.2000.18.19.3339.Full Text Link to Item
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Vujaskovic, Z., J. M. Poulson, A. A. Gaskin, D. E. Thrall, R. L. Page, H. C. Charles, J. R. MacFall, et al. “Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment.” Int J Radiat Oncol Biol Phys 46, no. 1 (January 1, 2000): 179–85. https://doi.org/10.1016/s0360-3016(99)00362-4.Full Text Link to Item
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Carter, D. L., M. E. Hebert, K. Smink, K. A. Leopold, R. L. Clough, and D. M. Brizel. “Double blind randomized trial of sucralfate vs placebo during radical radiotherapy for head and neck cancers.” Head Neck 21, no. 8 (December 1999): 760–66. https://doi.org/10.1002/(sici)1097-0347(199912)21:8<760::aid-hed12>3.0.co;2-#.Full Text Link to Item
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Brizel, D. M., R. K. Dodge, R. W. Clough, and M. W. Dewhirst. “Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome.” Radiother Oncol 53, no. 2 (November 1999): 113–17. https://doi.org/10.1016/s0167-8140(99)00102-4.Full Text Link to Item
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Prosnitz, L. R., P. Maguire, J. M. Anderson, S. P. Scully, J. M. Harrelson, E. L. Jones, M. Dewhirst, et al. “The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.” Int J Radiat Oncol Biol Phys 45, no. 4 (November 1, 1999): 941–49. https://doi.org/10.1016/s0360-3016(99)00272-2.Full Text Link to Item
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Brizel, D. M., K. Light, S. M. Zhou, and L. B. Marks. “Conformal radiation therapy treatment planning reduces the dose to the optic structures for patients with tumors of the paranasal sinuses.” Radiother Oncol 51, no. 3 (June 1999): 215–18. https://doi.org/10.1016/s0167-8140(99)00043-2.Full Text Link to Item
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Brizel, D. M. “Future directions in toxicity prevention.” Seminars in Radiation Oncology 8, no. 4 SUPPL. 1 (November 5, 1998): 17–20.
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Brizel, D. M. “Treatment of head and neck cancer - Reply.” New England Journal of Medicine 339, no. 18 (October 29, 1998): 1331–1331.Link to Item
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Evans, R. A. “Treatment of head and neck cancer.” N Engl J Med 339, no. 18 (October 29, 1998): 1330. https://doi.org/10.1056/NEJM199810293391814.Full Text Link to Item
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Brizel, D. M. “Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma.” Semin Radiat Oncol 8, no. 4 (October 1998): 237–46. https://doi.org/10.1016/s1053-4296(98)80021-0.Full Text Link to Item
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Brizel, D. M. “Future directions in toxicity prevention.” Semin Radiat Oncol 8, no. 4 Suppl 1 (October 1998): 17–20.Link to Item
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Brizel, D. M., M. E. Albers, S. R. Fisher, R. L. Scher, W. J. Richtsmeier, V. Hars, S. L. George, A. T. Huang, and L. R. Prosnitz. “Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer.” N Engl J Med 338, no. 25 (June 18, 1998): 1798–1804. https://doi.org/10.1056/NEJM199806183382503.Full Text Link to Item
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Bryce, T. J., M. W. Dewhirst, C. E. Floyd, V. Hars, and D. M. Brizel. “Artificial neural network model of survival in patients treated with irradiation with and without concurrent chemotherapy for advanced carcinoma of the head and neck.” Int J Radiat Oncol Biol Phys 41, no. 2 (May 1, 1998): 339–45. https://doi.org/10.1016/s0360-3016(98)00016-9.Full Text Link to Item
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Brizel, D. M. “Where there's smoke, is there fire?” Int J Hyperthermia 14, no. 6 (1998): 589–91. https://doi.org/10.3109/02656739809018257.Full Text Link to Item
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Bryce, T. J., M. W. Dewhirst, C. E. Floyd, V. Hars, and D. M. Brizel. “An artificial neural network predictive model of survival in patients treated for advanced carcinoma of the head and neck.” Radiology 205 (November 1, 1997): 1419–1419.Link to Item
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Prosnitz, L. R., D. M. Brizel, and K. L. Light. “Radiation techniques for the treatment of Hodgkin's disease with combined modality therapy or radiation alone.” Int J Radiat Oncol Biol Phys 39, no. 4 (November 1, 1997): 885–95. https://doi.org/10.1016/s0360-3016(97)00463-x.Full Text Link to Item
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Brizel, David M., and Mark W. Dewhirst. “Response to the Letter of Drs. Hartmann et al.” Radiation Research 148, no. 5 (November 1997): 524–524. https://doi.org/10.2307/3579328.Full Text
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Hartmann, K. A., A. J. Van der Kleij, C. J. Schneider, and P. Sminia. “Is hyperbaric oxygen more effective than carbogen/nicotinamide in tumor radiation response?” Radiat Res 148, no. 5 (November 1997): 523–25.Link to Item
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Nozue, M., I. Lee, F. Yuan, B. A. Teicher, D. M. Brizel, M. W. Dewhirst, C. G. Milross, et al. “Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.” J Surg Oncol 66, no. 1 (September 1997): 30–38. https://doi.org/10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o.Full Text Link to Item
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Bentel, G. C., L. B. Marks, K. Hendren, and D. M. Brizel. “Comparison of two head and neck immobilization systems.” Int J Radiat Oncol Biol Phys 38, no. 4 (July 1, 1997): 867–73. https://doi.org/10.1016/s0360-3016(97)00075-8.Full Text Link to Item
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Brizel, D. M., W. D. Hage, R. K. Dodge, M. T. Munley, C. A. Piantadosi, and M. W. Dewhirst. “Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.” Radiat Res 147, no. 6 (June 1997): 715–20.Link to Item
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Brizel, D. M., G. S. Sibley, L. R. Prosnitz, R. L. Scher, and M. W. Dewhirst. “Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck.” Int J Radiat Oncol Biol Phys 38, no. 2 (May 1, 1997): 285–89. https://doi.org/10.1016/s0360-3016(97)00101-6.Full Text Link to Item
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Bean, J. M., G. E. Archer, M. T. Munley, E. Ong, S. A. Snyder, Z. A. Haroon, R. E. McLendon, et al. “2013 The impact of hypoxia and oxygenation modification on the radiation response of an intracranial rat glioma.” International Journal of Radiation Oncology*Biology*Physics 39, no. 2 (January 1997): 247–247. https://doi.org/10.1016/s0360-3016(97)80782-1.Full Text
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Brizel, David M., Kim Light, Su-Min Zhou, and Lawrence B. Marks. “1050 Conformal 3-D radiation therapy treatment planning reduces the dose to the optic structures for patients with tumors of the paranasal sinuses.” International Journal of Radiation Oncology*Biology*Physics 39, no. 2 (January 1997): 240–240. https://doi.org/10.1016/s0360-3016(97)80768-7.Full Text
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Brizel, D. M., S. P. Scully, J. M. Harrelson, L. J. Layfield, R. K. Dodge, H. C. Charles, T. V. Samulski, L. R. Prosnitz, and M. W. Dewhirst. “Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.” Cancer Res 56, no. 23 (December 1, 1996): 5347–50.Link to Item
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Jones, D. N., G. B. McCowage, H. D. Sostman, D. M. Brizel, L. Layfield, H. C. Charles, M. W. Dewhirst, et al. “Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.” J Nucl Med 37, no. 9 (September 1996): 1438–44.Link to Item
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Dewhirst, M. W., E. T. Ong, G. L. Rosner, S. W. Rehmus, S. Shan, R. D. Braun, D. M. Brizel, and T. W. Secomb. “Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.” Br J Cancer Suppl 27 (July 1996): S241–46.Link to Item
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Brizel, D. M., S. P. Scully, J. M. Harrelson, L. J. Layfield, J. M. Bean, L. R. Prosnitz, and M. W. Dewhirst. “Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.” Cancer Res 56, no. 5 (March 1, 1996): 941–43.Link to Item
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BRIZEL, D. M. “Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.” Cancer Res. 56 (1996): 941–43.
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Dewhirst, M. W., E. T. Ong, G. L. Rosner, S. W. Rehmus, S. Shan, R. D. Braun, D. M. Brizel, and T. W. Secomb. “Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content.” British Journal of Cancer 74, no. SUPPL. XXVII (January 1, 1996).
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Brizel, D. M., S. Lin, J. L. Johnson, J. Brooks, M. W. Dewhirst, and C. A. Piantadosi. “The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.” Br J Cancer 72, no. 5 (November 1995): 1120–24. https://doi.org/10.1038/bjc.1995.474.Full Text Link to Item
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Brizel, D. M., G. L. Rosner, L. R. Prosnitz, and M. W. Dewhirst. “Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases.” Int J Radiat Oncol Biol Phys 32, no. 4 (July 15, 1995): 1121–25. https://doi.org/10.1016/0360-3016(95)00106-9.Full Text Link to Item
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Brizel, D. M., R. Dodge, and M. W. Dewhirst. “The effect of the perflubron emulsion Oxygent on the calibration characteristics of polarographic oxygen electrodes.” Radiother Oncol 33, no. 3 (December 1994): 262–65. https://doi.org/10.1016/0167-8140(94)90362-x.Full Text Link to Item
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Brizel, D. M., G. L. Rosner, J. Harrelson, L. R. Prosnitz, and M. W. Dewhirst. “Pretreatment oxygenation profiles of human soft tissue sarcomas.” Int J Radiat Oncol Biol Phys 30, no. 3 (October 15, 1994): 635–42. https://doi.org/10.1016/0360-3016(92)90950-m.Full Text Link to Item
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Lachance, D. H., D. M. Brizel, J. P. Gockerman, E. C. Halperin, P. C. Burger, O. B. Boyko, M. T. Brown, and S. C. Schold. “Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.” Neurology 44, no. 9 (September 1994): 1721–27. https://doi.org/10.1212/wnl.44.9.1721.Full Text Link to Item
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Brizel, D. M., J. P. Gockerman, J. Crawford, J. W. Hathorn, J. O. Moore, B. Osborne, and L. R. Prosnitz. “A pilot study of etoposide, vinblastine, and doxorubicin plus involved field irradiation in advanced, previously untreated Hodgkin's disease.” Cancer 74, no. 1 (July 1, 1994): 159–63. https://doi.org/10.1002/1097-0142(19940701)74:1<159::aid-cncr2820740125>3.0.co;2-x.Full Text Link to Item
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JONES, D. N., D. M. BRIZEL, H. C. CHARLES, M. W. DEWHIRST, H. S. FRIEDMAN, G. MCCOWAGE, D. M. PRESCOTT, H. D. SOSTMAN, and R. E. COLEMAN. “MONITORING OF RESPONSE TO NEOADJUVANT THERAPY OF SOFT-TISSUE AND MUSCULOSKELETAL SARCOMAS USING F-18-FDG PET.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P38–P38.Link to Item
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Brizel, D. M., K. A. Leopold, S. R. Fisher, T. J. Panella, R. L. Fine, C. L. Bedrosian, P. D. Kenan, A. Huang, T. Womack, and T. Bjurstrom. “A phase I/II trial of twice daily irradiation and concurrent chemotherapy for locally advanced squamous cell carcinoma of the head and neck.” Int J Radiat Oncol Biol Phys 28, no. 1 (January 1, 1994): 213–20. https://doi.org/10.1016/0360-3016(94)90160-0.Full Text Link to Item
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Kavanagh, B. D., D. M. Brizel, K. A. Leopold, and J. C. Acker. “Radiation therapy for head and neck cancer in a patient with Takayasu's arteritis.” Acta Oncol 33, no. 1 (1994): 73–74. https://doi.org/10.3109/02841869409098382.Full Text Link to Item
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Berlangieri, S. U., D. M. Brizel, R. L. Scher, T. Schifter, T. C. Hawk, S. Hamblen, R. E. Coleman, and J. M. Hoffman. “Pilot study of positron emission tomography in patients with advanced head and neck cancer receiving radiotherapy and chemotherapy.” Head Neck 16, no. 4 (1994): 340–46. https://doi.org/10.1002/hed.2880160408.Full Text Link to Item
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Brizel, D. M., B. Klitzman, J. M. Cook, J. Edwards, G. Rosner, and M. W. Dewhirst. “A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model.” Int J Radiat Oncol Biol Phys 25, no. 2 (January 15, 1993): 269–76. https://doi.org/10.1016/0360-3016(93)90348-y.Full Text Link to Item
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Dewhirst, M. W., E. T. Ong, D. Madwed, B. Klitzman, T. Secomb, D. Brizel, J. Bonaventura, G. Rosner, B. Kavanagh, and J. Edwards. “Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature.” Radiat Res 132, no. 1 (October 1992): 61–68.Link to Item
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Dewhirst, M. W., E. T. Ong, B. Klitzman, T. W. Secomb, R. Z. Vinuya, R. Dodge, D. Brizel, and J. F. Gross. “Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.” Radiat Res 130, no. 2 (May 1992): 171–82.Link to Item
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Halperin, E. C., D. M. Brizel, G. Honore, M. R. Sontag, O. W. Griffith, D. D. Bigner, and H. S. Friedman. “The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.” Int J Radiat Oncol Biol Phys 24, no. 1 (1992): 103–9. https://doi.org/10.1016/0360-3016(92)91028-l.Full Text Link to Item
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Halperin, E. C., D. M. Brizel, G. Honore, M. R. Sontag, O. W. Griffith, D. D. Bigner, and H. S. Friedman. “The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.” International Journal of Radiation Oncology, Biology, Physics 24, no. 1 (1992): 103–9.
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Brizel, D. M., E. P. Winer, L. R. Prosnitz, J. Scott, J. Crawford, J. O. Moore, and J. P. Gockerman. “Improved survival in advanced Hodgkin's disease with the use of combined modality therapy.” Int J Radiat Oncol Biol Phys 19, no. 3 (September 1990): 535–42. https://doi.org/10.1016/0360-3016(90)90478-3.Full Text Link to Item
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BRIZEL, D. M. “CORRECTION.” International Journal of Radiation Oncology Biology Physics 15, no. 5 (November 1, 1988): 1258–1258.Link to Item
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Brizel, D. M., H. Weinstein, M. Hunt, and N. J. Tarbell. “Failure patterns and survival in pediatric soft tissue sarcoma.” Int J Radiat Oncol Biol Phys 15, no. 1 (July 1988): 37–41. https://doi.org/10.1016/0360-3016(88)90344-6.Full Text Link to Item
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Book Sections
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Yoo, D. S., and D. M. Brizel. “Translational research in head and neck oncology.” In Head and Neck Cancer: Multimodality Management, Second Edition, 215–27, 2016. https://doi.org/10.1007/978-3-319-27601-4_11.Full Text
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Conference Papers
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Marley, H., Y. M. Mowery, Q. Wu, and D. M. Brizel. “Utilization of 18FDG-PET-Based IMRT Planning to Spare the Most Metabolically Active Subvolume of Parotid Glands During Definitive Radiation Therapy for Head and Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 102:S101–2. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.06.260.Full Text
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Rodrigues, A., C. Wang, Q. Wu, D. Limon, Y. M. Mowery, D. Niedzwiecki, and D. M. Brizel. “Adaptive IMRT Planning Improves Pharyngeal Sparing for Oropharyngeal Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 102:e290–e290. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2018.07.922.Full Text
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Carpenter, D. J., Y. M. Mowery, G. Broadwater, A. Rodrigues, A. J. Wisdom, R. W. Clough, and D. M. Brizel. “The Risk of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 100:1395–1395. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2017.12.226.Full Text
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Mowery, Y. M., D. M. Brizel, J. P. Chino, and H. Moss. “Reduced Uninsured Rates and Racial Disparities in Insurance Coverage for Head and Neck Cancer Patients After Medicaid Expansion.” In International Journal of Radiation Oncology*Biology*Physics, 100:1349–1349. Elsevier BV, 2018. https://doi.org/10.1016/j.ijrobp.2017.12.113.Full Text
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Carpenter, D. J., G. Broadwater, Y. M. Mowery, A. Rodrigues, A. J. Wisdom, R. W. Clough, and D. M. Brizel. “The Incidence of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 99:E326–27. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.1381.Full Text
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Mowery, Y. M., I. Vergalasova, D. S. Yoo, D. Limon, S. K. Das, W. Y. Hara, and D. M. Brizel. “F-18-FDG PET/CT Response at 20 Gy Predicts Treatment Outcome for Head and Neck Squamous Cell Carcinoma (HNSCC).” In International Journal of Radiation Oncology Biology Physics, 96:E378–E378, 2016.Link to Item
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Mowery, Y. M., I. Vergalasova, D. S. Yoo, S. K. Das, W. Hara, and D. M. Brizel. “Correlating Clinical Outcomes With Changes in Tumor Volume and 18F-FDG PET Characteristics During Radiation Therapy for Head and Neck Squamous Cell Carcinoma (HNSCC).” In International Journal of Radiation Oncology*Biology*Physics, 94:920–920. Elsevier BV, 2016. https://doi.org/10.1016/j.ijrobp.2015.12.164.Full Text
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Mowery, Y. M., I. Vergalasova, D. S. Yoo, S. K. Das, and D. M. Brizel. “Correlating Outcomes With Changes in Tumor Volume and 18F-FDG PET Characteristics During Radiation Therapy for Head and Neck Squamous Cell Carcinoma (HNSCC).” In International Journal of Radiation Oncology*Biology*Physics, 93:E336–E336. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.1403.Full Text
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Cramer, C. K., M. Palta, P. Patel, and D. M. Brizel. “Ipsilateral Tonsil Chemoradiation: Improved Toxicity Compared to Bilateral Radiation and Effective Rates of Local-Regional Control.” In International Journal of Radiation Oncology*Biology*Physics, 88:477–477. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.053.Full Text
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Das, S. K., A. Kim, D. S. Yoo, J. K. Hoang, and D. M. Brizel. “The Impact of Intrinsic Glucose Uptake Variability on Voxel-Based Assessment of FDG-PET Radiation Therapy (RT) Response in Head-and-Neck Cancer (HNC) Patients.” In International Journal of Radiation Oncology*Biology*Physics, 88:513–513. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.156.Full Text
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Dewhirst, M. W., K. Ashcraft, I. Batinic-Haberle, I. Spasojevic, and D. M. Brizel. “A Novel Mnsod Mimic Widens the Therapeutic Margin by Simultaneously Radioprotecting Normal Tissue and Radiosensitizing Tumor.” In International Journal of Radiation Oncology*Biology*Physics, 88:468–468. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.028.Full Text
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Kim, A., S. Das, K. R. Choudhury, K. Temple, and D. M. Brizel. “Treatment Planning Using FDG-PET to Optimize Parotid Gland Sparing Before and During Chemoradiation for Head-and-Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 88:499–499. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.116.Full Text
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Lee, W. T., R. Medinas, J. H. Lee, S. Sparks, D. M. Brizel, R. M. Esclamado, N. Ready, and K. J. Weinhold. “Impact of Concurrent Chemoradiation on T Cell Populations in Patients With Advanced-Stage Oropharyngeal Squamous Cell Carcinoma.” In International Journal of Radiation Oncology*Biology*Physics, 88:504–504. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2013.11.131.Full Text
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Kim, A., S. Das, R. Kingshuk, K. Temple, D. Yoo, and D. M. Brizel. “Adaptive Treatment Planning With F-18 FDG-PET and CT Scans to Optimize Parotid Sparing in Head-and-Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 87:S459–60. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.1214.Full Text
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Patel, P. R., M. Palta, R. Clough, D. Yoo, and D. M. Brizel. “Reduced Volume Irradiation for Head-and-Neck Cancer of Unknown Primary (HNCUP).” In International Journal of Radiation Oncology*Biology*Physics, 87:S482–S482. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.1275.Full Text
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Rankine, L., J. Bowsher, D. Brizel, F. Yin, and S. Das. “SU‐E‐J‐200: Impact of FDG‐PET/CT Reconstruction Parameters On PET Variability and Treatment Response Assessment.” In Medical Physics, 40:197, 2013. https://doi.org/10.1118/1.4814412.Full Text
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Craciunescu, O. I., D. S. Yoo, J. D. Onxley, S. K. Das, N. Muradyan, E. Gu, J. Hoang, and D. M. Brizel. “Quantifying Temporal Fluctuations of DCE-MRI Extracted Parameters in Neck Nodal Metastases.” In International Journal of Radiation Oncology*Biology*Physics, 84:S755–S755. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.2021.Full Text
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Das, S. K., J. K. Hoang, K. R. Choudhury, B. Peterson, D. S. Yoo, and D. M. Brizel. “The Role of Intrinsic Fluctuation in Glucose Metabolism in the Use of FDG-PET in Assessing Metabolic Response to Chemoradiation in Head-and-Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 84:S525–S525. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.1401.Full Text
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Das, S., J. Hoang, K. R. Choudhury, D. Yoo, and D. Brizel. “WE‐A‐217A‐02: The Impact of Fluorodeoxyglucose Positron Emission Tomography (FDG‐PET) Variability on the Assessment of Treatment Response in Head‐And‐Neck Cancer Patients Undergoing Chemoradiotherapy.” In Medical Physics, 39:3935–36, 2012. https://doi.org/10.1118/1.4736060.Full Text
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Dorth, J. A., and D. M. Brizel. “Incidence of Asymptomatic Carotid Artery Stenosis in Survivors of Head and Neck Radiation.” In International Journal of Radiation Oncology*Biology*Physics, 81:S76–S76. Elsevier BV, 2011. https://doi.org/10.1016/j.ijrobp.2011.06.152.Full Text
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Yoo, S., S. Das, Q. wu, D. Brizel, and F. Yin. “SU‐GG‐T‐136: Treatment Plans Comparison with Static‐Gantry IMRT and RapidArcTM for Head‐And‐Neck Cancers Involving Cervical Lymph Nodes.” In Medical Physics, 37:3216, 2010. https://doi.org/10.1118/1.3468526.Full Text
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Brizel, D. M., D. S. Yoo, N. Ready, J. P. Kirkpatrick, M. W. Dewhirst, R. L. Scher, E. Cleland, J. MacFall, D. Barboriak, and O. Craciunescu. “Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 75:S175–76. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.409.Full Text
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Higgins, K. A., J. K. Hoang, J. P. Chino, and D. M. Brizel. “Prognostic Value of Pre- and Post-treatment FDG PET in Head-and-Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 75:S18–S18. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.064.Full Text
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Ren, L., J. Zhang, D. Thongphiew, Q. Wu, H. Yan, D. M. Brizel, W. R. Lee, C. G. Willett, and F. Yin. “Development and Clinical Evaluation of a Novel 3D Digital Tomosynthesis (DTS) Reconstruction Method using a Deformation Field Map.” In International Journal of Radiation Oncology*Biology*Physics, 75:S96–S96. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.236.Full Text
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Rosenthal, D. I., C. D. Fuller, K. K. Ang, D. M. Brizel, A. Eisbruch, Q. T. Le, N. Y. Lee, B. O’Sullivan, J. Duppen, and C. R. N. Rasch. “Pre- and Postinduction Chemotherapy Target Volume Delineation in Head and Neck Cancer: Preliminary Results from an Expert Panel.” In International Journal of Radiation Oncology*Biology*Physics, 75:S431–S431. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.987.Full Text
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Yoo, S., S. Das, Q. wu, D. Brizel, D. Yoo, and F. Yin. “SU‐FF‐T‐130: Radiotherapy Treatment Plans with RapidArc for Head‐And‐Neck Cancer.” In Medical Physics, 36:2549–50, 2009. https://doi.org/10.1118/1.3181604.Full Text
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Craciunescu, O. I., D. Yoo, E. W. Cleland, D. P. Barboriak, M. Dolguikh, N. Muradyan, M. Kasibhatla, M. Carroll, and D. M. Brizel. “Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) Assessment of Tumor Physiology in Head and Neck Cancer: A Comparison of Intra Patient and Inter Patient Variability.” In International Journal of Radiation Oncology*Biology*Physics, 72:S594–95. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.204.Full Text
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Gilliard, L. M., T. Gosselin, J. J. Meyer, R. Clough, and D. M. Brizel. “Impact of Interventions by a Registered Dietitian on Nutritional Outcomes in Head and Neck Cancer Patients Undergoing Radiotherapy.” In International Journal of Radiation Oncology*Biology*Physics, 72:S404–S404. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.1292.Full Text
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Yoo, D. S., O. Craciunescu, E. Cleland, D. Barboriak, N. Muradyan, M. Dolguikh, J. P. Kirkpatrick, M. D. Carroll, and D. M. Brizel. “Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) to Assess Changes in Tumor Physiology Caused by Molecular Targeted Agents in Locally Advanced Head and Neck Cancer (LAHNC).” In International Journal of Radiation Oncology*Biology*Physics, 72:S160–S160. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.504.Full Text
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Cleland, E., D. Brizel, D. Yoo, M. Dolguikh, N. Muradyan, D. Barboriak, and O. Craciunescu. “SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors.” In Medical Physics, 35:2721, 2008. https://doi.org/10.1118/1.2961730.Full Text
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Kasibhatla, M., L. R. Prosnitz, S. R. Fisher, R. L. Scher, R. Clough, and D. M. Brizel. “Hyperfractionated Radiotherapy Versus Hyperfractionated Radiotherapy and Concomitant Chemotherapy in Locally Advanced Head and Neck Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 69:S11–12. Elsevier BV, 2007. https://doi.org/10.1016/j.ijrobp.2007.07.022.Full Text
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Craciunescu, O., N. Muradyan, D. Barboriak, J. Macfall, and D. Brizel. “TH‐E‐M100J‐02: Potential of Dynamic Contrast Enhanced‐Magnetic Resonance Imaging (DCE‐MRI) Extracted Parameters to Estimate Treatment Response in Locally Advanced Head and Neck (LAHN) Cancer Patients.” In Medical Physics, 34:2649, 2007. https://doi.org/10.1118/1.2761755.Full Text
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Bourhis, J., H. Tribodet, D. M. Brizel, B. Movsas, J. Buntzel, R. Komaki, S. S. Leong, P. Levendag, and J. P. Pignon. “117.” In International Journal of Radiation Oncology*Biology*Physics, 66:S67–S67. Elsevier BV, 2006. https://doi.org/10.1016/j.ijrobp.2006.07.148.Full Text
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Wu, Q., D. J. Godfrey, Z. Wang, S. Yoo, D. M. Brizel, and F. Yin. “1025.” In International Journal of Radiation Oncology*Biology*Physics, 66:S143–44. Elsevier BV, 2006. https://doi.org/10.1016/j.ijrobp.2006.07.289.Full Text
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Isitt, J., B. A. Murphy, J. L. Beaumont, A. S. Garden, C. K. Gwede, A. Trotti, R. F. Meredith, J. B. Epstein, Q. Le, and D. M. Brizel. “Oral mucositis (OM) related morbidity and resource utilization in a prospective study of head and neck cancer (HNC) patients.” In Journal of Clinical Oncology, 24:289S-289S. AMER SOC CLINICAL ONCOLOGY, 2006.Link to Item
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Brizel, D. M. “38 Clinical status of keratinocyte growth factor.” In Radiotherapy and Oncology, 78:S14–S14. Elsevier BV, 2006. https://doi.org/10.1016/s0167-8140(06)80532-3.Full Text
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Craciunescu, O., T. Raidy, D. Brizel, K. Blackwell, Z. Vujaskovic, T. Wong, E. Jones, N. Larrier, J. Macfall, and M. Dewhirst. “SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites.” In Medical Physics, 33:2049, 2006. https://doi.org/10.1118/1.2240901.Full Text
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Gosselin, T. K., K. A. Raj, R. W. Clough, and D. M. Brizel. “Amifostine for Xerostomia - Normal Tissue Protection at What Cost?” In International Journal of Radiation Oncology*Biology*Physics, 63:S128–S128. Elsevier BV, 2005. https://doi.org/10.1016/j.ijrobp.2005.07.218.Full Text
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Brizel, D. M., and T. Wasserman. “The influence of intravenous amifostine on xerostomia and survival during radiotherapy for head and neck cancer: Two year follow-up of a prospective randomized trial.” In Journal of Clinical Oncology, 22:497S-497S. AMER SOC CLINICAL ONCOLOGY, 2004.Link to Item
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Brizel, D. M. “Human tumor oxygenation: The Duke University Medical Center experience.” In Tumor Hypoxia, edited by V. Vaupel and D. K. Kelleher, 29–38. WISSENSCHAFTLICHE verlagsgesellschaft mbh, 1999.Link to Item
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Brizel, D. M. “Future directions in toxicity prevention.” In Seminars in Radiation Oncology, 8:17–20, 1998.
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DeGrado, T. R., D. M. Brizel, C. J. McKinney, and R. E. Coleman. “Estimation of perfusion and oxygen utilization rate in tumors with PET: A technique without arterial blood sampling.” In Journal of Nuclear Medicine, 39:107P-107P. SOC NUCLEAR MEDICINE INC, 1998.Link to Item
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Carter, D. L., M. E. Hebert, K. L. Leopold, and D. M. Brizel. “1037 Double blind randomized trial of sucralfate vs. Placebo during a course of radical radiotherapy for head and neck squamous carcinoma.” In International Journal of Radiation Oncology*Biology*Physics, 39:234–234. Elsevier BV, 1997. https://doi.org/10.1016/s0360-3016(97)80756-0.Full Text
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