Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Fellowship, Metabolism, Endocrinology And Nutrition, University of Washington, School of Medicine 1987 - 1990
  • Resident, Temple University, School of Medicine 1983 - 1986
  • M.D., University of Wisconsin - Madison 1983
• 

  Duke Appointment History

  • Instructor Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2014 - 2015
• Research
• 

  Selected Grants

  • Novel metabolic actions of GIP awarded by National Institutes of Health 2020 - 2025
  • North Carolina Diabetes Research Center (NCDRC) awarded by Wake Forest University School Of Medicine 2020 - 2025
  • Mechanisms of insulin secretion mediated by alpha cells awarded by National Institutes of Health 2019 - 2024
  • Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2019 - 2024
  • Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents awarded by National Institutes of Health 2018 - 2022
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • IPA - Cris Slentz awarded by Durham Veterans Affairs Medical Center 2019 - 2021
  • IPA - Lorraine Elliott-Penry awarded by Durham Veterans Affairs Medical Center 2019 - 2021
  • IPA - Lucy Piner awarded by Durham Veterans Affairs Medical Center 2019 - 2021
  • IPA - Radha Krishna awarded by Durham Veterans Affairs Medical Center 2019 - 2021
  • IPA-Leslie Kelly awarded by Durham Veterans Affairs Medical Center 2019 - 2021
  • The Role of Islet DPP4 for Regulation of Glucose Homeostasis awarded by National Institutes of Health 2018 - 2021
  • Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
  • INCRETIN ACTION IN PHYSIOLOGY AND DIABETES awarded by National Institutes of Health 2014 - 2021
  • Nutrient-dependent action of glucagon and GLP-1 in glucose metabolism and insulin secretion awarded by National Institutes of Health 2019 - 2020
  • A multi-center, randomized, double-blind, parallel-group, multiple dose, adaptive study assessing the pharmacokinetics, pharmacodynamics, safety and tolerability of TTP399 in adult patients with type 1 diabetes mellitus. awarded by vTv Therapeutics LLC 2018 - 2020
  • Assessing the Role of Glucose-Dependent Insulinotropic Polypeptide to Mediate Improved Beta-Cell Function Following Bariatric Surgery awarded by National Institutes of Health 2017 - 2019
  • Role of Islet GLP-1 and DPP-4 in Insulin Secretion awarded by Merck Sharp & Dohme 2015 - 2019
  • IPA - Andrew Hoselton awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • IPA - Cris Slentz awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • IPA - Lorraine Elliott-Penry awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • IPA - Lucy Piner awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • IPA - Radha Krishna awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • IPA- Leslie Kelly awarded by Durham Veterans Affairs Medical Center 2017 - 2019
  • Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
  • The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes awarded by National Institutes of Health 2013 - 2019
  • The Role of Vitamin D in Established Type 2 Diabetes awarded by Tufts Medical Center 2015 - 2018
  • A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety and Efficacy of LGD-6972 in Patients with Type 2 Diabetes Mellitus awarded by Ligand Pharmaceuticals, Inc. 2016 - 2017
  • The Role of Glucagon in Diabetic Ketoacidosis awarded by Endocrine Fellows Foundation 2016 - 2017
• 

  External Relationships

  • American Diabetes Association
  • Eli Lilly & Co.
  • Endocrine Society
  • Intarcia Therapeutics, Inc.
  • Merck Sharpe & Dohme (Merck & Co, USA)
  • Sun Pharmaceuticals
  • The Endocrine Society
  • ansh labs
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Kirk, S., B. Brehm, B. E. Saelens, J. G. Woo, E. Kissel, D. D’Alessio, C. Bolling, and S. R. Daniels. Role of carbohydrate modification in weight management among obese children: A randomized clinical trial. Vol. 109, 2014. https://doi.org/10.1159/000356352.
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  • Academic Articles

    • Willard, Francis S., Jonathan D. Douros, Maria Bn Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, et al. “Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.” Jci Insight 5, no. 17 (September 3, 2020). https://doi.org/10.1172/jci.insight.140532.
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    • Gray, Sarah M., Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, et al. “Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.” J Biol Chem 295, no. 33 (August 14, 2020): 11529–41. https://doi.org/10.1074/jbc.RA120.014368.
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    • Buse, John B., Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D’Alessio, and Melanie J. Davies. “Erratum. 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2020;43:487-493.” Diabetes Care 43, no. 7 (July 2020): 1670. https://doi.org/10.2337/dc20-er07.
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    • Brehm, Bonnie, Suzanne Summer, Todd Jenkins, David D’Alessio, and Thomas Inge. “Thermic effect of food and resting energy expenditure after sleeve gastrectomy for weight loss in adolescent females.” Surg Obes Relat Dis 16, no. 5 (May 2020): 599–606. https://doi.org/10.1016/j.soard.2020.01.025.
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    • Capozzi, Megan E., Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, et al. “The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.” Diabetes 69, no. 5 (May 2020): 882–92. https://doi.org/10.2337/db19-1216.
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    • Aulinger, Benedikt A., Marta Perabo, Randy J. Seeley, Klaus G. Parhofer, and David A. D’Alessio. “Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats.” Am J Physiol Endocrinol Metab 318, no. 2 (February 1, 2020): E189–97. https://doi.org/10.1152/ajpendo.00298.2019.
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    • Buse, John B., Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A. D’Alessio, and Melanie J. Davies. “2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).” Diabetologia 63, no. 2 (February 2020): 221–28. https://doi.org/10.1007/s00125-019-05039-w.
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    • Herbst, Rebecca A., Onala T. Telford, John Hunting, W Michael Bullock, Erin Manning, Beatrice D. Hong, David A. D’Alessio, and Tracy L. Setji. “THE EFFECTS OF PERIOPERATIVE DEXAMETHASONE ON GLYCEMIC CONTROL AND POSTOPERATIVE OUTCOMES.” Endocr Pract 26, no. 2 (February 2020): 218–25. https://doi.org/10.4158/EP-2019-0252.
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    • Svendsen, Berit, Megan E. Capozzi, Jingjing Nui, Sarah A. Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A. D’Alessio, and Jonathan E. Campbell. “Pharmacological antagonism of the incretin system protects against diet-induced obesity.” Mol Metab 32 (February 2020): 44–55. https://doi.org/10.1016/j.molmet.2019.11.018.
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    • Pettus, Jeremy H., David D’Alessio, Juan P. Frias, Eric G. Vajda, James D. Pipkin, Julio Rosenstock, Gretchen Williamson, Miriam A. Zangmeister, Lin Zhi, and Keith B. Marschke. “Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study.” Diabetes Care 43, no. 1 (January 2020): 161–68. https://doi.org/10.2337/dc19-1328.
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    • Müller, T. D., B. Finan, S. R. Bloom, D. D’Alessio, D. J. Drucker, P. R. Flatt, A. Fritsche, et al. “Glucagon-like peptide 1 (GLP-1).” Mol Metab 30 (December 2019): 72–130. https://doi.org/10.1016/j.molmet.2019.09.010.
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    • Angellotti, Edith, David D’Alessio, Bess Dawson-Hughes, Yan Chu, Jason Nelson, Peter Hu, Robert M. Cohen, and Anastassios G. Pittas. “Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.” Clin Nutr 38, no. 5 (October 2019): 2449–53. https://doi.org/10.1016/j.clnu.2018.10.003.
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    • Douros, Jonathan D., Jenny Tong, and David A. D’Alessio. “The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control.” Endocr Rev 40, no. 5 (October 1, 2019): 1394–1423. https://doi.org/10.1210/er.2018-00183.
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    • Douros, Jonathan D., Jingjing Niu, Sophia Sdao, Trillian Gregg, Matthew J. Merrins, Jonathan Campbell, Jenny Tong, and David D’Alessio. “Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control.” Mol Metab 28 (October 2019): 144–50. https://doi.org/10.1016/j.molmet.2019.07.003.
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    • Herman, Mark A., Jonathan E. Campbell, and David A. D’Alessio. “One small step for mice, one giant leap for GWAS?” J Clin Invest 129, no. 10 (October 1, 2019): 4083–85. https://doi.org/10.1172/JCI131650.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery.” Gut 68, no. 10 (October 2019): 1838–45. https://doi.org/10.1136/gutjnl-2018-317760.
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    • Capozzi, Megan E., Jacob B. Wait, Jepchumba Koech, Andrew N. Gordon, Reilly W. Coch, Berit Svendsen, Brian Finan, David A. D’Alessio, and Jonathan E. Campbell. “Glucagon lowers glycemia when β-cells are active.” Jci Insight 5 (July 23, 2019). https://doi.org/10.1172/jci.insight.129954.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia.” Diabetes Obes Metab 21, no. 6 (June 2019): 1513–17. https://doi.org/10.1111/dom.13676.
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    • Davies, Melanie J., David A. D’Alessio, Judith Fradkin, Walter N. Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J. Wexler, and John B. Buse. “Correction to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).” Diabetologia 62, no. 5 (May 2019): 873. https://doi.org/10.1007/s00125-019-4845-x.
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    • Myers, Martin G., and Martin G. Diabetes Editorial Team. “Diabetes Takes New Steps to Increase Transparency and Reproducibility.” Diabetes 68, no. 4 (April 2019): 681–82. https://doi.org/10.2337/dbi19-0008.
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    • Douros, Jonathan D., Jingjing Niu, Sophia Sdao, Trillian Gregg, Kelsey Fisher-Wellman, Manish Bharadwaj, Anthony Molina, et al. “Sleeve gastrectomy rapidly enhances islet function independently of body weight.” Jci Insight 4, no. 6 (March 21, 2019). https://doi.org/10.1172/jci.insight.126688.
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    • Capozzi, Megan E., Berit Svendsen, Sara E. Encisco, Sophie L. Lewandowski, Mackenzie D. Martin, Haopeng Lin, Justin L. Jaffe, et al. “β Cell tone is defined by proglucagon peptides through cAMP signaling.” Jci Insight 4, no. 5 (March 7, 2019). https://doi.org/10.1172/jci.insight.126742.
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    • Shariff, Afreen Idris, Sohail Syed, Rebecca A. Shelby, Jeremy Force, Jeffrey Melson Clarke, David D’Alessio, and Leonor Corsino. “Novel cancer therapies and their association with diabetes.” J Mol Endocrinol 62, no. 2 (February 1, 2019): R187–99. https://doi.org/10.1530/JME-18-0002.
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    • Coskun, Tamer, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, et al. “LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.” Mol Metab 18 (December 2018): 3–14. https://doi.org/10.1016/j.molmet.2018.09.009.
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    • Davies, Melanie J., David A. D’Alessio, Judith Fradkin, Walter N. Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J. Wexler, and John B. Buse. “Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).” Diabetologia 61, no. 12 (December 2018): 2461–98. https://doi.org/10.1007/s00125-018-4729-5.
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    • Davies, Melanie J., David A. D’Alessio, Judith Fradkin, Walter N. Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J. Wexler, and John B. Buse. “Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).” Diabetes Care 41, no. 12 (December 2018): 2669–2701. https://doi.org/10.2337/dci18-0033.
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    • Rivero-Gutierrez, Belen, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D’Alessio, and Diego Perez-Tilve. “Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.” Mol Metab 17 (November 2018): 28–38. https://doi.org/10.1016/j.molmet.2018.07.012.
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    • Page, Laura C., Amalia Gastaldelli, Sarah M. Gray, David A. D’Alessio, and Jenny Tong. “Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.” Diabetes 67, no. 10 (October 2018): 1976–85. https://doi.org/10.2337/db18-0451.
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    • Buse, John B., David A. D’Alessio, and Matthew C. Riddle. “Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes?” Diabetes Care 41, no. 8 (August 2018): 1560–62. https://doi.org/10.2337/dci18-0025.
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    • Douros, Jonathan D., Alfor G. Lewis, Eric P. Smith, JingJing Niu, Megan Capozzi, April Wittmann, Jonathan Campbell, et al. “Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.” Diabetes 67, no. 8 (August 2018): 1504–11. https://doi.org/10.2337/db18-0081.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.” Diabetes Obes Metab 20, no. 4 (April 2018): 872–78. https://doi.org/10.1111/dom.13165.
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    • Nunez, Derek J., and David D’Alessio. “Glucagon receptor as a drug target: A witches' brew of eye of newt (peptides) and toe of frog (receptors).” Diabetes Obes Metab 20, no. 2 (February 2018): 233–37. https://doi.org/10.1111/dom.13102.
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    • Angellotti, E., D. D’Alessio, B. Dawson-Hughes, J. Nelson, R. M. Cohen, A. Gastaldelli, and A. G. Pittas. “Vitamin D supplementation in patients with type 2 diabetes: The vitamin D for established type 2 diabetes (DDM2) study.” Journal of the Endocrine Society 2, no. 4 (January 1, 2018): 310–21. https://doi.org/10.1210/JS.2018-00015.
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    • Crowley, Matthew J., John W. Williams, Andrzej S. Kosinski, David A. D’Alessio, and John B. Buse. “Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.” Diabetes Care 40, no. 12 (December 2017): 1787–89. https://doi.org/10.2337/dc17-1528.
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    • Elder, Deborah A., Lindsey N. Hornung, Jane C. Khoury, and David A. D’Alessio. “β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes.” J Adolesc Health 61, no. 6 (December 2017): 703–8. https://doi.org/10.1016/j.jadohealth.2017.06.007.
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    • Jessen, Lene, Eric P. Smith, Yvonne Ulrich-Lai, James P. Herman, Randy J. Seeley, Darleen Sandoval, and David D’Alessio. “Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats.” Endocrinology 158, no. 7 (July 1, 2017): 2124–33. https://doi.org/10.1210/en.2016-1826.
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    • Chambers, Adam P., Joyce E. Sorrell, April Haller, Karen Roelofs, Chelsea R. Hutch, Ki-Suk Kim, Ruth Gutierrez-Aguilar, et al. “The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.” Cell Metab 25, no. 4 (April 4, 2017): 927-934.e3. https://doi.org/10.1016/j.cmet.2017.02.008.
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    • Campbell, Jonathan E., and David A. D’Alessio. “DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.” J Clin Invest 127, no. 3 (March 1, 2017): 793–95. https://doi.org/10.1172/JCI92845.
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    • Zhang, Cecilia J., Martin Bidlingmaier, Mekibib Altaye, Laura C. Page, David D’Alessio, Matthias H. Tschöp, and Jenny Tong. “Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.” Eur J Endocrinol 176, no. 2 (February 2017): 123–32. https://doi.org/10.1530/EJE-16-0789.
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    • Ghosal, Sriparna, Amy E. B. Packard, Parinaz Mahbod, Jessica M. McKlveen, Randy J. Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P. Smith, David A. D’Alessio, and James P. Herman. “Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.” J Neurosci 37, no. 1 (January 4, 2017): 184–93. https://doi.org/10.1523/JNEUROSCI.1104-16.2016.
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    • Cefalu, William T., Andrew J. M. Boulton, William V. Tamborlane, Robert G. Moses, Derek LeRoith, Eddie L. Greene, Frank B. Hu, et al. “Diabetes Care: "Taking It to the Limit One More Time".” Diabetes Care 40, no. 1 (January 2017): 3–6. https://doi.org/10.2337/dc16-2326.
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    • Luginbuhl, Kelli M., Jeffrey L. Schaal, Bret Umstead, Eric M. Mastria, Xinghai Li, Samagya Banskota, Susan Arnold, Mark Feinglos, David D’Alessio, and Ashutosh Chilkoti. “One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer.” Nat Biomed Eng 1 (2017). https://doi.org/10.1038/s41551-017-0078.
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    • Myers, Martin G. “A Few Words of Introduction From Your New Diabetes Editorial Board.” Diabetes 66, no. 1 (January 2017): 3–4. https://doi.org/10.2337/db16-1301.
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    • Wysham, Carol, Bruno Guerci, David D’Alessio, Nan Jia, and Fady T. Botros. “Baseline factors associated with glycaemic response to treatment with once-weekly dulaglutide in patients with type 2 diabetes.” Diabetes Obes Metab 18, no. 11 (November 2016): 1138–42. https://doi.org/10.1111/dom.12702.
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    • Alzaman, Naweed S., Bess Dawson-Hughes, Jason Nelson, David D’Alessio, and Anastassios G. Pittas. “Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation.” Am J Clin Nutr 104, no. 1 (July 2016): 205–14. https://doi.org/10.3945/ajcn.115.129478.
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    • Cefalu, W. T., A. J. M. Boulton, W. V. Tamborlane, R. G. Moses, D. LeRoith, E. L. Greene, F. B. Hu, et al. “Diabetes care: Lagniappe and seeing is believing!.” Diabetes Care 39, no. 7 (July 1, 2016): 1069–71. https://doi.org/10.2337/dc16-0891.
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    • Salehi, Marzieh, and David A. D’Alessio. “Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.” Surg Obes Relat Dis 12, no. 6 (July 2016): 1230–35. https://doi.org/10.1016/j.soard.2016.05.008.
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    • Shah, Amy S., David D’Alessio, Martha E. Ford-Adams, Ashish P. Desai, and Thomas H. Inge. “Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth.” Diabetes Care 39, no. 6 (June 2016): 934–40. https://doi.org/10.2337/dc16-0067.
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    • Tong, Jenny, Harold W. Davis, Amalia Gastaldelli, and David D’Alessio. “Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1.” J Clin Endocrinol Metab 101, no. 6 (June 2016): 2405–14. https://doi.org/10.1210/jc.2015-4154.
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    • Wolfe, Bruce M., and David A. D’Alessio. “Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care.” Obesity (Silver Spring) 24, no. 6 (June 2016): 1205–6. https://doi.org/10.1002/oby.21531.
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    • Aulinger, Benedikt A., Torsten P. Vahl, Ron L. Prigeon, David A. D’Alessio, and Deborah A. Elder. “The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?” Am J Physiol Endocrinol Metab 310, no. 9 (May 1, 2016): E774–81. https://doi.org/10.1152/ajpendo.00496.2015.
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    • D’Alessio, David. “Is GLP-1 a hormone: Whether and When?” J Diabetes Investig 7 Suppl 1 (April 2016): 50–55. https://doi.org/10.1111/jdi.12466.
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    • Cefalu, William T., Andrew J. M. Boulton, William V. Tamborlane, Robert G. Moses, Derek LeRoith, Eddie L. Greene, Frank B. Hu, et al. “Building Momentum: Taking on the Real “Issues” of Diabetes Care!.” Diabetes Care 39, no. 1 (January 2016): 10–12. https://doi.org/10.2337/dc15-2315.
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    • Gibb, Roger D., Johnson W. McRorie, Darrell A. Russell, Vic Hasselblad, and David A. D’Alessio. “Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus.” Am J Clin Nutr 102, no. 6 (December 2015): 1604–14. https://doi.org/10.3945/ajcn.115.106989.
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    • Inge, Thomas H., Ronald L. Prigeon, Deborah A. Elder, Todd M. Jenkins, Robert M. Cohen, Stavra A. Xanthakos, Stephen C. Benoit, Lawrence M. Dolan, Stephen R. Daniels, and David A. D’Alessio. “Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.” J Pediatr 167, no. 5 (November 2015): 1042-8.e1. https://doi.org/10.1016/j.jpeds.2015.08.020.
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    • Ghosal, Sriparna, Amanda Nunley, Parinaz Mahbod, Alfor G. Lewis, Eric P. Smith, Jenny Tong, David A. D’Alessio, and James P. Herman. “Mouse handling limits the impact of stress on metabolic endpoints.” Physiol Behav 150 (October 15, 2015): 31–37. https://doi.org/10.1016/j.physbeh.2015.06.021.
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    • Salehi, Marzieh, Stephen C. Woods, and David A. D’Alessio. “Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion.” Obesity (Silver Spring) 23, no. 10 (October 2015): 2046–52. https://doi.org/10.1002/oby.21186.
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    • Beamish, Andrew J., David A. D’Alessio, and Thomas H. Inge. “Controversial Issues: When the drugs don't work, can surgery provide a different outcome for diabetic adolescents?” Surg Obes Relat Dis 11, no. 4 (July 2015): 946–48. https://doi.org/10.1016/j.soard.2015.03.006.
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    • Begg, Denovan P., Aaron A. May, Joram D. Mul, Min Liu, David A. D’Alessio, Randy J. Seeley, and Stephen C. Woods. “Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.” Diabetes 64, no. 7 (July 2015): 2457–66. https://doi.org/10.2337/db14-1364.
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    • Koska, Juraj, Michelle Sands, Camelia Burciu, Karen M. D’Souza, Kalyani Raravikar, James Liu, Seth Truran, et al. “Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans.” Diabetes 64, no. 7 (July 2015): 2624–35. https://doi.org/10.2337/db14-0976.
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    • Rosario, Wilfredo, and David D’Alessio. “An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes.” Diabetes 64, no. 7 (July 2015): 2329–31. https://doi.org/10.2337/db15-0436.
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    • Tong, Jenny, and David D’Alessio. “Surgical Treatment of Diabetes: Making a Case for a Pragmatic Approach.” J Clin Endocrinol Metab 100, no. 7 (July 2015): 2536–38. https://doi.org/10.1210/jc.2015-2551.
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    • Ottaway, Nickki, Parinaz Mahbod, Belen Rivero, Lee Ann Norman, Arieh Gertler, David A. D’Alessio, and Diego Perez-Tilve. “Diet-induced obese mice retain endogenous leptin action.” Cell Metab 21, no. 6 (June 2, 2015): 877–82. https://doi.org/10.1016/j.cmet.2015.04.015.
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    • Aulinger, Benedikt A., Torsten P. Vahl, Hilary E. Wilson-Pérez, Ron L. Prigeon, and David A. D’Alessio. “β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity.” J Clin Endocrinol Metab 100, no. 6 (June 2015): 2489–96. https://doi.org/10.1210/jc.2014-4009.
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    • Sandoval, Darleen A., and David A. D’Alessio. “Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.” Physiol Rev 95, no. 2 (April 2015): 513–48. https://doi.org/10.1152/physrev.00013.2014.
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    • Elder, Deborah A., Lindsey N. Hornung, Patricia M. Herbers, Ron Prigeon, Jessica G. Woo, and David A. D’Alessio. “Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes.” J Pediatr 166, no. 3 (March 2015): 672–78. https://doi.org/10.1016/j.jpeds.2014.11.029.
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    • D’Alessio, D., H. -. U. Häring, B. Charbonnel, P. de Pablos-Velasco, C. Candelas, M. -. P. Dain, M. Vincent, V. Pilorget, H. Yki-Järvinen, and H. EAGLE Investigators. “Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes.” Diabetes Obes Metab 17, no. 2 (February 2015): 170–78. https://doi.org/10.1111/dom.12406.
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    • Tong, Jenny, and David D’Alessio. “Ghrelin and hypothalamic development: too little and too much of a good thing.” J Clin Invest 125, no. 2 (February 2015): 490–92. https://doi.org/10.1172/JCI79187.
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    • Vahl, Torsten P., Benedikt A. Aulinger, Eric P. Smith, Deborah L. Drazen, Yve Ulrich-Lai, Randy J. Seeley, Stephen C. Woods, and David A. D’Alessio. “Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia.” Am J Physiol Endocrinol Metab 307, no. 9 (November 1, 2014): E784–92. https://doi.org/10.1152/ajpendo.00339.2014.
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    • Salehi, Marzieh, and David A. D’Alessio. “Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.” Rev Endocr Metab Disord 15, no. 3 (September 2014): 171–79. https://doi.org/10.1007/s11154-014-9291-y.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion.” Diabetologia 57, no. 7 (July 2014): 1495–99. https://doi.org/10.1007/s00125-014-3258-0.
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    • Tong, Jenny, Harold W. Davis, Suzanne Summer, Stephen C. Benoit, Ahrar Haque, Martin Bidlingmaier, Matthias H. Tschöp, and David D’Alessio. “Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.” Diabetes 63, no. 7 (July 2014): 2309–19. https://doi.org/10.2337/db13-1598.
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    • Smith, Eric P., Zhibo An, Constance Wagner, Alfor G. Lewis, Eric B. Cohen, Bailing Li, Parinaz Mahbod, et al. “The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.” Cell Metab 19, no. 6 (June 3, 2014): 1050–57. https://doi.org/10.1016/j.cmet.2014.04.005.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia.” J Clin Endocrinol Metab 99, no. 6 (June 2014): 2008–17. https://doi.org/10.1210/jc.2013-2686.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Beta-Cell Response to Graded up & Down Glucose Infusion after Gastric Bypass Surgery.” Endocrine Reviews 35, no. 3 (June 1, 2014).
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    • Sisley, Stephanie, Ruth Gutierrez-Aguilar, Michael Scott, David A. D’Alessio, Darleen A. Sandoval, and Randy J. Seeley. “Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect.” J Clin Invest 124, no. 6 (June 2014): 2456–63. https://doi.org/10.1172/JCI72434.
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    • Gastaldelli, Amalia, Robert G. Brodows, and David D’Alessio. “The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes.” Clin Endocrinol (Oxf) 80, no. 4 (April 2014): 545–53. https://doi.org/10.1111/cen.12199.
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    • Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.” Gastroenterology 146, no. 3 (March 2014): 669-680.e2. https://doi.org/10.1053/j.gastro.2013.11.044.
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    • Chambers, Adam P., Eric P. Smith, Denovan P. Begg, Bernadette E. Grayson, Stephanie Sisley, Todd Greer, Joyce Sorrell, et al. “Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy.” Am J Physiol Endocrinol Metab 306, no. 4 (February 15, 2014): E424–32. https://doi.org/10.1152/ajpendo.00469.2013.
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    • Gutierrez-Aguilar, Ruth, Dong-Hoon Kim, Marina Casimir, Xiao-Qing Dai, Paul T. Pfluger, Jongsun Park, April Haller, et al. “The role of the transcription factor ETV5 in insulin exocytosis.” Diabetologia 57, no. 2 (February 2014): 383–91. https://doi.org/10.1007/s00125-013-3096-5.
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    • Habegger, Kirk M., Kristy M. Heppner, Sarah E. Amburgy, Nickki Ottaway, Jenna Holland, Christine Raver, Erin Bartley, et al. “GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.” Diabetes 63, no. 2 (February 2014): 505–13. https://doi.org/10.2337/db13-0511.
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    • Tong, Jenny, and David D’Alessio. “Give the receptor a brake: slowing gastric emptying by GLP-1.” Diabetes 63, no. 2 (February 2014): 407–9. https://doi.org/10.2337/db13-1764.
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    • Salehi, M., and D. A. D’Alessio. “Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery.” Reviews in Endocrine and Metabolic Disorders 15, no. 3 (January 1, 2014): 171–79. https://doi.org/10.1007/s11154-014-9291-y.
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    • An, Zhibo, Ronald L. Prigeon, and David A. D’Alessio. “Improved glycemic control enhances the incretin effect in patients with type 2 diabetes.” J Clin Endocrinol Metab 98, no. 12 (December 2013): 4702–8. https://doi.org/10.1210/jc.2013-1199.
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    • Lehti, Maarit, Elizabeth Donelan, William Abplanalp, Omar Al-Massadi, Kirk M. Habegger, Jon Weber, Chandler Ress, et al. “High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.” Circulation 128, no. 22 (November 26, 2013): 2364–71. https://doi.org/10.1161/CIRCULATIONAHA.113.001551.
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    • Schwartz, Michael W., Randy J. Seeley, Matthias H. Tschöp, Stephen C. Woods, Gregory J. Morton, Martin G. Myers, and David D’Alessio. “Cooperation between brain and islet in glucose homeostasis and diabetes.” Nature 503, no. 7474 (November 7, 2013): 59–66. https://doi.org/10.1038/nature12709.
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    • Clemmensen, Christoffer, Sanela Smajilovic, Eric P. Smith, Stephen C. Woods, Hans Bräuner-Osborne, Randy J. Seeley, David A. D’Alessio, and Karen K. Ryan. “Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.” Endocrinology 154, no. 11 (November 2013): 3978–83. https://doi.org/10.1210/en.2013-1529.
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    • Salehi, Marzieh, and David A. D’Alessio. “Going with the flow: adaptation of β-cell function to glucose fluxes after bariatric surgery.” Diabetes 62, no. 11 (November 2013): 3671–73. https://doi.org/10.2337/db13-1213.
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    • Salehi, Marzieh, and David A. D’Alessio. “With the Flow: Adaptation of beta-Cell Function to Glucose Fluxes After Bariatric Surgery.” Diabetes 62, no. 11 (November 2013): 3671–73. https://doi.org/10.2337/db13-1213.
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    • Habegger, Kirk M., Henriette Kirchner, Chun-Xia Yi, Kristy M. Heppner, Dan Sweeney, Nickki Ottaway, Jenna Holland, et al. “GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.” Diabetes 62, no. 9 (September 2013): 3261–67. https://doi.org/10.2337/db13-0117.
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    • Rosenstock, Julio, Helena W. Rodbard, Stephen C. Bain, David D’Alessio, Jochen Seufert, Anne B. Thomsen, Claus Bo Svendsen, J Hans DeVries, and J Hans Liraglutide-Detemir Study Group. “One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target.” J Diabetes Complications 27, no. 5 (September 2013): 492–500. https://doi.org/10.1016/j.jdiacomp.2013.04.008.
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    • Sandoval, D., A. Dunki-Jacobs, J. Sorrell, R. J. Seeley, and D. D. D’Alessio. “Impact of intestinal electrical stimulation on nutrient-induced GLP-1 secretion in vivo.” Neurogastroenterol Motil 25, no. 8 (August 2013): 700–705. https://doi.org/10.1111/nmo.12152.
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    • Koska, Juraj, Kalyani Raravikar, Dawn C. Schwenke, David A. D’Alessio, and Peter D. Reaven. “Direct Effect of Exenatide on Endothelial Function in Humans.” Diabetes 62 (July 1, 2013): A260–A260.
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    • Mahbod, Parinaz, Eric Smith, Connie Wagner, Alfor G. Lewis, Stephen C. Benoit, Joel K. Elmquist, Jeffrey M. Zigman, David A. D’Alessio, and Jenny Tong. “Ghrelin Signaling in the Central Nervous System and/or beta-Cells Is Important for the Regulation of Insulin Secretion and Glucose Tolerance in Mice.” Diabetes 62 (July 1, 2013): A511–A511.
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    • Mul, Joram D., Denovan P. Begg, Jason G. Barrera, Bailing Li, Emily K. Matter, David A. D’Alessio, Stephen C. Woods, Randy J. Seeley, and Darleen A. Sandoval. “High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats.” Am J Physiol Regul Integr Comp Physiol 305, no. 1 (July 1, 2013): R68–77. https://doi.org/10.1152/ajpregu.00588.2012.
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    • Salehi, Marzieh, and David A. D’Alessio. “Neurally Induced Postprandial Insulin Secretion Is Enhanced Similarly in Patients With and Without Hypoglycemia after Gastric Bypass Surgery.” Diabetes 62 (July 1, 2013): A39–A39.
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    • Tong, Jenny, Nimita Dave, Ganesh M. Mugundu, Harold W. Davis, Bruce D. Gaylinn, Michael O. Thorner, Matthias H. Tschöp, David D’Alessio, and Pankaj B. Desai. “The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.” Eur J Endocrinol 168, no. 6 (June 2013): 821–28. https://doi.org/10.1530/EJE-13-0072.
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    • Tong, Jenny, Ronald L. Prigeon, Harold W. Davis, Martin Bidlingmaier, Matthias H. Tschöp, and David D’Alessio. “Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans.” J Clin Endocrinol Metab 98, no. 6 (June 2013): 2536–43. https://doi.org/10.1210/jc.2012-4162.
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    • Habegger, Kirk M., Kerstin Stemmer, Christine Cheng, Timo D. Müller, Kristy M. Heppner, Nickki Ottaway, Jenna Holland, et al. “Fibroblast growth factor 21 mediates specific glucagon actions.” Diabetes 62, no. 5 (May 2013): 1453–63. https://doi.org/10.2337/db12-1116.
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    • Begg, Denovan P., Joram D. Mul, Min Liu, Brianne M. Reedy, David A. D’Alessio, Randy J. Seeley, and Stephen C. Woods. “Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.” Endocrinology 154, no. 3 (March 2013): 1047–54. https://doi.org/10.1210/en.2012-1929.
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    • Cummings, Bethany P., Andrew A. Bremer, Timothy J. Kieffer, David D’Alessio, and Peter J. Havel. “Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques.” J Endocrinol 216, no. 2 (February 2013): 207–15. https://doi.org/10.1530/JOE-12-0459.
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    • Jessen, Lene, Benedikt A. Aulinger, Jonathan L. Hassel, Kyle J. Roy, Eric P. Smith, Todd M. Greer, Stephen C. Woods, Randy J. Seeley, and David A. D’Alessio. “Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4.” Endocrinology 153, no. 12 (December 2012): 5735–45. https://doi.org/10.1210/en.2012-1358.
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    • Salehi, Marzieh, Benedict Aulinger, and David A. D’Alessio. “Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test.” Diabetes 61, no. 11 (November 2012): 2728–33. https://doi.org/10.2337/db11-1825.
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    • Chambers, Adam P., Hilary E. Wilson-Perez, Sean McGrath, Bernadette E. Grayson, Karen K. Ryan, David A. D’Alessio, Stephen C. Woods, Darleen A. Sandoval, and Randy J. Seeley. “Effect of vertical sleeve gastrectomy on food selection and satiation in rats.” Am J Physiol Endocrinol Metab 303, no. 8 (October 15, 2012): E1076–84. https://doi.org/10.1152/ajpendo.00211.2012.
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    • Tong, Jenny, David D’Alessio, Juliane Ramisch, Harold W. Davis, Elizabeth Stambrook, Matthias H. Tschöp, and Martin Bidlingmaier. “Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.” J Clin Endocrinol Metab 97, no. 9 (September 2012): 3366–74. https://doi.org/10.1210/jc.2012-2012.
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    • Kirk, Shelley, Bonnie Brehm, Brian E. Saelens, Jessica G. Woo, Elizabeth Kissel, David D’Alessio, Christopher Bolling, and Stephen R. Daniels. “Role of carbohydrate modification in weight management among obese children: a randomized clinical trial.” J Pediatr 161, no. 2 (August 2012): 320-7.e1. https://doi.org/10.1016/j.jpeds.2012.01.041.
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    • Liu, Min, Ling Shen, Denovan P. Begg, David A. D’alessio, and Stephen C. Woods. “Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats.” J Neurosci Methods 209, no. 1 (July 30, 2012): 106–12. https://doi.org/10.1016/j.jneumeth.2012.05.034.
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    • DeVries, J Hans, Stephen C. Bain, Helena W. Rodbard, Jochen Seufert, David D’Alessio, Anne B. Thomsen, Marcin Zychma, Julio Rosenstock, and Julio Liraglutide-Detemir Study Group. “Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.” Diabetes Care 35, no. 7 (July 2012): 1446–54. https://doi.org/10.2337/dc11-1928.
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    • Mul, Joram D., Denovan P. Begg, Suzanne I. M. Alsters, Gijs van Haaften, Karen J. Duran, David A. D’Alessio, Carel W. le Roux, et al. “Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.” Am J Physiol Endocrinol Metab 303, no. 1 (July 1, 2012): E103–10. https://doi.org/10.1152/ajpendo.00159.2012.
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    • Elder, Deborah A., Patricia M. Herbers, Tammy Weis, Debra Standiford, Jessica G. Woo, and David A. D’Alessio. “β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus.” J Pediatr 160, no. 6 (June 2012): 904–10. https://doi.org/10.1016/j.jpeds.2011.12.002.
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    • Lu, Wendell J., Qing Yang, Li Yang, Dana Lee, David D’Alessio, and Patrick Tso. “Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP.” Lipids 47, no. 6 (June 2012): 571–80. https://doi.org/10.1007/s11745-011-3650-1.
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    • Rebholz, Sandra L., Thomas Jones, Katie T. Burke, Anja Jaeschke, Patrick Tso, David A. D’Alessio, and Laura A. Woollett. “Multiparity leads to obesity and inflammation in mothers and obesity in male offspring.” Am J Physiol Endocrinol Metab 302, no. 4 (February 15, 2012): E449–57. https://doi.org/10.1152/ajpendo.00487.2011.
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    • Sandoval, Darleen, Jason G. Barrera, Margaret A. Stefater, Stephanie Sisley, Stephen C. Woods, David D. D’Alessio, and Randy J. Seeley. “The anorectic effect of GLP-1 in rats is nutrient dependent.” Plos One 7, no. 12 (2012): e51870. https://doi.org/10.1371/journal.pone.0051870.
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    • Chambers, Adam P., Margaret A. Stefater, Hilary E. Wilson-Perez, Lene Jessen, Stephanie Sisley, Karen K. Ryan, Shrawan Gaitonde, et al. “Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats.” Physiol Behav 105, no. 1 (November 30, 2011): 120–23. https://doi.org/10.1016/j.physbeh.2011.05.026.
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    • Summer, Suzanne S., Bonnie J. Brehm, Stephen C. Benoit, and David A. D’Alessio. “Adiponectin changes in relation to the macronutrient composition of a weight-loss diet.” Obesity (Silver Spring) 19, no. 11 (November 2011): 2198–2204. https://doi.org/10.1038/oby.2011.60.
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    • Carrel, Guillaume, Léonie Egli, Christel Tran, Philippe Schneiter, Vittorio Giusti, David D’Alessio, and Luc Tappy. “Contributions of fat and protein to the incretin effect of a mixed meal.” Am J Clin Nutr 94, no. 4 (October 2011): 997–1003. https://doi.org/10.3945/ajcn.111.017574.
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    • D’Alessio, D. “The role of dysregulated glucagon secretion in type 2 diabetes.” Diabetes Obes Metab 13 Suppl 1 (October 2011): 126–32. https://doi.org/10.1111/j.1463-1326.2011.01449.x.
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    • Chambers, Adam P., Lene Jessen, Karen K. Ryan, Stephanie Sisley, Hilary E. Wilson-Pérez, Margaret A. Stefater, Shrawan G. Gaitonde, et al. “Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats.” Gastroenterology 141, no. 3 (September 2011): 950–58. https://doi.org/10.1053/j.gastro.2011.05.050.
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    • Salehi, Marzieh, Ronald L. Prigeon, and David A. D’Alessio. “Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans.” Diabetes 60, no. 9 (September 2011): 2308–14. https://doi.org/10.2337/db11-0203.
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    • D’Alessio, David A. “What if gut hormones aren't really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract.” Endocrinology 152, no. 8 (August 2011): 2925–26. https://doi.org/10.1210/en.2011-1385.
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    • Lo, Chun-Min, Silvana Obici, H Henry Dong, Michael Haas, Dawnwen Lou, Dae Hyun Kim, Min Liu, David D’Alessio, Stephen C. Woods, and Patrick Tso. “Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.” Diabetes 60, no. 7 (July 2011): 2000–2007. https://doi.org/10.2337/db10-0789.
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    • Barrera, Jason G., Darleen A. Sandoval, David A. D’Alessio, and Randy J. Seeley. “GLP-1 and energy balance: an integrated model of short-term and long-term control.” Nat Rev Endocrinol 7, no. 9 (June 7, 2011): 507–16. https://doi.org/10.1038/nrendo.2011.77.
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    • Brehm, Bonnie J., Donna M. Gates, Mary Singler, Paul A. Succop, and David A. D’Alessio. “Environmental changes to control obesity: a randomized controlled trial in manufacturing companies.” Am J Health Promot 25, no. 5 (May 2011): 334–40. https://doi.org/10.4278/ajhp.090128-QUAN-37.
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    • Clegg, Deborah J., Koro Gotoh, Christopher Kemp, Matthew D. Wortman, Stephen C. Benoit, Lynda M. Brown, David D’Alessio, Patrick Tso, Randy J. Seeley, and Stephen C. Woods. “Consumption of a high-fat diet induces central insulin resistance independent of adiposity.” Physiol Behav 103, no. 1 (April 18, 2011): 10–16. https://doi.org/10.1016/j.physbeh.2011.01.010.
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    • Tong, Jenny, Erica Mannea, Pascaline Aimé, Paul T. Pfluger, Chun-Xia Yi, Tamara R. Castaneda, Harold W. Davis, et al. “Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans.” J Neurosci 31, no. 15 (April 13, 2011): 5841–46. https://doi.org/10.1523/JNEUROSCI.5680-10.2011.
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    • Barrera, Jason G., Kenneth R. Jones, James P. Herman, David A. D’Alessio, Stephen C. Woods, and Randy J. Seeley. “Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function.” J Neurosci 31, no. 10 (March 9, 2011): 3904–13. https://doi.org/10.1523/JNEUROSCI.2212-10.2011.
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    • Kindel, Tammy L., Paulo J. F. Martins, Stephanie M. Yoder, Ronald J. Jandacek, Randy J. Seeley, David A. D’Alessio, Silvana Obici, and Patrick Tso. “Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents.” Obesity (Silver Spring) 19, no. 2 (February 2011): 380–87. https://doi.org/10.1038/oby.2010.263.
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    • Klimek, A. M., G. Soukhatcheva, D. M. Thompson, G. L. Warnock, M. Salehi, H. Rilo, D. DAlessio, G. S. Meneilly, C. Panagiotopoulos, and C. B. Verchere. “Erratum: Impaired proinsulin processing is a characteristic of transplanted islets (American Journal of Transplantation (2009) 9 (2119-2125) (doi: 10.1111/j.1600-6143.2009.02740.x)).” American Journal of Transplantation 11, no. 2 (February 1, 2011): 414. https://doi.org/10.1111/j.1600-6143.2010.03435.x.
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    • Tong, Jenny, and David D’Alessio. “Eating disorders and gastrointestinal peptides.” Curr Opin Endocrinol Diabetes Obes 18, no. 1 (February 2011): 42–49. https://doi.org/10.1097/MED.0b013e328341e12b.
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    • Zhang, Rong, Ryan Jankord, Jonathan N. Flak, Matia B. Solomon, David A. D’Alessio, and James P. Herman. “Role of glucocorticoids in tuning hindbrain stress integration.” J Neurosci 30, no. 44 (November 3, 2010): 14907–14. https://doi.org/10.1523/JNEUROSCI.0522-10.2010.
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    • Kohli, Rohit, Michelle Kirby, Kenneth D. R. Setchell, Pinky Jha, Kori Klustaitis, Laura A. Woollett, Paul T. Pfluger, et al. “Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities.” Am J Physiol Gastrointest Liver Physiol 299, no. 3 (September 2010): G652–60. https://doi.org/10.1152/ajpgi.00221.2010.
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    • Tong, Jenny, Ronald L. Prigeon, Harold W. Davis, Martin Bidlingmaier, Steven E. Kahn, David E. Cummings, Matthias H. Tschöp, and David D’Alessio. “Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.” Diabetes 59, no. 9 (September 2010): 2145–51. https://doi.org/10.2337/db10-0504.
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    • Elder, Deborah A., Jessica G. Woo, and David A. D’Alessio. “Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes.” Pediatr Diabetes 11, no. 5 (August 2010): 314–21. https://doi.org/10.1111/j.1399-5448.2009.00601.x.
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    • Abumrad, N., M. M. Meguid, S. Klein, C. Pichard, D. D’Alessio, and L. Tappy. “Editorial introductions.” Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (July 1, 2010). https://doi.org/10.1097/MCO.0b013e32833b0e8c.
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    • D’Alessio, David A. “Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target?” Diabetes 59, no. 7 (July 2010): 1572–74. https://doi.org/10.2337/db10-0299.
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    • Lê, Kim-Anne, David A. D’Alessio, and Luc Tappy. “Metabolic effects of excess energy intake: does food composition matter?” Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (July 2010): 429–31. https://doi.org/10.1097/mco.0b013e32833a76a8.
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    • Diab, Dima L., and David A. D’Alessio. “The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.” Curr Diab Rep 10, no. 3 (June 2010): 192–98. https://doi.org/10.1007/s11892-010-0114-6.
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    • Kindel, Tammy L., Stephanie M. Yoder, David A. D’Alessio, and Patrick Tso. “The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.” Obes Surg 20, no. 6 (June 2010): 768–75. https://doi.org/10.1007/s11695-010-0095-1.
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    • Salehi, Marzieh, Benedict Aulinger, Ronald L. Prigeon, and David A. D’Alessio. “Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes.” Diabetes 59, no. 6 (June 2010): 1330–37. https://doi.org/10.2337/db09-1253.
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    • Pérez-Tilve, Diego, Lucas González-Matías, Benedikt A. Aulinger, Mayte Alvarez-Crespo, Manuel Gil-Lozano, Elias Alvarez, Amalia M. Andrade-Olivie, Matthias H. Tschöp, David A. D’Alessio, and Federico Mallo. “Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system.” Am J Physiol Endocrinol Metab 298, no. 5 (May 2010): E1088–96. https://doi.org/10.1152/ajpendo.00464.2009.
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    • Tong, Jenny, Matthias H. Tschöp, Benedikt A. Aulinger, Harold W. Davis, Qing Yang, Jianhua Liu, Bruce D. Gaylinn, Michael O. Thorner, David D’Alessio, and Patrick Tso. “The intestinal lymph fistula model--a novel approach to study ghrelin secretion.” Am J Physiol Gastrointest Liver Physiol 298, no. 3 (March 2010): G474–80. https://doi.org/10.1152/ajpgi.00367.2009.
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    • Vahl, Torsten P., Deborah L. Drazen, Randy J. Seeley, David A. D’Alessio, and Stephen C. Woods. “Meal-anticipatory glucagon-like peptide-1 secretion in rats.” Endocrinology 151, no. 2 (February 2010): 569–75. https://doi.org/10.1210/en.2009-1002.
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    • Barrera, Jason G., David A. D’Alessio, Daniel J. Drucker, Stephen C. Woods, and Randy J. Seeley. “Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats.” Diabetes 58, no. 12 (December 2009): 2820–27. https://doi.org/10.2337/db09-0281.
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    • Falciglia, Mercedes, Ron W. Freyberg, Peter L. Almenoff, David A. D’Alessio, and Marta L. Render. “Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis.” Crit Care Med 37, no. 12 (December 2009): 3001–9. https://doi.org/10.1097/CCM.0b013e3181b083f7.
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    • Jessen, Lene, and David D’Alessio. “The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.” Gastroenterology 137, no. 6 (December 2009): 1891–94. https://doi.org/10.1053/j.gastro.2009.10.013.
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    • Kindel, Tammy L., Stephanie M. Yoder, Randy J. Seeley, David A. D’Alessio, and Patrick Tso. “Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism.” J Gastrointest Surg 13, no. 10 (October 2009): 1762–72. https://doi.org/10.1007/s11605-009-0912-9.
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    • Urbina, E. M., P. Khoury, L. J. Martin, D. D’Alessio, and L. M. Dolan. “Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults.” Int J Obes (Lond) 33, no. 10 (October 2009): 1118–25. https://doi.org/10.1038/ijo.2009.164.
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    • Klimek, A. M., G. Soukhatcheva, D. M. Thompson, G. L. Warnock, M. Salehi, H. Rilo, D. D’Alessio, G. S. Meneilly, C. Panagiotopoulos, and C. B. Verchere. “Impaired proinsulin processing is a characteristic of transplanted islets.” Am J Transplant 9, no. 9 (September 2009): 2119–25. https://doi.org/10.1111/j.1600-6143.2009.02740.x.
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    • Zhang, R., B. A. Packard, M. Tauchi, D. A. D’Alessio, and J. P. Herman. “Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 14, (5913-5918) 10.1073/pnas.0808716106).” Proceedings of the National Academy of Sciences of the United States of America 106, no. 32 (August 11, 2009): 13636. https://doi.org/10.1073/pnas.0907839106.
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    • Cota, Daniela, Darleen A. Sandoval, Massimiliano Olivieri, Elena Prodi, David A. D’Alessio, Stephen C. Woods, Randy J. Seeley, and Silvana Obici. “Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.” Obesity (Silver Spring) 17, no. 8 (August 2009): 1641–45. https://doi.org/10.1038/oby.2009.84.
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    • Abumrad, N., R. F. Grimble, C. Pichard, M. M. Meguid, D. D’Alessio, and L. Tappy. “Editorial introductions.” Current Opinion in Clinical Nutrition and Metabolic Care 12, no. 4 (July 1, 2009). https://doi.org/10.1097/MCO.0b013e32832d3ed6.
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    • Kim, Dong-Hoon, David A. D’Alessio, Stephen C. Woods, and Randy J. Seeley. “The effects of GLP-1 infusion in the hepatic portal region on food intake.” Regul Pept 155, no. 1–3 (June 5, 2009): 110–14. https://doi.org/10.1016/j.regpep.2009.03.002.
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    • Elder, Deborah A., and David A. D’Alessio. “beta-Cell Function in Adolescents Presenting with Type 2 Diabetes Is Impaired and Comparable to Newly Diagnosed Diabetic Adults.” Diabetes 58 (June 1, 2009): A463–A463.
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    • Jessen, Lene, Benedikt A. Aulinger, Todd Greer, Randy J. Seeley, Stephen C. Woods, and David A. D’Alessio. “Effects of Glucagon-Like Peptide-1 and Exendin-4 on Food Intake with and without DPP-4 Inhibition.” Diabetes 58 (June 1, 2009): A395–A395.
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    • Perez-Tilve, Diego, Lucas Gonzalez-Matias, Benedikt A. Aulinger, Mayte Alvarez-Crespo, Manuel Gil-Lozano, Matthias H. Tschoep, David A. D’Alessio, and Federico Mallo. “Exendin-4 Increases Blood Glucose Levels Acutely in Rats by Activation of the Sympathetic Nervous System.” Diabetes 58 (June 1, 2009): A135–36.
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    • Salehi, Marzieh, J Wesley Alexander, David R. Fischer, Jenny Tong, and David A. D’Alessio. “Insulin Secretion Mediated by GLP-1 Action Is Enhanced Following Roux-en-Y Gastric Bypass Surgery.” Diabetes 58 (June 1, 2009): A39–40.
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    • Zhang, Rong, Benjamin A. Packard, Miyuki Tauchi, David A. D’Alessio, and James P. Herman. “Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress.” Proc Natl Acad Sci U S A 106, no. 14 (April 7, 2009): 5913–18. https://doi.org/10.1073/pnas.0808716106.
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    • Brehm, Bonnie J., Barbara L. Lattin, Suzanne S. Summer, Jane A. Boback, Gina M. Gilchrist, Ronald J. Jandacek, and David A. D’Alessio. “One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes.” Diabetes Care 32, no. 2 (February 2009): 215–20. https://doi.org/10.2337/dc08-0687.
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    • Shertzer, Howard G., Scott N. Schneider, Eric L. Kendig, Deborah J. Clegg, David A. D’Alessio, Elisabet Johansson, and Mary Beth Genter. “Tetrahydroindenoindole inhibits the progression of diabetes in mice.” Chem Biol Interact 177, no. 1 (January 15, 2009): 71–80. https://doi.org/10.1016/j.cbi.2008.09.001.
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    • D’Alessio, David A., Amanda M. Denney, Linda M. Hermiller, Ronald L. Prigeon, Julie M. Martin, William G. Tharp, Monica Liqueros Saylan, et al. “Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes.” J Clin Endocrinol Metab 94, no. 1 (January 2009): 81–88. https://doi.org/10.1210/jc.2008-1135.
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    • Salehi, Marzieh, Torsten P. Vahl, and David A. D’Alessio. “Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion.” J Clin Endocrinol Metab 93, no. 12 (December 2008): 4909–16. https://doi.org/10.1210/jc.2008-0605.
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    • Tauchi, Miyuki, Rong Zhang, David A. D’Alessio, Javier E. Stern, and James P. Herman. “Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.” J Chem Neuroanat 36, no. 3–4 (December 2008): 144–49. https://doi.org/10.1016/j.jchemneu.2008.07.009.
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    • Woods, Stephen C., and David A. D’Alessio. “Central control of body weight and appetite.” J Clin Endocrinol Metab 93, no. 11 Suppl 1 (November 2008): S37–50. https://doi.org/10.1210/jc.2008-1630.
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    • Brehm, Bonnie J., and David A. D’Alessio. “Benefits of high-protein weight loss diets: enough evidence for practice?” Curr Opin Endocrinol Diabetes Obes 15, no. 5 (October 2008): 416–21. https://doi.org/10.1097/MED.0b013e328308dc13.
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    • Perez-Tilve, Diego, David A. D’Alessio, and Matthias H. Tschöp. “A sweet spot for the bariatric surgeon.” Cell Metabolism 8, no. 3 (September 2008): 177–79. https://doi.org/10.1016/j.cmet.2008.08.012.
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    • D’Alessio, David A. “Citation for the 2008 Ernst Oppenheimer Award of The Endocrine Society to Dr. Randy J. Seeley.” Endocrine Reviews 29, no. 5 (August 1, 2008): 636–37.
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    • D’Alessio, David A. “Randy J Seeley.” Journal of Clinical Endocrinology & Metabolism 93, no. 8 (August 1, 2008): 3235–36.
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    • D’Alessio, David A. “Dr. Randy J. Seeley.” Endocrinology 149, no. 8 (August 1, 2008): 4234–35.
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    • Elder, Deborah A., David A. D’Alessio, Ori Eyal, Robin Mueller, Franklin O. Smith, Alvina R. Kansra, and Susan R. Rose. “Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion.” Pediatr Blood Cancer 51, no. 2 (August 2008): 256–60. https://doi.org/10.1002/pbc.21589.
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    • Sandoval, Darleen A., Didier Bagnol, Stephen C. Woods, David A. D’Alessio, and Randy J. Seeley. “Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake.” Diabetes 57, no. 8 (August 2008): 2046–54. https://doi.org/10.2337/db07-1824.
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    • Strawn, J. R., D. A. D’Alessio, P. E. Keck, and R. J. Seeley. “Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder.” Journal of Psychiatric Research 42, no. 9 (July 2008): 787–89. https://doi.org/10.1016/j.jpsychires.2007.08.007.
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    • Lu, Wendell J., Qing Yang, William Sun, Stephen C. Woods, David D’Alessio, and Patrick Tso. “Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose.” Am J Physiol Gastrointest Liver Physiol 294, no. 5 (May 2008): G1130–38. https://doi.org/10.1152/ajpgi.00400.2007.
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    • Salehi, Marzieh, Benedikt A. Aulinger, and David A. D’Alessio. “Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins.” Endocrine Reviews 29, no. 3 (May 2008): 367–79. https://doi.org/10.1210/er.2007-0031.
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    • Gray, Dona L., Kevin D. O’Brien, David A. D’Alessio, Bonnie J. Brehm, and Mark A. Deeg. “Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women.” Metabolism 57, no. 4 (April 2008): 473–78. https://doi.org/10.1016/j.metabol.2007.11.007.
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    • Reed, Jacquelyn A., Stephen C. Benoit, Paul T. Pfluger, Matthias H. Tschöp, David A. D’Alessio, and Randy J. Seeley. “Mice with chronically increased circulating ghrelin develop age-related glucose intolerance.” Am J Physiol Endocrinol Metab 294, no. 4 (April 2008): E752–60. https://doi.org/10.1152/ajpendo.00463.2007.
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    • Tauchi, Miyuki, Rong Zhang, David A. D’Alessio, Randy J. Seeley, and James P. Herman. “Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress.” Exp Neurol 210, no. 2 (April 2008): 458–66. https://doi.org/10.1016/j.expneurol.2007.11.016.
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    • Kemp, Christopher J., David A. D’Alessio, Robert O. Scott, Gary R. Kelm, Stephen T. Meller, Jason G. Barrera, Randy J. Seeley, Deborah J. Clegg, and Stephen C. Benoit. “Voluntary consumption of ethyl oleate reduces food intake and body weight in rats.” Physiol Behav 93, no. 4–5 (March 18, 2008): 912–18. https://doi.org/10.1016/j.physbeh.2007.12.008.
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    • Brehm, Bonnie J., and David A. D’Alessio. “Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff.” Nature Clinical Practice. Endocrinology & Metabolism 4, no. 3 (March 2008): 140–46. https://doi.org/10.1038/ncpendmet0730.
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    • Shertzer, Howard G., Scott N. Schneider, Eric L. Kendig, Deborah J. Clegg, David A. D’Alessio, and Mary Beth Genter. “Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.” Biochemical Pharmacology 75, no. 6 (March 2008): 1402–10. https://doi.org/10.1016/j.bcp.2007.12.003.
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    • Rodieux, Frédérique, Vittorio Giusti, David A. D’Alessio, Michel Suter, and Luc Tappy. “Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.” Obesity (Silver Spring) 16, no. 2 (February 2008): 298–305. https://doi.org/10.1038/oby.2007.83.
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    • Guerdjikova, Anna I., Susan L. McElroy, Renu Kotwal, Jeffrey A. Welge, Erik Nelson, Katie Lake, David D’ Alessio, Paul E. Keck, and James I. Hudson. “High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial.” Hum Psychopharmacol 23, no. 1 (January 2008): 1–11. https://doi.org/10.1002/hup.899.
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    • D’Alessio, David, Wendell Lu, William Sun, Shuqin Zheng, Qing Yang, Randy Seeley, Stephen C. Woods, and Patrick Tso. “Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system.” Am J Physiol Regul Integr Comp Physiol 293, no. 6 (December 2007): R2163–69. https://doi.org/10.1152/ajpregu.00911.2006.
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    • Elder, Deborah A., Jamie L. Wooldridge, Lawrence M. Dolan, and David A. D’Alessio. “Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes.” J Pediatr 151, no. 6 (December 2007): 653–58. https://doi.org/10.1016/j.jpeds.2007.05.012.
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    • Lu, Wendell J., Qing Yang, William Sun, Stephen C. Woods, David D’Alessio, and Patrick Tso. “The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate.” Am J Physiol Gastrointest Liver Physiol 293, no. 5 (November 2007): G963–71. https://doi.org/10.1152/ajpgi.00146.2007.
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    • Brehm, Bonnie, Donna Gates, Mary Singler, Amanda Poeppelman, Paul Succop, and David D’Alessio. “Prevalence of obesity and cardiovascular risk factors among manufacturing company employees in Kentucky.” Aaohn J 55, no. 10 (October 2007): 397–406. https://doi.org/10.1177/216507990705501002.
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    • Vahl, Torsten P., Miyuki Tauchi, Timothy S. Durler, Eileen E. Elfers, Timothy M. Fernandes, Ronald D. Bitner, Kay S. Ellis, et al. “Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats.” Endocrinology 148, no. 10 (October 2007): 4965–73. https://doi.org/10.1210/en.2006-0153.
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    • Wiedmer, Petra, Rubén Nogueiras, Fabio Broglio, David D’Alessio, and Matthias H. Tschöp. “Ghrelin, obesity and diabetes.” Nat Clin Pract Endocrinol Metab 3, no. 10 (October 2007): 705–12. https://doi.org/10.1038/ncpendmet0625.
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    • Abumrad, N., A. Doria, C. Pichard, M. Meguid, D. D’Alessio, and L. Tappy. “Editorial introductions.” Current Opinion in Clinical Nutrition and Metabolic Care 10, no. 4 (July 1, 2007). https://doi.org/10.1097/01.mco.0000278187.72147.37.
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    • Lê, Kim-Anne, Luc Tappy, and David A. D’Alessio. “Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?” Current Opinion in Clinical Nutrition and Metabolic Care 10, no. 4 (July 2007): 494–97. https://doi.org/10.1097/mco.0b013e3281e72abf.
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    • Urbina, E. M., J. A. Bean, S. R. Daniels, D. D’Alessio, and L. M. Dolan. “Overweight and hyperinsulinemia provide individual contributions to compromises in brachial artery distensibility in healthy adolescents and young adults.” Journal of the American Society of Hypertension 1, no. 3 (May 1, 2007): 200–207. https://doi.org/10.1016/j.jash.2007.01.008.
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    • Aulinger, Benedikt, and David D’Alessio. “Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic.” Curr Opin Endocrinol Diabetes Obes 14, no. 1 (February 2007): 68–73. https://doi.org/10.1097/MED.0b013e328013e79e.
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    • Pfluger, P. T., J. Kampe, T. R. Castaneda, T. Vahl, D. A. D’Alessio, T. Kruthaupt, S. C. Benoit, et al. “Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.” J Clin Endocrinol Metab 92, no. 2 (February 2007): 583–88. https://doi.org/10.1210/jc.2006-1425.
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    • McElroy, Susan L., Renu Kotwal, Anna I. Guerdjikova, Jeffrey A. Welge, Erik B. Nelson, Kathleen A. Lake, David A. D’Alessio, Paul E. Keck, and James I. Hudson. “Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial.” J Clin Psychiatry 67, no. 12 (December 2006): 1897–1906. https://doi.org/10.4088/jcp.v67n1209.
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    • Watts, Nelson B., and David A. D’Alessio. “Type 2 diabetes, thiazolidinediones: bad to the bone?” J Clin Endocrinol Metab 91, no. 9 (September 2006): 3276–78. https://doi.org/10.1210/jc.2006-1235.
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    • Abumrad, N., A. Lange, C. Pichard, M. Meguid, D. D’Alessio, and L. Tappy. “Editorial introductions.” Current Opinion in Clinical Nutrition and Metabolic Care 9, no. 4 (July 1, 2006). https://doi.org/10.1097/01.mco.0000232890.36297.10.
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    • Tappy, Luc, and David D’Alessio. “Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?” Curr Opin Clin Nutr Metab Care 9, no. 4 (July 2006): 455–57. https://doi.org/10.1097/01.mco.0000232907.76859.1c.
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    • Um, Sung Hee, David D’Alessio, and George Thomas. “Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.” Cell Metab 3, no. 6 (June 2006): 393–402. https://doi.org/10.1016/j.cmet.2006.05.003.
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    • Salehi, Marzieh, and David A. D’Alessio. “New therapies for type 2 diabetes based on glucagon-like peptide 1.” Cleve Clin J Med 73, no. 4 (April 2006): 382–89. https://doi.org/10.3949/ccjm.73.4.382.
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    • Drazen, Deborah L., Torsten P. Vahl, David A. D’Alessio, Randy J. Seeley, and Stephen C. Woods. “Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status.” Endocrinology 147, no. 1 (January 2006): 23–30. https://doi.org/10.1210/en.2005-0973.
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    • Elder, Deborah A., Ronald L. Prigeon, R Paul Wadwa, Lawrence M. Dolan, and David A. D’Alessio. “Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults.” J Clin Endocrinol Metab 91, no. 1 (January 2006): 185–91. https://doi.org/10.1210/jc.2005-0853.
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    • Gotoh, Koro, Min Liu, Stephen C. Benoit, Deborah J. Clegg, W Sean Davidson, David D’Alessio, Randy J. Seeley, Patrick Tso, and Stephen C. Woods. “Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.” Am J Physiol Regul Integr Comp Physiol 290, no. 1 (January 2006): R202–7. https://doi.org/10.1152/ajpregu.00502.2005.
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    • D’Alessio, David A., Darleen A. Sandoval, and Randy J. Seeley. “New ways in which GLP-1 can regulate glucose homeostasis.” J Clin Invest 115, no. 12 (December 2005): 3406–8. https://doi.org/10.1172/JCI27207.
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    • Ahmad, Syed A., Andrew M. Lowy, Curtis J. Wray, David D’Alessio, Kywran A. Choe, Laura E. James, Andreas Gelrud, Jeffrey B. Matthews, and Horacio L. R. Rilo. “Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis.” J Am Coll Surg 201, no. 5 (November 2005): 680–87. https://doi.org/10.1016/j.jamcollsurg.2005.06.268.
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    • Vahl, Torsten P., Yvonne M. Ulrich-Lai, Michelle M. Ostrander, C Mark Dolgas, Eileen E. Elfers, Randy J. Seeley, David A. D’Alessio, and James P. Herman. “Comparative analysis of ACTH and corticosterone sampling methods in rats.” Am J Physiol Endocrinol Metab 289, no. 5 (November 2005): E823–28. https://doi.org/10.1152/ajpendo.00122.2005.
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    • D’Alessio, David A., and Torsten P. Vahl. “Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches.” Curr Diab Rep 5, no. 5 (October 2005): 346–52. https://doi.org/10.1007/s11892-005-0092-2.
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    • Proulx, Karine, Daniela Cota, Tamara R. Castañeda, Matthias H. Tschöp, David A. D’Alessio, Patrick Tso, Stephen C. Woods, and Randy J. Seeley. “Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.” Am J Physiol Regul Integr Comp Physiol 289, no. 3 (September 2005): R729–37. https://doi.org/10.1152/ajpregu.00029.2005.
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    • D’Alessio, David A., Kim-Anne Lê, and Luc Tappy. “Type 2 diabetes and insulin resistance: an hepatocentric phenomenon?” Curr Opin Clin Nutr Metab Care 8, no. 4 (July 2005): 428–30. https://doi.org/10.1097/01.mco.0000172584.32632.b0.
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    • Dolan, Lawrence M., Judy Bean, David D’Alessio, Robert M. Cohen, John A. Morrison, Elizabeth Goodman, and Stephen R. Daniels. “Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents.” J Pediatr 146, no. 6 (June 2005): 751–58. https://doi.org/10.1016/j.jpeds.2005.01.045.
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    • Qin, Xiaofa, Hui Shen, Min Liu, Qing Yang, Shuqin Zheng, Mary Sabo, David A. D’Alessio, and Patrick Tso. “GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.” Am J Physiol Gastrointest Liver Physiol 288, no. 5 (May 2005): G943–49. https://doi.org/10.1152/ajpgi.00303.2004.
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    • O’Brien, Kevin D., Bonnie J. Brehm, Randy J. Seeley, Judy Bean, Mark H. Wener, Stephen Daniels, and David A. D’Alessio. “Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.” J Clin Endocrinol Metab 90, no. 4 (April 2005): 2244–49. https://doi.org/10.1210/jc.2004-1011.
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    • Brehm, Bonnie J., Suzanne E. Spang, Barbara L. Lattin, Randy J. Seeley, Stephen R. Daniels, and David A. D’Alessio. “The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets.” J Clin Endocrinol Metab 90, no. 3 (March 2005): 1475–82. https://doi.org/10.1210/jc.2004-1540.
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    • Strader, April D., Torsten P. Vahl, Ronald J. Jandacek, Stephen C. Woods, David A. D’Alessio, and Randy J. Seeley. “Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats.” Am J Physiol Endocrinol Metab 288, no. 2 (February 2005): E447–53. https://doi.org/10.1152/ajpendo.00153.2004.
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    • Lachey, Jennifer L., David A. D’Alessio, Linda Rinaman, Joel K. Elmquist, Daniel J. Drucker, and Randy J. Seeley. “The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.” Endocrinology 146, no. 1 (January 2005): 458–62. https://doi.org/10.1210/en.2004-0419.
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    • Wray, Curtis J., Syed A. Ahmad, Andrew M. Lowy, David A. D’Alessio, Andreas Gelrud, Kyuran A. Choe, Debbie A. Soldano, Jeffrey B. Matthews, and Horacio L. Rodriguez-Rilo. “Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions.” Pancreatology 5, no. 6 (2005): 562–69. https://doi.org/10.1159/000087498.
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    • Woods, Stephen C., David A. D’Alessio, Patrick Tso, Paul A. Rushing, Deborah J. Clegg, Stephen C. Benoit, Koro Gotoh, Min Liu, and Randy J. Seeley. “Consumption of a high-fat diet alters the homeostatic regulation of energy balance.” Physiol Behav 83, no. 4 (December 30, 2004): 573–78. https://doi.org/10.1016/j.physbeh.2004.07.026.
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    • D’Alessio, D., T. Vahl, and R. Prigeon. “Effects of glucagon-like peptide 1 on the hepatic glucose metabolism.” Horm Metab Res 36, no. 11–12 (November 2004): 837–41. https://doi.org/10.1055/s-2004-826172.
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    • Liu, Min, Ling Shen, Yin Liu, Stephen C. Woods, Randy J. Seeley, David D’Alessio, and Patrick Tso. “Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus.” Am J Physiol Endocrinol Metab 287, no. 2 (August 2004): E366–70. https://doi.org/10.1152/ajpendo.00448.2003.
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    • Abumrad, N., K. Clément, M. Meguid, D. D’Alessio, and L. Tappy. “Editorial introductions.” Current Opinion in Clinical Nutrition and Metabolic Care 7, no. 4 (July 1, 2004). https://doi.org/10.1097/01.mco.0000134369.86062.3a.
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    • Tappy, Luc, and David D’Alessio. “How are we going to understand (dys)regulation of glucose metabolism?” Curr Opin Clin Nutr Metab Care 7, no. 4 (July 2004): 467–69. https://doi.org/10.1097/01.mco.0000134367.84276.c2.
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    • D’Alessio, David A., and Torsten P. Vahl. “Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes.” Am J Physiol Endocrinol Metab 286, no. 6 (June 2004): E882–90. https://doi.org/10.1152/ajpendo.00014.2004.
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    • Seeley, Randy J., David A. D’Alessio, and Stephen C. Woods. “Fat hormones pull their weight in the CNS.” Nat Med 10, no. 5 (May 2004): 454–55. https://doi.org/10.1038/nm0504-454.
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    • Vahl, Torsten P., and David A. D’Alessio. “Gut peptides in the treatment of diabetes mellitus.” Expert Opinion on Investigational Drugs 13, no. 3 (March 2004): 177–88. https://doi.org/10.1517/13543784.13.3.177.
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    • Ehlers, M. R., L. J. Klaff, D. A. D’Alessio, R. Brazg, H. D. Kay, R. E. Harley, A. L. Mathisen, and R. Schneider. “Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.” Horm Metab Res 35, no. 10 (October 2003): 611–16. https://doi.org/10.1055/s-2003-43509.
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    • Ensinck, John W., Ellen C. Laschansky, Robin E. Vogel, and David A. D’Alessio. “Effect of ingested nutrients on the release of thrittene into the human circulation.” J Clin Endocrinol Metab 88, no. 10 (October 2003): 4798–4804. https://doi.org/10.1210/jc.2003-030063.
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    • Prigeon, Ronald L., Shaista Quddusi, Breay Paty, and David A. D’Alessio. “Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect.” Am J Physiol Endocrinol Metab 285, no. 4 (October 2003): E701–7. https://doi.org/10.1152/ajpendo.00024.2003.
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    • Henchoz, E., D. A. D’Alessio, M. Gillet, N. Halkic, O. Matzinger, J. -. J. Goy, R. Chioléro, L. Tappy, and P. Schneiter. “Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients.” Transplantation 76, no. 6 (September 27, 2003): 923–29. https://doi.org/10.1097/01.TP.0000079833.86120.85.
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    • Kinzig, Kimberly P., David A. D’Alessio, James P. Herman, Randall R. Sakai, Torsten P. Vahl, Helmer F. Figueiredo, Erin K. Murphy, and Randy J. Seeley. “CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors.” J Neurosci 23, no. 15 (July 16, 2003): 6163–70.
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    • Clegg, Deborah J., Stephen C. Benoit, Ellen L. Air, Alana Jackman, Patrick Tso, David D’Alessio, Stephen C. Woods, and Randy J. Seeley. “Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.” Endocrinology 144, no. 7 (July 2003): 2941–46. https://doi.org/10.1210/en.2002-0218.
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    • Vahl, Torsten, and David D’Alessio. “Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism.” Curr Opin Clin Nutr Metab Care 6, no. 4 (July 2003): 461–68. https://doi.org/10.1097/01.mco.0000078991.96795.84.
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    • Wortman, Matthew D., Deborah J. Clegg, David D’Alessio, Stephen C. Woods, and Randy J. Seeley. “C75 inhibits food intake by increasing CNS glucose metabolism.” Nat Med 9, no. 5 (May 2003): 483–85. https://doi.org/10.1038/nm0503-483.
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    • Brehm, Bonnie J., Randy J. Seeley, Stephen R. Daniels, and David A. D’Alessio. “A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women.” J Clin Endocrinol Metab 88, no. 4 (April 2003): 1617–23. https://doi.org/10.1210/jc.2002-021480.
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    • Vahl, Torsten P., Breay W. Paty, Bradley D. Fuller, Ronald L. Prigeon, and David A. D’Alessio. “Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans.” J Clin Endocrinol Metab 88, no. 4 (April 2003): 1772–79. https://doi.org/10.1210/jc.2002-021479.
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    • Woods, Stephen C., Randy J. Seeley, Paul A. Rushing, David D’Alessio, and Patrick Tso. “A controlled high-fat diet induces an obese syndrome in rats.” J Nutr 133, no. 4 (April 2003): 1081–87. https://doi.org/10.1093/jn/133.4.1081.
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    • Quddusi, Shaista, Torsten P. Vahl, Kevin Hanson, Ronald L. Prigeon, and David A. D’Alessio. “Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans.” Diabetes Care 26, no. 3 (March 2003): 791–98. https://doi.org/10.2337/diacare.26.3.791.
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    • Kinzig, Kimberly P., David A. D’Alessio, and Randy J. Seeley. “The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness.” J Neurosci 22, no. 23 (December 1, 2002): 10470–76.
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    • Ensinck, John W., Denis G. Baskin, Torsten P. Vahl, Robin E. Vogel, Ellen C. Laschansky, Bruce H. Francis, Ross C. Hoffman, et al. “Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation.” Endocrinology 143, no. 7 (July 2002): 2599–2609. https://doi.org/10.1210/endo.143.7.8904.
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    • Ensinck, John W., Denis G. Baskin, Torsten P. Vahl, Robin E. Vogel, Ellen C. Laschansky, Bruce H. Francis, Ross C. Hoffman, et al. “Thrittene, Homologous with Somatostatin-28(1-13), Is a Novel Peptide in Mammalian Gut and Circulation.” Endocrinology 143, no. 7 (July 1, 2002): 2599–2609. https://doi.org/10.1210/endo.143.7.8904.
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    • Greenbaum, Carla J., Ronald L. Prigeon, and David A. D’Alessio. “Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose.” Diabetes 51, no. 4 (April 2002): 951–57. https://doi.org/10.2337/diabetes.51.4.951.
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    • Tamashiro, Kellie L. K., Teruhiko Wakayama, Hidenori Akutsu, Yukiko Yamazaki, Jennifer L. Lachey, Matthew D. Wortman, Randy J. Seeley, et al. “Cloned mice have an obese phenotype not transmitted to their offspring.” Nat Med 8, no. 3 (March 2002): 262–67. https://doi.org/10.1038/nm0302-262.
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    • Rushing, P. A., M. M. Hagan, R. J. Seeley, T. A. Lutz, D. A. D’Alessio, E. L. Air, and S. C. Woods. “Inhibition of central amylin signaling increases food intake and body adiposity in rats.” Endocrinology 142, no. 11 (November 2001): 5035. https://doi.org/10.1210/endo.142.11.8593.
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    • D’Alessio, D. A., T. J. Kieffer, G. J. Taborsky, and P. J. Havel. “Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.” J Clin Endocrinol Metab 86, no. 3 (March 2001): 1253–59. https://doi.org/10.1210/jcem.86.3.7367.
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    • Verchere, C. B., D. A. D’Alessio, R. L. Prigeon, R. L. Hull, and S. E. Kahn. “The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.” Diabetes 49, no. 9 (September 2000): 1477–84. https://doi.org/10.2337/diabetes.49.9.1477.
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    • Seeley, R. J., K. Blake, P. A. Rushing, S. Benoit, J. Eng, S. C. Woods, and D. D’Alessio. “The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride.” J Neurosci 20, no. 4 (February 15, 2000): 1616–21.
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    • Seeley, R. J., S. C. Woods, and D. D’Alessio. “Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function.” Endocrinology 141, no. 2 (February 2000): 473–75. https://doi.org/10.1210/endo.141.2.7372.
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    • Greenbaum, C. J., R. L. Prigeon, and D. A. D’Alessio. “Abnormal incretin effect in subjects with "silent" type I diabetes.” Journal of Investigative Medicine 47, no. 2 (January 1, 1999).
    • Paty, B. W., D. Finegood, D. A. D’Alessio, and G. S. Meneilly. “Glucose metabolism in elderly patients with type 2 diabetes mellitus.” Journal of Investigative Medicine 47, no. 2 (January 1, 1999).
    • Hirsch, I. B., D. D’Alessio, L. Eng, C. Davis, A. Lernmark, and A. Chait. “Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro.” Diabetes Res Clin Pract 41, no. 3 (September 1998): 197–202. https://doi.org/10.1016/s0168-8227(98)00072-2.
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    • Thiele, T. E., R. J. Seeley, D. D’Alessio, J. Eng, I. L. Bernstein, S. C. Woods, and G. van Dijk. “Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.” Brain Res 801, no. 1–2 (August 10, 1998): 164–70. https://doi.org/10.1016/s0006-8993(98)00584-8.
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    • Owen, O. E., K. J. Smalley, D. A. D’Alessio, M. A. Mozzoli, and E. K. Dawson. “Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis.” Am J Clin Nutr 68, no. 1 (July 1998): 12–34. https://doi.org/10.1093/ajcn/68.1.12.
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    • Ensinck, J. W., R. E. Vogel, E. C. Laschansky, D. J. Koerker, R. L. Prigeon, S. E. Kahn, and D. A. D’Alessio. “Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.” J Clin Invest 100, no. 9 (November 1, 1997): 2295–2302. https://doi.org/10.1172/JCI119767.
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    • D’Alessio, D. “Peptide hormone regulation of islet cells.” Horm Metab Res 29, no. 6 (June 1997): 297–300. https://doi.org/10.1055/s-2007-979039.
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    • Verchere, C. B., D. A. D’Alessio, S. Wang, S. Andrikopoulos, and S. E. Kahn. “Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation.” Hormone and Metabolic Research = Hormon  Und Stoffwechselforschung = Hormones Et Metabolisme 29, no. 6 (June 1997): 311–16. https://doi.org/10.1055/s-2007-979042.
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    • Verchere, C. B., D. A. D’Alessio, R. D. Palmiter, G. C. Weir, S. Bonner-Weir, D. G. Baskin, and S. E. Kahn. “Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.” Proc Natl Acad Sci U S A 93, no. 8 (April 16, 1996): 3492–96. https://doi.org/10.1073/pnas.93.8.3492.
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    • D’Alessio, D. A., R. Vogel, R. Prigeon, E. Laschansky, D. Koerker, J. Eng, and J. W. Ensinck. “Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.” J Clin Invest 97, no. 1 (January 1, 1996): 133–38. https://doi.org/10.1172/JCI118380.
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    • D’Alessio, D. A., R. L. Prigeon, and J. W. Ensinck. “Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I.” Diabetes 44, no. 12 (December 1995): 1433–37. https://doi.org/10.2337/diab.44.12.1433.
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    • D’Alessio, D. A., C. B. Verchere, S. E. Kahn, V. Hoagland, D. G. Baskin, R. D. Palmiter, and J. W. Ensinck. “Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.” Diabetes 43, no. 12 (December 1994): 1457–61. https://doi.org/10.2337/diab.43.12.1457.
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    • Verchere, C. B., D. A. D’Alessio, R. D. Palmiter, and S. E. Kahn. “Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.” Diabetologia 37, no. 7 (July 1994): 725–28. https://doi.org/10.1007/BF00417699.
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    • D’Alessio, D. A., S. E. Kahn, C. R. Leusner, and J. W. Ensinck. “Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.” J Clin Invest 93, no. 5 (May 1994): 2263–66. https://doi.org/10.1172/JCI117225.
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    • Baskin, D. G., M. W. Schwartz, A. J. Sipols, D. A. D’Alessio, B. J. Goldstein, and M. F. White. “Insulin receptor substrate-1 (IRS-1) expression in rat brain.” Endocrinology 134, no. 4 (April 1994): 1952–55. https://doi.org/10.1210/endo.134.4.7511094.
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    • Kahn, S. E., C. B. Verchere, D. A. D’Alessio, D. L. Cook, and W. Y. Fujimoto. “Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway.” Diabetologia 36, no. 6 (June 1993): 570–73. https://doi.org/10.1007/BF02743276.
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    • Alessio, D. D., R. Thirlby, E. Laschansky, H. Zebroski, and J. Ensinck. “Response of tGLP-1 to nutrients in humans.” Digestion 54, no. 6 (January 1, 1993): 377–79. https://doi.org/10.1159/000201059.
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    • Boswell, T., R. D. Richardson, M. W. Schwartz, D. A. D’Alessio, S. C. Woods, A. J. Sipols, D. G. Baskin, and G. J. Kenagy. “NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding.” Brain Res Bull 32, no. 4 (1993): 379–84. https://doi.org/10.1016/0361-9230(93)90203-n.
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    • Ensinck, J. W., and D. A. D’Alessio. “The enteroinsular axis revisited. A novel role for an incretin.” N Engl J Med 326, no. 20 (May 14, 1992): 1352–53. https://doi.org/10.1056/NEJM199205143262009.
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    • Owen, O. E., M. A. Mozzoli, K. J. Smalley, E. C. Kavle, and D. A. D’Alessio. “Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals.” Am J Clin Nutr 55, no. 3 (March 1992): 630–36. https://doi.org/10.1093/ajcn/55.3.630.
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    • Kahn, S. E., W. Y. Fujimoto, D. A. D’Alessio, J. W. Ensinck, and D. Porte. “Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.” Horm Metab Res 23, no. 12 (December 1991): 577–80. https://doi.org/10.1055/s-2007-1003759.
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    • Ensinck, J. W., E. C. Laschansky, R. E. Vogel, and D. A. D’Alessio. “Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas.” Diabetes 40, no. 9 (September 1991): 1163–69. https://doi.org/10.2337/diab.40.9.1163.
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    • D’Alessio, D. A., and J. W. Ensinck. “Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men.” Diabetes 39, no. 10 (October 1990): 1198–1202. https://doi.org/10.2337/diab.39.10.1198.
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    • Kahn, S. E., D. A. D’Alessio, M. W. Schwartz, W. Y. Fujimoto, J. W. Ensinck, G. J. Taborsky, and D. Porte. “Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.” Diabetes 39, no. 5 (May 1990): 634–38. https://doi.org/10.2337/diab.39.5.634.
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    • Owen, O. E., K. J. Smalley, D. A. D’Alessio, M. A. Mozzoli, A. N. Knerr, Z. V. Kendrick, E. C. Kavle, M. Donohoe, L. Tappy, and G. Boden. “Resting metabolic rate and body composition of achondroplastic dwarfs.” Medicine (Baltimore) 69, no. 1 (January 1990): 56–67. https://doi.org/10.1097/00005792-199001000-00005.
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    • D’Alessio, D. A., W. Y. Fujimoto, and J. W. Ensinck. “Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures.” Diabetes 38, no. 12 (December 1989): 1534–38. https://doi.org/10.2337/diab.38.12.1534.
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    • D’Alessio, D. A., C. Sieber, C. Beglinger, and J. W. Ensinck. “A physiologic role for somatostatin 28 as a regulator of insulin secretion.” J Clin Invest 84, no. 3 (September 1989): 857–62. https://doi.org/10.1172/JCI114246.
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    • D’Alessio, D. A., E. C. Kavle, M. A. Mozzoli, K. J. Smalley, M. Polansky, Z. V. Kendrick, L. R. Owen, M. C. Bushman, G. Boden, and O. E. Owen. “Thermic effect of food in lean and obese men.” J Clin Invest 81, no. 6 (June 1988): 1781–89. https://doi.org/10.1172/JCI113520.
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    • Owen, O. E., J. L. Holup, D. A. D’Alessio, E. S. Craig, M. Polansky, K. J. Smalley, E. C. Kavle, M. C. Bushman, L. R. Owen, and M. A. Mozzoli. “A reappraisal of the caloric requirements of men.” Am J Clin Nutr 46, no. 6 (December 1987): 875–85. https://doi.org/10.1093/ajcn/46.6.875.
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  • Book Sections

    • Page, L. C., M. D. Miller, D. D’Alessio, and J. Tong. “Gastrointestinal hormones and the control of food intake and energy metabolism.” In Contemporary Endocrinology, 43–61, 2018. https://doi.org/10.1007/978-3-319-68192-4_3.
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    • Tong, J., D. Sandoval, and D. D’Alessio. “Textbook of Diabetes,” 2016.

  • Conference Papers

    • GILROY, CASLIN A., M. E. G. A. N. CAPOZZI, JONATHAN C. SU, J. E. N. N. Y. TONG, DAVID A. D’ALESSIO, J. O. N. A. T. H. A. N. CAMPBELL, and A. S. H. U. T. O. S. H. CHILKOTI. “1016-P: A Novel GLP-1 and FGF-21 Dual Agonist Drug Protects Mice from Obesity and Hyperglycemia.” In Diabetes, 68:1016-P. American Diabetes Association, 2019. https://doi.org/10.2337/db19-1016-p.
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    • Chatterjee, Ranee, Cris A. Slentz, Johanna L. Johnson, Pao Hwa Lin, Michael Muehlbauer, David A. D’Alessio, Laura P. Svetkey, and David Edelman. “A Pilot Study of Potassium Supplements on Glucose Metabolism in African-American Adults with Prediabetes.” In Diabetes, 66:A199–200. AMER DIABETES ASSOC, 2017.
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    • Coch, Reilly, Jonathan Campbell, and David A. D’Alessio. “The Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor Dapagliflozin Causes Ketosis In Nondiabetic and Diabetic Mice.” In Diabetes, 66:A349–A349. AMER DIABETES ASSOC, 2017.
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    • Douros, Jonathan, Jingjing Niu, Sophia Sdao, Trillian Gregg, Matthew J. Merrins, Jenny Tong, Jonathan Campbell, and David A. D’Alessio. “Does Bariatric Surgery Build Better Beta Cells? Vertical Sleeve Gastrectomy Stimulates Autonomous Improvements to Islet Function in Mice.” In Diabetes, 66:A12–A12. AMER DIABETES ASSOC, 2017.
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    • Encisco, Sara, Berit Svendsen, David A. D’Alessio, and Jonathan Campbell. “Glucagon Stimulates Insulin Secretion through Both Glucagon and GLP-1 Receptors.” In Diabetes, 66:A584–A584. AMER DIABETES ASSOC, 2017.
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    • Miller, Mark D., David A. D’Alessio, and Cris A. Slentz. “Beta-Cell Sensitivity to Incretin Infusions in Healthy Adults.” In Diabetes, 66:A26–A26. AMER DIABETES ASSOC, 2017.
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    • Niu, Jingjing, Jonathan Campbell, David A. D’Alessio, and Jenny Tong. “Ghrelin Suppresses Insulin Secretion More Potently under Low Glucose than High Glucose in Rodents.” In Diabetes, 66:A538–A538. AMER DIABETES ASSOC, 2017.
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    • Rosario, Wilfredo, David A. D’Alessio, and Christopher J. Rhodes. “Viral-Mediated GK Knockout in Specific Hypothalamic Nuclei Confirms Differential Regulation of Pancreatic Islet Physiology.” In Diabetes, 66:A500–A500. AMER DIABETES ASSOC, 2017.
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    • Telford, Onala, David A. D’Alessio, Adva Eisenberg, Rebecca Herbst, Beatrice Hong, William M. Bullock, Gavin Martin, Erin Manning, and Tracy Setji. “Perioperative Steroid Use for Knee and Hip Surgeries Increases Rates of Hyperglycemia but Is Associated with Reduced Length of Hospital Stays.” In Diabetes, 66:A454–A454. AMER DIABETES ASSOC, 2017.
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    • Chatha, Sheena, Adele E. Corbin, Erin M. Sisson, Kimberly M. Berger, Brittany Woolf, Anthony C. Leonard, David A. D’Alessio, and Mercedes Falciglia. “Management of Inpatient Hypoglycemia: Improving Safety through The Joint Commission Standards.” In Diabetes, 65:A330–A330. AMER DIABETES ASSOC, 2016.
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    • Polanco, Georgina G., Adele E. Corbin, Erin M. Sisson, Kathi B. Smith, Susan D. Brumm, David A. D’Alessio, and Mercedes Falciglia. “Sweet Transitions: Coordinating Diabetes Care between Hospital and Primary Care Settings.” In Diabetes, 65:A319–A319. AMER DIABETES ASSOC, 2016.
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    • An, Zhibo, Eric P. Smith, Todd Greer, Jose Berger, and David A. D’Alessio. “The Role of GLP-1 Receptor Signaling in Metabolic Changes after Roux-en-Y Gastric Bypass in Diet Induced Obese Rats.” In Diabetes, 61:A56–A56. AMER DIABETES ASSOC, 2012.
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    • Falciglia, Mercedes, Ron W. Freyberg, Peter L. Almenoff, David A. D’Alessio, and Marta L. Render. “Hyperglycemia during Critical Illness Predicts Future Diabetes.” In Diabetes, 61:A368–A368. AMER DIABETES ASSOC, 2012.
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    • Inge, Thomas H., Todd M. Jenkins, Deborah A. Elder, April N. Carr, Renee M. Jeffreys, Cynthia Spikes, Lawrence M. Dolan, Ronald L. Prigeon, and David A. D’Alessio. “Improved Insulin Sensitivity and Decreased Insulin Secretion in Adolescents Undergoing Gastric Bypass.” In Obesity, 18:S218–S218. NATURE PUBLISHING GROUP, 2010.
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    • Kindel, Tammy Lyn, Paulo J. F. Martins, Stephanie M. Yoder, Randy J. Seeley, David A. D’Alessio, Silvana Obici, and Patrick Tso. “Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents.” In Journal of the American College of Surgeons, 211:S16–17. Elsevier BV, 2010. https://doi.org/10.1016/j.jamcollsurg.2010.06.036.
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    • Burke, Katie T., David A. D’Alessio, and Laura A. Woollett. “Multiparity Programs Offspring To Have Increased Adiposity.” In Diabetes, 59:A476–A476. AMER DIABETES ASSOC, 2010.
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    • Elder, Deborah A., Jessica G. Woo, and David A. D’Alessio. “Longitudinal Assessment of Beta-Cell Function in Adolescents Newly Diagnosed with T2DM Compared to Weight Matched Controls: Two Year Assessment.” In Diabetes, 59:A6–7. AMER DIABETES ASSOC, 2010.
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    • Salehi, Marzieh, Ronald L. Prigeon, and David A. D’Alessio. “Postprandial Insulin Secretion and Clearance in Patients with Hyperinsulinemic Hypoglycemic Syndrome Following Gastric Bypass Surgery.” In Diabetes, 59:A657–A657. AMER DIABETES ASSOC, 2010.
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    • D’Alessio, David. “Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV.” In Jpen J Parenter Enteral Nutr, 32:567–68, 2008. https://doi.org/10.1177/0148607108322401.
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    • Aulinger, Benedikt A., Jonathan Hassel, Kyle Roy, Eileen E. Elfers, Stephen C. Woods, Randy J. Seeley, and David A. D’Alessio. “Peripheral effects of Ex-4 and GLP-1 on anorexia and weight loss.” In Diabetes, 57:A435–A435. AMER DIABETES ASSOC, 2008.
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    • Aulinger, Benedikt A., Marta Perabo, Jonathan Has-Sel, Diego Perez-Ptilve, Eileen E. Elfers, Matthias H. Tschop, Randy J. Seeley, and David A. D’Alessio. “Ex-4 and the DPP-IV inhibitor vildagliptin have additive effects to suppress food intake in rodents.” In Diabetes, 57:A433–A433. AMER DIABETES ASSOC, 2008.
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    • Elder, Deborah A., Jessica G. Woo, Lawrence M. Dolan, and David A. D’alessio. “Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes.” In Diabetes, 57:A67–A67. AMER DIABETES ASSOC, 2008.
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    • Salehi, Marzieh, and David A. D’Alessio. “Intraindividual variation of the incretin-related insulin response during oral glucose tolerance test.” In Diabetes, 57:A415–A415. AMER DIABETES ASSOC, 2008.
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    • Summer, Suzanne S., Bonnie J. Brehm, Stephen C. Benoit, and David A. D’Alessio. “The effects of diet composition and weight loss on serum adiponectin.” In Diabetes, 57:A103–A103. AMER DIABETES ASSOC, 2008.
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    • Aulinger, Benedikt A., Torsten P. Vahl, Eileen E. Elfers, Clinton T. Elfers, and David A. D’Alessio. “Antagonists of the GLP-1 receptor, ex-9 and dHis-Ex, block GIP action in vitro but not in vivo.” In Diabetes, 56:A672–73. AMER DIABETES ASSOC, 2007.
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    • Brehm, Bonnie J., Barbara L. Lattin, Suzanne S. Summer, Jane A. Boback, Gina M. Gilchrist, and David A. D’Alessio. “High monounsaturated fat and high carbohydrate diets are equally effective and acceptable in overweight and obese subjects with type 2 diabetes.” In Diabetes, 56:A17–A17. AMER DIABETES ASSOC, 2007.
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    • Crimmins, Nancy A., Jane C. Khoury, Stepen R. Daniels, David A. D’Alessio, Lawrence M. Dolan, and Shelley Kirk. “Overweight youth: Low prevalence of glucose intolerance and diabetes.” In Diabetes, 56:A470–A470. AMER DIABETES ASSOC, 2007.
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    • Elder, Deborah A., David A. D’Alessio, and Susan R. Rose. “Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion.” In Diabetes, 56:A700–A700. AMER DIABETES ASSOC, 2007.
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    • Elder, Deborah A., Torsten Vahl, Lawrence M. Dolan, and David A. D’Alessio. “The incretin effect in adolescents with type 2 diabetes is not impaired.” In Diabetes, 56:A75–A75. AMER DIABETES ASSOC, 2007.
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    • Falciglia, Mercedes, Ron W. Freyberg, Peter L. Almenoff, David A. D’Alessio, and Marta L. Render. “Severity of illness is not a major determinant of hyperglycemia in critically ill patients.” In Diabetes, 56:A177–A177. AMER DIABETES ASSOC, 2007.
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    • Klustaitis, Kori M., Eileen E. Elfers, and David A. D’Alessio. “Sensory neurons in the portal vein can access small molecules in circulation: Support for a neuro-endocrine mechanism of action of GLP-1.” In Diabetes, 56:A378–A378. AMER DIABETES ASSOC, 2007.
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    • Ryan, Karen K., Benedikt A. Aulinger, David A. D’Alessio, Randy J. Seeley, and Stephen C. Woods. “Scheduled feeding improves postprandial glucose tolerance.” In Diabetes, 56:A682–A682. AMER DIABETES ASSOC, 2007.
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    • Salehi, Marzieh, Benedikt A. Aulinger, and David A. D’Alessio. “The role of glucagon-like peptide-1 to stimulate postprandial insulin secretion in type 2 diabetes.” In Diabetes, 56:A385–86. AMER DIABETES ASSOC, 2007.
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    • Brehm, Bonnie J., Barbara L. Lattin, Suzanne S. Summer, Jane A. Boback, Gina M. Gilchrist, and David A. D’Alessio. “Randomized one-year comparison of high monounsaturated fat and high carbohydrate diets in subjects with type 2 diabetes.” In Diabetes, 55:A381–A381. AMER DIABETES ASSOC, 2006.
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    • Crimmins, Nancy A., Judy A. Bean, Stephen R. Daniels, David A. D’Alessio, and Lawrence M. Dolan. “Infrequent abnormalities of carbohydrate metabolism despite high rates of obesity and insulin resistance in a longitudinal study of adolescents.” In Diabetes, 55:A68–A68. AMER DIABETES ASSOC, 2006.
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    • D’Alessio, David A., Catherine E. Watson, Yan-Ling He, Monica Ligueros-Saylan, Yibin Wang, Beth E. Dunning, Ronald L. Prigeon, James E. Foley, and Richard E. Pratley. “Restoration of an acute insulin response to glucose (AIRg) in drug-naive patients with type diabetes (T2DM) by 3-month treatment with vildagliptin.” In Diabetes, 55:A108–A108. AMER DIABETES ASSOC, 2006.
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    • Salehi, Marzieh, Horacio L. Rilo, Syed A. Ahmad, Jeffery B. Matthews, Andrew M. Lowy, and David A. D’Alessio. “Stability of insulin secretion following islet autotransplantation.” In Diabetes, 55:A448–A448. AMER DIABETES ASSOC, 2006.
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    • Salehi, Marzieh, Torsten Vahl, and David A. D’Alessio. “Effect of endogenous GLP-1 on insulin secretion during oral glucose tolerance tests.” In Diabetes, 55:A324–A324. AMER DIABETES ASSOC, 2006.
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    • Vahl, Torsten P., Deborah L. Drazen, Randy J. Seeley, David A. D’Alessio, and Stephen C. Woods. “Improved glucose tolerance in meal-fed rats is not regulated by GLP-1 or GIP.” In Diabetes, 55:A342–A342. AMER DIABETES ASSOC, 2006.
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    • Teff, Karen L., Sharon S. Elliott, Matthias Tschöp, Timothy J. Kieffer, Daniel Rader, Mark Heiman, Raymond R. Townsend, Nancy L. Keim, David D’Alessio, and Peter J. Havel. “Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.” In J Clin Endocrinol Metab, 89:2963–72, 2004. https://doi.org/10.1210/jc.2003-031855.
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    • Rodriguez Rilo, Horacio L., Syed A. Ahmad, David D’Alessio, Yasuhiro Iwanaga, Joseph Kim, Kyuran A. Choe, Jonathan S. Moulton, et al. “Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis.” In J Gastrointest Surg, 7:978–89, 2003. https://doi.org/10.1016/j.gassur.2003.09.008.
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    • D’Alessio, D. “Glucagon-like peptide 1 (GLP-1) in diabetes and aging.” In Journal of Anti Aging Medicine, 3:329–33, 2000. https://doi.org/10.1089/rej.1.2000.3.329.
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    • Paty, B. W., J. Teague, and D. A. D’Alessio. “Effects of GLP-1 [9-36] NH2, a metabolite of GLP-1 [7-36] NH2, on insulin secretion in Hamster Insulinoma Tumor (HIT) cells.” In Investigative Ophthalmology and Visual Science, Vol. 37, 1996.

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