Current Appointments & Affiliations
Lindquist Presidential Distinguished Chair
·
2024 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Professor of Medicine
·
2015 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Chief, Division of Endocrinology and Metabolism
·
2014 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Duke Molecular Physiology Institute
·
2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion.
Journal Article Sci Adv · September 19, 2025 α cells secrete proglucagon peptides to regulate nutrient metabolism. Recent findings support an α cell-to-β cell axis that is mediated by paracrine signaling through the glucagon receptor and glucagon-like peptide 1 (GLP-1) receptor in β cells. To address ... Full text Link to item Citeβ Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion.
Journal Article J Clin Invest · August 15, 2025 The incretin peptides glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors coordinate β cell secretion that is proportional to nutrient intake. This effect permits consistent and restricted glucose excursions across a range of ... Full text Link to item CiteNIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Longevity.
Journal Article Diabetes Care · July 1, 2025 Full text Link to item CiteRecent Grants
Metabolic Actions of Glucagon
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2030Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029Alpha- to Beta-Cell Communication in Health and Disease
ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
1983
M.D.