Current Duke Appointments & Affiliations
Lindquist Presidential Distinguished Chair
·
2024 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Professor of Medicine
·
2015 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Chief, Division of Endocrinology and Metabolism
·
2014 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Member of Duke Molecular Physiology Institute
·
2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Scholarly Works
Glucagon promotes net hepatic glycogen repletion following meal ingestion.
Journal article JCI Insight · April 22, 2026 Insulin and glucagon are described as having opposing actions on hepatic glycogen metabolism. However, here we showed that their coordinated action promoted glycogen turnover and meal glucose storage. In mice, pharmacological doses of insulin or glucagon f ... Full text Link to item CiteCardiovascular Outcomes with Tirzepatide in Type 2 Diabetes. Reply.
Journal article N Engl J Med · April 16, 2026 Full text Link to item CiteEctopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues.
Journal article Mol Metab · March 2026 OBJECTIVES: Unimolecular triagonists drive substantial weight loss in patients with obesity by engaging the glucagon-like peptide 1 receptor (GLP-1R) and glucose dependent insulinotropic polypeptide receptor (GIPR) to reduce food intake (FI) and the hepati ... Full text Link to item CiteRecent Grants
Metabolic Actions of Glucagon
ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2030A gut sense for dietary lysine
ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2030Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029View All Grants
Education
University of Wisconsin, Madison ·
1983
M.D.