David A D'Alessio
Professor of Medicine
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2015
- Chief, Division of Endocrinology and Metabolism, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2014
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2014
Contact Information
- 300 North Duke Street, Durham, NC 27701
- DUMC Box 104775, Durham, NC 27710
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david.d'alessio@duke.edu
(919) 684-4005
- Background
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Education, Training, & Certifications
- Research Fellowship, Metabolism, Endocrinology And Nutrition, University of Washington School of Medicine 1987 - 1990
- Resident, Temple University School of Medicine 1983 - 1986
- M.D., University of Wisconsin at Madison 1983
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Duke Appointment History
- Instructor Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2014 - 2015
- Research
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Selected Grants
- Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents awarded by National Institutes of Health 2018 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- The Role of Islet DPP4 for Regulation of Glucose Homeostasis awarded by National Institutes of Health 2018 - 2021
- Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- vTv awarded by vTv Therapeutics LLC 2018 - 2020
- Assessing the Role of Glucose-Dependent Insulinotropic Polypeptide to Mediate Improved Beta-Cell Function Following Bariatric Surgery awarded by National Institutes of Health 2017 - 2019
- Role of Islet GLP-1 and DPP-4 in Insulin Secretion awarded by Merck Sharp & Dohme 2015 - 2019
- IPA - Andrew Hoselton awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- IPA - Cris Slentz awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- IPA - Lorraine Elliott-Penry awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- IPA - Lucy Piner awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- IPA - Radha Krishna awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- IPA- Leslie Kelly awarded by Durham Veterans Affairs Medical Center 2017 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- INCRETIN ACTION IN PHYSIOLOGY AND DIABETES awarded by National Institutes of Health 2014 - 2019
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
- The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes awarded by National Institutes of Health 2013 - 2019
- The Role of Vitamin D in Established Type 2 Diabetes awarded by Tufts Medical Center 2015 - 2018
- Ligand L6972-04 Type 2 Diabetes Study awarded by Ligand Pharmaceuticals, Inc. 2016 - 2017
- The Role of Glucagon in Diabetic Ketoacidosis awarded by Endocrine Fellows Foundation 2016 - 2017
- Publications & Artistic Works
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Selected Publications
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Books
- Kirk, S, Brehm, B, Saelens, BE, Woo, JG, Kissel, E, D'Alessio, D, Bolling, C, and Daniels, SR. Role of carbohydrate modification in weight management among obese children: A randomized clinical trial. January 1, 2014. Full Text
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Academic Articles
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery." Gut (February 16, 2019). Full Text
- Shariff, AI, Syed, S, Shelby, RA, Force, J, Clarke, JM, D'Alessio, D, and Corsino, L. "Novel cancer therapies and their association with diabetes." Journal of Molecular Endocrinology 62, no. 2 (February 2019): R187-R199. (Review) Full Text
- Coskun, T, Sloop, KW, Loghin, C, Alsina-Fernandez, J, Urva, S, Bokvist, KB, Cui, X, Briere, DA, Cabrera, O, Roell, WC, Kuchibhotla, U, Moyers, JS, Benson, CT, Gimeno, RE, D'Alessio, DA, and Haupt, A. "LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept." Molecular Metabolism 18 (December 2018): 3-14. Full Text
- Davies, MJ, D'Alessio, DA, Fradkin, J, Kernan, WN, Mathieu, C, Mingrone, G, Rossing, P, Tsapas, A, Wexler, DJ, and Buse, JB. "Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)." Diabetes Care 41, no. 12 (December 2018): 2669-2701. Full Text
- Rivero-Gutierrez, B, Haller, A, Holland, J, Yates, E, Khrisna, R, Habegger, K, Dimarchi, R, D'Alessio, D, and Perez-Tilve, D. "Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia." Molecular Metabolism 17 (November 2018): 28-38. Full Text
- Page, LC, Gastaldelli, A, Gray, SM, D'Alessio, DA, and Tong, J. "Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans." Diabetes 67, no. 10 (October 2018): 1976-1985. Full Text
- Buse, JB, D'Alessio, DA, and Riddle, MC. "Can We RISE to the Challenge of Youth-Onset Type 2 Diabetes?." Diabetes Care 41, no. 8 (August 2018): 1560-1562. Full Text
- Douros, JD, Lewis, AG, Smith, EP, Niu, J, Capozzi, M, Wittmann, A, Campbell, J, Tong, J, Wagner, C, Mahbod, P, Seeley, R, and D'Alessio, DA. "Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor." Diabetes 67, no. 8 (August 2018): 1504-1511. Full Text
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Beta-cell sensitivity to glucose is impaired after gastric bypass surgery." Diabetes, Obesity & Metabolism 20, no. 4 (April 2018): 872-878. Full Text Open Access Copy
- Nunez, DJ, and D'Alessio, D. "Glucagon receptor as a drug target: A witches' brew of eye of newt (peptides) and toe of frog (receptors)." Diabetes, Obesity & Metabolism 20, no. 2 (February 2018): 233-237. Full Text Open Access Copy
- Angellotti, E, D'Alessio, D, Dawson-Hughes, B, Chu, Y, Nelson, J, Hu, P, Cohen, RM, and Pittas, AG. "Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes(Accepted)." Clinical Nutrition (January 1, 2018). Full Text
- Crowley, MJ, Williams, JW, Kosinski, AS, D'Alessio, DA, and Buse, JB. "Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes." Diabetes Care 40, no. 12 (December 2017): 1787-1789. Full Text
- Elder, DA, Hornung, LN, Khoury, JC, and D'Alessio, DA. "β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes." The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine 61, no. 6 (December 2017): 703-708. Full Text
- Jessen, L, Smith, EP, Ulrich-Lai, Y, Herman, JP, Seeley, RJ, Sandoval, D, and D'Alessio, D. "Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats." Endocrinology 158, no. 7 (July 2017): 2124-2133. Full Text
- Chambers, AP, Sorrell, JE, Haller, A, Roelofs, K, Hutch, CR, Kim, K-S, Gutierrez-Aguilar, R, Li, B, Drucker, DJ, D'Alessio, DA, Seeley, RJ, and Sandoval, DA. "The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice." Cell Metabolism 25, no. 4 (April 2017): 927-934.e3. Full Text
- Campbell, JE, and D'Alessio, DA. "DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain." The Journal of clinical investigation 127, no. 3 (March 2017): 793-795. Full Text
- Zhang, CJ, Bidlingmaier, M, Altaye, M, Page, LC, D'Alessio, D, Tschöp, MH, and Tong, J. "Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans." European Journal of Endocrinology 176, no. 2 (February 2017): 123-132. Full Text
- Cefalu, WT, Boulton, AJM, Tamborlane, WV, Moses, RG, LeRoith, D, Greene, EL, Hu, FB, Bakris, G, Wylie-Rosett, J, Rosenstock, J, Kahn, SE, Weinger, K, Blonde, L, de Groot, M, Rich, S, D’Alessio, D, Reynolds, L, and Riddle, MC. "Diabetes Care: “Taking It to the Limit One More Time”." Diabetes Care 40, no. 1 (January 2017): 3-6. Full Text
- Ghosal, S, Packard, AEB, Mahbod, P, McKlveen, JM, Seeley, RJ, Myers, B, Ulrich-Lai, Y, Smith, EP, D'Alessio, DA, and Herman, JP. "Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 37, no. 1 (January 2017): 184-193. Full Text
- Luginbuhl, KM, Schaal, JL, Umstead, B, Mastria, EM, Li, X, Banskota, S, Arnold, S, Feinglos, M, D'Alessio, D, and Chilkoti, A. "One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer." Nature Biomedical Engineering 1 (January 2017). Full Text
- Myers, MG. "A Few Words of Introduction From Your New Diabetes Editorial Board." Diabetes 66, no. 1 (January 2017): 3-4. Full Text
- Wysham, C, Guerci, B, D'Alessio, D, Jia, N, and Botros, FT. "Baseline factors associated with glycaemic response to treatment with once-weekly dulaglutide in patients with type 2 diabetes." Diabetes, Obesity & Metabolism 18, no. 11 (November 2016): 1138-1142. Full Text
- Alzaman, NS, Dawson-Hughes, B, Nelson, J, D'Alessio, D, and Pittas, AG. "Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation." The American Journal of Clinical Nutrition 104, no. 1 (July 2016): 205-214. Full Text
- Cefalu, WT, Boulton, AJM, Tamborlane, WV, Moses, RG, LeRoith, D, Greene, EL, Hu, FB, Bakris, G, Wylie-Rosett, J, Rosenstock, J, Weinger, K, Blonde, L, de Groot, M, Rich, SS, D’Alessio, D, Riddle, MC, and Reynolds, L. "Diabetes Care: “Lagniappe” and “Seeing Is Believing”!." Diabetes Care 39, no. 7 (July 2016): 1069-1071. Full Text
- Salehi, M, and D'Alessio, DA. "Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe." Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery 12, no. 6 (July 2016): 1230-1235. (Review) Full Text
- Shah, AS, D'Alessio, D, Ford-Adams, ME, Desai, AP, and Inge, TH. "Bariatric Surgery: A Potential Treatment for Type 2 Diabetes in Youth." Diabetes Care 39, no. 6 (June 2016): 934-940. (Review) Full Text
- Tong, J, Davis, HW, Gastaldelli, A, and D'Alessio, D. "Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1." The Journal of Clinical Endocrinology and Metabolism 101, no. 6 (June 2016): 2405-2414. Full Text
- Wolfe, BM, and D'Alessio, DA. "Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care." Obesity (Silver Spring, Md.) 24, no. 6 (June 2016): 1205-1206. Full Text
- Aulinger, BA, Vahl, TP, Prigeon, RL, D'Alessio, DA, and Elder, DA. "The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?." American Journal of Physiology. Endocrinology and Metabolism 310, no. 9 (May 2016): E774-E781. Full Text
- D'Alessio, D. "Is GLP-1 a hormone: Whether and When?." Journal of Diabetes Investigation 7 Suppl 1 (April 2016): 50-55. (Review) Full Text
- Cefalu, WT, Boulton, AJM, Tamborlane, WV, Moses, RG, LeRoith, D, Greene, EL, Hu, FB, Bakris, G, Wylie-Rosett, J, Rosenstock, J, Weinger, K, Blonde, L, de Groot, M, Riddle, MC, Hill Golden, S, Rich, SS, D'Alessio, D, and Reynolds, L. "Building Momentum: Taking on the Real “Issues” of Diabetes Care!." Diabetes Care 39, no. 1 (January 2016): 10-12. Full Text
- Gibb, RD, McRorie, JW, Russell, DA, Hasselblad, V, and D'Alessio, DA. "Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus." The American Journal of Clinical Nutrition 102, no. 6 (December 2015): 1604-1614. Full Text
- Inge, TH, Prigeon, RL, Elder, DA, Jenkins, TM, Cohen, RM, Xanthakos, SA, Benoit, SC, Dolan, LM, Daniels, SR, and D'Alessio, DA. "Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents." The Journal of pediatrics 167, no. 5 (November 2015): 1042-8.e1. Full Text
- Ghosal, S, Nunley, A, Mahbod, P, Lewis, AG, Smith, EP, Tong, J, D'Alessio, DA, and Herman, JP. "Mouse handling limits the impact of stress on metabolic endpoints." Physiology & behavior 150 (October 2015): 31-37. Full Text
- Salehi, M, Woods, SC, and D'Alessio, DA. "Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion." Obesity (Silver Spring, Md.) 23, no. 10 (October 2015): 2046-2052. Full Text
- Beamish, AJ, D'Alessio, DA, and Inge, TH. "Controversial Issues: When the drugs don't work, can surgery provide a different outcome for diabetic adolescents?." Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 11, no. 4 (July 2015): 946-948. (Review) Full Text
- Beamish, AJ, D'Alessio, DA, and Inge, TH. "Controversial Issues: When the drugs don't work, can surgery provide a different outcome for diabetic adolescents?." Surgery for Obesity and Related Diseases 11, no. 4 (July 1, 2015): 946-948. (Review) Full Text
- Begg, DP, May, AA, Mul, JD, Liu, M, D'Alessio, DA, Seeley, RJ, and Woods, SC. "Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin." Diabetes 64, no. 7 (July 2015): 2457-2466. Full Text
- Koska, J, Sands, M, Burciu, C, D'Souza, KM, Raravikar, K, Liu, J, Truran, S, Franco, DA, Schwartz, EA, Schwenke, DC, D'Alessio, D, Migrino, RQ, and Reaven, PD. "Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans." Diabetes 64, no. 7 (July 2015): 2624-2635. Full Text
- Rosario, W, and D'Alessio, D. "An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes." Diabetes 64, no. 7 (July 2015): 2329-2331. Full Text
- Tong, J, and D'Alessio, D. "Surgical Treatment of Diabetes: Making a Case for a Pragmatic Approach." The Journal of Clinical Endocrinology and Metabolism 100, no. 7 (July 2015): 2536-2538. Full Text
- Aulinger, BA, Vahl, TP, Wilson-Pérez, HE, Prigeon, RL, and D'Alessio, DA. "β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity." The Journal of Clinical Endocrinology and Metabolism 100, no. 6 (June 2015): 2489-2496. Full Text
- Müller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Diéguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO, van der Lely, AJ, van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, T, and Tschöp, MH. "Ghrelin." Molecular Metabolism 4, no. 6 (June 2015): 437-460. (Review) Full Text Open Access Copy
- Ottaway, N, Mahbod, P, Rivero, B, Norman, LA, Gertler, A, D'Alessio, DA, and Perez-Tilve, D. "Diet-induced obese mice retain endogenous leptin action." Cell Metabolism 21, no. 6 (June 2015): 877-882. Full Text
- Sandoval, DA, and D'Alessio, DA. "Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease." Physiological Reviews 95, no. 2 (April 2015): 513-548. (Review) Full Text
- Elder, DA, Hornung, LN, Herbers, PM, Prigeon, R, Woo, JG, and D'Alessio, DA. "Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes." The Journal of Pediatrics 166, no. 3 (March 2015): 672-678. Full Text
- D'Alessio, D, Häring, H-U, Charbonnel, B, de Pablos-Velasco, P, Candelas, C, Dain, M-P, Vincent, M, Pilorget, V, Yki-Järvinen, H, and EAGLE Investigators, . "Comparison of insulin glargine and liraglutide added to oral agents in patients with poorly controlled type 2 diabetes." Diabetes, obesity & metabolism 17, no. 2 (February 2015): 170-178. Full Text
- Tong, J, and D'Alessio, D. "Ghrelin and hypothalamic development: too little and too much of a good thing." The Journal of Clinical Investigation 125, no. 2 (February 2015): 490-492. Full Text
- Elder, DA, Hornung, LN, Herbers, PM, Prigeon, R, Woo, JG, and D'Alessio, DA. "Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes." Journal of Pediatrics 166, no. 3 (January 1, 2015): 672-678. Full Text
- Vahl, TP, Aulinger, BA, Smith, EP, Drazen, DL, Ulrich-Lai, Y, Seeley, RJ, Woods, SC, and D'Alessio, DA. "Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia." American Journal of Physiology. Endocrinology and Metabolism 307, no. 9 (November 2014): E784-E792. Full Text
- Salehi, M, and D'Alessio, DA. "Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery." Reviews in Endocrine & Metabolic Disorders 15, no. 3 (September 2014): 171-179. (Review) Full Text
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion." Diabetologia 57, no. 7 (July 2014): 1495-1499. Full Text
- Tong, J, Davis, HW, Summer, S, Benoit, SC, Haque, A, Bidlingmaier, M, Tschöp, MH, and D'Alessio, D. "Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans." Diabetes 63, no. 7 (July 2014): 2309-2319. Full Text Open Access Copy
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia." The Journal of Clinical Endocrinology and Metabolism 99, no. 6 (June 2014): 2008-2017. Full Text
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Beta-Cell Response to Graded up & Down Glucose Infusion after Gastric Bypass Surgery." ENDOCRINE REVIEWS 35, no. 3 (June 2014). Link to Item
- Sisley, S, Gutierrez-Aguilar, R, Scott, M, D'Alessio, DA, Sandoval, DA, and Seeley, RJ. "Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect." The Journal of Clinical Investigation 124, no. 6 (June 2014): 2456-2463. Full Text
- Smith, EP, An, Z, Wagner, C, Lewis, AG, Cohen, EB, Li, B, Mahbod, P, Sandoval, D, Perez-Tilve, D, Tamarina, N, Philipson, LH, Stoffers, DA, Seeley, RJ, and D'Alessio, DA. "The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs." Cell Metabolism 19, no. 6 (June 2014): 1050-1057. Full Text
- Gastaldelli, A, Brodows, RG, and D'Alessio, D. "The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes." Clinical Endocrinology 80, no. 4 (April 2014): 545-553. Full Text
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass." Gastroenterology 146, no. 3 (March 2014): 669-680.e2. Full Text
- Chambers, AP, Smith, EP, Begg, DP, Grayson, BE, Sisley, S, Greer, T, Sorrell, J, Lemmen, L, LaSance, K, Woods, SC, Seeley, RJ, D'Alessio, DA, and Sandoval, DA. "Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy." American Journal of Physiology. Endocrinology and Metabolism 306, no. 4 (February 2014): E424-E432. Full Text
- Gutierrez-Aguilar, R, Kim, D-H, Casimir, M, Dai, X-Q, Pfluger, PT, Park, J, Haller, A, Donelan, E, Park, J, D'Alessio, D, Woods, SC, MacDonald, PE, and Seeley, RJ. "The role of the transcription factor ETV5 in insulin exocytosis." Diabetologia 57, no. 2 (February 2014): 383-391. Full Text
- Habegger, KM, Heppner, KM, Amburgy, SE, Ottaway, N, Holland, J, Raver, C, Bartley, E, Müller, TD, Pfluger, PT, Berger, J, Toure, M, Benoit, SC, Dimarchi, RD, Perez-Tilve, D, D'Alessio, DA, Seeley, RJ, and Tschöp, MH. "GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats." Diabetes 63, no. 2 (February 2014): 505-513. Full Text
- Tong, J, and D'Alessio, D. "Give the receptor a brake: slowing gastric emptying by GLP-1." Diabetes 63, no. 2 (February 2014): 407-409. Full Text
- "Effects of glucagon like peptide-1 to mediate glycemic effects of weight loss surgery." Reviews in Endocrine and Metabolic Disorders 15, no. 3 (January 1, 2014): 171-179. (Review) Full Text
- Salehi, M, Gastaldelli, A, and D'Alessio, DA. "Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion." Diabetologia 57, no. 7 (January 1, 2014): 1495-1499. Full Text
- An, Z, Prigeon, RL, and D'Alessio, DA. "Improved glycemic control enhances the incretin effect in patients with type 2 diabetes." The Journal of Clinical Endocrinology and Metabolism 98, no. 12 (December 2013): 4702-4708. Full Text
- Clemmensen, C, Smajilovic, S, Smith, EP, Woods, SC, Bräuner-Osborne, H, Seeley, RJ, D'Alessio, DA, and Ryan, KK. "Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice." Endocrinology 154, no. 11 (November 2013): 3978-3983. Full Text
- Lehti, M, Donelan, E, Abplanalp, W, Al-Massadi, O, Habegger, KM, Weber, J, Ress, C, Mansfeld, J, Somvanshi, S, Trivedi, C, Keuper, M, Ograjsek, T, Striese, C, Cucuruz, S, Pfluger, PT, Krishna, R, Gordon, SM, Silva, RAGD, Luquet, S, Castel, J, Martinez, S, D'Alessio, D, Davidson, WS, and Hofmann, SM. "High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice." Circulation 128, no. 22 (November 2013): 2364-2371. Full Text
- Salehi, M, and D'Alessio, DA. "Going with the flow: adaptation of β-cell function to glucose fluxes after bariatric surgery." Diabetes 62, no. 11 (November 2013): 3671-3673. Full Text
- Salehi, M, and D'Alessio, DA. "With the Flow: Adaptation of beta-Cell Function to Glucose Fluxes After Bariatric Surgery." DIABETES 62, no. 11 (November 2013): 3671-3673. Full Text Link to Item
- Schwartz, MW, Seeley, RJ, Tschöp, MH, Woods, SC, Morton, GJ, Myers, MG, and D'Alessio, D. "Cooperation between brain and islet in glucose homeostasis and diabetes." Nature 503, no. 7474 (November 2013): 59-66. (Review) Full Text
- Habegger, KM, Kirchner, H, Yi, C-X, Heppner, KM, Sweeney, D, Ottaway, N, Holland, J, Amburgy, S, Raver, C, Krishna, R, Müller, TD, Perez-Tilve, D, Pfluger, PT, Obici, S, DiMarchi, RD, D'Alessio, DA, Seeley, RJ, and Tschöp, MH. "GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats." Diabetes 62, no. 9 (September 2013): 3261-3267. Full Text
- Rosenstock, J, Rodbard, HW, Bain, SC, D'Alessio, D, Seufert, J, Thomsen, AB, Svendsen, CB, DeVries, JH, and Liraglutide-Detemir Study Group, . "One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target." Journal of diabetes and its complications 27, no. 5 (September 2013): 492-500. Full Text
- Sandoval, D, Dunki-Jacobs, A, Sorrell, J, Seeley, RJ, and D'Alessio, DD. "Impact of intestinal electrical stimulation on nutrient-induced GLP-1 secretion in vivo." Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 25, no. 8 (August 2013): 700-705. Full Text
- Koska, J, Raravikar, K, Schwenke, DC, D'Alessio, DA, and Reaven, PD. "Direct Effect of Exenatide on Endothelial Function in Humans." DIABETES 62 (July 2013): A260-A260. Link to Item
- Mahbod, P, Smith, E, Wagner, C, Lewis, AG, Benoit, SC, Elmquist, JK, Zigman, JM, D'Alessio, DA, and Tong, J. "Ghrelin Signaling in the Central Nervous System and/or beta-Cells Is Important for the Regulation of Insulin Secretion and Glucose Tolerance in Mice." DIABETES 62 (July 2013): A511-A511. Link to Item
- Mul, JD, Begg, DP, Barrera, JG, Li, B, Matter, EK, D'Alessio, DA, Woods, SC, Seeley, RJ, and Sandoval, DA. "High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 305, no. 1 (July 2013): R68-R77. Full Text
- Salehi, M, and D'Alessio, DA. "Neurally Induced Postprandial Insulin Secretion Is Enhanced Similarly in Patients With and Without Hypoglycemia after Gastric Bypass Surgery." DIABETES 62 (July 2013): A39-A39. Link to Item
- Tong, J, Dave, N, Mugundu, GM, Davis, HW, Gaylinn, BD, Thorner, MO, Tschöp, MH, D'Alessio, D, and Desai, PB. "The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects." European journal of endocrinology 168, no. 6 (June 2013): 821-828. Full Text
- Tong, J, Prigeon, RL, Davis, HW, Bidlingmaier, M, Tschöp, MH, and D'Alessio, D. "Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans." The Journal of Clinical Endocrinology and Metabolism 98, no. 6 (June 2013): 2536-2543. Full Text
- Habegger, KM, Stemmer, K, Cheng, C, Müller, TD, Heppner, KM, Ottaway, N, Holland, J, Hembree, JL, Smiley, D, Gelfanov, V, Krishna, R, Arafat, AM, Konkar, A, Belli, S, Kapps, M, Woods, SC, Hofmann, SM, D'Alessio, D, Pfluger, PT, Perez-Tilve, D, Seeley, RJ, Konishi, M, Itoh, N, Kharitonenkov, A, Spranger, J, DiMarchi, RD, and Tschöp, MH. "Fibroblast growth factor 21 mediates specific glucagon actions." Diabetes 62, no. 5 (May 2013): 1453-1463. Full Text
- Begg, DP, Mul, JD, Liu, M, Reedy, BM, D'Alessio, DA, Seeley, RJ, and Woods, SC. "Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats." Endocrinology 154, no. 3 (March 2013): 1047-1054. Full Text
- Cummings, BP, Bremer, AA, Kieffer, TJ, D'Alessio, D, and Havel, PJ. "Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques." The Journal of Endocrinology 216, no. 2 (February 2013): 207-215. Full Text
- Jessen, L, Aulinger, BA, Hassel, JL, Roy, KJ, Smith, EP, Greer, TM, Woods, SC, Seeley, RJ, and D'Alessio, DA. "Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4." Endocrinology 153, no. 12 (December 2012): 5735-5745. Full Text
- Salehi, M, Aulinger, B, and D'Alessio, DA. "Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test." Diabetes 61, no. 11 (November 2012): 2728-2733. Full Text
- Chambers, AP, Wilson-Perez, HE, McGrath, S, Grayson, BE, Ryan, KK, D'Alessio, DA, Woods, SC, Sandoval, DA, and Seeley, RJ. "Effect of vertical sleeve gastrectomy on food selection and satiation in rats." American Journal of Physiology. Endocrinology and Metabolism 303, no. 8 (October 2012): E1076-E1084. Full Text
- Tong, J, D'Alessio, D, Ramisch, J, Davis, HW, Stambrook, E, Tschöp, MH, and Bidlingmaier, M. "Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans." The Journal of clinical endocrinology and metabolism 97, no. 9 (September 2012): 3366-3374. Full Text
- Kirk, S, Brehm, B, Saelens, BE, Woo, JG, Kissel, E, D'Alessio, D, Bolling, C, and Daniels, SR. "Role of carbohydrate modification in weight management among obese children: a randomized clinical trial." The Journal of Pediatrics 161, no. 2 (August 2012): 320-7.e1. Full Text
- DeVries, JH, Bain, SC, Rodbard, HW, Seufert, J, D'Alessio, D, Thomsen, AB, Zychma, M, Rosenstock, J, and Liraglutide-Detemir Study Group, . "Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets." Diabetes care 35, no. 7 (July 2012): 1446-1454. Full Text
- Liu, M, Shen, L, Begg, DP, D'alessio, DA, and Woods, SC. "Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats." Journal of neuroscience methods 209, no. 1 (July 2012): 106-112. Full Text
- Mul, JD, Begg, DP, Alsters, SIM, van Haaften, G, Duran, KJ, D'Alessio, DA, le Roux, CW, Woods, SC, Sandoval, DA, Blakemore, AIF, Cuppen, E, van Haelst, MM, and Seeley, RJ. "Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats." American journal of physiology. Endocrinology and metabolism 303, no. 1 (July 2012): E103-E110. Full Text
- Elder, DA, Herbers, PM, Weis, T, Standiford, D, Woo, JG, and D'Alessio, DA. "β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus." The Journal of Pediatrics 160, no. 6 (June 2012): 904-910. Full Text
- Elder, DA, Herbers, PM, Weis, T, Standiford, D, Woo, JG, and D'Alessio, DA. "beta-Cell Dysfunction in Adolescents and Adults with Newly Diagnosed Type 2 Diabetes Mellitus." JOURNAL OF PEDIATRICS 160, no. 6 (June 2012): 904-910. Full Text Link to Item
- Lu, WJ, Yang, Q, Yang, L, Lee, D, D'Alessio, D, and Tso, P. "Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP." Lipids 47, no. 6 (June 2012): 571-580. Full Text
- Rebholz, SL, Jones, T, Burke, KT, Jaeschke, A, Tso, P, D'Alessio, DA, and Woollett, LA. "Multiparity leads to obesity and inflammation in mothers and obesity in male offspring." American journal of physiology. Endocrinology and metabolism 302, no. 4 (February 2012): E449-E457. Full Text
- Sandoval, D, Barrera, JG, Stefater, MA, Sisley, S, Woods, SC, D'Alessio, DD, and Seeley, RJ. "The anorectic effect of GLP-1 in rats is nutrient dependent." PloS one 7, no. 12 (January 2012): e51870-. Full Text
- Chambers, AP, Stefater, MA, Wilson-Perez, HE, Jessen, L, Sisley, S, Ryan, KK, Gaitonde, S, Sorrell, JE, Toure, M, Berger, J, D'Alessio, DA, Sandoval, DA, Seeley, RJ, and Woods, SC. "Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats." Physiology & Behavior 105, no. 1 (November 2011): 120-123. Full Text
- Summer, SS, Brehm, BJ, Benoit, SC, and D'Alessio, DA. "Adiponectin changes in relation to the macronutrient composition of a weight-loss diet." Obesity (Silver Spring, Md.) 19, no. 11 (November 2011): 2198-2204. Full Text
- Carrel, G, Egli, L, Tran, C, Schneiter, P, Giusti, V, D'Alessio, D, and Tappy, L. "Contributions of fat and protein to the incretin effect of a mixed meal." The American journal of clinical nutrition 94, no. 4 (October 2011): 997-1003. Full Text
- D'Alessio, D. "The role of dysregulated glucagon secretion in type 2 diabetes." Diabetes, Obesity & Metabolism 13 Suppl 1 (October 2011): 126-132. (Review) Full Text
- Chambers, AP, Jessen, L, Ryan, KK, Sisley, S, Wilson-Pérez, HE, Stefater, MA, Gaitonde, SG, Sorrell, JE, Toure, M, Berger, J, D'Alessio, DA, Woods, SC, Seeley, RJ, and Sandoval, DA. "Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats." Gastroenterology 141, no. 3 (September 2011): 950-958. Full Text
- Salehi, M, Prigeon, RL, and D'Alessio, DA. "Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans." Diabetes 60, no. 9 (September 2011): 2308-2314. Full Text
- D'Alessio, DA. "What if gut hormones aren't really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract." Endocrinology 152, no. 8 (August 2011): 2925-2926. Full Text
- Lo, C-M, Obici, S, Dong, HH, Haas, M, Lou, D, Kim, DH, Liu, M, D'Alessio, D, Woods, SC, and Tso, P. "Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice." Diabetes 60, no. 7 (July 2011): 2000-2007. Full Text
- Barrera, JG, Sandoval, DA, D'Alessio, DA, and Seeley, RJ. "GLP-1 and energy balance: an integrated model of short-term and long-term control." Nature reviews. Endocrinology 7, no. 9 (June 7, 2011): 507-516. (Review) Full Text
- Brehm, BJ, Gates, DM, Singler, M, Succop, PA, and D'Alessio, DA. "Environmental changes to control obesity: a randomized controlled trial in manufacturing companies." American journal of health promotion : AJHP 25, no. 5 (May 2011): 334-340. Full Text
- Clegg, DJ, Gotoh, K, Kemp, C, Wortman, MD, Benoit, SC, Brown, LM, D'Alessio, D, Tso, P, Seeley, RJ, and Woods, SC. "Consumption of a high-fat diet induces central insulin resistance independent of adiposity." Physiology & Behavior 103, no. 1 (April 2011): 10-16. Full Text
- Tong, J, Mannea, E, Aimé, P, Pfluger, PT, Yi, C-X, Castaneda, TR, Davis, HW, Ren, X, Pixley, S, Benoit, S, Julliard, K, Woods, SC, Horvath, TL, Sleeman, MM, D'Alessio, D, Obici, S, Frank, R, and Tschöp, MH. "Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans." The Journal of Neuroscience 31, no. 15 (April 2011): 5841-5846. Full Text
- Barrera, JG, Jones, KR, Herman, JP, D'Alessio, DA, Woods, SC, and Seeley, RJ. "Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 10 (March 2011): 3904-3913. Full Text
- Kindel, TL, Martins, PJF, Yoder, SM, Jandacek, RJ, Seeley, RJ, D'Alessio, DA, Obici, S, and Tso, P. "Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents." Obesity (Silver Spring, Md.) 19, no. 2 (February 2011): 380-387. Full Text
- Klimek, AM, Soukhatcheva, G, Thompson, DM, Warnock, GL, Salehi, M, Rilo, H, DAlessio, D, Meneilly, GS, Panagiotopoulos, C, and Verchere, CB. "Erratum: Impaired proinsulin processing is a characteristic of transplanted islets (American Journal of Transplantation (2009) 9 (2119-2125) (doi: 10.1111/j.1600-6143.2009.02740.x))." American Journal of Transplantation 11, no. 2 (February 1, 2011): 414-null. Full Text
- Tong, J, and D'Alessio, D. "Eating disorders and gastrointestinal peptides." Current opinion in endocrinology, diabetes, and obesity 18, no. 1 (February 2011): 42-49. (Review) Full Text
- Zhang, R, Jankord, R, Flak, JN, Solomon, MB, D'Alessio, DA, and Herman, JP. "Role of glucocorticoids in tuning hindbrain stress integration." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 44 (November 2010): 14907-14914. Full Text
- Kohli, R, Kirby, M, Setchell, KDR, Jha, P, Klustaitis, K, Woollett, LA, Pfluger, PT, Balistreri, WF, Tso, P, Jandacek, RJ, Woods, SC, Heubi, JE, Tschoep, MH, D'Alessio, DA, Shroyer, NF, and Seeley, RJ. "Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities." American journal of physiology. Gastrointestinal and liver physiology 299, no. 3 (September 2010): G652-G660. Full Text
- Tong, J, Prigeon, RL, Davis, HW, Bidlingmaier, M, Kahn, SE, Cummings, DE, Tschöp, MH, and D'Alessio, D. "Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans." Diabetes 59, no. 9 (September 2010): 2145-2151. Full Text Open Access Copy
- Elder, DA, Woo, JG, and D'Alessio, DA. "Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes." Pediatric Diabetes 11, no. 5 (August 2010): 314-321. Full Text
- Abumrad, N, Meguid, MM, Klein, S, Pichard, C, D'Alessio, D, and Tappy, L. "Editorial introductions." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (July 1, 2010). Full Text
- D'Alessio, DA. "Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target?." Diabetes 59, no. 7 (July 2010): 1572-1574. Full Text
- Lê, K-A, D'Alessio, DA, and Tappy, L. "Metabolic effects of excess energy intake: does food composition matter?." Current Opinion in Clinical Nutrition and Metabolic Care 13, no. 4 (July 2010): 429-431. Full Text
- Diab, DL, and D'Alessio, DA. "The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus." Current diabetes reports 10, no. 3 (June 2010): 192-198. (Review) Full Text
- Kindel, TL, Yoder, SM, D'Alessio, DA, and Tso, P. "The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats." Obesity surgery 20, no. 6 (June 2010): 768-775. Full Text
- Salehi, M, Aulinger, B, Prigeon, RL, and D'Alessio, DA. "Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes." Diabetes 59, no. 6 (June 2010): 1330-1337. Full Text
- Pérez-Tilve, D, González-Matías, L, Aulinger, BA, Alvarez-Crespo, M, Gil-Lozano, M, Alvarez, E, Andrade-Olivie, AM, Tschöp, MH, D'Alessio, DA, and Mallo, F. "Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system." American Journal of Physiology. Endocrinology and Metabolism 298, no. 5 (May 2010): E1088-E1096. Full Text
- Tong, J, Tschöp, MH, Aulinger, BA, Davis, HW, Yang, Q, Liu, J, Gaylinn, BD, Thorner, MO, D'Alessio, D, and Tso, P. "The intestinal lymph fistula model--a novel approach to study ghrelin secretion." American Journal of Physiology. Gastrointestinal and Liver Physiology 298, no. 3 (March 2010): G474-G480. Full Text
- Vahl, TP, Drazen, DL, Seeley, RJ, D'Alessio, DA, and Woods, SC. "Meal-anticipatory glucagon-like peptide-1 secretion in rats." Endocrinology 151, no. 2 (February 2010): 569-575. Full Text
- Barrera, JG, D'Alessio, DA, Drucker, DJ, Woods, SC, and Seeley, RJ. "Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats." Diabetes 58, no. 12 (December 2009): 2820-2827. Full Text
- Falciglia, M, Freyberg, RW, Almenoff, PL, D'Alessio, DA, and Render, ML. "Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis." Critical Care Medicine 37, no. 12 (December 2009): 3001-3009. Full Text
- Jessen, L, and D'Alessio, D. "The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes." Gastroenterology 137, no. 6 (December 2009): 1891-1894. Full Text
- Kindel, TL, Yoder, SM, Seeley, RJ, D'Alessio, DA, and Tso, P. "Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 13, no. 10 (October 2009): 1762-1772. Full Text
- Urbina, EM, Khoury, P, Martin, LJ, D'Alessio, D, and Dolan, LM. "Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults." International journal of obesity (2005) 33, no. 10 (October 2009): 1118-1125. Full Text
- Klimek, AM, Soukhatcheva, G, Thompson, DM, Warnock, GL, Salehi, M, Rilo, H, D'Alessio, D, Meneilly, GS, Panagiotopoulos, C, and Verchere, CB. "Impaired proinsulin processing is a characteristic of transplanted islets." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 9, no. 9 (September 2009): 2119-2125. Full Text
- Zhang, R, Packard, BA, Tauchi, M, D'Alessio, DA, and Herman, JP. "Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 14, (5913-5918) 10.1073/pnas.0808716106)." Proceedings of the National Academy of Sciences of the United States of America 106, no. 32 (August 11, 2009): 13636-null. Full Text
- Zhang, R, Packard, BA, Tauchi, M, D'Alessio, DA, and Herman, JP. "Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress (vol 106, pg 5913, 2009)." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, no. 32 (August 11, 2009): 13636-13636. Full Text Link to Item
- Cota, D, Sandoval, DA, Olivieri, M, Prodi, E, D'Alessio, DA, Woods, SC, Seeley, RJ, and Obici, S. "Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism." Obesity (Silver Spring, Md.) 17, no. 8 (August 2009): 1641-1645. Full Text
- Abumrad, N, Grimble, RF, Pichard, C, Meguid, MM, D'Alessio, D, and Tappy, L. "Editorial introductions." Current Opinion in Clinical Nutrition and Metabolic Care 12, no. 4 (July 1, 2009). Full Text
- Elder, DA, and D'Alessio, DA. "beta-Cell Function in Adolescents Presenting with Type 2 Diabetes Is Impaired and Comparable to Newly Diagnosed Diabetic Adults." DIABETES 58 (June 2009): A463-A463. Link to Item
- Jessen, L, Aulinger, BA, Greer, T, Seeley, RJ, Woods, SC, and D'Alessio, DA. "Effects of Glucagon-Like Peptide-1 and Exendin-4 on Food Intake with and without DPP-4 Inhibition." DIABETES 58 (June 2009): A395-A395. Link to Item
- Kim, D-H, D'Alessio, DA, Woods, SC, and Seeley, RJ. "The effects of GLP-1 infusion in the hepatic portal region on food intake." Regulatory peptides 155, no. 1-3 (June 2009): 110-114. Full Text
- Perez-Tilve, D, Gonzalez-Matias, L, Aulinger, BA, Alvarez-Crespo, M, Gil-Lozano, M, Tschoep, MH, D'Alessio, DA, and Mallo, F. "Exendin-4 Increases Blood Glucose Levels Acutely in Rats by Activation of the Sympathetic Nervous System." DIABETES 58 (June 2009): A135-A136. Link to Item
- Salehi, M, Alexander, JW, Fischer, DR, Tong, J, and D'Alessio, DA. "Insulin Secretion Mediated by GLP-1 Action Is Enhanced Following Roux-en-Y Gastric Bypass Surgery." DIABETES 58 (June 2009): A39-A40. Link to Item
- Zhang, R, Packard, BA, Tauchi, M, D'Alessio, DA, and Herman, JP. "Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress." Proceedings of the National Academy of Sciences of the United States of America 106, no. 14 (April 2009): 5913-5918. Full Text
- Brehm, BJ, Lattin, BL, Summer, SS, Boback, JA, Gilchrist, GM, Jandacek, RJ, and D'Alessio, DA. "One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes." Diabetes Care 32, no. 2 (February 2009): 215-220. Full Text
- D'Alessio, DA, Denney, AM, Hermiller, LM, Prigeon, RL, Martin, JM, Tharp, WG, Saylan, ML, He, Y, Dunning, BE, Foley, JE, and Pratley, RE. "Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes." The Journal of Clinical Endocrinology and Metabolism 94, no. 1 (January 2009): 81-88. Full Text
- Shertzer, HG, Schneider, SN, Kendig, EL, Clegg, DJ, D'Alessio, DA, Johansson, E, and Genter, MB. "Tetrahydroindenoindole inhibits the progression of diabetes in mice." Chemico-biological interactions 177, no. 1 (January 2009): 71-80. Full Text
- Salehi, M, Vahl, TP, and D'Alessio, DA. "Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion." The Journal of clinical endocrinology and metabolism 93, no. 12 (December 2008): 4909-4916. Full Text
- Tauchi, M, Zhang, R, D'Alessio, DA, Stern, JE, and Herman, JP. "Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei." Journal of chemical neuroanatomy 36, no. 3-4 (December 2008): 144-149. Full Text
- Woods, SC, and D'Alessio, DA. "Central control of body weight and appetite." Journal of Clinical Endocrinology and Metabolism 93, no. 11 SUPPL. 1 (November 1, 2008). (Review) Full Text
- Woods, SC, and D'Alessio, DA. "Central control of body weight and appetite." The Journal of Clinical Endocrinology and Metabolism 93, no. 11 Suppl 1 (November 2008): S37-S50. (Review) Full Text
- Brehm, BJ, and D'Alessio, DA. "Benefits of high-protein weight loss diets: enough evidence for practice?." Current opinion in endocrinology, diabetes, and obesity 15, no. 5 (October 2008): 416-421. (Review) Full Text
- Perez-Tilve, D, D'Alessio, DA, and Tschöp, MH. "A sweet spot for the bariatric surgeon." Cell metabolism 8, no. 3 (September 2008): 177-179. Full Text
- D'Alessio, DA. "Citation for the 2008 Ernst Oppenheimer Award of The Endocrine Society to Dr. Randy J. Seeley." ENDOCRINE REVIEWS 29, no. 5 (August 2008): 636-637. Link to Item
- D'Alessio, DA. "Randy J Seeley." JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 93, no. 8 (August 2008): 3235-3236. Link to Item
- D'Alessio, DA. "Dr. Randy J. Seeley." ENDOCRINOLOGY 149, no. 8 (August 2008): 4234-4235. Link to Item
- Elder, DA, D'Alessio, DA, Eyal, O, Mueller, R, Smith, FO, Kansra, AR, and Rose, SR. "Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion." Pediatric Blood & Cancer 51, no. 2 (August 2008): 256-260. Full Text
- Sandoval, DA, Bagnol, D, Woods, SC, D'Alessio, DA, and Seeley, RJ. "Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake." Diabetes 57, no. 8 (August 2008): 2046-2054. Full Text
- Strawn, JR, D'Alessio, DA, Keck, PE, and Seeley, RJ. "Failure of glucagon-like peptide-1 to induce panic attacks or anxiety in patients with panic disorder." Journal of psychiatric research 42, no. 9 (July 2008): 787-789. Full Text
- Lu, WJ, Yang, Q, Sun, W, Woods, SC, D'Alessio, D, and Tso, P. "Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose." American Journal of Physiology. Gastrointestinal and Liver Physiology 294, no. 5 (May 2008): G1130-G1138. Full Text
- Salehi, M, Aulinger, BA, and D'Alessio, DA. "Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins." Endocrine Reviews 29, no. 3 (May 2008): 367-379. (Review) Full Text
- Gray, DL, O'Brien, KD, D'Alessio, DA, Brehm, BJ, and Deeg, MA. "Plasma glycosylphosphatidylinositol-specific phospholipase D predicts the change in insulin sensitivity in response to a low-fat but not a low-carbohydrate diet in obese women." Metabolism: Clinical and Experimental 57, no. 4 (April 2008): 473-478. Full Text
- Reed, JA, Benoit, SC, Pfluger, PT, Tschöp, MH, D'Alessio, DA, and Seeley, RJ. "Mice with chronically increased circulating ghrelin develop age-related glucose intolerance." American journal of physiology. Endocrinology and metabolism 294, no. 4 (April 2008): E752-E760. Full Text
- Tauchi, M, Zhang, R, D'Alessio, DA, Seeley, RJ, and Herman, JP. "Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress." Experimental Neurology 210, no. 2 (April 2008): 458-466. Full Text
- Brehm, BJ, and D'Alessio, DA. "Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff." Nature clinical practice. Endocrinology & metabolism 4, no. 3 (March 2008): 140-146. (Review) Full Text
- Kemp, CJ, D'Alessio, DA, Scott, RO, Kelm, GR, Meller, ST, Barrera, JG, Seeley, RJ, Clegg, DJ, and Benoit, SC. "Voluntary consumption of ethyl oleate reduces food intake and body weight in rats." Physiology & Behavior 93, no. 4-5 (March 2008): 912-918. Full Text
- Shertzer, HG, Schneider, SN, Kendig, EL, Clegg, DJ, D'Alessio, DA, and Genter, MB. "Acetaminophen normalizes glucose homeostasis in mouse models for diabetes." Biochemical pharmacology 75, no. 6 (March 2008): 1402-1410. Full Text
- Rodieux, F, Giusti, V, D'Alessio, DA, Suter, M, and Tappy, L. "Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release." Obesity (Silver Spring, Md.) 16, no. 2 (February 2008): 298-305. Full Text
- Guerdjikova, AI, McElroy, SL, Kotwal, R, Welge, JA, Nelson, E, Lake, K, Alessio, DD, Keck, PE, and Hudson, JI. "High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial." Human psychopharmacology 23, no. 1 (January 2008): 1-11. Full Text
- D'Alessio, D, Lu, W, Sun, W, Zheng, S, Yang, Q, Seeley, R, Woods, SC, and Tso, P. "Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system." American Journal of Physiology Regulatory, Integrative and Comparative Physiology 293, no. 6 (December 2007): R2163-R2169. Full Text
- Elder, DA, Wooldridge, JL, Dolan, LM, and D'Alessio, DA. "Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes." The Journal of Pediatrics 151, no. 6 (December 2007): 653-658. Full Text
- Lu, WJ, Yang, Q, Sun, W, Woods, SC, D'Alessio, D, and Tso, P. "The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate." American Journal of Physiology. Gastrointestinal and Liver Physiology 293, no. 5 (November 2007): G963-G971. Full Text
- Brehm, B, Gates, D, Singler, M, Poeppelman, A, Succop, P, and D'Alessio, D. "Prevalence of obesity and cardiovascular risk factors among manufacturing company employees in Kentucky." AAOHN journal : official journal of the American Association of Occupational Health Nurses 55, no. 10 (October 2007): 397-406.
- Vahl, TP, Tauchi, M, Durler, TS, Elfers, EE, Fernandes, TM, Bitner, RD, Ellis, KS, Woods, SC, Seeley, RJ, Herman, JP, and D'Alessio, DA. "Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats." Endocrinology 148, no. 10 (October 2007): 4965-4973. Full Text
- Wiedmer, P, Nogueiras, R, Broglio, F, D'Alessio, D, and Tschöp, MH. "Ghrelin, obesity and diabetes." Nature Clinical Practice. Endocrinology & Metabolism 3, no. 10 (October 2007): 705-712. (Review) Full Text
- Abumrad, N, Doria, A, Pichard, C, Meguid, M, D'Alessio, D, and Tappy, L. "Editorial introductions." Current Opinion in Clinical Nutrition and Metabolic Care 10, no. 4 (July 1, 2007). Full Text
- Lê, K-A, Tappy, L, and D'Alessio, DA. "Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?." Current opinion in clinical nutrition and metabolic care 10, no. 4 (July 2007): 494-497. (Review) Full Text
- Urbina, EM, Bean, JA, Daniels, SR, D'Alessio, D, and Dolan, LM. "Overweight and hyperinsulinemia provide individual contributions to compromises in brachial artery distensibility in healthy adolescents and young adults." Journal of the American Society of Hypertension 1, no. 3 (May 1, 2007): 200-207. Full Text
- Aulinger, B, and D'Alessio, D. "Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic." Current Opinion in Endocrinology, Diabetes, and Obesity 14, no. 1 (February 2007): 68-73. (Review) Full Text
- Pfluger, PT, Kampe, J, Castaneda, TR, Vahl, T, D'Alessio, DA, Kruthaupt, T, Benoit, SC, Cuntz, U, Rochlitz, HJ, Moehlig, M, Pfeiffer, AF, Koebnick, C, Weickert, MO, Otto, B, Spranger, J, and Tschöp, MH. "Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36." The Journal of clinical endocrinology and metabolism 92, no. 2 (February 2007): 583-588. Full Text
- McElroy, SL, Kotwal, R, Guerdjikova, AI, Welge, JA, Nelson, EB, Lake, KA, D'Alessio, DA, Keck, PE, and Hudson, JI. "Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial." The Journal of Clinical Psychiatry 67, no. 12 (December 2006): 1897-1906.
- Watts, NB, and D'Alessio, DA. "Type 2 diabetes, thiazolidinediones: bad to the bone?." The Journal of clinical endocrinology and metabolism 91, no. 9 (September 2006): 3276-3278. Full Text
- Abumrad, N, Lange, A, Pichard, C, Meguid, M, D'Alessio, D, and Tappy, L. "Editorial introductions." Current Opinion in Clinical Nutrition and Metabolic Care 9, no. 4 (July 1, 2006). Full Text
- Tappy, L, and D'Alessio, D. "Obesity and insulin resistance: is it due to body fat, energy balance, or gut factors?." Current opinion in clinical nutrition and metabolic care 9, no. 4 (July 2006): 455-457. Full Text
- Um, SH, D'Alessio, D, and Thomas, G. "Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1." Cell Metabolism 3, no. 6 (June 2006): 393-402. (Review) Full Text
- Salehi, M, and D'Alessio, DA. "New therapies for type 2 diabetes based on glucagon-like peptide 1." Cleveland Clinic journal of medicine 73, no. 4 (April 2006): 382-389. (Review)
- Drazen, DL, Vahl, TP, D'Alessio, DA, Seeley, RJ, and Woods, SC. "Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status." Endocrinology 147, no. 1 (January 2006): 23-30. Full Text
- Elder, DA, Prigeon, RL, Wadwa, RP, Dolan, LM, and D'Alessio, DA. "Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults." The Journal of clinical endocrinology and metabolism 91, no. 1 (January 2006): 185-191. Full Text
- Gotoh, K, Liu, M, Benoit, SC, Clegg, DJ, Davidson, WS, D'Alessio, D, Seeley, RJ, Tso, P, and Woods, SC. "Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 290, no. 1 (January 2006): R202-R207. Full Text
- Watts, NB, and D'Alessio, DA. "Editorial: Type 2 diabetes, thiazolidinediones: Bad to the bone?." Journal of Clinical Endocrinology and Metabolism 91, no. 9 (January 1, 2006): 3276-3278. Full Text
- D'Alessio, DA, Sandoval, DA, and Seeley, RJ. "New ways in which GLP-1 can regulate glucose homeostasis." The Journal of Clinical Investigation 115, no. 12 (December 2005): 3406-3408. Full Text
- Ahmad, SA, Lowy, AM, Wray, CJ, D'Alessio, D, Choe, KA, James, LE, Gelrud, A, Matthews, JB, and Rilo, HLR. "Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis." Journal of the American College of Surgeons 201, no. 5 (November 2005): 680-687. Full Text
- Vahl, TP, Ulrich-Lai, YM, Ostrander, MM, Dolgas, CM, Elfers, EE, Seeley, RJ, D'Alessio, DA, and Herman, JP. "Comparative analysis of ACTH and corticosterone sampling methods in rats." American Journal of Physiology. Endocrinology and Metabolism 289, no. 5 (November 2005): E823-E828. Full Text
- D'Alessio, DA, and Vahl, TP. "Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches." Current Diabetes Reports 5, no. 5 (October 2005): 346-352. (Review) Full Text
- Proulx, K, Cota, D, Castañeda, TR, Tschöp, MH, D'Alessio, DA, Tso, P, Woods, SC, and Seeley, RJ. "Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 289, no. 3 (September 2005): R729-R737. Full Text
- D'Alessio, DA, Lê, K-A, and Tappy, L. "Type 2 diabetes and insulin resistance: an hepatocentric phenomenon?." Current Opinion in Clinical Nutrition and Metabolic Care 8, no. 4 (July 2005): 428-430. Full Text
- Dolan, LM, Bean, J, D'Alessio, D, Cohen, RM, Morrison, JA, Goodman, E, and Daniels, SR. "Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents." The Journal of pediatrics 146, no. 6 (June 2005): 751-758. Full Text
- Qin, X, Shen, H, Liu, M, Yang, Q, Zheng, S, Sabo, M, D'Alessio, DA, and Tso, P. "GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats." American Journal of Physiology. Gastrointestinal and Liver Physiology 288, no. 5 (May 2005): G943-G949. Full Text
- O'Brien, KD, Brehm, BJ, Seeley, RJ, Bean, J, Wener, MH, Daniels, S, and D'Alessio, DA. "Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects." The Journal of clinical endocrinology and metabolism 90, no. 4 (April 2005): 2244-2249. Full Text
- Brehm, BJ, Spang, SE, Lattin, BL, Seeley, RJ, Daniels, SR, and D'Alessio, DA. "The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets." The Journal of Clinical Endocrinology and Metabolism 90, no. 3 (March 2005): 1475-1482. Full Text
- Strader, AD, Vahl, TP, Jandacek, RJ, Woods, SC, D'Alessio, DA, and Seeley, RJ. "Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats." American Journal of Physiology. Endocrinology and Metabolism 288, no. 2 (February 2005): E447-E453. Full Text
- Lachey, JL, D'Alessio, DA, Rinaman, L, Elmquist, JK, Drucker, DJ, and Seeley, RJ. "The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice." Endocrinology 146, no. 1 (January 2005): 458-462. Full Text
- Wray, CJ, Ahmad, SA, Lowy, AM, D'Alessio, DA, Gelrud, A, Choe, KA, Soldano, DA, Matthews, JB, and Rodriguez-Rilo, HL. "Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions." Pancreatology : official journal of the International Association of Pancreatology (IAP) .. [et al.] 5, no. 6 (January 2005): 562-569. Full Text
- Woods, SC, D'Alessio, DA, Tso, P, Rushing, PA, Clegg, DJ, Benoit, SC, Gotoh, K, Liu, M, and Seeley, RJ. "Consumption of a high-fat diet alters the homeostatic regulation of energy balance." Physiology & behavior 83, no. 4 (December 2004): 573-578. (Review) Full Text
- D'Alessio, D, Vahl, T, and Prigeon, R. "Effects of glucagon-like peptide 1 on the hepatic glucose metabolism." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 36, no. 11-12 (November 2004): 837-841. (Review) Full Text
- Liu, M, Shen, L, Liu, Y, Woods, SC, Seeley, RJ, D'Alessio, D, and Tso, P. "Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus." American journal of physiology. Endocrinology and metabolism 287, no. 2 (August 2004): E366-E370. Full Text
- Abumrad, N, Clément, K, Meguid, M, D'Alessio, D, and Tappy, L. "Editorial introductions." Current Opinion in Clinical Nutrition and Metabolic Care 7, no. 4 (July 1, 2004). Full Text
- Tappy, L, and D'Alessio, D. "How are we going to understand (dys)regulation of glucose metabolism?." Current opinion in clinical nutrition and metabolic care 7, no. 4 (July 2004): 467-469. Full Text
- D'Alessio, DA, and Vahl, TP. "Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes." American journal of physiology. Endocrinology and metabolism 286, no. 6 (June 2004): E882-E890. (Review) Full Text
- Seeley, RJ, D'Alessio, DA, and Woods, SC. "Fat hormones pull their weight in the CNS." Nature medicine 10, no. 5 (May 2004): 454-455. Full Text
- Vahl, TP, and D'Alessio, DA. "Gut peptides in the treatment of diabetes mellitus." Expert opinion on investigational drugs 13, no. 3 (March 2004): 177-188. (Review) Full Text
- Ehlers, MR, Klaff, LJ, D'Alessio, DA, Brazg, R, Kay, HD, Harley, RE, Mathisen, AL, and Schneider, R. "Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 35, no. 10 (October 2003): 611-616. Full Text
- Ensinck, JW, Laschansky, EC, Vogel, RE, and D'Alessio, DA. "Effect of ingested nutrients on the release of thrittene into the human circulation." The Journal of Clinical Endocrinology and Metabolism 88, no. 10 (October 2003): 4798-4804. Full Text
- Prigeon, RL, Quddusi, S, Paty, B, and D'Alessio, DA. "Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect." American journal of physiology. Endocrinology and metabolism 285, no. 4 (October 2003): E701-E707. Full Text
- Henchoz, E, D'Alessio, DA, Gillet, M, Halkic, N, Matzinger, O, Goy, J-J, Chioléro, R, Tappy, L, and Schneiter, P. "Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients." Transplantation 76, no. 6 (September 2003): 923-929. Full Text
- Clegg, DJ, Benoit, SC, Air, EL, Jackman, A, Tso, P, D'Alessio, D, Woods, SC, and Seeley, RJ. "Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII." Endocrinology 144, no. 7 (July 2003): 2941-2946. Full Text
- Kinzig, KP, D'Alessio, DA, Herman, JP, Sakai, RR, Vahl, TP, Figueiredo, HF, Murphy, EK, and Seeley, RJ. "CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, no. 15 (July 2003): 6163-6170.
- Vahl, T, and D'Alessio, D. "Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism." Current Opinion in Clinical Nutrition and Metabolic Care 6, no. 4 (July 2003): 461-468. (Review) Full Text
- Wortman, MD, Clegg, DJ, D'Alessio, D, Woods, SC, and Seeley, RJ. "C75 inhibits food intake by increasing CNS glucose metabolism." Nature Medicine 9, no. 5 (May 2003): 483-485. (Letter) Full Text
- Brehm, BJ, Seeley, RJ, Daniels, SR, and D'Alessio, DA. "A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women." The Journal of Clinical Endocrinology and Metabolism 88, no. 4 (April 2003): 1617-1623. Full Text
- Vahl, TP, Paty, BW, Fuller, BD, Prigeon, RL, and D'Alessio, DA. "Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans." The Journal of Clinical Endocrinology and Metabolism 88, no. 4 (April 2003): 1772-1779. Full Text
- Woods, SC, Seeley, RJ, Rushing, PA, D'Alessio, D, and Tso, P. "A controlled high-fat diet induces an obese syndrome in rats." The Journal of Nutrition 133, no. 4 (April 2003): 1081-1087. Full Text
- Quddusi, S, Vahl, TP, Hanson, K, Prigeon, RL, and D'Alessio, DA. "Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans." Diabetes Care 26, no. 3 (March 2003): 791-798. Full Text
- Kinzig, KP, D'Alessio, DA, and Seeley, RJ. "The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22, no. 23 (December 2002): 10470-10476. Full Text
- Ensinck, JW, Baskin, DG, Vahl, TP, Vogel, RE, Laschansky, EC, Francis, BH, Hoffman, RC, Krakover, JD, Stamm, MR, Low, MJ, Rubinstein, M, Otero-Corchon, V, and D'Alessio, DA. "Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation." Endocrinology 143, no. 7 (July 2002): 2599-2609. Full Text
- Ensinck, JW, Baskin, DG, Vahl, TP, Vogel, RE, Laschansky, EC, Francis, BH, Hoffman, RC, Krakover, JD, Stamm, MR, Low, MJ, Rubinstein, M, Otero-Corchon, V, and D'Alessio, DA. "Thrittene, Homologous with Somatostatin-28(1-13), Is a Novel Peptide in Mammalian Gut and Circulation." Endocrinology 143, no. 7 (July 2002): 2599-2609.
- Greenbaum, CJ, Prigeon, RL, and D'Alessio, DA. "Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose." Diabetes 51, no. 4 (April 2002): 951-957. Full Text
- Tamashiro, KLK, Wakayama, T, Akutsu, H, Yamazaki, Y, Lachey, JL, Wortman, MD, Seeley, RJ, D'Alessio, DA, Woods, SC, Yanagimachi, R, and Sakai, RR. "Cloned mice have an obese phenotype not transmitted to their offspring." Nature Medicine 8, no. 3 (March 2002): 262-267. Full Text
- Rushing, PA, Hagan, MM, Seeley, RJ, Lutz, TA, D'Alessio, DA, Air, EL, and Woods, SC. "Inhibition of central amylin signaling increases food intake and body adiposity in rats." Endocrinology 142, no. 11 (November 2001): 5035-null. Full Text
- D'Alessio, DA, Kieffer, TJ, Taborsky, GJ, and Havel, PJ. "Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques." The Journal of Clinical Endocrinology and Metabolism 86, no. 3 (March 2001): 1253-1259. Full Text
- Verchere, CB, D'Alessio, DA, Prigeon, RL, Hull, RL, and Kahn, SE. "The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells." Diabetes 49, no. 9 (September 2000): 1477-1484. Full Text
- Seeley, RJ, Blake, K, Rushing, PA, Benoit, S, Eng, J, Woods, SC, and D'Alessio, D. "The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 20, no. 4 (February 2000): 1616-1621. Full Text
- Seeley, RJ, Woods, SC, and D'Alessio, D. "Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function." Endocrinology 141, no. 2 (February 2000): 473-475. (Review) Full Text
- Greenbaum, CJ, Prigeon, RL, and D'Alessio, DA. "Abnormal incretin effect in subjects with "silent" type I diabetes." Journal of Investigative Medicine 47, no. 2 (January 1, 1999).
- Paty, BW, Finegood, D, D'Alessio, DA, and Meneilly, GS. "Glucose metabolism in elderly patients with type 2 diabetes mellitus." Journal of Investigative Medicine 47, no. 2 (January 1, 1999).
- Hirsch, IB, D'Alessio, D, Eng, L, Davis, C, Lernmark, A, and Chait, A. "Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro." Diabetes Research and Clinical Practice 41, no. 3 (September 1998): 197-202. Full Text
- Thiele, TE, Seeley, RJ, D'Alessio, D, Eng, J, Bernstein, IL, Woods, SC, and van Dijk, G. "Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem." Brain Research 801, no. 1-2 (August 1998): 164-170. Full Text
- Owen, OE, Smalley, KJ, D'Alessio, DA, Mozzoli, MA, and Dawson, EK. "Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis." The American journal of clinical nutrition 68, no. 1 (July 1998): 12-34. Full Text
- Ensinck, JW, Vogel, RE, Laschansky, EC, Koerker, DJ, Prigeon, RL, Kahn, SE, and D'Alessio, DA. "Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons." The Journal of Clinical Investigation 100, no. 9 (November 1997): 2295-2302. Full Text
- D'Alessio, D. "Peptide hormone regulation of islet cells." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 29, no. 6 (June 1997): 297-300. (Review) Full Text
- Verchere, CB, D'Alessio, DA, Wang, S, Andrikopoulos, S, and Kahn, SE. "Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation." Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 29, no. 6 (June 1997): 311-316. (Review) Full Text
- Verchere, CB, D'Alessio, DA, Palmiter, RD, Weir, GC, Bonner-Weir, S, Baskin, DG, and Kahn, SE. "Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide." Proceedings of the National Academy of Sciences of the United States of America 93, no. 8 (April 1996): 3492-3496. Full Text
- D'Alessio, DA, Vogel, R, Prigeon, R, Laschansky, E, Koerker, D, Eng, J, and Ensinck, JW. "Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons." The Journal of clinical investigation 97, no. 1 (January 1996): 133-138. Full Text
- D'Alessio, DA, Prigeon, RL, and Ensinck, JW. "Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I." Diabetes 44, no. 12 (December 1995): 1433-1437. Full Text
- D'Alessio, DA, Verchere, CB, Kahn, SE, Hoagland, V, Baskin, DG, Palmiter, RD, and Ensinck, JW. "Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse." Diabetes 43, no. 12 (December 1994): 1457-1461. Full Text
- Verchere, CB, D'Alessio, DA, Palmiter, RD, and Kahn, SE. "Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro." Diabetologia 37, no. 7 (July 1994): 725-728. Full Text
- D'Alessio, DA, Kahn, SE, Leusner, CR, and Ensinck, JW. "Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal." The Journal of clinical investigation 93, no. 5 (May 1994): 2263-2266. Full Text
- Baskin, DG, Schwartz, MW, Sipols, AJ, D'Alessio, DA, Goldstein, BJ, and White, MF. "Insulin receptor substrate-1 (IRS-1) expression in rat brain." Endocrinology 134, no. 4 (April 1994): 1952-1955. Full Text
- Kahn, SE, Verchere, CB, D'Alessio, DA, Cook, DL, and Fujimoto, WY. "Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway." Diabetologia 36, no. 6 (June 1993): 570-573. Full Text
- Alessio, DD, Thirlby, R, Laschansky, E, Zebroski, H, and Ensinck, J. "Response of tGLP-1 to nutrients in humans." Digestion 54, no. 6 (January 1, 1993): 377-379. Full Text
- Boswell, T, Richardson, RD, Schwartz, MW, D'Alessio, DA, Woods, SC, Sipols, AJ, Baskin, DG, and Kenagy, GJ. "NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding." Brain research bulletin 32, no. 4 (January 1993): 379-384. Full Text
- Ensinck, JW, and D'Alessio, DA. "The enteroinsular axis revisited. A novel role for an incretin." The New England Journal of Medicine 326, no. 20 (May 1992): 1352-1353. Full Text
- Owen, OE, Mozzoli, MA, Smalley, KJ, Kavle, EC, and D'Alessio, DA. "Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals." The American journal of clinical nutrition 55, no. 3 (March 1992): 630-636. Full Text
- Kahn, SE, Fujimoto, WY, D'Alessio, DA, Ensinck, JW, and Porte, D. "Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell." Hormone and Metabolic Research = Hormon Und Stoffwechselforschung = Hormones Et Metabolisme 23, no. 12 (December 1991): 577-580. Full Text
- Ensinck, JW, Laschansky, EC, Vogel, RE, and D'Alessio, DA. "Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas." Diabetes 40, no. 9 (September 1991): 1163-1169. Full Text
- D'Alessio, DA, and Ensinck, JW. "Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men." Diabetes 39, no. 10 (October 1990): 1198-1202. Full Text
- Kahn, SE, D'Alessio, DA, Schwartz, MW, Fujimoto, WY, Ensinck, JW, Taborsky, GJ, and Porte, D. "Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells." Diabetes 39, no. 5 (May 1990): 634-638. Full Text
- Owen, OE, Smalley, KJ, D'Alessio, DA, Mozzoli, MA, Knerr, AN, Kendrick, ZV, Kavle, EC, Donohoe, M, Tappy, L, and Boden, G. "Resting metabolic rate and body composition of achondroplastic dwarfs." Medicine 69, no. 1 (January 1990): 56-67.
- D'Alessio, DA, Fujimoto, WY, and Ensinck, JW. "Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures." Diabetes 38, no. 12 (December 1989): 1534-1538. Full Text
- D'Alessio, DA, Sieber, C, Beglinger, C, and Ensinck, JW. "A physiologic role for somatostatin 28 as a regulator of insulin secretion." The Journal of Clinical Investigation 84, no. 3 (September 1989): 857-862. Full Text
- D'Alessio, DA, Kavle, EC, Mozzoli, MA, Smalley, KJ, Polansky, M, Kendrick, ZV, Owen, LR, Bushman, MC, Boden, G, and Owen, OE. "Thermic effect of food in lean and obese men." The Journal of Clinical Investigation 81, no. 6 (June 1988): 1781-1789. Full Text
- Owen, OE, Holup, JL, D'Alessio, DA, Craig, ES, Polansky, M, Smalley, KJ, Kavle, EC, Bushman, MC, Owen, LR, and Mozzoli, MA. "A reappraisal of the caloric requirements of men." The American Journal of Clinical Nutrition 46, no. 6 (December 1987): 875-885. Full Text
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Book Sections
- Tong, J, Sandoval, D, and D'Alessio, D. "Textbook of Diabetes." 2016. (Chapter)
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Conference Papers
- Chatterjee, R, Slentz, CA, Johnson, JL, Lin, PH, Muehlbauer, M, D'Alessio, DA, Svetkey, LP, and Edelman, D. "A Pilot Study of Potassium Supplements on Glucose Metabolism in African-American Adults with Prediabetes." 77th Scientific Sessions of the American-Diabetes-Association. San Diego, CA. June 9, 2017 - June 13, 2017.: AMER DIABETES ASSOC, June 1, 2017. Link to Item
- Coch, R, Campbell, J, and D'Alessio, DA. "The Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor Dapagliflozin Causes Ketosis In Nondiabetic and Diabetic Mice." June 1, 2017. Link to Item
- Douros, J, Niu, J, Sdao, S, Gregg, T, Merrins, MJ, Tong, J, Campbell, J, and D'Alessio, DA. "Does Bariatric Surgery Build Better Beta Cells? Vertical Sleeve Gastrectomy Stimulates Autonomous Improvements to Islet Function in Mice." June 1, 2017. Link to Item
- Encisco, S, Svendsen, B, D'Alessio, DA, and Campbell, J. "Glucagon Stimulates Insulin Secretion through Both Glucagon and GLP-1 Receptors." June 1, 2017. Link to Item
- Miller, MD, D'Alessio, DA, and Slentz, CA. "Beta-Cell Sensitivity to Incretin Infusions in Healthy Adults." June 1, 2017. Link to Item
- Niu, J, Campbell, J, D'Alessio, DA, and Tong, J. "Ghrelin Suppresses Insulin Secretion More Potently under Low Glucose than High Glucose in Rodents." June 1, 2017. Link to Item
- Rosario, W, D'Alessio, DA, and Rhodes, CJ. "Viral-Mediated GK Knockout in Specific Hypothalamic Nuclei Confirms Differential Regulation of Pancreatic Islet Physiology." June 1, 2017. Link to Item
- Telford, O, D'Alessio, DA, Eisenberg, A, Herbst, R, Hong, B, Bullock, WM, Martin, G, Manning, E, and Setji, T. "Perioperative Steroid Use for Knee and Hip Surgeries Increases Rates of Hyperglycemia but Is Associated with Reduced Length of Hospital Stays." June 1, 2017. Link to Item
- Chatha, S, Corbin, AE, Sisson, EM, Berger, KM, Woolf, B, Leonard, AC, D'Alessio, DA, and Falciglia, M. "Management of Inpatient Hypoglycemia: Improving Safety through The Joint Commission Standards." June 2016. Link to Item
- Polanco, GG, Corbin, AE, Sisson, EM, Smith, KB, Brumm, SD, D'Alessio, DA, and Falciglia, M. "Sweet Transitions: Coordinating Diabetes Care between Hospital and Primary Care Settings." June 2016. Link to Item
- An, Z, Smith, EP, Greer, T, Berger, J, and D'Alessio, DA. "The Role of GLP-1 Receptor Signaling in Metabolic Changes after Roux-en-Y Gastric Bypass in Diet Induced Obese Rats." : AMER DIABETES ASSOC, June 1, 2012. Link to Item
- Falciglia, M, Freyberg, RW, Almenoff, PL, D'Alessio, DA, and Render, ML. "Hyperglycemia during Critical Illness Predicts Future Diabetes." : AMER DIABETES ASSOC, June 1, 2012. Link to Item
- Inge, TH, Jenkins, TM, Elder, DA, Carr, AN, Jeffreys, RM, Spikes, C, Dolan, LM, Prigeon, RL, and D'Alessio, DA. "Improved Insulin Sensitivity and Decreased Insulin Secretion in Adolescents Undergoing Gastric Bypass." October 2010. Link to Item
- Kindel, TL, Martins, PJ, Yoder, SM, Seeley, RJ, D'Alessio, DA, Obici, S, and Tso, P. "Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents." September 2010. Full Text
- Burke, KT, D'Alessio, DA, and Woollett, LA. "Multiparity Programs Offspring To Have Increased Adiposity." June 2010. Link to Item
- Elder, DA, Woo, JG, and D'Alessio, DA. "Longitudinal Assessment of Beta-Cell Function in Adolescents Newly Diagnosed with T2DM Compared to Weight Matched Controls: Two Year Assessment." June 2010. Link to Item
- Salehi, M, Prigeon, RL, and D'Alessio, DA. "Postprandial Insulin Secretion and Clearance in Patients with Hyperinsulinemic Hypoglycemic Syndrome Following Gastric Bypass Surgery." June 2010. Link to Item
- D'Alessio, D. "Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV." September 2008. Full Text
- Aulinger, BA, Hassel, J, Roy, K, Elfers, EE, Woods, SC, Seeley, RJ, and D'Alessio, DA. "Peripheral effects of Ex-4 and GLP-1 on anorexia and weight loss." June 2008. Link to Item
- Aulinger, BA, Perabo, M, Has-Sel, J, Perez-Ptilve, D, Elfers, EE, Tschop, MH, Seeley, RJ, and D'Alessio, DA. "Ex-4 and the DPP-IV inhibitor vildagliptin have additive effects to suppress food intake in rodents." June 2008. Link to Item
- Elder, DA, Woo, JG, Dolan, LM, and D'alessio, DA. "Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes." June 2008. Link to Item
- Salehi, M, and D'Alessio, DA. "Intraindividual variation of the incretin-related insulin response during oral glucose tolerance test." June 2008. Link to Item
- Summer, SS, Brehm, BJ, Benoit, SC, and D'Alessio, DA. "The effects of diet composition and weight loss on serum adiponectin." June 2008. Link to Item
- Aulinger, BA, Vahl, TP, Elfers, EE, Elfers, CT, and D'Alessio, DA. "Antagonists of the GLP-1 receptor, ex-9 and dHis-Ex, block GIP action in vitro but not in vivo." June 2007. Link to Item
- Brehm, BJ, Lattin, BL, Summer, SS, Boback, JA, Gilchrist, GM, and D'Alessio, DA. "High monounsaturated fat and high carbohydrate diets are equally effective and acceptable in overweight and obese subjects with type 2 diabetes." June 2007. Link to Item
- Crimmins, NA, Khoury, JC, Daniels, SR, D'Alessio, DA, Dolan, LM, and Kirk, S. "Overweight youth: Low prevalence of glucose intolerance and diabetes." June 2007. Link to Item
- Elder, DA, D'Alessio, DA, and Rose, SR. "Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion." June 2007. Link to Item
- Elder, DA, Vahl, T, Dolan, LM, and D'Alessio, DA. "The incretin effect in adolescents with type 2 diabetes is not impaired." June 2007. Link to Item
- Falciglia, M, Freyberg, RW, Almenoff, PL, D'Alessio, DA, and Render, ML. "Severity of illness is not a major determinant of hyperglycemia in critically ill patients." June 2007. Link to Item
- Klustaitis, KM, Elfers, EE, and D'Alessio, DA. "Sensory neurons in the portal vein can access small molecules in circulation: Support for a neuro-endocrine mechanism of action of GLP-1." June 2007. Link to Item
- Ryan, KK, Aulinger, BA, D'Alessio, DA, Seeley, RJ, and Woods, SC. "Scheduled feeding improves postprandial glucose tolerance." June 2007. Link to Item
- Salehi, M, Aulinger, BA, and D'Alessio, DA. "The role of glucagon-like peptide-1 to stimulate postprandial insulin secretion in type 2 diabetes." June 2007. Link to Item
- Brehm, BJ, Lattin, BL, Summer, SS, Boback, JA, Gilchrist, GM, and D'Alessio, DA. "Randomized one-year comparison of high monounsaturated fat and high carbohydrate diets in subjects with type 2 diabetes." June 2006. Link to Item
- Crimmins, NA, Bean, JA, Daniels, SR, D'Alessio, DA, and Dolan, LM. "Infrequent abnormalities of carbohydrate metabolism despite high rates of obesity and insulin resistance in a longitudinal study of adolescents." June 2006. Link to Item
- D'Alessio, DA, Watson, CE, He, Y-L, Ligueros-Saylan, M, Wang, Y, Dunning, BE, Prigeon, RL, Foley, JE, and Pratley, RE. "Restoration of an acute insulin response to glucose (AIRg) in drug-naive patients with type diabetes (T2DM) by 3-month treatment with vildagliptin." June 2006. Link to Item
- Salehi, M, Rilo, HL, Ahmad, SA, Matthews, JB, Lowy, AM, and D'Alessio, DA. "Stability of insulin secretion following islet autotransplantation." June 2006. Link to Item
- Salehi, M, Vahl, T, and D'Alessio, DA. "Effect of endogenous GLP-1 on insulin secretion during oral glucose tolerance tests." June 2006. Link to Item
- Vahl, TP, Drazen, DL, Seeley, RJ, D'Alessio, DA, and Woods, SC. "Improved glucose tolerance in meal-fed rats is not regulated by GLP-1 or GIP." June 2006. Link to Item
- Teff, KL, Elliott, SS, Tschöp, M, Kieffer, TJ, Rader, D, Heiman, M, Townsend, RR, Keim, NL, D'Alessio, D, and Havel, PJ. "Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women." June 2004. Full Text
- Rodriguez Rilo, HL, Ahmad, SA, D'Alessio, D, Iwanaga, Y, Kim, J, Choe, KA, Moulton, JS, Martin, J, Pennington, LJ, Soldano, DA, Biliter, J, Martin, SP, Ulrich, CD, Somogyi, L, Welge, J, Matthews, JB, and Lowy, AM. "Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis." December 2003. Full Text
- D'Alessio, D. "Glucagon-like peptide 1 (GLP-1) in diabetes and aging." January 1, 2000. Full Text
- Paty, BW, Teague, J, and D'Alessio, DA. "Effects of GLP-1 [9-36] NH2, a metabolite of GLP-1 [7-36] NH2, on insulin secretion in Hamster Insulinoma Tumor (HIT) cells." February 15, 1996.
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