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David A D'Alessio

Lindquist McNeill Presidential Distinguished Chair
Medicine, Endocrinology, Metabolism, and Nutrition
DUMC Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Selected Grants


Establishing Memory in Adipose Tissue Influences Future Metabolic Outcomes in Obesity

ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2030

Metabolic Actions of Glucagon

ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2025 - 2030

A gut sense for dietary lysine

ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2030

Endocrinology and Metabolism Training Program

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

Alpha- to Beta-Cell Communication in Health and Disease

ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

Gut epithelial control of nutrient reward

ResearchCo-Mentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2028

Dissecting the Neural Circuitry Linking GLP-1 Receptor Agonists to Cardiovascular Health

ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2028

Zebrafish tools for enteroendocrine hormone biology

ResearchCo Investigator · Awarded by National Institutes of Health · 2026 - 2028

North Carolina Diabetes Research Center (NCDRC) - Duke site

ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2020 - 2028

Novel assays for proglucagon peptides to understand alpha cell function in health and diabetes

ResearchCo Investigator · Awarded by Leona M. and Harry B. Helmsley Charitable Trust · 2024 - 2027

Targeting alpha-cell GPCRs to stimulate glucagon and counter hypoglycemia

ResearchCo-Mentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2022 - 2027

Changing the T1DE: A randomized controlled trial comparing ACT to supportive diabetes counseling

ResearchCo Investigator · Awarded by Breakthrough T1D · 2022 - 2027

Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026

Rapid sugar sensing from gut to brain

FellowshipCo-Mentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2026

Injectable PEG-like Conjugate for Sustained Delivery of a Peptide Drug for Type 2 Diabetes Treatment

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2025

Novel metabolic actions of GIP

ResearchCo-Principal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2020 - 2025

Mechanisms of insulin secretion mediated by alpha cells

ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2024

Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolism

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2023

Mechanisms that Direct Airway Remodeling in Obese Asthma

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2023

Duke Training Grant in Nephrology

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023

Serotonin as a Novel Biomarker for Progression to Type 2 Diabetes in Obese Adolescents

ResearchAdvisor · Awarded by National Institutes of Health · 2018 - 2023

IPA-Leslie Kelly

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

IPA - Cris Slentz

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

IPA - Lucy Piner

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

IPA - Radha Krishna

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

Role of Islet GLP-1 and DPP-4 in Insulin Secretion

Clinical TrialPrincipal Investigator · Awarded by Merck Sharp & Dohme · 2015 - 2021

The Role of Islet DPP4 for Regulation of Glucose Homeostasis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2021

INCRETIN ACTION IN PHYSIOLOGY AND DIABETES

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2021

IPA - Lorraine Elliott-Penry

Clinical TrialPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2019 - 2021

Nutrient-dependent action of glucagon and GLP-1 in glucose metabolism and insulin secretion

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2020

Assessing the Role of Glucose-Dependent Insulinotropic Polypeptide to Mediate Improved Beta-Cell Function Following Bariatric Surgery

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019

IPA - Andrew Hoselton

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2017 - 2019

IPA- Leslie Kelly

ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2017 - 2019

Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer

EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019

The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes

ResearchInvestigator · Awarded by National Institutes of Health · 2013 - 2019

The Role of Vitamin D in Established Type 2 Diabetes

ResearchPrincipal Investigator · Awarded by Tufts Medical Center · 2015 - 2018

A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety and Efficacy of LGD-6972 in Patients with Type 2 Diabetes Mellitus

Clinical TrialPrincipal Investigator · Awarded by Ligand Pharmaceuticals, Inc. · 2016 - 2017

The Role of Glucagon in Diabetic Ketoacidosis

ResearchPrincipal Investigator · Awarded by Endocrine Fellows Foundation · 2016 - 2017

External Relationships


  • Advent Health- Translational Research Institute
  • American Diabetes Association
  • AstraZeneca
  • BriiBio
  • Ecco gene
  • Eli Lilly & Co.
  • General Medicines
  • MBX Bioscience
  • Mass Med
  • Structure Therapeutics
  • Sun Pharmaceuticals
  • Vertex Pharmaceuticals Inc.

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.