Scholars@Duke
David Hasan

David Hasan

Professor of Neurosurgery
Neurosurgery
david.hasan@duke.edu
200 Trent Dr, DUMC 3807, Durham, NC 27710
200 Trent Dr, Box 3807, Durham, NC 27710

Scholarly Works - Conferences

2078 Elimination of Senescent Cells Prevents Intracranial Aneurysm Rupture

Conference Neurosurgery · April 2025 INTRODUCTION:Clinical studies have demonstrated an association between aging and the risk of intracranial aneurysm rupture. As a result of aging, various changes in cellul ... Full text Cite

Abstract TMP110: Impact of Microplastics and Nanoplastics on Ischemic Stroke in Mice

Conference Stroke · February 2025 Introduction: Over the past few decades, plastics have been widely used in many products. Recently, the potential ingestion of plastic debris called microplastics and nanoplastics (MNPs) and their tox ... Full text Cite

Abstract WMP114: Clonal hematopoiesis of indeterminate potential promotes the development of intracranial aneurysm rupture

Conference Stroke · February 2025 Introduction: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is characterized by the expansion of a blood-cell clone due to somatic mutation in hematopoietic stem cells, in the absence of othe ... Full text Cite

Abstract WMP112: Elimination of Senescent Cells with Immune Checkpoint Inhibitor Prevents Intracranial Aneurysm Rupture

Conference Stroke · February 2025 Introduction: Clinical studies have shown an association between aging and the risk of intracranial aneurysm rupture. Aging leads to various changes in cellular homeostasis, including the onset of cel ... Full text Cite

Abstract WP368: Novel Brain Penetrant Manganese Porphyrin-Based SOD Mimic Improves Short-Term Outcomes of Subarachnoid Hemorrhage

Conference Stroke · February 2025 Introduction: Oxidative stress plays an important role in both early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Despite the beneficial effects demonstrated in prec ... Full text Cite

Abstract 75: The Uterus and Vascular Endothelial Growth Factor; A Novel Organ-Hormone Axis in the Pathogenesis of Intracranial Aneurysms

Conference Stroke · February 2025 Background: Female gender is a well-established risk factor for intracranial aneurysms (IA), with women showing a 3:1 prevalence, 2:1 rupture risk, and higher aneurysm multiplicity. This risk has also ... Full text Cite

High-Resolution Micro-CT Imaging Protocols for Studies of Intracranial Aneurysms in Murine Models

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Unruptured intracranial aneurysms (UIAs) pose significant clinical challenges due to their risk of growth and rupture. Early and accurate imaging is essential for effective management and understanding their pathophysiology. This study integrates three adv ... Full text Cite

Signaling Pathways Regulated by Nitrated Proteins in Glioblastoma Multiforme

Conference Free Radical Biology and Medicine · November 2024 Full text Cite

Abstract TP290: A Pilot Study of a Novel Brain Penetrant Mn(III) Porphyrin-Based Sod Mimic on Middle Cerebral Artery Occlusion in Female and Male Mice

Conference Stroke · February 2024 Introduction: Oxidative stress exacerbates acute ischemic stroke (AIS). Manganese Porphyrin (MnP)-based superoxide dismutase (SOD) mimics have shown therapeutic benefits for AIS. However, earlier MnP ... Full text Cite

Abstract 15: Pharmacological Activation of Efferocytosis Prevents Intracranial Aneurysm Rupture

Conference Stroke · February 2024 Introduction: Efferocytosis is the clearance process of dead or dying cells that reduces the tissue-damaging effects of excessive apoptotic cells. The accumulation of apoptotic cells at higher levels ... Full text Cite

Abstract TMP114: The Role of Iron Mediated Oxidative Stress and Lipid Peroxidation in the Development of Intracranial Aneurysm Rupture

Conference Stroke · February 2024 Introduction: Iron is an essential element for vascular wall maintenance. However, iron deposition in the vascular wall may cause oxidative stress, which can attack DNA, proteins, and lipid membranes ... Full text Cite

Minimally Invasive Deep Brain Stimulation Using Intracranial Stents

Conference 2021 IEEE International Symposium on Antennas and Propagation and North American Radio Science Meeting Aps Ursi 2021 Proceedings · January 1, 2021 Deep brain stimulation is a multipurpose therapy indicated for a host of neuropsychiatric disorders including treatment resistant depression, Parkinson's disease, and refractory epilepsy. However, current systems require invasive surgery and have a high ri ... Full text Cite

Novel Treatment of Cerebral Vasospasm Using Solitaire Stent Retriever-Assisted Angioplasty: Case Series.

Conference World Neurosurg · March 2020 BACKGROUND: Endovascular procedures such as intraarterial (IA) vasodilator injection and balloon angioplasty are used to treat medically refractory cerebral vasospasm. The effects of IA therapy may be short lived and thus require multiple treatments. Ballo ... Full text Link to item Cite

Cerebral aneurysm sac growth as the etiology of recurrence after successful coil embolization

Conference ASME 2012 Summer Bioengineering Conference Sbc 2012 · December 1, 2012 Full text Cite

Comparison of imaging modalities in the quantification of cerebral aneurysm geometry

Conference ASME 2010 Summer Bioengineering Conference Sbc 2010 · December 1, 2010 Full text Cite