David Guy Kirsch
Barbara Levine University Distinguished Professor
My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.
Current Appointments & Affiliations
- Barbara Levine University Distinguished Professor, Radiation Oncology, Clinical Science Departments 2016
- Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015
- Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- Duke Box 91006, Durham, NC 27708
- LSRC Building, Room B327, Durham, NC 27710
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david.kirsch@duke.edu
(919) 681-8586
- Background
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Education, Training, & Certifications
- M.D., Johns Hopkins University School of Medicine 2000
- Ph.D., Johns Hopkins University School of Medicine 2000
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Duke Appointment History
- Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012 - 2015
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2012 - 2015
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2008 - 2012
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2008
- Recognition
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In the News
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NOV 21, 2017 -
MAY 5, 2016 -
MAR 18, 2016 -
JAN 8, 2016 CBS News -
JAN 7, 2016 The Daily Mail -
JAN 7, 2016 TIME -
JAN 6, 2016 -
AUG 1, 2013 WRAL.com
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- Research
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Selected Grants
- Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma awarded by National Institutes of Health 2021 - 2026
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- Employing Novel Primary Mouse Models of Head and Neck Cancer to Overcome Chemoradiation Resistance awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Multi-scale characterization of radiation resistance in head and neck squamous cell carcinoma awarded by Department of Defense 2021 - 2024
- Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health 2020 - 2024
- Defining Gene Regulatory Elements Essential to Cancer Cell Viability awarded by National Institutes of Health 2019 - 2023
- Evaluating and Targeting Pathways of Treatment Resistance in Head and Neck Squamous Cell Carcinoma awarded by Damon Runyon Cancer Research Foundation 2020 - 2023
- Role of MST/Hippo kinase inactivation in driving fusion-positive rhabdomyosarcoma awarded by National Institutes of Health 2020 - 2023
- Dissecting the role of ATRX in soft tissue sarcoma development and radiation response awarded by National Institutes of Health 2020 - 2023
- Advancing Cancer Therapy through Ground Breaking Research in Radiation Biology awarded by National Institutes of Health 2016 - 2022
- The Duke Pre-Clinical Research Resources for Quantitative Imaging Biomarkers awarded by National Institutes of Health 2017 - 2022
- Harnessing NK Cells to Treat Pediatric Cancers awarded by American Association for Cancer Research 2020 - 2022
- Enhancing the efficacy of radiation therapy for brainstem gliomas awarded by St. Baldrick's Foundation 2020 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- A console for magnetic resonance histology awarded by North Carolina Biotechnology Center 2021 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Examining Biosynthesis and NAD+ Demand in the Warburg Effect awarded by National Institutes of Health 2019 - 2022
- Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition awarded by Pediatric Brain Tumor Foundation 2019 - 2022
- Flourine-18 labeled MDM2 antagonists for PET imaging awarded by National Institutes of Health 2020 - 2022
- Enhancing the efficacy of radiation therapy for DIPG awarded by Michael Mosier Defeat DIPG Foundation 2020 - 2021
- Targeting epigenetic dysregulation in pediatric cancer awarded by Dana-Farber Cancer Institute 2019 - 2021
- Evaluation of kinase inhibitors awarded by XRAD THERAPEUTICS, INC. 2016 - 2021
- Pembroluzimab and Radiation Therapy to Improve Outcome in Localized High-Risk Sarcoma awarded by American Association for Cancer Research 2017 - 2021
- Dissecting Mechanisms of T cell Exhaustion in Autochthonous Tumors awarded by The Leon Levine Foundation 2020 - 2021
- Dissecting Mechanisms by which p53 Suppresses Transformation and Radiation Carcinogenesis awarded by National Institutes of Health 2020 - 2021
- Understanding methionine metabolism and its therapeutic potential in cancer awarded by National Institutes of Health 2019 - 2021
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Defining the Landscape and Function of Onco-exaptation and Repetitive Element-Derived Tumor Specific Antigens in Undifferentiated Pleomorphic Sarcoma awarded by Connective Tissue Oncology Society 2020 - 2021
- Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance awarded by National Institutes of Health 2017 - 2021
- Dissecting the Role of Clonal Evolution in Tumor Response and Resistance to Radiation and Immunotherapy awarded by Goldman Sachs Philanthropy Fund 2019 - 2021
- Dissecting the role of the immune system in the radiation response of KRAS-mutant tumors awarded by National Institutes of Health 2017 - 2021
- Mining biology's extremes for new space radiation resistance strategies awarded by Baylor College of Medicine 2017 - 2020
- Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma awarded by V Foundation for Cancer Research 2016 - 2020
- Clinical Trials Umbrella - Scanned Beam awarded by Massachusetts General Hospital 2019 - 2020
- Identifying the metabolic dependencies of primary sarcoma and sarcoma lung metastases awarded by The Alan B. Slifka Foundation 2018 - 2020
- Modeling the impact of radiation protectors on radiation-induced sarcoma risk awarded by Department of Defense 2018 - 2020
- Increase radiation response of brainstem gliomas to increase survival of children and maintain their neurological function. awarded by The Leon Levine Foundation 2018 - 2020
- Using CRISPR/Cas9 to dissect the role of FUS-CHOP in tumor response to radiation therapy awarded by National Institutes of Health 2016 - 2020
- Clinical Trials Umbrella - Scanned Beam awarded by Massachusetts General Hospital 2016 - 2019
- Investigating the role of the transcriptional coactivator TAZ in alveolar rhabdomyosarcoma awarded by St. Baldrick's Foundation 2016 - 2019
- Investigating 1E10 Fc as a radiosensitizer in primary mouse sarcomas awarded by Eli Lilly and Company 2017 - 2019
- Role of ErbB Receptor Signaling in Regulating Normal and Leukemic Stem Cell Fate awarded by National Institutes of Health 2014 - 2019
- St. Baldrick's Summer Fellows awarded by St. Baldrick's Foundation 2019
- Awakening the dormant tumor: the role of the tumor microenvironment in breast cancer recurrence awarded by National Institutes of Health 2017 - 2019
- Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2015 - 2018
- SARC Spore - Bridge Funding awarded by Sarcoma Alliance for Research Through Collaboration 2017 - 2018
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
- Radiosensitization of brainstem gliomas by targeting ATM awarded by St. Baldrick's Foundation 2017 - 2018
- Seahorse XFe96 Extracellular Flux Analyzer awarded by North Carolina Biotechnology Center 2017 - 2018
- Dissecting the Mechanisms of Immune Mediated Radiation Resistance in Sarcomas awarded by Sarcoma Foundation of America 2017 - 2018
- An Activatable Nanoparticle Probe for Molecular Imaging of Protease Activity by Dual Energy CT awarded by National Institutes of Health 2015 - 2018
- Gertrude B Elion Award - Amy Wisdom awarded by Triangle Community Foundation 2016 - 2018
- The role of MST1 in non-canonical Hippo signaling in rhabdomyosarcoma awarded by Alex's Lemonade Stand 2015 - 2018
- Defining the role of miR-182 in HZE-induced tumorignesis awarded by National Aeronautics and Space Administration 2014 - 2018
- Non-Canonical Responses to DNA damage in Drosophila Polyploid Cells awarded by National Institutes of Health 2015 - 2017
- A novel therap[eutic target for radiation-induced hematological malignancies: calcium calmodulin kinase kinase 2 awarded by Department of Defense 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Mechanisms that Regulate Sarcoma Response to Immune Checkpoint Inhibition of PD-1 awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Mechanisms that Regulate Sarcoma Response to Immune Checkpoint Inhibition of PD-1 awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Training Grant in Radiation Biology awarded by Vanderbilt University 2016 - 2017
- Testing current and developing novel therapies for NF1-mutant sarcomas in a genetically engineered mouse model awarded by Department of Defense 2014 - 2017
- Janssen Research AGreement awarded by Janssen Research & Development, LLC 2014 - 2016
- Muscle-Resident Stem Cells for Angiogenesis and Vascular Maturation in PAD awarded by National Institutes of Health 2013 - 2016
- Intraoperative detection and ablation of microscopic residual cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Independent Scientist Award for Radiation Research awarded by National Institutes of Health 2011 - 2016
- Duke NSCOR: Lung Cancer Risk from HZE Ions awarded by National Aeronautics and Space Administration 2011 - 2016
- Radiation Therapy: Dissecting the Role of Stromal Cells in Tumor Control awarded by National Institutes of Health 2013 - 2016
- Defining the Cellular Target of Radiation Therapy awarded by National Institutes of Health 2014 - 2015
- Evaluating GSK2126458 with radiation therapy in pre-clinical models awarded by GlaxoSmithKline 2013 - 2015
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Modulation of Endothelial Cell Radiation Sensitivity and Lung Tumor Response to Radiation Therapy awarded by Rsna Research & Education Fund 2014 - 2015
- Dissecting the roles of HIF-1a and HIF-2a in tumor response to radiation therapy awarded by National Institutes of Health 2013 - 2015
- Defining the cellular target of radiotherapy in primary mouse models of cancer awarded by National Institutes of Health 2013 - 2015
- SARC Sarcoma SPORE - Developmental Research Program awarded by Sarcoma Alliance for Research Through Collaboration 2013 - 2015
- Engineered imaging nanoparticles for real-time detection of cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2015
- Dissecting Mechanisms of Metastasis Through Comparative Systems Genetics awarded by National Institutes of Health 2008 - 2013
- Mechanisms of Late Effects of Exposure to Radiation awarded by National Institutes of Health 2008 - 2013
- A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment awarded by National Institutes of Health 2011 - 2013
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Image-Guided Radiation Therapy and Radiosurgery for Small Animals awarded by National Institutes of Health 2009 - 2011
- Intravital point-scanning confocal microscope awarded by National Institutes of Health 2010 - 2011
- Imaging Lung Cancer in Mice to Improve Radiation Therapy awarded by National Institutes of Health 2005 - 2010
- Dissecting Mechanism of GI Syndrome to Restore Function after Radiation Exposure awarded by National Institutes of Health 2007 - 2010
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External Relationships
- Bristol-Myers Squibb
- Lumicell Inc
- Merck Sharpe & Dohme (Merck & Co, USA)
- Varian Medical Systems
- X-Rad Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Salama, Joseph K., Scott R. Floyd, Christopher G. Willett, and David G. Kirsch. “Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.” Int J Radiat Oncol Biol Phys 110, no. 2 (June 1, 2021): 288–91. https://doi.org/10.1016/j.ijrobp.2020.12.050.Full Text Link to Item
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Lee, Chang-Lung, Kennedy D. Brock, Stephanie Hasapis, Dadong Zhang, Alexander B. Sibley, Xiaodi Qin, Jeremy S. Gresham, et al. “Whole exome sequencing of radiation-induced thymic lymphoma in mouse models identifies Notch1 activation as a driver of p53 wild-type lymphoma.” Cancer Res, May 25, 2021. https://doi.org/10.1158/0008-5472.CAN-20-2823.Full Text Link to Item
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Schmidt, Daniel R., Rutulkumar Patel, David G. Kirsch, Caroline A. Lewis, Matthew G. Vander Heiden, and Jason W. Locasale. “Metabolomics in cancer research and emerging applications in clinical oncology.” Ca Cancer J Clin, May 13, 2021. https://doi.org/10.3322/caac.21670.Full Text Link to Item
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Ancey, Pierre-Benoit, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, et al. “GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.” Cancer Res 81, no. 9 (May 1, 2021): 2345–57. https://doi.org/10.1158/0008-5472.CAN-20-2870.Full Text Link to Item
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Lee, Chang-Lung, Jessica W. Lee, Andrea R. Daniel, Matt Holbrook, Stephanie Hasapis, Ato O. Wright, Jeremy Brownstein, et al. “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.” Radiother Oncol 157 (April 2021): 155–62. https://doi.org/10.1016/j.radonc.2021.01.023.Full Text Link to Item
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Deland, Katherine, Bryce F. Starr, Joshua S. Mercer, Jovita Byemerwa, Donna M. Crabtree, Nerissa T. Williams, Lixia Luo, et al. “Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.” J Clin Invest 131, no. 1 (January 4, 2021). https://doi.org/10.1172/JCI142158.Full Text Link to Item
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Wisdom, Amy J., Yvonne M. Mowery, Cierra S. Hong, Jonathon E. Himes, Barzin Y. Nabet, Xiaodi Qin, Dadong Zhang, et al. “Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.” Nat Commun 11, no. 1 (December 17, 2020): 6410. https://doi.org/10.1038/s41467-020-19917-0.Full Text Link to Item
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Wisdom, Amy J., and David G. Kirsch. “Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.” Cancer Res 80, no. 24 (December 15, 2020): 5459–61. https://doi.org/10.1158/0008-5472.CAN-20-3241.Full Text Link to Item
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Kirsch, David G. “Radiation Therapy as a Treatment for COVID-19?” Int J Radiat Oncol Biol Phys 108, no. 5 (December 1, 2020): 1140–42. https://doi.org/10.1016/j.ijrobp.2020.07.025.Full Text Link to Item
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Prasanna, Pataje G., Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, et al. “Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?” Radiat Res 194, no. 5 (November 10, 2020): 452–64. https://doi.org/10.1667/RADE-20-00211.1.Full Text Link to Item
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Lee, Jessica W., Diana M. Cardona, Dan G. Blazer, and David G. Kirsch. “Response to Central Boost Radiation Therapy in an Unresectable Retroperitoneal Sarcoma: A Case Report.” Adv Radiat Oncol 5, no. 6 (November 2020): 1375–79. https://doi.org/10.1016/j.adro.2020.05.012.Full Text Link to Item
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Liu, Shiyu, Ziwei Dai, Daniel E. Cooper, David G. Kirsch, and Jason W. Locasale. “Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle.” Cell Metab 32, no. 4 (October 6, 2020): 619-628.e21. https://doi.org/10.1016/j.cmet.2020.09.005.Full Text Link to Item
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Huang, Jianguo, Mohit Sachdeva, Eric Xu, Timothy J. Robinson, Lixia Luo, Yan Ma, Nerissa T. Williams, et al. “The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways.” Mol Cancer Res 18, no. 10 (October 2020): 1534–44. https://doi.org/10.1158/1541-7786.MCR-19-1170.Full Text Link to Item
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Dodd, Rebecca D., Amanda Scherer, Wesley Huang, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Kathleen A. Ashcraft, et al. “Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.” Clin Cancer Res 26, no. 18 (September 15, 2020): 5036–47. https://doi.org/10.1158/1078-0432.CCR-19-2597.Full Text Link to Item
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Daniel, Andrea R., Chang-Lung Lee, Patrick Oh, Lixia Luo, Yan Ma, and David G. Kirsch. “Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice.” Health Phys 119, no. 3 (September 2020): 315–21. https://doi.org/10.1097/HP.0000000000001243.Full Text Link to Item
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Yoon, Suk W., Jacob Kodra, Devin A. Miles, David G. Kirsch, and Mark Oldham. “A method for generating intensity-modulated radiation therapy fields for small animal irradiators utilizing 3D-printed compensator molds.” Med Phys 47, no. 9 (September 2020): 4363–71. https://doi.org/10.1002/mp.14175.Full Text Link to Item
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Kirsch, David G., Maximilian Diehn, Francis A. Cucinotta, and Ralph Weichselbaum. “Response Letter: Radiation therapy for COVID-19 pneumopathy.” Radiother Oncol 149 (August 2020): 238–39. https://doi.org/10.1016/j.radonc.2020.05.048.Full Text Link to Item
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Dial, Brian L., David L. Kerr, Alexander L. Lazarides, Anthony A. Catanzano, Cindy L. Green, Thomas Risoli, Dan G. Blazer, et al. “The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.” Spine (Phila Pa 1976) 45, no. 12 (June 15, 2020): E742–51. https://doi.org/10.1097/BRS.0000000000003406.Full Text Link to Item
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Kirsch, David G., Maximilian Diehn, Francis A. Cucinotta, and Ralph Weichselbaum. “Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable.” Radiother Oncol 147 (June 2020): 217–20. https://doi.org/10.1016/j.radonc.2020.04.060.Full Text Link to Item
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Binder, Christina, Prithvi Mruthyunjaya, Amy C. Schefler, Michael I. Seider, Richard Crilly, Arthur Hung, Sheridan Meltsner, et al. “Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.” Ocul Oncol Pathol 6, no. 3 (May 2020): 210–18. https://doi.org/10.1159/000504312.Full Text Link to Item
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Huang, Qiang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, et al. “Intravital imaging of mouse embryos.” Science 368, no. 6487 (April 10, 2020): 181–86. https://doi.org/10.1126/science.aba0210.Full Text Open Access Copy Link to Item
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Holbrook, M. D., S. J. Blocker, Y. M. Mowery, A. Badea, Y. Qi, E. S. Xu, D. G. Kirsch, G. A. Johnson, and C. T. Badea. “MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.” Tomography 6, no. 1 (March 2020): 23–33. https://doi.org/10.18383/j.tom.2019.00021.Full Text Link to Item
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Rakhilin, Nikolai, Aliesha Garrett, Chi-Yong Eom, Katherine Ramos Chavez, David M. Small, Andrea R. Daniel, Melanie M. Kaelberer, et al. “An intravital window to image the colon in real time.” Nat Commun 10, no. 1 (December 11, 2019): 5647. https://doi.org/10.1038/s41467-019-13699-w.Full Text Link to Item
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Huang, Jianguo, Mark Chen, Eric S. Xu, Lixia Luo, Yan Ma, Wesley Huang, Warren Floyd, et al. “Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.” Sci Rep 9, no. 1 (November 20, 2019): 17220. https://doi.org/10.1038/s41598-019-53572-w.Full Text Open Access Copy Link to Item
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Castle, Katherine D., and David G. Kirsch. “Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy.” Cancer Res 79, no. 22 (November 15, 2019): 5685–92. https://doi.org/10.1158/0008-5472.CAN-19-1323.Full Text Link to Item
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Whitley, Melodi Javid, Willis Barrow, Oana I. Craciunescu, Michelle Pavlis, and David G. Kirsch. “Kaposi sarcoma in a patient with postpolio syndrome.” Cutis 104, no. 5 (November 2019): E20–22.Link to Item
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Yohe, Marielle E., Christine M. Heske, Elizabeth Stewart, Peter C. Adamson, Nabil Ahmed, Cristina R. Antonescu, Eleanor Chen, et al. “Insights into pediatric rhabdomyosarcoma research: Challenges and goals.” Pediatr Blood Cancer 66, no. 10 (October 2019): e27869. https://doi.org/10.1002/pbc.27869.Full Text Link to Item
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Tang, Yuning J., Jianguo Huang, Hidetoshi Tsushima, Ga I. Ban, Hongyuan Zhang, Kristianne M. Oristian, Vijitha Puviindran, et al. “Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.” Cell Rep 28, no. 11 (September 10, 2019): 2837-2850.e5. https://doi.org/10.1016/j.celrep.2019.08.029.Full Text Link to Item
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Wisdom, Amy J., Cierra S. Hong, Alexander J. Lin, Yu Xiang, Daniel E. Cooper, Jin Zhang, Eric S. Xu, et al. “Neutrophils promote tumor resistance to radiation therapy.” Proc Natl Acad Sci U S A 116, no. 37 (September 10, 2019): 18584–89. https://doi.org/10.1073/pnas.1901562116.Full Text Link to Item
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Lee, Chang-Lung, Andrea R. Daniel, Matt Holbrook, Jeremy Brownstein, Lorraine Da Silva Campos, Stephanie Hasapis, Yan Ma, Luke B. Borst, Cristian T. Badea, and David G. Kirsch. “Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.” Radiat Res 192, no. 3 (September 2019): 258–66. https://doi.org/10.1667/RR15371.1.Full Text Link to Item
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Gao, Xia, Sydney M. Sanderson, Ziwei Dai, Michael A. Reid, Daniel E. Cooper, Min Lu, John P. Richie, et al. “Dietary methionine influences therapy in mouse cancer models and alters human metabolism.” Nature 572, no. 7769 (August 2019): 397–401. https://doi.org/10.1038/s41586-019-1437-3.Full Text Link to Item
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Lee, Chang-Lung, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, et al. “Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.” Jci Insight 4, no. 13 (July 11, 2019). https://doi.org/10.1172/jci.insight.128698.Full Text Link to Item
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Chen, Mark, and David G. Kirsch. “Safely combining trabectedin with radiotherapy to treat myxoid liposarcoma.” Eclinicalmedicine 9 (March 2019): 5–6. https://doi.org/10.1016/j.eclinm.2019.03.015.Full Text Link to Item
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Wisdom, Amy J., and David G. Kirsch. “Functional assay to guide precision radiotherapy by assessing individual patient radiosensitivity.” Ebiomedicine 41 (March 2019): 26–27. https://doi.org/10.1016/j.ebiom.2019.03.002.Full Text Link to Item
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Torok, Jordan A., Patrick Oh, Katherine D. Castle, Michael Reinsvold, Yan Ma, Lixia Luo, Chang-Lung Lee, and David G. Kirsch. “Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.” Cancer Res 79, no. 4 (February 15, 2019): 773–82. https://doi.org/10.1158/0008-5472.CAN-17-3103.Full Text Link to Item
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Song, Erin J., Kathleen A. Ashcraft, Caitlin D. Lowery, Yvonne M. Mowery, Lixia Luo, Yan Ma, Lorraine Da Silva Campos, Diana M. Cardona, Louis Stancato, and David G. Kirsch. “Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas.” Ebiomedicine 40 (February 2019): 224–30. https://doi.org/10.1016/j.ebiom.2019.01.046.Full Text Link to Item
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Blocker, S. J., Y. M. Mowery, M. D. Holbrook, Y. Qi, D. G. Kirsch, G. A. Johnson, and C. T. Badea. “Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial.” Plos One 14, no. 4 (2019): e0207555. https://doi.org/10.1371/journal.pone.0207555.Full Text Open Access Copy Link to Item
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Catanzano, Anthony A., David L. Kerr, Alexander L. Lazarides, Brian L. Dial, Whitney O. Lane, Dan G. Blazer, Nicole A. Larrier, David G. Kirsch, Brian E. Brigman, and William C. Eward. “Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.” Sarcoma 2019 (2019): 4878512. https://doi.org/10.1155/2019/4878512.Full Text Link to Item
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Chen, Mark, Eric S. Xu, Nathan H. Leisenring, Diana M. Cardona, Lixia Luo, Yan Ma, Andrea Ventura, and David G. Kirsch. “The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice.” Sarcoma 2019 (2019): 1340261. https://doi.org/10.1155/2019/1340261.Full Text Link to Item
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Lee, Chang-Lung, Patrick Oh, Eric S. Xu, Yan Ma, Yongbaek Kim, Andrea R. Daniel, and David G. Kirsch. “Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.” Int J Radiat Oncol Biol Phys 102, no. 5 (December 1, 2018): 1569–76. https://doi.org/10.1016/j.ijrobp.2018.07.192.Full Text Link to Item
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Van Mater, David, Eric Xu, Anupama Reddy, Leonor Añó, Mohit Sachdeva, Wesley Huang, Nerissa Williams, et al. “Injury promotes sarcoma development in a genetically and temporally restricted manner.” Jci Insight 3, no. 20 (October 18, 2018). https://doi.org/10.1172/jci.insight.123687.Full Text Link to Item
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Inoue, Kazuki, Zhonghao Deng, Yufan Chen, Eugenia Giannopoulou, Ren Xu, Shiaoching Gong, Matthew B. Greenblatt, et al. “Bone protection by inhibition of microRNA-182.” Nat Commun 9, no. 1 (October 5, 2018): 4108. https://doi.org/10.1038/s41467-018-06446-0.Full Text Link to Item
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Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, et al. “Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.” Cell 175, no. 2 (October 4, 2018): 502-513.e13. https://doi.org/10.1016/j.cell.2018.08.040.Full Text Link to Item
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Oristian, Kristianne M., Lisa E. S. Crose, Nina Kuprasertkul, Rex C. Bentley, Yi-Tzu Lin, Nerissa Williams, David G. Kirsch, and Corinne M. Linardic. “Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.” Cancer Res 78, no. 19 (October 1, 2018): 5513–20. https://doi.org/10.1158/0008-5472.CAN-17-3912.Full Text Link to Item
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Wisdom, Amy J., Yvonne M. Mowery, Richard F. Riedel, and David G. Kirsch. “Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.” Cancer 124, no. 19 (October 1, 2018): 3819–29. https://doi.org/10.1002/cncr.31517.Full Text Link to Item
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Cheung, Phyllis F., Florian Neff, Christian Neander, Anna Bazarna, Konstantinos Savvatakis, Sven-Thorsten Liffers, Kristina Althoff, et al. “Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.” Cancer Res 78, no. 17 (September 1, 2018): 4997–5010. https://doi.org/10.1158/0008-5472.CAN-18-0052.Full Text Link to Item
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Peacock, Jacqueline D., Matthew G. Pridgeon, Elizabeth A. Tovar, Curt J. Essenburg, Megan Bowman, Zachary Madaj, Julie Koeman, et al. “Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors.” Cancer Res 78, no. 13 (July 1, 2018): 3672–87. https://doi.org/10.1158/0008-5472.CAN-17-3167.Full Text Link to Item
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Castle, Katherine D., Andrea R. Daniel, Everett J. Moding, Lixia Luo, Chang-Lung Lee, and David G. Kirsch. “Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome.” Radiat Res 189, no. 6 (June 2018): 627–33. https://doi.org/10.1667/RR15001.1.Full Text Link to Item
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Kirsch, David G. “Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology.” Int J Radiat Oncol Biol Phys 101, no. 2 (June 1, 2018): 267–70. https://doi.org/10.1016/j.ijrobp.2017.04.005.Full Text Link to Item
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Grilley-Olson, Juneko E., Nicholas P. Webber, David S. Demos, Jared D. Christensen, and David G. Kirsch. “Multidisciplinary Management of Oligometastatic Soft Tissue Sarcoma.” Am Soc Clin Oncol Educ Book 38 (May 23, 2018): 939–48. https://doi.org/10.1200/EDBK_200573.Full Text Link to Item
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Ahmed, Mansoor M., C Norman Coleman, Marc Mendonca, Soren Bentzen, Bhadrasain Vikram, Stephen M. Seltzer, Dudley Goodhead, et al. “Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.” Cancer Res 78, no. 9 (May 1, 2018): 2166–70. https://doi.org/10.1158/0008-5472.CAN-17-3760.Full Text Link to Item
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Bristow, Robert G., Brian Alexander, Michael Baumann, Scott V. Bratman, J Martin Brown, Kevin Camphausen, Peter Choyke, et al. “Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology.” Lancet Oncol 19, no. 5 (May 2018): e240–51. https://doi.org/10.1016/S1470-2045(18)30096-2.Full Text Link to Item
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Brownstein, Jeremy M., Amy J. Wisdom, Katherine D. Castle, Yvonne M. Mowery, Peter Guida, Chang-Lung Lee, Francesco Tommasino, et al. “Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.” Mol Cancer Ther 17, no. 4 (April 2018): 858–68. https://doi.org/10.1158/1535-7163.MCT-17-0965.Full Text Link to Item
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Dewhirst, Mark W., and David Kirsch. “Technological Advances, Biologic Rationales, and the Associated Success of Chemotherapy With Hyperthermia in Improved Outcomes in Patients With Sarcoma.” Jama Oncol 4, no. 4 (April 1, 2018): 493–94. https://doi.org/10.1001/jamaoncol.2017.4941.Full Text Link to Item
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Kirsch, David G., Max Diehn, Aparna H. Kesarwala, Amit Maity, Meredith A. Morgan, Julie K. Schwarz, Robert Bristow, et al. “The Future of Radiobiology.” J Natl Cancer Inst 110, no. 4 (April 1, 2018): 329–40. https://doi.org/10.1093/jnci/djx231.Full Text Link to Item
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Hsu, Shu-Hsuan Claire, Puviindran Nadesan, Vijitha Puviindran, William B. Stallcup, David G. Kirsch, and Benjamin A. Alman. “Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.” J Biol Chem 293, no. 7 (February 16, 2018): 2466–75. https://doi.org/10.1074/jbc.M117.805051.Full Text Link to Item
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Oellers, Patrick, Yvonne M. Mowery, Bradford A. Perez, Sandra Stinnett, Pradeep Mettu, Lejla Vajzovic, Kim Light, et al. “Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.” Am J Ophthalmol 186 (February 2018): 32–40. https://doi.org/10.1016/j.ajo.2017.11.008.Full Text Link to Item
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Ashton, Jeffrey R., Katherine D. Castle, Yi Qi, David G. Kirsch, Jennifer L. West, and Cristian T. Badea. “Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.” Theranostics 8, no. 7 (2018): 1782–97. https://doi.org/10.7150/thno.22621.Full Text Open Access Copy Link to Item
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Kane, John M., Anthony Magliocco, Qiang Zhang, Dian Wang, Alex Klimowicz, Jonathan Harris, Jeff Simko, Thomas DeLaney, William Kraybill, and David G. Kirsch. “Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation.” Sarcoma 2018 (2018): 8310950. https://doi.org/10.1155/2018/8310950.Full Text Link to Item
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Liu, Xiaojing, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, and Jason W. Locasale. “De Novo Acetate Production is Coupled to Central Carbon Metabolism in Mammals,” 2018.
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Yoon, Suk W., Christina K. Cramer, Devin A. Miles, Michael H. Reinsvold, Kyeung M. Joo, David G. Kirsch, and Mark Oldham. “A precision 3D conformal treatment technique in rats: Application to whole-brain radiotherapy with hippocampal avoidance.” Med Phys 44, no. 11 (November 2017): 6008–17. https://doi.org/10.1002/mp.12533.Full Text Link to Item
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Dodd, Rebecca D., Chang-Lung Lee, Tess Overton, Wesley Huang, William C. Eward, Lixia Luo, Yan Ma, et al. “NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.” Cancer Res 77, no. 16 (August 15, 2017): 4486–97. https://doi.org/10.1158/0008-5472.CAN-16-2643.Full Text Link to Item
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Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.” Nat Commun 8 (July 10, 2017): 15999. https://doi.org/10.1038/ncomms15999.Full Text Link to Item
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Castle, Katherine D., Mark Chen, Amy J. Wisdom, and David G. Kirsch. “Genetically engineered mouse models for studying radiation biology.” Transl Cancer Res 6, no. Suppl 5 (July 2017): S900–913. https://doi.org/10.21037/tcr.2017.06.19.Full Text Link to Item
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McConnell, Alicia M., Changfu Yao, Alyson R. Yeckes, Yizhou Wang, Anna S. Selvaggio, Jie Tang, David G. Kirsch, and Barry R. Stripp. “p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.” Cell Rep 17, no. 9 (November 22, 2016): 2173–82. https://doi.org/10.1016/j.celrep.2016.11.007.Full Text Link to Item
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Kent, C. L., Y. M. Mowery, A. J. Wisdom, D. Van Mater, K. D. Castle, A. Reddy, S. S. Dave, and D. G. Kirsch. “Immune Checkpoint Inhibition and Radiation Therapy in 2 Primary Mouse Models of Soft Tissue Sarcoma: Impact of Tumor Mutational Load.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E578–79. https://doi.org/10.1016/j.ijrobp.2016.06.2077.Full Text Link to Item
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Larrier, Nicole A., Brian G. Czito, and David G. Kirsch. “Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy.” Surg Oncol Clin N Am 25, no. 4 (October 2016): 841–60. https://doi.org/10.1016/j.soc.2016.05.012.Full Text Link to Item
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McConnell, Alicia M., Bindu Konda, David G. Kirsch, and Barry R. Stripp. “Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation.” Sci Rep 6 (September 23, 2016): 33455. https://doi.org/10.1038/srep33455.Full Text Link to Item
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Chitalia, Rhea, Jenna Mueller, Henry L. Fu, Melodi Javid Whitley, David G. Kirsch, J Quincy Brown, Rebecca Willett, and Nimmi Ramanujam. “Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.” Biomed Opt Express 7, no. 9 (September 1, 2016): 3412–24. https://doi.org/10.1364/BOE.7.003412.Full Text Link to Item
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Bartholf DeWitt, Suzanne, William C. Eward, Cindy A. Eward, Alexander L. Lazarides, Melodi Javid Whitley, Jorge M. Ferrer, Brian E. Brigman, David G. Kirsch, and John Berg. “A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.” Vet Surg 45, no. 6 (August 2016): 715–22. https://doi.org/10.1111/vsu.12487.Full Text Link to Item
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Sato, Shingo, Yuning J. Tang, Qingxia Wei, Makoto Hirata, Angela Weng, Ilkyu Han, Atsushi Okawa, et al. “Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.” Cell Rep 16, no. 4 (July 26, 2016): 917–27. https://doi.org/10.1016/j.celrep.2016.06.058.Full Text Link to Item
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Moding, Everett J., Hooney D. Min, Katherine D. Castle, Moiez Ali, Loretta Woodlief, Nerissa Williams, Yan Ma, Yongbaek Kim, Chang-Lung Lee, and David G. Kirsch. “An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer.” Jci Insight 1, no. 10 (July 7, 2016). https://doi.org/10.1172/jci.insight.86698.Full Text Link to Item
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Coleman, C Norman, Geoff S. Higgins, J Martin Brown, Michael Baumann, David G. Kirsch, Henning Willers, Pataje G. S. Prasanna, Mark W. Dewhirst, Eric J. Bernhard, and Mansoor M. Ahmed. “Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.” Clin Cancer Res 22, no. 13 (July 1, 2016): 3138–47. https://doi.org/10.1158/1078-0432.CCR-16-0069.Full Text Link to Item
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Li, X Allen, Xiaojian Chen, Qiang Zhang, David G. Kirsch, Ivy Petersen, Thomas F. DeLaney, Carolyn R. Freeman, et al. “Margin reduction from image guided radiation therapy for soft tissue sarcoma: Secondary analysis of Radiation Therapy Oncology Group 0630 results.” Pract Radiat Oncol 6, no. 4 (July 2016): e135–40. https://doi.org/10.1016/j.prro.2015.11.012.Full Text Link to Item
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Moding, Everett J., Yvonne M. Mowery, and David G. Kirsch. “Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.” Cancer J 22, no. 4 (July 2016): 267–73. https://doi.org/10.1097/PPO.0000000000000203.Full Text Link to Item
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Nussbaum, Daniel P., Christel N. Rushing, Whitney O. Lane, Diana M. Cardona, David G. Kirsch, Bercedis L. Peterson, and Dan G. Blazer. “Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database.” Lancet Oncol 17, no. 7 (July 2016): 966–75. https://doi.org/10.1016/S1470-2045(16)30050-X.Full Text Link to Item
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Whitley, Melodi Javid, Adela R. Cardones, Oana I. Craciunescu, and David G. Kirsch. “Externally applied high-dose-rate brachytherapy for deeply invasive cutaneous squamous cell carcinoma in an older patient.” Pract Radiat Oncol 6, no. 4 (July 2016): e141–44. https://doi.org/10.1016/j.prro.2015.11.008.Full Text Link to Item
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Kim, Kyu-Tae, Hye Won Lee, Hae-Ock Lee, Hye Jin Song, Da Eun Jeong, Sang Shin, Hyunho Kim, et al. “Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma.” Genome Biol 17 (April 29, 2016): 80. https://doi.org/10.1186/s13059-016-0945-9.Full Text Link to Item
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Dodd, R. D., M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, and D. G. Kirsch. “Myogenic transcription factors regulate pro-metastatic miR-182.” Oncogene 35, no. 14 (April 7, 2016): 1868–75. https://doi.org/10.1038/onc.2015.252.Full Text Link to Item
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Sachdeva, Mohit, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, et al. “MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.” J Clin Invest 126, no. 4 (April 1, 2016): 1606. https://doi.org/10.1172/JCI86573.Full Text Link to Item
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Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.Full Text Link to Item
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Lazarides, Alexander L., Melodi J. Whitley, David B. Strasfeld, Diana M. Cardona, Jorge M. Ferrer, Jenna L. Mueller, Henry L. Fu, et al. “A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.” Theranostics 6, no. 2 (2016): 155–66. https://doi.org/10.7150/thno.13536.Full Text Open Access Copy Link to Item
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Oldham, Mark, Paul Yoon, Zak Fathi, Wayne F. Beyer, Justus Adamson, Leihua Liu, David Alcorta, et al. “X-Ray Psoralen Activated Cancer Therapy (X-PACT).” Plos One 11, no. 9 (2016): e0162078. https://doi.org/10.1371/journal.pone.0162078.Full Text Open Access Copy Link to Item
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Sachdeva, Mohit, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, and David G. Kirsch. “Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.” Cancer Lett 369, no. 1 (December 1, 2015): 202–11. https://doi.org/10.1016/j.canlet.2015.08.016.Full Text Link to Item
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Mueller, Jenna L., Henry L. Fu, Jeffrey K. Mito, Melodi J. Whitley, Rhea Chitalia, Alaattin Erkanli, Leslie Dodd, et al. “A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.” Int J Cancer 137, no. 10 (November 15, 2015): 2403–12. https://doi.org/10.1002/ijc.29611.Full Text Link to Item
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Clark, Darin P., Chang-Lung Lee, David G. Kirsch, and Cristian T. Badea. “Spectrotemporal CT data acquisition and reconstruction at low dose.” Med Phys 42, no. 11 (November 2015): 6317–36. https://doi.org/10.1118/1.4931407.Full Text Open Access Copy Link to Item
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Kirsch, David G. “Biomarkers for Predicting Radiation Response.” Semin Radiat Oncol 25, no. 4 (October 2015): 225–26. https://doi.org/10.1016/j.semradonc.2015.05.011.Full Text Link to Item
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Whitley, Melodi J., Ralph Weissleder, and David G. Kirsch. “Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer.” Semin Radiat Oncol 25, no. 4 (October 2015): 313–21. https://doi.org/10.1016/j.semradonc.2015.05.005.Full Text Link to Item
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Lee, Chang-Lung, Katherine D. Castle, Everett J. Moding, Jordan M. Blum, Nerissa Williams, Lixia Luo, Yan Ma, Luke B. Borst, Yongbaek Kim, and David G. Kirsch. “Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.” Nat Commun 6 (September 24, 2015): 8477. https://doi.org/10.1038/ncomms9477.Full Text Link to Item
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Brown, J Martin, Bradly G. Wouters, and David G. Kirsch. “Cell Death Identification in Anticancer Therapy-Letter.” Cancer Res 75, no. 17 (September 1, 2015): 3681. https://doi.org/10.1158/0008-5472.CAN-15-0908.Full Text Link to Item
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Hou, Chun-Han, Alexander L. Lazarides, Paul J. Speicher, Daniel P. Nussbaum, Daniel G. Blazer, David G. Kirsch, Brian E. Brigman, and William C. Eward. “The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.” Ann Surg Oncol 22, no. 9 (September 2015): 2831–38. https://doi.org/10.1245/s10434-015-4639-4.Full Text Link to Item
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Lane, Whitney O., Christina K. Cramer, Daniel P. Nussbaum, Paul J. Speicher, Brian C. Gulack, Brian G. Czito, David G. Kirsch, Douglas S. Tyler, and Dan G. Blazer. “Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.” J Surg Oncol 112, no. 4 (September 2015): 352–58. https://doi.org/10.1002/jso.23996.Full Text Link to Item
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Sachdeva, Mohit, Melodi J. Whitley, Jeffrey K. Mito, Yan Ma, Dina C. Lev, Diana M. Cardona, and David G. Kirsch. “MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.” Dis Model Mech 8, no. 9 (September 2015): 1169. https://doi.org/10.1242/dmm.022582.Full Text Link to Item
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Zhang, Minsi, and David G. Kirsch. “The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis.” Dis Model Mech 8, no. 9 (September 2015): 1155–66. https://doi.org/10.1242/dmm.021204.Full Text Link to Item
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Sachdeva, Mohit, Melody J. Whitley, Jeffrey K. Mito, Yan Ma, Dina C. Lev, Diana M. Cardona, and David G. Kirsch. “MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.” Dis Model Mech 8, no. 8 (August 1, 2015): 867–75. https://doi.org/10.1242/dmm.017897.Full Text Link to Item
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Wang, Dian, Qiang Zhang, Burton L. Eisenberg, John M. Kane, X Allen Li, David Lucas, Ivy A. Petersen, et al. “Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial.” J Clin Oncol 33, no. 20 (July 10, 2015): 2231–38. https://doi.org/10.1200/JCO.2014.58.5828.Full Text Link to Item
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Baldini, Elizabeth H., Dian Wang, Rick L. M. Haas, Charles N. Catton, Daniel J. Indelicato, David G. Kirsch, David Roberge, et al. “Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel.” Int J Radiat Oncol Biol Phys 92, no. 3 (July 1, 2015): 602–12. https://doi.org/10.1016/j.ijrobp.2015.02.013.Full Text Link to Item
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Barcellos-Hoff, Mary Helen, Eleanor A. Blakely, Sandeep Burma, Albert J. Fornace, Stanton Gerson, Lynn Hlatky, David G. Kirsch, et al. “Concepts and challenges in cancer risk prediction for the space radiation environment.” Life Sci Space Res (Amst) 6 (July 2015): 92–103. https://doi.org/10.1016/j.lssr.2015.07.006.Full Text Link to Item
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Nussbaum, Daniel P., Paul J. Speicher, Brian C. Gulack, Asvin M. Ganapathi, Brian R. Englum, David G. Kirsch, Douglas S. Tyler, and Dan G. Blazer. “Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas.” Ann Surg 262, no. 1 (July 2015): 163–70. https://doi.org/10.1097/SLA.0000000000000840.Full Text Link to Item
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Zhang, Minsi, Qiong Qiu, Zhizhong Li, Mohit Sachdeva, Hooney Min, Diana M. Cardona, Thomas F. DeLaney, et al. “HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.” Radiat Res 183, no. 6 (June 2015): 594–609. https://doi.org/10.1667/RR14016.1.Full Text Link to Item
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Moding, Everett J., Katherine D. Castle, Bradford A. Perez, Patrick Oh, Hooney D. Min, Hannah Norris, Yan Ma, Diana M. Cardona, Chang-Lung Lee, and David G. Kirsch. “Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy.” Sci Transl Med 7, no. 278 (March 11, 2015): 278ra34. https://doi.org/10.1126/scitranslmed.aaa4214.Full Text Link to Item
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Lee, Hae-June, Changhwan Yoon, Do Joong Park, Yeo-Jung Kim, Benjamin Schmidt, Yoon-Jin Lee, William D. Tap, et al. “Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.” Int J Radiat Oncol Biol Phys 91, no. 3 (March 1, 2015): 621–30. https://doi.org/10.1016/j.ijrobp.2014.10.047.Full Text Link to Item
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Bache, Steven T., Titania Juang, Matthew D. Belley, Bridget F. Koontz, John Adamovics, Terry T. Yoshizumi, David G. Kirsch, and Mark Oldham. “Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters.” Med Phys 42, no. 2 (February 2015): 846–55. https://doi.org/10.1118/1.4905489.Full Text Link to Item
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Van Mater, David, Leonor Añó, Jordan M. Blum, Micah T. Webster, WeiQiao Huang, Nerissa Williams, Yan Ma, Diana M. Cardona, Chen-Ming Fan, and David G. Kirsch. “Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.” Cancer Res 75, no. 3 (February 1, 2015): 605–14. https://doi.org/10.1158/0008-5472.CAN-14-2527.Full Text Link to Item
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Cramer, C. K., S. W. Yoon, M. Reinsvold, K. M. Joo, H. Norris, R. C. Hood, J. D. Adamson, R. C. Klein, D. G. Kirsch, and M. Oldham. “Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats.” Plos One 10, no. 12 (2015): e0143208. https://doi.org/10.1371/journal.pone.0143208.Full Text Link to Item
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Dodd, Rebecca D., Leonor Añó, Jordan M. Blum, Zhizhong Li, David Van Mater, and David G. Kirsch. “Methods to generate genetically engineered mouse models of soft tissue sarcoma.” Methods Mol Biol 1267 (2015): 283–95. https://doi.org/10.1007/978-1-4939-2297-0_13.Full Text Link to Item
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Farin, Alicia M., Nicholas D. Manzo, David G. Kirsch, and Barry R. Stripp. “Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo.” Radiat Res 183, no. 1 (January 2015): 124–32. https://doi.org/10.1667/RR13878.1.Full Text Link to Item
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Lazarides, Alexander L., William C. Eward, Paul J. Speicher, Chun-Han Hou, Daniel P. Nussbaum, Cindy Green, Dan G. Blazer, David G. Kirsch, and Brian E. Brigman. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.” Sarcoma 2015 (2015): 186581. https://doi.org/10.1155/2015/186581.Full Text Link to Item
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Liu, Yang, Jeffrey R. Ashton, Everett J. Moding, Hsiangkuo Yuan, Janna K. Register, Andrew M. Fales, Jaeyeon Choi, et al. “A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.” Theranostics 5, no. 9 (2015): 946–60. https://doi.org/10.7150/thno.11974.Full Text Open Access Copy Link to Item
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Asada, Ken, Emanuele Canestrari, Xiuping Fu, Zhi Li, Edward Makowski, Yen-Ching Wu, Jeffrey K. Mito, David G. Kirsch, Jay Baraban, and Zain Paroo. “Rescuing dicer defects via inhibition of an anti-dicing nuclease.” Cell Rep 9, no. 4 (November 20, 2014): 1471–81. https://doi.org/10.1016/j.celrep.2014.10.021.Full Text Link to Item
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Schönhuber, Nina, Barbara Seidler, Kathleen Schuck, Christian Veltkamp, Christina Schachtler, Magdalena Zukowska, Stefan Eser, et al. “A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.” Nat Med 20, no. 11 (November 2014): 1340–47. https://doi.org/10.1038/nm.3646.Full Text Link to Item
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Wong, Philip, Peter Houghton, David G. Kirsch, Steven E. Finkelstein, Arta M. Monjazeb, Meng Xu-Welliver, Adam P. Dicker, et al. “Combining targeted agents with modern radiotherapy in soft tissue sarcomas.” J Natl Cancer Inst 106, no. 11 (November 2014). https://doi.org/10.1093/jnci/dju329.Full Text Link to Item
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Sachdeva, Mohit, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, et al. “MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.” J Clin Invest 124, no. 10 (October 2014): 4305–19. https://doi.org/10.1172/JCI77116.Full Text Link to Item
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Phesse, Toby J., Michael Buchert, Emma Stuart, Dustin J. Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, et al. “Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.” Sci Signal 7, no. 345 (September 30, 2014): ra92. https://doi.org/10.1126/scisignal.2005411.Full Text Link to Item
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Coleman, C Norman, Theodore S. Lawrence, and David G. Kirsch. “Enhancing the efficacy of radiation therapy: premises, promises, and practicality.” J Clin Oncol 32, no. 26 (September 10, 2014): 2832–35. https://doi.org/10.1200/JCO.2014.57.3865.Full Text Link to Item
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Nussbaum, Daniel P., Paul J. Speicher, Brian C. Gulack, Asvin M. Ganapathi, Jeffrey E. Keenan, Sandra S. Stinnett, David G. Kirsch, Douglas S. Tyler, and Dan G. Blazer. “The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas.” Surg Oncol 23, no. 3 (September 2014): 155–60. https://doi.org/10.1016/j.suronc.2014.07.001.Full Text Link to Item
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Khanna, Chand, Timothy M. Fan, Richard Gorlick, Lee J. Helman, Eugenie S. Kleinerman, Peter C. Adamson, Peter J. Houghton, et al. “Toward a drug development path that targets metastatic progression in osteosarcoma.” Clin Cancer Res 20, no. 16 (August 15, 2014): 4200–4209. https://doi.org/10.1158/1078-0432.CCR-13-2574.Full Text Link to Item
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Moding, Everett J., Chang-Lung Lee, Katherine D. Castle, Patrick Oh, Lan Mao, Shan Zha, Hooney D. Min, Yan Ma, Shiva Das, and David G. Kirsch. “Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.” J Clin Invest 124, no. 8 (August 2014): 3325–38. https://doi.org/10.1172/JCI73932.Full Text Link to Item
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Stanton, Ian N., Matthew D. Belley, Giao Nguyen, Anna Rodrigues, Yifan Li, David G. Kirsch, Terry T. Yoshizumi, and Michael J. Therien. “Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure.” Nanoscale 6, no. 10 (May 21, 2014): 5284–88. https://doi.org/10.1039/c4nr00497c.Full Text Link to Item
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Lee, Chang-Lung, Everett J. Moding, and David G. Kirsch. “Reining in radiation injury: HIF2α in the gut.” Sci Transl Med 6, no. 236 (May 14, 2014): 236fs20. https://doi.org/10.1126/scitranslmed.3009155.Full Text Link to Item
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Lee, Chang-Lung, William E. Lento, Katherine D. Castle, Nelson J. Chao, and David G. Kirsch. “Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice.” Radiat Res 181, no. 5 (May 2014): 445–51. https://doi.org/10.1667/RR13692.1.Full Text Link to Item
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Perez, Bradford A., Pradeep Mettu, Lejla Vajzovic, Douglas Rivera, Ali Alkaissi, Beverly A. Steffey, Jing Cai, et al. “Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes.” Int J Radiat Oncol Biol Phys 89, no. 1 (May 1, 2014): 127–36. https://doi.org/10.1016/j.ijrobp.2014.01.026.Full Text Link to Item
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Lee, Chang-Lung, Hooney Min, Nicholas Befera, Darin Clark, Yi Qi, Shiva Das, G Allan Johnson, Cristian T. Badea, and David G. Kirsch. “Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.” Int J Radiat Oncol Biol Phys 88, no. 3 (March 1, 2014): 686–93. https://doi.org/10.1016/j.ijrobp.2013.11.238.Full Text Open Access Copy Link to Item
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Ashton, Jeffrey R., Darin P. Clark, Everett J. Moding, Ketan Ghaghada, David G. Kirsch, Jennifer L. West, and Cristian T. Badea. “Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study.” Plos One 9, no. 2 (2014): e88129. https://doi.org/10.1371/journal.pone.0088129.Full Text Open Access Copy Link to Item
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Wallner, Paul E., Mitchell S. Anscher, Christopher A. Barker, Michael Bassetti, Robert G. Bristow, Yong I. Cha, Adam P. Dicker, et al. “Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary.” Int J Radiat Oncol Biol Phys 88, no. 1 (January 1, 2014): 11–17. https://doi.org/10.1016/j.ijrobp.2013.09.040.Full Text Link to Item
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Zhang, Minsi, Corinne M. Linardic, and David G. Kirsch. “RAS and ROS in rhabdomyosarcoma.” Cancer Cell 24, no. 6 (December 9, 2013): 689–91. https://doi.org/10.1016/j.ccr.2013.11.015.Full Text Link to Item
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Blum, Jordan M., Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, Mohit Sachdeva, Irina Lagutina, et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.” Cell Rep 5, no. 4 (November 27, 2013): 933–40. https://doi.org/10.1016/j.celrep.2013.10.020.Full Text Link to Item
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Fu, H. L., J. L. Mueller, M. Javid, D. G. Kirsch, N. Ramanujam, and J. Q. Brown. “Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins.” Cleo: Applications and Technology, Cleo at 2013, November 19, 2013.
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Rankine, L. J., J. Newton, S. T. Bache, S. K. Das, J. Adamovics, D. G. Kirsch, and M. Oldham. “Investigating end-to-end accuracy of image guided radiation treatment delivery using a micro-irradiator.” Phys Med Biol 58, no. 21 (November 7, 2013): 7791–7801. https://doi.org/10.1088/0031-9155/58/21/7791.Full Text Link to Item
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Lee, Hae-June, Changhwan Yoon, Benjamin Schmidt, Do Joong Park, Alexia Y. Zhang, Hayriye V. Erkizan, Jeffrey A. Toretsky, David G. Kirsch, and Sam S. Yoon. “Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.” Mol Cancer Ther 12, no. 11 (November 2013): 2591–2600. https://doi.org/10.1158/1535-7163.MCT-13-0338.Full Text Link to Item
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Eisinger-Mathason, TS Karin, Minsi Zhang, Qiong Qiu, Nicolas Skuli, Michael S. Nakazawa, Tatiana Karakasheva, Vera Mucaj, et al. “Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.” Cancer Discov 3, no. 10 (October 2013): 1190–1205. https://doi.org/10.1158/2159-8290.CD-13-0118.Full Text Link to Item
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Lee, Chang-Lung, Jordan M. Blum, and David G. Kirsch. “Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.” Transl Cancer Res 2, no. 5 (October 2013): 412–21.Link to Item
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Dodd, Rebecca D., Jeffrey K. Mito, William C. Eward, Rhea Chitalia, Mohit Sachdeva, Yan Ma, Jordi Barretina, Leslie Dodd, and David G. Kirsch. “NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.” Mol Cancer Ther 12, no. 9 (September 2013): 1906–17. https://doi.org/10.1158/1535-7163.MCT-13-0189.Full Text Link to Item
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Chen, Yen-Lin, Norbert Liebsch, Wendy Kobayashi, Saveli Goldberg, David Kirsch, Geoffrey Calkins, Stephanie Childs, Joseph Schwab, Francis Hornicek, and Thomas DeLaney. “Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas.” Spine (Phila Pa 1976) 38, no. 15 (July 1, 2013): E930–36. https://doi.org/10.1097/BRS.0b013e318296e7d7.Full Text Link to Item
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Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.Full Text Link to Item
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Moding, Everett J., Michael B. Kastan, and David G. Kirsch. “Strategies for optimizing the response of cancer and normal tissues to radiation.” Nat Rev Drug Discov 12, no. 7 (July 2013): 526–42. https://doi.org/10.1038/nrd4003.Full Text Link to Item
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Bahig, Houda, David Roberge, Walter Bosch, William Levin, Ivy Petersen, Michael Haddock, Carolyn Freeman, et al. “Agreement among RTOG sarcoma radiation oncologists in contouring suspicious peritumoral edema for preoperative radiation therapy of soft tissue sarcoma of the extremity.” Int J Radiat Oncol Biol Phys 86, no. 2 (June 1, 2013): 298–303. https://doi.org/10.1016/j.ijrobp.2013.01.032.Full Text Link to Item
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Mueller, J. L., Z. T. Harmany, J. K. Mito, S. A. Kennedy, Y. Kim, L. Dodd, J. Geradts, et al. “Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Approach for tuning algorithm parameters.” Progress in Biomedical Optics and Imaging Proceedings of Spie 8587 (May 27, 2013). https://doi.org/10.1117/12.2006429.Full Text
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Li, Zhizhong, Yunyu Zhang, Krishnan Ramanujan, Yan Ma, David G. Kirsch, and David J. Glass. “Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway.” Cancer Res 73, no. 10 (May 15, 2013): 3041–50. https://doi.org/10.1158/0008-5472.CAN-12-3947.Full Text Link to Item
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Cuneo, Kyle C., Jeffrey K. Mito, Melodi P. Javid, Jorge M. Ferrer, Yongbaek Kim, W David Lee, Moungi G. Bawendi, Brian E. Brigman, and David G. Kirsch. “Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents.” Int J Radiat Oncol Biol Phys 86, no. 1 (May 1, 2013): 136–42. https://doi.org/10.1016/j.ijrobp.2012.12.007.Full Text Link to Item
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Moding, Everett J., Darin P. Clark, Yi Qi, Yifan Li, Yan Ma, Ketan Ghaghada, G Allan Johnson, David G. Kirsch, and Cristian T. Badea. “Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas.” Int J Radiat Oncol Biol Phys 85, no. 5 (April 1, 2013): 1353–59. https://doi.org/10.1016/j.ijrobp.2012.09.027.Full Text Link to Item
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Clark, Darin P., Ketan Ghaghada, Everett J. Moding, David G. Kirsch, and Cristian T. Badea. “In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT.” Phys Med Biol 58, no. 6 (March 21, 2013): 1683–1704. https://doi.org/10.1088/0031-9155/58/6/1683.Full Text Link to Item
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Doan, Phuong L., Heather A. Himburg, Katherine Helms, J Lauren Russell, Emma Fixsen, Mamle Quarmyne, Jeffrey R. Harris, et al. “Epidermal growth factor regulates hematopoietic regeneration after radiation injury.” Nat Med 19, no. 3 (March 2013): 295–304. https://doi.org/10.1038/nm.3070.Full Text Open Access Copy Link to Item
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Eward, William C., Jeffrey K. Mito, Cindy A. Eward, Jessica E. Carter, Jorge M. Ferrer, David G. Kirsch, and Brian E. Brigman. “A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.” Clin Orthop Relat Res 471, no. 3 (March 2013): 834–42. https://doi.org/10.1007/s11999-012-2560-8.Full Text Link to Item
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Doan, Phuong L., J Lauren Russell, Heather A. Himburg, Katherine Helms, Jeffrey R. Harris, Joseph Lucas, Kirsten C. Holshausen, et al. “Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury.” Stem Cells 31, no. 2 (February 2013): 327–37. https://doi.org/10.1002/stem.1275.Full Text Link to Item
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Subashi, Ergys, Everett J. Moding, Gary P. Cofer, James R. MacFall, David G. Kirsch, Yi Qi, and G Allan Johnson. “A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models.” Med Phys 40, no. 2 (February 2013): 022304. https://doi.org/10.1118/1.4774050.Full Text Link to Item
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Li, Z., J. A. Gilbert, Y. Zhang, M. Zhang, Q. Qiu, K. Ramanujan, T. Shavlakadze, et al. “An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis.” Developmental Cell 24, no. 1 (January 14, 2013): 112. https://doi.org/10.1016/j.devcel.2012.12.007.Full Text
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Barton, Kelly L., Katherine Misuraca, Francisco Cordero, Elena Dobrikova, Hooney D. Min, Matthias Gromeier, David G. Kirsch, and Oren J. Becher. “PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.” Plos One 8, no. 10 (2013): e77639. https://doi.org/10.1371/journal.pone.0077639.Full Text Link to Item
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Fu, H. L., J. L. Mueller, M. Javid, D. G. Kirsch, N. Ramanujam, and J. Q. Brown. “Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins.” 2013 Conference on Lasers and Electro Optics, Cleo 2013, January 1, 2013. https://doi.org/10.1364/cleo_at.2013.ath1n.3.Full Text
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Fu, Henry L., Jenna L. Mueller, Melodi P. Javid, Jeffrey K. Mito, David G. Kirsch, Nimmi Ramanujam, and J Quincy Brown. “Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma.” Plos One 8, no. 7 (2013): e68868. https://doi.org/10.1371/journal.pone.0068868.Full Text Link to Item
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Mito, Jeffrey K., Hooney D. Min, Yan Ma, Jessica E. Carter, Brian E. Brigman, Leslie Dodd, David Dankort, Martin McMahon, and David G. Kirsch. “Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.” J Pathol 229, no. 1 (January 2013): 132–40. https://doi.org/10.1002/path.4099.Full Text Link to Item
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Mueller, Jenna L., Zachary T. Harmany, Jeffrey K. Mito, Stephanie A. Kennedy, Yongbaek Kim, Leslie Dodd, Joseph Geradts, et al. “Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins.” Plos One 8, no. 6 (2013): e66198. https://doi.org/10.1371/journal.pone.0066198.Full Text Link to Item
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Perez, Bradford A., A Paiman Ghafoori, Chang-Lung Lee, Samuel M. Johnston, Yifan Li, Jacob G. Moroshek, Yan Ma, et al. “Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice.” Front Oncol 3 (2013): 72. https://doi.org/10.3389/fonc.2013.00072.Full Text Open Access Copy Link to Item
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Li, Zhizhong, Jason A. Gilbert, Yunyu Zhang, Minsi Zhang, Qiong Qiu, Krishnan Ramanujan, Tea Shavlakadze, et al. “An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.” Dev Cell 23, no. 6 (December 11, 2012): 1176–88. https://doi.org/10.1016/j.devcel.2012.10.019.Full Text Link to Item
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Mito, Jeffrey K., Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, et al. “Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.” Cancer 118, no. 21 (November 1, 2012): 5320–30. https://doi.org/10.1002/cncr.27458.Full Text Link to Item
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Cuneo, Kyle C., Richard F. Riedel, Leslie G. Dodd, David H. Harpole, and David G. Kirsch. “Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy.” J Clin Oncol 30, no. 28 (October 1, 2012): e291–93. https://doi.org/10.1200/JCO.2012.42.8797.Full Text Link to Item
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Wang, Dian, Walter Bosch, David Roberge, Steven E. Finkelstein, Ivy Petersen, Michael Haddock, Yen-Lin E. Chen, et al. “In Reply to O'Sullivan et al.” Int J Radiat Oncol Biol Phys 84, no. 2 (October 1, 2012): 307–8. https://doi.org/10.1016/j.ijrobp.2012.05.038.Full Text Link to Item
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Lee, Chang-Lung, Everett J. Moding, Kyle C. Cuneo, Yifan Li, Julie M. Sullivan, Lan Mao, Iman Washington, et al. “p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.” Sci Signal 5, no. 234 (July 24, 2012): ra52. https://doi.org/10.1126/scisignal.2002918.Full Text Link to Item
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Rodrigues, A., G. Nguyen, Y. Li, K. Roy Choudhury, D. Kirsch, S. Das, and T. Yoshizumi. “SU-E-T-275: Dose Verification in a Small Animal Image-Guided Radiation Therapy X-Ray Machine: A Dose Comparison between TG-61 Based Look-Up Table and MOSFET Method for Various Collimator Sizes.” Med Phys 39, no. 6Part14 (June 2012): 3766. https://doi.org/10.1118/1.4735343.Full Text Link to Item
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Lee, Chang-Lung, Everett J. Moding, Xiaofang Huang, Yifan Li, Loretta Z. Woodlief, Rafaela C. Rodrigues, Yan Ma, and David G. Kirsch. “Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.” Dis Model Mech 5, no. 3 (May 2012): 397–402. https://doi.org/10.1242/dmm.009084.Full Text Link to Item
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Lee, Chang-Lung, Jordan M. Blum, Everett J. Moding, Julie M. Sullivan, Laura B. Jeffords, Rafaela C. Rodrigues, Yan Ma, Yongbaek Kim, and David G. Kirsch. “Abstract 4812: p53 acts during total-body irradiation to promote lymphomagenesis.” Carcinogenesis, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-4812.Full Text
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Sullivan, Julie M., Laura B. Jeffords, Chang-Lung Lee, Rafaela Rodrigues, Yan Ma, and David G. Kirsch. “p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.” Radiat Res 177, no. 3 (March 2012): 307–10. https://doi.org/10.1667/rr2545.1.Full Text Link to Item
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Badea, Cristian T., Khannan K. Athreya, Gabriela Espinosa, Darin Clark, A Paiman Ghafoori, Yifan Li, David G. Kirsch, G Allan Johnson, Ananth Annapragada, and Ketan B. Ghaghada. “Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.” Plos One 7, no. 4 (2012): e34496. https://doi.org/10.1371/journal.pone.0034496.Full Text Open Access Copy Link to Item
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Bell, Robert C., Deevakar Rogith, Craig W. Johnson, Cristian T. Badea, Khannan K. Athreya, Gabriela Espinosa, Darin Clark, et al. “Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model.” Amia Annu Symp Proc 2012 (2012): 27–35.Link to Item
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Belyea, Brian, Julie Grondin Kephart, Jordan Blum, David G. Kirsch, and Corinne M. Linardic. “Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.” Sarcoma 2012 (2012): 406239. https://doi.org/10.1155/2012/406239.Full Text Link to Item
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Kim, Suzy, Rebecca D. Dodd, Jeffrey K. Mito, Yan Ma, Yongbaek Kim, Richard F. Riedel, and David G. Kirsch. “Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma.” Sarcoma 2012 (2012): 680708. https://doi.org/10.1155/2012/680708.Full Text Link to Item
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Newton, Joseph, Mark Oldham, Andrew Thomas, Yifan Li, John Adamovics, David G. Kirsch, and Shiva Das. “Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques.” Med Phys 38, no. 12 (December 2011): 6754–62. https://doi.org/10.1118/1.3663675.Full Text Link to Item
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Omotosho, Philip, Basil Yurcisin, Eugene Ceppa, Jeffrey Miller, David Kirsch, and Dana D. Portenier. “In vivo assessment of an absorbable and nonabsorbable knotless barbed suture for laparoscopic single-layer enterotomy closure: a clinical and biomechanical comparison against nonbarbed suture.” J Laparoendosc Adv Surg Tech A 21, no. 10 (December 2011): 893–97. https://doi.org/10.1089/lap.2011.0281.Full Text Link to Item
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Wang, Dian, Walter Bosch, David G. Kirsch, Rawan Al Lozi, Issam El Naqa, David Roberge, Steven E. Finkelstein, et al. “Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists.” Int J Radiat Oncol Biol Phys 81, no. 5 (December 1, 2011): e775–80. https://doi.org/10.1016/j.ijrobp.2010.11.033.Full Text Link to Item
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Wang, Dian, Walter Bosch, David Roberge, Steven E. Finkelstein, Ivy Petersen, Michael Haddock, Yen-Lin E. Chen, et al. “RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies.” Int J Radiat Oncol Biol Phys 81, no. 4 (November 15, 2011): e525–28. https://doi.org/10.1016/j.ijrobp.2011.04.038.Full Text Link to Item
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Yoon, Sam S., Dan G. Duda, Daniel L. Karl, Tae-Min Kim, Avinash R. Kambadakone, Yen-Lin Chen, Courtney Rothrock, et al. “Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.” Int J Radiat Oncol Biol Phys 81, no. 4 (November 15, 2011): 1081–90. https://doi.org/10.1016/j.ijrobp.2010.07.024.Full Text Link to Item
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Lowe, C. B. “Three periods of regulatory innovation during vertebrate evolution (Science (1019)).” Science 334, no. 6057 (November 11, 2011): 761. https://doi.org/10.1126/science.334.6057.761-b.Full Text
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Cuneo, K. C., J. K. Mito, B. E. Brigman, J. M. Ferrer, C. Lee, W. C. Eward, J. E. Carter, and D. G. Kirsch. “Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S729–30. https://doi.org/10.1016/j.ijrobp.2011.06.1300.Full Text
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Kirsch, David G. “Using genetically engineered mice for radiation research.” Radiat Res 176, no. 3 (September 2011): 275–79. https://doi.org/10.1667/rrxx35.1.Full Text Link to Item
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Weidhaas, Joanne B., and David G. Kirsch. “The Holman Research Pathway in radiation oncology.” Int J Radiat Oncol Biol Phys 80, no. 2 (June 1, 2011): 321–23. https://doi.org/10.1016/j.ijrobp.2011.01.030.Full Text Link to Item
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Kirsch, D. G., J. Grimm, A. R. Guimaraes, and R. Weissleder. “In response to Dr. Garbow and colleagues.” International Journal of Radiation Oncology Biology Physics 79, no. 3 (March 1, 2011): 959. https://doi.org/10.1016/j.ijrobp.2010.10.046.Full Text
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Dodd, Rebecca D., Jeffery K. Mito, and David G. Kirsch. “Animal models of soft-tissue sarcoma.” Dis Model Mech 3, no. 9–10 (September 2010): 557–66. https://doi.org/10.1242/dmm.005223.Full Text Open Access Copy Link to Item
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Curtis, Stephen J., Kerstin W. Sinkevicius, Danan Li, Allison N. Lau, Rebecca R. Roach, Raffaella Zamponi, Amber E. Woolfenden, David G. Kirsch, Kwok-Kin Wong, and Carla F. Kim. “Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.” Cell Stem Cell 7, no. 1 (July 2, 2010): 127–33. https://doi.org/10.1016/j.stem.2010.05.021.Full Text Link to Item
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Kim, BoKyong, Yen-Lin E. Chen, David G. Kirsch, Saveli I. Goldberg, Wendy Kobayashi, Jong Hyun Kung, John A. Wolfgang, et al. “An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control.” Int J Radiat Oncol Biol Phys 77, no. 3 (July 1, 2010): 843–50. https://doi.org/10.1016/j.ijrobp.2009.06.086.Full Text Link to Item
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Yoon, Sam S., Yen-Lin Chen, David G. Kirsch, Ugwuji N. Maduekwe, Andrew E. Rosenberg, G Petur Nielsen, Dushyant V. Sahani, Edwin Choy, David C. Harmon, and Thomas F. DeLaney. “Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas.” Ann Surg Oncol 17, no. 6 (June 2010): 1515–29. https://doi.org/10.1245/s10434-010-0935-1.Full Text Link to Item
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Williams, Jacqueline P., Stephen L. Brown, George E. Georges, Martin Hauer-Jensen, Richard P. Hill, Amy K. Huser, David G. Kirsch, et al. “Animal models for medical countermeasures to radiation exposure.” Radiat Res 173, no. 4 (April 2010): 557–78. https://doi.org/10.1667/RR1880.1.Full Text Link to Item
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Kirsch, David G., Jan Grimm, Alexander R. Guimaraes, Gregory R. Wojtkiewicz, Bradford A. Perez, Philip M. Santiago, Nikolas K. Anthony, et al. “Imaging primary lung cancers in mice to study radiation biology.” Int J Radiat Oncol Biol Phys 76, no. 4 (March 15, 2010): 973–77. https://doi.org/10.1016/j.ijrobp.2009.11.038.Full Text Link to Item
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Johnston, S. M., B. A. Perez, D. G. Kirsch, and C. T. Badea. “Phase-selective image reconstruction of the lungs in small animals using Micro-CT.” Proc Spie Int Soc Opt Eng 7622 (February 15, 2010): 76223G.1-76223G.9. https://doi.org/10.1117/12.844359.Full Text Link to Item
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Kirsch, David G., Philip M. Santiago, Emmanuelle di Tomaso, Julie M. Sullivan, Wu-Shiun Hou, Talya Dayton, Laura B. Jeffords, et al. “p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.” Science 327, no. 5965 (January 29, 2010): 593–96. https://doi.org/10.1126/science.1166202.Full Text Link to Item
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Kumar, Madhu S., Ryan E. Pester, Cindy Y. Chen, Keara Lane, Christine Chin, Jun Lu, David G. Kirsch, Todd R. Golub, and Tyler Jacks. “Dicer1 functions as a haploinsufficient tumor suppressor.” Genes Dev 23, no. 23 (December 1, 2009): 2700–2704. https://doi.org/10.1101/gad.1848209.Full Text Link to Item
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Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” Plos One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.Full Text Link to Item
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Demyttenaere, Sebastian V., Peter Nau, Matthew Henn, Catherine Beck, Jeffrey Zaruby, Michael Primavera, David Kirsch, et al. “Barbed suture for gastrointestinal closure: a randomized control trial.” Surg Innov 16, no. 3 (September 2009): 237–42. https://doi.org/10.1177/1553350609342988.Full Text Link to Item
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Yoon, Sam S., Lars Stangenberg, Yoon-Jin Lee, Courtney Rothrock, Jonathan M. Dreyfuss, Kwan-Hyuck Baek, Peter R. Waterman, et al. “Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.” Int J Radiat Oncol Biol Phys 74, no. 4 (July 15, 2009): 1207–16. https://doi.org/10.1016/j.ijrobp.2009.02.052.Full Text Link to Item
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Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma.” Curr Treat Options Oncol 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.Full Text Link to Item
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Wagner, Timothy D., Wendy Kobayashi, Susan Dean, Saveli I. Goldberg, David G. Kirsch, Herman D. Suit, Francis J. Hornicek, et al. “Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone.” Int J Radiat Oncol Biol Phys 73, no. 1 (January 1, 2009): 259–66. https://doi.org/10.1016/j.ijrobp.2008.03.074.Full Text Link to Item
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Niedre, Mark J., Ruben H. de Kleine, Elena Aikawa, David G. Kirsch, Ralph Weissleder, and Vasilis Ntziachristos. “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.” Proc Natl Acad Sci U S A 105, no. 49 (December 9, 2008): 19126–31. https://doi.org/10.1073/pnas.0804798105.Full Text Link to Item
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Lin, Nancy U., Lisa A. Carey, Minetta C. Liu, Jerry Younger, Steven E. Come, Matthew Ewend, Gordon J. Harris, et al. “Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer.” J Clin Oncol 26, no. 12 (April 20, 2008): 1993–99. https://doi.org/10.1200/JCO.2007.12.3588.Full Text Link to Item
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Kirsch, David G., Daniela M. Dinulescu, John B. Miller, Jan Grimm, Philip M. Santiago, Nathan P. Young, G Petur Nielsen, et al. “A spatially and temporally restricted mouse model of soft tissue sarcoma.” Nat Med 13, no. 8 (August 2007): 992–97. https://doi.org/10.1038/nm1602.Full Text Link to Item
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Abraham, John A., Francis J. Hornicek, Adam M. Kaufman, David C. Harmon, Dempsey S. Springfield, Kevin A. Raskin, Henry J. Mankin, et al. “Treatment and outcome of 82 patients with angiosarcoma.” Ann Surg Oncol 14, no. 6 (June 2007): 1953–67. https://doi.org/10.1245/s10434-006-9335-y.Full Text Link to Item
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Delaney, Thomas F., Lucyna Kepka, Saveli I. Goldberg, Francis J. Hornicek, Mark C. Gebhardt, Sam S. Yoon, Dempsey S. Springfield, et al. “Radiation therapy for control of soft-tissue sarcomas resected with positive margins.” Int J Radiat Oncol Biol Phys 67, no. 5 (April 1, 2007): 1460–69. https://doi.org/10.1016/j.ijrobp.2006.11.035.Full Text Link to Item
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Ventura, Andrea, David G. Kirsch, Margaret E. McLaughlin, David A. Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E. Reczek, Ralph Weissleder, and Tyler Jacks. “Restoration of p53 function leads to tumour regression in vivo.” Nature 445, no. 7128 (February 8, 2007): 661–65. https://doi.org/10.1038/nature05541.Full Text Link to Item
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Chen, Y. -. B., S. Y. Seo, D. G. Kirsch, T. -. T. Sheu, W. -. C. Cheng, and J. M. Hardwick. “Alternate functions of viral regulators of cell death.” Cell Death Differ 13, no. 8 (August 2006): 1318–24. https://doi.org/10.1038/sj.cdd.4401964.Full Text Link to Item
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Grimm, Jan, David G. Kirsch, Stephen D. Windsor, Carla F Bender Kim, Philip M. Santiago, Vasilis Ntziachristos, Tyler Jacks, and Ralph Weissleder. “Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.” Proc Natl Acad Sci U S A 102, no. 40 (October 4, 2005): 14404–9. https://doi.org/10.1073/pnas.0503920102.Full Text Link to Item
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Kirsch, David G., David H. Ebb, Alvaro H. Hernandez, and Nancy J. Tarbell. “Proton radiotherapy for Hodgkin's disease in the sacrum.” Lancet Oncol 6, no. 7 (July 2005): 532–33. https://doi.org/10.1016/S1470-2045(05)70248-5.Full Text Link to Item
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Shaw, Alice T., David G. Kirsch, and Tyler Jacks. “Future of early detection of lung cancer: the role of mouse models.” Clin Cancer Res 11, no. 13 Pt 2 (July 1, 2005): 4999s-5003s. https://doi.org/10.1158/1078-0432.CCR-05-9005.Full Text Link to Item
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Kirsch, David G., and Jay S. Loeffler. “Brain metastases in patients with breast cancer: new horizons.” Clin Breast Cancer 6, no. 2 (June 2005): 115–24. https://doi.org/10.3816/CBC.2005.n.013.Full Text Link to Item
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Kirsch, David G., Carlos J. Ledezma, Christina S. Mathews, Atul K. Bhan, Marek Ancukiewicz, Fred H. Hochberg, and Jay S. Loeffler. “Survival after brain metastases from breast cancer in the trastuzumab era.” J Clin Oncol 23, no. 9 (March 20, 2005): 2114–16. https://doi.org/10.1200/JCO.2005.05.249.Full Text Link to Item
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Kim, C. F. B., E. L. Jackson, D. G. Kirsch, J. Grimm, A. T. Shaw, K. Lane, J. Kissil, et al. “Mouse models of human non-small-cell lung cancer: raising the bar.” Cold Spring Harb Symp Quant Biol 70 (2005): 241–50. https://doi.org/10.1101/sqb.2005.70.037.Full Text Link to Item
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Kirsch, David G., and Jay S. Loeffler. “Treating brain metastases: current approaches and future directions.” Expert Rev Neurother 4, no. 6 (November 2004): 1015–22. https://doi.org/10.1586/14737175.4.6.1015.Full Text Link to Item
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Kirsch, D. G., and J. S. Loeffler. “The controversy of adjuvant whole-brain radiation therapy.” Journal of Supportive Oncology 2, no. 5 (September 1, 2004): 412–14.
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Kirsch, David G., and Nancy J. Tarbell. “New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy.” Pediatr Blood Cancer 42, no. 5 (May 2004): 461–64. https://doi.org/10.1002/pbc.10471.Full Text Link to Item
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Kirsch, David G., and Nancy J. Tarbell. “Conformal radiation therapy for childhood CNS tumors.” Oncologist 9, no. 4 (2004): 442–50. https://doi.org/10.1634/theoncologist.9-4-442.Full Text Link to Item
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Kirsch, David G., and Fred H. Hochberg. “Targeting HER2 in brain metastases from breast cancer.” Clin Cancer Res 9, no. 15 (November 15, 2003): 5435–36.Link to Item
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Kouba, D. J., D. G. Kirsch, D. Mimouni, and C. H. Nousari. “Wegener's granulomatosis with cardiac involvement masquerading as Lyme disease.” Clin Exp Rheumatol 21, no. 5 (September 2003): 647–49.Link to Item
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Somme, S., J. A. Rodriguez, D. G. Kirsch, and D. C. Liu. “Laparoscopic versus open fundoplication in infants.” Surg Endosc 16, no. 1 (January 2002): 54–56. https://doi.org/10.1007/s00464-001-8147-1.Full Text Link to Item
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Kirsch, D. G., A. Doseff, B. N. Chau, D. S. Lim, N. C. de Souza-Pinto, R. Hansford, M. B. Kastan, Y. A. Lazebnik, and J. M. Hardwick. “Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.” J Biol Chem 274, no. 30 (July 23, 1999): 21155–61. https://doi.org/10.1074/jbc.274.30.21155.Full Text Link to Item
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Rhodes, N., T. D’Souza, C. D. Foster, Y. Ziv, D. G. Kirsch, Y. Shiloh, M. B. Kastan, P. H. Reinhart, and T. M. Gilmer. “Defective potassium currents in ataxia telangiectasia fibroblasts.” Genes Dev 12, no. 23 (December 1, 1998): 3686–92. https://doi.org/10.1101/gad.12.23.3686.Full Text Link to Item
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Kirsch, D. G., and M. B. Kastan. “Tumor-suppressor p53: implications for tumor development and prognosis.” J Clin Oncol 16, no. 9 (September 1998): 3158–68. https://doi.org/10.1200/JCO.1998.16.9.3158.Full Text Link to Item
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Lim, D. S., D. G. Kirsch, C. E. Canman, J. H. Ahn, Y. Ziv, L. S. Newman, R. B. Darnell, Y. Shiloh, and M. B. Kastan. “ATM binds to beta-adaptin in cytoplasmic vesicles.” Proc Natl Acad Sci U S A 95, no. 17 (August 18, 1998): 10146–51. https://doi.org/10.1073/pnas.95.17.10146.Full Text Link to Item
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Clem, R. J., E. H. Cheng, C. L. Karp, D. G. Kirsch, K. Ueno, A. Takahashi, M. B. Kastan, et al. “Modulation of cell death by Bcl-XL through caspase interaction.” Proc Natl Acad Sci U S A 95, no. 2 (January 20, 1998): 554–59. https://doi.org/10.1073/pnas.95.2.554.Full Text Link to Item
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Cheng, E. H., D. G. Kirsch, R. J. Clem, R. Ravi, M. B. Kastan, A. Bedi, K. Ueno, and J. M. Hardwick. “Conversion of Bcl-2 to a Bax-like death effector by caspases.” Science 278, no. 5345 (December 12, 1997): 1966–68. https://doi.org/10.1126/science.278.5345.1966.Full Text Link to Item
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Kastan, M. B., S. E. Morgan, J. Siliciano, D. Kirsch, P. Dennis, and C. E. Canman. “Cell cycle and cell death after DNA damaye.” Faseb Journal 11, no. 9 (December 1, 1997).
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Agani, F., D. G. Kirsch, S. L. Friedman, M. B. Kastan, and G. L. Semenza. “p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.” Cancer Res 57, no. 20 (October 15, 1997): 4474–77.Link to Item
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Rosmarin, A. G., D. G. Caprio, D. G. Kirsch, H. Handa, and C. P. Simkevich. “GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription.” J Biol Chem 270, no. 40 (October 6, 1995): 23627–33. https://doi.org/10.1074/jbc.270.40.23627.Full Text Link to Item
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Smidt, C. R., D. Bean-Knudsen, D. G. Kirsch, and R. B. Rucker. “Does the intestinal microflora synthesize pyrroloquinoline quinone?” Biofactors 3, no. 1 (January 1991): 53–59.Link to Item
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Macy, J. M., T. A. Michel, and D. G. Kirsch. “Selenate reduction by a Pseudomonas species: a new mode of anaerobic respiration.” Fems Microbiol Lett 52, no. 1–2 (October 1, 1989): 195–98. https://doi.org/10.1016/0378-1097(89)90195-x.Full Text Link to Item
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Shull, L. R., D. G. Kirsch, C. L. Lohse, and J. A. Wisniewski. “Application of isolated hepatocytes to studies of drug metabolism in large food animals.” Xenobiotica 17, no. 3 (March 1987): 345–63. https://doi.org/10.3109/00498258709043944.Full Text Link to Item
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Shull, L. R., D. G. Kirsch, C. L. Lohse, G. P. Carlson, L. A. Doody, and J. A. Wisniewski. “Xenobiotic metabolism in suspensions and primary cultures of isolated hepatocytes prepared from the caudate process of bovine liver.” Am J Vet Res 47, no. 9 (September 1986): 2043–52.Link to Item
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Book Sections
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Floyd, W., H. C. Kuo, J. E. Himes, R. Patel, and D. G. Kirsch. “Genetically engineered mouse models for studying radiation biology and radiosensitizers.” In Cancer Drug Discovery and Development, 161–90, 2020. https://doi.org/10.1007/978-3-030-49701-9_8.Full Text
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Singer, S., W. D. Tap, D. G. Kirsch, and A. M. Crago. “Soft tissue sarcoma.” In DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology, 1401–50, 2018.
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Palta, M., C. L. Lee, S. W. Yusuf, and D. G. Kirsch. “Radiation therapy and cardiotoxicity.” In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 161–74, 2017. https://doi.org/10.1007/978-3-319-43096-6_7.Full Text
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Other Articles
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Brown, J. Q., L. Dodd, J. Geradts, Z. Harmany, S. Kennedy, Y. Kim, David Guy Kirsch, et al. “Data set for "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Application to the detection of residual disease in tumor margins",” March 12, 2013.Open Access Copy
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Conference Papers
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Inoue, Kazuki, Zhonghao Deng, Yufan Chen, Gregory Vitone, Eugenia Giannopoulou, Ren Xu, Shiaoching Gong, et al. “A novel regulatory network mediated by the miR182-PKR-IFN-beta axis plays a key role in osteoclastogenesis and osteoprotection.” In Journal of Bone and Mineral Research, 33:18–18. WILEY, 2018.Link to Item
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Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR/Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.” In Clinical Cancer Research, 24:44–45. AMER ASSOC CANCER RESEARCH, 2018.Link to Item
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Kirsch, David G. “Injury promotes sarcomagenesis.” In Clinical Cancer Research, 24:25–25. AMER ASSOC CANCER RESEARCH, 2018.Link to Item
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Brownstein, J. M., A. Rusek, K. C. Castle, Y. M. Mowery, A. J. Wisdom, N. T. Williams, L. Luo, R. Rosselot, and D. G. Kirsch. “High LET Carbon Ion Radiation Therapy in the Treatment of a Primary Mouse Sarcoma Model at the NASA Space Radiation Laboratory.” In International Journal of Radiation Oncology*Biology*Physics, 99:E581–E581. Elsevier BV, 2017. https://doi.org/10.1016/j.ijrobp.2017.06.1998.Full Text
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Huang, Jianguo, Mark Chen, Melodi J. Whitley, Hsuan-Cheng Kuo, Andrea Walens, Yvonne M. Mowery, David V. Mater, et al. “Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice.” In Tumor Biology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-2810.Full Text
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Kodra, J., D. Miles, S. W. Yoon, D. G. Kirsch, and M. Oldham. “Characterization of novel preclinical dose distributions for micro irradiator.” In Journal of Physics: Conference Series, Vol. 847, 2017. https://doi.org/10.1088/1742-6596/847/1/012054.Full Text
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Yoon, S. W., D. Miles, C. Cramer, M. Reinsvold, D. Kirsch, and M. Oldham. “Treatment planning and 3D dose verification of whole brain radiation therapy with hippocampal avoidance in rats.” In Journal of Physics: Conference Series, Vol. 847, 2017. https://doi.org/10.1088/1742-6596/847/1/012004.Full Text
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Wang, Dian, Jonathan Harris, William G. Kraybill, Burton Larry Eisenberg, David G. Kirsch, John Michael Kane, David S. Ettinger, et al. “Pathologic complete response and survival outcomes in patients with localized soft tissue sarcoma treated with neoadjuvant chemoradiotherapy or radiotherapy: Long-term update of NRG Oncology RTOG 9514 and 0630.” In Journal of Clinical Oncology, 35:11012–11012. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.11012.Full Text
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Kent, C. L., Y. M. Mowery, A. J. Wisdom, D. Van Mater, K. D. Castle, A. Reddy, S. S. Dave, and D. G. Kirsch. “Immune Checkpoint Inhibition and Radiation Therapy in 2 Primary Mouse Models of Soft Tissue Sarcoma: Impact of Tumor Mutational Load.” In International Journal of Radiation Oncology Biology Physics, 96:E578–79, 2016.Link to Item
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Nussbaum, D. P., C. N. Rushing, W. O. Lane, D. M. Cardona, D. G. Kirsch, B. L. Peterson, and D. Blazer. “Radiation Therapy is Associated with Improved Survival for Retroperitoneal Sarcoma: A Contemporary Analysis of 9,068 Patients.” In Annals of Surgical Oncology, 23:S38–39. SPRINGER, 2016.Link to Item
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Ashton, J. R., J. Hoye, K. Deland, M. Whitley, Y. Qi, E. Moding, D. G. Kirsch, J. West, and C. T. Badea. “A dual energy CT study on vascular effects of gold nanoparticles in radiation therapy.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 9788, 2016. https://doi.org/10.1117/12.2217012.Full Text
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Neff’, F., D. G. Kirsch, D. Saur, R. M. Schmid, A. Bazhin, M. F. Heikenwaelder, and J. T. Siveke. “Targeting notch for myeloid reprogramming in pancreatic cancer.” In Oncology Research and Treatment, 39:16–16. KARGER, 2016.Link to Item
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Robinson, T. J., M. Zhang, and D. G. Kirsch. “Next Generation Sequencing of Sarcoma Cells With HIF-1α Deletion Reveals Context-Dependent Regulation of HIF-1 Transcriptional Targets Induced by Radiation Versus Hypoxia.” In International Journal of Radiation Oncology*Biology*Physics, 93:S186–S186. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.445.Full Text
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Torok, J., K. D. Castle, M. Reinsvold, and D. G. Kirsch. “Modulation of Endothelial Cell Radiation Sensitivity and Lung Tumor Response to Radiation Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 93:E546–E546. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.1946.Full Text
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Whitley, Melodi J., Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, et al. “Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents.” In Molecular and Cellular Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-sy36-03.Full Text
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Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.Link to Item
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Clark, D. P., C. L. Lee, D. G. Kirsch, and C. T. Badea. “Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 9412, 2015. https://doi.org/10.1117/12.2081379.Full Text
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Eisinger-Mathason, TS Karin, Minsi Zhang, Qiu Qiong, Nicolas Skuli, Michael S. Nakazawa, Tatiana Karakasheva, Vera Mucaj, et al. “Abstract A41: Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.” In Translational and Therapeutic Potential of the Tumor Microenvironment. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.chtme14-a41.Full Text
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Moding, Everett J., Chang-Lung Lee, Katherine D. Castle, Patrick Oh, and David G. Kirsch. “Abstract LB-167: Tumor cells, but not endothelial cells, mediate the eradication of primary cancers by radiation therapy.” In Clinical Research (Excluding Clinical Trials). American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-lb-167.Full Text
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Yoon, Changhwan, Hae-June Lee, Do Joong Park, William D. Tap, TS Karin Eisinger-Mathason, David G. Kirsch, M Celeste Simon, and Sam S. Yoon. “Abstract 5447: Targeting vascular endothelial growth factor A and tumor hypoxia combined with radiation eradicates sarcomas through destruction of tumor vasculature and thwarting of the hypoxic response.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-5447.Full Text
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Li, A., X. Chen, Q. Zhang, D. G. Kirsch, I. Petersen, T. DeLaney, C. Freeman, A. Trotti, Y. J. Hitchcock, and D. Wang. “A Comparison of 6 IGRT Modalities Used for Soft-Tissue Sarcoma of the Extremity in RTOG 0630.” In International Journal of Radiation Oncology*Biology*Physics, 90:S831–32. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.2391.Full Text
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Moding, E., C. Lee, K. D. Castle, P. Oh, and D. G. Kirsch. “Dual Recombinase Technology Defines a Therapeutic Window for ATM Inhibitors to Selectively Radiosensitize Tumors.” In International Journal of Radiation Oncology*Biology*Physics, 90:S35–S35. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.147.Full Text
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Moding, E., C. Lee, K. D. Castle, P. Oh, and D. G. Kirsch. “Using Mouse Genetics to Dissect the Radiobiology of SBRT: Tumor Cells, Not Endothelial Cells, Regulate Local Control.” In International Journal of Radiation Oncology*Biology*Physics, 90:S56–S56. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.197.Full Text
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Perez, B. A., P. Mettu, L. Vajzovic, A. Alkaissi, B. A. Steffey, J. Cai, S. Stinnett, P. Mruthyunjaya, and D. G. Kirsch. “Uveal Melanoma Treated With Iodine-125 Episcleral Plaque According to the COMS Trial Is Associated With Worsened Visual Acuity Change and Increased Risk of Chronic Toxicity Compared to Lower Prescription Doses.” In International Journal of Radiation Oncology*Biology*Physics, 90:S306–S306. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.1023.Full Text
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Zhang, M., Q. Qiu, H. Min, Z. Li, D. Cardona, Y. Ma, A. Nichols, et al. “HIF-1α Regulates Radiation Resistance in Primary Sarcomas in a Tumor-Cell Autonomous Mechanism.” In International Journal of Radiation Oncology*Biology*Physics, 90:S772–S772. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.2235.Full Text
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Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.Full Text
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Nussbaum, D. P., P. J. Speicher, A. M. Ganapathi, J. E. Keenan, D. G. Kirsch, D. S. Tyler, and D. G. Blazer. “Neoadjuvant Radiation does not Increase Morbidity following Resection of Retroperitoneal Sarcoma.” In Annals of Surgical Oncology, 21:S143–44. SPRINGER, 2014.Link to Item
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Oldham, M., J. Newton, L. Rankine, J. Adamovics, D. Kirsch, and S. Das. “How accurate is image guided radiation therapy (IGRT) delivered with a micro-irradiator?” In J Phys Conf Ser, 444:12070, 2013. https://doi.org/10.1088/1742-6596/444/1/012070.Full Text Link to Item
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Perez, B., L. Vajzovic, P. Mettu, D. Rivera, A. Alkaissi, B. A. Steffey, S. Stinnett, L. B. Marks, P. Mruthyunjaya, and D. G. Kirsch. “Evaluating the Relationship Between Prescription Dose and Overall Survival Among Patients Treated With I-125 Brachytherapy for Posterior Uveal Melanoma.” In International Journal of Radiation Oncology*Biology*Physics, 84:S197–S197. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.511.Full Text
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Washington, I., C. Lee, E. J. Moding, Y. Li, L. Mao, Y. Kim, H. A. Rockman, and D. G. Kirsch. “p21 Functions to Prevent Radiation-induced Myocardial Injury in Mice.” In International Journal of Radiation Oncology*Biology*Physics, 84:S673–S673. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.1798.Full Text
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Newton, J., Y. Li, J. Adamovics, D. Kirsch, S. Das, and M. Oldham. “Identification of a Targeting Error in a Small Field Biological Irradiator Using 3D Dosimetry Techniques.” In Medical Physics, 39:3898–3898, 2012. https://doi.org/10.1118/1.4735914.Full Text Link to Item
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Doan, P. L., J. L. Russell, H. A. Himburg, K. Helms, J. M. Sullivan, L. B. Jeffords, N. J. Chao, D. G. Kirsch, and J. P. Chute. “Egf Signaling Regulates Hematopoietic Regeneration Following Total Body Irradiation.” In Biology of Blood and Marrow Transplantation, 18:S235–S235. Elsevier BV, 2012. https://doi.org/10.1016/j.bbmt.2011.12.497.Full Text
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Wang, D., Q. Zhang, D. G. Kirsch, S. Okuno, J. Kane, X. Li, D. Roberge, S. E. Finkelstein, T. DeLaney, and B. Eisenberg. “RTOG Phase II Trial of Preoperative Image Guided Radiotherapy (IG-RT) For Primary Soft Tissue Sarcoma of the Extremity: Acute Toxicity Report.” In International Journal of Radiation Oncology*Biology*Physics, 81:S117–S117. Elsevier BV, 2011. https://doi.org/10.1016/j.ijrobp.2011.06.239.Full Text
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Doan, P. L., J. L. Russell, H. A. Himburg, K. Helms, S. K. Meadows, P. Daher, J. M. Sullivan, et al. “Tie2+ Endothelial Cells Mediate Hematopoietic Stem Cell Regeneration Via EGF Signaling.” In Biology of Blood and Marrow Transplantation, 17:S188–S188. Elsevier BV, 2011. https://doi.org/10.1016/j.bbmt.2010.12.107.Full Text
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Doan, Phuong L., J Lauren Russell, Heather A. Himburg, Sarah K. Meadows, Pamela Daher, Katherine Helms, Mamle Quarmyne, et al. “Facilitation of Hematopoietic Reconstitution Via Inhibition of Bone Marrow Endothelial Cell-Mediated SDF-1 Signaling.” In Blood, 116:1578–1578. AMER SOC HEMATOLOGY, 2010.Link to Item
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DeLaney, T. F., W. R. Bosch, D. Roberge, S. E. Finkelstein, I. A. Petersen, M. G. Haddock, Y. E. Chen, N. G. Saito, D. G. Kirsch, and D. Wang. “RTOG Sarcoma Radiation Oncologists Reach Consensus on Gross Tumor Volume (GTV) and Clinical Target Volume (CTV) on Computed Tomography Images for Preoperative Radiotherapy of Primary Soft Tissue Sarcoma of Extremity in RTOG Studies.” In International Journal of Radiation Oncology*Biology*Physics, 78:S87–S87. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.233.Full Text
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Doan, Phuong L., J Lauren Russell, Sarah K. Meadows, Heather A. Himburg, Pamela Daher, Nelson J. Chao, David G. Kirsch, and John P. Chute. “Tie2+Bone Marrow Endothelial Cells Regulate Hematopoietic Reconstitution In Vivo.” In Blood, 114:106–106. AMER SOC HEMATOLOGY, 2009.Link to Item
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Doan, Phuono L., J Lauren Russell, Sarah K. Meadows, Heather A. Himburg, Pamela Daher, Nelson J. Chao, David G. Kirsch, and John P. Chute. “Deletion of Bak and Bax in Tie2+BM Hematopoietic Stem Cells Induces a B Cell Lymphoproliferative Disorder.” In Blood, 114:513–513. AMER SOC HEMATOLOGY, 2009.Link to Item
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DeLaney, T. F., B. Kim, Y. E. Chen, D. G. Kirsch, S. I. Goldberg, W. Kobayashi, J. H. Kung, K. Doppke, A. E. Rosenberg, and F. J. Hornicek. “An Effective 3D Target Volume for Preoperative Radiotherapy in Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control.” In International Journal of Radiation Oncology*Biology*Physics, 75:S527–28. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.1204.Full Text
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Ghafoori, A., C. Lee, B. Perez, S. Johnston, R. Rodrigues, C. Badea, Y. Kim, S. Lowe, and D. G. Kirsch. “In Vivo shRNA to Study the Molecular Mechanisms of Radiation Response of Primary Cancers in Mice.” In International Journal of Radiation Oncology*Biology*Physics, 75:S171–72. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.401.Full Text
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Perez, B. A., A. P. Ghafoori, S. M. Johnston, L. B. Jeffords, Y. Kim, C. T. Badea, G. A. Johnson, and D. G. Kirsch. “Dissecting the Mechanism of Tumor Response to Radiation Therapy with Primary Lung Cancers in Mice.” In International Journal of Radiation Oncology*Biology*Physics, 75:S537–S537. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.1227.Full Text
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Wagner, T. D., W. Kobayashi, S. Dean, S. I. Goldberg, D. G. Kirsch, H. D. Suit, F. J. Hornicek, D. S. Springfield, S. S. Yoon, and T. F. DeLaney. “Combination Short-course, Preoperative Irradiation, Surgical Resection and Reduced-field, High-dose, Postoperative Irradiation in the Treatment of Tumors Involving the Bone.” In International Journal of Radiation Oncology*Biology*Physics, 72:S503–4. Elsevier BV, 2008. https://doi.org/10.1016/j.ijrobp.2008.06.1470.Full Text
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Datasets
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Fu, Henry L., Jenna L. Mueller, Melodi J. Whitley, Diana M. Cardona, Rebecca M. Willett, David G. Kirsch, J Quincy Brown, and Nimmi Ramanujam. “Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma.,” 2016. https://doi.org/10.1371/journal.pone.0147006.Data Access Open Access Copy Link to Item
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Mueller, J., Z. Harmany, J. Mito, S. Kennedy, Y. Kim, L. Dodd, J. Geradts, et al. “Data set for "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Application to the detection of residual disease in tumor margins",” March 12, 2013.Open Access Copy
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- Teaching & Mentoring
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Recent Courses
- PHARM 393: Research Independent Study 2021
- PHARM 394: Research Independent Study 2021
- PHARM 493: Research Independent Study 2021
- PHARM 494: Research Independent Study 2021
- PHARM 393: Research Independent Study 2020
- PHARM 394: Research Independent Study 2020
- PHARM 493: Research Independent Study 2020
- PHARM 494: Research Independent Study 2020
- PHARM 393: Research Independent Study 2019
- PHARM 394: Research Independent Study 2019
- PHARM 493: Research Independent Study 2019
- PHARM 494: Research Independent Study 2019
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