David Guy Kirsch | Scholars@Duke

David Guy Kirsch
Barbara Levine University Professor

My clinical interests are the multi-modality care of patients with bone and soft tissue sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing mouse models of cancer to study cancer and radiation biology in order to develop new cancer therapies in the pre-clinical setting.

Current Appointments & Affiliations

Barbara Levine University Professor, Radiation Oncology, Clinical Science Departments 2016
Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

Duke Box 91006, Durham, NC 27708
LSRC Building, Room B327, Durham, NC 27710
david.kirsch@duke.edu (919) 681-8586

Background
Education, Training, & Certifications
- M.D., Johns Hopkins University School of Medicine 2000
- Ph.D., Johns Hopkins University School of Medicine 2000
Duke Appointment History
- Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012 - 2015
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2012 - 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007 - 2012
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2008 - 2012
- Assistant Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2008
Recognition
In the News
- MAY 5, 2016
  
  Duke Awards Distinguished Professorships, Inducts New Bass Society Members
- MAR 18, 2016
  
  Cancer Research David Kirsch Receives NCI Outstanding Investigator Award
- JAN 8, 2016 CBS News
  
  New imaging technique ‘lights up’ cancer cells
- JAN 7, 2016 The Daily Mail
  
  New injection illuminates cancer cells, 'making it easier for surgeons to locate and remove tumors’
- JAN 7, 2016 TIME
  
  Researchers find a way to light up cancer cells
- JAN 6, 2016
  
  Early Trial Shows Injectable Agent Illuminates Cancer During Surgery
- AUG 1, 2013 WRAL.com
  
  Komen grants $3.6 million to Duke, UNC breast cancer research
Research
Selected Grants
- Advancing Cancer Therapy through Ground Breaking Research in Radiation Biology awarded by National Institutes of Health 2016 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Evaluation of kinase inhibitors awarded by XRAD THERAPEUTICS, INC. 2016 - 2021
- Awakening the dormant tumor: the role of the tumor microenvironment in breast cancer recurrence awarded by National Institutes of Health 2017 - 2021
- Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance awarded by National Institutes of Health 2017 - 2021
- Dissecting the role of the immune system in the radiation response of Kras-mutant tumors awarded by National Institutes of Health 2017 - 2021
- Using CRISPR/Cas9 to dissect the role of FUS-CHOP in tumor response to radiation therapy awarded by National Institutes of Health 2016 - 2020
- Pembroluzimab and Radiation Therapy to Improve Outcome in Localized High-Risk Sarcoma awarded by Association of American Cancer Institutes 2017 - 2020
- Targeting the Hippo pathway in Ras-driven rhabdomyosarcoma awarded by V Foundation for Cancer Research 2016 - 2019
- Role of ErbB Receptor Signaling in Regulating Normal and Leukemic Stem Cell Fate awarded by National Institutes of Health 2014 - 2019
- Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus awarded by National Institutes of Health 2016 - 2018
- Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2015 - 2018
- Radiosensitization of brainstem gliomas by targeting ATM awarded by St. Baldrick's Foundation 2017 - 2018
- Dissecting the Mechanisms of Immune Mediated Radiation Resistance in Sarcomas awarded by Sarcoma Foundation of America 2017 - 2018
- An Activatable Nanoparticle Probe for Molecular Imaging of Protease Activity by Dual Energy CT awarded by National Institutes of Health 2015 - 2018
- Non-Canonical Responses to DNA damage in Drosophila Polyploid Cells awarded by National Institutes of Health 2015 - 2018
- The role of MST1 in non-canonical Hippo signaling in rhabdomyosarcoma awarded by Alex's Lemonade Stand 2015 - 2018
- Defining the role of miR-182 in HZE-induced tumorignesis awarded by National Aeronautics and Space Administration 2014 - 2018
- Clinical Trials Umbrella - Scanned Beam awarded by Massachusetts General Hospital 2016 - 2017
- A novel therapeutic target for radiation-induced hematological malignancies: calcium calmodulin kinase kinase 2 awarded by Department of Defense 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Mechanisms that Regulate Sarcoma Response to Immune Checkpoint Inhibition of PD-1 awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Mechanisms that Regulate Sarcoma Response to Immune Checkpoint Inhibition of PD-1 awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Gertrude B Elion Award - Amy Wisdom awarded by Triangle Community Foundation 2016 - 2017
- Training Grant in Radiation Biology awarded by Vanderbilt University 2016 - 2017
- Testing current and developing novel therapies for NF1-mutant sarcomas in a genetically engineered mouse model awarded by Department of Defense 2014 - 2017
- Janssen Research AGreement awarded by Janssen Research & Development, LLC 2014 - 2016
- Skeletal Muscle and Vascular Remodeling in Peripheral Artery Disease awarded by National Institutes of Health 2014 - 2016
- Muscle-Resident Stem Cells for Angiogenesis and Vascular Maturation in PAD awarded by National Institutes of Health 2013 - 2016
- Intraoperative detection and ablation of microscopic residual cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Independent Scientist Award for Radiation Research awarded by National Institutes of Health 2011 - 2016
- Duke NSCOR: Lung Cancer Risk from HZE Ions awarded by National Aeronautics and Space Administration 2011 - 2016
- Radiation Therapy: Dissecting the Role of Stromal Cells in Tumor Control awarded by National Institutes of Health 2013 - 2016
- Defining the Cellular Target of Radiation Therapy awarded by National Institutes of Health 2014 - 2015
- Evaluating GSK2126458 with radiation therapy in pre-clinical models awarded by GlaxoSmithKline 2013 - 2015
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Modulation of Endothelial Cell Radiation Sensitivity and Lung Tumor Response to Radiation Therapy awarded by Rsna Research & Education Fund 2014 - 2015
- Dissecting the roles of HIF-1a and HIF-2a in tumor response to radiation therapy awarded by National Institutes of Health 2013 - 2015
- Defining the cellular target of radiotherapy in primary mouse models of cancer awarded by National Institutes of Health 2013 - 2015
- SARC Sarcoma SPORE - Developmental Research Program awarded by Sarcoma Alliance for Research Through Collaboration 2013 - 2015
- Engineered imaging nanoparticles for real-time detection of cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2015
- Dissecting Mechanisms of Metastasis Through Comparative Systems Genetics awarded by National Institutes of Health 2008 - 2013
- Mechanisms of Late Effects of Exposure to Radiation awarded by National Institutes of Health 2008 - 2013
- A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment awarded by National Institutes of Health 2011 - 2013
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Image-Guided Radiation Therapy and Radiosurgery for Small Animals awarded by National Institutes of Health 2009 - 2011
- Intravital point-scanning confocal microscope awarded by National Institutes of Health 2010 - 2011
- Imaging Lung Cancer in Mice to Improve Radiation Therapy awarded by National Institutes of Health 2005 - 2010
- Dissecting Mechanism of GI Syndrome to Restore Function after Radiation Exposure awarded by National Institutes of Health 2007 - 2010
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Ashton, JR, Hoye, J, Deland, K, Whitley, M, Qi, Y, Moding, E, Kirsch, DG, West, J, and Badea, CT. "A dual energy CT study on vascular effects of gold nanoparticles in radiation therapy." January 1, 2016. Full Text
  - Clark, DP, Lee, CL, Kirsch, DG, and Badea, CT. "Rank-sparsity constrained, spectro-temporal reconstruction for retrospectively gated, dynamic CT." January 1, 2015. Full Text
  - Oldham, M, Newton, J, Rankine, L, Adamovics, J, Kirsch, D, and Das, S. "How accurate is image guided radiation therapy (IGRT) delivered with a micro-irradiator?." January 2013. Full Text
  - Newton, J, Li, Y, Adamovics, J, Kirsch, D, Das, S, and Oldham, M. "TU-C-BRB-02: Identification of a Targeting Error in a Small Field Biological Irradiator Using 3D Dosimetry Techniques." June 2012. Full Text
- Datasets
  - Fu, HL, Mueller, JL, Whitley, MJ, Cardona, DM, Willett, RM, Kirsch, DG, Brown, JQ, and Ramanujam, N. "Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma." (January 22, 2016). Full Text Open Access Copy
- Journal Articles
  - Dodd, RD, Lee, C-L, Overton, T, Huang, W, Eward, WC, Luo, L, Ma, Y, Ingram, DR, Torres, KE, Cardona, DM, Lazar, A, and Kirsch, DG. "NF1+/- hematopoietic cells accelerate malignant peripheral nerve sheath tumor development without altering chemotherapy response." Cancer research (June 23, 2017). Full Text
  - McConnell, AM, Yao, C, Yeckes, AR, Wang, Y, Selvaggio, AS, Tang, J, Kirsch, DG, and Stripp, BR. "p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway." Cell reports 17, no. 9 (November 2016): 2173-2182. Full Text
  - Larrier, NA, Czito, BG, and Kirsch, DG. "Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy." Surgical oncology clinics of North America 25, no. 4 (October 2016): 841-860. (Review) Full Text
  - McConnell, AM, Konda, B, Kirsch, DG, and Stripp, BR. "Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation." Scientific reports 6 (September 23, 2016): 33455-. Full Text
  - Chitalia, R, Mueller, J, Fu, HL, Whitley, MJ, Kirsch, DG, Brown, JQ, Willett, R, and Ramanujam, N. "Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes." Biomedical optics express 7, no. 9 (September 2016): 3412-3424. Full Text
  - Bartholf DeWitt, S, Eward, WC, Eward, CA, Lazarides, AL, Whitley, MJ, Ferrer, JM, Brigman, BE, Kirsch, DG, and Berg, J. "A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs." Veterinary surgery : VS 45, no. 6 (August 2016): 715-722. Full Text
  - Coleman, CN, Higgins, GS, Brown, JM, Baumann, M, Kirsch, DG, Willers, H, Prasanna, PGS, Dewhirst, MW, Bernhard, EJ, and Ahmed, MM. "Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials." Clinical cancer research : an official journal of the American Association for Cancer Research 22, no. 13 (July 2016): 3138-3147. (Review) Full Text
  - Li, XA, Chen, X, Zhang, Q, Kirsch, DG, Petersen, I, DeLaney, TF, Freeman, CR, Trotti, A, Hitchcock, Y, Bedi, M, Haddock, M, Salerno, K, Dundas, G, and Wang, D. "Margin reduction from image guided radiation therapy for soft tissue sarcoma: Secondary analysis of Radiation Therapy Oncology Group 0630 results." Practical radiation oncology 6, no. 4 (July 2016): e135-e140. Full Text
  - Moding, EJ, Mowery, YM, and Kirsch, DG. "Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era." Cancer journal (Sudbury, Mass.) 22, no. 4 (July 2016): 267-273. Full Text
  - Nussbaum, DP, Rushing, CN, Lane, WO, Cardona, DM, Kirsch, DG, Peterson, BL, and Blazer, DG. "Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database." The Lancet. Oncology 17, no. 7 (July 2016): 966-975. Full Text
  - Whitley, MJ, Cardones, AR, Craciunescu, OI, and Kirsch, DG. "Externally applied high-dose-rate brachytherapy for deeply invasive cutaneous squamous cell carcinoma in an older patient." Practical radiation oncology 6, no. 4 (July 2016): e141-e144. Full Text
  - Kim, K-T, Lee, HW, Lee, H-O, Song, HJ, Jeong, DE, Shin, S, Kim, H, Shin, Y, Nam, D-H, Jeong, BC, Kirsch, DG, Joo, KM, and Park, W-Y. "Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma." Genome biology 17 (April 29, 2016): 80-. Full Text
  - Dodd, RD, Sachdeva, M, Mito, JK, Eward, WC, Brigman, BE, Ma, Y, Dodd, L, Kim, Y, Lev, D, and Kirsch, DG. "Myogenic transcription factors regulate pro-metastatic miR-182." Oncogene 35, no. 14 (April 2016): 1868-1875. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." Journal of Clinical Investigation 126, no. 4 (April 1, 2016): 1606-1606. Full Text
  - Lazarides, AL, Whitley, MJ, Strasfeld, DB, Cardona, DM, Ferrer, JM, Mueller, JL, Fu, HL, Bartholf DeWitt, S, Brigman, BE, Ramanujam, N, Kirsch, DG, and Eward, WC. "A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma." Theranostics 6, no. 2 (January 2016): 155-166. Full Text Open Access Copy
  - Oldham, M, Yoon, P, Fathi, Z, Beyer, WF, Adamson, J, Liu, L, Alcorta, D, Xia, W, Osada, T, Liu, C, Yang, XY, Dodd, RD, Herndon, JE, Meng, B, Kirsch, DG, Lyerly, HK, Dewhirst, MW, Fecci, P, Walder, H, and Spector, NL. "X-Ray Psoralen Activated Cancer Therapy (X-PACT)." PloS one 11, no. 9 (January 2016): e0162078-. Full Text Open Access Copy
  - Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, C-L, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O'Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer." Science translational medicine 8, no. 320 (January 2016): 320ra4-. Full Text
  - Sachdeva, M, Dodd, RD, Huang, Z, Grenier, C, Ma, Y, Lev, DC, Cardona, DM, Murphy, SK, and Kirsch, DG. "Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182." Cancer letters 369, no. 1 (December 2015): 202-211. Full Text
  - Clark, DP, Lee, C-L, Kirsch, DG, and Badea, CT. "Spectrotemporal CT data acquisition and reconstruction at low dose." Medical physics 42, no. 11 (November 2015): 6317-6336. Full Text Open Access Copy
  - Mueller, JL, Fu, HL, Mito, JK, Whitley, MJ, Chitalia, R, Erkanli, A, Dodd, L, Cardona, DM, Geradts, J, Willett, RM, Kirsch, DG, and Ramanujam, N. "A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins." International journal of cancer 137, no. 10 (November 2015): 2403-2412. Full Text
  - Kirsch, DG. "Biomarkers for Predicting Radiation Response." Seminars in radiation oncology 25, no. 4 (October 2015): 225-226. Full Text
  - Whitley, MJ, Weissleder, R, and Kirsch, DG. "Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer." Seminars in radiation oncology 25, no. 4 (October 2015): 313-321. (Review) Full Text
  - Lee, C-L, Castle, KD, Moding, EJ, Blum, JM, Williams, N, Luo, L, Ma, Y, Borst, LB, Kim, Y, and Kirsch, DG. "Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma." Nature communications 6 (September 24, 2015): 8477-. Full Text
  - Brown, JM, Wouters, BG, and Kirsch, DG. "Cell Death Identification in Anticancer Therapy-Letter." Cancer research 75, no. 17 (September 2015): 3681-. (Letter) Full Text
  - Hou, C-H, Lazarides, AL, Speicher, PJ, Nussbaum, DP, Blazer, DG, Kirsch, DG, Brigman, BE, and Eward, WC. "The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival." Annals of surgical oncology 22, no. 9 (September 2015): 2831-2838. Full Text
  - Lane, WO, Cramer, CK, Nussbaum, DP, Speicher, PJ, Gulack, BC, Czito, BG, Kirsch, DG, Tyler, DS, and Blazer, DG. "Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma." Journal of surgical oncology 112, no. 4 (September 2015): 352-358. Full Text
  - Sachdeva, M, Whitley, MJ, Mito, JK, Ma, Y, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma." Disease Models & Mechanisms 8, no. 9 (September 1, 2015): 1169-1169. Full Text
  - Zhang, M, and Kirsch, DG. "The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis." Disease models & mechanisms 8, no. 9 (September 2015): 1155-1166. Full Text
  - Sachdeva, M, Whitley, MJ, Mito, JK, Ma, Y, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma." Disease models & mechanisms 8, no. 8 (August 2015): 867-875. Full Text
  - Barcellos-Hoff, MH, Blakely, EA, Burma, S, Fornace, AJ, Gerson, S, Hlatky, L, Kirsch, DG, Luderer, U, Shay, J, Wang, Y, and Weil, MM. "Concepts and challenges in cancer risk prediction for the space radiation environment." Life sciences in space research 6 (July 17, 2015): 92-103. (Review) Full Text
  - Baldini, EH, Wang, D, Haas, RLM, Catton, CN, Indelicato, DJ, Kirsch, DG, Roberge, D, Salerno, K, Deville, C, Guadagnolo, BA, O'Sullivan, B, Petersen, IA, Le Pechoux, C, Abrams, RA, and DeLaney, TF. "Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel." International journal of radiation oncology, biology, physics 92, no. 3 (July 2015): 602-612. (Review) Full Text
  - Nussbaum, DP, Speicher, PJ, Gulack, BC, Ganapathi, AM, Englum, BR, Kirsch, DG, Tyler, DS, and Blazer, DG. "Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas." Annals of surgery 262, no. 1 (July 2015): 163-170. Full Text
  - Wang, D, Zhang, Q, Eisenberg, BL, Kane, JM, Li, XA, Lucas, D, Petersen, IA, DeLaney, TF, Freeman, CR, Finkelstein, SE, Hitchcock, YJ, Bedi, M, Singh, AK, Dundas, G, and Kirsch, DG. "Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33, no. 20 (July 2015): 2231-2238. Full Text
  - Zhang, M, Qiu, Q, Li, Z, Sachdeva, M, Min, H, Cardona, DM, DeLaney, TF, Han, T, Ma, Y, Luo, L, Ilkayeva, OR, Lui, K, Nichols, AG, Newgard, CB, Kastan, MB, Rathmell, JC, Dewhirst, MW, and Kirsch, DG. "HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism." Radiation research 183, no. 6 (June 2015): 594-609. Full Text
  - Lee, H-J, Yoon, C, Park, DJ, Kim, Y-J, Schmidt, B, Lee, Y-J, Tap, WD, Eisinger-Mathason, TSK, Choy, E, Kirsch, DG, Simon, MC, and Yoon, SS. "Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature." International journal of radiation oncology, biology, physics 91, no. 3 (March 2015): 621-630. Full Text
  - Moding, EJ, Castle, KD, Perez, BA, Oh, P, Min, HD, Norris, H, Ma, Y, Cardona, DM, Lee, C-L, and Kirsch, DG. "Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy." Science translational medicine 7, no. 278 (March 2015): 278ra34-. Full Text
  - Bache, ST, Juang, T, Belley, MD, Koontz, BF, Adamovics, J, Yoshizumi, TT, Kirsch, DG, and Oldham, M. "Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters." Medical physics 42, no. 2 (February 2015): 846-855. Full Text
  - Van Mater, D, Añó, L, Blum, JM, Webster, MT, Huang, W, Williams, N, Ma, Y, Cardona, DM, Fan, C-M, and Kirsch, DG. "Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway." Cancer research 75, no. 3 (February 2015): 605-614. Full Text
  - Farin, AM, Manzo, ND, Kirsch, DG, and Stripp, BR. "Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo." Radiation research 183, no. 1 (January 7, 2015): 124-132. Full Text
  - Cramer, CK, Yoon, SW, Reinsvold, M, Joo, KM, Norris, H, Hood, RC, Adamson, JD, Klein, RC, Kirsch, DG, and Oldham, M. "Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats." PloS one 10, no. 12 (January 2015): e0143208-. Full Text
  - Dodd, RD, Añó, L, Blum, JM, Li, Z, Van Mater, D, and Kirsch, DG. "Methods to generate genetically engineered mouse models of soft tissue sarcoma." Methods in molecular biology (Clifton, N.J.) 1267 (January 2015): 283-295. Full Text
  - Lazarides, AL, Eward, WC, Speicher, PJ, Hou, C-H, Nussbaum, DP, Green, C, Blazer, DG, Kirsch, DG, and Brigman, BE. "The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review." Sarcoma 2015 (January 2015): 186581-. Full Text
  - Liu, Y, Ashton, JR, Moding, EJ, Yuan, H, Register, JK, Fales, AM, Choi, J, Whitley, MJ, Zhao, X, Qi, Y, Ma, Y, Vaidyanathan, G, Zalutsky, MR, Kirsch, DG, Badea, CT, and Vo-Dinh, T. "A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy." Theranostics 5, no. 9 (January 2015): 946-960. Full Text Open Access Copy
  - Nussbaum, DP, Speicher, PJ, Gulack, BC, Ganapathi, AM, Englum, BR, Kirsch, DG, Tyler, DS, and Blazer, DG. "Long-term oncologic outcomes after neoadjuvant radiation therapy for retroperitoneal sarcomas." Annals of Surgery 262, no. 1 (2015): 163-170. Full Text
  - Sachdeva, M, Dodd, RD, Huang, Z, Grenier, C, Ma, Y, Lev, DC, Cardona, DM, Murphy, SK, and Kirsch, DG. "Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182." Cancer Letters 369, no. 1 (2015): 202-211. Full Text
  - Asada, K, Canestrari, E, Fu, X, Li, Z, Makowski, E, Wu, Y-C, Mito, JK, Kirsch, DG, Baraban, J, and Paroo, Z. "Rescuing dicer defects via inhibition of an anti-dicing nuclease." Cell reports 9, no. 4 (November 2014): 1471-1481. Full Text
  - Schönhuber, N, Seidler, B, Schuck, K, Veltkamp, C, Schachtler, C, Zukowska, M, Eser, S, Feyerabend, TB, Paul, MC, Eser, P, Klein, S, Lowy, AM, Banerjee, R, Yang, F, Lee, C-L, Moding, EJ, Kirsch, DG, Scheideler, A, Alessi, DR, Varela, I, Bradley, A, Kind, A, Schnieke, AE, Rodewald, H-R, Rad, R, Schmid, RM, Schneider, G, and Saur, D. "A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer." Nature medicine 20, no. 11 (November 2014): 1340-1347. Full Text
  - Wong, P, Houghton, P, Kirsch, DG, Finkelstein, SE, Monjazeb, AM, Xu-Welliver, M, Dicker, AP, Ahmed, M, Vikram, B, Teicher, BA, Coleman, CN, Machtay, M, Curran, WJ, and Wang, D. "Combining targeted agents with modern radiotherapy in soft tissue sarcomas." Journal of the National Cancer Institute 106, no. 11 (November 2014). (Review) Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." The Journal of clinical investigation 124, no. 10 (October 2014): 4305-4319. Full Text
  - Phesse, TJ, Buchert, M, Stuart, E, Flanagan, DJ, Faux, M, Afshar-Sterle, S, Walker, F, Zhang, H-H, Nowell, CJ, Jorissen, R, Tan, CW, Hirokawa, Y, Eissmann, MF, Poh, AR, Malaterre, J, Pearson, HB, Kirsch, DG, Provero, P, Poli, V, Ramsay, RG, Sieber, O, Burgess, AW, Huszar, D, Vincan, E, and Ernst, M. "Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration." Science signaling 7, no. 345 (September 30, 2014): ra92-. Full Text
  - Coleman, CN, Lawrence, TS, and Kirsch, DG. "Enhancing the efficacy of radiation therapy: premises, promises, and practicality." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 26 (September 2014): 2832-2835. Full Text
  - Nussbaum, DP, Speicher, PJ, Gulack, BC, Ganapathi, AM, Keenan, JE, Stinnett, SS, Kirsch, DG, Tyler, DS, and Blazer, DG. "The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas." Surgical oncology 23, no. 3 (September 2014): 155-160. (Review) Full Text
  - Khanna, C, Fan, TM, Gorlick, R, Helman, LJ, Kleinerman, ES, Adamson, PC, Houghton, PJ, Tap, WD, Welch, DR, Steeg, PS, Merlino, G, Sorensen, PHB, Meltzer, P, Kirsch, DG, Janeway, KA, Weigel, B, Randall, L, Withrow, SJ, Paoloni, M, Kaplan, R, Teicher, BA, Seibel, NL, Smith, M, Uren, A, Patel, SR, Trent, J, Savage, SA, Mirabello, L, Reinke, D, Barkaukas, DA, Krailo, M, and Bernstein, M. "Toward a drug development path that targets metastatic progression in osteosarcoma." Clinical cancer research : an official journal of the American Association for Cancer Research 20, no. 16 (August 2014): 4200-4209. Full Text
  - Moding, EJ, Lee, C-L, Castle, KD, Oh, P, Mao, L, Zha, S, Min, HD, Ma, Y, Das, S, and Kirsch, DG. "Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium." The Journal of clinical investigation 124, no. 8 (August 2014): 3325-3338. Full Text
  - Lee, C-L, Lento, WE, Castle, KD, Chao, NJ, and Kirsch, DG. "Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice." Radiation research 181, no. 5 (May 2014): 445-451. Full Text
  - Lee, C-L, Moding, EJ, and Kirsch, DG. "Reining in radiation injury: HIF2α in the gut." Science translational medicine 6, no. 236 (May 2014): 236fs20-. Full Text
  - Perez, BA, Mettu, P, Vajzovic, L, Rivera, D, Alkaissi, A, Steffey, BA, Cai, J, Stinnett, S, Dutton, JJ, Buckley, EG, Halperin, E, Marks, LB, Mruthyunjaya, P, and Kirsch, DG. "Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes." International journal of radiation oncology, biology, physics 89, no. 1 (May 2014): 127-136. Full Text
  - Perez, BA, Mettu, P, Vajzovic, L, Rivera, D, Alkaissi, A, Steffey, BA, Cai, J, Stinnett, S, Dutton, JJ, Buckley, EG, Halperin, E, Marks, LB, Mruthyunjaya, P, and Kirsch, DG. "Uveal melanoma treated with iodine-125 episcleral plaque: An analysis of dose on disease control and visual outcomes." International Journal of Radiation Oncology Biology Physics 89, no. 1 (May 1, 2014): 127-136. Full Text
  - Stanton, IN, Belley, MD, Nguyen, G, Rodrigues, A, Li, Y, Kirsch, DG, Yoshizumi, TT, and Therien, MJ. "Europium- and lithium-doped yttrium oxide nanocrystals that provide a linear emissive response with X-ray radiation exposure." Nanoscale 6, no. 10 (May 2014): 5284-5288. Full Text
  - Lee, C-L, Min, H, Befera, N, Clark, D, Qi, Y, Das, S, Johnson, GA, Badea, CT, and Kirsch, DG. "Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation." International journal of radiation oncology, biology, physics 88, no. 3 (March 2014): 686-693. Full Text Open Access Copy
  - Ashton, JR, Clark, DP, Moding, EJ, Ghaghada, K, Kirsch, DG, West, JL, and Badea, CT. "Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study." PloS one 9, no. 2 (January 2014): e88129-. Full Text Open Access Copy
  - Wallner, PE, Anscher, MS, Barker, CA, Bassetti, M, Bristow, RG, Cha, YI, Dicker, AP, Formenti, SC, Graves, EE, Hahn, SM, Hei, TK, Kimmelman, AC, Kirsch, DG, Kozak, KR, Lawrence, TS, Marples, B, McBride, WH, Mikkelsen, RB, Park, CC, Weidhaas, JB, Zietman, AL, and Steinberg, M. "Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: Report of the american society for radiation oncology cancer biology/radiation biology task force, executive summary." International Journal of Radiation Oncology Biology Physics 88, no. 1 (January 1, 2014): 11-17. Full Text
  - Zhang, M, Linardic, CM, and Kirsch, DG. "RAS and ROS in rhabdomyosarcoma." Cancer Cell 24, no. 6 (December 9, 2013): 689-691. Full Text Link to Item
  - Fu, HL, Mueller, JL, Javid, M, Kirsch, DG, Ramanujam, N, and Brown, JQ. "Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins." CLEO: Applications and Technology, CLEO_AT 2013 (November 19, 2013).
  - Blum, JM, Añó, L, Li, Z, Van Mater, D, Bennett, BD, Sachdeva, M, Lagutina, I, Zhang, M, Mito, JK, Dodd, LG, Cardona, DM, Dodd, RD, Williams, N, Ma, Y, Lepper, C, Linardic, CM, Mukherjee, S, Grosveld, GC, Fan, C-M, and Kirsch, DG. "Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells." Cell reports 5, no. 4 (November 14, 2013): 933-940. Full Text
  - Rankine, LJ, Newton, J, Bache, ST, Das, SK, Adamovics, J, Kirsch, DG, and Oldham, M. "Investigating end-to-end accuracy of image guided radiation treatment delivery using a micro-irradiator." Phys Med Biol 58, no. 21 (November 7, 2013): 7791-7801. Full Text Link to Item
  - Lee, H-J, Yoon, C, Schmidt, B, Park, DJ, Zhang, AY, Erkizan, HV, Toretsky, JA, Kirsch, DG, and Yoon, SS. "Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage." Mol Cancer Ther 12, no. 11 (November 2013): 2591-2600. Full Text Link to Item
  - Eisinger-Mathason, TSK, Zhang, M, Qiu, Q, Skuli, N, Nakazawa, MS, Karakasheva, T, Mucaj, V, Shay, JES, Stangenberg, L, Sadri, N, Puré, E, Yoon, SS, Kirsch, DG, and Simon, MC. "Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis." Cancer Discov 3, no. 10 (October 2013): 1190-1205. Full Text Link to Item
  - Lee, C-L, Blum, JM, and Kirsch, DG. "Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis." Translational cancer research 2, no. 5 (October 2013): 412-421.
  - Dodd, RD, Mito, JK, Eward, WC, Chitalia, R, Sachdeva, M, Ma, Y, Barretina, J, Dodd, L, and Kirsch, DG. "NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition." Mol Cancer Ther 12, no. 9 (September 2013): 1906-1917. Full Text Link to Item
  - Larrier, NA, Kirsch, DG, Riedel, RF, Levinson, H, Eward, WC, and Brigman, BE. "Practical radiation oncology for extremity sarcomas." Surg Oncol Clin N Am 22, no. 3 (July 2013): 433-443. (Review) Full Text Link to Item
  - Moding, EJ, Kastan, MB, and Kirsch, DG. "Strategies for optimizing the response of cancer and normal tissues to radiation." Nat Rev Drug Discov 12, no. 7 (July 2013): 526-542. (Review) Full Text Link to Item
  - Li, Z, Zhang, Y, Ramanujan, K, Ma, Y, Kirsch, DG, and Glass, DJ. "Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway." Cancer Res 73, no. 10 (May 15, 2013): 3041-3050. Full Text Link to Item
  - Cuneo, KC, Mito, JK, Javid, MP, Ferrer, JM, Kim, Y, Lee, WD, Bawendi, MG, Brigman, BE, and Kirsch, DG. "Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents." Int J Radiat Oncol Biol Phys 86, no. 1 (May 1, 2013): 136-142. Full Text Link to Item
  - Moding, EJ, Clark, DP, Qi, Y, Li, Y, Ma, Y, Ghaghada, K, Johnson, GA, Kirsch, DG, and Badea, CT. "Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas." Int J Radiat Oncol Biol Phys 85, no. 5 (April 1, 2013): 1353-1359. Full Text Link to Item
  - Clark, DP, Ghaghada, K, Moding, EJ, Kirsch, DG, and Badea, CT. "In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT." Phys Med Biol 58, no. 6 (March 21, 2013): 1683-1704. Full Text Link to Item
  - Doan, PL, Himburg, HA, Helms, K, Russell, JL, Fixsen, E, Quarmyne, M, Harris, JR, Deoliviera, D, Sullivan, JM, Chao, NJ, Kirsch, DG, and Chute, JP. "Epidermal growth factor regulates hematopoietic regeneration after radiation injury." Nat Med 19, no. 3 (March 2013): 295-304. Full Text Open Access Copy Link to Item
  - Eward, WC, Mito, JK, Eward, CA, Carter, JE, Ferrer, JM, Kirsch, DG, and Brigman, BE. "A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs." Clin Orthop Relat Res 471, no. 3 (March 2013): 834-842. Full Text Link to Item
  - Doan, PL, Russell, JL, Himburg, HA, Helms, K, Harris, JR, Lucas, J, Holshausen, KC, Meadows, SK, Daher, P, Jeffords, LB, Chao, NJ, Kirsch, DG, and Chute, JP. "Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury." Stem Cells 31, no. 2 (February 2013): 327-337. Full Text Link to Item
  - Subashi, E, Moding, EJ, Cofer, GP, MacFall, JR, Kirsch, DG, Qi, Y, and Johnson, GA. "A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models." Med Phys 40, no. 2 (February 2013): 022304-. Full Text Link to Item
  - Bahig, H, Roberge, D, Bosch, W, Levin, W, Petersen, I, Haddock, M, Freeman, C, DeLaney, TF, Abrams, RA, Indelicato, DJ, and al, E. "Agreement Among RTOG Sarcoma Radiation Oncologists in Contouring Suspicious Peritumoral Edema for Preoperative Radiation Therapy of Soft Tissue Sarcoma of the Extremity." International Journal of Radiation Oncology, Biology, Physics (2013). Full Text
  - Bahig, H, Roberge, D, Bosch, W, Levin, W, Petersen, I, Haddock, M, Freeman, C, Delaney, TF, Abrams, RA, Indelicato, DJ, Baldini, EH, Hitchcock, Y, Kirsch, DG, Kozak, KR, Wolfson, A, and Wang, D. "Agreement among RTOG sarcoma radiation oncologists in contouring suspicious peritumoral edema for preoperative radiation therapy of soft tissue sarcoma of the extremity." International Journal of Radiation Oncology Biology Physics 86, no. 2 (2013): 298-303. Full Text
  - Barton, KL, Misuraca, K, Cordero, F, Dobrikova, E, Min, HD, Gromeier, M, Kirsch, DG, and Becher, OJ. "PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma." PloS one 8, no. 10 (January 2013): e77639-. Full Text
  - Chen, Y-L, Liebsch, N, Kobayashi, W, Goldberg, S, Kirsch, D, Calkins, G, Childs, S, Schwab, J, Hornicek, F, and Delaney, T. "Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas." Spine 38, no. 15 (2013): E930-E936. Full Text
  - Cuneo, KC, Mito, JK, Javid, MP, Ferrer, JM, Kim, Y, Lee, WD, Bawendi, MG, Brigman, BE, and Kirsch, DG. "Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents." International Journal of Radiation Oncology Biology Physics 86, no. 1 (2013): 136-142. Full Text
  - Eward, WC, Mito, JK, Eward, CA, Carter, JE, Ferrer, JM, Kirsch, DG, and Brigman, BE. "A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs tumor." Clinical Orthopaedics and Related Research 471, no. 3 (2013): 834-842. Full Text
  - Fu, HL, Mueller, JL, Javid, M, Kirsch, DG, Ramanujam, N, and Brown, JQ. "Optimization of illumination frequency and preclinical validation of a wide-field structured illumination microscope designed for imaging in situ tumor margins." 2013 Conference on Lasers and Electro-Optics, CLEO 2013 (January 1, 2013).
  - Fu, HL, Mueller, JL, Javid, MP, Mito, JK, Kirsch, DG, Ramanujam, N, and Brown, JQ. "Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma." PloS one 8, no. 7 (January 2013): e68868-. Full Text
  - Li, Z, Gilbert, JA, Zhang, Y, Zhang, M, Qiu, Q, Ramanujan, K, Shavlakadze, T, Eash, JK, Scaramozza, A, Goddeeris, MM, Kirsch, DG, Campbell, KP, Brack, AS, and Glass, DJ. "An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis." Developmental Cell 24, no. 1 (2013): 112--. Full Text
  - Mito, JK, Min, HD, Ma, Y, Carter, JE, Brigman, BE, Dodd, L, Dankort, D, McMahon, M, and Kirsch, DG. "Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma." J Pathol 229, no. 1 (January 2013): 132-140. Full Text Link to Item
  - Mito, JK, Min, HD, Ma, Y, Carter, JE, Brigman, BE, Dodd, L, Dankort, D, McMahon, M, and Kirsch, DG. "Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma." Journal of Pathology 229, no. 1 (2013): 132-140. Full Text
  - Moding, EJ, Clark, DP, Qi, Y, Li, Y, Ma, Y, Ghaghada, K, Johnson, GA, Kirsch, DG, and Badea, CT. "Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas." International Journal of Radiation Oncology Biology Physics 85, no. 5 (2013): 1353-1359. Full Text
  - Mueller, JL, Harmany, ZT, Mito, JK, Kennedy, SA, Kim, Y, Dodd, L, Geradts, J, Kirsch, DG, Willett, RM, Brown, JQ, and Ramanujam, N. "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Approach for tuning algorithm parameters." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8587 (2013). Full Text
  - Mueller, JL, Harmany, ZT, Mito, JK, Kennedy, SA, Kim, Y, Dodd, L, Geradts, J, Kirsch, DG, Willett, RM, Brown, JQ, and Ramanujam, N. "Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins. (Published online)" PLoS One 8, no. 6 (2013): e66198-. Full Text Link to Item
  - Perez, BA, Ghafoori, AP, Lee, C-L, Johnston, SM, Li, Y, Moroshek, JG, Ma, Y, Mukherjee, S, Kim, Y, Badea, CT, and Kirsch, DG. "Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice. (Published online)" Front Oncol 3 (2013): 72-. Full Text Link to Item
  - Wallner, PE, Anscher, MS, Barker, CA, Bassetti, M, Bristow, RG, Cha, YI, Dicker, AP, Formenti, SC, Graves, EE, Hahn, SM, Hei, TK, Kimmelman, AC, Kirsch, DG, Kozak, KR, Lawrence, TS, Marples, B, McBride, WH, Mikkelsen, RB, Park, CC, Weidhaas, JB, Zietman, AL, and Steinberg, M. "Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary." International Journal of Radiation Oncology, Biology, Physics (2013).
  - Li, Z, Gilbert, JA, Zhang, Y, Zhang, M, Qiu, Q, Ramanujan, K, Shavlakadze, T, Eash, JK, Scaramozza, A, Goddeeris, MM, Kirsch, DG, Campbell, KP, Brack, AS, and Glass, DJ. "An HMGA2-IGF2BP2 Axis Regulates Myoblast Proliferation and Myogenesis." DEVELOPMENTAL CELL 23, no. 6 (December 11, 2012): 1176-1188. Full Text Link to Item
  - Mito, JK, Ferrer, JM, Brigman, BE, Lee, C-L, Dodd, RD, Eward, WC, Marshall, LF, Cuneo, KC, Carter, JE, Ramasunder, S, Kim, Y, Lee, WD, Griffith, LG, Bawendi, MG, and Kirsch, DG. "Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging." Cancer 118, no. 21 (November 1, 2012): 5320-5330. Full Text Link to Item
  - Cuneo, KC, Riedel, RF, Dodd, LG, Harpole, DH, and Kirsch, DG. "Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy." J Clin Oncol 30, no. 28 (October 1, 2012): e291-e293. Full Text Link to Item
  - Wang, D, Bosch, W, Roberge, D, Finkelstein, SE, Petersen, I, Haddock, M, Chen, Y-LE, Delaney, TF, Saito, NG, Kirsch, DG, Hitchcock, YJ, and Wolfson, AH. "In Reply to O'Sullivan et al." Int J Radiat Oncol Biol Phys 84, no. 2 (October 1, 2012): 307-308. (Letter) Full Text Link to Item
  - Lee, C-L, Moding, EJ, Cuneo, KC, Li, Y, Sullivan, JM, Mao, L, Washington, I, Jeffords, LB, Rodrigues, RC, Ma, Y, Das, S, Kontos, CD, Kim, Y, Rockman, HA, and Kirsch, DG. "p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. (Published online)" Sci Signal 5, no. 234 (July 24, 2012): ra52-. Full Text Link to Item
  - Rodrigues, A, Nguyen, G, Li, Y, Roy Choudhury, K, Kirsch, D, Das, S, and Yoshizumi, T. "SU-E-T-275: Dose Verification in a Small Animal Image-Guided Radiation Therapy X-Ray Machine: A Dose Comparison between TG-61 Based Look-Up Table and MOSFET Method for Various Collimator Sizes." Medical physics 39, no. 6Part14 (June 2012): 3766-. Full Text
  - Lee, C-L, Moding, EJ, Huang, X, Li, Y, Woodlief, LZ, Rodrigues, RC, Ma, Y, and Kirsch, DG. "Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice." Dis Model Mech 5, no. 3 (May 2012): 397-402. Full Text Link to Item
  - Sullivan, JM, Jeffords, LB, Lee, C-L, Rodrigues, R, Ma, Y, and Kirsch, DG. "p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome." Radiat Res 177, no. 3 (March 2012): 307-310. Link to Item
  - Badea, CT, Athreya, KK, Espinosa, G, Clark, D, Ghafoori, AP, Li, Y, Kirsch, DG, Johnson, GA, Annapragada, A, and Ghaghada, KB. "Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent." PLoS One 7, no. 4 (2012): e34496-. Full Text Link to Item
  - Bell, RC, Rogith, D, Johnson, CW, Badea, CT, Athreya, KK, Espinosa, G, Clark, D, Ghafoori, AP, Li, Y, Kirsch, DG, Annapragada, A, and Ghaghada, K. "Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model." AMIA Annu Symp Proc 2012 (2012): 27-35. Link to Item
  - Belyea, B, Kephart, JG, Blum, J, Kirsch, DG, and Linardic, CM. "Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting." Sarcoma 2012 (2012): 406239-. Full Text Link to Item
  - Kim, S, Dodd, RD, Mito, JK, Ma, Y, Kim, Y, Riedel, RF, and Kirsch, DG. "Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma." Sarcoma 2012 (2012): 680708-. Full Text Link to Item
  - Newton, J, Oldham, M, Thomas, A, Li, Y, Adamovics, J, Kirsch, DG, and Das, S. "Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques." Med Phys 38, no. 12 (December 2011): 6754-6762. Full Text Link to Item
  - Omotosho, P, Yurcisin, B, Ceppa, E, Miller, J, Kirsch, D, and Portenier, DD. "In vivo assessment of an absorbable and nonabsorbable knotless barbed suture for laparoscopic single-layer enterotomy closure: a clinical and biomechanical comparison against nonbarbed suture." J Laparoendosc Adv Surg Tech A 21, no. 10 (December 2011): 893-897. Full Text Link to Item
  - Wang, D, Bosch, W, Kirsch, DG, Al Lozi, R, El Naqa, I, Roberge, D, Finkelstein, SE, Petersen, I, Haddock, M, Chen, Y-LE, Saito, NG, Hitchcock, YJ, Wolfson, AH, and DeLaney, TF. "Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists." Int J Radiat Oncol Biol Phys 81, no. 5 (December 1, 2011): e775-e780. Full Text Link to Item
  - Wang, D, Bosch, W, Roberge, D, Finkelstein, SE, Petersen, I, Haddock, M, Chen, Y-LE, Saito, NG, Kirsch, DG, Hitchcock, YJ, Wolfson, AH, and DeLaney, TF. "RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies." Int J Radiat Oncol Biol Phys 81, no. 4 (November 15, 2011): e525-e528. Full Text Link to Item
  - Yoon, SS, Duda, DG, Karl, DL, Kim, T-M, Kambadakone, AR, Chen, Y-L, Rothrock, C, Rosenberg, AE, Nielsen, GP, Kirsch, DG, Choy, E, Harmon, DC, Hornicek, FJ, Dreyfuss, J, Ancukiewicz, M, Sahani, DV, Park, PJ, Jain, RK, and Delaney, TF. "Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas." Int J Radiat Oncol Biol Phys 81, no. 4 (November 15, 2011): 1081-1090. Full Text Link to Item
  - Kirsch, DG. "Using genetically engineered mice for radiation research." Radiat Res 176, no. 3 (September 2011): 275-279. Link to Item
  - Weidhaas, JB, and Kirsch, DG. "The Holman Research Pathway in radiation oncology." Int J Radiat Oncol Biol Phys 80, no. 2 (June 1, 2011): 321-323. Full Text Link to Item
  - Kirsch, DG, Grimm, J, Guimaraes, AR, and Weissleder, R. "In response to Dr. Garbow and colleagues." International Journal of Radiation Oncology Biology Physics 79, no. 3 (2011): 959--. Full Text
  - Kirsch, DG. "p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis (Science (593), (2010))." Science 334, no. 6057 (2011): 761--. Full Text
  - Dodd, RD, Mito, JK, and Kirsch, DG. "Animal models of soft-tissue sarcoma." Dis Model Mech 3, no. 9-10 (September 2010): 557-566. (Review) Full Text Open Access Copy Link to Item
  - Curtis, SJ, Sinkevicius, KW, Li, D, Lau, AN, Roach, RR, Zamponi, R, Woolfenden, AE, Kirsch, DG, Wong, K-K, and Kim, CF. "Primary tumor genotype is an important determinant in identification of lung cancer propagating cells." Cell Stem Cell 7, no. 1 (July 2, 2010): 127-133. Full Text Link to Item
  - Kim, B, Chen, Y-LE, Kirsch, DG, Goldberg, SI, Kobayashi, W, Kung, JH, Wolfgang, JA, Doppke, K, Rosenberg, AE, Nielsen, GP, Raskin, KA, Springfield, DS, Schwab, JH, Gebhardt, MC, Yoon, SS, Hornicek, FJ, and DeLaney, TF. "An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control." Int J Radiat Oncol Biol Phys 77, no. 3 (July 1, 2010): 843-850. Full Text Link to Item
  - Yoon, SS, Chen, Y-L, Kirsch, DG, Maduekwe, UN, Rosenberg, AE, Nielsen, GP, Sahani, DV, Choy, E, Harmon, DC, and DeLaney, TF. "Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas." Ann Surg Oncol 17, no. 6 (June 2010): 1515-1529. Full Text Link to Item
  - Williams, JP, Brown, SL, Georges, GE, Hauer-Jensen, M, Hill, RP, Huser, AK, Kirsch, DG, Macvittie, TJ, Mason, KA, Medhora, MM, Moulder, JE, Okunieff, P, Otterson, MF, Robbins, ME, Smathers, JB, and McBride, WH. "Animal models for medical countermeasures to radiation exposure." Radiat Res 173, no. 4 (April 2010): 557-578. Full Text Link to Item
  - Kirsch, DG, Grimm, J, Guimaraes, AR, Wojtkiewicz, GR, Perez, BA, Santiago, PM, Anthony, NK, Forbes, T, Doppke, K, Weissleder, R, and Jacks, T. "Imaging primary lung cancers in mice to study radiation biology." Int J Radiat Oncol Biol Phys 76, no. 4 (March 15, 2010): 973-977. Full Text Link to Item
  - Johnston, SM, Perez, BA, Kirsch, DG, and Badea, CT. "Phase-selective image reconstruction of the lungs in small animals using Micro-CT." Proc SPIE Int Soc Opt Eng 7622 (February 15, 2010): 76223G.1-76223G.9. Full Text Link to Item
  - Kirsch, DG, Santiago, PM, di Tomaso, E, Sullivan, JM, Hou, W-S, Dayton, T, Jeffords, LB, Sodha, P, Mercer, KL, Cohen, R, Takeuchi, O, Korsmeyer, SJ, Bronson, RT, Kim, CF, Haigis, KM, Jain, RK, and Jacks, T. "p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis." Science 327, no. 5965 (January 29, 2010): 593-596. Full Text Link to Item
  - Kumar, MS, Pester, RE, Chen, CY, Lane, K, Chin, C, Lu, J, Kirsch, DG, Golub, TR, and Jacks, T. "Dicer1 functions as a haploinsufficient tumor suppressor." Genes Dev 23, no. 23 (December 1, 2009): 2700-2704. Full Text Link to Item
  - Mito, JK, Riedel, RF, Dodd, L, Lahat, G, Lazar, AJ, Dodd, RD, Stangenberg, L, Eward, WC, Hornicek, FJ, Yoon, SS, Brigman, BE, Jacks, T, Lev, D, Mukherjee, S, and Kirsch, DG. "Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. (Published online)" PLoS One 4, no. 11 (November 30, 2009): e8075-. Full Text Link to Item
  - Yoon, SS, Stangenberg, L, Lee, Y-J, Rothrock, C, Dreyfuss, JM, Baek, K-H, Waterman, PR, Nielsen, GP, Weissleder, R, Mahmood, U, Park, PJ, Jacks, T, Dodd, RD, Fisher, CJ, Ryeom, S, and Kirsch, DG. "Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma." Int J Radiat Oncol Biol Phys 74, no. 4 (July 15, 2009): 1207-1216. Full Text Link to Item
  - Riedel, RF, Larrier, N, Dodd, L, Kirsch, D, Martinez, S, and Brigman, BE. "The clinical management of chondrosarcoma." Curr Treat Options Oncol 10, no. 1-2 (April 2009): 94-106. (Review) Full Text Link to Item
  - Demyttenaere, SV, Nau, P, Henn, M, Beck, C, Zaruby, J, Primavera, M, Kirsch, D, Miller, J, Liu, JJ, Bellizzi, A, and Melvin, WS. "Barbed suture for gastrointestinal closure: A randomized control trial." Surgical Innovation 16, no. 3 (2009): 237-242. Full Text
  - Wagner, TD, Kobayashi, W, Dean, S, Goldberg, SI, Kirsch, DG, Suit, HD, Hornicek, FJ, Pedlow, FX, Raskin, KA, Springfield, DS, Yoon, SS, Gebhardt, MC, Mankin, HJ, and Delaney, TF. "Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone." Int J Radiat Oncol Biol Phys 73, no. 1 (January 1, 2009): 259-266. Full Text Link to Item
  - Niedre, MJ, de Kleine, RH, Aikawa, E, Kirsch, DG, Weissleder, R, and Ntziachristos, V. "Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo." Proc Natl Acad Sci U S A 105, no. 49 (December 9, 2008): 19126-19131. Full Text Link to Item
  - Lin, NU, Carey, LA, Liu, MC, Younger, J, Come, SE, Ewend, M, Harris, GJ, Bullitt, E, Van den Abbeele, AD, Henson, JW, Li, X, Gelman, R, Burstein, HJ, Kasparian, E, Kirsch, DG, Crawford, A, Hochberg, F, and Winer, EP. "Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer." J Clin Oncol 26, no. 12 (April 20, 2008): 1993-1999. Full Text Link to Item
  - Kirsch, DG, Dinulescu, DM, Miller, JB, Grimm, J, Santiago, PM, Young, NP, Nielsen, GP, Quade, BJ, Chaber, CJ, Schultz, CP, Takeuchi, O, Bronson, RT, Crowley, D, Korsmeyer, SJ, Yoon, SS, Hornicek, FJ, Weissleder, R, and Jacks, T. "A spatially and temporally restricted mouse model of soft tissue sarcoma." Nat Med 13, no. 8 (August 2007): 992-997. Full Text Link to Item
  - Abraham, JA, Hornicek, FJ, Kaufman, AM, Harmon, DC, Springfield, DS, Raskin, KA, Mankin, HJ, Kirsch, DG, Rosenberg, AE, Nielsen, GP, Desphpande, V, Suit, HD, DeLaney, TF, and Yoon, SS. "Treatment and outcome of 82 patients with angiosarcoma." Ann Surg Oncol 14, no. 6 (June 2007): 1953-1967. Full Text Link to Item
  - Delaney, TF, Kepka, L, Goldberg, SI, Hornicek, FJ, Gebhardt, MC, Yoon, SS, Springfield, DS, Raskin, KA, Harmon, DC, Kirsch, DG, Mankin, HJ, Rosenberg, AE, Nielsen, GP, and Suit, HD. "Radiation therapy for control of soft-tissue sarcomas resected with positive margins." Int J Radiat Oncol Biol Phys 67, no. 5 (April 1, 2007): 1460-1469. Full Text Link to Item
  - Ventura, A, Kirsch, DG, McLaughlin, ME, Tuveson, DA, Grimm, J, Lintault, L, Newman, J, Reczek, EE, Weissleder, R, and Jacks, T. "Restoration of p53 function leads to tumour regression in vivo." Nature 445, no. 7128 (February 8, 2007): 661-665. Full Text Link to Item
  - Chen, Y-B, Seo, SY, Kirsch, DG, Sheu, T-T, Cheng, W-C, and Hardwick, JM. "Alternate functions of viral regulators of cell death." Cell Death Differ 13, no. 8 (August 2006): 1318-1324. (Review) Full Text Link to Item
  - Grimm, J, Kirsch, DG, Windsor, SD, Kim, CFB, Santiago, PM, Ntziachristos, V, Jacks, T, and Weissleder, R. "Use of gene expression profiling to direct in vivo molecular imaging of lung cancer." Proc Natl Acad Sci U S A 102, no. 40 (October 4, 2005): 14404-14409. Full Text Link to Item
  - Kirsch, DG, Ebb, DH, Hernandez, AH, and Tarbell, NJ. "Proton radiotherapy for Hodgkin's disease in the sacrum." Lancet Oncol 6, no. 7 (July 2005): 532-533. Full Text Link to Item
  - Shaw, AT, Kirsch, DG, and Jacks, T. "Future of early detection of lung cancer: the role of mouse models." Clinical cancer research : an official journal of the American Association for Cancer Research 11, no. 13 Pt 2 (July 1, 2005). (Review)
  - Shaw, AT, Kirsch, DG, and Jacks, T. "Future of early detection of lung cancer: the role of mouse models." Clin Cancer Res 11, no. 13 Pt 2 (July 1, 2005): 4999s-5003s. (Review) Full Text Link to Item
  - Kirsch, DG, and Loeffler, JS. "Brain metastases in patients with breast cancer: new horizons." Clin Breast Cancer 6, no. 2 (June 2005): 115-124. (Review) Full Text Link to Item
  - Kirsch, DG, Ledezma, CJ, Mathews, CS, Bhan, AK, Ancukiewicz, M, Hochberg, FH, and Loeffler, JS. "Survival after brain metastases from breast cancer in the trastuzumab era." J Clin Oncol 23, no. 9 (March 20, 2005): 2114-2116. (Letter) Full Text Link to Item
  - Kim, CFB, Jackson, EL, Kirsch, DG, Grimm, J, Shaw, AT, Lane, K, Kissil, J, Olive, KP, Sweet-Cordero, A, Weissleder, R, and Jacks, T. "Mouse models of human non-small-cell lung cancer: raising the bar." Cold Spring Harb Symp Quant Biol 70 (2005): 241-250. (Review) Full Text Link to Item
  - Kirsch, DG, and Loeffler, JS. "Treating brain metastases: current approaches and future directions." Expert Rev Neurother 4, no. 6 (November 2004): 1015-1022. (Review) Full Text Link to Item
  - Kirsch, DG, and Tarbell, NJ. "New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy." Pediatr Blood Cancer 42, no. 5 (May 2004): 461-464. (Review) Full Text Link to Item
  - Kirsch, DG, and Loeffler, JS. "The controversy of adjuvant whole-brain radiation therapy." Journal of Supportive Oncology 2, no. 5 (2004): 412-414.
  - Kirsch, DG, and Tarbell, NJ. "Conformal radiation therapy for childhood CNS tumors." Oncologist 9, no. 4 (2004): 442-450. (Review) Link to Item
  - Kirsch, DG, and Hochberg, FH. "Targeting HER2 in brain metastases from breast cancer." Clin Cancer Res 9, no. 15 (November 15, 2003): 5435-5436. Link to Item
  - Kouba, DJ, Kirsch, DG, Mimouni, D, and Nousari, CH. "Wegener's granulomatosis with cardiac involvement masquerading as Lyme disease." Clin Exp Rheumatol 21, no. 5 (September 2003): 647-649. Link to Item
  - Somme, S, Rodriguez, JA, Kirsch, DG, and Liu, DC. "Laparoscopic versus open fundoplication in infants." Surg Endosc 16, no. 1 (January 2002): 54-56. Full Text Link to Item
  - Kirsch, DG, Doseff, A, Chau, BN, Lim, DS, de Souza-Pinto, NC, Hansford, R, Kastan, MB, Lazebnik, YA, and Hardwick, JM. "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c." J Biol Chem 274, no. 30 (July 23, 1999): 21155-21161. Link to Item
  - Rhodes, N, D'Souza, T, Foster, CD, Ziv, Y, Kirsch, DG, Shiloh, Y, Kastan, MB, Reinhart, PH, and Gilmer, TM. "Defective potassium currents in ataxia telangiectasia fibroblasts." Genes Dev 12, no. 23 (December 1, 1998): 3686-3692. Link to Item
  - Kirsch, DG, and Kastan, MB. "Tumor-suppressor p53: implications for tumor development and prognosis." J Clin Oncol 16, no. 9 (September 1998): 3158-3168. (Review) Full Text Link to Item
  - Lim, DS, Kirsch, DG, Canman, CE, Ahn, JH, Ziv, Y, Newman, LS, Darnell, RB, Shiloh, Y, and Kastan, MB. "ATM binds to beta-adaptin in cytoplasmic vesicles." Proc Natl Acad Sci U S A 95, no. 17 (August 18, 1998): 10146-10151. Link to Item
  - Clem, RJ, Cheng, EH, Karp, CL, Kirsch, DG, Ueno, K, Takahashi, A, Kastan, MB, Griffin, DE, Earnshaw, WC, Veliuona, MA, and Hardwick, JM. "Modulation of cell death by Bcl-XL through caspase interaction." Proc Natl Acad Sci U S A 95, no. 2 (January 20, 1998): 554-559. Link to Item
  - Cheng, EH, Kirsch, DG, Clem, RJ, Ravi, R, Kastan, MB, Bedi, A, Ueno, K, and Hardwick, JM. "Conversion of Bcl-2 to a Bax-like death effector by caspases." Science 278, no. 5345 (December 12, 1997): 1966-1968. Link to Item
  - Agani, F, Kirsch, DG, Friedman, SL, Kastan, MB, and Semenza, GL. "p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene." Cancer Res 57, no. 20 (October 15, 1997): 4474-4477. Link to Item
  - Kastan, MB, Morgan, SE, Siliciano, J, Kirsch, D, Dennis, P, and Canman, CE. "Cell cycle and cell death after DNA damaye." FASEB Journal 11, no. 9 (1997): A878-.
  - Rosmarin, AG, Caprio, DG, Kirsch, DG, Handa, H, and Simkevich, CP. "GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription." J Biol Chem 270, no. 40 (October 6, 1995): 23627-23633. Link to Item
  - Smidt, CR, Bean-Knudsen, D, Kirsch, DG, and Rucker, RB. "Does the intestinal microflora synthesize pyrroloquinoline quinone?." Biofactors 3, no. 1 (January 1991): 53-59. Link to Item
  - Macy, JM, Michel, TA, and Kirsch, DG. "Selenate reduction by a Pseudomonas species: a new mode of anaerobic respiration." FEMS Microbiol Lett 52, no. 1-2 (October 1, 1989): 195-198. Link to Item
  - Shull, LR, Kirsch, DG, Lohse, CL, and Wisniewski, JA. "Application of isolated hepatocytes to studies of drug metabolism in large food animals." Xenobiotica 17, no. 3 (March 1987): 345-363. (Review) Full Text Link to Item
  - Shull, LR, Kirsch, DG, Lohse, CL, Carlson, GP, Doody, LA, and Wisniewski, JA. "Xenobiotic metabolism in suspensions and primary cultures of isolated hepatocytes prepared from the caudate process of bovine liver." Am J Vet Res 47, no. 9 (September 1986): 2043-2052. Link to Item
Teaching & Mentoring
Recent Courses
- PHARM 393: Research Independent Study 2017
- PHARM 394: Research Independent Study 2017
- PHARM 493: Research Independent Study 2017
- PHARM 494: Research Independent Study 2017
- PHARM 495: Research Independent Study 2015

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