David Joseph Madden

Journal article Biochim Biophys Acta · March 2012 Featured Publication In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension ... Full text Open Access Link to item Cite

The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity.

Journal article Cereb Cortex · January 2012 Featured Publication Contralateral recruitment remains a controversial phenomenon in both the clinical and normative populations. To investigate the neural correlates of this phenomenon, we explored the tendency for older adults to recruit prefrontal cortex (PFC) regions contr ... Full text Open Access Link to item Cite

White matter integrity correlates of implicit sequence learning in healthy aging.

Journal article Neurobiol Aging · December 2011 Featured Publication Previous research has identified subcortical (caudate, putamen, hippocampus) and cortical (dorsolateral prefrontal cortex, DLPFC; frontal motor areas) regions involved in implicit sequence learning, with mixed findings for whether these neural substrates d ... Full text Open Access Link to item Cite

Adult age differences in functional connectivity during executive control.

Journal article Neuroimage · August 15, 2010 Featured Publication Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task blocks versus single-task bl ... Full text Open Access Link to item Cite

Toward discovery science of human brain function.

Journal article Proc Natl Acad Sci U S A · March 9, 2010 Featured Publication Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems ... Full text Open Access Link to item Cite

Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging.

Journal article Neuropsychol Rev · December 2009 Featured Publication The integrity of cerebral white matter is critical for efficient cognitive functioning, but little is known regarding the role of white matter integrity in age-related differences in cognition. Diffusion tensor imaging (DTI) measures the directional displa ... Full text Open Access Link to item Cite

Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity.

Journal article Brain Struct Funct · October 2009 Featured Publication Functional connectivity (FC) reflects the coherence of spontaneous, low-frequency fluctuations in functional magnetic resonance imaging (fMRI) data. We report a behavior-based connectivity analysis method, in which whole-brain data are used to identify beh ... Full text Link to item Cite

Cerebral white matter integrity mediates adult age differences in cognitive performance.

Journal article J Cogn Neurosci · February 2009 Featured Publication Previous research has established that age-related decline occurs in measures of cerebral white matter integrity, but the role of this decline in age-related cognitive changes is not clear. To conclude that white matter integrity has a mediating (causal) c ... Full text Link to item Cite

Age-related increase in top-down activation of visual features.

Journal article Q J Exp Psychol (Hove) · May 2007 Featured Publication Previous research suggests that, during visual search and discrimination tasks, older adults place greater emphasis than younger adults on top-down attention. This experiment investigated the relative contribution of target activation and distractor inhibi ... Full text Link to item Cite

Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study.

Journal article Neurobiol Aging · March 2007 Featured Publication We combined measures from event-related functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and cognitive performance (visual search response time) to test the hypotheses that differences between younger and older adults in top-do ... Full text Link to item Cite

A diffusion model analysis of adult age differences in episodic and semantic long-term memory retrieval.

Journal article J Exp Psychol Learn Mem Cogn · January 2006 Featured Publication Two experiments investigated adult age differences in episodic and semantic long-term memory tasks, as a test of the hypothesis of specific age-related decline in context memory. Older adults were slower and exhibited lower episodic accuracy than younger a ... Full text Link to item Cite

Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time.

Journal article Neuroimage · March 2004 Featured Publication Diffusion tensor imaging (DTI) measures the displacement of water molecules across tissue components, thus providing information regarding the microstructure of cerebral white matter. Fractional anisotropy (FA), the degree to which diffusion is directional ... Full text Link to item Cite