Scholars@Duke
David Bruce Matchar

David Bruce Matchar

Professor Emeritus of Medicine
Medicine, General Internal Medicine
Box 102811, DUMC, Durham, NC 27705
Erwin Terrace II, Box 16, Durham, NC 27710

Scholarly Works - Preprints

Walking in the Free World: Establishing Normative Trajectories for Ecological Assessment of Robust Gait Variability with Age

Preprint · March 6, 2026 Abstract Gait variability is a critical functional indicator of dynamic balance and neurocognitive decline in health. Its translation into clinical practice is, however, challenged by a la ... Full text Cite

Genetic Testing for Lynch Syndrome in Singapore: A Cost-Utility and Budget Impact Analysis

Preprint · 2026 ​BackgroundUniversal genetic testing (GT) has been proposed as a public health strategy to reduce Lynch syndrome (LS)-related cancer burden, but lacks economic validation in Singapore. We aimed to identify the most cost-effective LS diagnostic stra ... Full text Cite

Genetic Testing for Hereditary Breast and Ovarian Cancer Syndrome in Singapore: A Cost-Utility and Budget Impact Analysis

Preprint · 2026 Background: Upfront germline genetic testing (GT) has been shown to be cost-effective for diagnosing hereditary breast and ovarian cancer (HBOC) and reducing the hereditary cancer burden in many high-income countries, but lacks economic validation ... Full text Cite

Does Enhancing Primary Care Improve Health and Reduce Healthcare Costs in an Ageing Population? A Systems Model of a National Primary Care Initiative in Singapore

Preprint · 2026 Background: Across health systems globally, transforming hospital-centric care toward strong, integrated primary care (PC) remains an elusive goal. Despite wide consensus on PC’s value, policymakers lack tools to anticipate how large-scale reforms ... Full text Cite