David Mummy

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleThe Lung Health Cohort (LHC) is examining determinants of lung health in 4000 young adults. In this ancillary ... Full text Cite

C108-11 XeLHC: Xenon Mri and Lung Function in Young Adults From the Lung Health Cohort

D21-05 Leptin- and Oxidative Stress-induced Periostin Secretion in Airway Fibroblasts Is Associated With 129XeMRI-localized Abnormal Airway Regions in Asthma With Comorbid Obesity

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleObesity, a prevalent comorbidity of asthma, worsens disease severity and blunts responses to asthma therapies. ... Full text Cite

B22-04 Oxidant Stress Associates With Regional Ventilation Impairment in Comorbid Obesity and Asthma

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleObesity increases the severity of asthma and modifies airway pathobiology, contributing to a lack of responsiv ... Full text Cite

C73-03 Elevated Membrane Uptake Seen on 129Xe MRI Reduces Effective KCO

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleDiffusion of carbon monoxide (DLCO) is affected by the conductances of both the membrane and capillary blood v ... Full text Cite

C108-12 Illuminating Pulmonary Function on CT With Integrated 129Xe MRI Gas Exchange Maps

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationalePrevious work has demonstrated basic regional correlations between CT findings and hyperpolarized 129Xe MRI im ... Full text Cite

C18-06 Establishing Standardized Mapping of 129Xe Frequency Shift Heterogeneity in Capillary Red Blood Cells

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleInhaled hyperpolarized 129Xe exhibits a unique frequency shift in pulmonary capillary red blood cells (RBCs), ... Full text Cite

C73-05 Same Session Repeatability of Single-breath Fractional Ventilation Measurements Derived From 129Xe Gas Exchange Mri

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationaleConventional methods of assessing 129Xe ventilation use histogram-based techniques such as rescaling to arbitr ... Full text Cite

A110-15 Functional Xenon Imaging in Pulmonary Sarcoidosis - First Impressions From a Multi-center Cohort

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2026 AbstractRationalePulmonary sarcoidosis is a granulomatous inflammatory disease with variable rates of persistence, progression, ... Full text Cite

DIFFERENTIATING MACRO-AND MICROVASCULAR DISEASE IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION WITH HYPERPOLARIZED 129XENON MAGNETIC RESONANCE IMAGING

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · July 2025 Link to item Cite

The Age-dependent Upper Limit of Normal for Hyperpolarized 129Xe MRI Ventilation Defect Percent in Healthy Individuals Using a Multi-center Database

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Hyperpolarized 129Xe magnetic resonance imaging (129XeMRI) is an innovative, clinically approved imaging technique that provides novel insights into lung structure and function such as ... Full text Cite

Mapping the Chemical Shift of 129Xe in Red Blood Cells as a Biomarker for Pulmonary Hypertension

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Inhaled hyperpolarized 129Xe exhibits a distinct resonance in the red blood cells (RBCs) of the pulmonary capillaries, allowing MR imaging and spectroscopy (MRI/MRS) of the distal pulmo ... Full text Cite

Multi-site Analysis of Functional Gas Exchange Measures on 129Xe MRI Among Healthy Volunteers

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRATIONALE: Hyperpolarized 129Xe gas exchange MRI has shown promise as a diagnostic and prognostic tool for diverse cardiopulmonary conditions, including asthma, COPD, and interstitial lung disease ... Full text Cite

Single-breath Fractional Ventilation Derived From 129Xe MRI: Repeatability in Idiopathic Pulmonary Fibrosis

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Current methods for assessing ventilation heterogeneity via hyperpolarized 129Xe MRI generally rely on histogram-based techniques such as rescaling to arbitrary thresholds or image-base ... Full text Cite

Lung Volume Correction Increases Repeatability of 129Xe Gas Exchange MRI in IPF

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRATIONALE:A range of hyperpolarized 129Xe gas exchange MRI markers have been proposed to assess disease progression and therapy response in diverse cardiopulmonary conditions, including COPD and t ... Full text Cite

XeLHC: Initial Impressions From Hyperpolarized 129Xe MRI Measurements of Regional Lung Health in Participants from the Lung Health Cohort

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRATIONALE: The Lung Health Cohort (LHC) is an NIH-funded study to examine determinants of lung health in 4000 young adults (ages 25-35) across the United States. In this ancillary study, we are co ... Full text Cite

Assessment of Regional Ventilation by Hyperpolarized 129Xe MRI in Patients With Idiopathic Pulmonary Fibrosis and Asthma

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Pulmonary ventilation distribution is heterogeneous in health individuals, and it may worsen in lung diseases. Hyperpolarized 129Xe MRI is a novel technique that can be used to quantify ... Full text Cite

Same-session Repeatability of 129Xe MRI/MRS Measures of Gas Exchange in Idiopathic Pulmonary Fibrosis

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale. Patients with idiopathy pulmonary fibrosis (IPF) are known to have altered patterns of 129Xe gas exchange MRI and spectroscopy, including a reduced red blood cell to membrane ratio (RBC ... Full text Cite

129Xe Gas Exchange MRI in Obesity-associated Asthma: Clinical Correlates and Regional Patterns

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale. The complex interplay of factors contributing to the pathobiology of obesity-associated asthma is poorly understood. Advancing understanding of the unique disease mechanisms driving gas ... Full text Cite

Hyperpolarized129Xe MRI Membrane Uptake Associates With 12-month Changes in Lung Function in Patients With Idiopathic Pulmonary Fibrosis Initiating Therapy

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRATIONALE: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Antifibrotic therapies can slow lung function decline in patients with IPF, but reliable methods ... Full text Cite

Pulmonary Regional Differences Highlight Profibrotic Airway Epithelial Cell Signaling in Obese Asthma

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRationale: Obesity increases the severity of asthma and modifies airway pathobiology, contributing to lack of responsiveness to standard asthma therapies. The mechanisms driving altered lung funct ... Full text Cite

Combining hyperpolarized 129Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance.

Conference J Appl Physiol (1985) · March 1, 2025 Hyperpolarized 129Xe MRI/MRS enables quantitative mapping of function in lung airspaces, membrane tissue, and red blood cells (RBCs) within the pulmonary capillaries. The RBC signal also exhibits cardiogenic oscillations that are reduced in precapillary pu ... Full text Link to item Cite