Scholarly Works - Preprints
Preprint
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2026
Summary While a growing number of studies have linked environmental exposures and Parkinson’s disease (PD) 1–3 , the impact of many pesticides remains understudied 4,5 ; for example, neonicotinoids are the most used insecticides in the world, b ...
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Preprint
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November 3, 2025
Extracellular matrix (ECM) plays fundamental roles in animal development, regeneration, and disease. The difficulty of tagging endogenous matrix proteins in vertebrates has limited the understanding of ECM composition and dynamics in complex tissues. To vi ...
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Preprint
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May 3, 2025
Cell invasion through basement membrane (BM) is energetically intensive, and how an invading cell produces high ATP levels to power invasion is understudied. By generating 20 endogenously tagged mitochondrial proteins, we identified a specialized mitochond ...
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Preprint
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April 9, 2025
The quality of mitochondria inherited from the oocyte determines embryonic viability, metabolic health throughout progeny lifetime, and future generation endurance. High levels of endogenous reactive oxygen species and exogenous toxicants are threats to mi ...
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Preprint
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March 14, 2025
UNLABELLED: Cell invasion through basement membrane (BM) extracellular matrix barriers is important during organ development, immune cell trafficking, and cancer metastasis. Here we study an invasion event, anchor cell (AC) invasion, which occurs during Ca ...
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Preprint
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February 3, 2025
The quality of inherited mitochondria determines embryonic viability 1 , metabolic health during adulthood and future generation endurance. The oocyte is the source of all zygotic mitochondria 2 , and mitochondrial health is under strict developmental regu ...
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Preprint
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2025
Alport syndrome is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and eye abnormalities. Gene therapy for Alport syndrome has not yet been realized due to technical challenges, including effective transduction of target ...
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Preprint
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2024
The type IV collagen triple helix, composed of three ⍺-chains, is a core basement membrane (BM) component that assembles into a network within BMs. Endogenous tagging of all ⍺-chains with genetically encoded fluorophores has remained elusive, limiting o ...
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Preprint
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July 2023
Separate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withstand independent tissue movement. Yet, how cells ach ...
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Preprint
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June 12, 2023
AbstractSeparate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withsta ...
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Preprint
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May 11, 2023
AbstractSeparate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withsta ...
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Preprint
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2023
Background Diets high in saturated fat and sugar, termed ‘western diets’, have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s Disease (PD) is the second most prevalent ne ...
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https://orcid.org/0000-0002-4448-6917