David M. Tobin

Preprint · February 4, 2026 UNLABELLED: During infection, pathogenic mycobacteria reside within phagosomes of varying acidity based on the macrophage activation state. The ESX-1 secretion system [early secreted antigen 6 kilodaltons (ESAT-6) system-1] delivers protein virulence facto ... Full text Link to item Cite

Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis within Tuberculous Granulomas.

Preprint · April 27, 2025 Mycobacterial granulomas lie at the center of tuberculosis (TB) pathogenesis and represent a unique niche where infecting bacteria survive in nutrient-restricted conditions and in the face of a host immune response. The granuloma's necrotic core, where bac ... Full text Link to item Cite

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.

Preprint · April 1, 2025 Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB dise ... Full text Link to item Cite

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

Preprint · 2024 Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, ESX-1 (ESAT-6 system 1) secretion is crucial for ... Full text Cite

The EspN transcription factor is an infection-dependent regulator of the ESX-1 system in M. marinum.

Preprint · February 16, 2023 Full text Link to item Cite

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

Preprint · 2022 Full text Cite