David Samuel Warner
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Humans may sustain a variety of forms of acute central nervous system injury including ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection Laboratories is dedicated to examining the pathophysiology of acute brain and spinal cord injury with particular reference to disease states managed in the perioperative or neurointensive care environments. Rodent recovery models of cerebral ischemia, traumatic brain injury, cardiopulmonary bypass, subarachnoid hemorrhage, spinal cord ischemia, and perinatal hypoxia have been established with requisite control of relevant physiologic variables. Experimental protocols examine the response of brain to these insults and seek to define appropriate therapeutic interventions. Our work examines the role reactive oxygen species in CNS injury with emphasis on how pharmacologic or genetic variants modulate these processes. Effects of altered synthesis of superoxide dismutase and apolipoprotein E are investigated in transgenic/knock out mice. Outcome studies allow definition of efficacy of pharmacologic agents including superoxide dismutase mimetics, PARP-1 inhibitors, hepatocyte growth factor mimetics, recombinant apolipoprotein E and its peptide fragments, SNO-hemoglobin, and anesthetics on histologic and behavioral recovery from ischemic/traumatic insults. Recent focus has been on SUMOylation responses of neural tissue to ischemic stress. Neurochemical, immunohistochemical, molecular biologic, genomic, and proteomic techniques are used to define the mechanistic basis of observations made in outcome studies. Primary neuronal/glial cultures, organotypic hippocampal slices and immortalized transfected human cell lines are used investigate mechanistic interactions between pharmacologic agents and metabolic stresses.
Current Appointments & Affiliations
- Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Anesthesiology, Neuroanesthesia, Anesthesiology 2012
- Professor of Anesthesiology, Anesthesiology, Neuroanesthesia, Anesthesiology 1994
- Vice-Chair, Research, Anesthesiology, Clinical Science Departments 2001
- Chief, Division of Basic Sciences, Anesthesiology, Clinical Science Departments 2007
- Professor in Neurobiology, Neurobiology, Basic Science Departments 1994
- Professor of Surgery, Surgery, Section of Surgical Disciplines 1994
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011
Contact Information
- 303 Research Dr., 134 Sands Buildign, Durham, NC 27710
- Box 3094 Med Ctr, Durham, NC 27710
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david.warner@duke.edu
(919) 684-6633
- Background
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Education, Training, & Certifications
- M.D., University of Wisconsin - Madison 1980
- Recognition
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Awards & Honors
- Award For Translational Research Mentoring. Duke University School of Medicine. 2015
- Award for Mentoring Excellence in Research. Foundation for Anesthesia Education and Research (American Society of Anesthesiologists). 2015
- Distinguished Alumnus Award for Achievement. University of Iowa Carver College of Medicine. 2015
- Distinguished Service Award. Society for Neurosciences In Anesthesiology and Critical Care. 2011
- Neuroscience Award. Azzociazione Per La Diffusione E L'Avanzamento Delle Neuroscienze Toscano. 2011
- Teacher Of The Year. Department of Anesthesiology, DUMC. 2011
- Excellence in Research. American Society of Anesthesiologists. October 2005
- Expertise
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Subject Headings
- Acid-Base Equilibrium
- Acidosis
- Acute Disease
- Adaptation, Physiological
- Adjuvants, Pharmaceutic
- Administration, Inhalation
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Aging
- Alfentanil
- Allosteric Regulation
- Allosteric Site
- Alzheimer Disease
- Ambulatory Surgical Procedures
- Amino Acid Sequence
- Amyloid beta-Peptides
- Analgesics
- Analgesics, Opioid
- Analysis of Variance
- Anesthesia
- Anesthesia Recovery Period
- Anesthesia, Conduction
- Anesthesia, General
- Anesthesia, Inhalation
- Anesthesia, Intravenous
- Anesthesia, Local
- Anesthesia, Spinal
- Anesthesiology
- Anesthetics
- Anesthetics, General
- Anesthetics, Inhalation
- Anesthetics, Intravenous
- Anesthetics, Local
- Aneurysm
- Animals
- Animals, Newborn
- Anoxia
- Anti-Arrhythmia Agents
- Anti-Inflammatory Agents
- Antibodies
- Anticoagulants
- Anticonvulsants
- Antiemetics
- Antihypertensive Agents
- Antioxidants
- Antipyrine
- Aorta
- Aortic Diseases
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoprotein E4
- Apolipoproteins E
- Apoptosis
- Aprotinin
- Area Under Curve
- Arginine
- Arterial Occlusive Diseases
- Arteriosclerosis
- Ascorbic Acid
- Asphyxia
- Asphyxia Neonatorum
- Astrocytes
- Astrocytoma
- Autonomic Nerve Block
- Autoradiography
- Avoidance Learning
- Awards and Prizes
- Basilar Artery
- Behavior, Animal
- Behavioral Symptoms
- Bicarbonates
- Bicuculline
- Binding Sites
- Biological Availability
- Biological Markers
- Biomimetic Materials
- Biomimetics
- Bleeding Time
- Blood Flow Velocity
- Blood Gas Analysis
- Blood Glucose
- Blood Pressure
- Blood Volume
- Blood-Brain Barrier
- Blotting, Western
- Body Temperature
- Body Temperature Regulation
- Body Water
- Brachial Plexus
- Brain
- Brain Chemistry
- Brain Damage, Chronic
- Brain Diseases
- Brain Edema
- Brain Injuries
- Brain Ischemia
- Brain Mapping
- Brain Neoplasms
- Bupivacaine
- Calcium
- Calcium Channel Blockers
- Calibration
- Capillary Permeability
- Carbon Dioxide
- Carbon Radioisotopes
- Cardiac Glycosides
- Cardiopulmonary Bypass
- Cardiopulmonary Resuscitation
- Cardiovascular Agents
- Carotid Arteries
- Carotid Artery, Internal
- Caspases
- Catalase
- Catalysis
- Catecholamines
- Catheterization
- Cell Count
- Cell Death
- Cell Hypoxia
- Cell Lineage
- Cell Movement
- Cell Survival
- Cells, Cultured
- Central Nervous System
- Central Nervous System Diseases
- Cerebellar Diseases
- Cerebellum
- Cerebral Arterial Diseases
- Cerebral Arteries
- Cerebral Cortex
- Cerebral Hemorrhage
- Cerebral Infarction
- Cerebral Ventricles
- Cerebrospinal Fluid
- Cerebrovascular Circulation
- Cerebrovascular Disorders
- Cervical Vertebrae
- Chelating Agents
- Chemokines
- Chemotaxis, Leukocyte
- Child
- Circle of Willis
- Clinical Competence
- Clinical Protocols
- Clinical Trials as Topic
- Cognition
- Cold Temperature
- Colloids
- Constriction
- Convulsants
- Cortical Spreading Depression
- Corticosterone
- Craniocerebral Trauma
- Craniotomy
- Creatinine
- Culture Media
- Culture Techniques
- Cytokines
- DNA Damage
- DNA Fragmentation
- Data Collection
- Death
- Deep Sedation
- Deferoxamine
- Dentate Gyrus
- Diabetes Mellitus
- Diabetes Mellitus, Experimental
- Digestive System Surgical Procedures
- Disease Models, Animal
- Disease Susceptibility
- Diuretics, Osmotic
- Dizocilpine Maleate
- Dose-Response Relationship, Drug
- Double-Blind Method
- Down-Regulation
- Droperidol
- Drowning
- Drug Administration Schedule
- Drug Antagonism
- Drug Delivery Systems
- Drug Evaluation, Preclinical
- Drug Interactions
- Drug Synergism
- Drug Therapy, Combination
- Elective Surgical Procedures
- Electrochemical Techniques
- Electrodes
- Electroencephalography
- Electrolytes
- Electrophysiology
- Emergency Medical Services
- Encephalitis
- Endocytosis
- Endopeptidases
- Endothelial Cells
- Endothelial Growth Factors
- Endothelium, Vascular
- Energy Metabolism
- Enoxaparin
- Enzyme-Linked Immunosorbent Assay
- Epinephrine
- Equipment Design
- Erythrocytes
- Ethers
- Excitatory Amino Acid Agonists
- Excitatory Amino Acid Antagonists
- Exploratory Behavior
- Extracellular Matrix
- Extracellular Space
- Extremities
- Factor Analysis, Statistical
- Female
- Fentanyl
- Ferric Compounds
- Fever
- Fibroblasts
- Fluid Therapy
- Flumazenil
- Fluorobenzenes
- Follow-Up Studies
- Free Radical Scavengers
- Freezing
- Functional Laterality
- GABA Agonists
- GABA Antagonists
- GABA-A Receptor Antagonists
- Ganglia, Sympathetic
- Ganglionic Blockers
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genotype
- Glial Fibrillary Acidic Protein
- Glioma
- Gliosis
- Glossopharyngeal Nerve
- Glucose
- Glutamic Acid
- Glutathione Peroxidase
- Glycine
- Growth Substances
- Guidelines as Topic
- Halothane
- Head Injuries, Closed
- Heart Arrest
- Heart Arrest, Induced
- Heart Rate
- Heat-Shock Proteins
- Hematocrit
- Hematoma
- Heme Oxygenase (Decyclizing)
- Hemiplegia
- Hemodilution
- Hemodynamics
- Hemoglobins
- Hernia, Inguinal
- Hippocampus
- History, 20th Century
- Homeostasis
- Humans
- Hydrogen Peroxide
- Hydrogen-Ion Concentration
- Hydrophobic and Hydrophilic Interactions
- Hydrostatic Pressure
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hyperbaric Oxygenation
- Hypercapnia
- Hyperglycemia
- Hyperthyroidism
- Hypotension
- Hypotension, Controlled
- Hypothermia
- Hypothermia, Induced
- Hypoxia, Brain
- Hypoxia-Ischemia, Brain
- Image Enhancement
- Image Processing, Computer-Assisted
- Immunity, Innate
- Immunohistochemistry
- In Situ Hybridization
- Infant, Newborn
- Infarction, Middle Cerebral Artery
- Inflammation
- Infratentorial Neoplasms
- Infusion Pumps
- Infusions, Intravenous
- Injections, Intra-Articular
- Injections, Intravenous
- Injections, Intraventricular
- Injections, Spinal
- Injections, Subcutaneous
- Insulin
- Intensive Care
- Intercellular Signaling Peptides and Proteins
- Intracranial Aneurysm
- Intracranial Embolism
- Intracranial Embolism and Thrombosis
- Intracranial Hemorrhages
- Intracranial Pressure
- Intraoperative Care
- Intraoperative Complications
- Intubation, Intratracheal
- Ion Channels
- Ischemia
- Ischemic Attack, Transient
- Ischemic Preconditioning
- Isoflurane
- Isomerism
- Isotonic Solutions
- Kainic Acid
- Ketamine
- Kidney
- Kidney Function Tests
- L-Lactate Dehydrogenase
- Laminectomy
- Laryngeal Nerves
- Laser-Doppler Flowmetry
- Learning
- Length of Stay
- Leukoencephalopathies
- Leukopenia
- Lidocaine
- Linear Models
- Lipid Peroxidation
- Locomotion
- Lower Extremity
- Lumbosacral Plexus
- Macromolecular Substances
- Macrophages
- Magnesium
- Magnesium Chloride
- Magnesium Sulfate
- Magnetic Resonance Imaging
- Male
- Malignant Hyperthermia
- Malondialdehyde
- Manganese
- Mannitol
- Matrix Metalloproteinase 9
- Maze Learning
- Membrane Potentials
- Meningeal Neoplasms
- Meningioma
- Mepivacaine
- Mesencephalon
- Metalloporphyrins
- Methohexital
- Metyrapone
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Neurologic Mutants
- Mice, Transgenic
- Microdialysis
- Microelectrodes
- Microglia
- Micropore Filters
- Microscopy
- Microscopy, Fluorescence
- Microspheres
- Middle Aged
- Middle Cerebral Artery
- Mitochondria
- Models, Animal
- Models, Biological
- Models, Cardiovascular
- Models, Statistical
- Molecular Mimicry
- Molecular Structure
- Monitoring, Intraoperative
- Morphine
- Motor Activity
- Motor Neurons
- Muscimol
- Muscle Relaxation
- Muscle, Smooth, Vascular
- N-Methylaspartate
- NF-kappa B
- NG-Nitroarginine Methyl Ester
- Narcotics
- Nausea
- Necrosis
- Neoplasm Transplantation
- Neoplasms
- Neostriatum
- Nerve Block
- Nerve Degeneration
- Nerve Growth Factors
- Nerve Tissue Proteins
- Nervous System
- Nervous System Diseases
- Neural Stem Cells
- Neurodegenerative Diseases
- Neurogenesis
- Neuroglia
- Neurologic Examination
- Neurons
- Neuroprotective Agents
- Neuropsychological Tests
- Neurosurgical Procedures
- Neurotoxins
- Neurotransmitter Uptake Inhibitors
- Nicardipine
- Nicotine
- Nicotinic Antagonists
- Nimodipine
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Nitric Oxide Synthase Type III
- Nitrites
- Nitrogen
- Nitrous Oxide
- Norepinephrine
- Nylons
- Ondansetron
- Organ Culture Techniques
- Oropharynx
- Orthopedic Procedures
- Osmolar Concentration
- Osmotic Pressure
- Oxidants
- Oxidation-Reduction
- Oxidative Stress
- Oxides
- Oxycodone
- Oxygen
- Oxygen Consumption
- Oxyhemoglobins
- Pain
- Pain Measurement
- Pain, Postoperative
- Parietal Lobe
- Partial Pressure
- Patient Discharge
- Patient Satisfaction
- Patient Selection
- Pentobarbital
- Peptide Fragments
- Peptides
- Perception
- Periodicals as Topic
- Peripheral Nerves
- Peripheral Nervous System Diseases
- Pharmaceutical Preparations
- Physicians
- Pia Mater
- Pilot Projects
- Placebos
- Plaque, Amyloid
- Plasma Substitutes
- Plasma Volume
- Platelet-Derived Growth Factor
- Pneumocephalus
- Poly(ADP-ribose) Polymerases
- Pons
- Porphyrins
- Postoperative Care
- Postoperative Complications
- Postoperative Nausea and Vomiting
- Postoperative Period
- Postural Balance
- Potassium
- Potassium Channels
- Predictive Value of Tests
- Pregnancy
- Pregnanolone
- Premedication
- Progesterone
- Prognosis
- Propofol
- Proprioception
- Prospective Studies
- Proteins
- Psoas Muscles
- Psychomotor Performance
- Publishing
- Pulmonary Alveoli
- Pyramidal Tracts
- Questionnaires
- Rabbits
- Radiation Injuries, Experimental
- Radiation Tolerance
- Radiation-Protective Agents
- Random Allocation
- Randomized Controlled Trials as Topic
- Rats
- Rats, Inbred F344
- Rats, Inbred SHR
- Rats, Inbred Strains
- Rats, Sprague-Dawley
- Rats, Wistar
- Reaction Time
- Reactive Oxygen Species
- Receptors, AMPA
- Receptors, GABA-A
- Receptors, Glutamate
- Receptors, Glycine
- Receptors, N-Methyl-D-Aspartate
- Receptors, Opioid
- Recombinant Proteins
- Recovery of Function
- Reference Values
- Regional Blood Flow
- Regression Analysis
- Reperfusion
- Reperfusion Injury
- Reproducibility of Results
- Research
- Research Design
- Restraint, Physical
- Resuscitation
- Retention (Psychology)
- Retrospective Studies
- Rewarming
- Risk
- Risk Factors
- Rotarod Performance Test
- S100 Proteins
- SUMO-1 Protein
- Saline Solution, Hypertonic
- Sciatic Nerve
- Seizures
- Sensation
- Sensory Thresholds
- Serine Proteinase Inhibitors
- Serotonin
- Sex Characteristics
- Signal Transduction
- Simvastatin
- Single-Blind Method
- Small Ubiquitin-Related Modifier Proteins
- Sodium Chloride
- Solubility
- Species Specificity
- Specific Gravity
- Spectrophotometry, Ultraviolet
- Spinal Cord
- Spinal Cord Compression
- Spinal Cord Injuries
- Spinal Cord Ischemia
- Spinal Diseases
- Spine
- Status Epilepticus
- Stem Cell Transplantation
- Stress, Physiological
- Stroke
- Structure-Activity Relationship
- Subarachnoid Hemorrhage
- Sufentanil
- Superoxide Dismutase
- Supratentorial Neoplasms
- Surgical Instruments
- Surgical Procedures, Operative
- Survival Analysis
- Swimming
- Telencephalon
- Temperature
- Tetracaine
- Thalamus
- Thiopental
- Thoracic Vertebrae
- Thoracotomy
- Thrombosis
- Thyroidectomy
- Time
- Time Factors
- Tissue Distribution
- Tissue Fixation
- Tissue Plasminogen Activator
- Tomography, X-Ray Computed
- Trachea
- Transcription, Genetic
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Translational Medical Research
- Treatment Outcome
- Trimethaphan
- Tritium
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
- Tyrosine
- Ubiquitin-Conjugating Enzymes
- Ubiquitins
- Ultrasonography, Doppler, Transcranial
- United States
- Upper Extremity
- Vascular Diseases
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Vascular Patency
- Vascular Surgical Procedures
- Vasospasm, Intracranial
- Visual Perception
- Volatilization
- Vomiting
- Wakefulness
- Water
- Water-Electrolyte Balance
- X-Rays
- Xanthine Oxidase
- Xenon
- von Willebrand Factor
- Research
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Selected Grants
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health 2016 - 2021
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2021
- Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke awarded by BioMimetix JV LLC 2019 - 2020
- Translating Endogenous Vascular Protective Cascades into Therapy for Aneurysmal Subarachnoid Hemorrhage awarded by Washington University in St. Louis 2015 - 2020
- Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health 2016 - 2020
- Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health 2015 - 2018
- The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society 2014 - 2018
- STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health 2015 - 2017
- Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham 2013 - 2016
- Multidisciplinary Neonatal Training Grant awarded by National Institutes of Health 2010 - 2015
- Fe porphyrin-based Redox Modulator in Experimental Stroke Outcome awarded by National Institutes of Health 2013 - 2015
- S-Nitrosylated Hemoglobin and Ischemic Brain Injury awarded by National Institutes of Health 2009 - 2012
- Ethyl Nitrite and Subarachnoid Hemorrhage awarded by National Institutes of Health 2008 - 2011
- Shutdown of Translation and Ischemia/Stroke-Induced Cell Death awarded by National Institutes of Health 2008 - 2010
- Defining the Learning Curve in Research Trials awarded by National Institutes of Health 2004 - 2009
- Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser awarded by Air Force Office of Scientific Research 2000 - 2008
- Anesthetics, GABA and the Injured Brain awarded by National Institutes of Health 2003 - 2008
- Trangenic Mouse Model of Alzheimer's Disease awarded by National Institutes of Health 2003 - 2006
- Role of Extracellular Oxygen Radicals in Ischemic Brain awarded by National Institutes of Health 2000 - 2005
- Same awarded by National Institutes of Health 2000 - 2003
- Apolipoprotein E and the Ischemic Brain awarded by National Institutes of Health 1998 - 2002
- same awarded by National Institutes of Health 1996 - 2001
- Integrated Training In Anesthesiology Research awarded by National Institutes of Health 1996 - 1999
- Cerebral Ischemia: Minimizing Damage During Anesthesia awarded by National Institutes of Health 1997 - 1999
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External Relationships
- BioMimetix Pharmaceutical, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Li, Litao, Artak Tovmasyan, Huaxin Sheng, Bin Xu, Romulo S. Sampaio, Julio S. Reboucas, David S. Warner, Ines Batinic-Haberle, and Ivan Spasojevic. “Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+.” Antioxidants (Basel) 9, no. 6 (June 1, 2020). https://doi.org/10.3390/antiox9060467.Full Text Link to Item
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Ma, Shuang, Dongmei Chu, Litao Li, Jennifer A. Creed, Yu-Mi Ryang, Huaxin Sheng, Wei Yang, David S. Warner, Dennis A. Turner, and Ulrike Hoffmann. “Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome.” Crit Care Med 47, no. 8 (August 2019): e693–99. https://doi.org/10.1097/CCM.0000000000003809.Full Text Link to Item
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Terrando, Niccolò, and David S. Warner. “Xenon for traumatic brain injury: a noble step forward and a wet blanket.” Br J Anaesth 123, no. 1 (July 2019): 9–11. https://doi.org/10.1016/j.bja.2019.04.004.Full Text Link to Item
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Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.Full Text Link to Item
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Xie, Yongqiu, Yi-Ju Li, Beilei Lei, Dawn Kernagis, Wen-Wei Liu, Ellen R. Bennett, Talagnair Venkatraman, et al. “Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.” Transl Stroke Res 10, no. 2 (April 2019): 231–39. https://doi.org/10.1007/s12975-018-0633-z.Full Text Link to Item
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Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.Full Text Link to Item
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Agarwal, Piyush K. “Editorial Comment.” J Urol 199, no. 2 (February 2018): 414–15. https://doi.org/10.1016/j.juro.2017.08.132.Full Text Link to Item
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Liu, Huaqin, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S. Warner, Wei Yang, and Huaxin Sheng. “Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.” Aging Dis 9, no. 1 (February 2018): 31–39. https://doi.org/10.14336/AD.2017.0221.Full Text Link to Item
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Idris, Ahamed H., Joost J. L. M. Bierens, Gavin D. Perkins, Volker Wenzel, Vinay Nadkarni, Peter Morley, David S. Warner, et al. “2015 revised Utstein-style recommended guidelines for uniform reporting of data from drowning-related resuscitation: An ILCOR advisory statement.” Resuscitation 118 (September 2017): 147–58. https://doi.org/10.1016/j.resuscitation.2017.05.028.Full Text Link to Item
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Idris, Ahamed H., Joost J. L. M. Bierens, Gavin D. Perkins, Volker Wenzel, Vinay Nadkarni, Peter Morley, David S. Warner, et al. “2015 Revised Utstein-Style Recommended Guidelines for Uniform Reporting of Data From Drowning-Related Resuscitation: An ILCOR Advisory Statement.” Circ Cardiovasc Qual Outcomes 10, no. 7 (July 2017). https://doi.org/10.1161/HCQ.0000000000000024.Full Text Link to Item
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Jiang, Meng, Shu Yu, Zhui Yu, Huaxin Sheng, Ying Li, Shuai Liu, David S. Warner, Wulf Paschen, and Wei Yang. “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.” Stroke 48, no. 6 (June 2017): 1646–54. https://doi.org/10.1161/STROKEAHA.117.016579.Full Text Link to Item
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Warner, David S., and Huaxin Sheng. “Anesthetic Neuroprotection? It's Complicated.” Anesthesiology 126, no. 4 (April 2017): 579–81. https://doi.org/10.1097/ALN.0000000000001535.Full Text Link to Item
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Yu, Zhui, Huaxin Sheng, Shuai Liu, Shengli Zhao, Christopher C. Glembotski, David S. Warner, Wulf Paschen, and Wei Yang. “Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.” J Cereb Blood Flow Metab 37, no. 3 (March 2017): 1069–79. https://doi.org/10.1177/0271678X16650218.Full Text Link to Item
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Zhang, Lin, Xiaozhi Liu, Huaxin Sheng, Shuai Liu, Ying Li, Julia Q. Zhao, David S. Warner, Wulf Paschen, and Wei Yang. “Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.” Neuroscience 343 (February 20, 2017): 190–212. https://doi.org/10.1016/j.neuroscience.2016.11.036.Full Text Link to Item
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Berger, Miles, Vikram Ponnusamy, Nathaniel Greene, Mary Cooter, Jacob W. Nadler, Allan Friedman, David L. McDonagh, et al. “The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.” Front Immunol 8 (2017): 1528. https://doi.org/10.3389/fimmu.2017.01528.Full Text Link to Item
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Taninishi, Hideki, Molly Pearlstein, Huaxin Sheng, Miwa Izutsu, Rafael E. Chaparro, Larry B. Goldstein, and David S. Warner. “Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat.” J Cereb Blood Flow Metab 36, no. 12 (December 2016): 2203–10. https://doi.org/10.1177/0271678X15616980.Full Text Link to Item
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Hoffmann, Ulrike, Huaxin Sheng, Cenk Ayata, and David S. Warner. “Anesthesia in Experimental Stroke Research.” Transl Stroke Res 7, no. 5 (October 2016): 358–67. https://doi.org/10.1007/s12975-016-0491-5.Full Text Link to Item
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Sasaki, Toshihiro, Ulrike Hoffmann, Motomu Kobayashi, Huaxin Sheng, Abdelkader Ennaceur, Frederick W. Lombard, and David S. Warner. “Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.” Neurocrit Care 25, no. 2 (October 2016): 293–305. https://doi.org/10.1007/s12028-016-0250-1.Full Text Link to Item
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Warner, David S., and William L. Lanier. “Michael M. Todd, M.D., Recipient of the 2016 Excellence in Research Award.” Anesthesiology, August 8, 2016. https://doi.org/10.1097/ALN.0000000000001291.Full Text Link to Item
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Lee, Han Kyu, Sehoon Keum, Huaxin Sheng, David S. Warner, Donald C. Lo, and Douglas A. Marchuk. “Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.” J Clin Invest 126, no. 8 (August 1, 2016): 2827–38. https://doi.org/10.1172/JCI84491.Full Text Link to Item
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Berger, Miles, Jacob W. Nadler, Allan Friedman, David L. McDonagh, Ellen R. Bennett, Mary Cooter, Wenjing Qi, et al. “The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.” J Alzheimers Dis 52, no. 4 (April 15, 2016): 1299–1310. https://doi.org/10.3233/JAD-151190.Full Text Open Access Copy Link to Item
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Eisenach, James C., David S. Warner, and Timothy T. Houle. “Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement.” Anesthesiology 124, no. 4 (April 2016): 763–65. https://doi.org/10.1097/ALN.0000000000001044.Full Text Link to Item
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Bierens, Joost J. L. M., Philippe Lunetta, Mike Tipton, and David S. Warner. “Physiology Of Drowning: A Review.” Physiology (Bethesda) 31, no. 2 (March 2016): 147–66. https://doi.org/10.1152/physiol.00002.2015.Full Text Link to Item
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Hsieh, Justin T., Beilei Lei, Huaxin Sheng, Talagnair Venkatraman, Christopher D. Lascola, David S. Warner, and Michael L. James. “Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.” Neuroendocrinology 103, no. 5 (2016): 518–30. https://doi.org/10.1159/000440883.Full Text Link to Item
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Ashcraft, Kathleen A., Mary-Keara Boss, Artak Tovmasyan, Kingshuk Roy Choudhury, Andrew N. Fontanella, Kenneth H. Young, Gregory M. Palmer, et al. “Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.” Int J Radiat Oncol Biol Phys 93, no. 4 (November 15, 2015): 892–900. https://doi.org/10.1016/j.ijrobp.2015.07.2283.Full Text Link to Item
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Hong, Jun, Vijaya Nandiwada, Victoria Jones, Miaomiao Lu, David S. Warner, Somnath Mukhopadhyay, and Huaxin Sheng. “CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery.” Neurosci Lett 597 (June 15, 2015): 19–24. https://doi.org/10.1016/j.neulet.2015.04.016.Full Text Link to Item
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Chaparro, Rafael E., Miwa Izutsu, Toshihiro Sasaki, Huaxin Sheng, Yi Zheng, Homa Sadeghian, Tao Qin, et al. “Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.” J Cereb Blood Flow Metab 35, no. 6 (June 2015): 1044–53. https://doi.org/10.1038/jcbfm.2015.23.Full Text Link to Item
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Taninishi, Hideki, Jin Yong Jung, Miwa Izutsu, Zhengfeng Wang, Huaxin Sheng, and David S. Warner. “A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat.” J Neurosci Methods 241 (February 15, 2015): 111–20. https://doi.org/10.1016/j.jneumeth.2014.12.006.Full Text Link to Item
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Feix, James A., C Andrew Peery, Tong J. Gan, David S. Warner, Michael L. James, Ali Zomorodi, and David L. McDonagh. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.” Springerplus 4 (2015): 350. https://doi.org/10.1186/s40064-015-1126-0.Full Text Open Access Copy Link to Item
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Lombard, Frederick, Gavin W. Britz, and David S. Warner. “Simvastatin in subarachnoid haemorrhage: beyond the short-term.” Lancet Neurol 13, no. 11 (November 2014): 1073. https://doi.org/10.1016/S1474-4422(14)70229-7.Full Text Link to Item
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Warner, David S., Michael L. James, Daniel T. Laskowitz, and Eelco F. Wijdicks. “Translational research in acute central nervous system injury: lessons learned and the future.” Jama Neurol 71, no. 10 (October 2014): 1311–18. https://doi.org/10.1001/jamaneurol.2014.1238.Full Text Link to Item
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Lei, Beilei, Huaxin Sheng, Haichen Wang, Christopher D. Lascola, David S. Warner, Daniel T. Laskowitz, and Michael L. James. “Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.” J Vis Exp, no. 89 (July 3, 2014). https://doi.org/10.3791/51439.Full Text Link to Item
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Wang, Ruihua, Jun Hong, Miaomiao Lu, Jessica E. Neil, Michael P. Vitek, Xiaozhi Liu, David S. Warner, Fengqiao Li, and Huaxin Sheng. “ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.” J Neurosci Res 92, no. 7 (July 2014): 884–92. https://doi.org/10.1002/jnr.23371.Full Text Link to Item
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Sheng, Huaxin, Raphael E. Chaparro, Toshihiro Sasaki, Miwa Izutsu, Robert D. Pearlstein, Artak Tovmasyan, and David S. Warner. “Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2437–64. https://doi.org/10.1089/ars.2013.5413.Full Text Link to Item
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Berger, M., B. Philips-Bute, J. Guercio, T. J. Hopkins, M. L. James, C. O. Borel, D. S. Warner, and D. L. McDonagh. “A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement.” Curr Med Res Opin 30, no. 2 (February 2014): 243–50. https://doi.org/10.1185/03007995.2013.855190.Full Text Link to Item
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Berger, Miles, David S. Warner, and David L. McDonagh. “Volatile anesthetic sedation during therapeutic hypothermia after cardiac arrest in the ICU: a journey of a thousand miles begins with a single step.” Crit Care Med 42, no. 2 (February 2014): 494–95. https://doi.org/10.1097/01.ccm.0000435689.93091.d0.Full Text Link to Item
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Ishida, Kazuyoshi, Miles Berger, Jacob Nadler, and David S. Warner. “Anesthetic neuroprotection: antecedents and an appraisal of preclinical and clinical data quality.” Curr Pharm Des 20, no. 36 (2014): 5751–65. https://doi.org/10.2174/1381612820666140204111701.Full Text Link to Item
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Lei, Beilei, Brian Mace, Hana N. Dawson, David S. Warner, Daniel T. Laskowitz, and Michael L. James. “Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.” Plos One 9, no. 7 (2014): e103969. https://doi.org/10.1371/journal.pone.0103969.Full Text Open Access Copy Link to Item
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Warner, David S., and William L. Lanier. “Mr. Piano Man: reflections on the life of physician, scientist, and humanitarian, William L. Young, MD (1954-2013).” J Neurosurg Anesthesiol 26, no. 1 (January 2014): 1–3. https://doi.org/10.1097/ANA.0000000000000006.Full Text Link to Item
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Bierens, Joost J. L. M., and David S. Warner. “Drowning resuscitation requires another state of mind.” Resuscitation 84, no. 11 (November 2013): 1467–69. https://doi.org/10.1016/j.resuscitation.2013.09.005.Full Text Link to Item
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Spasojevic, Ivan, Tin Weitner, Artak Tovmasyan, Huaxin Sheng, Sumitra Miriyala, David Leu, Zrinka Rajic, et al. “Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” Free Radical Biology and Medicine 65 (November 2013): S132–S132. https://doi.org/10.1016/j.freeradbiomed.2013.10.728.Full Text
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Tovmasyan, Artak, Tin Weitner, Huaxin Sheng, MiaoMiao Lu, Zrinka Rajic, David S. Warner, Ivan Spasojevic, Julio S. Reboucas, Ludmil Benov, and Ines Batinic-Haberle. “Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.” Inorg Chem 52, no. 10 (May 20, 2013): 5677–91. https://doi.org/10.1021/ic3012519.Full Text Link to Item
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Benner, Eric J., Dominic Luciano, Rebecca Jo, Khadar Abdi, Patricia Paez-Gonzalez, Huaxin Sheng, David S. Warner, Chunlei Liu, Cagla Eroglu, and Chay T. Kuo. “Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.” Nature 497, no. 7449 (May 16, 2013): 369–73. https://doi.org/10.1038/nature12069.Full Text Link to Item
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Weitner, Tin, Ivan Kos, Huaxin Sheng, Artak Tovmasyan, Julio S. Reboucas, Ping Fan, David S. Warner, Zeljko Vujaskovic, Ines Batinic-Haberle, and Ivan Spasojevic. “Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.” Free Radic Biol Med 58 (May 2013): 73–80. https://doi.org/10.1016/j.freeradbiomed.2013.01.006.Full Text Link to Item
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Yates, Robert B., Huaxin Sheng, Hiroaki Sakai, Daniel T. Kleven, Noelle A. DeSimone, Mark Stafford-Smith, and David S. Warner. “Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat.” J Cardiothorac Vasc Anesth 27, no. 1 (February 2013): 71–78. https://doi.org/10.1053/j.jvca.2012.06.012.Full Text Link to Item
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Benner, E. J., D. Luciano, R. Jo, K. Abdi, P. Paez-Gonzalez, H. Sheng, D. S. Warner, C. Liu, C. Eroglu, and C. T. Kuo. “Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.” Nature 497, no. 7449 (2013): 369–73. https://doi.org/10.1038/nature12069.Full Text
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Tovmasyan, Artak, Huaxin Sheng, Tin Weitner, Amanda Arulpragasam, Miaomiao Lu, David S. Warner, Zeljko Vujaskovic, Ivan Spasojevic, and Ines Batinic-Haberle. “Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.” Med Princ Pract 22, no. 2 (2013): 103–30. https://doi.org/10.1159/000341715.Full Text Link to Item
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Sheng, Siyuan P., Beilei Lei, Michael L. James, Christopher D. Lascola, Talaignair N. Venkatraman, Jin Yong Jung, Mervyn Maze, et al. “Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.” Anesthesiology 117, no. 6 (December 2012): 1262–75. https://doi.org/10.1097/ALN.0b013e3182746b81.Full Text Link to Item
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Topjian, Alexis A., Robert A. Berg, Joost J. L. M. Bierens, Christine M. Branche, Robert S. Clark, Hans Friberg, Cornelia W. E. Hoedemaekers, et al. “Brain resuscitation in the drowning victim.” Neurocrit Care 17, no. 3 (December 2012): 441–67. https://doi.org/10.1007/s12028-012-9747-4.Full Text Link to Item
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Indraswari, Fransisca, Haichen Wang, Beilei Lei, Michael L. James, Dawn Kernagis, David S. Warner, Hana N. Dawson, and Daniel T. Laskowitz. “Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.” J Neurotrauma 29, no. 7 (May 1, 2012): 1388–1400. https://doi.org/10.1089/neu.2011.2117.Full Text Link to Item
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Rajic, Zrinka, Artak Tovmasyan, Ivan Spasojevic, Huaxin Sheng, Miaomiao Lu, Alice M. Li, Edith B. Gralla, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.” Free Radic Biol Med 52, no. 9 (May 1, 2012): 1828–34. https://doi.org/10.1016/j.freeradbiomed.2012.02.006.Full Text Link to Item
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Sheng, Huaxin, Ivan Spasojevic, Hubert M. Tse, Jin Yong Jung, Jun Hong, Zhiquan Zhang, Jon D. Piganelli, Ines Batinic-Haberle, and David S. Warner. “Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.” J Pharmacol Exp Ther 338, no. 3 (September 2011): 906–16. https://doi.org/10.1124/jpet.110.176701.Full Text Link to Item
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Tovmasyan, Artak G., Zrinka Rajic, Ivan Spasojevic, Julio S. Reboucas, Xin Chen, Daniela Salvemini, Huaxin Sheng, David S. Warner, Ludmil Benov, and Ines Batinic-Haberle. “Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.” Dalton Trans 40, no. 16 (April 28, 2011): 4111–21. https://doi.org/10.1039/c0dt01321h.Full Text Link to Item
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Sheng, Huaxin, James D. Reynolds, Richard L. Auten, Ivan T. Demchenko, Claude A. Piantadosi, Jonathan S. Stamler, and David S. Warner. “Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage.” Stroke 42, no. 2 (February 2011): 471–76. https://doi.org/10.1161/STROKEAHA.110.600569.Full Text Link to Item
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Guinn, Nicole R., David L. McDonagh, Cecil O. Borel, David R. Wright, Ali R. Zomorodi, Ciaran J. Powers, David S. Warner, Arthur M. Lam, and Gavin W. Britz. “Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review.” J Neurosurg Anesthesiol 23, no. 1 (January 2011): 35–40. https://doi.org/10.1097/ANA.0b013e3181ef2b11.Full Text Link to Item
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Nguyen, Hoang P., Jonathan G. Zaroff, Emine O. Bayman, Adrian W. Gelb, Michael M. Todd, Bradley J. Hindman, and Bradley J. IHAST-MIDS and IHAST Investigators. “Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial.” Anesthesiology 113, no. 2 (August 2010): 327–42. https://doi.org/10.1097/ALN.0b013e3181dfd4f7.Full Text Link to Item
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Wang, Zhengfeng, Wei Yang, Gavin W. Britz, Frederick W. Lombard, David S. Warner, and Huaxin Sheng. “Development of a simplified spinal cord ischemia model in mice.” J Neurosci Methods 189, no. 2 (June 15, 2010): 246–51. https://doi.org/10.1016/j.jneumeth.2010.04.003.Full Text Link to Item
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Pearlstein, Robert D., Yoshinori Higuchi, Maria Moldovan, Kwame Johnson, Shiro Fukuda, Daila S. Gridley, James D. Crapo, David S. Warner, and James M. Slater. “Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain.” Int J Radiat Biol 86, no. 2 (February 2010): 145–63. https://doi.org/10.3109/09553000903419965.Full Text Link to Item
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Hindman, Bradley J., Emine O. Bayman, Wolfgang K. Pfisterer, James C. Torner, Michael M. Todd, and Michael M. IHAST Investigators. “No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial.” Anesthesiology 112, no. 1 (January 2010): 86–101. https://doi.org/10.1097/ALN.0b013e3181c5e28f.Full Text Link to Item
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Borgeat, Alain, Timothy J. Brennan, James C. Eisenach, Hugh C. Hemmings, Shiroh Isono, Judy R. Kersten, Eberhard Kochs, Bruno Riou, and David S. Warner. “2009 in Review.” Anesthesiology 111, no. 6 (December 1, 2009): 1192–96. https://doi.org/10.1097/aln.0b013e3181c1879b.Full Text
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Sheng, Huaxin, Wei Yang, Shiro Fukuda, Hubert M. Tse, Wulf Paschen, Kwame Johnson, Ines Batinic-Haberle, et al. “Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.” Free Radic Biol Med 47, no. 7 (October 1, 2009): 917–23. https://doi.org/10.1016/j.freeradbiomed.2009.05.039.Full Text Link to Item
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Takata, Ken, Huaxin Sheng, Cecil O. Borel, Daniel T. Laskowitz, David S. Warner, and Frederick W. Lombard. “Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.” J Neurosurg Anesthesiol 21, no. 4 (October 2009): 326–33. https://doi.org/10.1097/ANA.0b013e3181acfde7.Full Text Link to Item
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Wise-Faberowski, Lisa, Prairie Neeley Robinson, Sarah Rich, and David S. Warner. “Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition.” Anesth Analg 109, no. 1 (July 2009): 205–10. https://doi.org/10.1213/ane.0b013e3181a27e37.Full Text Link to Item
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Warner, David S., Joost J. L. M. Bierens, Stephen B. Beerman, and Laurence M. Katz. “Drowning: a cry for help.” Anesthesiology 110, no. 6 (June 2009): 1211–13. https://doi.org/10.1097/ALN.0b013e3181a4c3d3.Full Text Link to Item
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Todd, Michael M., Bradley J. Hindman, William R. Clarke, James C. Torner, Julie B. Weeks, Emine O. Bayman, Qian Shi, Christina M. Spofford, and Christina M. IHAST Investigators. “Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.” Neurosurgery 64, no. 5 (May 2009): 897–908. https://doi.org/10.1227/01.NEU.0000341903.11527.2F.Full Text Link to Item
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Wise-Faberowski, Lisa, David S. Warner, Ivan Spasojevic, and Ines Batinic-Haberle. “Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.” Free Radic Res 43, no. 4 (April 2009): 329–39. https://doi.org/10.1080/10715760902736283.Full Text Link to Item
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Mackensen, G Burkhard, David L. McDonagh, and David S. Warner. “Perioperative hypothermia: use and therapeutic implications.” J Neurotrauma 26, no. 3 (March 2009): 342–58. https://doi.org/10.1089/neu.2008.0596.Full Text Link to Item
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Pasternak, Jeffrey J., Diana G. McGregor, William L. Lanier, Darrell R. Schroeder, Deborah A. Rusy, Bradley Hindman, William Clarke, James Torner, Michael M. Todd, and Michael M. IHAST Investigators. “Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery.” Anesthesiology 110, no. 3 (March 2009): 563–73. https://doi.org/10.1097/ALN.0b013e318197ff81.Full Text Link to Item
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Warner, David S. “Filling in the blanks.” Anesthesiology 110, no. 1 (January 2009): 10–11. https://doi.org/10.1097/ALN.0b013e3181913ddc.Full Text Link to Item
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Eisenach, James C., Alain Borgeat, Zeljko J. Bosnjak, Timothy J. Brennan, Judy R. Kersten, Eberhard Kochs, Jerrold Lerman, David S. Warner, and Jeanine P. Wiener-Kronish. “2008 in review: advancing medicine in anesthesiology.” Anesthesiology 109, no. 6 (December 2008): 962–72. https://doi.org/10.1097/ALN.0b013e31818e4149.Full Text Link to Item
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Takata, Ken, Huaxin Sheng, Cecil O. Borel, Daniel T. Laskowitz, David S. Warner, and Frederick W. Lombard. “Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.” Exp Neurol 213, no. 2 (October 2008): 336–44. https://doi.org/10.1016/j.expneurol.2008.06.009.Full Text Link to Item
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Laskowitz, Daniel T., and David S. Warner. “The use of S100B as a biomarker in subarachnoid hemorrhage: clarity in its promise and limits.” Crit Care Med 36, no. 8 (August 2008): 2452–53. https://doi.org/10.1097/CCM.0b013e3181810457.Full Text Link to Item
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Yang, Wei, Huaxin Sheng, H Mayumi Homi, David S. Warner, and Wulf Paschen. “Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?” J Neurochem 106, no. 3 (August 2008): 989–99. https://doi.org/10.1111/j.1471-4159.2008.05404.x.Full Text Link to Item
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Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.” J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892–96. https://doi.org/10.1038/sj.jcbfm.9600601.Full Text Link to Item
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Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient global cerebral ischemia induces a massive increase in protein sumoylation.” J Cereb Blood Flow Metab 28, no. 2 (February 2008): 269–79. https://doi.org/10.1038/sj.jcbfm.9600523.Full Text Link to Item
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James, Michael Lucas, David S. Warner, and Daniel T. Laskowitz. “Preclinical models of intracerebral hemorrhage: a translational perspective.” Neurocrit Care 9, no. 1 (2008): 139–52. https://doi.org/10.1007/s12028-007-9030-2.Full Text Link to Item
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Laskowitz, Daniel T., and David S. Warner. “Statins in acute brain injury: getting the cart before the horse.” Neurocrit Care 8, no. 1 (2008): 3–5. https://doi.org/10.1007/s12028-007-9040-0.Full Text Link to Item
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McDonagh, David L., and David S. Warner. “Hypertonic saline for craniotomy?” Anesthesiology 107, no. 5 (November 2007): 689–91. https://doi.org/10.1097/01.anes.0000286923.77106.63.Full Text Link to Item
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Warner, David S. “Debra A. Schwinn, M.D., Recipient of the 2007 Excellence in Research Award.” Anesthesiology 107, no. 3 (September 1, 2007): 380–82. https://doi.org/10.1097/01.anes.0000279490.10778.6d.Full Text
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Fukuda, S., and D. S. Warner. “Cerebral protection.” Br J Anaesth 99, no. 1 (July 2007): 10–17. https://doi.org/10.1093/bja/aem140.Full Text Link to Item
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Wang, Haichen, John R. Lynch, Pingping Song, Hyuk-Jun Yang, Robert B. Yates, Brian Mace, David S. Warner, John R. Guyton, and Daniel T. Laskowitz. “Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.” Exp Neurol 206, no. 1 (July 2007): 59–69. https://doi.org/10.1016/j.expneurol.2007.03.031.Full Text Link to Item
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Wang, H., L. Durham, H. Dawson, P. Song, D. S. Warner, P. M. Sullivan, M. P. Vitek, and D. T. Laskowitz. “Corrigendum to "an apolipoprotein e-based therapeutic improves outcome and reduces alzheimer's disease pathology following closed head injury: Evidence of pharmacogenomic interaction". [Neuroscience 144 (2007) 1324-1333]{star, open} (DOI:10.1016/j.neuroscience.2006.11.017).” Neuroscience 146, no. 2 (May 11, 2007): 874. https://doi.org/10.1016/j.neuroscience.2007.01.044.Full Text
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Rice, Henry E., Edward W. Hsu, Huaxin Sheng, Debra A. Evenson, Alex J. Freemerman, Kristine M. Safford, James M. Provenzale, David S. Warner, and G Allan Johnson. “Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.” Ajr Am J Roentgenol 188, no. 4 (April 2007): 1101–8. https://doi.org/10.2214/AJR.06.0663.Full Text Link to Item
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Wang, H., L. Durham, H. Dawson, P. Song, D. S. Warner, P. M. Sullivan, M. P. Vitek, and D. T. Laskowitz. “An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.” Neuroscience 144, no. 4 (February 23, 2007): 1324–33. https://doi.org/10.1016/j.neuroscience.2006.11.017.Full Text Link to Item
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Bierens, J., R. Berg, P. Morley, D. Szpilman, and D. Warner. “Drowning,” January 1, 2007, 1088–1102. https://doi.org/10.1017/CBO9780511544828.063.Full Text
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Sakai, Hiroaki, Huaxin Sheng, Robert B. Yates, Kazuyoshi Ishida, Robert D. Pearlstein, and David S. Warner. “Isoflurane provides long-term protection against focal cerebral ischemia in the rat.” Anesthesiology 106, no. 1 (January 2007): 92–99. https://doi.org/10.1097/00000542-200701000-00017.Full Text Link to Item
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Warner, D. S., and J. T. A. Knape. “Brain resuscitation in the drowning victim task force on brain resuscitation,” December 1, 2006, 435–78. https://doi.org/10.1007/3-540-29656-5_8.Full Text
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Wise-Faberowski, Lisa, Robert D. Pearlstein, and David S. Warner. “NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine.” J Neurosurg Anesthesiol 18, no. 4 (October 2006): 240–46. https://doi.org/10.1097/00008506-200610000-00004.Full Text Link to Item
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Mesis, Rachel G., Haichen Wang, Frederick W. Lombard, Robert Yates, Michael P. Vitek, Cecil O. Borel, David S. Warner, and Daniel T. Laskowitz. “Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.” Neurosurg Focus 21, no. 3 (September 15, 2006): E4. https://doi.org/10.3171/foc.2006.21.3.4.Full Text Link to Item
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Wang, James K. T., Stuart Portbury, Mary Beth Thomas, Shawn Barney, Daniel J. Ricca, Dexter L. Morris, David S. Warner, and Donald C. Lo. “Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform.” Proc Natl Acad Sci U S A 103, no. 27 (July 5, 2006): 10461–66. https://doi.org/10.1073/pnas.0600930103.Full Text Link to Item
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Elsersy, Hazem, Javier Mixco, Huaxin Sheng, Robert D. Pearlstein, and David S. Warner. “Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.” Anesthesiology 105, no. 1 (July 2006): 81–90. https://doi.org/10.1097/00000542-200607000-00016.Full Text Link to Item
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McDonagh, David L., Idi N. Allen, John C. Keifer, and David S. Warner. “Induction of hypothermia after intraoperative hypoxic brain insult.” Anesth Analg 103, no. 1 (July 2006): 180–81. https://doi.org/10.1213/01.ane.0000221436.92700.8e.Full Text Link to Item
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Warner, David S., and Daniel T. Laskowitz. “Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer.” Anesthesiology 104, no. 4 (April 2006): 629–30. https://doi.org/10.1097/00000542-200604000-00002.Full Text Link to Item
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Freiberger, John J., Hagir B. Suliman, Huaxin Sheng, Jessica McAdoo, Claude A. Piantadosi, and David S. Warner. “A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.” Brain Res 1075, no. 1 (February 23, 2006): 213–22. https://doi.org/10.1016/j.brainres.2005.12.088.Full Text Link to Item
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Leinenweber, Stephen B., Huaxin Sheng, John R. Lynch, Haichen Wang, Ines Batinić-Haberle, Daniel T. Laskowitz, James D. Crapo, Robert D. Pearlstein, and David S. Warner. “Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.” Eur J Pharmacol 531, no. 1–3 (February 15, 2006): 126–32. https://doi.org/10.1016/j.ejphar.2005.12.031.Full Text Link to Item
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Hanks, R Kyle, Ricardo Pietrobon, Karen C. Nielsen, Susan M. Steele, Marcy Tucker, David S. Warner, Kathryn P. King, and Stephen M. Klein. “The effect of age on sciatic nerve block duration.” Anesth Analg 102, no. 2 (February 2006): 588–92. https://doi.org/10.1213/01.ane.0000189552.85175.db.Full Text Link to Item
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Faberowski, L. W., and D. S. Warner. “The effect of hypoxia on the developing brain: a function of age.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 25–35.
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Gao, Junling, Haichen Wang, Huaxin Sheng, John R. Lynch, David S. Warner, Lori Durham, Michael P. Vitek, and Daniel T. Laskowitz. “A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.” Neurocrit Care 4, no. 1 (2006): 25–31. https://doi.org/10.1385/NCC:4:1:025.Full Text Link to Item
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Sakai, H., R. Yates, H. Sheng, R. Pearlstein, and D. S. Warner. “Isoflurane provides sustained neuroprotection in rats subjected to focal ischemia.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 281. https://doi.org/10.1097/00008506-200610000-00030.Full Text
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Takata, K., F. W. Lombard, H. Sheng, D. Laskowitz, C. O. Borel, and D. S. Warner. “A rat model of cerebral vasospasm resulting in chronic motor and neurocognitive deficits following experimental sah.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 295. https://doi.org/10.1097/00008506-200610000-00059.Full Text
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Wang, Haichen, Junling Gao, Timothy F. Lassiter, David L. McDonagh, Huaxin Sheng, David S. Warner, John R. Lynch, and Daniel T. Laskowitz. “Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.” Neurocrit Care 5, no. 1 (2006): 71–78. https://doi.org/10.1385/NCC:5:1:71.Full Text Link to Item
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Klein, Stephen M., Holly Evans, Karen C. Nielsen, Marcy S. Tucker, David S. Warner, and Susan M. Steele. “Peripheral nerve block techniques for ambulatory surgery.” Anesth Analg 101, no. 6 (December 2005): 1663–76. https://doi.org/10.1213/01.ANE.0000184187.02887.24.Full Text Link to Item
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Lynch, John R., Haichen Wang, Matthew J. McGirt, James Floyd, Allan H. Friedman, Alexander L. Coon, Robert Blessing, et al. “Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.” Stroke 36, no. 9 (September 2005): 2024–26. https://doi.org/10.1161/01.STR.0000177879.11607.10.Full Text Link to Item
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Wise-Faberowski, Lisa, Haito Zhang, Richard Ing, Robert D. Pearlstein, and David S. Warner. “Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures.” Anesth Analg 101, no. 3 (September 2005): 651–57. https://doi.org/10.1213/01.ane.0000167382.79889.7c.Full Text Link to Item
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Abraini, Jacques H., Hélène N. David, Eric T. MacKenzie, and Marc Lemaire. “Postischemic nitrous oxide alone versus intraischemic nitrous oxide in the presence of isoflurane: what it may change for neuroprotection against cerebral stroke in the rat.” Anesth Analg 101, no. 2 (August 2005): 614. https://doi.org/10.1213/01.ANE.0000159020.86959.83.Full Text Link to Item
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Keifer, John C., Dimitar Dentchev, Kenneth Little, David S. Warner, Allan H. Friedman, and Cecil O. Borel. “A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping.” Anesth Analg 101, no. 2 (August 2005): 502–8. https://doi.org/10.1213/01.ANE.0000160533.51420.44.Full Text Link to Item
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McAdoo, Jessica D., David S. Warner, Ron N. Goldberg, Michael P. Vitek, Robert Pearlstein, and Daniel T. Laskowitz. “Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury.” Neurosci Lett 381, no. 3 (June 24, 2005): 305–8. https://doi.org/10.1016/j.neulet.2005.02.036.Full Text Link to Item
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Lynch, John R., Haichen Wang, Brian Mace, Stephen Leinenweber, David S. Warner, Ellen R. Bennett, Michael P. Vitek, Suzanne McKenna, and Daniel T. Laskowitz. “A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.” Exp Neurol 192, no. 1 (March 2005): 109–16. https://doi.org/10.1016/j.expneurol.2004.11.014.Full Text Link to Item
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McKee, J Andrew, Randall P. Brewer, Gary E. Macy, Barbara Phillips-Bute, Kurt A. Campbell, Cecil O. Borel, James D. Reynolds, and David S. Warner. “Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia.” Crit Care Med 33, no. 3 (March 2005): 661–66. https://doi.org/10.1097/01.ccm.0000156293.35868.b2.Full Text Link to Item
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Warner, D. S. “Anesthetics as neuroprotectants/neurotoxins.” Anesthesia and Analgesia 100, no. 3 SUPPL. (March 1, 2005): 95–99.
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McGirt, Matthew J., Graeme F. Woodworth, Gustavo Pradilla, Federico Legnani, David Warner, Rafael Tamargo, Richard Clatterbuck, John R. Lynch, and Daniel T. Laskowitz. “Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.” Clin Neurosurg 52 (2005): 371–78.Link to Item
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McKee, J Andrew, Randall P. Brewer, Gary E. Macy, Cecil O. Borel, James D. Reynolds, and David S. Warner. “Magnesium neuroprotection is limited in humans with acute brain injury.” Neurocrit Care 2, no. 3 (2005): 342–51. https://doi.org/10.1385/NCC:2:3:342.Full Text Link to Item
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Lascola, Christopher D., Allen W. Song, Timothy A. Haystead, David S. Warner, Katleen Verleysen, Tiffany A. Freed, and James M. Provenzale. “Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice.” Ajr Am J Roentgenol 183, no. 6 (December 2004): 1791–97. https://doi.org/10.2214/ajr.183.6.01831791.Full Text Link to Item
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Wise-Faberowski, Lisa, Mitsuo Aono, Robert D. Pearlstein, and David S. Warner. “Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity.” Anesth Analg 99, no. 6 (December 2004): 1708–14. https://doi.org/10.1213/01.ANE.0000136474.35627.FF.Full Text Link to Item
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Warner, David S. “Anesthetics provide limited but real protection against acute brain injury.” J Neurosurg Anesthesiol 16, no. 4 (October 2004): 303–7. https://doi.org/10.1097/00008506-200410000-00011.Full Text Link to Item
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Warner, David S., and Cecil O. Borel. “Treatment of traumatic brain injury: one size does not fit all.” Anesth Analg 99, no. 4 (October 2004): 1208–10. https://doi.org/10.1213/01.ANE.0000139930.04010.0D.Full Text Link to Item
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Yokoo, Noriko, Huaxin Sheng, Javier Mixco, H Mayumi Homi, Robert D. Pearlstein, and David S. Warner. “Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.” Anesth Analg 99, no. 3 (September 2004): 896–903. https://doi.org/10.1213/01.ANE.0000132973.32387.8B.Full Text Link to Item
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Sheng, Huaxin, Ivan Spasojevic, David S. Warner, and Ines Batinic-Haberle. “Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy.” Neurosci Lett 366, no. 2 (August 12, 2004): 220–25. https://doi.org/10.1016/j.neulet.2004.05.050.Full Text Link to Item
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Warner, David S., Huaxin Sheng, and Ines Batinić-Haberle. “Oxidants, antioxidants and the ischemic brain.” J Exp Biol 207, no. Pt 18 (August 2004): 3221–31. https://doi.org/10.1242/jeb.01022.Full Text Link to Item
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Abraini, Jacques H., Hélène N. David, Olivier Nicole, Eric T. MacKenzie, Alain Buisson, and Marc Lemaire. “Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration.” Anesthesiology 101, no. 1 (July 2004): 260–61. https://doi.org/10.1097/00000542-200407000-00049.Full Text Link to Item
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Homi, H Mayumi, Noriko Yokoo, Daqing Ma, David S. Warner, Nicholas P. Franks, Mervyn Maze, and Hilary P. Grocott. “Neuroprotection by Nitrous Oxide and Xenon and Its Relation to Minimum Alveolar Concentration.” Anesthesiology 101, no. 1 (July 1, 2004): 261–261. https://doi.org/10.1097/00000542-200407000-00050.Full Text
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Elsersy, Hazem, Huaxin Sheng, John R. Lynch, Maria Moldovan, Robert D. Pearlstein, and David S. Warner. “Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.” Anesthesiology 100, no. 5 (May 2004): 1160–66. https://doi.org/10.1097/00000542-200405000-00018.Full Text Link to Item
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Sheng, Huaxin, Haichen Wang, Hercilia M. Homi, Ivan Spasojevic, Ines Batinic-Haberle, Robert D. Pearlstein, and David S. Warner. “A no-laminectomy spinal cord compression injury model in mice.” J Neurotrauma 21, no. 5 (May 2004): 595–603. https://doi.org/10.1089/089771504774129928.Full Text Link to Item
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Klein, S. “Reply to Dr. Paqueron.” Regional Anesthesia and Pain Medicine 29, no. 2 (April 2004): 173–74. https://doi.org/10.1016/j.rapm.2004.01.003.Full Text
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Paqueron, Xavier, and Marc E. Gentili. “Assessing phantom limb sensations... and the library?” Reg Anesth Pain Med 29, no. 2 (March 2004): 172–73. https://doi.org/10.1016/j.rapm.2003.12.005.Full Text Link to Item
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Warner, David S. “Perioperative neuroprotection: are we asking the right questions?” Anesth Analg 98, no. 3 (March 2004): 563–65. https://doi.org/10.1213/01.ane.0000111213.71914.54.Full Text Link to Item
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Lee, Yoonki, Mitsuo Aono, Daniel Laskowitz, David S. Warner, and Robert D. Pearlstein. “Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity.” Neurochem Int 44, no. 2 (January 2004): 107–18. https://doi.org/10.1016/s0197-0186(03)00112-8.Full Text Link to Item
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Warner, David S. “Pharmacologic protection from ischemic neuronal injury.” J Neurosurg Anesthesiol 16, no. 1 (January 2004): 95–97. https://doi.org/10.1097/00008506-200401000-00020.Full Text Link to Item
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Lynch, John R., Wen Tang, Haichen Wang, Michael P. Vitek, Ellen R. Bennett, Patrick M. Sullivan, David S. Warner, and Daniel T. Laskowitz. “APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.” J Biol Chem 278, no. 49 (December 5, 2003): 48529–33. https://doi.org/10.1074/jbc.M306923200.Full Text Link to Item
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Homi, H Mayumi, Javier M. Mixco, Huaxin Sheng, Hilary P. Grocott, Robert D. Pearlstein, and David S. Warner. “Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.” Anesthesiology 99, no. 5 (November 2003): 1145–51. https://doi.org/10.1097/00000542-200311000-00022.Full Text Link to Item
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Homi, H Mayumi, Noriko Yokoo, Daqing Ma, David S. Warner, Nicholas P. Franks, Mervyn Maze, and Hilary P. Grocott. “The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice.” Anesthesiology 99, no. 4 (October 2003): 876–81. https://doi.org/10.1097/00000542-200310000-00020.Full Text Link to Item
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Klein, Stephen M., Dragan Dimitrov, Susan M. Steele, Karen C. Nielsen, David S. Warner, Aliki Martin, and Ricardo Pietrobon. “Altered perceptions after upper and lower extremity blocks: an initial investigation.” Reg Anesth Pain Med 28, no. 5 (September 2003): 433–38. https://doi.org/10.1016/s1098-7339(03)00233-5.Full Text Link to Item
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Bickler, Philip E., David S. Warner, Greg Stratmann, and Jennifer A. Schuyler. “gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures.” Anesth Analg 97, no. 2 (August 2003): 564–71. https://doi.org/10.1213/01.ane.0000068880.82739.7b.Full Text Link to Item
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Klein, Stephen M., Susan M. Steele, Karen C. Nielsen, Ricardo Pietrobon, David S. Warner, Aliki Martin, and Roy A. Greengrass. “The difficulties of ambulatory interscalene and intra-articular infusions for rotator cuff surgery: a preliminary report.” Can J Anaesth 50, no. 3 (March 2003): 265–69. https://doi.org/10.1007/BF03017796.Full Text Link to Item
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Warner, D. S. “Anesthesia for craniotomy.” Anesthesia and Analgesia 96, no. 3 (March 1, 2003): 107–13.Link to Item
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Borel, Cecil O., Andy McKee, Augusto Parra, Michael M. Haglund, Amy Solan, Vikas Prabhakar, Huaxin Sheng, David S. Warner, and Laura Niklason. “Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.” Stroke 34, no. 2 (February 2003): 427–33.Link to Item
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Aono, M., E. R. Bennett, K. S. Kim, J. R. Lynch, J. Myers, R. D. Pearlstein, D. S. Warner, and D. T. Laskowitz. “Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.” Neuroscience 116, no. 2 (2003): 437–45. https://doi.org/10.1016/s0306-4522(02)00709-1.Full Text Link to Item
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Petrozza, P. H., and D. S. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 15, no. 4 (January 1, 2003): 1. https://doi.org/10.1097/00008506-200310000-00012.Full Text
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Warner, D. S., and P. H. Petrozza. “Journal club.” Journal of Neurosurgical Anesthesiology 15, no. 2 (January 1, 2003): 1. https://doi.org/10.1097/00008506-200304000-00015.Full Text
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Warner, D. S., and P. H. Petrozza. “The impact of provider volume on mortality after intracranial tumor resection.” Journal of Neurosurgical Anesthesiology 15, no. 3 (January 1, 2003): 290. https://doi.org/10.1097/00008506-200307000-00022.Full Text
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Warner, D. S., and P. H. Petrozza. “Journal club.” Journal of Neurosurgical Anesthesiology 15, no. 1 (January 1, 2003): 1. https://doi.org/10.1097/00008506-200301000-00014.Full Text
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Ross, Aron D., Huaxin Sheng, David S. Warner, Claude A. Piantadosi, Ines Batinic-Haberle, Brian J. Day, and James D. Crapo. “Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.” Free Radic Biol Med 33, no. 12 (December 15, 2002): 1657–69. https://doi.org/10.1016/s0891-5849(02)01140-1.Full Text Link to Item
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McGirt, Matthew J., John R. Lynch, Augusto Parra, Huaxin Sheng, Robert D. Pearlstein, Daniel T. Laskowitz, Dale A. Pelligrino, and David S. Warner. “Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.” Stroke 33, no. 12 (December 2002): 2950–56. https://doi.org/10.1161/01.str.0000038986.68044.39.Full Text Link to Item
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Sheng, Huaxin, Ines Batinc-Haberle, and David S. Warner. “Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.” Drug News Perspect 15, no. 10 (December 2002): 654–65. https://doi.org/10.1358/dnp.2002.15.10.740236.Full Text Link to Item
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Joshi, Girish P., David S. Warner, Rebecca S. Twersky, and Lee A. Fleisher. “A comparison of the remifentanil and fentanyl adverse effect profile in a multicenter phase IV study.” J Clin Anesth 14, no. 7 (November 2002): 494–99. https://doi.org/10.1016/s0952-8180(02)00404-x.Full Text Link to Item
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McGirt, Matthew J., John R. Lynch, Robert Blessing, David S. Warner, Allan H. Friedman, and Daniel T. Laskowitz. “Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.” Neurosurgery 51, no. 5 (November 2002): 1128–34. https://doi.org/10.1097/00006123-200211000-00005.Full Text Link to Item
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Bowler, Russell P., Huaxin Sheng, Jan J. Enghild, Robert D. Pearlstein, David S. Warner, and James D. Crapo. “A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.” Free Radic Biol Med 33, no. 8 (October 15, 2002): 1141–52. https://doi.org/10.1016/s0891-5849(02)01008-0.Full Text Link to Item
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Aono, Mitsuo, Yoonki Lee, Elfrida R. Grant, Robert A. Zivin, Robert D. Pearlstein, David S. Warner, Ellen R. Bennett, and Daniel T. Laskowitz. “Apolipoprotein E protects against NMDA excitotoxicity.” Neurobiol Dis 11, no. 1 (October 2002): 214–20. https://doi.org/10.1006/nbdi.2002.0541.Full Text Link to Item
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Sheng, Huaxin, Jan J. Enghild, Russell Bowler, Manisha Patel, Ines Batinić-Haberle, Carla L. Calvi, Brian J. Day, Robert D. Pearlstein, James D. Crapo, and David S. Warner. “Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.” Free Radic Biol Med 33, no. 7 (October 1, 2002): 947–61. https://doi.org/10.1016/s0891-5849(02)00979-6.Full Text Link to Item
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Klein, Stephen M., Ricardo Pietrobon, Karen C. Nielsen, Susan M. Steele, David S. Warner, Joseph A. Moylan, W Steve Eubanks, and Roy A. Greengrass. “Paravertebral somatic nerve block compared with peripheral nerve blocks for outpatient inguinal herniorrhaphy.” Reg Anesth Pain Med 27, no. 5 (September 2002): 476–80. https://doi.org/10.1053/rapm.2002.35147.Full Text Link to Item
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McGirt, Matthew J., Augusto Parra, Huaxin Sheng, Yoshinori Higuchi, Tim D. Oury, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.” Stroke 33, no. 9 (September 2002): 2317–23. https://doi.org/10.1161/01.str.0000027207.67639.1e.Full Text Link to Item
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Lockhart, Ellen M., David S. Warner, Robert D. Pearlstein, Donald H. Penning, Saeed Mehrabani, and Rose-Mary Boustany. “Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture.” Neurosci Lett 328, no. 1 (August 2, 2002): 33–36. https://doi.org/10.1016/s0304-3940(02)00448-2.Full Text Link to Item
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McGirt, M. J., J. R. Lynch, H. X. Sheng, R. Pearlstein, D. T. Laskowitz, D. A. Pelligrino, and D. S. Warner. “Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates cerebral vasospasm after subarachnoid hemorrhage in the mouse via augmentation of endothelial nitric oxide synthase.” Neurosurgery 51, no. 2 (August 1, 2002): 580–580.Link to Item
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Zauner, Alois, Wilson P. Daugherty, M Ross Bullock, and David S. Warner. “Brain oxygenation and energy metabolism: part I-biological function and pathophysiology.” Neurosurgery 51, no. 2 (August 2002): 289–301.Link to Item
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Parra, Augusto, Matthew J. McGirt, Huaxin Sheng, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.” Neurol Res 24, no. 5 (July 2002): 510–16. https://doi.org/10.1179/016164102101200276.Full Text Link to Item
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Sato, Yukie, Daniel T. Laskowitz, Ellen R. Bennett, Mark F. Newman, David S. Warner, and Hilary P. Grocott. “Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?” Anesth Analg 94, no. 6 (June 2002): 1389–94. https://doi.org/10.1097/00000539-200206000-00003.Full Text Link to Item
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Wainwright, Mark S., Huaxin Sheng, Yukie Sato, G Burkhard Mackensen, Robert P. Steffen, Robert D. Pearlstein, and David S. Warner. “Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.” Am J Physiol Heart Circ Physiol 282, no. 5 (May 2002): H1863–70. https://doi.org/10.1152/ajpheart.00863.2001.Full Text Link to Item
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Lynch, J. R., M. J. McGirt, D. A. Pelligrino, D. T. Laskowitz, H. X. Sheng, and D. S. Warner. “Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage in mice.” Neurology 58, no. 7 (April 9, 2002): A367–A367.Link to Item
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Fabling, Jennifer M., Tong J. Gan, Habib E. El-Moalem, David S. Warner, and Cecil O. Borel. “A randomized, double-blind comparison of ondansetron versus placebo for prevention of nausea and vomiting after infratentorial craniotomy.” J Neurosurg Anesthesiol 14, no. 2 (April 2002): 102–7. https://doi.org/10.1097/00008506-200204000-00003.Full Text Link to Item
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Leinenweber, S. B., H. X. Sheng, J. Lynch, I. Batinic-Haberle, D. Laskowitz, and D. S. Warner. “Effects of a metalloporphyrin catalytic antioxidant in a murine model of closed head injury.” Pediatric Research 51, no. 4 (April 1, 2002): 48A-48A.Link to Item
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Batinic-Haberle, I., I. Spasojevic, H. X. Sheng, D. S. Warner, and I. Fridovich. “Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/traumatic injuries of central nervous system.” Free Radical Biology and Medicine 33 (January 1, 2002): S236–37.Link to Item
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Batinic-Haberle, I., I. Spasojevic, H. X. Sheng, D. S. Warner, and I. Fridovich. “Development of potent Mn(III) N-alkylpyridylporphyrin-based catalytic antioxidants for treating ischemic/raumatic injuries of central nervous system.” Free Radical Biology and Medicine 33 (January 1, 2002): S125–26.Link to Item
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Klein, Stephen M., Karen C. Nielsen, Roy A. Greengrass, David S. Warner, Aliki Martin, and Susan M. Steele. “Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine.” Anesth Analg 94, no. 1 (January 2002): 65–70. https://doi.org/10.1097/00000539-200201000-00012.Full Text Link to Item
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Klein, Stephen M., Ricardo Pietrobon, Karen C. Nielsen, David S. Warner, Roy A. Greengrass, and Susan M. Steele. “Peripheral nerve blockade with long-acting local anesthetics: a survey of the Society for Ambulatory Anesthesia.” Anesth Analg 94, no. 1 (January 2002): 71–76. https://doi.org/10.1097/00000539-200201000-00013.Full Text Link to Item
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Lynch, John R., Jose A. Pineda, Duncan Morgan, Lin Zhang, David S. Warner, Helen Benveniste, and Daniel T. Laskowitz. “Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema.” Ann Neurol 51, no. 1 (January 2002): 113–17. https://doi.org/10.1002/ana.10098.Full Text Link to Item
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McGirt, M. J., A. Parra, H. X. Sheng, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Attenuation of cerebral vasospasm following subarachnoid hemorrhage in mice over-expressing extracellular superoxide dismutase.” Stroke 33, no. 1 (January 1, 2002): 380–380.Link to Item
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Warner, D. S., H. X. Sheng, R. D. Pearlstein, C. Calvi, and J. D. Crapo. “AEOL 10150, a metalloporphyrin catalytic antioxidant, reduces injury from focal ischemia in the rat and mouse.” Free Radical Biology and Medicine 33 (January 1, 2002): S126–27.Link to Item
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Warner, D. S., and P. H. Petrozza. “Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin c, mediates potent cerebroprotection in experimental stroke.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 82. https://doi.org/10.1097/00008506-200201000-00017.Full Text
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Warner, D. S., and P. H. Petrozza. “Journal club.” Journal of Neurosurgical Anesthesiology 14, no. 3 (January 1, 2002): 1. https://doi.org/10.1097/00008506-200207000-00012.Full Text
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Warner, D. S., and P. H. Petrozza. “Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: a clinical, prospective, randomized, controlled study.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 86. https://doi.org/10.1097/00008506-200201000-00023.Full Text
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Warner, D. S., and P. H. Petrozza. “Mechanisms of intracerebral hemorrhage after carotid endarterectomy.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 166. https://doi.org/10.1097/00008506-200204000-00021.Full Text
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Warner, D. S., and P. H. Petrozza. “Safety of perioperative minidose heparin in patients undergoing brain tumor surgery: a prospective, randomized double-blind study.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 161. https://doi.org/10.1097/00008506-200204000-00014.Full Text
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Warner, D. S., and P. H. Petrozza. “Blocks at the wrist provide effective anesthesia for carpal tunnel release.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Treatment window for hypothermia in brain injury.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Computed tomography and magnetic resonance imagining of mild head injury: is it appropriate to classify patients with glasgow coma scale score 13 to 15 as “mild injury”?” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Neurosurgical procedures in jehovah's witnesses: an increased risk?” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “The use of central venous cannulae in neuroanesthesia.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Aneurysmal sah: cognitive outcome and structural damage after clipping or coiling.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 83. https://doi.org/10.1097/00008506-200201000-00019.Full Text
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Warner, D. S., and P. H. Petrozza. “Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma patients: a prospective study.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 85. https://doi.org/10.1097/00008506-200201000-00022.Full Text
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Warner, D. S., and P. H. Petrozza. “Clinical factors associated with unexpected critical care management and prolonged hospitalization after elective cervical spine surgery.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Endovascular versus surgical treatment in patients with carotid stenosis in the carotid and vertebral artery transluminal angioplasty study (cavatas): a randomised trial.” Journal of Neurosurgical Anesthesiology 14, no. 1 (January 1, 2002): 1.
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Warner, D. S., and P. H. Petrozza. “Journal club.” Journal of Neurosurgical Anesthesiology 14, no. 4 (January 1, 2002): 1. https://doi.org/10.1097/00008506-200210000-00009.Full Text
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Warner, D. S., and P. H. Petrozza. “Remote cerebellar hemorrhage after supratentorial surgery.” Journal of Neurosurgical Anesthesiology 14, no. 2 (January 1, 2002): 167. https://doi.org/10.1097/00008506-200204000-00023.Full Text
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Mackensen, G. B., Y. Sato, B. Nellgård, J. Pineda, M. F. Newman, D. S. Warner, and H. P. Grocott. “Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat.” Anesthesiology 95, no. 6 (December 2001): 1485–91. https://doi.org/10.1097/00000542-200112000-00031.Full Text Link to Item
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McDaniel, B., H. Sheng, D. S. Warner, L. W. Hedlund, and H. Benveniste. “Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study.” Neuroimage 14, no. 6 (December 2001): 1244–55. https://doi.org/10.1006/nimg.2001.0934.Full Text Link to Item
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Fleisher, L. A., S. Hogue, M. Colopy, R. S. Twersky, D. S. Warner, B. D. Jamerson, K. J. Tuman, P. S. Glass, and M. F. Roizen. “Does functional ability in the postoperative period differ between remifentanil- and fentanyl-based anesthesia?” J Clin Anesth 13, no. 6 (September 2001): 401–6. https://doi.org/10.1016/s0952-8180(01)00291-4.Full Text Link to Item
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Klein, S. M., K. C. Nielsen, A. Martin, W. White, D. S. Warner, S. M. Steele, K. P. Speer, and R. A. Greengrass. “Interscalene brachial plexus block with continuous intraarticular infusion of ropivacaine.” Anesth Analg 93, no. 3 (September 2001): 601–5. https://doi.org/10.1097/00000539-200109000-00015.Full Text Link to Item
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Kudo, M., M. Aono, Y. Lee, G. Massey, R. D. Pearlstein, and D. S. Warner. “Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures.” Anesthesiology 95, no. 3 (September 2001): 756–65. https://doi.org/10.1097/00000542-200109000-00031.Full Text Link to Item
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Twersky, R. S., B. Jamerson, D. S. Warner, L. A. Fleisher, and S. Hogue. “Hemodynamics and emergence profile of remifentanil versus fentanyl prospectively compared in a large population of surgical patients.” J Clin Anesth 13, no. 6 (September 2001): 407–16. https://doi.org/10.1016/s0952-8180(01)00292-6.Full Text Link to Item
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Mackensen, G. B., M. Patel, H. Sheng, C. L. Calvi, I. Batinic-Haberle, B. J. Day, L. P. Liang, et al. “Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.” J Neurosci 21, no. 13 (July 1, 2001): 4582–92.Link to Item
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Pineda, J. A., M. Aono, H. Sheng, J. Lynch, J. C. Wellons, D. T. Laskowitz, R. D. Pearlstein, R. Bowler, J. Crapo, and D. S. Warner. “Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse.” J Neurotrauma 18, no. 6 (June 2001): 625–34. https://doi.org/10.1089/089771501750291864.Full Text Link to Item
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Kudo, M., M. Aono, Y. Lee, G. Massey, R. D. Pearlstein, and D. S. Warner. “Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures.” Anesthesiology 94, no. 2 (February 2001): 303–212. https://doi.org/10.1097/00000542-200102000-00021.Full Text Link to Item
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Grocott, H. P., G. B. Mackensen, M. F. Newman, and D. S. Warner. “Neurological injury during cardiopulmonary bypass in the rat.” Perfusion 16, no. 1 (January 2001): 75–81. https://doi.org/10.1177/026765910101600111.Full Text Link to Item
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Lam, A. M., and D. S. Warner. “Opiates, intracranial pressure, and autoregulation.” Anesthesiology 94, no. 1 (January 2001): 177–78. https://doi.org/10.1097/00000542-200101000-00035.Full Text Link to Item
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Parra, A., M. J. McGirt, H. X. Sheng, R. D. Pearlstein, D. T. Laskowitz, and D. S. Warner. “Effects of extracellular superoxide dismutase on arterial vascular structural changes after acute subarachnoid hemorrhage in the mouse.” Stroke 32, no. 1 (January 1, 2001): 359–359.Link to Item
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Ross, A. D., D. S. Warner, H. X. Sheng, C. A. Piantadosi, B. J. Day, and J. D. Crapo. “Species-specific hemodynamic effects of metalloporphyrin SOD mimetics.” Free Radical Biology and Medicine 31 (January 1, 2001): S96–S96.Link to Item
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Warner, D. S. “Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 348. https://doi.org/10.1097/00008506-200110000-00024.Full Text
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Warner, D. S. “Can airway complications following multilevel anterior cervical surgery be avoided?” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 1. https://doi.org/10.1097/00008506-200110000-00018.Full Text
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Warner, D. S. “Identifying the more patent nostril before nasotracheal intubation.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 1. https://doi.org/10.1097/00008506-200110000-00021.Full Text
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Warner, D. S. “The influence of apolipoprotein e genotype on outcome after spontaneous subarachnoid hemorrhage: a preliminary study.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 345. https://doi.org/10.1097/00008506-200110000-00019.Full Text
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Warner, D. S. “Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 347. https://doi.org/10.1097/00008506-200110000-00022.Full Text
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Warner, D. S. “Cervical spine motion during intubation: efficacy of stabilization maneuvers in the setting of complete segmental instability.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 1. https://doi.org/10.1097/00008506-200110000-00020.Full Text
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Warner, D. S. “Glycine antagonist in neuroprotection for patients with acute stroke. gain americas: a randomized controlled trial.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 1. https://doi.org/10.1097/00008506-200110000-00023.Full Text
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Warner, D. S. “Lack of effect of induction of hypothermia after acute brain injury.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 1. https://doi.org/10.1097/00008506-200110000-00016.Full Text
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Warner, D. S. “Long-term propofol infusion and cardiac failure in adult patients with head injuries.” Journal of Neurosurgical Anesthesiology 13, no. 4 (January 1, 2001): 344. https://doi.org/10.1097/00008506-200110000-00017.Full Text
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Warner, D. S., H. X. Sheng, R. Bowler, J. Enghild, M. Patel, and J. D. Crapo. “Effects of metalloporphyrin catalytic antioxidants on rodent focal ischemic brain damage.” Free Radical Biology and Medicine 31 (January 1, 2001): S134–S134.Link to Item
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Klein, S. M., S. A. Grant, R. A. Greengrass, K. C. Nielsen, K. P. Speer, W. White, D. S. Warner, and S. M. Steele. “Interscalene brachial plexus block with a continuous catheter insertion system and a disposable infusion pump.” Anesth Analg 91, no. 6 (December 2000): 1473–78. https://doi.org/10.1097/00000539-200012000-00033.Full Text Link to Item
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Statler, K. D., P. M. Kochanek, C. E. Dixon, H. L. Alexander, D. S. Warner, R. S. Clark, S. R. Wisniewski, et al. “Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats.” J Neurotrauma 17, no. 12 (December 2000): 1179–89. https://doi.org/10.1089/neu.2000.17.1179.Full Text Link to Item
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Joshi, G. P., B. D. Jamerson, M. F. Roizen, L. Fleisher, R. S. Twersky, D. S. Warner, and M. Colopy. “Is there a learning curve associated with the use of remifentanil?” Anesth Analg 91, no. 5 (November 2000): 1049–55. https://doi.org/10.1097/00000539-200011000-00002.Full Text Link to Item
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Mackensen, G. B., B. Nellgârd, M. Kudo, H. Sheng, R. D. Pearlstein, and D. S. Warner. “Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.” Anesthesiology 93, no. 4 (October 2000): 1102–6. https://doi.org/10.1097/00000542-200010000-00035.Full Text Link to Item
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Kudo, M., Y. Lee, G. W. Massey, D. S. Warner, and R. D. Pearlstein. “Effects of volatile anesthetics on NMDA excitotoxicity in primary mixed neuronal/glial cultures.” Anesthesiology 93, no. 3A (September 1, 2000): U188–U188.Link to Item
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Mackensen, G. B., M. Patel, J. D. Crapo, I. Batinic-Haberle, and D. S. Warner. “Neuroprotection from delayed post-ischemic administration of a metalloporphyrin catalytic antioxidant in the rat.” Anesthesiology 93, no. 3A (September 1, 2000): U186–U186.Link to Item
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Fabling, J. M., T. J. Gan, H. E. El-Moalem, D. S. Warner, and C. O. Borel. “A randomized, double-blinded comparison of ondansetron, droperidol, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy.” Anesth Analg 91, no. 2 (August 2000): 358–61. https://doi.org/10.1097/00000539-200008000-00023.Full Text Link to Item
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Nellgård, B., G. B. Mackensen, J. Pineda, J. C. Wellons, R. D. Pearlstein, and D. S. Warner. “Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.” Anesthesiology 93, no. 2 (August 2000): 431–36. https://doi.org/10.1097/00000542-200008000-00022.Full Text Link to Item
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Wellons, John C., Huaxin Sheng, Jose Pineda, Gary W. Massey, Robert D. Pearlstein, David S. Warner, and Daniel T. Laskowitz. “813 Intracerebral Infusion of Human Recombinant Apolipoprotein E3 Reduces Global Ischemic Brain Injury in Apolipoprotein E Deficient Mice.” Neurosurgery 47, no. 2 (August 1, 2000): 532. https://doi.org/10.1097/00006123-200008000-00161.Full Text Link to Item
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Balakrishnan, G., P. Raudzens, S. K. Samra, K. Song, J. A. Boening, V. Bosek, B. D. Jamerson, and D. S. Warner. “A comparison of remifentanil and fentanyl in patients undergoing surgery for intracranial mass lesions.” Anesth Analg 91, no. 1 (July 2000): 163–69. https://doi.org/10.1097/00000539-200007000-00030.Full Text Link to Item
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Hogue, S. L., P. R. Reese, M. Colopy, L. A. Fleisher, K. J. Tuman, R. S. Twersky, D. S. Warner, and B. Jamerson. “Assessing a tool to measure patient functional ability after outpatient surgery.” Anesth Analg 91, no. 1 (July 2000): 97–106. https://doi.org/10.1097/00000539-200007000-00019.Full Text Link to Item
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Nellgård, B., G. B. Mackensen, G. Massey, R. D. Pearlstein, and D. S. Warner. “The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.” Anesth Analg 91, no. 1 (July 2000): 145–51. https://doi.org/10.1097/00000539-200007000-00027.Full Text Link to Item
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Wellons, J. C., H. Sheng, D. T. Laskowitz, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia.” Brain Res 868, no. 1 (June 16, 2000): 14–21. https://doi.org/10.1016/s0006-8993(00)02216-2.Full Text Link to Item
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Sheng, H., M. Kudo, G. B. Mackensen, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia.” Exp Neurol 163, no. 2 (June 2000): 392–98. https://doi.org/10.1006/exnr.2000.7363.Full Text Link to Item
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Warner, D. S. “Neuroanesthesia 2000.” Anesth Analg 90, no. 5 (May 2000): 1238–40. https://doi.org/10.1097/00000539-200005000-00049.Full Text Link to Item
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Warner, D. S. “Isoflurane neuroprotection: a passing fantasy, again?” Anesthesiology 92, no. 5 (May 2000): 1226–28.Link to Item
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Mackensen, G. B., H. P. Grocott, J. Pineda, B. Nellgard, M. F. Newman, and D. S. Warner. “Neurologic and neurocognitive dysfunction following cardiopulmonary bypass in the rat.” Anesthesia and Analgesia 90, no. 4 (April 1, 2000): SCA36–SCA36.Link to Item
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Mackensen, G. B., B. Nellgård, S. Sarraf-Yazdi, F. Dexter, R. P. Steffen, H. P. Grocott, and D. S. Warner. “Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat.” Brain Res 853, no. 1 (January 17, 2000): 15–21. https://doi.org/10.1016/s0006-8993(99)02212-x.Full Text Link to Item
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Veltkamp, R., D. S. Warner, F. Domoki, A. D. Brinkhous, J. F. Toole, and D. W. Busija. “Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats.” Brain Res 853, no. 1 (January 17, 2000): 68–73. https://doi.org/10.1016/s0006-8993(99)02250-7.Full Text Link to Item
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Li, P. A., A. Shuaib, H. Miyashita, Q. P. He, B. K. Siesjö, and D. S. Warner. “Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.” Stroke 31, no. 1 (January 2000): 183–92. https://doi.org/10.1161/01.str.31.1.183.Full Text Link to Item
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Warner, D. S. “Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia - Editorial comment.” Stroke 31, no. 1 (January 1, 2000): 191–92.Link to Item
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Nellgård, B. M., Y. Miura, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “Effect of intracerebral norepinephrine depletion on outcome from severe forebrain ischemia in the rat.” Brain Res 847, no. 2 (November 20, 1999): 262–69. https://doi.org/10.1016/s0006-8993(99)02059-4.Full Text Link to Item
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Nellgård, B., G. B. Mackensen, S. Sarraf-Yazdi, Y. Miura, R. Pearlstein, and D. S. Warner. “Pre-ischemic depletion of brain norepinephrine decreases infarct size in normothermic rats exposed to transient focal cerebral ischemia.” Neurosci Lett 275, no. 3 (November 19, 1999): 167–70. https://doi.org/10.1016/s0304-3940(99)00743-0.Full Text Link to Item
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Warner, D. S. “Experience with remifentanil in neurosurgical patients.” Anesth Analg 89, no. 4 Suppl (October 1999): S33–39. https://doi.org/10.1097/00000539-199910001-00007.Full Text Link to Item
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Warner, D. S. “Experience with remifentanil in neurosurgical patients.” Anesthesia and Analgesia 89, no. 4 (October 1, 1999): S33–39.Link to Item
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Fabling, J. M., J. Guy, C. O. Borel, D. S. Warner, and T. J. Gan. “Ondansetron, droperidol, placebo: Prospective, randomized, double-blind comparison of postoperative nausea & vomiting in supra-tentorial craniotomy.” Anesthesiology 91, no. 3A (September 1, 1999): U172–U172.Link to Item
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Grocott, H. P., G. B. Mackensen, R. D. Pearlstein, M. F. Newman, and D. S. Warner. “Neurologic outcome in a recovery model of cardiopulmonary bypass in the rat.” Anesthesiology 91, no. 3A (September 1, 1999): U328–U328.Link to Item
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Kudo, M., Y. Lee, G. Massey, R. D. Perlstein, and D. S. Warner. “Isoflurane and halothane reduce neuronal/glial injury from iron induced oxidative stress.” Anesthesiology 91, no. 3A (September 1, 1999): U345–U345.Link to Item
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Mackensen, G. B., C. L. Calvi, J. D. Crapo, R. D. Pearlstein, and D. S. Warner. “Superoxide dismutase (SOD) mimetic improves outcome from focal but not global cerebral ischemia in the rat.” Anesthesiology 91, no. 3A (September 1, 1999): U368–U368.Link to Item
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Mackensen, G. B., H. P. Grocott, J. A. Pineda, M. F. Newman, and D. S. Warner. “Cardiopulmonary bypass in the rat: The differential effects of hematocrit on tissue water content.” Anesthesiology 91, no. 3A (September 1, 1999): U340–U340.Link to Item
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Sheng, H., T. C. Brady, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse.” Neurosci Lett 267, no. 1 (May 21, 1999): 13–16. https://doi.org/10.1016/s0304-3940(99)00316-x.Full Text Link to Item
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Sarraf-Yazdi, S., H. Sheng, H. P. Grocott, R. D. Bart, R. D. Pearlstein, R. P. Steffen, and D. S. Warner. “Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat.” Brain Res 826, no. 2 (May 1, 1999): 172–80. https://doi.org/10.1016/s0006-8993(99)01233-0.Full Text Link to Item
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Sheng, H., D. T. Laskowitz, G. B. Mackensen, M. Kudo, R. D. Pearlstein, and D. S. Warner. “Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.” Stroke 30, no. 5 (May 1999): 1118–24. https://doi.org/10.1161/01.str.30.5.1118.Full Text Link to Item
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Grocott, H. P., G. B. Mackensen, J. Burnett, R. Pearlstein, and D. S. Warner. “A recovery model of cardiopulmonary bypass in the rat.” Anesthesia and Analgesia 88, no. 4 (April 1, 1999): U93–U93.Link to Item
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Mackensen, G. B., B. Nellgard, S. Sarraf-Yazdi, F. Dexter, R. P. Steffen, H. P. Grocott, and D. S. Warner. “Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from focal cerebral ischemia in the rat.” Anesthesia and Analgesia 88, no. 4 (April 1, 1999): U99–U99.Link to Item
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Miura, Y., G. B. Mackensen, B. Nellgård, R. D. Pearlstein, R. D. Bart, F. Dexter, and D. S. Warner. “Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.” Anesth Analg 88, no. 4 (April 1999): 787–92. https://doi.org/10.1097/00000539-199904000-00020.Full Text Link to Item
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Sheng, H., D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Characterization of a recovery global cerebral ischemia model in the mouse.” J Neurosci Methods 88, no. 1 (April 1, 1999): 103–9. https://doi.org/10.1016/s0165-0270(99)00018-7.Full Text Link to Item
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Mackensen, G. B., B. Nellgård, Y. Miura, C. T. Chu, F. Dexter, R. D. Pearlstein, and D. S. Warner. “Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat.” Anesthesiology 90, no. 3 (March 1999): 873–81. https://doi.org/10.1097/00000542-199903000-00031.Full Text Link to Item
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Grocott, H. P., H. Sheng, Y. Miura, S. Sarraf-Yazdi, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “The effects of aprotinin on outcome from cerebral ischemia in the rat.” Anesth Analg 88, no. 1 (January 1999): 1–7. https://doi.org/10.1097/00000539-199901000-00001.Full Text Link to Item
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Sarraf-Yazdi, S., H. Sheng, A. D. Brinkhous, R. D. Pearlstein, and D. S. Warner. “Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat.” J Neurosurg Anesthesiol 11, no. 1 (January 1999): 31–36. https://doi.org/10.1097/00008506-199901000-00006.Full Text Link to Item
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Sheng, H., R. D. Bart, T. D. Oury, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia.” Neuroscience 88, no. 1 (January 1999): 185–91. https://doi.org/10.1016/s0306-4522(98)00208-5.Full Text Link to Item
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Statler, K. D., P. M. Kochanek, C. E. Dixon, H. L. Alexander, D. S. Warner, R. S. B. Clark, S. R. Wisniewski, L. W. Jenkins, D. W. Marion, and P. J. Safar. “Isoflurane improves long-term neurologic outcome compared to fentanyl after traumatic brain injury in rats.” Critical Care Medicine 27, no. 12 SUPPL. (January 1, 1999). https://doi.org/10.1097/00003246-199912001-00063.Full Text
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Klein, S. M., R. A. Greengrass, S. M. Steele, F. J. D’Ercole, K. P. Speer, D. H. Gleason, E. R. DeLong, and D. S. Warner. “A comparison of 0.5% bupivacaine, 0.5% ropivacaine, and 0.75% ropivacaine for interscalene brachial plexus block.” Anesth Analg 87, no. 6 (December 1998): 1316–19. https://doi.org/10.1097/00000539-199812000-00019.Full Text Link to Item
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Warner, D. S. “Anaesthesia for carotid endarterectomy: General anaesthesia.” European Journal of Anaesthesiology, Supplement 15, no. SUPPL. 17 (December 1, 1998): 51–52.
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Reid, R. W., and D. S. Warner. “Pro: arguments for use of barbiturates in infants and children undergoing deep hypothermic circulatory arrest.” J Cardiothorac Vasc Anesth 12, no. 5 (October 1998): 591–94. https://doi.org/10.1016/s1053-0770(98)90108-2.Full Text Link to Item
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Mackensen, G. B., B. Nellgard, Y. Miura, F. Dexter, R. Pearlstein, and D. S. Warner. “Sympathetic ganglionic blockade masks positive effect of isoflurane on histologic outcome from near-complete cerebral ischemia in rats.” Anesthesiology 89, no. 3A (September 1, 1998): U747–U747.Link to Item
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Miura, Y., G. B. Mackensen, B. Nellgard, R. D. Pearlstein, and D. S. Warner. “Effects of anesthetic agents on concentrations of plasma and brain catecholamines during near-complete and incomplete cerebral ischemia.” Anesthesiology 89, no. 3A (September 1, 1998): U748–U748.Link to Item
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Nellgard, B. M. G., Y. Miura, G. B. Mackenesn, R. Pearlstein, and D. S. Warner. “Pretreatment with DSP-4 inhibits brain but not plasma release of catecholamines during global cerebral ischemia and does not improve neuronal outcome.” Anesthesiology 89, no. 3A (September 1, 1998): U748–U748.Link to Item
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Sarraf-Yazdi, S., H. Sheng, H. P. Grocott, R. D. Pearlstein, R. P. Steffen, and D. S. Warner. “Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine (MK-801) on infarct size following focal cerebral ischemia in conscious rats.” Anesthesiology 89, no. 3A (September 1, 1998): U747–U747.Link to Item
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Warner, D. S., B. D. Jamerson, G. Balakrishnan, J. Boening, V. Bosek, P. Raudzens, S. Samra, and K. Song. “Real-world comparison of fentanyl versus remifentanil based anesthesia for craniotomy.” Anesthesiology 89, no. 3A (September 1, 1998): U324–U324.Link to Item
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Warner, David S., and Franklin Dexter. “Is Lack of Statistical Power Always Evidence of Lack of Effect?” Anesthesiology 89, no. 3 (September 1998): 799–799. https://doi.org/10.1097/00000542-199809000-00047.Full Text
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Bart, R. D., H. Sheng, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia.” Neuroreport 9, no. 11 (August 3, 1998): 2615–20. https://doi.org/10.1097/00001756-199808030-00035.Full Text Link to Item
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Grocott, H. P., R. D. Bart, H. Sheng, Y. Miura, R. Steffen, R. D. Pearlstein, and D. S. Warner. “Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.” Stroke 29, no. 8 (August 1998): 1650–55. https://doi.org/10.1161/01.str.29.8.1650.Full Text Link to Item
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Miura, Y., H. P. Grocott, R. D. Bart, R. D. Pearlstein, F. Dexter, and D. S. Warner. “Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat.” Anesthesiology 89, no. 2 (August 1998): 391–400. https://doi.org/10.1097/00000542-199808000-00016.Full Text Link to Item
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Weiss, L., H. P. Grocott, R. A. Rosania, A. Friedman, M. F. Newman, and D. S. Warner. “Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping.” J Cardiothorac Vasc Anesth 12, no. 4 (August 1998): 473–79. https://doi.org/10.1016/s1053-0770(98)90206-3.Full Text Link to Item
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Sarraf-Yazdi, S., H. Sheng, Y. Miura, C. McFarlane, F. Dexter, R. Pearlstein, and D. S. Warner. “Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat.” Anesth Analg 87, no. 1 (July 1998): 72–78. https://doi.org/10.1097/00000539-199807000-00016.Full Text Link to Item
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Bart, R. D., S. Takaoka, R. D. Pearlstein, F. Dexter, and D. S. Warner. “Interactions between hypothermia and the latency to ischemic depolarization: implications for neuroprotection.” Anesthesiology 88, no. 5 (May 1998): 1266–73. https://doi.org/10.1097/00000542-199805000-00018.Full Text Link to Item
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Klein, S. M., R. A. Greengrass, C. Weltz, and D. S. Warner. “Paravertebral somatic nerve block for outpatient inguinal herniorrhaphy: an expanded case report of 22 patients.” Reg Anesth Pain Med 23, no. 3 (May 1998): 306–10. https://doi.org/10.1016/s1098-7339(98)90059-1.Full Text Link to Item
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Pearlstein, R. D., J. P. Beirne, G. W. Massey, and D. S. Warner. “Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration.” J Neurochem 70, no. 5 (May 1998): 2012–19. https://doi.org/10.1046/j.1471-4159.1998.70052012.x.Full Text Link to Item
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Lockhart, E. M., J. D. Reynolds, J. N. Reynolds, R. D. Pearlstein, D. S. Warner, and D. H. Penning. “Does progesterone protect the fetal brain?” Anesthesiology, April 1, 1998, U15–U15.Link to Item
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Sheng, H., D. T. Laskowitz, E. Bennett, D. E. Schmechel, R. D. Bart, A. M. Saunders, R. D. Pearlstein, A. D. Roses, and D. S. Warner. “Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.” J Cereb Blood Flow Metab 18, no. 4 (April 1998): 361–66. https://doi.org/10.1097/00004647-199804000-00003.Full Text Link to Item
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Class, P. S. A., B. D. Jamerson, M. Colopy, L. A. Fleisher, M. F. Roizen, K. Tuman, R. Twersky, and D. S. Warner. “Is there a difference in adverse events during general anesthesia based on gender, age, or ethnic group.” Anesthesia and Analgesia 86, no. 2S (February 1, 1998): U115–U115.Link to Item
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Fanzca, J. M. F., J. Guy, T. J. Gan, C. O. Borel, and D. S. Warner. “Ondansetron vs placebo: Double-blind, randomized comparison for infratentorial craniotomy.” Anesthesia and Analgesia 86, no. 2S (February 1, 1998): U212–U212.Link to Item
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Miura, Y., H. Grocott, R. Bart, R. Pearlstein, F. Dexter, and D. S. Warner. “Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat.” Anesthesia and Analgesia 86, no. 2S (February 1, 1998): U218–U218.Link to Item
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Warner, D. S., B. D. Jamerson, M. Colopy, L. A. Fleisher, P. S. A. Glass, M. F. Roizen, K. Tuman, and R. Twersky. “Adverse events during general anesthesia with remifentanil: A phase IV comparison trial.” Anesthesia and Analgesia 86, no. 2S (February 1, 1998): U126–U126.Link to Item
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Bart, R., H. Sheng, T. Oury, J. Crapo, R. Pearlstein, and D. Warner. “Modulation of cerebral blood flow is not the mechanism of neuroprotection in transgenic mice over expressing human extracellular superoxide dismutase (EC-SOD).” Critical Care Medicine 26, no. 1 SUPPL. (January 1, 1998). https://doi.org/10.1097/00003246-199801001-00045.Full Text
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Beirne, J. P., R. D. Pearlstein, G. W. Massey, and D. S. Warner. “Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate.” Neurochem Res 23, no. 1 (January 1998): 17–23. https://doi.org/10.1023/a:1022489017731.Full Text Link to Item
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Klein, S. M., R. A. Greengrass, and D. S. Warner. “Paravertebral somatic nerve block for outpatient inguinal herniorraphy.” Regional Anesthesia and Pain Medicine 23, no. 3 SUPPL. (January 1, 1998): 54. https://doi.org/10.1097/00115550-199823031-00054.Full Text
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Morimoto, Y., B. Wu, R. D. Bart, R. D. Pearlstein, and D. S. Warner. “Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat.” Brain Res 779, no. 1–2 (January 1, 1998): 170–76. https://doi.org/10.1016/s0006-8993(97)01113-x.Full Text Link to Item
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Rizzi, R. R. “No difference between remifentanil and fentanyl in patients undergoing craniotomy.” Anesthesiology 88, no. 1 (January 1998): 271–72. https://doi.org/10.1097/00000542-199801000-00038.Full Text Link to Item
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Warner, D. S. “Clinical relevance of animal models for cerebral ischaemia.” European Journal of Anaesthesiology, Supplement 15, no. SUPPL. 17 (January 1, 1998): 12–14. https://doi.org/10.1097/00003643-199801001-00010.Full Text
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Klein, S. M., F. D’Ercole, R. A. Greengrass, and D. S. Warner. “Enoxaparin associated with psoas hematoma and lumbar plexopathy after lumbar plexus block.” Anesthesiology 87, no. 6 (December 1997): 1576–79. https://doi.org/10.1097/00000542-199712000-00040.Full Text Link to Item
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Pittman, J. E., H. Sheng, R. Pearlstein, A. Brinkhous, F. Dexter, and D. S. Warner. “Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat.” Anesthesiology 87, no. 5 (November 1997): 1139–44. https://doi.org/10.1097/00000542-199711000-00018.Full Text Link to Item
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Fabling, J. M., T. J. Gan, J. Guy, C. O. Borel, H. E. el-Moalem, and D. S. Warner. “Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy.” J Neurosurg Anesthesiol 9, no. 4 (October 1997): 308–12.Link to Item
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Morimoto, Y., R. D. Bart, R. D. Pearlstein, F. Dexter, and D. S. Warner. “High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat.” J Neurosurg Anesthesiol 9, no. 4 (October 1997): 316–23. https://doi.org/10.1097/00008506-199710000-00005.Full Text Link to Item
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Grocott, H. P., N. A. Bart, Y. Muira, H. Sheng, N. A. Pearlstein, and D. S. Warner. “A680 NEUROPROTECTION FROM RSR 13 IN A RAT MODEL OF INCOMPLETE FOREBRAIN ISCHEMIA.” Anesthesiology 87, no. Supplement (September 1997): 680A-680A. https://doi.org/10.1097/00000542-199709001-00680.Full Text
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Klein, S. M., R. A. Greengrass, N. Knudsen, G. Leight, and D. S. Warner. “Regional anesthesia for thyroidectomy in two patients with amiodarone-induced hyperthyroidism.” Anesth Analg 85, no. 1 (July 1997): 222–24. https://doi.org/10.1097/00000539-199707000-00041.Full Text Link to Item
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Laskowitz, D. T., H. Sheng, R. D. Bart, K. A. Joyner, A. D. Roses, and D. S. Warner. “Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia.” J Cereb Blood Flow Metab 17, no. 7 (July 1997): 753–58. https://doi.org/10.1097/00004647-199707000-00005.Full Text Link to Item
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Baker, K. Z., N. Ostapkovich, M. B. Sisti, D. S. Warner, and W. L. Young. “Intact cerebral blood flow reactivity during remifentanil/nitrous oxide anesthesia.” J Neurosurg Anesthesiol 9, no. 2 (April 1997): 134–40. https://doi.org/10.1097/00008506-199704000-00005.Full Text Link to Item
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Takaoka, S., R. D. Bart, R. D. Pearlstein, and D. S. Warner. “Glycine antagonism does not block ischemic spontaneous depolarization in the rat.” Neuroreport 8, no. 5 (March 24, 1997): 1139–42. https://doi.org/10.1097/00001756-199703240-00016.Full Text Link to Item
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Guy, J., B. J. Hindman, K. Z. Baker, C. O. Borel, M. Maktabi, N. Ostapkovich, J. Kirchner, et al. “Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions.” Anesthesiology 86, no. 3 (March 1997): 514–24. https://doi.org/10.1097/00000542-199703000-00002.Full Text Link to Item
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Takaoka, S., R. D. Bart, R. Pearlstein, A. Brinkhous, and D. S. Warner. “Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.” J Cereb Blood Flow Metab 17, no. 2 (February 1997): 161–67. https://doi.org/10.1097/00004647-199702000-00005.Full Text Link to Item
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Kim, Y. J., C. McFarlane, D. S. Warner, M. T. Baker, W. W. Choi, and F. Dexter. “The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat.” Anesth Analg 83, no. 6 (December 1996): 1223–28. https://doi.org/10.1097/00000539-199612000-00016.Full Text Link to Item
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Takaoka, S., R. D. Pearlstein, and D. S. Warner. “Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat.” Neurosci Lett 218, no. 1 (October 25, 1996): 25–28. https://doi.org/10.1016/0304-3940(96)13112-8.Full Text Link to Item
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Takaoka, S., R. D. Bart, R. Pearlstein, D. S. Warner, and A. D. Brinkhous. “Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.” Anesthesiology 85, no. 3A (September 1, 1996): A1197–A1197.Link to Item
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Morimoto, Y., D. S. Warner, and R. D. Pearlstein. “Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats.” Stroke 27, no. 8 (August 1996): 1405–9. https://doi.org/10.1161/01.str.27.8.1405.Full Text Link to Item
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Warner, D. S., B. J. Hindman, M. M. Todd, P. D. Sawin, J. Kirchner, C. L. Roland, and B. D. Jamerson. “Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy.” Anesth Analg 83, no. 2 (August 1996): 348–53. https://doi.org/10.1097/00000539-199608000-00025.Full Text Link to Item
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Warner, D. S., S. Takaoka, B. Wu, P. S. Ludwig, R. D. Pearlstein, A. D. Brinkhous, and F. Dexter. “Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia.” Anesthesiology 84, no. 6 (June 1996): 1475–84. https://doi.org/10.1097/00000542-199606000-00024.Full Text Link to Item
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McGrath, B. J., J. Guy, C. O. Borel, A. H. Friedman, and D. S. Warner. “Perioperative management of aneurysmal subarachnoid hemorrhage: Part 2. Postoperative management.” Anesth Analg 81, no. 6 (December 1995): 1295–1302. https://doi.org/10.1097/00000539-199512000-00031.Full Text Link to Item
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Guy, J., B. J. McGrath, C. O. Borel, A. H. Friedman, and D. S. Warner. “Perioperative management of aneurysmal subarachnoid hemorrhage: Part 1. Operative management.” Anesth Analg 81, no. 5 (November 1995): 1060–72. https://doi.org/10.1097/00000539-199511000-00028.Full Text Link to Item
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TAKAOKA, S., R. PEARLSTEIN, and D. S. WARNER. “HYPOTHERMIA REDUCES THE PROPENSITY OF CORTICAL TISSUE TO PROPAGATE DC DEPOLARIZATIONS IN THE RAT.” Anesthesiology 83, no. 3A (September 1, 1995): A710–A710.Link to Item
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McFarlane, C., D. S. Warner, and F. Dexter. “Interactions between NMDA and AMPA glutamate receptor antagonists during halothane anesthesia in the rat.” Neuropharmacology 34, no. 6 (June 1995): 659–63. https://doi.org/10.1016/0028-3908(95)00029-6.Full Text Link to Item
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Nakashima, K., M. M. Todd, and D. S. Warner. “The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypothermia, pentobarbital, and isoflurane.” Anesthesiology 82, no. 5 (May 1995): 1199–1208. https://doi.org/10.1097/00000542-199505000-00015.Full Text Link to Item
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Warner, D. S., P. S. Ludwig, R. Pearlstein, and A. D. Brinkhous. “Halothane reduces focal ischemic injury in the rat when brain temperature is controlled.” Anesthesiology 82, no. 5 (May 1995): 1237–45. https://doi.org/10.1097/00000542-199505000-00019.Full Text Link to Item
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McFarlane, C., D. S. Warner, A. Nader, and F. Dexter. “Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat.” Anesthesiology 82, no. 4 (April 1995): 963–68. https://doi.org/10.1097/00000542-199504000-00020.Full Text Link to Item
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Reasoner, D. K., D. S. Warner, M. M. Todd, S. W. Hunt, and J. Kirchner. “A comparison of anesthetic techniques for awake intubation in neurosurgical patients.” J Neurosurg Anesthesiol 7, no. 2 (April 1995): 94–99. https://doi.org/10.1097/00008506-199504000-00004.Full Text Link to Item
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Warner, D. S., M. M. Todd, F. Dexter, P. Ludwig, and A. M. McAllister. “Temporal thresholds for hyperglycemia-augmented ischemic brain damage in rats.” Stroke 26, no. 4 (April 1995): 655–60. https://doi.org/10.1161/01.str.26.4.655.Full Text Link to Item
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Warner, D. S., H. Martin, P. Ludwig, A. McAllister, J. F. Keana, and E. Weber. “In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists.” J Cereb Blood Flow Metab 15, no. 2 (March 1995): 188–96. https://doi.org/10.1038/jcbfm.1995.24.Full Text Link to Item
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Smith, D. S., and D. S. Warner. “Journal Club.” Journal of Neurosurgical Anesthesiology 7, no. 1 (January 1, 1995): 67.
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Warner, D. S. “Mild hypothermia as a clinical strategy for neuroprotection.” Current Opinion in Anaesthesiology 8, no. 5 (January 1, 1995): 396–400. https://doi.org/10.1097/00001503-199510000-00006.Full Text
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Warner, D. S., P. S. Ludwig, R. Pearlstein, A. D. Brinkhous, and M. M. Todd. “Halothane reduces focal ischemic injury in the rat when brain temperature is controlled.” Anesthesiology 82, no. 5 (January 1, 1995).
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McFarlane, C., D. S. Warner, F. Dexter, and P. A. Ludwig. “Minimum alveolar concentration for halothane in the rat is resistant to effects of forebrain ischemia and reperfusion.” Anesthesiology 81, no. 5 (November 1994): 1206–11. https://doi.org/10.1097/00000542-199411000-00014.Full Text Link to Item
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Todd, M. M., B. Wu, M. Maktabi, B. J. Hindman, and D. S. Warner. “Cerebral blood flow and oxygen delivery during hypoxemia and hemodilution: role of arterial oxygen content.” Am J Physiol 267, no. 5 Pt 2 (November 1994): H2025–31. https://doi.org/10.1152/ajpheart.1994.267.5.H2025.Full Text Link to Item
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Martin, H., D. S. Warner, and M. M. Todd. “Effects of glycine receptor antagonism on spreading depression in the rat.” Neurosci Lett 180, no. 2 (October 24, 1994): 285–89. https://doi.org/10.1016/0304-3940(94)90540-1.Full Text Link to Item
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McFarlane, C., D. S. Warner, F. Dexter, and M. M. Todd. “Glutamatergic antagonism: effects on lidocaine-induced seizures in the rat.” Anesth Analg 79, no. 4 (October 1994): 701–5. https://doi.org/10.1213/00000539-199410000-00014.Full Text Link to Item
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Verhaegen, M., M. M. Todd, and D. S. Warner. “Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow threshold and times to depolarization.” Anesthesiology 81, no. 4 (October 1994): 965–73. https://doi.org/10.1097/00000542-199410000-00024.Full Text Link to Item
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Reasoner, D. K., M. M. Todd, F. L. Scamman, and D. S. Warner. “The incidence of pneumocephalus after supratentorial craniotomy. Observations on the disappearance of intracranial air.” Anesthesiology 80, no. 5 (May 1994): 1008–12. https://doi.org/10.1097/00000542-199405000-00009.Full Text Link to Item
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Todd, M. M., B. Wu, D. S. Warner, and M. Maktabi. “The dose-related effects of nitric oxide synthase inhibition on cerebral blood flow during isoflurane and pentobarbital anesthesia.” Anesthesiology 80, no. 5 (May 1994): 1128–36. https://doi.org/10.1097/00000542-199405000-00022.Full Text Link to Item
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Todd, M. M., B. Wu, and D. S. Warner. “The hemispheric cerebrovascular response to hemodilution is attenuated by a focal cryogenic brain injury.” J Neurotrauma 11, no. 2 (April 1994): 149–60. https://doi.org/10.1089/neu.1994.11.149.Full Text Link to Item
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Hansen, T. D., D. S. Warner, V. C. Traynelis, and M. M. Todd. “Plasma osmolality and brain water content in a rat glioma model.” Neurosurgery 34, no. 3 (March 1994): 505–11. https://doi.org/10.1227/00006123-199403000-00017.Full Text Link to Item
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Warner, D. S. “Perioperative neuroprotection.” Current Opinion in Anaesthesiology 7, no. 5 (January 1, 1994): 416–20. https://doi.org/10.1097/00001503-199410000-00006.Full Text
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Warner, D. S. “Neuroanesthesia.” Current Opinion in Anaesthesiology 7, no. 5 (January 1, 1994): 389–90. https://doi.org/10.1097/00001503-199410000-00001.Full Text
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Hartung, J., and J. E. Cottrell. “Negative inferences about rare events require large samples.” Anesthesiology 79, no. 5 (November 1993): 1155–56.Link to Item
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Warner, D. S., C. McFarlane, M. M. Todd, P. Ludwig, and A. M. McAllister. “Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Possible influence on thermoregulation.” Anesthesiology 79, no. 5 (November 1993): 985–92. https://doi.org/10.1097/00000542-199311000-00017.Full Text Link to Item
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Hansen, T. D., D. S. Warner, V. C. Traynelis, R. M. Roach, and M. M. Todd. “Cerebral blood flow in a rat glioma model during halothane anesthesia.” J Neurosurg Anesthesiol 5, no. 3 (July 1993): 187–93. https://doi.org/10.1097/00008506-199307000-00009.Full Text Link to Item
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Todd, M. M., J. B. Weeks, and D. S. Warner. “A focal cryogenic brain lesion does not reduce the minimum alveolar concentration for halothane in rats.” Anesthesiology 79, no. 1 (July 1993): 139–43. https://doi.org/10.1097/00000542-199307000-00020.Full Text Link to Item
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Todd, M. M., D. S. Warner, M. D. Sokoll, M. A. Maktabi, B. J. Hindman, F. L. Scamman, and J. Kirschner. “A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.” Anesthesiology 78, no. 6 (June 1993): 1005–20. https://doi.org/10.1097/00000542-199306000-00002.Full Text Link to Item
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Todd, M. M., J. B. Weeks, and D. S. Warner. “The influence of intravascular volume expansion on cerebral blood flow and blood volume in normal rats.” Anesthesiology 78, no. 5 (May 1993): 945–53. https://doi.org/10.1097/00000542-199305000-00020.Full Text Link to Item
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Todd, M. M., J. B. Weeks, and D. S. Warner. “Microwave fixation for the determination of cerebral blood volume in rats.” J Cereb Blood Flow Metab 13, no. 2 (March 1993): 328–36. https://doi.org/10.1038/jcbfm.1993.41.Full Text Link to Item
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Todd, M. M., and D. S. Warner. “On the importance of inaccurate bibliographic citations.” Anesthesiology 78, no. 3 (March 1993): 615–16. https://doi.org/10.1097/00000542-199303000-00043.Full Text Link to Item
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Verhaegen, M. J., M. M. Todd, B. J. Hindman, and D. S. Warner. “Cerebral autoregulation during moderate hypothermia in rats.” Stroke 24, no. 3 (March 1993): 407–14. https://doi.org/10.1161/01.str.24.3.407.Full Text Link to Item
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Buchan, A. M., D. Xue, Z. G. Huang, K. H. Smith, H. Lesiuk, and D. S. Warner. “Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.” Journal of Neurosurgical Anesthesiology 4, no. 2 (December 1, 1992): 145–46.
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Knudsen, L., G. E. Cold, H. O. Holgard, U. T. Johansen, S. Jensen, and D. S. Warner. “Effects of flumanzenil on cerebral blood flow and oxygen consumption after midazolam anaesthesia for craniotomy.” Journal of Neurosurgical Anesthesiology 4, no. 2 (December 1, 1992): 146–47.
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McFarlane, C., D. S. Warner, M. M. Todd, and L. Nordholm. “AMPA receptor competitive antagonism reduces halothane MAC in rats.” Anesthesiology 77, no. 6 (December 1992): 1165–70. https://doi.org/10.1097/00000542-199212000-00018.Full Text Link to Item
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Mutch, W. A. C., K. R. A. Ringaert, F. J. Ewert, and D. S. Warner. “Continuous opioid infusions for neurosurgical procedures: A double-blind comparison of alfentanil and fentanyl.” Journal of Neurosurgical Anesthesiology 4, no. 2 (December 1, 1992): 148.
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Spiegel, D. A., F. Dexter, D. S. Warner, M. T. Baker, and M. M. Todd. “Central nervous system toxicity of local anesthetic mixtures in the rat.” Anesth Analg 75, no. 6 (December 1992): 922–28. https://doi.org/10.1213/00000539-199212000-00009.Full Text Link to Item
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Warner, D. S., T. X. Gionet, M. M. Todd, and A. M. McAllister. “Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats.” Stroke 23, no. 12 (December 1992): 1775–80. https://doi.org/10.1161/01.str.23.12.1775.Full Text Link to Item
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Gionet, T. X., D. S. Warner, M. Verhaegen, J. D. Thomas, and M. M. Todd. “Effects of intra-ischemic blood pressure on outcome from 2-vessel occlusion forebrain ischemia in the rat.” Brain Res 586, no. 2 (July 24, 1992): 188–94. https://doi.org/10.1016/0006-8993(92)91626-p.Full Text Link to Item
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Todd, M. M., J. B. Weeks, and D. S. Warner. “Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats.” Am J Physiol 263, no. 1 Pt 2 (July 1992): H75–82. https://doi.org/10.1152/ajpheart.1992.263.1.H75.Full Text Link to Item
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Verhaegen, M., M. M. Todd, and D. S. Warner. “The influence of different concentrations of volatile anesthetics on the threshold for cortical spreading depression in rats.” Brain Res 581, no. 1 (May 22, 1992): 153–55. https://doi.org/10.1016/0006-8993(92)90355-d.Full Text Link to Item
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Ridenour, T. R., D. S. Warner, M. M. Todd, and A. C. McAllister. “Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats.” Stroke 23, no. 5 (May 1992): 733–38. https://doi.org/10.1161/01.str.23.5.733.Full Text Link to Item
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Ridenour, T. R., D. S. Warner, M. M. Todd, and T. X. Gionet. “Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat.” Anesthesiology 76, no. 5 (May 1992): 807–12. https://doi.org/10.1097/00000542-199205000-00020.Full Text Link to Item
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Verhaegen, M. J., M. M. Todd, and D. S. Warner. “A comparison of cerebral ischemic flow thresholds during halothane/N2O and isoflurane/N2O anesthesia in rats.” Anesthesiology 76, no. 5 (May 1992): 743–54. https://doi.org/10.1097/00000542-199205000-00013.Full Text Link to Item
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Jensen, N. F., M. M. Todd, D. J. Kramer, P. A. Leonard, and D. S. Warner. “A comparison of the vasodilating effects of halothane and isoflurane on the isolated rabbit basilar artery with and without intact endothelium.” Anesthesiology 76, no. 4 (April 1992): 624–34. https://doi.org/10.1097/00000542-199204000-00021.Full Text Link to Item
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Ramani, R., M. M. Todd, and D. S. Warner. “A dose-response study of the influence of propofol on cerebral blood flow, metabolism and the electroencephalogram in the rabbit.” J Neurosurg Anesthesiol 4, no. 2 (April 1992): 110–19. https://doi.org/10.1097/00008506-199204000-00006.Full Text Link to Item
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Verhaegen, M. J., M. M. Todd, D. S. Warner, B. James, and J. B. Weeks. “The role of electrode size on the incidence of spreading depression and on cortical cerebral blood flow as measured by H2 clearance.” J Cereb Blood Flow Metab 12, no. 2 (March 1992): 230–37. https://doi.org/10.1038/jcbfm.1992.33.Full Text Link to Item
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Todd, M. M., and D. S. Warner. “A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia.” Anesthesiology 76, no. 2 (February 1992): 161–64.Link to Item
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Bucklin, B. A., D. S. Warner, W. W. Choi, M. M. Todd, and D. H. Chestnut. “Pregnancy does not alter the threshold for lidocaine-induced seizures in the rat.” Anesth Analg 74, no. 1 (January 1992): 57–61. https://doi.org/10.1213/00000539-199201000-00010.Full Text Link to Item
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Dutka, A. J., R. Mink, J. McDermott, J. B. Clark, J. M. Hallenbeck, and D. S. Warner. “Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolism.” Stroke 23, no. 10 (1992): 1515–21.
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Smith, D. S., and D. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 4, no. 1 (January 1, 1992): 53–58. https://doi.org/10.1097/00008506-199201000-00011.Full Text
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Smith, D. S., and D. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 4, no. 2 (January 1, 1992): 145–51. https://doi.org/10.1097/00008506-199204000-00011.Full Text
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Smith, D. S., and D. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 4, no. 3 (January 1, 1992): 203–9. https://doi.org/10.1097/00008506-199207000-00010.Full Text
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Ridenour, T. R., D. S. Warner, M. M. Todd, and M. T. Baker. “Effects of ketamine on outcome from temporary middle cerebral artery occlusion in the spontaneously hypertensive rat.” Brain Res 565, no. 1 (November 22, 1991): 116–22. https://doi.org/10.1016/0006-8993(91)91742-j.Full Text Link to Item
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Warner, D. S., J. G. Zhou, R. Ramani, and M. M. Todd. “Reversible focal ischemia in the rat: effects of halothane, isoflurane, and methohexital anesthesia.” J Cereb Blood Flow Metab 11, no. 5 (September 1991): 794–802. https://doi.org/10.1038/jcbfm.1991.137.Full Text Link to Item
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Gionet, T. X., J. D. Thomas, D. S. Warner, C. R. Goodlett, E. A. Wasserman, and J. R. West. “Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats.” Stroke 22, no. 8 (August 1991): 1040–47. https://doi.org/10.1161/01.str.22.8.1040.Full Text Link to Item
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Kinkor, R. D., and D. S. Warner. “Unexpected myocardial complications after controlled hypotension.” J Neurosurg Anesthesiol 3, no. 2 (June 1991): 136–41. https://doi.org/10.1097/00008506-199106000-00009.Full Text Link to Item
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Ramani, R., M. M. Todd, and D. S. Warner. “The influence of a cryogenic brain injury on the cerebrovascular response to isoflurane in the rabbit.” J Cereb Blood Flow Metab 11, no. 3 (May 1991): 388–97. https://doi.org/10.1038/jcbfm.1991.79.Full Text Link to Item
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Todd, M. M., B. J. Hindman, and D. S. Warner. “Barbiturate protection and cardiac surgery: a different result.” Anesthesiology 74, no. 3 (March 1991): 402–5. https://doi.org/10.1097/00000542-199103000-00002.Full Text Link to Item
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Choi, W. W., D. S. Warner, D. J. Monahan, and M. M. Todd. “Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat.” Am J Obstet Gynecol 164, no. 2 (February 1991): 693–97. https://doi.org/10.1016/s0002-9378(11)80048-7.Full Text Link to Item
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Hansen, T. D., D. S. Warner, M. M. Todd, M. T. Baker, and N. F. Jensen. “The influence of inhalational anesthetics on in vivo and in vitro benzodiazepine receptor binding in the rat cerebral cortex.” Anesthesiology 74, no. 1 (January 1991): 97–104. https://doi.org/10.1097/00000542-199101000-00016.Full Text Link to Item
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Smith, D. S., and D. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 3, no. 4 (January 1, 1991): 308–10. https://doi.org/10.1097/00008506-199112000-00012.Full Text
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Warner, D. S., D. K. Reasoner, M. M. Todd, and A. McAllister. “Secondary hypotensive insults in a rat forebrain ischemia model.” Brain Res 536, no. 1–2 (December 17, 1990): 176–82. https://doi.org/10.1016/0006-8993(90)90023-5.Full Text Link to Item
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Warner, D. S. “Isoflurane: more than an anesthetic?” J Neurosurg Anesthesiol 2, no. 4 (December 1990): 319–21.Link to Item
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From, R. P., D. S. Warner, M. M. Todd, and M. D. Sokoll. “Anesthesia for craniotomy: a double-blind comparison of alfentanil, fentanyl, and sufentanil.” Anesthesiology 73, no. 5 (November 1990): 896–904.Link to Item
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Warner, D. S., J. G. Zhou, R. Ramani, M. M. Todd, and A. McAllister. “Nitrous oxide does not alter infarct volume in rats undergoing reversible middle cerebral artery occlusion.” Anesthesiology 73, no. 4 (October 1990): 686–93. https://doi.org/10.1097/00000542-199010000-00014.Full Text Link to Item
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Weeks, J. B., M. M. Todd, D. S. Warner, and J. Katz. “The influence of halothane, isoflurane, and pentobarbital on cerebral plasma volume in hypocapnic and normocapnic rats.” Anesthesiology 73, no. 3 (September 1990): 461–66. https://doi.org/10.1097/00000542-199009000-00015.Full Text Link to Item
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Reasoner, D. K., D. S. Warner, M. M. Todd, and A. McAllister. “Effects of nitrous oxide on cerebral metabolic rate in rats anaesthetized with isoflurane.” Br J Anaesth 65, no. 2 (August 1990): 210–15. https://doi.org/10.1093/bja/65.2.210.Full Text Link to Item
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Warner, D. S., Z. Zhou, R. Ramani, M. M. Todd, and M. M. McAllister. “Nitrous oxide does not alter infarct volume in rats undergoing reversible middle cerebral artery (MCA) occlusion.” Journal of Neurosurgical Anesthesiology 2, no. 1 (May 9, 1990). https://doi.org/10.1097/00008506-199003000-00023.Full Text
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Warner, D. “Journal club.” Journal of Neurosurgical Anesthesiology 2, no. 4 (January 1, 1990): 308–13. https://doi.org/10.1097/00008506-199012000-00010.Full Text
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Warner, D. S. “Magnesium and the injured brain.” J Neurosurg Anesthesiol 1, no. 4 (December 1989): 360–63. https://doi.org/10.1097/00008506-198912000-00012.Full Text Link to Item
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Kofke, W. A., R. S. Young, P. Davis, S. K. Woelfel, L. Gray, D. Johnson, A. Gelb, R. Meeke, D. S. Warner, and K. S. Pearson. “Isoflurane for refractory status epilepticus: a clinical series.” Anesthesiology 71, no. 5 (November 1989): 653–59. https://doi.org/10.1097/00000542-198911000-00005.Full Text Link to Item
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Kaieda, R., M. M. Todd, J. B. Weeks, and D. S. Warner. “A comparison of the effects of halothane, isoflurane, and pentobarbital anesthesia on intracranial pressure and cerebral edema formation following brain injury in rabbits.” Anesthesiology 71, no. 4 (October 1989): 571–79. https://doi.org/10.1097/00000542-198910000-00016.Full Text Link to Item
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Kaieda, R., M. M. Todd, and D. S. Warner. “Prolonged reduction in colloid oncotic pressure does not increase brain edema following cryogenic injury in rabbits.” Anesthesiology 71, no. 4 (October 1989): 554–60. https://doi.org/10.1097/00000542-198910000-00013.Full Text Link to Item
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Hansen, T. D., D. S. Warner, M. M. Todd, and L. J. Vust. “Effects of nitrous oxide and volatile anaesthetics on cerebral blood flow.” Br J Anaesth 63, no. 3 (September 1989): 290–95. https://doi.org/10.1093/bja/63.3.290.Full Text Link to Item
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Warner, D. S. “Volatile anesthetics and the ischemic brain.” J Neurosurg Anesthesiol 1, no. 3 (September 1989): 290–94. https://doi.org/10.1097/00008506-198909000-00015.Full Text Link to Item
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Warner, D. S., T. D. Hansen, L. Vust, and M. M. Todd. “Distribution of cerebral blood flow during deep isoflurane vs. pentobarbital anesthesia in rats with middle cerebral artery occlusion.” J Neurosurg Anesthesiol 1, no. 3 (September 1989): 219–26. https://doi.org/10.1097/00008506-198909000-00003.Full Text Link to Item
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Westlund, U. J., K. L. Fridrich, D. S. Warner, and M. D. Sokoll. “An unusual anesthetic course in a patient susceptible to malignant hyperthermia.” J Oral Maxillofac Surg 47, no. 8 (August 1989): 860–64. https://doi.org/10.1016/s0278-2391(89)80048-5.Full Text Link to Item
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Hansen, T. D., D. S. Warner, M. M. Todd, and L. J. Vust. “The role of cerebral metabolism in determining the local cerebral blood flow effects of volatile anesthetics: evidence for persistent flow-metabolism coupling.” J Cereb Blood Flow Metab 9, no. 3 (June 1989): 323–28. https://doi.org/10.1038/jcbfm.1989.50.Full Text Link to Item
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Zhou, J. G., M. M. Todd, D. S. Warner, and C. M. Loftus. “EEG changes during carotid occlusion and hypotension in the rat: the effects of nitrous oxide.” J Neurosurg Anesthesiol 1, no. 2 (June 1989): 103–9. https://doi.org/10.1097/00008506-198906000-00004.Full Text Link to Item
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Kaieda, R., M. M. Todd, L. N. Cook, and D. S. Warner. “Acute effects of changing plasma osmolality and colloid oncotic pressure on the formation of brain edema after cryogenic injury.” Neurosurgery 24, no. 5 (May 1989): 671–78. https://doi.org/10.1227/00006123-198905000-00003.Full Text Link to Item
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Blair, J. L., D. S. Warner, and M. M. Todd. “Effects of elevated plasma magnesium versus calcium on cerebral ischemic injury in rats.” Stroke 20, no. 4 (April 1989): 507–12. https://doi.org/10.1161/01.str.20.4.507.Full Text Link to Item
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Warner, D. S., M. D. Sokoll, M. Maktabi, J. C. Godersky, and H. P. Adams. “Nicardipine HCl: clinical experience in patients undergoing anaesthesia for intracranial aneurysm clipping.” Can J Anaesth 36, no. 2 (March 1989): 219–23. https://doi.org/10.1007/BF03011449.Full Text Link to Item
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Kaieda, R., M. M. Todd, and D. S. Warner. “The effects of anesthetics and PaCO2 on the cerebrovascular, metabolic, and electroencephalographic responses to nitrous oxide in the rabbit.” Anesth Analg 68, no. 2 (February 1989): 135–43. https://doi.org/10.1213/00000539-198902000-00012.Full Text Link to Item
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Smith, D. S., and D. Warner. “Journal club.” Journal of Neurosurgical Anesthesiology 1, no. 4 (January 1, 1989): 387–92. https://doi.org/10.1097/00008506-198912000-00018.Full Text
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Hansen, T. D., D. S. Warner, M. M. Todd, L. J. Vust, and D. C. Trawick. “Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats.” Anesthesiology 69, no. 3 (September 1988): 332–37. https://doi.org/10.1097/00000542-198809000-00008.Full Text Link to Item
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Smith, M. L., H. Kalimo, D. S. Warner, and B. K. Siesjö. “Morphological lesions in the brain preceding the development of postischemic seizures.” Acta Neuropathol 76, no. 3 (1988): 253–64. https://doi.org/10.1007/BF00687772.Full Text Link to Item
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Warner, D. S., J. C. Godersky, and M. L. Smith. “Failure of pre-ischemic lidocaine administration to ameliorate global ischemic brain damage in the rat.” Anesthesiology 68, no. 1 (January 1988): 73–78. https://doi.org/10.1097/00000542-198801000-00012.Full Text Link to Item
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Warner, D. S., and L. A. Boehland. “Effects of iso-osmolal intravenous fluid therapy on post-ischemic brain water content in the rat.” Anesthesiology 68, no. 1 (January 1988): 86–91. https://doi.org/10.1097/00000542-198801000-00014.Full Text Link to Item
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Olson, J. J., D. W. Beck, D. S. Warner, and H. Coester. “The role of new vessels and macrophages in the development and resolution of edema following a cortical freeze lesion in the mouse.” J Neuropathol Exp Neurol 46, no. 6 (November 1987): 682–94. https://doi.org/10.1097/00005072-198711000-00007.Full Text Link to Item
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Olson, J. J., D. W. Beck, and D. S. Warner. “Acute effect of angiographic contrast medium on cortical specific gravity after middle cerebral artery occlusion in rats.” Stroke 18, no. 5 (September 1987): 924–26. https://doi.org/10.1161/01.str.18.5.924.Full Text Link to Item
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Warner, D. S., M. L. Smith, and B. K. Siesjö. “Ischemia in normo- and hyperglycemic rats: effects on brain water and electrolytes.” Stroke 18, no. 2 (March 1987): 464–71. https://doi.org/10.1161/01.str.18.2.464.Full Text Link to Item
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Warner, D. S., D. M. Turner, and N. F. Kassell. “Time-dependent effects of prolonged hypercapnia on cerebrovascular parameters in dogs: acid-base chemistry.” Stroke 18, no. 1 (January 1987): 142–49. https://doi.org/10.1161/01.str.18.1.142.Full Text Link to Item
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Maktabi, M., D. Warner, M. Sokoll, D. Boarini, A. Adolphson, T. Speed, and N. Kassell. “Comparison of nitroprusside, nitroglycerin, and deep isoflurane anesthesia for induced hypotension.” Neurosurgery 19, no. 3 (September 1986): 350–55. https://doi.org/10.1227/00006123-198609000-00003.Full Text Link to Item
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Warner, D. S., J. K. Deshpande, and T. Wieloch. “The effect of isoflurane on neuronal necrosis following near-complete forebrain ischemia in the rat.” Anesthesiology 64, no. 1 (January 1986): 19–23. https://doi.org/10.1097/00000542-198601000-00004.Full Text Link to Item
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Warner, D. S., D. J. Boarini, and N. F. Kassell. “Cerebrovascular adaptation to prolonged halothane anesthesia is not related to cerebrospinal fluid pH.” Anesthesiology 63, no. 3 (September 1985): 243–48. https://doi.org/10.1097/00000542-198509000-00001.Full Text Link to Item
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Warner, D. S., J. K. Deshpande, and T. Wieloch. “Isoflurane titrated to EEG burst suppression does not provide cerebral protection in the rat.” Anesthesiology Review 12, no. 5 (January 1, 1985): 16–17.
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McCook, T. A., D. K. Heaston, D. S. Warner, R. B. Malone, and S. R. Mills. “A 40 degree craniocaudad AP projection for superimposed renal artery branches.” Ajr Am J Roentgenol 135, no. 6 (December 1980): 1300–1301. https://doi.org/10.2214/ajr.135.6.1300.Full Text Link to Item
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Warner, D., and R. H. Daffner. “An aid to remembering cruciate ligament position.” Ajr Am J Roentgenol 135, no. 5 (November 1980): 1103. https://doi.org/10.2214/ajr.135.5.1103.Full Text Link to Item
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Laskowitz, D. T., J. R. Lynch, D. S. Warner, and J. Pineda. “Apolipoprotein E modulates the CNS response to injury.” Journal of Neurochemistry 81 (n.d.): 31–31. https://doi.org/10.1046/j.1471-4159.81.s1.74.x.Full Text
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Other Articles
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Mackensen, G. B., L. K. Ti, B. G. Phillips-Bute, J. P. Mathew, M. F. Newman, H. P. Grocott, and H. P. Neurologic Outcome Research Group (NORG). “Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.” Br J Anaesth, November 2003. https://doi.org/10.1093/bja/aeg234.Full Text Link to Item
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Swaminathan, Madhav, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, and Mark Perioperative Outcomes Research Group. “Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.” Anesth Analg, July 2002. https://doi.org/10.1097/00000539-200207000-00001.Full Text Link to Item
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Grigore, Alina M., Hilary P. Grocott, Joseph P. Mathew, Barbara Phillips-Bute, Timothy O. Stanley, Aimee Butler, Kevin P. Landolfo, et al. “The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.” Anesth Analg, January 2002. https://doi.org/10.1097/00000539-200201000-00002.Full Text Link to Item
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Conference Papers
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Ma, Shuang, Dongmei Chu, Litao Li, Huaxin Sheng, David S. Warner, and Ulrike Hoffmann. “24 HOUR POST-TREATMENT WITH THE NOBLE GAS ARGON PROVIDES ROBUST NEUROPROTECTION AND IMPROVEMENT IN NEUROLOGIC OUTCOME AFTER FOCAL CEREBRAL ISCHEMIA IN RATS.” In Anesthesia and Analgesia, 126:312–312. LIPPINCOTT WILLIAMS & WILKINS, 2018.Link to Item
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Sheng, H., L. Li, B. Yan, H. Sun, and D. S. Warner. “Xenon as a therapy in experimental intracerebral hemorrhage.” In Journal of Cerebral Blood Flow and Metabolism, 37:451–451. SAGE PUBLICATIONS INC, 2017.Link to Item
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Lei, Beilei, Haichen Wang, Seongtae Jeong, Justin T. Hsieh, Mohammed Majeed, Hana Dawson, Huaxin Sheng, David S. Warner, and Michael L. James. “Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.” In Neuroendocrinology, 103:665–77, 2016. https://doi.org/10.1159/000442204.Full Text Link to Item
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Weitner, Tin, Huaxin Sheng, Sumitra Miriyala, David Leu, Artak Tovmasyan, Ivan Kos, Julio S. Reboucas, et al. “Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution.” In Free Radical Biology and Medicine, 53:S118–S118. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.291.Full Text
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Rajic, Zrinka, Artak Tovmasyan, Alice M. Li, Edith B. Gralla, Huaxin Sheng, David S. Warner, Ludmil Benov, Ivan Spasojevic, and Ines Batinic-Haberle. “A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties.” In Free Radical Biology and Medicine, 51:S95–S95. Elsevier BV, 2011. https://doi.org/10.1016/j.freeradbiomed.2011.10.462.Full Text
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Tovmasyan, Artak, Zrinka Rajic, Ivan Spasojevic, Julio Reboucas, Huaxin Sheng, David S. Warner, Alice Li, Edith B. Gralla, Ludmil Benov, and Ines Batinic-Haberle. “Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies.” In Free Radical Biology and Medicine, 49:S201–S201. Elsevier BV, 2010. https://doi.org/10.1016/j.freeradbiomed.2010.10.583.Full Text
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Kos, Ivan, Julio S. Reboucas, Huaxin Sheng, David S. Warner, Ivan Spasojevic, and Ines Batinic-Haberle. “Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator.” In Free Radical Biology and Medicine, 45:S86–87. ELSEVIER SCIENCE INC, 2008.Link to Item
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McAdoo, J. D., D. S. Warner, R. Pearlstein, R. F. Gross, R. N. Goldberg, and D. Laskowitz. “Apolipoprotein E-mimetic peptide reduces brain injury in a neonatal hypoxia-ischemia model.” In Pediatric Research, 55:408A-408A. INT PEDIATRIC RESEARCH FOUNDATION, INC, 2004.Link to Item
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Lynch, J. R., H. C. Wang, W. Tang, M. Vitek, L. Durham, P. Sullivan, D. S. Warner, and D. T. Laskowitz. “An ApoE-based therapeutic improves outcome and reduces Alzheimer's disease pathology after head injury.” In Annals of Neurology, 56:S42–S42. WILEY-LISS, 2004.Link to Item
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Warner, D. S., H. X. Sheng, R. D. Pearlstein, and C. A. Piantadosi. “Ec-SOD overexpression reduces blood-spinal cord barrier permeability and inflammatory cell infiltration, but does not improve outcome from spinal cord compression injury in the mouse.” In Free Radical Biology and Medicine, 37:S165–S165. PERGAMON-ELSEVIER SCIENCE LTD, 2004.Link to Item
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McGirt, M. J., J. R. Lynch, R. D. Pearlstein, D. S. Warner, and D. T. Laskowitz. “Statins improve neurological outcome, attenuate hippocampal neuronal degeneration, and decrease interleukin-6 expression after experimental traumatic brain injury.” In Neurosurgery, 53:481–481. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Leinenweber, S. B., L. Mamo, E. Nozik-Grayck, and D. S. Warner. “Expression of extracellular superoxide dismutase is increased after traumatic brain injury.” In Critical Care Medicine, 31:A13–A13, 2003.Link to Item
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Sheng, H. X., I. Spasojevic, D. S. Warner, and I. Batinic-Haberle. “Mn(III) meso tetrakis(N,N '-diethylimidazolium-2-yl)porphyrin (AEOL-10150) offers protection in mouse model of spinal cord injury.” In Free Radical Biology and Medicine, 35:S154–S154. PERGAMON-ELSEVIER SCIENCE LTD, 2003.Link to Item
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Warner, D. S. “Anesthesia for craniotomy.” In Anesthesia and Analgesia, 94:115–21. LIPPINCOTT WILLIAMS & WILKINS, 2002.Link to Item
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Sheng, H. X., I. Batinic-Haberle, I. Spasojevic, I. Fridovich, and D. S. Warner. “Mn(III) meso-tetrakis(ortho N-ethyl-pyridyl)porphyrin, MnTE-2-PyP (AEOL-10113) offers protection in mouse spinal cord injury model.” In Free Radical Biology and Medicine, 33:S436–S436. PERGAMON-ELSEVIER SCIENCE LTD, 2002.Link to Item
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Warner, D. S. “Mild hypothermic brain protection.” In Neuroanesthesia, edited by J. O. Johnson, R. J. Sperry, and T. H. Stanley, 32:331–43. KLUWER ACADEMIC PUBL, 1997.Link to Item
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Warner, D. S. “Opioids and the neurosurgical patient.” In Neuroanesthesia, edited by J. O. Johnson, R. J. Sperry, and T. H. Stanley, 32:237–43. KLUWER ACADEMIC PUBL, 1997.Link to Item
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Warner, D. S. “Effects of anesthetic agents on ischemic brain.” In Neuroanesthesia, edited by J. O. Johnson, R. J. Sperry, and T. H. Stanley, 32:165–77. KLUWER ACADEMIC PUBL, 1997.Link to Item
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