David William Zaas

Journal article Am J Respir Crit Care Med · September 15, 2010 Featured Publication RATIONALE: Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients. OBJEC ... Full text Link to item Cite

Complex bacterial infections pre- and posttransplant.

Journal article Seminars in respiratory and critical care medicine · April 2010 Featured Publication Infections complications following lung transplantation are associated with significant morbidity and mortality. Management of infections is most challenging in patients with cystic fibrosis (CF), but all lung transplant recipients are at heightened risk f ... Full text Cite

The expanding roles of caveolin proteins in microbial pathogenesis.

Journal article Commun Integr Biol · November 2009 Featured Publication Caveolin proteins have been implicated in a wide range of cellular functions including lipid raft mediated endocytosis and regulation of cell signaling cascades. Recent discoveries have shown that these proteins are involved not only in regulating these ho ... Full text Link to item Cite

Update on medical complications involving the lungs.

Journal article Current opinion in organ transplantation · October 2009 Featured Publication Purpose of reviewLung transplant is now an accepted treatment for end-stage lung disease with improving survival and an increasing number of transplants being performed every year. Recognition of the common medical complications after lung transpl ... Full text Cite

Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.

Journal article J Biol Chem · April 10, 2009 Featured Publication Pseudomonas aeruginosa has the capacity to invade lung epithelial cells by co-opting the intrinsic endocytic properties of lipid rafts, which are rich in cholesterol, sphingolipids, and proteins, such as caveolin-1 and -2. We compared intratracheal Pseudom ... Full text Link to item Cite

Lung transplantation at Duke University.

Journal article Clin Transpl · 2009 Featured Publication Clinical lung transplantation continues to grow worldwide. Advances in donor selection and management have been critical to support the expanded growth of lung transplant as a therapeutic option for patients with advanced lung disease. In recent years, all ... Link to item Cite

Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation.

Journal article Am J Transplant · December 2007 Featured Publication Despite substantial improvements in early survival after lung transplantation, refractory acute rejection (RAR) and bronchiolitis obliterans syndrome (BOS) remain major contributors to transplant-related morbidity and mortality. We have utilized alemtuzuma ... Full text Link to item Cite

Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection.

Journal article Am J Transplant · May 2007 Featured Publication The incidence of atypical mycobacterial infection among solid organ transplant recipients is increasing. While lung transplant recipients in particular are at greater risk of atypical mycobacterial infection than other solid organ transplant recipients, it ... Full text Link to item Cite

Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

Journal article Nat Med · May 2007 Featured Publication The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated u ... Full text Link to item Cite

The role of lipid rafts in the pathogenesis of bacterial infections.

Journal article Biochim Biophys Acta · December 30, 2005 Featured Publication Numerous pathogens have evolved mechanisms of co-opting normal host endocytic machinery as a means of invading host cells. While numerous pathogens have been known to enter cells via traditional clathrin-coated pit endocytosis, a growing number of viral an ... Full text Link to item Cite

Bacterial penetration of the mucosal barrier by targeting lipid rafts.

Journal article J Investig Med · September 2005 Featured Publication Several traditionally extracellular pathogens not known to possess invasive capacity have been shown to invade various mucosal epithelial cells. The mucosal epithelium performs an important barrier function and is not typically amenable to bacterial invasi ... Full text Link to item Cite

Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2.

Journal article J Biol Chem · February 11, 2005 Featured Publication Pseudomonas aeruginosa is a major cause of pneumonia in patients with cystic fibrosis and other immuncompromising conditions. Here we showed that P. aeruginosa invades type I pneumocytes via a lipid raft-mediated mechanism. P. aeruginosa invasion of rat pr ... Full text Link to item Cite

Airway obstruction is common but unsuspected in patients admitted to a general medicine service.

Journal article Chest · January 2004 Featured Publication Study objectivesObstructive lung disease (OLD) is a worldwide health problem with major impact on health and economics, and can be easily diagnosed by spirometry. Recent expert panels have emphasized the underreporting and underrecognition of this ... Full text Cite

Genetics of environmental asthma.

Journal article Seminars in respiratory and critical care medicine · April 2003 Featured Publication The prevalence of asthma continues to increase throughout Western societies and now is estimated to affect nearly 10% of Americans. Asthma is a syndrome that results when a genetically susceptible individual is exposed to specific allergens, which triggers ... Full text Cite

Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions?

Journal article Chest · January 2003 Featured Publication Full text Link to item Cite