Scholars@Duke
David William Zaas

David William Zaas

Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
david.zaas@duke.edu
40 Duke Medicine Circle, DUMC Box 3701, Durham, NC 27710
40 Duke Medicine Circle, DUMC Box 3701, Durham, NC 27710

Scholarly Works - Journal articles

Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia dolosa (genomovar VI).

Journal article Clinical transplantation · May 2018 Cystic fibrosis (CF) with severe lung disease is a well-recognized indication for lung transplantation. Colonization with various organisms in CF patients may impact post-transplant morbidity and mortality. Burkholderia cepacia complex (BCC) is made up of ... Full text Cite

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation.

Journal article Respir Care · January 2016 BACKGROUND: An increasing number of centers are using active rehabilitation and ambulation for critically ill patients on extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation. This investigation assessed the economic impact at a s ... Full text Link to item Cite

Ambulatory extracorporeal membrane oxygenation as a bridge to lung transplantation: walking while waiting.

Journal article Chest · May 2015 The proportion of critically ill patients awaiting lung transplantation has increased since the implementation of the Lung Allocation Score (LAS) in 2005. Critically ill patients comprise a sizable proportion of wait-list mortality and are known to experie ... Full text Link to item Cite

Candidacy for lung transplant and lung allocation.

Journal article Thoracic surgery clinics · January 2015 This article provides a summary of the changes in lung transplantation after implementation of the Lung Allocation Score in 2005. Specific issues that are addressed include impact of diagnosis group, age, critical illness, and geographic disparities in tra ... Full text Cite

Ambulatory ECMO as a bridge to lung transplant in a previously well pediatric patient with ARDS.

Journal article Pediatrics · August 2014 Extracorporeal membrane oxygenation (ECMO) is increasingly implemented in patients with end-stage pulmonary disease as a bridge to lung transplant. Several centers have instituted an approach that involves physical rehabilitation and ambulation for patient ... Full text Link to item Cite

Epidemiology of invasive mold infections in lung transplant recipients.

Journal article Am J Transplant · June 2014 Invasive mold infections (IMIs) are a major source of morbidity and mortality among lung transplant recipients (LTRs), yet information regarding the epidemiology of IMI in this population is limited. From 2001 to 2006, multicenter prospective surveillance ... Full text Link to item Cite

Rationing in urologic oncology: lessons from sipuleucel-T for advanced prostate cancer.

Journal article Urol Oncol · October 2013 OBJECTIVES: As complex novel cancer drugs are developed, supply may transiently fail to meet demand as production capacity established for research purposes is scaled up to meet anticipated clinical volume. There are no clear guidelines for how clinicians ... Full text Link to item Cite

Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation.

Journal article Respir Care · August 2013 BACKGROUND: Patients with end-stage lung disease often progress to critical illness, which dramatically reduces their chance of survival following lung transplantation. Pre-transplant deconditioning has a significant impact on outcomes for all lung transpl ... Full text Link to item Cite

Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.

Journal article Chest · July 2013 BACKGROUND: Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a ... Full text Link to item Cite

An official American Thoracic Society/International Society for Heart and Lung Transplantation/Society of Critical Care Medicine/Association of Organ and Procurement Organizations/United Network of Organ Sharing Statement: ethical and policy considerations in organ donation after circulatory determination of death.

Journal article American journal of respiratory and critical care medicine · July 2013 RationaleDonation after circulatory determination of death (DCDD) has the potential to increase the number of organs available for transplantation. Because consent and management of potential donors must occur before death, DCDD raises unique ethi ... Full text Cite

Functional status after lung transplantation in older adults in the post-allocation score era.

Journal article Am J Transplant · January 2013 This manuscript describes the functional status trajectory of older (age 65 or older) and younger (age 18-64) adults after lung transplantation (LT). After the implementation of the lung allocation score (LAS) in 2005, older adults became the fastest growi ... Full text Link to item Cite

Solid-organ transplantation in older adults: current status and future research.

Journal article Am J Transplant · October 2012 An increasing number of patients older than 65 years are referred for and have access to organ transplantation, and an increasing number of older adults are donating organs. Although short-term outcomes are similar in older versus younger transplant recipi ... Full text Link to item Cite

Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach.

Journal article Crit Care Med · December 2011 OBJECTIVE: Extracorporeal membrane oxygenation as a bridge to lung transplantation has traditionally been associated with substantial morbidity and mortality. A major contributor to these complications may be weakness and overall deconditioning secondary t ... Full text Link to item Cite

Update on infectious complications following lung transplantation.

Journal article Current opinion in pulmonary medicine · May 2011 Purpose of reviewLung transplantation is an important therapeutic treatment for many patients with life-threatening pulmonary diseases; however, long-term survival is still relatively limited compared with other solid organ transplants. Over the l ... Full text Cite

Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients.

Journal article Am J Respir Crit Care Med · September 15, 2010 Featured Publication RATIONALE: Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients. OBJEC ... Full text Link to item Cite

Complex bacterial infections pre- and posttransplant.

Journal article Seminars in respiratory and critical care medicine · April 2010 Featured Publication Infections complications following lung transplantation are associated with significant morbidity and mortality. Management of infections is most challenging in patients with cystic fibrosis (CF), but all lung transplant recipients are at heightened risk f ... Full text Cite

The expanding roles of caveolin proteins in microbial pathogenesis.

Journal article Commun Integr Biol · November 2009 Featured Publication Caveolin proteins have been implicated in a wide range of cellular functions including lipid raft mediated endocytosis and regulation of cell signaling cascades. Recent discoveries have shown that these proteins are involved not only in regulating these ho ... Full text Link to item Cite

Update on medical complications involving the lungs.

Journal article Current opinion in organ transplantation · October 2009 Featured Publication Purpose of reviewLung transplant is now an accepted treatment for end-stage lung disease with improving survival and an increasing number of transplants being performed every year. Recognition of the common medical complications after lung transpl ... Full text Cite

Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa.

Journal article J Biol Chem · April 10, 2009 Featured Publication Pseudomonas aeruginosa has the capacity to invade lung epithelial cells by co-opting the intrinsic endocytic properties of lipid rafts, which are rich in cholesterol, sphingolipids, and proteins, such as caveolin-1 and -2. We compared intratracheal Pseudom ... Full text Link to item Cite

Lung transplantation at Duke University.

Journal article Clin Transpl · 2009 Featured Publication Clinical lung transplantation continues to grow worldwide. Advances in donor selection and management have been critical to support the expanded growth of lung transplant as a therapeutic option for patients with advanced lung disease. In recent years, all ... Link to item Cite

Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation.

Journal article Am J Transplant · December 2007 Featured Publication Despite substantial improvements in early survival after lung transplantation, refractory acute rejection (RAR) and bronchiolitis obliterans syndrome (BOS) remain major contributors to transplant-related morbidity and mortality. We have utilized alemtuzuma ... Full text Link to item Cite

Author reply--an unusual case of cardiac amyloidosis.

Journal article Journal of general internal medicine · September 2007 Full text Cite

An unusual case of cardiac amyloidosis.

Journal article Journal of general internal medicine · July 2007 Cardiac amyloidosis can result from any of the systemic amyloidoses. The disease is often characterized by a restrictive cardiomyopathy although the particular signs and symptoms depend in part on the underlying cause. In addition to managing the symptoms ... Full text Cite

Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection.

Journal article Am J Transplant · May 2007 Featured Publication The incidence of atypical mycobacterial infection among solid organ transplant recipients is increasing. While lung transplant recipients in particular are at greater risk of atypical mycobacterial infection than other solid organ transplant recipients, it ... Full text Link to item Cite

Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

Journal article Nat Med · May 2007 Featured Publication The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated u ... Full text Link to item Cite

The role of lipid rafts in the pathogenesis of bacterial infections.

Journal article Biochim Biophys Acta · December 30, 2005 Featured Publication Numerous pathogens have evolved mechanisms of co-opting normal host endocytic machinery as a means of invading host cells. While numerous pathogens have been known to enter cells via traditional clathrin-coated pit endocytosis, a growing number of viral an ... Full text Link to item Cite

Bacterial penetration of the mucosal barrier by targeting lipid rafts.

Journal article J Investig Med · September 2005 Featured Publication Several traditionally extracellular pathogens not known to possess invasive capacity have been shown to invade various mucosal epithelial cells. The mucosal epithelium performs an important barrier function and is not typically amenable to bacterial invasi ... Full text Link to item Cite

The role of the innate immune system in lung allograft rejection

Journal article Current Opinion in Organ Transplantation · September 1, 2005 Purpose of review: The long-term survival after lung transplantation is limited by high rates of lung allograft rejection. Although innate immunity is central to pulmonary host defense, its role in transplantation biology has been previously unstudied. In ... Full text Cite

Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2.

Journal article J Biol Chem · February 11, 2005 Featured Publication Pseudomonas aeruginosa is a major cause of pneumonia in patients with cystic fibrosis and other immuncompromising conditions. Here we showed that P. aeruginosa invades type I pneumocytes via a lipid raft-mediated mechanism. P. aeruginosa invasion of rat pr ... Full text Link to item Cite

Airway obstruction is common but unsuspected in patients admitted to a general medicine service.

Journal article Chest · January 2004 Featured Publication Study objectivesObstructive lung disease (OLD) is a worldwide health problem with major impact on health and economics, and can be easily diagnosed by spirometry. Recent expert panels have emphasized the underreporting and underrecognition of this ... Full text Cite

Cases from the Osler Medical Service at Johns Hopkins University.

Journal article The American journal of medicine · June 2003 Full text Cite

Genetics of environmental asthma.

Journal article Seminars in respiratory and critical care medicine · April 2003 Featured Publication The prevalence of asthma continues to increase throughout Western societies and now is estimated to affect nearly 10% of Americans. Asthma is a syndrome that results when a genetically susceptible individual is exposed to specific allergens, which triggers ... Full text Cite

Cases from the Osler Medical Service at Johns Hopkins University. Antiglomerular basement membrane disease.

Journal article The American journal of medicine · April 2003 A 47-year-old Taiwanese man with no notable medical history was admitted with low-grade fevers and night sweats that had persisted for 5 to 6 weeks. An extensive investigation at another hospital could not determine the cause of the fevers, but documented ... Full text Cite

Cases from the Osler Medical Service at Johns Hopkins University.

Journal article The American journal of medicine · February 2003 Full text Cite

Mucosa-associated lymphoid tissue disease in the lung: When should it be treated as lymphoma?

Journal article Journal of Bronchology · January 1, 2003 We report a patient with mucosa-associated lymphoid tissue (MALT) disease with gastric, bone marrow, and pulmonary involvement and discuss features of this condition that justify its classification and treatment as a lymphoma. The chest radiographic appear ... Full text Cite

Cases from the Osler Medical Service at Johns Hopkins University. Scedosporium apiospermum mycetoma of the lung.

Journal article The American journal of medicine · December 2002 PRESENTING FEATURES: A 42-year-old man was admitted with a chief complaint of cough and night sweats of 2 months' duration. The cough produced brown sputum but no blood. He also reported drenching sweats every night for the last several weeks before admiss ... Full text Cite

An uncommon mimic of an acute asthma exacerbation.

Journal article Chest · May 2002 Foreign body aspiration in adults has a variety of clinical presentations and often goes unrecognized. We describe the case of a patient who experienced crack cocaine aspiration and presented with symptoms of an acute asthma exacerbation requiring mechanic ... Full text Cite

Decreased levels of CD54 (ICAM-1)-positive lymphocytes in the peripheral blood in untreated patients with active juvenile dermatomyositis.

Journal article Clinical and diagnostic laboratory immunology · July 2000 Significant abnormalities are observed in the peripheral blood of juvenile dermatomyositis (JDM) patients with active disease. In this study, we confirm that there is a significant increase in the relative percentage of B lymphocytes in the peripheral bloo ... Full text Cite

Development of a rapid whole blood flow cytometry procedure for the diagnosis of X-linked hyper-IgM syndrome patients and carriers.

Journal article Clinical immunology and immunopathology · November 1997 The CD40 ligand expressed on activated T cells plays a pivotal role in B cell proliferation and differentiation. Mutations in the CD40 ligand gene, which alter its expression on the surface of activated T cells, are associated with the X-linked form of Hyp ... Full text Cite