Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Louisiana State University 1999
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Surgery, Surgery, Surgical Sciences, Surgery 2012 - 2020
  • Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2006 - 2012
  • Assistant Research Professor in Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2005 - 2006
  • Instructor, Temporary in the Department of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2004 - 2005
• Research
• 

  Selected Grants

  • A Multi-omics and Multi-Species Examination of Combined Environmental Stressors of Space Exploration awarded by National Aeronautics and Space Administration 2021 - 2024
  • Fortilin, CTNNA3, and the Heart awarded by University of Washington 2021 - 2023
  • Right Ventricular Metabolic Dysregulation after Surgery for Heart Failure awarded by  International Anesthesia Research Society 2021 - 2023
  • Duke Resident Physician-Scientist Program- NHLBI awarded by National Institutes of Health 2018 - 2022
  • Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration awarded by National Aeronautics and Space Administration 2016 - 2022
  • Radiation Resistance Conferred by Small Proline Rich Proteins (SPRRs) awarded by National Aeronautics and Space Administration 2021 - 2022
  • Gene Therapy Countermeasure for Detrimental Effects of Space Radiation awarded by Baylor College of Medicine 2019 - 2021
  • Enzyvant Monkey Study awarded by Enzyvant 2019 - 2021
  • Stratification of heart failure patients for cardiac recovery upon cardiac unloading by left Ventricular assist device therapy awarded by Humanitas Mirasole S.p.a 2020 - 2021
  • Awakening Endogenous Retroviruses with the Space Environment awarded by National Aeronautics and Space Administration 2019 - 2021
  • Development of a lightweight, portable, pneumatic drive unit for long-term counterpulsation support awarded by NuPulseCV, Inc. 2019 - 2020
  • Evolving Inside the Box awarded by North Carolina Biotechnology Center 2018 - 2020
  • Heart Cap Implants awarded by North Carolina State University 2019 - 2020
  • Utilization of Two Heartmate III Pumps as a Total Artificial Heart Replacement awarded by St. Jude Medical Inc. 2017 - 2019
  • Expanding the capabilities and the utilization of the Duke Human Heart Repository awarded by North Carolina Biotechnology Center 2017 - 2019
  • Cadaver Implant Studies of PABP awarded by 3R Life Sciences Taiwan Ltd. 2018 - 2019
  • Protection from cardiac ischemic injury through use of KP544 awarded by Krenitsky Pharmaceuticals Inc. 2017 - 2018
  • A Prospective Pilot Study to Examine the Involvement of apoE Gene Variants in Intracranial Hemorrhage in LVAD Patients awarded by HeartWare, Inc 2015 - 2016
  • E3 Ligases and Deubiquitinases in GPCR Down Regulation awarded by National Institutes of Health 2005 - 2016
  • Heart Risk Model awarded by National Aeronautics and Space Administration 2013 - 2016
  • Expanding the Donor Pool for Heart Transplantation awarded by National Institutes of Health 2012 - 2014
  • Proteomic Profiling of Human Heart Tissue Exposed to Microgravity awarded by National Aeronautics and Space Administration 2012 - 2013
  • Peripheral endothelial and muscle cell pathology in cardiovascular disease awarded by National Institutes of Health 2010 - 2013
  • Autologous EPC lining to improve biocompatibility of circulatory assist devices awarded by National Institutes of Health 2009 - 2012
  • PTEN Gene Therapy for Vein Graft Disease awarded by National Institutes of Health 2009 - 2012
  • Myocardial Gene Transfer during Cardiac Surgery in Swine awarded by National Institutes of Health 2003 - 2008
• 

  External Relationships

  • Caripae, LLC
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bishawi, Muath, Franklin H. Lee, Dennis M. Abraham, Carolyn Glass, Stephanie J. Blocker, Daniel J. Cox, Zachary D. Brown, et al. “Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.” Iscience 25, no. 4 (April 15, 2022): 104086. https://doi.org/10.1016/j.isci.2022.104086.
       Full Text  Link to Item
    • Mendiola Pla, Michelle, Amy Evans, Franklin H. Lee, Yuting Chiang, Muath Bishawi, Andrew Vekstein, Lillian Kang, et al. “A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft.” J Vis Exp, no. 180 (February 14, 2022). https://doi.org/10.3791/63114.
       Full Text  Link to Item
    • Vekstein, Andrew M., David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen, Muath Bishawi, Garth W. Devlin, et al. “Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts.” Front Cardiovasc Med 9 (2022): 833335. https://doi.org/10.3389/fcvm.2022.833335.
       Full Text  Link to Item
    • Truby, Lauren K., Lydia Coulter Kwee, Richa Agarwal, Elizabeth Grass, Adam D. DeVore, Chetan B. Patel, Dongfeng Chen, et al. “Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.” J Heart Lung Transplant 40, no. 12 (December 2021): 1589–98. https://doi.org/10.1016/j.healun.2021.07.024.
       Full Text  Link to Item
    • Chunhacha, Preedakorn, Decha Pinkaew, Patuma Sinthujaroen, Dawn E. Bowles, and Ken Fujise. “Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects the heart against heart failure.” Cell Death Discov 7, no. 1 (October 23, 2021): 310. https://doi.org/10.1038/s41420-021-00692-w.
       Full Text  Link to Item
    • Bishawi, Muath, Dawn Bowles, Michelle Mendiola Pla, Faye Oakes, Yuting Chiang, Jacob Schroder, Carmelo Milano, and Carolyn Glass. “PD-1 and PD-L1 expression in cardiac transplantation.” Cardiovasc Pathol 54 (September 2021): 107331. https://doi.org/10.1016/j.carpath.2021.107331.
       Full Text  Link to Item
    • Venkatakrishnan, Aarushi, Zoie E. Holzknecht, Rob Holzknecht, Dawn E. Bowles, Sanet H. Kotzé, Jennifer L. Modliszewski, and William Parker. “Evolution of bacteria in the human gut in response to changing environments: An invisible player in the game of health.” Comput Struct Biotechnol J 19 (2021): 752–58. https://doi.org/10.1016/j.csbj.2021.01.007.
       Full Text  Link to Item
    • Davis, Catherine M., Antiño R. Allen, and Dawn E. Bowles. “Consequences of space radiation on the brain and cardiovascular system.” Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis 39, no. 2 (January 2021): 180–218. https://doi.org/10.1080/26896583.2021.1891825.
       Full Text
    • Brown, Zachary D., Muath Bishawi, Jun-Neng Roan, Franklin Lee, Adam Nevo, Michael Watson, and Dawn E. Bowles. “The use of an inexpensive processing aid device (the Mouse PAD) to facilitate rodent tissue banking.” Biotechniques 69, no. 1 (July 2020): 364–68. https://doi.org/10.2144/btn-2019-0069.
       Full Text  Link to Item
    • Stevenson, Mark D., Chandrika Canugovi, Aleksandr E. Vendrov, Takayuki Hayami, Dawn E. Bowles, Karl-Heinz Krause, Nageswara R. Madamanchi, and Marschall S. Runge. “NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.” Antioxid Redox Signal 31, no. 1 (July 1, 2019): 39–58. https://doi.org/10.1089/ars.2018.7548.
       Full Text  Link to Item
    • Bishawi, Muath, Jun-Neng Roan, Carmelo A. Milano, Mani A. Daneshmand, Jacob N. Schroder, Yuting Chiang, Franklin H. Lee, et al. “A normothermic ex vivo organ perfusion delivery method for cardiac transplantation gene therapy.” Sci Rep 9, no. 1 (May 29, 2019): 8029. https://doi.org/10.1038/s41598-019-43737-y.
       Full Text  Link to Item
    • Ren, Linda, Robert A. Holzknecht, Zoie E. Holzknecht, Sanet H. Kotzé, Dawn E. Bowles, Shu S. Lin, Erin A. McKenney, and William Parker. “A mole rat's gut microbiota suggests selective influence of diet on microbial niche space and evolution.” Exp Biol Med (Maywood) 244, no. 6 (April 2019): 471–83. https://doi.org/10.1177/1535370219828703.
       Full Text  Link to Item
    • Beak, Ju Youn, Hong Soon Kang, Wei Huang, Page H. Myers, Dawn E. Bowles, Anton M. Jetten, and Brian C. Jensen. “The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.” Am J Physiol Heart Circ Physiol 316, no. 1 (January 1, 2019): H186–200. https://doi.org/10.1152/ajpheart.00531.2018.
       Full Text  Link to Item
    • Bishawi, Muath, Jeremy Joseph, Chetan Patel, Jacob Schroder, Mani Daneshmand, Dawn Bowles, Joseph Rogers, and Carmelo Milano. “Risk factors for stroke on left ventricular assist devices.” J Card Surg 33, no. 6 (June 2018): 348–52. https://doi.org/10.1111/jocs.13718.
       Full Text  Link to Item
    • Bishawi, Muath, Jun-Neng Roan, Jordan Richards, Zachary Brown, Laura Blue, Mani A. Daneshmand, Jacob N. Schroder, Dawn E. Bowles, and Carmelo A. Milano. “Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart.” J Vis Exp, no. 135 (May 11, 2018). https://doi.org/10.3791/55961.
       Full Text  Link to Item
    • Hayashi, Hiroki, Douglas T. Hess, Rongli Zhang, Keiki Sugi, Huiyun Gao, Bea L. Tan, Dawn E. Bowles, et al. “S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.” Mol Cell 70, no. 3 (May 3, 2018): 473-487.e6. https://doi.org/10.1016/j.molcel.2018.03.034.
       Full Text  Link to Item
    • Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T. Strachan, Zhu-Shan Zhang, et al. “Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.” Jci Insight 2, no. 17 (September 7, 2017). https://doi.org/10.1172/jci.insight.95998.
       Full Text  Link to Item
    • Santacruz, Lucia, Antonio Jose Luis Arciniegas, Marcus Darrabie, Jose G. Mantilla, Rebecca M. Baron, Dawn E. Bowles, Rajashree Mishra, and Danny O. Jacobs. “Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.” Physiol Rep 5, no. 16 (August 2017). https://doi.org/10.14814/phy2.13382.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, Dawn E. Bowles, Syamal D. Bhattacharya, and Paul C. Kuo. “Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.” J Biol Chem 292, no. 3 (January 20, 2017): 1142. https://doi.org/10.1074/jbc.A110.161869.
       Full Text  Link to Item
    • Jensen, Brian C., Scott J. Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, and Monte S. Willis. “Upregulation of autophagy genes and the unfolded protein response in human heart failure.” Int J Clin Exp Med 10, no. 1 (2017): 1051–58.
       Link to Item
    • Feger, Bryan J., J Will Thompson, Laura G. Dubois, Reddy P. Kommaddi, Matthew W. Foster, Rajashree Mishra, Sudha K. Shenoy, et al. “Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.” Sci Rep 6 (September 27, 2016): 34091. https://doi.org/10.1038/srep34091.
       Full Text  Open Access Copy  Link to Item
    • Schechter, Matthew A., Michael J. Watson, Bryan J. Feger, Kevin W. Southerland, Rajashree Mishra, Louis R. Dibernardo, Maragatha Kuchibhatla, et al. “Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.” J Card Fail 22, no. 2 (February 2016): 158–62. https://doi.org/10.1016/j.cardfail.2015.08.339.
       Full Text  Link to Item
    • Ahmad, Tariq, Jacob P. Kelly, Robert W. McGarrah, Anne S. Hellkamp, Mona Fiuzat, Jeffrey M. Testani, Teresa S. Wang, et al. “Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.” J Am Coll Cardiol 67, no. 3 (January 26, 2016): 291–99. https://doi.org/10.1016/j.jacc.2015.10.079.
       Full Text  Link to Item
    • Gaval-Cruz, Meriem, Richard B. Goertz, Daniel J. Puttick, Dawn E. Bowles, Rebecca C. Meyer, Randy A. Hall, Daijin Ko, Carlos A. Paladini, and David Weinshenker. “Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.” Addict Biol 21, no. 1 (January 2016): 35–48. https://doi.org/10.1111/adb.12174.
       Full Text  Link to Item
    • Pratico, Elizabeth D., Bryan J. Feger, Michael J. Watson, Bruce A. Sullenger, Dawn E. Bowles, Carmelo A. Milano, and Smita K. Nair. “RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.” Stem Cells Dev 24, no. 22 (November 15, 2015): 2622–33. https://doi.org/10.1089/scd.2015.0073.
       Full Text  Link to Item
    • Schechter, Matthew A., Kevin W. Southerland, Bryan J. Feger, Dean Linder, Ayyaz A. Ali, Linda Njoroge, Carmelo A. Milano, and Dawn E. Bowles. “An isolated working heart system for large animal models.” J Vis Exp, no. 88 (June 11, 2014). https://doi.org/10.3791/51671.
       Full Text  Open Access Copy  Link to Item
    • Schechter, Matthew A., Michael K. H. Hsieh, Linda W. Njoroge, J Will Thompson, Erik J. Soderblom, Bryan J. Feger, Constantine D. Troupes, et al. “Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.” Plos One 9, no. 8 (2014): e104157. https://doi.org/10.1371/journal.pone.0104157.
       Full Text  Open Access Copy  Link to Item
    • Southerland, Kevin W., Sarah B. Frazier, Dawn E. Bowles, Carmelo A. Milano, and Christopher D. Kontos. “Gene therapy for the prevention of vein graft disease.” Transl Res 161, no. 4 (April 2013): 321–38. https://doi.org/10.1016/j.trsl.2012.12.003.
       Full Text  Link to Item
    • Messina, Emily L., Jeffrey Nienaber, Mani Daneshmand, Nestor Villamizar, Jude Samulski, Carmelo Milano, and Dawn E. Bowles. “Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.” Hum Gene Ther 23, no. 10 (October 2012): 1031–42. https://doi.org/10.1089/hum.2012.066.
       Full Text  Link to Item
    • Li, Chengwen, Nina Diprimio, Dawn E. Bowles, Matthew L. Hirsch, Paul E. Monahan, Aravind Asokan, Joseph Rabinowitz, Mavis Agbandje-McKenna, and R Jude Samulski. “Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.” J Virol 86, no. 15 (August 2012): 7752–59. https://doi.org/10.1128/JVI.00675-12.
       Full Text  Link to Item
    • Piacentino, Valentino, Carmelo A. Milano, Michael Bolanos, Jacob Schroder, Emily Messina, Adam S. Cockrell, Edward Jones, et al. “X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.” Hum Gene Ther 23, no. 6 (June 2012): 635–46. https://doi.org/10.1089/hum.2011.186.
       Full Text  Link to Item
    • Bowles, Dawn E., Scott W. J. McPhee, Chengwen Li, Steven J. Gray, Jade J. Samulski, Angelique S. Camp, Juan Li, et al. “Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.” Mol Ther 20, no. 2 (February 2012): 443–55. https://doi.org/10.1038/mt.2011.237.
       Full Text  Link to Item
    • Sun, Qi-An, Douglas T. Hess, Leonardo Nogueira, Sandro Yong, Dawn E. Bowles, Jerry Eu, Kenneth R. Laurita, Gerhard Meissner, and Jonathan S. Stamler. “Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.” Proc Natl Acad Sci U S A 108, no. 38 (September 20, 2011): 16098–103. https://doi.org/10.1073/pnas.1109546108.
       Full Text  Link to Item
    • Darrabie, Marcus D., Antonio Jose Luis Arciniegas, Rajashree Mishra, Dawn E. Bowles, Danny O. Jacobs, and Lucia Santacruz. “AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes.” Am J Physiol Endocrinol Metab 300, no. 5 (May 2011): E870–76. https://doi.org/10.1152/ajpendo.00554.2010.
       Full Text  Link to Item
    • Villamizar, Nestor R., Jennifer H. Crow, Valentino Piacentino, Louis R. DiBernardo, Mani A. Daneshmand, Dawn E. Bowles, Mark A. Groh, and Carmelo A. Milano. “Reproducibility of left atrial ablation with high-intensity focused ultrasound energy in a calf model.” J Thorac Cardiovasc Surg 140, no. 6 (December 2010): 1381-7.e1. https://doi.org/10.1016/j.jtcvs.2010.08.029.
       Full Text  Link to Item
    • Guo, Hongtao, Zhiyong Mi, Dawn E. Bowles, Syamal D. Bhattacharya, and Paul C. Kuo. “Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.” J Biol Chem 285, no. 48 (November 26, 2010): 37787–96. https://doi.org/10.1074/jbc.M110.161869.
       Full Text  Link to Item
    • Piacentino, Valentino, Michael Bolanos, Jacob Schroder, Emily Messina, Edward Jones, Ava Krol, Nenad Bursac, et al. “X-Linked Inhibitor of Apoptosis Protein (XIAP)-Mediated Attenuation of Apoptosis Using a Novel Cardiac Enhanced Adeno-Associated Viral Vector.” Circulation 122, no. 21 (November 23, 2010).
       Link to Item
    • Mendell, Jerry R., Katherine Campbell, Louise Rodino-Klapac, Zarife Sahenk, Chris Shilling, Sarah Lewis, Dawn Bowles, et al. “Dystrophin immunity in Duchenne's muscular dystrophy.” N Engl J Med 363, no. 15 (October 7, 2010): 1429–37. https://doi.org/10.1056/NEJMoa1000228.
       Full Text  Link to Item
    • Crow, Sheri, Dong Chen, Carmelo Milano, William Thomas, Lyle Joyce, Valentino Piacentino, Riti Sharma, et al. “Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients.” Ann Thorac Surg 90, no. 4 (October 2010): 1263–69. https://doi.org/10.1016/j.athoracsur.2010.04.099.
       Full Text  Link to Item
    • Crow, Sheri, Carmelo Milano, Lyle Joyce, Dong Chen, Gowthami Arepally, Dawn Bowles, William Thomas, and Nestor Villamizar Ortiz. “Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients.” Asaio J 56, no. 5 (September 2010): 441–45. https://doi.org/10.1097/MAT.0b013e3181e5de0a.
       Full Text  Link to Item
    • Chen, Eefei, Mary Lou Everett, Zoie E. Holzknecht, Robert A. Holzknecht, Shu S. Lin, Dawn E. Bowles, and William Parker. “Short-lived alpha-helical intermediates in the folding of beta-sheet proteins.” Biochemistry 49, no. 26 (July 6, 2010): 5609–19. https://doi.org/10.1021/bi100288q.
       Full Text  Open Access Copy  Link to Item
    • Lee, Sean M., Aaron Wyse, Aaron Lesher, Mary Lou Everett, Linda Lou, Zoie E. Holzknecht, John F. Whitesides, et al. “Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days.” Appl Environ Microbiol 76, no. 14 (July 2010): 4655–63. https://doi.org/10.1128/AEM.00358-10.
       Full Text  Link to Item
    • Lima, Brian, Gregory K. W. Lam, Liang Xie, Diana L. Diesen, Nestor Villamizar, Jeffrey Nienaber, Emily Messina, et al. “Endogenous S-nitrosothiols protect against myocardial injury.” Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297–6302. https://doi.org/10.1073/pnas.0901043106.
       Full Text  Link to Item
    • Li, Chengwen, Dawn E. Bowles, Terry van Dyke, and Richard Jude Samulski. “Adeno-associated virus vectors: potential applications for cancer gene therapy.” Cancer Gene Ther 12, no. 12 (December 2005): 913–25. https://doi.org/10.1038/sj.cgt.7700876.
       Full Text  Link to Item
    • McAvin, James C., David E. Bowles, James A. Swaby, Keith W. Blount, Jamie A. Blow, Miguel Quintana, John R. Hickman, Daniel H. Atchley, and Debra M. Niemeyer. “Identification of Aedes aegypti and its respective life stages by real-time polymerase chain reaction.” Mil Med 170, no. 12 (December 2005): 1060–65. https://doi.org/10.7205/milmed.170.12.1060.
       Full Text  Link to Item
    • McAvin, James C., Elizabeth M. Escamilla, Jamie A. Blow, Michael J. Turell, Miguel Quintana, David E. Bowles, James A. Swaby, et al. “Rapid identification of dengue virus by reverse transcription-polymerase chain reaction using field-deployable instrumentation.” Mil Med 170, no. 12 (December 2005): 1053–59. https://doi.org/10.7205/milmed.170.12.1053.
       Full Text  Link to Item
    • Rabinowitz, Joseph E., Dawn E. Bowles, Susan M. Faust, Julie G. Ledford, Scott E. Cunningham, and R Jude Samulski. “Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.” J Virol 78, no. 9 (May 2004): 4421–32. https://doi.org/10.1128/jvi.78.9.4421-4432.2004.
       Full Text  Link to Item
    • Bowles, Dawn E., Joseph E. Rabinowitz, and R Jude Samulski. “Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production.” J Virol 77, no. 1 (January 2003): 423–32. https://doi.org/10.1128/jvi.77.1.423-432.2003.
       Full Text  Link to Item
    • Bowles, D. E., S. K. Kim, and D. J. O’Callaghan. “Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein.” J Virol 74, no. 3 (February 2000): 1200–1208. https://doi.org/10.1128/jvi.74.3.1200-1208.2000.
       Full Text  Link to Item
    • Kim, S. K., D. E. Bowles, and D. J. O’callaghan. “The gamma2 late glycoprotein K promoter of equine herpesvirus 1 is differentially regulated by the IE and EICP0 proteins.” Virology 256, no. 2 (April 10, 1999): 173–79. https://doi.org/10.1006/viro.1999.9608.
       Full Text  Link to Item
    • Bowles, D. E., V. R. Holden, Y. Zhao, and D. J. O’Callaghan. “The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters.” J Virol 71, no. 7 (July 1997): 4904–14. https://doi.org/10.1128/JVI.71.7.4904-4914.1997.
       Full Text  Link to Item
    • Campbell, Brian S., and David E. Bowles. “Human tick bite records in a United States Air Force population, 1989–1992: implications for tick-borne disease risk.” Journal of Wilderness Medicine 5, no. 4 (December 1994): 405–12. https://doi.org/10.1580/0953-9859-5.4.405.
       Full Text
    • Bowles, David E., and O. H. Griffin. “Micromechanics Analysis of Space Simulated Thermal Stresses in Composites. Part I: Theory and Unidirectional Laminates.” Journal of Reinforced Plastics and Composites 10, no. 5 (September 1991): 504–21. https://doi.org/10.1177/073168449101000506.
       Full Text
    • Bowles, David E., and O. H. Griffin. “Micromechanics Analysis of Space Simulated Thermal Stresses in Composites. Part II: Multidirectional Laminates and Failure Predictions.” Journal of Reinforced Plastics and Composites 10, no. 5 (September 1991): 522–39. https://doi.org/10.1177/073168449101000507.
       Full Text
    • BOWLES, D. E., and D. R. TENNEY. “COMPOSITE TUBES FOR THE SPACE STATION TRUSS STRUCTURE.” Sampe Journal 23, no. 3 (May 1, 1987): 49–57.
       Link to Item
    • Bowles, David E., Stephen S. Tompkins, and George F. Sykes. “Electron radiation effects on the thermal expansion of graphite resin composites.” Journal of Spacecraft and Rockets 23, no. 6 (November 1986): 625–29. https://doi.org/10.2514/3.25857.
       Full Text
    • SYKES, G. F., and D. E. BOWLES. “SPACE RADIATION EFFECTS ON THE DIMENSIONAL STABILITY OF A TOUGHENED EPOXY GRAPHITE COMPOSITE.” Sampe Quarterly Society for the Advancement of Material and Process Engineering 17, no. 4 (July 1, 1986): 39–45.
       Link to Item
    • HAGEMAIER, D. J., and D. BOWLES. “EVALUATION OF MAGNETIC PARTICLE INSPECTION OXIDES.” Materials Evaluation 37, no. 11 (January 1, 1979): 47–53.
       Link to Item
    • Wang, Teresa, Emily C. O’Brien, Joseph G. Rogers, Daniel L. Jacoby, Michael E. Chen, Jeffrey M. Testani, Dawn E. Bowles, et al. “Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support.” Asaio J 63, no. 5 (n.d.): 536–41. https://doi.org/10.1097/MAT.0000000000000564.
       Full Text  Link to Item

  • Conference Papers

    • Vekstein, Andrew M., David C. Wendell, Dawn E. Bowles, Sophia DeLuca, Ruorong Yan, Muath Bishawi, Garth Devlin, et al. “Targeted Intra-Coronary Delivery versus Intra-Myocardial Injection of Therapeutics for Myocardial Recovery: A Nanoparticle Image Guided Porcine Study.” In Circulation, Vol. 144, 2021.
       Link to Item
    • Truby, Lauren K., Lydia Kwee, Jessica A. Regan, Dawn E. Bowles, Carmelo A. Milano, Elizabeth Grass, Michael R. Bristow, Robert W. McGarrah, Christopher L. Holley, and Svati H. Shah. “Proteomic Profiles of Diabetic Heart Failure Report on Myocardial Metabolism, Ventricular Hypertrophy, and Endothelial Dysfunction.” In Circulation, Vol. 142, 2020.
       Link to Item
    • Chiang, Y. P., M. Bishawi, C. Wang, M. J. Watson, F. H. Lee, A. Roki, A. Doty, et al. “Successful Gene Delivery to Cardiac Allograft with Adeno-Associated Viral Vector Using Ex Vivo Storage Perfusion Platform.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S360–61, 2020. https://doi.org/10.1016/j.healun.2020.01.434.
       Full Text
    • Bishawi, Muath, Jun-Neng Roan, Carmelo A. Milano, Mani A. Daneshmand, Jacob N. Schroder, Zachary D. Brown, Adam Nevo, et al. “Wide Spread Adenoviral Vector Delivery to a Cardiac Allograft Utilizing an Ex Vivo Perfusion Storage Strategy.” In Molecular Therapy, 26:69–69. CELL PRESS, 2018.
       Link to Item
    • Watson, Michael, Deborah Cholon, Samuel Perez-Tamayo, Vayun Agrawal, Yoichiro Shibata, Martina Gentzsch, and Dawn Bowles. “Cystic Fibrosis Transmembrane Conductance Regulator Is Heterologously Expressed in Human Heart.” In Faseb Journal, Vol. 32. FEDERATION AMER SOC EXP BIOL, 2018.
       Link to Item
    • Stevenson, Mark D., Chandrika Canugovi, Aleksandr E. Vendrov, Dawn E. Bowles, Nageswara R. Madamanchi, and Marschall S. Runge. “NADPH Oxidase 4 Contributes to Ischemic Cardiomyopathy by Activating Soluble Epoxide Hydrolase.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
       Link to Item
    • Jean-Charles, Pierre-Yves, Samuel Mon-Wei Yu, Lan Mao, Reddy Perra Kommadi, Zhushan Zhang, Jonathan Stiber, Dawn Bowles, et al. “Beta(1)-Adrenergic Receptor-induced Cardiac Contractility is dependent on MDM2-mediated GRK2 Turnover.” In Circulation Research, 119:E162–63. LIPPINCOTT WILLIAMS & WILKINS, 2016.
       Link to Item
    • Bishawi, M., J. Joseph, B. Yerokun, D. Ranney, P. Winterton, J. Schroder, M. Daneshmand, D. Bowles, J. Rogers, and C. Milano. “Incidence and Outcomes After Stroke on Rotary Flow Ventricular Assist Device Support.” In The Journal of Heart and Lung Transplantation, 35:S262–63. Elsevier BV, 2016. https://doi.org/10.1016/j.healun.2016.01.745.
       Full Text
    • Schechter, M. A., K. W. Southerland, B. J. Feger, L. Njoroge, D. Linder, D. E. Bowles, and C. A. Milano. “Functional and Biochemical Assessment of Porcine Hearts After Simulated Donation After Circulatory Death.” In The Journal of Heart and Lung Transplantation, 34:S150–S150. Elsevier BV, 2015. https://doi.org/10.1016/j.healun.2015.01.403.
       Full Text
    • Schechter, M. A., K. W. Southerland, M. J. Watson, B. J. Feger, R. Mishra, J. N. Schroder, L. R. Dibernardo, et al. “Cardiac Troponin I Levels in Preservation Solution Predict Primary Graft Dysfunction After Heart Transplant.” In The Journal of Heart and Lung Transplantation, 34:S268–S268. Elsevier BV, 2015. https://doi.org/10.1016/j.healun.2015.01.750.
       Full Text
    • Wang, Teresa, Emily O’Brien, Marc Samsky, Joseph Rogers, Adrian Hernandez, Dawn Bowles, G Michael Felker, Chetan Patel, and Tariq Ahmad. “Effects of Left Ventricular Assist Device Support on microRNA Levels.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.
       Link to Item
    • Ahmad, Tariq, Teresa Wang, Marc Samsky, Damian Craig, Gary M. Felker, Adrian Hernandez, Joseph Rogers, et al. “Effects of Left Ventricular Assist Device Placement on Biomarkers of Cardiovascular Stress, Fibrosis, Fluid Homeostasis, Mitochondrial Function, Metabolism, and Endothelial Dysfunction.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
       Link to Item
    • Foster, Matthew, J Will Thompson, Michael Forrester, Yonggang Sha, Dawn Bowles, M Arthur Moseley, and Harvey Marshall. “Quantitative proteomics of the cytokine-modulated NOS2 interactome in airway epithelial cells.” In Nitric Oxide, 27:S13–S13. Elsevier BV, 2012. https://doi.org/10.1016/j.niox.2012.04.047.
       Full Text
    • Foster, M. W., Z. T. Kelleher, M. T. Forrester, D. E. Bowles, M. A. Moseley, and H. E. Marshall. “Quantitative Proteomics Of The Cytokine-Modulated Nos2 Interactome In Airway Epithelium.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.
       Link to Item
    • Piacentino III, P., J. W. Thompson, E. J. Soderblom, M. Foster, V. A. Burns, J. G. Rogers, C. A. Milano, M. A. Moseley, and D. E. Bowles. “Ischemic Human Heart Failure is Associated With Decreased Phosphorylation of Pyruvate Dehydrogenase and Triosephosphate Isomerase: Proteomic Evidence Supporting Carbohydrate Utilization Preference in the End-Stage Failing Ischemic Heart.” In Circulation, Vol. 122, 2010.
       Link to Item
    • Campbell, Katherine, Louise Rodino-Klapac, Zarife Sahenk, Chris Shilling, Sarah Lewis, Dawn Bowles, Steven Gray, et al. “Revertant muscle fibers expressing dystrophin do not tolerize the immune system in Duchenne muscular dystrophy: lessons learned from a Phase I clinical trial.” In Journal of Immunology, Vol. 184. AMER ASSOC IMMUNOLOGISTS, 2010.
       Link to Item
    • Mendell, Jerry, Katherine Campbell, Louise Rodino-Klapac, Zarife Sahenk, Christopher Shilling, Sarah Lewis, Dawn Bowles, et al. “Transient Expression of a Therapeutic Dystrophin Transgene in Duchenne Muscular Dystrophy Revealed by T Cell Mediated Immunity.” In Neurology, 74:A111–A111. LIPPINCOTT WILLIAMS & WILKINS, 2010.
       Link to Item
    • Bowles, Dawn E., Chengwen Li, Paul E. Monahan, Joseph E. Rabinowitz, Mavis McKenna, and Jude Samulski. “1064. Haute Couture Vectors: Solving Clinical Problems with Custom Designed AAV Vectors.” In Molecular Therapy, 13:S408–S408. Elsevier BV, 2006. https://doi.org/10.1016/j.ymthe.2006.08.1162.
       Full Text
    • Faust, S. M., D. E. Bowles, S. E. Cunningham, J. E. Rabinowitz, and R. J. Samulski. “Universal purification of AAV serotypes 1-5 modified to contain a heparin binding epitope.” In Molecular Therapy, 9:S36–S36. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.
       Link to Item
    • Grieger, J. C., J. E. Rabinowitz, D. E. Bowles, and R. J. Samulski. “Role of Vp2 in AAV packaging.” In Molecular Therapy, 9:S7–S7. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.
       Link to Item
    • Rabinowitz, J. E., D. E. Bowles, S. M. Faust, J. G. Ledford, S. E. Cunningham, and R. J. Samulski. “The transcapsidation of AAV serotypes.” In Molecular Therapy, 9:S8–S8. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.
       Link to Item
    • Tompkins, Stephen S., Joan G. Funk, David E. Bowles, Timothy W. Towell, and John W. Connell. “<title>Composite materials for precision space reflector panels</title>.” In Spie Proceedings. SPIE, 1992. https://doi.org/10.1117/12.138000.
       Full Text
    • BOWLES, D. E., S. S. TOMPKINS, and J. G. FUNK. “RESIDUAL THERMAL-STRESSES IN COMPOSITES FOR DIMENSIONALLY STABLE SPACECRAFT APPLICATIONS.” In Proceedings of the Vii International Congress on Experimental Mechanics, Vols 1 and 2, 1211–19. SOC EXPERIMENTAL MECHANICS INC, 1992.
       Link to Item
    • Tompkins, Stephen S., David E. Bowles, Joan G. Funk, J. A. Lavoie, and Timothy W. Towell. “Development of composite materials for spacecraft precision-reflector panels.” In Spie Proceedings. SPIE, 1990. https://doi.org/10.1117/12.21533.
       Full Text
    • BOWLES, D. E., and O. H. GRIFFIN. “ANALYSIS OF THERMAL-STRESSES IN POLYMER MATRIX COMPOSITES.” In Tomorrows Materials : Today, Book 1 and 2, edited by G. A. ZAKRZEWSKI, D. MAZENKO, S. T. PETERS, and C. D. DEAN, 34:575–84. SOC ADVANCEMENT MATERIAL & PROCESS ENGINEERING, 1989.
       Link to Item
    • DERSTINE, M. S., M. J. PINDERA, and D. E. BOWLES. “EXPERIMENTAL ANALYTICAL CHARACTERIZATION OF COMPOSITE TUBES UNDER COMBINED LOADING.” In Proceedings of the 1989 Sem Spring Conference on Experimental Mechanics, 483–90. SOC EXPERIMENTAL MECHANICS INC, 1989.
       Link to Item
    • BOWLES, D. “X-RAY INSPECTION TECHNIQUES FOR LAMINATED GRAPHITE HONEYCOMB COMPOSITES.” In Materials Evaluation, 41:S20–S20. AMER SOC NON-DESTRUCTIVE TEST, 1983.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.