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Debra Lynn Silver

Vice Chair for Faculty Affairs
Cell Biology
466A Nanaline Duke Building, 307 Research Drive, Durham, NC 27710
466A Nanaline Duke Building, 307 Research Drive, Durham, NC 27710

Scholarly Works - Book sections


Genomic basis of human-specific brain features

Book section · January 1, 2026 The modern human brain has undergone remarkable evolution since our divergence from archaic hominins and other apes, resulting in unique neuroanatomy, neuronal circuitry, and cell composition. These features underpin our extraordinary cognitive abilities a ... Full text Cite

Posttranscriptional Control of Brain Development

Book section · January 1, 2023 The neocortex is among the newest evolutionary additions to the human brain, consistent with its function in higher-level processes such as cognition. This structure develops through neural progenitor proliferation, neural differentiation, neuronal migrati ... Full text Cite

Post-transcriptional Gene Regulation During Cortical Development

Book section · January 1, 2022 Higher-order cognitive function in mammals is derived from the activity of the cerebral cortex. This brain structure is among the most complex tissues in the body, and its development requires multiple layers of regulation. The network of transcription fac ... Full text Cite

Posttranscriptional and translational control of neurogenesis

Book section · January 1, 2020 The sequential events of neurogenesis are orchestrated by diverse layers of molecular regulation, including posttranscriptional control. Notably, while a great deal is known about transcriptional and signaling hierarchies in neurogenesis, in comparison, we ... Full text Cite