Debra Lynn Silver

Journal article Neuron · January 6, 2016 Featured Work Embryonic neocortical development depends on balanced production of progenitors and neurons. Genetic mutations disrupting progenitor mitosis frequently impair neurogenesis; however, the link between altered mitosis and cell fate remains poorly understood. ... Full text Link to item Cite

Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.

Journal article J Neurosci · May 6, 2015 Featured Work The cerebral cortex is built during embryonic neurogenesis, a period when excitatory neurons are generated from progenitors. Defects in neurogenesis can cause acute neurodevelopmental disorders, such as microcephaly (reduced brain size). Altered dosage of ... Full text Link to item Cite

Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.

Journal article Curr Biol · March 16, 2015 Featured Work The human neocortex differs from that of other great apes in several notable regards, including altered cell cycle, prolonged corticogenesis, and increased size [1-5]. Although these evolutionary changes most likely contributed to the origin of distinctive ... Full text Open Access Link to item Cite