Dennis Ko | Scholars@Duke

Dennis Ko
Associate Professor in Molecular Genetics and Microbiology

Using Pathogens to Decipher Genetic Variation Connecting Cell Biology and Disease Susceptibility
Despite improvements in public health, advancements in vaccines, and the development of many classes of antibiotics, infectious disease is still responsible for over a quarter of all deaths worldwide. However, even for the most devastating of pandemics, individuals demonstrate a large variability in the severity of infection. The long-term goal of the lab is to understand the genetic basis for differences in susceptibility to infection and related inflammatory disorders. We approach this question through a combination of experimental and computational approaches that combine high-throughput cell biology with quantitative human genetics. The identified genetic differences serve as the starting point for exploring new cell biology and human disease susceptibility genes.

Current Appointments & Affiliations

Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2020
Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Associate Professor in Medicine, Medicine, Clinical Science Departments 2022
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017

Contact Information

0049 CARL Building, Box 3053, 213 Research Drive, Durham, NC 27710
dennis.ko@duke.edu (919) 684-5834
Duke Molecular Genetics and Microbiology Profile

Background
Education, Training, & Certifications
- M.D., Stanford University 2005
- Ph.D., Stanford University 2003
Previous Appointments & Affiliations
- Assistant Professor in the Department of Medicine, Medicine, Clinical Science Departments 2012 - 2022
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2012 - 2020
Recognition
In the News
- SEP 8, 2022
  
  Chlamydia’s Stealthy Cloaking Device Identified
- MAR 8, 2017
  
  Researchers Identify Biomarker That Predicts Death in Sepsis Patients
- SEP 15, 2015
  
  Specific Fatty Acids May Worsen Crohn’s Disease
Awards & Honors
- ICAAC Young Investigator Awards. American Society for Microbiology. 2014
Expertise
Subject Headings
- Muser Mentor
Research
Selected Grants
- Genetic Contributors to the Impact of Sex on Heterogeneity in Flu Infection awarded by National Institutes of Health 2022 - 2027
- Characterization of a Novel E. coli Type III Secretion System Associated with Increased Patient Mortality awarded by National Institutes of Health 2022 - 2027
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Linking human TB genetic susceptibility loci to granuloma biology awarded by National Institutes of Health 2022 - 2026
- Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITY awarded by National Institutes of Health 2015 - 2025
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Human Genetic Variation Regulating Transcriptional Response and Cellular Susceptibility to Influenza awarded by National Institutes of Health 2021 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- SALMONELLA HIJACKING OF STAT3 AND CONSEQUENCES FOR DISEASE awarded by National Institutes of Health 2019 - 2022
- Mechanisms of methylthioadenosine signaling during Salmonella infection awarded by National Institutes of Health 2019 - 2022
- Regulation of Salmonella virulence by interspecies methylthioadenosine signaling awarded by National Institutes of Health 2019 - 2022
- Host-Directed Therapy to Circumvent Immune Evasion by Leishmania major awarded by Burroughs Wellcome Fund 2019 - 2021
- Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections awarded by University of Maryland, Baltimore 2015 - 2021
- STAT3-dependent manipulation of host transcription and immune responses by Salmonella awarded by National Institutes of Health 2019 - 2021
- AN ATLAS OF SHARED GENETIC ARCHITECTURE CONNECTING CELL BIOLOGY AND HUMAN DISEASE awarded by National Institutes of Health 2018 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections awarded by University of Maryland 2009 - 2019
- Characterization of a novel Salmonella regulator of IL-10 production and its role in pathogenesis awarded by National Institutes of Health 2016 - 2018
- A role for pathogen-induced IL-10 production in susceptibility to MS awarded by National Multiple Sclerosis Society 2014 - 2015
- Functional genomics of human variation to Salmonella invasion awarded by National Institutes of Health 2012 - 2015
- missing activity
- missing activity
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gibbs, Kyle D., Liuyang Wang, Zhuo Yang, Caroline E. Anderson, Jeffrey S. Bourgeois, Yanlu Cao, Margaret R. Gaggioli, et al. “Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation.” Cell Genom 3, no. 5 (May 10, 2023): 100290. https://doi.org/10.1016/j.xgen.2023.100290.
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  - Wu, Jieyu, Liuyang Wang, John F. Ervin, Shih-Hsiu J. Wang, Erik Soderblom, Dennis Ko, and Dong Yan. “GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans.” Sci Adv 8, no. 51 (December 21, 2022): eadc9236. https://doi.org/10.1126/sciadv.adc9236.
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  - Walsh, Stephen C., Jeffrey R. Reitano, Mary S. Dickinson, Miriam Kutsch, Dulcemaria Hernandez, Alyson B. Barnes, Benjamin H. Schott, et al. “The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.” Cell Host Microbe 30, no. 12 (December 14, 2022): 1671-1684.e9. https://doi.org/10.1016/j.chom.2022.08.008.
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  - Gibbs, Kyle D., Benjamin H. Schott, and Dennis C. Ko. “The Awesome Power of Human Genetics of Infectious Disease.” Annu Rev Genet 56 (November 30, 2022): 41–62. https://doi.org/10.1146/annurev-genet-080320-010449.
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  - Schott, Benjamin H., Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, et al. “Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus.” Cell Genom 2, no. 11 (November 9, 2022). https://doi.org/10.1016/j.xgen.2022.100207.
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  - Oswalt, Cameron J., Rami N. Al-Rohil, Bala Theivanthiran, Tarek Haykal, April K. S. Salama, Nicholas C. DeVito, Alisha Holtzhausen, Dennis C. Ko, and Brent A. Hanks. “Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multiple Spontaneous Regressions and Immune-related Adverse Events.” J Immunother 45, no. 6 (July 2022): 284–90. https://doi.org/10.1097/CJI.0000000000000425.
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  - Bourgeois, Jeffrey S., Caroline E. Anderson, Liuyang Wang, Jennifer L. Modliszewski, Wei Chen, Benjamin H. Schott, Nicolas Devos, and Dennis C. Ko. “Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions.” Mbio 13, no. 3 (June 28, 2022): e0346421. https://doi.org/10.1128/mbio.03464-21.
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  - Barnes, Alyson B., Rachel M. Keener, Benjamin H. Schott, Liuyang Wang, Raphael H. Valdivia, and Dennis C. Ko. “Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis.” Hgg Adv 3, no. 1 (January 13, 2022): 100071. https://doi.org/10.1016/j.xhgg.2021.100071.
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  - Antonia, Alejandro L., Alyson B. Barnes, Amelia T. Martin, Liuyang Wang, and Dennis C. Ko. “Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor.” Plos Negl Trop Dis 15, no. 10 (October 2021): e0009224. https://doi.org/10.1371/journal.pntd.0009224.
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  - Bourgeois, Jeffrey S., Liuyang Wang, Agustin F. Rabino, Jeffrey Everitt, Monica I. Alvarez, Sahezeel Awadia, Erika S. Wittchen, Rafael Garcia-Mata, and Dennis C. Ko. “ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.” Plos Pathog 17, no. 7 (July 2021): e1009713. https://doi.org/10.1371/journal.ppat.1009713.
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  - Wang, Liuyang, Thomas J. Balmat, Alejandro L. Antonia, Florica J. Constantine, Ricardo Henao, Thomas W. Burke, Andy Ingham, et al. “An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.” Genome Med 13, no. 1 (May 17, 2021): 83. https://doi.org/10.1186/s13073-021-00904-z.
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  - Bourgeois, Jeffrey S., Clare M. Smith, and Dennis C. Ko. “These Are the Genes You're Looking For: Finding Host Resistance Genes.” Trends Microbiol 29, no. 4 (April 2021): 346–62. https://doi.org/10.1016/j.tim.2020.09.006.
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  - Antonia, Alejandro, Amelia Martin, Liuyang Wang, and Dennis Ko. “Variation inLeishmaniachemokine suppression driven by diversification of the GP63 virulence factor,” 2021. https://doi.org/10.1101/2021.02.01.429140.
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  - Bourgeois, Jeffrey, Caroline Anderson, Liuyang Wang, Jennifer Modliszewski, Wei Chen, Benjamin Schott, Nicolas Devos, and Dennis Ko. “Integration of the Salmonella Typhimurium methylome and transcriptome reveals DNA methylation and transcriptional regulation are largely decoupled under virulence-related conditions,” 2021. https://doi.org/10.1101/2021.11.11.468322.
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  - Wang, Liuyang, Thomas J. Balmat, Alejandro L. Antonia, Florica J. Constantine, Ricardo Henao, Thomas W. Burke, Andy Ingham, et al. “An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.” Medrxiv, December 22, 2020. https://doi.org/10.1101/2020.12.20.20248572.
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  - Schott, Benjamin H., Alejandro L. Antonia, Liuyang Wang, Kelly J. Pittman, Barbara S. Sixt, Alyson B. Barnes, Raphael H. Valdivia, and Dennis C. Ko. “Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease.” Sci Rep 10, no. 1 (October 26, 2020): 18269. https://doi.org/10.1038/s41598-020-75129-y.
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  - Gibbs, Kyle D., Erica J. Washington, Sarah L. Jaslow, Jeffrey S. Bourgeois, Matthew W. Foster, Robyn Guo, Richard G. Brennan, and Dennis C. Ko. “The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3.” Cell Host Microbe 27, no. 1 (January 8, 2020): 129-139.e4. https://doi.org/10.1016/j.chom.2019.11.012.
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  - Antonia, Alejandro L., and Dennis C. Ko. “Leishmaniasis: A spectrum of diseases shaped by evolutionary pressures across diverse life cycle.” Evol Med Public Health 2020, no. 1 (2020): 139–40. https://doi.org/10.1093/emph/eoaa032.
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  - Bourgeois, Jeffrey, Liuyang Wang, Monica Alvarez, Jeffrey Everitt, Sahezeel Awadia, Erika Wittchen, Rafael Garcia-Mata, and Dennis Ko. “ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice,” 2020. https://doi.org/10.1101/2020.12.30.424811.
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  - Hale, Andrew, Dan Zhou, Rebecca Sale, Lisa Bastarache, Liuyang Wang, Sandra Zinkel, Steven Schiff, Dennis Ko, and Eric Gamazon. “The genetic architecture of human infectious diseases and pathogen-induced cellular phenotypes,” 2020. https://doi.org/10.1101/2020.07.19.20157404.
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  - Antonia, Alejandro, Monica Alvarez, Esme Trahair, Kyle Gibbs, Kelly Pittman, Alyson Barnes, Jeffrey Smith, et al. “Pathogen-encoded evasion of CXCL10 and T cell responses,” February 22, 2019. https://doi.org/10.1101/557876.
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  - Antonia, Alejandro L., Kyle D. Gibbs, Esme D. Trahair, Kelly J. Pittman, Amelia T. Martin, Benjamin H. Schott, Jeffrey S. Smith, et al. “Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.” Front Cell Infect Microbiol 9 (2019): 280. https://doi.org/10.3389/fcimb.2019.00280.
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  - Bourgeois, Jeffrey S., Daoguo Zhou, Teresa L. M. Thurston, James J. Gilchrist, and Dennis C. Ko. “Methylthioadenosine Suppresses Salmonella Virulence.” Infect Immun 86, no. 9 (September 2018). https://doi.org/10.1128/IAI.00429-18.
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  - Wang, Liuyang, Kelly J. Pittman, Jeffrey R. Barker, Raul E. Salinas, Ian B. Stanaway, Graham D. Williams, Robert J. Carroll, et al. “An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.” Cell Host Microbe 24, no. 2 (August 8, 2018): 308-323.e6. https://doi.org/10.1016/j.chom.2018.07.007.
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  - Jaslow, Sarah L., Kyle D. Gibbs, W Florian Fricke, Liuyang Wang, Kelly J. Pittman, Mark K. Mammel, Joshua T. Thaden, et al. “Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.” Cell Rep 23, no. 12 (June 19, 2018): 3525–36. https://doi.org/10.1016/j.celrep.2018.05.072.
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  - Alvarez, Monica I., and Dennis C. Ko. “Reply to Gilchrist et al.: Possible roles for VAC14 in multiple infectious diseases.” Proc Natl Acad Sci U S A 115, no. 16 (April 17, 2018): E3604–5. https://doi.org/10.1073/pnas.1803533115.
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  - Antonia, Alejandro L., Liuyang Wang, and Dennis C. Ko. “A real-time PCR assay for quantification of parasite burden in murine models of leishmaniasis.” Peerj 6 (2018): e5905. https://doi.org/10.7717/peerj.5905.
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  - Corona, Erik, Liuyang Wang, Dennis Ko, and Chirag J. Patel. “Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.” Plos One 13, no. 5 (2018): e0196676. https://doi.org/10.1371/journal.pone.0196676.
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  - Alvarez, Monica I., Luke C. Glover, Peter Luo, Liuyang Wang, Elizabeth Theusch, Stefan H. Oehlers, Eric M. Walton, et al. “Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.” Proc Natl Acad Sci U S A 114, no. 37 (September 12, 2017): E7746–55. https://doi.org/10.1073/pnas.1706070114.
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  - Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.
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  - Wang, Liuyang, Emily R. Ko, James J. Gilchrist, Kelly J. Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, et al. “Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.” Sci Adv 3, no. 3 (March 2017): e1602096. https://doi.org/10.1126/sciadv.1602096.
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  - Oehlers, Stefan H., Maria Vega Flores, Christopher J. Hall, Liuyang Wang, Dennis C. Ko, Kathryn E. Crosier, and Philip S. Crosier. “A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.” Febs J 284, no. 3 (February 2017): 402–13. https://doi.org/10.1111/febs.13976.
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  - Pittman, Kelly J., Luke C. Glover, Liuyang Wang, and Dennis C. Ko. “The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease.” Plos Pathog 12, no. 7 (July 2016): e1005680. https://doi.org/10.1371/journal.ppat.1005680.
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  - Jaslow, Sarah, Liuyang Wang, and Dennis Ko. “Contribution to Virulence of a Novel Anti-inflammatory Effector in Salmonella enterica.” Open Forum Infect Dis 2, no. Suppl 1 (December 2015): 693. https://doi.org/10.1093/ofid/ofv131.68.
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  - McCauliff, Leslie A., Zhi Xu, Ran Li, Sarala Kodukula, Dennis C. Ko, Matthew P. Scott, Peter C. Kahn, and Judith Storch. “Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.” J Biol Chem 290, no. 45 (November 6, 2015): 27321–31. https://doi.org/10.1074/jbc.M115.667469.
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  - Wang, Liuyang, Stefan H. Oehlers, Scott T. Espenschied, John F. Rawls, David M. Tobin, and Dennis C. Ko. “CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.” Genome Biol 16, no. 1 (September 15, 2015): 190. https://doi.org/10.1186/s13059-015-0722-1.
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  - Lee, Soo Chan, Alicia Li, Silvia Calo, Makoto Inoue, Nam K. Tonthat, Judith M. Bain, Johanna Louw, et al. “Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.” Mol Microbiol 97, no. 5 (September 2015): 844–65. https://doi.org/10.1111/mmi.13071.
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  - Gao, Dahai, Dennis C. Ko, Xinmin Tian, Guang Yang, and Liuyang Wang. “Expression Divergence of Duplicate Genes in the Protein Kinase Superfamily in Pacific Oyster.” Evol Bioinform Online 11, no. Suppl 1 (2015): 57–65. https://doi.org/10.4137/EBO.S30230.
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  - Lee, Soo Chan, R Blake Billmyre, Alicia Li, Sandra Carson, Sean M. Sykes, Eun Young Huh, Piotr Mieczkowski, Dennis C. Ko, Christina A. Cuomo, and Joseph Heitman. “Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt.” Mbio 5, no. 4 (July 8, 2014): e01390–e01314. https://doi.org/10.1128/mBio.01390-14.
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  - Ko, Dennis C., and Sarah L. Jaslow. “The marriage of quantitative genetics and cell biology: a novel screening approach reveals people have genetically encoded variation in microtubule stability.” Bioarchitecture 4, no. 2 (2014): 58–61. https://doi.org/10.4161/bioa.28481.
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  - Salinas, Raul E., Cassandra Ogohara, Monica I. Thomas, Kajal P. Shukla, Samuel I. Miller, and Dennis C. Ko. “A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death.” Mol Biol Cell 25, no. 1 (January 2014): 76–86. https://doi.org/10.1091/mbc.E13-06-0294.
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  - Ko, Dennis C., and Thomas J. Urban. “Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS.” Plos Pathog 9, no. 8 (2013): e1003424. https://doi.org/10.1371/journal.ppat.1003424.
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  - Tobin, David M., Francisco J. Roca, John P. Ray, Dennis C. Ko, and Lalita Ramakrishnan. “An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.” Plos One 8, no. 7 (2013): e67828. https://doi.org/10.1371/journal.pone.0067828.
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  - Ko, Dennis C., Eric R. Gamazon, Kajal P. Shukla, Richard A. Pfuetzner, Dale Whittington, Tarah D. Holden, Mitchell J. Brittnacher, et al. “Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.” Proc Natl Acad Sci U S A 109, no. 35 (August 28, 2012): E2343–52. https://doi.org/10.1073/pnas.1206701109.
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  - Tobin, David M., Francisco J. Roca, Sungwhan F. Oh, Ross McFarland, Thad W. Vickery, John P. Ray, Dennis C. Ko, et al. “Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.” Cell 148, no. 3 (February 3, 2012): 434–46. https://doi.org/10.1016/j.cell.2011.12.023.
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  - McElwain, M. A., D. C. Ko, M. D. Gordon, H. Fyrst, J. D. Saba, and R. Nusse. “A suppressor/enhancer screen in Drosophila reveals a role for Wnt-mediated lipid metabolism in primordial germ cell migration.” Plos One 6, no. 11 (2011). https://doi.org/10.1371/journal.pone.0026993.
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  - McElwain, Mark A., Dennis C. Ko, Michael D. Gordon, Henrik Fyrst, Julie D. Saba, and Roel Nusse. “A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.” Plos One 6, no. 11 (2011): e26993. https://doi.org/10.1371/journal.pone.0026993.
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  - Vinh, Dani B. N., Dennis C. Ko, Richard A. Rachubinski, John D. Aitchison, and Samuel I. Miller. “Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.” Mol Biol Cell 21, no. 20 (October 15, 2010): 3567–77. https://doi.org/10.1091/mbc.E10-06-0482.
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  - Fong, Christine, Dennis C. Ko, Michael Wasnick, Matthew Radey, Samuel I. Miller, and Mitchell Brittnacher. “GWAS analyzer: integrating genotype, phenotype and public annotation data for genome-wide association study analysis.” Bioinformatics 26, no. 4 (February 15, 2010): 560–64. https://doi.org/10.1093/bioinformatics/btp714.
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  - Ko, Dennis C., Kajal P. Shukla, Christine Fong, Michael Wasnick, Mitchell J. Brittnacher, Mark M. Wurfel, Tarah D. Holden, et al. “A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease.” Am J Hum Genet 85, no. 2 (August 2009): 214–27. https://doi.org/10.1016/j.ajhg.2009.07.012.
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  - Ko, Emily Ray, Dennis Ko, Carolyn Chen, and Joseph S. Lipsick. “A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.” Mol Cancer 7 (October 7, 2008): 77. https://doi.org/10.1186/1476-4598-7-77.
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  - Ko, D. C., L. Milenkovic, S. M. Beier, H. Manuel, J. A. Buchanan, and M. P. Scott. “Cell-autonomous death of cerebellar purkinje neurons with autophagy in niemann-pick type C disease.” Plos Genetics 1, no. 1 (July 1, 2005): 0081–0095. https://doi.org/10.1371/journal.pgen.0010007.
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  - Ko, Dennis C., Jonathan Binkley, Arend Sidow, and Matthew P. Scott. “The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.” Proc Natl Acad Sci U S A 100, no. 5 (March 4, 2003): 2518–25. https://doi.org/10.1073/pnas.0530027100.
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  - Ko, D. C., M. D. Gordon, J. Y. Jin, and M. P. Scott. “Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.” Mol Biol Cell 12, no. 3 (March 2001): 601–14. https://doi.org/10.1091/mbc.12.3.601.
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  - Ko, D. C., M. T. Marr, J. Guo, and J. W. Roberts. “A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.” Genes Dev 12, no. 20 (October 15, 1998): 3276–85. https://doi.org/10.1101/gad.12.20.3276.
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  - Roberts, J. W., W. Yarnell, E. Bartlett, J. Guo, M. Marr, D. C. Ko, H. Sun, and C. W. Roberts. “Antitermination by bacteriophage lambda Q protein.” Cold Spring Harb Symp Quant Biol 63 (1998): 319–25. https://doi.org/10.1101/sqb.1998.63.319.
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- Conference Papers
  - Maeso-Díaz, Raquel, Kuo Du, Christopher Pan, Cynthia D. Guy, Seh Hoon Oh, Tianyi Chen, Liuyang Wang, et al. “Targeting senescent hepatocytes using the THBD-PAR1 inhibitor Vorapaxar ameliorates NAFLD progression.” In Hepatology, 2023. https://doi.org/10.1097/HEP.0000000000000401.
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  - Huang, Hsin-I, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, et al. “Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.” In Front Immunol, 12:661290, 2021. https://doi.org/10.3389/fimmu.2021.661290.
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  - Feng, Liping, Alex Antonia, Amy Murtha, and Dennis Ko. “Racial Disparity in Ureaplasma Parvum Induced Inflammatory Responses.” In Reproductive Sciences, 24:174A-174A. SAGE PUBLICATIONS INC, 2017.
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  - Wang, L., M. I. Alvarez, L. C. Glover, K. J. Pittman, K. D. Gibbs, and D. C. Ko. “The Hi-HOST Phenome Project: Interpreting human genetic diversity through high-throughput cell biology.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.
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- Datasets
  - Wang, Liuyang, Dennis Ko, and Benjamin Schott. “Data from: Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus.,” n.d. https://doi.org/10.7924/r4g163n0s.
    Data Access
- Preprints
  - Gibbs, Kyle D., Liuyang Wang, Caroline E. Anderson, Jeffrey S. Bourgeois, Yanlu Cao, Margaret R. Gaggioli, Rosa Puertollano, and Dennis C. Ko. “Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation.” Cold Spring Harbor Laboratory, May 8, 2022. https://doi.org/10.1101/2022.05.08.491078.
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  - Schott, Benjamin H., Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, et al. “Single-cell genome-wide association reveals a nonsynonymous variant inERAP1confers increased susceptibility to influenza virus.” Cold Spring Harbor Laboratory, January 30, 2022. https://doi.org/10.1101/2022.01.30.478319.
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Teaching & Mentoring
Recent Courses
- MGM 293: Research Independent Study I 2023
- MGM 582: Microbial Pathogenesis 2023
- MGM 582: Microbial Pathogenesis 2022
- MGM 593: Research Independent Study 2022
- MGM 293: Research Independent Study I 2021
- MGM 593: Research Independent Study 2021

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Datasets

Preprints

Recent Courses