Scholarly Works - Book sections
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January 1, 2021
Cardiac arrest and ischemic stroke can lead to severe brain dysfunction, due to metabolic stress and loss of protein homeostasis (proteostasis). Further, both metabolic resilience and proteostasis deteriorate with aging, which renders cells inefficient in ...
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January 1, 2021
Pediatric critical care medicine is a discipline dedicated to the care of the critically ill child, focusing on the sick child as a whole and including the impact of disease on all organ systems. Becoming a master in our specialty hinges on lifelong learni ...
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April 21, 2016
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Book section
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January 1, 2007
The ability to perform either multineuron or local field/EEG recordings from the nervous system is a critical requirement to develop a new generation of neuroprosthetics that can sense the brain’s intent for action (Nicolelis 2001, 2003). This form of sens ...
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January 1, 2005
Transmission of signals across synapses is the central component of nervous system function (Bennett and Kearns, 2000; Manwani and Koch, 2000). Primarily, such synaptic transmission is mediated by chemical neurotransmitter substances that are released into ...
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Book section
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January 1, 2004
Each year 4.6 million people die from stroke worldwide and 75% of these cases occur in industrialized countries.1 In the U.S., stroke is the third leading cause of mortality, with 4.7 million survivors, 15 to 30% of whom are left with permanent disabilitie ...
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January 1, 2004
Neuroprosthetics encompasses a wide variety of interfaces with the nervous system, usually considered in the context of clinical abnormalities or disease. The concept stems from clinical concerns about functional independence and integration of individuals ...
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January 1, 2004
Mechanisms of epilepsy have been explored through a variety of animal models as well as detailed human studies, for more than 70 years.1-3 Through the animal models, a large number of contributing factors leading to epilepsy have been demonstrated, includi ...
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January 1, 2004
Spine therapeutics and surgery for spine diseases have undergone long development periods - spine surgeries, particularly laminectomies, have been performed for over a century. Hypotheses concerning spine diseases are now undergoing radical revamping based ...
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January 1, 2004
The goal of this chapter is to assess how close the hypothesis of neural grafting to enhance nervous system function may be to clinical reality, and the problems yet to be resolved before it is applicable clinically.1-5 This chapter focuses on neural graft ...
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January 1, 2004
Neurotrauma, neurosurgical intervention, and cerebrovascular disease all involve combinations of immediate or primary injury and delayed or secondary injury (see Chapter 4 for information on cellular treatments of stroke and hypoxia/ischemia). The primary ...
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January 1, 2004
Disorders of movement represent the frontier of understanding of brain function in that the basic mechanisms underlying normal (and abnormal) movement can be ascribed to individual brain structures, but the detailed functions of these structures and their ...
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January 1, 2004
Clinical trials are the key interfaces of basic science findings, product development, rationalization of existing therapies, and their translation into effective clinical therapy (see Chapter 1). Thus, all translational research depends upon clinical tria ...
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January 1, 2004
The concept of “translational” research is based on the effective rendering of research ideas into actual clinical practice - in other words “translating” the research finding into clinical usefulness.1,2 This concept has many different definitions, depend ...
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January 1, 2004
Delayed cerebral vasospasm (DCV) is the leading cause of morbidity and mortality in patients who have ruptured intracranial aneurysms and are admitted to tertiary care centers.1,2 Thick focal collections of blood visualized on a CT scan are highly predicti ...
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January 1, 2004
What is the process through which a medical student becomes a neurosurgeon? How do we teach the skills necessary for success? What role does a resident play in his or her own educational process? Before consideration of neurosurgical simulators, we should ...
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https://orcid.org/0000-0001-7118-0764