Dennis Alan Turner

Journal article Neurology · April 30, 2013 Featured Publication OBJECTIVE: In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally administering the gene ... Full text Link to item Cite

Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease.

Journal article Exp Neurol · January 2013 Featured Publication High frequency deep brain stimulation is an effective therapy for motor symptoms in Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular temporal patterns of stimulation in Parkinson's disease remains unclear. To deter ... Full text Link to item Cite

Exploiting metabolic differences in glioma therapy.

Journal article Curr Drug Discov Technol · December 2012 Featured Publication Brain function depends upon complex metabolic interactions amongst only a few different cell types, with astrocytes providing critical support for neurons. Astrocyte functions include buffering the extracellular space, providing substrates to neurons, inte ... Full text Link to item Cite

Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.

Journal article J Neurosci · June 20, 2012 Featured Publication Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utili ... Full text Link to item Cite

Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation.

Journal article J Neurophysiol · January 2012 Featured Publication Deep brain stimulation (DBS) provides dramatic tremor relief when delivered at high-stimulation frequencies (more than ∼100 Hz), but its mechanisms of action are not well-understood. Previous studies indicate that high-frequency stimulation is less effecti ... Full text Link to item Cite

Cellular Links between Neuronal Activity and Energy Homeostasis.

Journal article Front Pharmacol · 2012 Featured Publication Neuronal activity, astrocytic responses to this activity, and energy homeostasis are linked together during baseline, conscious conditions, and short-term rapid activation (as occurs with sensory or motor function). Nervous system energy homeostasis also v ... Full text Link to item Cite

Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation.

Journal article Neurobiol Dis · January 2012 Featured Publication The use of energy substrates, such as lactate and pyruvate, has been shown to improve synaptic function when administered during glucose deprivation. In the present study, we investigated whether prolonged incubation with monocarboxylate (pyruvate or lacta ... Full text Link to item Cite

Age-Induced Alterations in Hippocampal Function and Metabolism.

Journal article Aging Dis · June 2011 Featured Publication As the nervous system ages, a variety of changes occur in metabolism supporting glial and neuronal function, resulting in greater susceptibility to disease conditions. Changes with aging in the metabolic unit (i.e., neurons, glial cells and blood vessels) ... Link to item Cite

Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices.

Journal article J Cereb Blood Flow Metab · February 2011 Featured Publication Nicotinamide adenine dinucleotide (NADH) imaging can be used to monitor neuronal activation and ascertain mitochondrial dysfunction, for example during hypoxia. During neuronal stimulation in vitro, NADH normally becomes more oxidized, indicating enhanced ... Full text Link to item Cite

Analysis of the time course of the effect of subthalamic nucleus stimulation upon hand function in Parkinson's patients.

Journal article Stereotact Funct Neurosurg · 2011 Featured Publication BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) as treatment for Parkinson's disease has been in use for more than a decade, yet the immediate effect of stimulation upon movement parameters is not well characterized. OBJECTIVE: Th ... Full text Link to item Cite

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.

Journal article Lancet Neurol · December 2010 Featured Publication BACKGROUND: In an open-label phase 1 trial, gene delivery of the trophic factor neurturin via an adeno-associated type-2 vector (AAV2) was well tolerated and seemed to improve motor function in patients with advanced Parkinson's disease. We aimed to assess ... Full text Link to item Cite

Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity.

Journal article J Neurophysiol · August 2010 Featured Publication Deep brain stimulation (DBS) of the basal ganglia can alleviate the motor symptoms of Parkinson's disease although the therapeutic mechanisms are unclear. We hypothesize that DBS relieves symptoms by minimizing pathologically disordered neuronal activity i ... Full text Link to item Cite

NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia.

Journal article Neurobiol Aging · April 2008 Featured Publication Aging increases mitochondrial dysfunction and susceptibility to hypoxia. Previous reports have indicated an association between post-hypoxic hyperoxidation of intra-mitochondrial enzymes and delayed neuronal injury. Therefore we investigated the relationsh ... Full text Link to item Cite

The development of brain-machine interface neuroprosthetic devices.

Journal article Neurotherapeutics · January 2008 Featured Publication The development of brain-machine interface technology is a logical next step in the overall direction of neuroprosthetics. Many of the required technological advances that will be required for clinical translation of brain-machine interfaces are already un ... Full text Link to item Cite

Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices.

Journal article J Neurochem · December 2007 Featured Publication Synaptic train stimulation (10 Hz x 25 s) in hippocampal slices results in a biphasic response of NAD(P)H fluorescence indicating a transient oxidation followed by a prolonged reduction. The response is accompanied by a transient tissue PO(2) decrease indi ... Full text Link to item Cite

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease.

Journal article Ann Neurol · March 2006 Featured Publication OBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF) exerts potent trophic influence on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed to confirm initial clinical benefits observed in a small, open-label tria ... Full text Link to item Cite

National trends in surgical procedures for degenerative cervical spine disease: 1990-2000.

Journal article Neurosurgery · October 2005 Featured Publication OBJECTIVE: Degenerative cervical spine disease is one of the most common indications for spinal surgical intervention. The impact of the unprecedented changes in healthcare technology and delivery over the past decade is unknown. We examined this issue usi ... Link to item Cite

Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures.

Journal article Spine (Phila Pa 1976) · July 1, 2004 Featured Publication STUDY DESIGN: A 3-year prospective, cohort study. OBJECTIVES: To compare the incidence and risk factors of dysphagia after anterior cervical (AC), posterior cervical (PC), and posterior lumbar (PL) spine procedures. SUMMARY OF BACKGROUND DATA: Dysphagia is ... Full text Link to item Cite

Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface.

Journal article Neurosurgery · July 2004 Featured Publication OBJECTIVE: Patients with severe neurological injury, such as quadriplegics, might benefit greatly from a brain-machine interface that uses neuronal activity from motor centers to control a neuroprosthetic device. Here, we report an implementation of this s ... Link to item Cite

Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy.

Journal article Neurosurgery · March 2003 Featured Publication OBJECTIVE: Hippocampal lesions and epilepsy may be potential clinical targets for neural grafting. We hypothesized that neural grafting could be a restorative therapy either acutely, adding unformed neural elements, or chronically, treating postlesioning e ... Full text Link to item Cite

Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area.

Journal article Spine (Phila Pa 1976) · May 15, 2002 Featured Publication STUDY DESIGN: Magnetic resonance image grading of lumbar spinal stenosis severity was analyzed retrospectively using a common clinical format. OBJECTIVE: To assess the interobserver and intraobserver reliability of magnetic resonance image used to grade pa ... Full text Link to item Cite

Surgical correction of lumbar kyphotic deformity: posterior reduction "eggshell" osteotomy.

Journal article J Neurosurg · January 2000 Featured Publication OBJECT: Progressive kyphotic deformity of the lumbar or thoracolumbar spine may lead to back pain, cosmetic deformity, and risk of neurological compromise. The authors describe a series of patients in whom they performed a single-stage, posterior reduction ... Full text Link to item Cite

In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor.

Journal article J Neurobiol · June 15, 1998 Featured Publication Neural stem cells proliferate in vitro and form neurospheres in the presence of epidermal growth factor (EGF), and are capable of differentiating into both neurons and glia when exposed to a substrate. We hypothesize that specific neurotrophic factors indu ... Full text Link to item Cite