Overview
Devjanee (Devi) Swain Lenz, PhD, is the Director of the Duke Sequencing and Genomics Technologies Core Facility (SGT) and has over 15 years of experimental and computational experience in genomics research. She earned her PhD in Molecular Genetics and Genomics at Washington University in St. Louis and completed her postdoctoral research at Duke University. Her research interests focus on understanding how cis-regulatory variation contributes to phenotypic differences between and within species. She has also held multiple leadership roles for nonprofit organizations whose emphasis is on increasing and maintaining diversity, equity, and inclusion in STEM-related fields.
If you are interested in working with the SGT, you can find more information on our website or schedule a consultation.
Current Appointments & Affiliations
Recent Publications
Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis within Tuberculous Granulomas.
Preprint · April 27, 2025 Full text Link to item CiteType I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages.
Journal Article J Biol Chem · November 2024 The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn's disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased production of a number of inflammatory chemokines and cytoki ... Full text Link to item CiteGenetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis.
Journal Article Rheumatology (Oxford) · September 1, 2024 OBJECTIVE: To better understand the pathogenesis of juvenile dermatomyositis (JDM), we examined the effect of the cytokines type I interferons (IFN I) and JAK inhibitor drugs (JAKi) on gene expression in bioengineered pediatric skeletal muscle. METHODS: My ... Full text Link to item CiteRecent Grants
Developing strategies to identify candidate individuals for early genetic therapies
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Applied Physiology of CNS Oxygen Toxicity: Mechanisms in Humans
ResearchStatistician · Awarded by Office of Naval Research · 2023 - 2026EPA Metagenomics - Molina
ResearchPrincipal Investigator · Awarded by Environmental Protection Agency · 2023 - 2024View All Grants