Scholars@Duke
Devon James Godfrey

Devon James Godfrey

Associate Professor of Radiation Oncology
Radiation Oncology
devon.godfrey@duke.edu
Box 3295 Med Ctr, DUMC, Durham, NC 27710
Radiation Oncology, Physics, Box 3295, DUMC, Durham, NC 27710

Scholarly Works - Journal articles

Outcomes of 5- Versus 10-Fraction Radiation Therapy for Hepatocellular Carcinoma at a Veteran Affairs Hospital.

Journal article Int J Radiat Oncol Biol Phys · April 30, 2026 PURPOSE: To compare outcomes, liver toxicity, and survival between patients with hepatocellular carcinoma treated with hypofractionaed image-guided radiation therapy (HIGRT) delivered in 5 versus 10 fractions within a Veterans Affairs (VA) population. METH ... Full text Link to item Cite

Toxicity of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Journal article Cancers (Basel) · February 19, 2026 BACKGROUND/OBJECTIVES: Hypofractionated ablative radiation is an increasingly popular option for patients with hepatocellular carcinoma (HCC). However, concern remains about the risk for radiation-induced liver toxicity in patients with decompensated liver ... Full text Link to item Cite

A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.

Journal article Sci Data · May 15, 2024 Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and l ... Full text Link to item Cite

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery.

Journal article J Neurooncol · March 2024 PURPOSE: During stereotactic radiosurgery (SRS) planning for brain metastases (BM), brain MRIs are reviewed to select appropriate targets based on radiographic characteristics. Some BM are difficult to detect and/or definitively identify and may go untreat ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2023 PURPOSE: We sought to develop a computer-aided detection (CAD) system that optimally augments human performance, excelling especially at identifying small inconspicuous brain metastases (BMs), by training a convolutional neural network on a unique magnetic ... Full text Link to item Cite

Impact of Race on Outcomes of High-Risk Patients With Prostate Cancer Treated With Moderately Hypofractionated Radiotherapy in an Equal Access Setting.

Journal article Fed Pract · August 2022 BACKGROUND: Moderately hypofractionated radiotherapy (MHRT) is an accepted treatment for localized prostate cancer; however, limited MHRT data address high-risk prostate cancer (HRPC) and/or African American patients. We report clinical outcomes and toxici ... Full text Link to item Cite

Effect of Large Prostate Volume on Efficacy and Toxicity of Moderately Hypofractionated Radiation Therapy in Patients With Prostate Cancer.

Journal article Adv Radiat Oncol · 2022 PURPOSE: To evaluate the effect of prostate volume on outcomes after moderately hypofractionated radiation therapy (mHFRT) for prostate cancer. METHODS AND MATERIALS: Prostate cancer patients treated with mHFRT at a Veteran's Affairs Medical Center from Au ... Full text Link to item Cite

A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity Modulated Radiation Therapy in Early-Stage Prostate Cancer Patients.

Journal article Int J Radiat Oncol Biol Phys · July 15, 2021 PURPOSE: Data comparing moderately hypofractionated intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) are lacking. We aim to compare late toxicity profiles of patients with early-stage prostate cancer treated with moderately hypofr ... Full text Link to item Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal article Pract Radiat Oncol · 2019 PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. METHOD ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

Triphasic contrast enhanced CT simulation with bolus tracking for pancreas SBRT target delineation.

Journal article Pract Radiat Oncol · 2017 PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) ... Full text Link to item Cite

The effect of averaging adjacent planes for artifact reduction in matrix inversion tomosynthesis.

Journal article Med Phys · February 2013 PURPOSE: Matrix inversion tomosynthesis (MITS) uses linear systems theory and knowledge of the imaging geometry to remove tomographic blur that is present in conventional backprojection tomosynthesis reconstructions, leaving in-plane detail rendered clearl ... Full text Link to item Cite

SU-E-J-16: Prostate Bed Motion during Post-Prostatectomy Radiotherapy.

Journal article Med Phys · June 2012 PURPOSE: To report the inter-fractional prostate bed motion (PBM) during post-prostatectomy radiotherapy using cone-beam CT (CBCT). The correlations between PBM, anterior rectal wall and posterior bladder wall shifts were also investigated. METHODS: Sevent ... Full text Link to item Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2011 PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

Stochastic noise characteristics in matrix inversion tomosynthesis (MITS).

Journal article Med Phys · May 2009 Matrix inversion tomosynthesis (MITS) uses known imaging geometry and linear systems theory to deterministically separate in-plane detail from residual tomographic blur in a set of conventional tomosynthesis ("shift-and-add") planes. A previous investigati ... Full text Link to item Cite

Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Journal article Int J Radiat Oncol Biol Phys · March 1, 2009 PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). ... Full text Link to item Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

On-board four-dimensional digital tomosynthesis: first experimental results.

Journal article Med Phys · August 2008 The purpose of this study is to propose four-dimensional digital tomosynthesis (4D-DTS) for on-board analysis of motion information in three dimensions. Images of a dynamic motion phantom were reconstructed using acquisition scan angles ranging from 20 deg ... Full text Link to item Cite

A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map.

Journal article Med Phys · July 2008 We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new pr ... Full text Link to item Cite

Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial.

Journal article Med Phys · June 2008 The authors report interim clinical results from an ongoing NIH-sponsored trial to evaluate digital chest tomosynthesis for improving detectability of small lung nodules. Twenty-one patients undergoing computed tomography (CT) to follow up lung nodules wer ... Full text Link to item Cite

Digital tomosynthesis of the chest.

Journal article J Thorac Imaging · May 2008 Digital tomosynthesis is a technique that generates an arbitrary number of section images of a patient from a single pass of the x-ray tube. It is under investigation for application to a number of clinical detection tasks, and has recently been implemente ... Full text Link to item Cite

Fast reconstruction of digital tomosynthesis using on-board images.

Journal article Med Phys · May 2008 Digital tomosynthesis (DTS) is a method to reconstruct pseudo three-dimensional (3D) volume images from two-dimensional x-ray projections acquired over limited scan angles. Compared with cone-beam computed tomography, which is frequently used for 3D image ... Full text Link to item Cite

Automatic registration between reference and on-board digital tomosynthesis images for positioning verification.

Journal article Med Phys · February 2008 The authors developed a hybrid multiresolution rigid-body registration technique to automatically register reference digital tomosynthesis (DTS) images with on-board DTS images to guide patient positioning in radiation therapy. This hybrid registration tec ... Full text Link to item Cite

An implantable MOSFET dosimeter for the measurement of radiation dose in tissue during cancer therapy

Journal article IEEE Sensors Journal · January 1, 2008 This paper describes the functionality, radiation characteristics, and clinical implementation of an implantable MOSFET radiation detector (dosimeter). The dosimeter is powered by radio frequency telemetry eliminating the need for a power source inside the ... Full text Cite

Initial application of digital tomosynthesis to improve brachytherapy treatment planning

Journal article Progress in Biomedical Optics and Imaging Proceedings of SPIE · October 15, 2007 We present preliminary investigations that examine the feasibility of incorporating volumetric images generated using digital tomosynthesis into brachytherapy treatment planning. The Integrated Brachytherapy Unit (IBU) at our facility consists of an L-arm, ... Full text Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal article Int J Radiat Oncol Biol Phys · October 1, 2007 PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Accelerating reconstruction of reference digital tomosynthesis using graphics hardware.

Journal article Med Phys · October 2007 The successful implementation of digital tomosynthesis (DTS) for on-board image guided radiation therapy (IGRT) requires fast DTS image reconstruction. Both target and reference DTS image sets are required to support an image registration application for I ... Full text Link to item Cite

Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

Journal article Med Phys · August 2007 Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-ang ... Full text Link to item Cite

Digital tomosynthesis with an on-board kilovoltage imaging device.

Journal article Int J Radiat Oncol Biol Phys · May 1, 2006 PURPOSE: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT). METHODS AND MA ... Full text Link to item Cite

Optimization of the matrix inversion tomosynthesis (MITS) impulse response and modulation transfer function characteristics for chest imaging.

Journal article Med Phys · March 2006 Matrix inversion tomosynthesis (MITS) uses linear systems theory, along with a priori knowledge of the imaging geometry, to deterministically distinguish between true structure and overlying tomographic blur in a set of conventional tomosynthesis planes. I ... Full text Link to item Cite

Initial application of digital tomosynthesis with on-board imaging in radiation oncology

Journal article Progress in Biomedical Optics and Imaging Proceedings of SPIE · August 25, 2005 We present preliminary investigations that examine the feasibility of incorporating digital tomosynthesis into radiation oncology practice with the use of kilovoltage on-board imagers (OBI). Modern radiation oncology linear accelerators now include hardwar ... Full text Cite

MO‐D‐I‐6B‐04: Matrix Inversion Tomosynthesis (MITS) Imaging of the Chest

Journal article Medical Physics · January 1, 2005 Tomosynthesis is a method for reconstructing 3‐dimensional (3‐D) image data from a series of x‐ray projection radiographs, acquired with limited motion of the x‐ray source (typically no more than 40 degrees). Digital tomosynthesis (DTS) is implemented with ... Full text Cite

Digital x-ray tomosynthesis: current state of the art and clinical potential.

Journal article Phys Med Biol · October 7, 2003 Digital x-ray tomosynthesis is a technique for producing slice images using conventional x-ray systems. It is a refinement of conventional geometric tomography, which has been known since the 1930s. In conventional geometric tomography, the x-ray tube and ... Full text Link to item Cite

Practical strategies for the clinical implementation of matrix inversion tomosynthesis (MITS)

Journal article Proceedings of SPIE the International Society for Optical Engineering · September 15, 2003 Digital tomosynthesis is a method that enables the retroactive reconstruction of arbitrary tomographic planes in an object from a finite series of digital projection radiographs, acquired with limited angle tube movement. Conventional tomosynthesis suffers ... Full text Cite

Optimization of matrix inverse tomosynthesis

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 2001 Digital tomosynthesis is a method for reconstructing arbitrary planes in an object from a series of projection radiographs, acquired with limited angle tube movement. Conventional 'shift and add' tomosynthesis suffers from the presence of blurring artifact ... Full text Cite

Applications of matrix inverse tomosynthesis

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 2000 The improved image quality and characteristics of new flat-panel x-ray detectors have renewed interest in advanced algorithms such as tomosynthesis. Digital tomosynthesis is a method of acquiring and reconstructing a three-dimensional data set with limited ... Cite

Frequency-domain technique for optical property measurements in moderately scattering media.

Journal article Opt Lett · January 1, 2000 We demonstrate a reflection geometry frequency-domain technique that is suitable for measurement of the optical properties of a medium with moderate scatter and absorption (mu(s) and mu(a) ~ 1 m(-1)). Variations in absorption and scatter produce opposing t ... Full text Link to item Cite

Application of frequency domain techniques to samples with moderate scatter

Journal article Proceedings of SPIE the International Society for Optical Engineering · January 1, 1999 We show that the optical properties of a sample with moderate scatter can be obtained by performing frequency domain measurements in a reflection geometry. In experiments and Monte Carlo simulations we show that absorption and scatter produce opposing tren ... Cite