Scholars@Duke
Dewey G. McCafferty

Dewey G. McCafferty

Professor of Chemistry
Chemistry
dewey.mccafferty@duke.edu
Box 90346, B120 LSRC Bldg, Dept. Chemistry, Durham, NC 27708-0346
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346

Featured Works

Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin*.

Journal article Chembiochem : a European journal of chemical biology · January 2021 Featured Publication Ramoplanins and enduracidins are peptidoglycan lipid intermediate II-binding lipodepsipeptides with broad-spectrum activity against methicillin- and vancomycin-resistant Gram-positive pathogens. Targeted genome mining using probes from conserved sequences ... Full text Cite

Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli.

Journal article Protein expression and purification · September 2020 Featured Publication Nedd4 is an E3 ubiquitin ligase that has received increased attention due to its role in the maintenance of proteostasis and in cellular stress responses. Investigation of Nedd4 enzymology has revealed a complex enzymatic mechanism that involves intermolec ... Full text Cite

Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF.

Journal article Biochemistry · August 20, 2019 Featured Publication CPAF (chlamydial protease-like activity factor) is a Chlamydia trachomatis protease that is translocated into the host cytosol during infection. CPAF activity results in dampened host inflammation signaling, cytoskeletal remodeling, and suppressed neutroph ... Full text Link to item Cite