David Noble Howell

Journal article Am J Physiol Renal Physiol · August 2008 Featured Work Activation of the renin-angiotensin system contributes to the progression of chronic kidney disease. Based on the known cellular effects of ANG II to promote inflammation, we posited that stimulation of lymphocyte responses by ANG II might contribute to th ... Full text Link to item Cite

Malignancy after solid organ transplantation: an overview.

Journal article Oncologist · July 2008 Featured Work With improving survival following solid organ transplantation, clinicians must be aware of post-transplant complications. One increasingly frequent complication is the development of malignancy after transplantation. The most common malignancies encountere ... Full text Link to item Cite

Postinfectious glomerulonephritis in renal allograft recipients.

Journal article Transplantation · November 15, 2006 Featured Work Postinfectious glomerulonephritis (PIGN) is a rare etiology of de novo glomerulonephritis following kidney transplantation. To date, there have only been eight cases reported in the literature. We report an additional three patients transplanted at our ins ... Full text Link to item Cite

Cytomegalovirus infection presenting as bronchial polyps in lung transplant recipients.

Journal article J Heart Lung Transplant · December 2005 Featured Work BACKGROUND: Cytomegalovirus (CMV) is the most important opportunistic pathogen in lung transplant recipients and is associated with direct and indirect morbidity. Infection or disease with CMV is often diagnosed through detection of the virus in the blood, ... Full text Link to item Cite

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.

Journal article Science · June 17, 2005 Featured Work Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene o ... Full text Link to item Cite

A man with chest pain and glomerulonephritis.

Journal article Lancet · June 11, 2005 Featured Work Full text Link to item Cite

Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient.

Journal article J Heart Lung Transplant · May 2005 Featured Work Intravenous injection of drugs that contain insoluble foreign material can lead to pulmonary embolization of the material and can have devastating results, including pulmonary hypertension and death. Most cases are detected after the onset of extensive, ir ... Full text Link to item Cite

Organized deposits in the kidney and look-alikes.

Journal article Ultrastruct Pathol · 2003 Featured Work Organized or structured deposits are encountered during electron microscopic examination of kidney tissue in a wide variety of primary renal and multisystemic disorders. They are most commonly seen in the renal glomerulus, though extraglomerular sites are ... Link to item Cite

The pathology of liver-localized post-transplant lymphoproliferative disease: a report of three cases and a review of the literature.

Journal article Am J Surg Pathol · May 2000 Featured Work Post-transplantation lymphoproliferative disease (PTLD) is a complication of solid organ transplantation that is typically of B-cell origin and associated with Epstein-Barr virus (EBV). In patients receiving orthotopic liver transplantation (OLT) and treat ... Full text Link to item Cite

Glomerulopathies with fibrillary deposits.

Journal article Ultrastruct Pathol · 2000 Featured Work Renal diseases involving glomerular deposits of fibrillary material are an important diagnostic challenge for the ultrastructural pathologist. Two primary disorders of this type, termed "fibrillary glomerulonephritis" (characterized by fibrils measuring ap ... Full text Link to item Cite

Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients.

Journal article Transplantation · November 15, 1999 Featured Work BACKGROUND: Interstitial nephritis caused by BK polyomavirus is a recognized complication of renal transplantation. A study of renal transplant recipients at Duke University Medical Center was undertaken to evaluate diagnostic modalities and assess clinica ... Full text Link to item Cite

Spectrum of disease in familial focal and segmental glomerulosclerosis.

Journal article Kidney Int · November 1999 Featured Work BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is the underlying pathologic entity in 5% of adults and 20% of children with end-stage renal disease (ESRD). FSGS is generally considered to be sporadic in origin. METHODS: Recently, we identified 60 fa ... Full text Link to item Cite

Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity.

Journal article Genomics · June 1, 1999 Featured Work Focal segmental glomerulosclerosis (FSGS) is a pathological entity characterized by proteinuria, nephrotic syndrome, and the progressive loss of renal function. It is a common cause of end-stage renal disease (ESRD). Recently, familial forms of FSGS have b ... Full text Link to item Cite

Focal segmental glomerulosclerosis: a need for caution in live-related renal transplantation.

Journal article Am J Kidney Dis · May 1999 Featured Work Focal segmental glomerulosclerosis (FSGS) has increasingly been recognized to occur in a familial pattern. We have observed the development of biopsy-confirmed FSGS and subsequent end-stage renal disease (ESRD) in one live related kidney donor and ESRD wit ... Full text Link to item Cite

Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis.

Journal article Kidney Int · April 1999 Featured Work BACKGROUND: Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred ... Full text Link to item Cite

Special techniques in diagnostic electron microscopy.

Journal article Hum Pathol · December 1998 Featured Work The power of electron microscopy as a diagnostic tool can be amplified considerably by the application of ancillary preparative and analytic methods. Subcellular chemistry and structure can be examined by various forms of microprobe analysis and by special ... Full text Link to item Cite