Scholars@Duke
Donald Benjamin Sanders

Donald Benjamin Sanders

Professor Emeritus of Neurology
Neurology, Neuromuscular Disease
donald.sanders@duke.edu
Duke Box 3403, Durham, NC 27710
1255 Hosp South, Durham, NC 27710

Featured Works

The MG-QOL15 for following the health-related quality of life of patients with myasthenia gravis.

Journal article Muscle Nerve · January 2011 Featured Publication The MG-QOL15 is helpful in informing the clinician about the patient's perception of the extent of and dissatisfaction with myasthenia gravis (MG)-related dysfunction. The aims of this study were to determine the usefulness of the MG-QOL15 for following in ... Full text Link to item Cite

Immunosuppressive therapies in myasthenia gravis.

Journal article Autoimmunity · August 2010 Featured Publication Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients ... Full text Link to item Cite

The MG Composite: A valid and reliable outcome measure for myasthenia gravis.

Journal article Neurology · May 4, 2010 Featured Publication OBJECTIVE: To study the concurrent and construct validity and test-retest reliability in the practice setting of an outcome measure for myasthenia gravis (MG). METHODS: Eleven centers participated in the validation study of the Myasthenia Gravis Composite ... Full text Link to item Cite

Mycophenolate mofetil in AChR-antibody-positive myasthenia gravis: outcomes in 102 patients.

Journal article Muscle Nerve · May 2010 Featured Publication Two recent randomized, controlled trials failed to demonstrate a benefit of mycophenolate mofetil (MMF) over prednisone in the treatment of myasthenia gravis (MG). We reviewed our experience with MMF in MG to determine whether these trials may have been un ... Full text Link to item Cite

Jitter recordings with concentric needle electrodes.

Journal article Muscle Nerve · September 2009 Featured Publication Neuromuscular jitter is generally recorded with a single fiber (SF) electromyography (EMG) electrode. Due to concern about using reusable needle electrodes, an acceptable alternative for the SF electrode has been sought. This is a review of the issues invo ... Full text Link to item Cite

Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.

Journal article Lancet Neurol · May 2009 Featured Publication Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction in which patients experience fluctuating skeletal muscle weakness that often affects selected muscle groups preferentially. The target of the autoimmune attack in most ... Full text Link to item Cite

An international, phase III, randomized trial of mycophenolate mofetil in myasthenia gravis.

Journal article Neurology · August 5, 2008 Featured Publication BACKGROUND: This prospective, randomized, double-blind, placebo-controlled, phase III trial assessed the efficacy, safety, and tolerability of mycophenolate mofetil (MMF) as a steroid-sparing agent in patients with myasthenia gravis (MG). METHODS: Patients ... Full text Link to item Cite

Lessons from two trials of mycophenolate mofetil in myasthenia gravis.

Journal article Ann N Y Acad Sci · 2008 Featured Publication Two randomized controlled trials of mycophenolate mofetil (MMF) in the treatment of myasthenia gravis (MG) were recently completed. Although neither study demonstrated efficacy of MMF in the population of patients studied, there are valuable lessons in the ... Full text Link to item Cite

The Lambert-Eaton myasthenic syndrome.

Journal article Handb Clin Neurol · 2008 Featured Publication Full text Link to item Cite

Clinical features of myasthenia gravis.

Journal article Handb Clin Neurol · 2008 Featured Publication Full text Link to item Cite

MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns.

Journal article Clin Neurophysiol · September 2005 Featured Publication OBJECTIVE: To examine the clinical manifestations and patterns of electromyographic abnormalities in MuSK-Ab positive myasthenia gravis. METHODS: The clinical evaluations and electrodiagnostic testing results of 20 MuSK-Ab positive myasthenia gravis patien ... Full text Link to item Cite

Advances in the diagnosis of neuromuscular junction disorders.

Journal article Am J Phys Med Rehabil · August 2005 Featured Publication Disorders of the neuromuscular junction have a wide range of clinical presentations, which frequently poses a diagnostic challenge to evaluating clinicians. This article describes the tests used in the diagnosis of diseases of the neuromuscular junction, r ... Full text Link to item Cite

Electrophysiologic tests of neuromuscular transmission.

Journal article Suppl Clin Neurophysiol · 2004 Featured Publication Full text Link to item Cite

Clinical impact of single-fiber electromyography.

Journal article Muscle Nerve Suppl · 2002 Featured Publication The major clinical impact of single-fiber electromyography has been from its role in confirming, or excluding, the diagnosis of myasthenia gravis (MG). Jitter measurements also have a clinical role in demonstrating changes in disease severity in patients w ... Full text Link to item Cite

Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment.

Journal article Neurology · June 13, 2000 Featured Publication The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor a ... Full text Link to item Cite

A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

Journal article Neurology · February 8, 2000 Featured Publication OBJECTIVES: The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term ... Full text Link to item Cite

Quantitative motor unit potential analysis.

Journal article J Clin Neurophysiol · September 1996 Featured Publication A review of quantitative methods for electromyography is given. Background information about motor unit anatomy, physiology, and pathology is provided to explain some of the presented electrophysiological phenomena. Different aspects of quantitation, such ... Full text Link to item Cite

Analysis of the electromyographic interference pattern.

Journal article J Clin Neurophysiol · September 1996 Featured Publication The electromyographic interference pattern (EMG-IP) contains information about the number, firing rate, and recruitment characteristics of motor units, and information regarding the waveforms of the recruited motor units. Muscle and nerve diseases produce ... Full text Link to item Cite

AAEM minimonograph #25: single-fiber electromyography.

Journal article Muscle Nerve · September 1996 Featured Publication Single-fiber electromyography (SFEMG) is a selective recording technique in which a needle electrode with a small recording surface in the side is used to identify action potentials from individual muscle fibers. The SFEMG parameters of greatest clinical u ... Full text Link to item Cite

Race, sex, and puberty influence onset, severity, and outcome in juvenile myasthenia gravis.

Journal article Neurology · July 1994 Featured Publication We assessed the influence of race, sex, and puberty upon clinical features and outcome in 115 patients with autoimmune juvenile myasthenia gravis (JMG). These demographic variables influenced not only disease incidence but also disease severity, response t ... Full text Link to item Cite

Ephaptic transmission in hemifacial spasm: a single-fiber EMG study.

Journal article Muscle Nerve · August 1989 Featured Publication In two patients with hemifacial spasm (HFS), single-fiber EMG recordings in facial muscles demonstrated low jitter in the late responses produced by stimulation of peripheral branches to other facial muscles. Surgical decompression of the facial nerve in o ... Full text Link to item Cite

Management of facial spasm with Clostridium botulinum toxin.

Journal article Arch Otolaryngol Head Neck Surg · July 1989 Featured Publication Full text Link to item Cite