Dong Yan

Journal article Neuron · January 3, 2018 Featured Work Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. Here, we reveal an unexpected ... Full text Open Access Link to item Cite

Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegans.

Journal article PLoS Genet · June 2017 Featured Work Neural circuits are dynamic, with activity-dependent changes in synapse density and connectivity peaking during different phases of animal development. In C. elegans, young larvae form mature motor circuits through a dramatic switch in GABAergic neuron con ... Full text Link to item Cite

Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans.

Journal article Elife · October 21, 2016 Featured Work Axon specification is a critical step in neuronal development, and the function of glial cells in this process is not fully understood. Here, we show that C. elegans GLR glial cells regulate axon specification of their nearby GABAergic RME neurons through ... Full text Link to item Cite

Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.

Journal article PLoS Genet · March 2016 Featured Work Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. ... Full text Link to item Cite

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.

Journal article Cell Rep · June 23, 2015 Featured Work Synapse elimination occurs in development, plasticity, and disease. Although the importance of synapse elimination has been documented in many studies, the molecular mechanisms underlying this process are unclear. Here, using the development of C. elegans ... Full text Open Access Link to item Cite

Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.

Journal article Neuron · November 8, 2012 Featured Work MAPKKK dual leucine zipper-bearing kinases (DLKs) are regulators of synaptic development and axon regeneration. The mechanisms underlying their activation are not fully understood. Here, we show that C. elegans DLK-1 is activated by a Ca(2+)-dependent swit ... Full text Open Access Link to item Cite