Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Technical Consultant, Medicine, Harvard University 2002 - 2004
  • Technical Supervisor & Staff Specialist, Clinical Immunology Laboratory, Harvard University 1997 - 2002
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  Previous Appointments & Affiliations

  • Associate Professor in Pathology, Pathology, Clinical Science Departments 2006 - 2020
  • Assistant Clinical Professor in Pathology, Pathology, Clinical Science Departments 2004 - 2006
  • Instructor, Temporary in Pathology, Pathology, Clinical Science Departments 2004
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  Academic Positions Outside Duke

  • Associate Laboratory Director, Immunogenetics and Transplantation Laboratory, University of California San Francisco, School of Medicine. 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Truby, Lauren K., Lydia Coulter Kwee, Richa Agarwal, Elizabeth Grass, Adam D. DeVore, Chetan B. Patel, Dongfeng Chen, et al. “Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.” J Heart Lung Transplant 40, no. 12 (December 2021): 1589–98. https://doi.org/10.1016/j.healun.2021.07.024.
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    • Barac, Yaron D., Mike S. Mulvihill, Oliver Jawitz, Jacob Klapper, John Haney, Mani Daneshmand, Basil Nasir, Dongfeng Chen, Carmelo A. Milano, and Matthew G. Hartwig. “Increased Calculated Panel Reactive Antigen Is Associated With Increased Waitlist Time and Mortality in Lung Transplantation.” Ann Thorac Surg 110, no. 2 (August 2020): 414–23. https://doi.org/10.1016/j.athoracsur.2020.02.061.
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    • Parsons, Ronald F., Arslan Zahid, Shalini Bumb, Hannah Decker, Harold C. Sullivan, Frances Eun-Hyung Lee, Idelberto Raul Badell, et al. “The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients.” Am J Transplant 20, no. 2 (February 2020): 573–81. https://doi.org/10.1111/ajt.15585.
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    • Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.
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    • Freischlag, Kyle W., Vivian Chen, Shashi K. Nagaraj, Annabelle N. Chua, Dongfeng Chen, Delbert R. Wigfall, John W. Foreman, Rasheed Gbadegesin, Deepak Vikraman, and Eileen T. Chambers. “Psychosocial Assessment of Candidates for Transplantation (PACT) Score Identifies High Risk Patients in Pediatric Renal Transplantation.” Front Pediatr 7 (2019): 102. https://doi.org/10.3389/fped.2019.00102.
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    • Cendales, Linda C., David S. Ruch, Adela R. Cardones, Guy Potter, Joshua Dooley, Daniel Dore, Jonah Orr, et al. “De novo belatacept in clinical vascularized composite allotransplantation.” Am J Transplant 18, no. 7 (July 2018): 1804–9. https://doi.org/10.1111/ajt.14910.
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    • Abbes, Sarah, Ara Metjian, Alice Gray, Tereza Martinu, Laurie Snyder, Dong-Feng Chen, Matthew Ellis, Gowthami M. Arepally, and Oluwatoyosi Onwuemene. “Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.” Ther Apher Dial 21, no. 5 (October 2017): 441–50. https://doi.org/10.1111/1744-9987.12570.
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    • Snyder, L. D., A. L. Gray, J. M. Reynolds, G. M. Arepally, A. Bedoya, M. G. Hartwig, R. D. Davis, et al. “Antibody desensitization therapy in highly sensitized lung transplant candidates.” Am J Transplant 14, no. 4 (April 2014): 849–56. https://doi.org/10.1111/ajt.12636.
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    • Snyder, Laurie D., Ziwei Wang, Dong-Feng Chen, Nancy L. Reinsmoen, C Ashley Finlen-Copeland, W Austin Davis, David W. Zaas, and Scott M. Palmer. “Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.” Chest 144, no. 1 (July 2013): 226–33. https://doi.org/10.1378/chest.12-0587.
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    • Chen, D. -. F., V. K. Prasad, G. Broadwater, N. L. Reinsmoen, A. DeOliveira, A. Clark, K. M. Sullivan, et al. “Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors.” Bone Marrow Transplant 47, no. 6 (June 2012): 817–23. https://doi.org/10.1038/bmt.2011.181.
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    • Martinu, Tereza, Elizabeth N. Pavlisko, Dong-Feng Chen, and Scott M. Palmer. “Acute allograft rejection: cellular and humoral processes.” Clin Chest Med 32, no. 2 (June 2011): 295–310. https://doi.org/10.1016/j.ccm.2011.02.008.
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    • Chinn, Ivan K., John A. Olson, Michael A. Skinner, Elizabeth A. McCarthy, Stephanie E. Gupton, Dong-Feng Chen, Francisco A. Bonilla, et al. “Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.” J Allergy Clin Immunol 126, no. 4 (October 2010): 814-820.e8. https://doi.org/10.1016/j.jaci.2010.07.016.
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    • Rizzieri, David A., Robert Storms, Dong-Feng Chen, Gwynn Long, Yiping Yang, Daniel A. Nikcevich, Cristina Gasparetto, et al. “Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation.” Biol Blood Marrow Transplant 16, no. 8 (August 2010): 1107–14. https://doi.org/10.1016/j.bbmt.2010.02.018.
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    • Snyder, L. D., T. Dick, W. A. Davis, D. Chen, B. Reams, S. M. Palmer, and D. W. Zaas. “Rituximab For The Treatment Of Humoral Rejection After Human Lung Transplant.” American Journal of Respiratory and Critical Care Medicine 181 (January 1, 2010).
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    • Martinu, Tereza, Dong-Feng Chen, and Scott M. Palmer. “Acute rejection and humoral sensitization in lung transplant recipients.” Proc Am Thorac Soc 6, no. 1 (January 15, 2009): 54–65. https://doi.org/10.1513/pats.200808-080GO.
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    • Keller, M. D., D. F. Chen, S. A. Condron, N. Liu, N. L. Reinsmoen, and R. H. Buckley. “The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID).” Journal of Clinical Immunology 27, no. 6 (November 12, 2007): 659–659. https://doi.org/10.1007/s10875-007-9116-9.
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    • Palmer, Kricia, Todd D. Green, Joseph L. Roberts, Elisa Sajaroff, Myriah Cooney, Roberta Parrott, Dong-Feng Chen, Nancy L. Reinsmoen, and Rebecca H. Buckley. “Unusual clinical and immunologic manifestations of transplacentally acquired maternal T cells in severe combined immunodeficiency.” J Allergy Clin Immunol 120, no. 2 (August 2007): 423–28. https://doi.org/10.1016/j.jaci.2007.02.047.
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    • Keller, M. D., D. F. Chen, S. A. Condron, N. Liu, N. L. Reinsmoen, and R. H. Buckley. “The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID).” J Clin Immunol 27, no. 1 (January 2007): 109–16. https://doi.org/10.1007/s10875-006-9058-7.
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  • Other Articles

    • Bray, R. A., P. Brannon, C. Breitenbach, C. Bryan, D. -. F. Chen, J. Lai, T. McRacken, et al. “The new OPTN kidney allocation policy: potential for inequitable access among highly sensitized patients.” Am J Transplant, January 2015. https://doi.org/10.1111/ajt.13061.
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  • Conference Papers

    • Halpin, Anne M., Robert A. Bray, Chris W. Cairo, Patricia M. Campbell, Dongfeng Chen, Esme Dijke, Tess Ellis, et al. “ABO ANTIBODY DETECTION: COMPARING APPLES TO APPLES IN A MULTI-SITE LUMINEX TOOL EVALUATION.” In Human Immunology, 81:36–37, 2020.
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    • Tian, Runying, Ashely Drabik, Wendy Hashew, Annette Jackson, and Dongfeng Chen. “THE NEED TO "PULL OUT ALL THE STOPS" FOR A KIDNEY TRANSPLANT.” In Human Immunology, 81:57–57, 2020.
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    • Deoliveira, Angelica, Ping Rao, Runying Tian, Candace M. Young, Wendy E. Hanshew, and Dongfeng Chen. “P020 Identification of a new C*06 null allele by SBT typing in an arabic family.” In Human Immunology, 79:74–74. Elsevier BV, 2018. https://doi.org/10.1016/j.humimm.2018.07.078.
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    • Tian, Runying, Yan Li, Candy Young, Hua Zhu, Wendy Hanshew, Ping Rao, and Dongfeng Chen. “P153 Could pbls provide with enough b cells for a successful flow crossmatch?” In Human Immunology, 79:176–176. Elsevier BV, 2018. https://doi.org/10.1016/j.humimm.2018.07.210.
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    • Rao, Ping, Angelica de Oliveira, Adella R. Clark, Wendy E. Hanshew, Runying Tian, and Dongfeng Chen. “P135 New frequent HLA-DPB1/DPA1 haplotypes in low resolution typing.” In Human Immunology, 78:153–153. Elsevier BV, 2017. https://doi.org/10.1016/j.humimm.2017.06.195.
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    • DeOliveira, Angelica, Jennifer Deitz, Candace Young, Michelle McLaughlin, Wendy Hanshew, and Dongfeng Chen. “The sooner the better: Our laboratory experience with chorionic villus sampling (CVS) HLA typing prior to HSCT.” In Human Immunology, 76:110–110. Elsevier BV, 2015. https://doi.org/10.1016/j.humimm.2015.07.157.
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    • Wang, H., L. Wan, Q. Yang, W. E. Hanshew, R. D. Davis, and D. Chen. “Impact of Repeated Mismatch Human Leukocyte Antigen on the Outcome of Lung Retransplantation.” In The Journal of Heart and Lung Transplantation, 34:S47–S47. Elsevier BV, 2015. https://doi.org/10.1016/j.healun.2015.01.114.
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    • Balgansuren, Gansuvd, Karine Lopes, Adella Clark, Linda Peel, Candace Young, Angelica Deoliveira, Wendy Wegner, and Dongfeng Chen. “P101.” In Human Immunology, 75:121–121. Elsevier BV, 2014. https://doi.org/10.1016/j.humimm.2014.08.163.
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    • Balgansuren, Gansuvd, Karine Lopes, and Dongfeng Chen. “P116.” In Human Immunology, 75:131–131. Elsevier BV, 2014. https://doi.org/10.1016/j.humimm.2014.08.178.
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    • Wegner, W., A. Clark, and D. Chen. “Identification of Specific and Non-Specific HLA Class II Antibodies in Solid Organ Transplantation.” In Transplantation, 98:805–6. Ovid Technologies (Wolters Kluwer Health), 2014. https://doi.org/10.1097/00007890-201407151-02753.
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    • Wegner, W., A. Clark, and D. Chen. “Identification of Specific and Non-Specific HLA Class II Antibodies in Solid Organ Transplantation.” In American Journal of Transplantation, 14:805–6, 2014.
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    • Wan, L., and D. Chen. “Quantitative Relationship of Luminex Single Antigen Bead Assay (LSA), Antibody Titration and Flow Crossmatch in Heart Transplantation - A Data Analysis of 5 Years Clinical Testing.” In American Journal of Transplantation, 13:70–70, 2013.
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    • Egnaczyk, G. F., D. -. F. Chen, C. B. Patel, K. R. White, G. M. Felker, P. Rosenberg, A. F. Hernandez, C. A. Milano, and J. G. Rogers. “42 The Importance of Low-Titer Anti-HLA Antibodies in Cardiac Transplantation.” In The Journal of Heart and Lung Transplantation, 30:S21–S21. Elsevier BV, 2011. https://doi.org/10.1016/j.healun.2011.01.049.
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    • Reinsmoen, N. L., D. Chen, M. James, S. Palmer, A. Finlen-Copeland, and R. D. Davis. “25: Donor Specific Antibody (DSA) as a Time Dependent Predictor Shows a Significant Negative Impact on Survival in Lung Recipients (Recips) Regardless of Pretransplant (Pretx) Antibody (Ab) Status.” In The Journal of Heart and Lung Transplantation, 29:S14–15. Elsevier BV, 2010. https://doi.org/10.1016/j.healun.2009.11.032.
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    • Reinsmoen, Nancy L., Dongfeng Chen, James Mirocha, Scott Palmer, Ashley Finlen-Copeland, and R Duane Davis. “125-P: Long-term outcome of lung recipients sensitized to HLA (Ab+recips) receiving desensitization (DS) therapy.” In Human Immunology, 70:S74–S74. Elsevier BV, 2009. https://doi.org/10.1016/j.humimm.2009.09.158.
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    • Chen, Dongfeng, Deepak Vikraman, Bradley H. Collins, Matthew T. Harris, and Janet E. Tuttle-Newhall. “Intracellular ATP Levels after Liver Transplant Are Associated with Fungal Infections and Increased Risk of Death.” In American Journal of Transplantation, 9:638–39. WILEY-BLACKWELL PUBLISHING, INC, 2009.
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    • Chen, D., V. Prasad, G. Broadwater, A. Clark, D. Rizzieri, N. Chao, and N. Reinsmoen. “Impact of inhibitory and activating KIR and HLA ligands in non-myeloablative haplo hematopoietic transplants in patients with high-risk myeloid malignancy.” In Tissue Antigens, 72:292–93, 2008.
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    • Chen, D., V. Prasad, G. Broadwater, A. Clark, D. Rizzieri, N. Chao, and N. Reinsmoen. “Impact of inhibitory and activating KIR and HLA ligands in non-myeloablative haplo hematopoietic transplants in patients with high-risk myeloid malignancy.” In Tissue Antigens, 72:302–3, 2008.
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    • Prasad, V., D. Chen, G. Broadwater, N. Reinsmoen, A. Clark, N. Chao, and D. Rizzieri. “Impact of inhibitory and activating KIR and HLA ligands in non-myeloablative haplo hematopoietic transplants in patients with high-risk lymphoid malignancy.” In Tissue Antigens, 72:302–302, 2008.
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