Carol Dukes Hamilton

Journal article Int J Tuberc Lung Dis · July 2006 Featured Publication SETTING: North Carolina, USA. OBJECTIVE: To understand physicians' knowledge and attitudes toward the treatment of young children with latent tuberculosis infection (LTBI) in a low-incidence region. DESIGN: Cross-sectional survey of 525 pediatricians and 5 ... Link to item Cite

Racial and ethnic disparities in pediatric tuberculosis in North Carolina.

Journal article Arch Pediatr Adolesc Med · June 2006 Featured Publication OBJECTIVES: To investigate an increase in active pediatric tuberculosis (TB) cases in North Carolina from 9 cases in 2001 to 32 cases in 2002, and to pilot test a screening tool for detection of latent TB infection in children. DESIGN: Retrospective cohort ... Full text Link to item Cite

Medicine. A portfolio model of drug development for tuberculosis.

Journal article Science · March 3, 2006 Featured Publication Full text Link to item Cite

Current issues in global tuberculosis control.

Journal article Int J Infect Dis · November 2005 Featured Publication Despite attempts to standardize tuberculosis (TB) control strategies, there remains wide variation in the selection and implementation of control strategies within and among nations. Some of this variation is appropriate; based on wide variations in the av ... Full text Link to item Cite

Immunosuppression related to collagen-vascular disease or its treatment.

Journal article Proc Am Thorac Soc · 2005 Featured Publication Collagen-vascular diseases are associated with immune dysregulation and inflammation, leading to tissue destruction or compromise. Immunosuppression is more commonly associated with the drugs used to treat these disorders than with the diseases themselves. ... Full text Link to item Cite

Infectious complications of treatment with biologic agents.

Journal article Curr Opin Rheumatol · July 2004 Featured Publication PURPOSE OF REVIEW: There are three tumor necrosis factor-alpha inhibitors on the US and European markets today, and uncommon but devastating infectious complications accompany their use. This review describes the most important pathogen-specific infections ... Full text Link to item Cite

Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis.

Journal article Am J Respir Crit Care Med · March 15, 2003 Featured Publication An alternative regimen for the treatment of latent tuberculosis infection is 2 months of rifampin and pyrazinamide, but some patients have died of hepatitis associated with this therapy. One hundred fourteen patients received rifampin/pyrazinamide in Wake ... Full text Link to item Cite

Reactivation of retinal toxoplasmosis despite evidence of immune response to highly active antiretroviral therapy.

Journal article Clin Infect Dis · August 15, 2002 Featured Publication We report a case of retinal toxoplasmosis that occurred in a patient with acquired immunodeficiency syndrome who had a previous diagnosis of cerebral toxoplasmosis, despite the patient having had a robust immune response to highly active antiretroviral the ... Full text Link to item Cite

A prospective, randomized, double-blind study of the tolerability of rifapentine 600, 900, and 1,200 mg plus isoniazid in the continuation phase of tuberculosis treatment.

Journal article Am J Respir Crit Care Med · June 1, 2002 Featured Publication Once-weekly rifapentine 600 mg plus isoniazid (INH) during the continuation phase treatment of tuberculosis is associated with a relapse rate higher than that of twice-weekly rifampin plus INH. The safety and tolerability of higher rifapentine doses need t ... Full text Link to item Cite

Epidemiology of human immunodeficiency virus testing among patients with tuberculosis in North Carolina.

Journal article South Med J · February 2002 Featured Publication BACKGROUND: Human immunodeficiency virus (HIV) testing is recommended for all patients with tuberculosis (TB). METHODS: Surveillance data for all reported cases of TB in North Carolina from 1993 to 1999 were examined to assess HIV testing practices. RESULT ... Link to item Cite

Hospital management of tuberculosis in a region with a low incidence of tuberculosis and a high prevalence of nontuberculous mycobacteria.

Journal article Infect Control Hosp Epidemiol · November 2001 Featured Publication We prospectively assessed the management of patients with suspected tuberculosis (TB) in an area with a high prevalence of nontuberculous mycobacteria (NTM) and a low incidence of TB. Clinicians' assessments were sensitive for TB but had poor predictive va ... Full text Link to item Cite

Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection.

Journal article J Infect Dis · July 15, 2001 Featured Publication Many human immunodeficiency virus (HIV)-infected persons receive prolonged treatment with DNA-reactive antiretroviral drugs. A prospective study was conducted of 26 HIV-infected men who provided samples before treatment and at multiple times after beginnin ... Full text Link to item Cite

Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant.

Journal article J Infect Dis · June 1, 2001 Featured Publication To confirm the vertical transmission of multidrug-resistant (MDR) human immunodeficiency virus type 1 (HIV-1) and to assess its impact on further evolution of drug-resistant virus in an infant, proviral DNA amplified from infected peripheral blood mononucl ... Full text Link to item Cite

Antepartum or postpartum isoniazid treatment of latent tuberculosis infection.

Journal article Obstet Gynecol · November 2000 Featured Publication OBJECTIVE: To compare health outcomes and costs of different strategies for treatment of latent tuberculosis infection in pregnancy. METHODS: Using a Markov decision-analysis model, the following three strategies were evaluated for treatment of latent tube ... Full text Link to item Cite

Excessive use of vancomycin: a successful intervention strategy at an academic medical center.

Journal article Infect Control Hosp Epidemiol · January 2000 Featured Publication The project goal was to decrease excessive vancomycin use. Interventions included an educational chart note the first day of therapy, followed by pharmacists discussing the need for continued therapy with patients' physicians. Empirical vancomycin use impr ... Full text Link to item Cite