Eda Yildirim | Scholars@Duke

Eda Yildirim
Assistant Professor of Cell Biology

1. Epigenetic mechanisms regulated by long noncoding RNAs: their regulatory roles in gene expression, genome stability and cell fate decisions.
2. Nuclear structure: its role in gene expression and genome function.

Current Appointments & Affiliations

Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2014
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016

Contact Information

3709, DUMC, 371B Nanaline Duke Bldg., Durham, NC 27710
3709, Nanaline Duke Rm 371B, Durham, NC 27710
eda.yildirim@duke.edu (919) 668-0460
Duke Cell Biology Department_Yildirim Lab
The Yildirim Lab at Duke Cell Biology

Background
Education, Training, & Certifications
- Ph.D., University of California at Los Angeles 2005
Leadership & Clinical Positions at Duke
- Co-director, Duke Epigenetics and Epigenomics Program
Recognition
In the News
- OCT 1, 2015
  
  Eda Yildirim: Solving for X, the Chromosome
- FEB 28, 2013 Nature Review Cancer
  
  Non-coding RNAs: The cancer X factor
Awards & Honors
- Whitehead Scholar Award. Duke University. 2014
Expertise
Subject Headings
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Xist long noncoding RNA mediated gene expression and epigenetic stability in hematologic malignancies awarded by Leukemia Research Foundation, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Book Sections
  - Yang T, Shi Y, Yildirim E. Implications of Long Noncoding RNAs in Cancer Epigenetics. In: Chakrabarti J, editor. Cancer and Noncoding RNAs. UK: Academic Press; 2017 Oct 17. (Chapter) Full Text Link to Item
- Journal Articles
  - Yang T, Yildirim E. Epigenetic and LncRNA-Mediated Regulation of X Chromosome Inactivation and Its Impact on Pathogenesis. Current Pathobiology Reports. 2017 Mar;5(1):1-12. Full Text
  - Savol AJ, Wang PI, Jeon Y, Colognori D, Yildirim E, Pinter SF, Payer B, Lee JT, Sadreyev RI. Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. PloS one. 2017 Jan;12(8):e0182568-. PubMed PMID: 28796844. Full Text Open Access Copy
  - Pinter SF, Colognori D, Beliveau BJ, Sadreyev RI, Payer B, Yildirim E, Wu C-T, Lee JT. Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. Genetics. 2015 Jun;200(2):537-549. PubMed PMID: 25858912. Full Text
  - O'Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, Yildirim E, Staropoli JF, Lee JT, Brown DE. Practical murine hematopathology: a comparative review and implications for research. Comparative Medicine. 2015 Apr;65(2):96-113. PubMed PMID: 25926395. (Review)
  - Sadreyev RI, Yildirim E, Pinter SF, Lee JT. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proceedings of the National Academy of Sciences of the United States of America. 2013 Apr 5;110(17):6949-6954. PubMed PMID: 23564346. Full Text
  - Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 2013 Feb;152(4):727-742. PubMed PMID: 23415223. Full Text
  - Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome research. 2012 Oct;22(10):1864-1876. PubMed PMID: 22948768. Full Text
  - Yildirim E, Carey MA, Card JW, Dietrich A, Flake GP, Zhang Y, Bradbury JA, Rebolloso Y, Germolec DR, Morgan DL, Zeldin DC, Birnbaumer L. Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. American journal of physiology. Lung cellular and molecular physiology. 2012 Sep;303(6):L539-L549. PubMed PMID: 22797250. Full Text
  - Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nature structural & molecular biology. 2011 Dec 4;19(1):56-61. PubMed PMID: 22139016. Full Text
  - Liu X, Cheng KT, Bandyopadhyay BC, Pani B, Dietrich A, Paria BC, Swaim WD, Beech D, Yildrim E, Singh BB, Birnbaumer L, Ambudkar IS. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 23;104(44):17542-17547. PubMed PMID: 17956991. Full Text
  - Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong DL, Birnbaumer L. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 7;104(11):4682-4687. PubMed PMID: 17360584. Full Text
  - Yildirim E, Birnbaumer L. TRPC2: molecular biology and functional importance. Handbook of experimental pharmacology. 2007 Jan;(179):53-75. PubMed PMID: 17217050. (Review) Full Text
  - Dietrich A, Mederos y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L. Increased Vascular Smooth Muscle Contractility in TRPC6-/- Mice. Molecular and Cellular Biology. 2005 Dec 15;25(24):11191-11191. Full Text
  - Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L. Increased vascular smooth muscle contractility in TRPC6-/- mice. Molecular and cellular biology. 2005 Aug;25(16):6980-6989. PubMed PMID: 16055711. Full Text
  - Yildirim E, Kawasaki BT, Birnbaumer L. Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar;102(9):3307-3311. PubMed PMID: 15728370. Full Text
  - Dietrich A, Schnitzler MMY, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L. Erratum: Increased vascular smooth muscle contractility in TRPC6 ^-/- mice (Molecular and Cellular Biology (2005) 25, 16 (6980-6989)). Molecular and Cellular Biology. 2005;25(24):11191--. Full Text
  - Erratum to “A comparison of the genes coding for canonical TRP channels and their M, V and P relatives” [Cell Calcium 33 (2003) 419–432]. Cell Calcium. 2003 Dec;34(6):517-517. Full Text
  - Birnbaumer L, Yildirim E, Abramowitz J. A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. Cell calcium. 2003 May;33(5-6):419-432. PubMed PMID: 12765687. Full Text
  - Yildirim E, Dietrich A, Birnbaumer L. The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Proceedings of the National Academy of Sciences of the United States of America. 2003 Mar;100(5):2220-2225. PubMed PMID: 12601176. Full Text
  - Birnbaumer L, Yildirim E, Abramowitz J. Erratum: "A comparison of the genes coding for canonical TRP channels and their M, V and P relatives" (Cell Calcium (2003) vol. 33 (419-432)). Cell Calcium. 2003;34(6):517--. Full Text
Teaching & Mentoring
Recent Courses
- CELLBIO 493: Research Independent Study 2018
- CMB 710E: Cell & Molecular Biology Module V 2018
Scholarly, Clinical, & Service Activities
Service to Duke
- Duke University Basic Sciences Faculty Steering Committee. 2015 2015

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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Book Sections

Journal Articles

Recent Courses

Service to Duke