Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of California at Los Angeles 2005
• Recognition
• 

  In the News

  • OCT 1, 2015

    Eda Yildirim: Solving for X, the Chromosome
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  Awards & Honors

  • Whitehead Scholar Award. Duke University. 2014
• Expertise
• 

  Subject Headings

  • Bone Marrow
  • Cancer
  • Cell Biology
  • Chromosome abnormalities
  • Chromosomes
  • Epigenetics
  • Gene Expression Regulation
  • Hematopoietic Stem Cells
  • Nuclear Envelope
  • X Chromosome
  • X chromosome--Abnormalities
• Research
• 

  Selected Grants

  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Xist long noncoding RNA mediated gene expression and epigenetic stability in hematologic malignancies awarded by Leukemia Research Foundation, Inc. 2015 - 2016
• Publications & Artistic Works
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  Selected Publications

  • Journal Articles

    • Savol, AJ, Wang, PI, Jeon, Y, Colognori, D, Yildirim, E, Pinter, SF, Payer, B, Lee, JT, and Sadreyev, RI. "Genome-wide identification of autosomal genes with allelic imbalance of chromatin state." PloS one 12, no. 8 (January 2017): e0182568-.  Full Text
    • Pinter, SF, Colognori, D, Beliveau, BJ, Sadreyev, RI, Payer, B, Yildirim, E, Wu, C-T, and Lee, JT. "Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome." Genetics 200, no. 2 (June 2015): 537-549.  Full Text
    • O'Connell, KE, Mikkola, AM, Stepanek, AM, Vernet, A, Hall, CD, Sun, CC, Yildirim, E, Staropoli, JF, Lee, JT, and Brown, DE. "Practical murine hematopathology: a comparative review and implications for research." Comparative Medicine 65, no. 2 (April 2015): 96-113. (Review)
    • Sadreyev, RI, Yildirim, E, Pinter, SF, and Lee, JT. "Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci." Proceedings of the National Academy of Sciences of the United States of America 110, no. 17 (April 5, 2013): 6949-6954.  Full Text
    • Yildirim, E, Kirby, JE, Brown, DE, Mercier, FE, Sadreyev, RI, Scadden, DT, and Lee, JT. "Xist RNA is a potent suppressor of hematologic cancer in mice." Cell 152, no. 4 (February 2013): 727-742.  Full Text
    • Pinter, SF, Sadreyev, RI, Yildirim, E, Jeon, Y, Ohsumi, TK, Borowsky, M, and Lee, JT. "Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations." Genome research 22, no. 10 (October 2012): 1864-1876.  Full Text
    • Yildirim, E, Carey, MA, Card, JW, Dietrich, A, Flake, GP, Zhang, Y, Bradbury, JA, Rebolloso, Y, Germolec, DR, Morgan, DL, Zeldin, DC, and Birnbaumer, L. "Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice." American journal of physiology. Lung cellular and molecular physiology 303, no. 6 (September 2012): L539-L549.  Full Text
    • Yildirim, E, Sadreyev, RI, Pinter, SF, and Lee, JT. "X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription." Nature structural & molecular biology 19, no. 1 (December 4, 2011): 56-61.  Full Text
    • Liu, X, Cheng, KT, Bandyopadhyay, BC, Pani, B, Dietrich, A, Paria, BC, Swaim, WD, Beech, D, Yildrim, E, Singh, BB, Birnbaumer, L, and Ambudkar, IS. "Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice." Proceedings of the National Academy of Sciences of the United States of America 104, no. 44 (October 23, 2007): 17542-17547.  Full Text
    • Liao, Y, Erxleben, C, Yildirim, E, Abramowitz, J, Armstrong, DL, and Birnbaumer, L. "Orai proteins interact with TRPC channels and confer responsiveness to store depletion." Proceedings of the National Academy of Sciences of the United States of America 104, no. 11 (March 7, 2007): 4682-4687.  Full Text
    • Yildirim, E, and Birnbaumer, L. "TRPC2: molecular biology and functional importance." Handbook of experimental pharmacology , no. 179 (January 2007): 53-75. (Review)  Full Text
    • Dietrich, A, Mederos y Schnitzler, M, Gollasch, M, Gross, V, Storch, U, Dubrovska, G, Obst, M, Yildirim, E, Salanova, B, Kalwa, H, Essin, K, Pinkenburg, O, Luft, FC, Gudermann, T, and Birnbaumer, L. "Increased Vascular Smooth Muscle Contractility in TRPC6-/- Mice." Molecular and Cellular Biology 25, no. 24 (December 15, 2005): 11191-11191.  Full Text
    • Dietrich, A, Mederos Y Schnitzler, M, Gollasch, M, Gross, V, Storch, U, Dubrovska, G, Obst, M, Yildirim, E, Salanova, B, Kalwa, H, Essin, K, Pinkenburg, O, Luft, FC, Gudermann, T, and Birnbaumer, L. "Increased vascular smooth muscle contractility in TRPC6-/- mice." Molecular and cellular biology 25, no. 16 (August 2005): 6980-6989.  Full Text
    • Yildirim, E, Kawasaki, BT, and Birnbaumer, L. "Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel." Proceedings of the National Academy of Sciences of the United States of America 102, no. 9 (March 2005): 3307-3311.  Full Text
    • Dietrich, A, Schnitzler, MMY, Gollasch, M, Gross, V, Storch, U, Dubrovska, G, Obst, M, Yildirim, E, Salanova, B, Kalwa, H, Essin, K, Pinkenburg, O, Luft, FC, Gudermann, T, and Birnbaumer, L. "Erratum: Increased vascular smooth muscle contractility in TRPC6 ^-/- mice (Molecular and Cellular Biology (2005) 25, 16 (6980-6989))." Molecular and Cellular Biology 25, no. 24 (2005): 11191--.  Full Text
    • "Erratum to “A comparison of the genes coding for canonical TRP channels and their M, V and P relatives” [Cell Calcium 33 (2003) 419–432]." Cell Calcium 34, no. 6 (December 2003): 517-517.  Full Text
    • Birnbaumer, L, Yildirim, E, and Abramowitz, J. "A comparison of the genes coding for canonical TRP channels and their M, V and P relatives." Cell calcium 33, no. 5-6 (May 2003): 419-432.  Full Text
    • Yildirim, E, Dietrich, A, and Birnbaumer, L. "The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus." Proceedings of the National Academy of Sciences of the United States of America 100, no. 5 (March 2003): 2220-2225.  Full Text
    • Birnbaumer, L, Yildirim, E, and Abramowitz, J. "Erratum: "A comparison of the genes coding for canonical TRP channels and their M, V and P relatives" (Cell Calcium (2003) vol. 33 (419-432))." Cell Calcium 34, no. 6 (2003): 517--.  Full Text
• Teaching & Mentoring
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  Recent Courses

  • CELLBIO 493: Research Independent Study 2018
  • CMB 710E: Cell & Molecular Biology Module V 2018
• Scholarly, Clinical, & Service Activities
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  Service to Duke

  • Duke University Basic Sciences Faculty Steering Committee. 2015  2015

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