Eda Yildirim | Scholars@Duke

Eda Yildirim
Assistant Professor of Cell Biology

1. Epigenetic mechanisms regulated by long noncoding RNAs: their regulatory roles in gene expression, genome stability and cell fate decisions.
2. Nuclear structure: its role in gene expression and genome function.

Current Appointments & Affiliations

Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2014
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

3709, Dumc, 412A Nanaline Duke Bldg., Durham, NC 27710
DUMC 3709, Nanaline Duke Rm 412A, Durham, NC 27710
eda.yildirim@duke.edu (919) 668-0460
Duke Cell Biology Department_Yildirim Lab
The Yildirim Lab at Duke Cell Biology

Background
Education, Training, & Certifications
- Ph.D., University of California - Los Angeles 2005
Leadership & Clinical Positions at Duke
- Co-director, Duke Epigenetics and Epigenomics Program
Recognition
In the News
- OCT 1, 2015
  
  Eda Yildirim: Solving for X, the Chromosome
- FEB 28, 2013 Nature Review Cancer
  
  Non-coding RNAs: The cancer X factor
Awards & Honors
- Whitehead Scholar Award. Duke University. 2014
Expertise
Subject Headings
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Mechanisms of myeloid cells dysregulation in radiation survivors awarded by Columbia University 2022 - 2023
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Xist long noncoding RNA mediated gene expression and epigenetic stability in hematologic malignancies awarded by Leukemia Research Foundation, Inc. 2015 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Yang T, Ou J, Yildirim E. Xist exerts gene-specific silencing during XCI maintenance and impacts lineage-specific cell differentiation and proliferation during hematopoiesis. Nat Commun. 2022 Aug 1;13(1):4464.
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  - Cao J, Verma SK, Jaworski E, Mohan S, Nagasawa CK, Rayavara K, et al. RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts. Cell Rep. 2021 Nov 2;37(5):109910.
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  - Kadota S, Ou J, Shi Y, Lee JT, Sun J, Yildirim E. Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Nat Commun. 2020 May 25;11(1):2606.
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  - Yang L, Yildirim E, Kirby JE, Press W, Lee JT. Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4262–72.
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  - Sun J, Shi Y, Yildirim E. The Nuclear Pore Complex in Cell Type-Specific Chromatin Structure and Gene Regulation. Trends Genet. 2019 Aug;35(8):579–88.
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  - Yang T, Yildirim E. Epigenetic and LncRNA-Mediated Regulation of X Chromosome Inactivation and Its Impact on Pathogenesis. Current Pathobiology Reports. 2017 Mar 1;5(1).
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  - Savol AJ, Wang PI, Jeon Y, Colognori D, Yildirim E, Pinter SF, et al. Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. Plos One. 2017;12(8):e0182568.
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  - Pinter SF, Colognori D, Beliveau BJ, Sadreyev RI, Payer B, Yildirim E, et al. Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. Genetics. 2015 Jun;200(2):537–49.
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  - O’Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, et al. Practical murine hematopathology: a comparative review and implications for research. Comp Med. 2015 Apr;65(2):96–113.
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  - Sadreyev RI, Yildirim E, Pinter SF, Lee JT. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6949–54.
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  - Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, et al. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 2013 Feb 14;152(4):727–42.
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  - Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, et al. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Res. 2012 Oct;22(10):1864–76.
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  - Yildirim E, Carey MA, Card JW, Dietrich A, Flake GP, Zhang Y, et al. Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L539–49.
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  - Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nat Struct Mol Biol. 2011 Dec 4;19(1):56–61.
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  - Liu X, Cheng KT, Bandyopadhyay BC, Pani B, Dietrich A, Paria BC, et al. Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17542–7.
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  - Liao Y, Erxleben C, Yildirim E, Abramowitz J, Armstrong DL, Birnbaumer L. Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4682–7.
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  - Yildirim E, Birnbaumer L. TRPC2: molecular biology and functional importance. Handb Exp Pharmacol. 2007;(179):53–75.
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  - Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, et al. Erratum: Increased vascular smooth muscle contractility in TRPC6 ^-/- mice (Molecular and Cellular Biology (2005) 25, 16 (6980-6989)). Molecular and Cellular Biology. 2005 Dec 1;25(24):11191.
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  - Dietrich A, Mederos Y Schnitzler M, Gollasch M, Gross V, Storch U, Dubrovska G, et al. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol. 2005 Aug;25(16):6980–9.
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  - Yildirim E, Kawasaki BT, Birnbaumer L. Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3307–11.
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  - Yildirim E, Dietrich A, Birnbaumer L. The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2220–5.
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  - Birnbaumer L, Yildirim E, Abramowitz J. Erratum: "A comparison of the genes coding for canonical TRP channels and their M, V and P relatives" (Cell Calcium (2003) vol. 33 (419-432)). Cell Calcium. 2003 Jan 1;34(6):517.
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  - Birnbaumer L, Yildirim E, Abramowitz J. A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. Cell Calcium. 2003;33(5–6):419–32.
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- Book Sections
  - Yang T, Shi Y, Yildirim E. Implications of Long Noncoding RNAs in Cancer Epigenetics. In: Chakrabarti J, editor. Cancer and Noncoding RNAs. UK: Academic Press; 2017.
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  - Abramowitz J, Yildirim E, Birnbaumer L. The TRPC Family of Ion Channels. In: TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. CRC Press; 2006. p. 1–30.
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- Conference Papers
  - Birnbaumer L, Yildirim E, Liao Y, Abramowitz J. Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE. In Springer Berlin Heidelberg; p. 1–22.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Service to Duke
- Duke University Basic Sciences Faculty Steering Committee. 2015 2015

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Education, Training, & Certifications

Leadership & Clinical Positions at Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses

Service to Duke