Edward Daniel Levin

Journal article Behav Genet · July 2005 Featured Work Extracellular superoxide dismutase (EC-SOD) plays an important role in controlling oxidative stress as well as intercellular signaling. In the current study, we tested the effect of EC-SOD overexpression over the lifespan of a set of mice and their wild-ty ... Full text Link to item Cite

Fetal nicotinic overload, blunted sympathetic responsivity, and obesity.

Journal article Birth Defects Res A Clin Mol Teratol · July 2005 Featured Work Full text Link to item Cite

Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions.

Journal article Neuropsychopharmacology · June 2005 Featured Work Clozapine is an effective antipsychotic drug, but its effects on cognitive function are unclear. Previously, we found that clozapine caused a working memory deficit, which was reversed by nicotine. Hippocampal systems are important in determining clozapine ... Full text Link to item Cite

Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.

Journal article Brain Res · April 18, 2005 Featured Work Chronic nicotine administration has long been known to increase the number of high-affinity alpha4beta2 nicotinic receptors with lesser effects on low-affinity alpha7 nicotinic receptors. Nicotine has been shown to promote the release of a variety of neuro ... Full text Link to item Cite

Persisting behavioral consequences of prenatal domoic acid exposure in rats.

Journal article Neurotoxicol Teratol · 2005 Featured Work To investigate the behavioral effects of prenatal exposure to the marine toxin domoic acid, pregnant female rats were injected subcutaneously with 0, 0.3, 0.6, or 1.2 mg/kg of domoic acid on gestational day 13. The offspring were then run through a behavio ... Full text Link to item Cite

Nicotine-antipsychotic drug interactions and attentional performance in female rats.

Journal article Eur J Pharmacol · February 20, 2004 Featured Work Schizophrenia is marked by pronounced cognitive impairments in addition to the hallmark psychotic symptoms like hallucinations. Antipsychotic drugs can effectively reduce these hallucinations; however, the drugs have not resolved the cognitive impairment. ... Full text Link to item Cite

Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment.

Journal article Psychopharmacology (Berl) · February 2004 Featured Work OBJECTIVES: Chronic transdermal nicotine has been found to improve attentional performance in patients with Alzheimer's disease (AD), but little is known about chronic nicotine effects in age-associated memory impairment (AAMI), a milder form of cognitive ... Full text Link to item Cite

Nicotinic involvement in memory function in zebrafish.

Journal article Neurotoxicol Teratol · 2004 Featured Work Zebrafish are an emerging model for the study of the molecular mechanisms of brain function. To conduct studies of the neural bases of behavior in zebrafish, we must understand the behavioral function of zebrafish and how it is altered by perturbations of ... Full text Link to item Cite

Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior.

Journal article Neurotoxicol Teratol · 2004 Featured Work Chlorpyrifos (CPF), a widely used organophosphate insecticide and potent acetylcholinesterase inhibitor, interferes with neurobehavioral development. Rat models have been key in demonstrating that developmental CPF exposure causes learning deficits and loc ... Full text Link to item Cite

Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.

Journal article Neurotoxicol Teratol · 2004 Featured Work The widely used organophosphate insecticide, chlorpyrifos (CPF), elicits neurobehavioral abnormalities after apparently subtoxic neonatal exposures. In the current study, we administered 1 or 5 mg/kg/day of CPF to pregnant rats on gestational days 9-12, th ... Full text Link to item Cite