Edward Hecht Bossen | Scholars@Duke

Edward Hecht Bossen
Professor Emeritus of Pathology

My scholarly activities at present are limited to clinicopathologic correlations with specific interest in head and neck pathology and skeletal muscle.

Current Appointments & Affiliations

Professor Emeritus of Pathology, Pathology, Clinical Science Departments 2012

Contact Information

227 Hosp South, Durham, NC 27710
Duke Box 3712, Department Of Pathology, Durham, NC 27710
edward.bossen@duke.edu (919) 684-2332

Background
Education, Training, & Certifications
- Assistant Professor, Pathology, Duke University 1972 - 1983
- Associate Professor, Pathology, Dartmouth College 1976 - 1980
- Fellow, Pathology, Duke University 1968 - 1970
- Resident, Pathology, Duke University 1966 - 1968
- Intern, Pathology, Duke University 1965 - 1966
- M.D., Duke University 1965
- B.S., University of Florida 1961
Duke Appointment History
- Professor of Pathology, Pathology, Clinical Science Departments 1980 - 2012
- Associate Professor of Pathology, Pathology, Clinical Science Departments 1976 - 1980
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 1972 - 1976
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mori, M, Goldstein, J, Young, SP, Bossen, EH, Shoffner, J, and Koeberl, DD. "Complex III deficiency due to an in-frame MT-CYB deletion presenting as ketotic hypoglycemia and lactic acidosis." Molecular genetics and metabolism reports 4 (September 2015): 39-41. Full Text
  - Buckley, AF, and Bossen, EH. "Skeletal muscle microvasculature in the diagnosis of neuromuscular disease." J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906-918. (Review) Full Text Link to Item
  - Thurberg, BL, Lynch Maloney, C, Vaccaro, C, Afonso, K, Tsai, AC-H, Bossen, E, Kishnani, PS, and O'Callaghan, M. "Characterization of pre- and post-treatment pathology after enzyme replacement therapy for Pompe disease." Laboratory Investigation; a Journal of Technical Methods and Pathology 86, no. 12 (December 2006): 1208-1220. Full Text
  - Luna, A, Martinez, S, and Bossen, E. "Magnetic resonance imaging of intramuscular myxoma with histological comparison and a review of the literature." Skeletal Radiology 34, no. 1 (2005): 19-28. Full Text
  - Lansford, CD, Bossen, EH, and Scher, RL. "Pathology quiz case 1. Hairy polyp." Arch Otolaryngol Head Neck Surg 129, no. 3 (March 2003): 369-371. Link to Item
  - Lansford, CD, Bossen, EH, and Scher, RL. "Pathology quiz case 1." Archives of Otolaryngology Head and Neck Surgery 129, no. 3 (March 1, 2003). Full Text
  - Tim, RW, Gilbert, JR, Stajich, JM, Rampersaud, E, Viles, KD, Tawil, R, Padberg, GW, Frants, R, van der Maarel, S, Bossen, EH, Friedman, AH, Pericak-Vance, MA, and Speer, MC. "Clinical Studies in Non-chromosome 4-Linked Facioscapulohumeral Muscular Dystrophy." J Clin Neuromuscul Dis 3, no. 1 (September 2001): 1-7. Link to Item
  - Amalfitano, A, Bengur, AR, Morse, RP, Majure, JM, Case, LE, Veerling, DL, Mackey, J, Kishnani, P, Smith, W, McVie-Wylie, A, Sullivan, JA, Hoganson, GE, Phillips, JA, Schaefer, GB, Charrow, J, Ware, RE, Bossen, EH, and Chen, YT. "Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial." Genetics in Medicine : Official Journal of the American College of Medical Genetics 3, no. 2 (March 2001): 132-138.
  - Bettencourt, MS, Burton, CS, Prieto, VG, Bossen, EH, and Shea, CR. "Recurrent papules on the left upper extremity of a 50-year-old man." Arch Dermatol 137, no. 3 (March 2001): 365-370. Link to Item
  - Bettencourt, MS, Burton, CS, Prieto, VG, Bossen, EH, and Shea, CR. "Recurrent papules on the left upper extremity of a 50-year-old man - Epithelioid hemangioendothelioma (EHE)." ARCHIVES OF DERMATOLOGY 137, no. 3 (March 2001): 365-+. Link to Item
  - O???GRADY, MICHAEL, HACKNEY, ANTHONYC, SCHNEIDER, KENNETH, BOSSEN, EDWARD, STEINBERG, KARL, DOUGLAS, JAMESM, MURRAY, WILLIAMJ, and WATKINS, WDAVID. "Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle." Medicine & Science in Sports & Exercise 32, no. 7 (July 2000): 1191-1196. Full Text
  - Morse, MA, Bossen, E, D'Amico, TA, Williamson, W, and Johnson, R. "Myxoid liposarcoma of the supraclavicular fossa." Chest 117, no. 5 (May 2000): 1518-1520. Link to Item
  - Mooney, EE, Dodd, LG, Vollmer, RT, and Bossen, EH. "Fine-needle aspiration biopsy diagnosis of primary bronchial basaloid-squamous carcinoma." Diagn Cytopathol 16, no. 2 (February 1997): 187-188. (Letter) Link to Item
  - Kishnani, PS, Van Hove, JL, Shoffner, JS, Kaufman, A, Bossen, EH, and Kahler, SG. "Acute pancreatitis in an infant with lactic acidosis and a mutation at nucleotide 3243 in the mitochondrial DNA tRNALeu(UUR) gene." Eur J Pediatr 155, no. 10 (October 1996): 898-903. Link to Item
  - Van Hove, JL, Shanske, S, Ciacci, F, Ballinger, S, Shoffner, JS, Wallace, DC, Hanioka, T, Folkers, K, Bossen, EH, and Kussin, PS. "Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis: a distinct late onset mitochondrial disorder." Am J Med Genet 51, no. 2 (June 1, 1994): 114-120. Full Text Link to Item
  - Acker, JC, Bossen, EH, and Halperin, EC. "The management of desmoid tumors." Int J Radiat Oncol Biol Phys 26, no. 5 (August 1, 1993): 851-858. Link to Item
  - Dresser, LP, Massey, EW, Johnson, EE, and Bossen, E. "Ipecac myopathy and cardiomyopathy." J Neurol Neurosurg Psychiatry 56, no. 5 (May 1993): 560-562. Link to Item
  - Chaopricha, W, Chen, LE, Seaber, AV, Bossen, E, and Urbaniak, JR. "Micro-anastomosis of 0.3-0.4 mm vessels after cold ischemia using a rat model of toe-to-thumb transplantation." Microsurgery 14, no. 9 (1993): 619-623. Link to Item
  - Wolf, HK, Garcia, JA, and Bossen, EH. "Oncocytic differentiation in intrahepatic biliary cystadenocarcinoma." Mod Pathol 5, no. 6 (November 1992): 665-668. Link to Item
  - Tharrington, CL, and Bossen, EH. "Nasopharyngeal teratomas." Arch Pathol Lab Med 116, no. 2 (February 1992): 165-167. (Review) Link to Item
  - Herzberg, AJ, Bossen, EH, and Walther, PJ. "Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management." Cancer 68, no. 5 (September 1991): 1015-1020. Full Text
  - Chen, LE, Seaber, AV, Bossen, E, and Urbaniak, JR. "The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model." J Orthop Res 9, no. 2 (March 1991): 266-274. Full Text Link to Item
  - Hug, G, Chuck, G, Chen, YT, Kay, HH, and Bossen, EH. "Chorionic villus ultrastructure in type II glycogen storage disease (Pompe's disease)." N Engl J Med 324, no. 5 (January 31, 1991): 342-343. (Letter) Full Text Link to Item
  - Sommer, JR, Bossen, E, Dalen, H, Dolber, P, High, T, Jewett, P, Johnson, EA, Junker, J, Leonard, S, and Nassar, R. "To excite a heart: a bird's view." Acta Physiologica Scandinavica. Supplementum 599 (January 1991): 5-21. (Review)
  - Friedman, HS, Colvin, OM, Aisaka, K, Popp, J, Bossen, EH, Reimer, KA, Powell, JB, Hilton, J, Gross, SS, and Levi, R. "Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity." Cancer Research 50, no. 8 (April 1990): 2455-2462.
  - Wolf, HK, Harrelson, JM, and Bossen, EH. "Multicentric malignant fibrous histiocytoma of soft tissue." Am J Surg Pathol 14, no. 2 (February 1990): 188-193. Link to Item
  - Benning, TL, and Bossen, EH. "Multilammelated structures in muscle external lamina." Ultrastruct Pathol 13, no. 1 (January 1989): 83-88. (Letter) Link to Item
  - Krendel, DA, Gilchrist, JM, and Bossen, EH. "Distal vacuolar myopathy with complete heart block." Arch Neurol 45, no. 6 (June 1988): 698-699. Link to Item
  - Bossen, EH. "Heterotopic brain tissue." Am J Surg Pathol 12, no. 1 (January 1988): 71-. (Letter) Link to Item
  - Bossen, EH, and Hudson, WR. "Oligodendroglioma arising in heterotopic brain tissue of the soft palate and nasopharynx." Am J Surg Pathol 11, no. 7 (July 1987): 571-574. Link to Item
  - Krendel, DA, Gilchrist, JM, Johnson, AO, and Bossen, EH. "Isolated deficiency of vitamin E with progressive neurologic deterioration." Neurology 37, no. 3 (March 1987): 538-540. Link to Item
  - BOSSEN, E. "Oligodendroglioma arising in heterotopic brain tissue of the soft palate and nasopharynx." Am J Surg Pathol 11 (1987): 571-574. Full Text
  - Wain, SL, Kier, R, Vollmer, RT, and Bossen, EH. "Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases." Hum Pathol 17, no. 11 (November 1986): 1158-1166. Link to Item
  - Borowitz, MJ, Weiss, MA, Bossen, EH, and Metzgar, RS. "Characterization of renal neoplasms with monoclonal antibodies to leukocyte differentiation antigens." Cancer 57, no. 2 (January 1986): 251-256. Full Text
  - Estrada, JC, Brinn, NT, and Bossen, EH. "A rapid method of staining ultrathin sections for surgical pathology TEM with the use of the microwave oven." Am J Clin Pathol 83, no. 5 (May 1985): 639-641. Link to Item
  - Silverman, PM, Bossen, EH, Fisher, SR, Cole, TB, Korobkin, M, and Halvorsen, RA. "Carcinoma of the larynx and hypopharynx: computed tomographic-histopathologic correlations." Radiology 151, no. 3 (June 1984): 697-702. Full Text
  - Szpak, CA, Bossen, EH, Linder, J, and Johnston, WW. "Cytomorphology of primary small-cell (Merkel-cell) carcinoma of the skin in fine needle aspirates." Acta Cytol 28, no. 3 (May 1984): 290-296. Link to Item
  - Bossen, EH, and Sommer, JR. "Comparative stereology of the lizard and frog myocardium." Tissue Cell 16, no. 2 (1984): 173-178. Link to Item
  - Croker, BP, Bossen, EH, Brinn, NT, and Hammond, FA. "A fixative for use in muscle histochemistry." J Histochem Cytochem 31, no. 1 (January 1983): 110-112. Full Text Link to Item
  - Alexander, CB, Croker, BP, and Bossen, EH. "Dermatomyositis associated with IgA deposition." Archives of Pathology & Laboratory Medicine 106, no. 9 (September 1982): 449-451.
  - Hamilton, CW, Shelburne, JD, Bossen, EH, and Lowe, JE. "A glomus tumor of the jejunum masquerading as a carcinoid tumor." Hum Pathol 13, no. 9 (September 1982): 859-861. Link to Item
  - Metzgar, RS, Gaillard, MT, Levine, SJ, Tuck, FL, Bossen, EH, and Borowitz, MJ. "Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies." Cancer Research 42, no. 2 (February 1982): 601-608.
  - JOHNSON, DG, OSBORNE, D, and BOSSEN, EH. "METASTASIS TO THE FEMUR FROM A BRONCHIAL CARCINOID-TUMOR - CASE-REPORT 185." SKELETAL RADIOLOGY 7, no. 4 (1982): 293-295. Full Text Link to Item
  - Johnson, DG, Osborne, D, and Bossen, EH. "Case report 185: metastasis to the femur from a bronchial carcinoid tumor." Skeletal Radiol 7, no. 4 (January 1982): 293-295. Link to Item
  - Johnson, DG, Osborne, D, and Bossen, EH. "Case report 185." Skeletal Radiology 7, no. 4 (January 1, 1982): 293-295. Full Text
  - Sommer, JR, Bossen, E, and Fabiato, A. "JUNCTIONAL SARCOPLASMIC RETICULUM IN EXCITATION-CONTRACTION-COUPLING." Proceedings - Electron Microscopy Society of America (1982): 136-137.
  - Johnston, WW, and Bossen, EH. "Ten years of respiratory cytopathology at Duke University Medical Center. II. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, with a comparison between cytopathology and histopathology in the typing of lung cancer." Acta Cytol 25, no. 5 (September 1981): 499-505. Link to Item
  - Johnston, WW, and Bossen, EH. "Ten years of respiratory cytopathology at Duke University Medical Center. I. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, noting the significance of specimen number and type." Acta Cytol 25, no. 2 (March 1981): 103-107. Link to Item
  - Bossen, EH, Sommer, JR, and Waugh, RA. "Comparative stereology of mouse atria." Tissue Cell 13, no. 1 (1981): 71-77. Link to Item
  - JOHNSTON, WW, and BOSSEN, EH. "10 YEARS OF RESPIRATORY CYTO-PATHOLOGY AT DUKE-UNIVERSITY MEDICAL-CENTER .2. THE CYTOPATHOLOGIC DIAGNOSIS OF LUNG-CANCER DURING THE YEARS 1970 TO 1974, WITH A COMPARISON BETWEEN CYTO-PATHOLOGY AND HISTOPATHOLOGY IN THE TYPING OF LUNG-CANCER." ACTA CYTOLOGICA 25, no. 5 (1981): 499-505. Link to Item
  - JOHNSTON, WW, and BOSSEN, EH. "10 YEARS OF RESPIRATORY CYTO-PATHOLOGY AT DUKE-UNIVERSITY-MEDICAL-CENTER .1. THE CYTOPATHOLOGIC DIAGNOSIS OF LUNG-CANCER DURING THE YEARS 1970 TO 1974, NOTING THE SIGNIFICANCE OF SPECIMEN NUMBER AND TYPE." ACTA CYTOLOGICA 25, no. 2 (1981): 103-107. Link to Item
  - Carson, KA, Bossen, EH, and Hanker, JS. "Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes." Neuropathol Appl Neurobiol 6, no. 5 (September 1980): 361-374. Link to Item
  - Hanker, JS, Ambrose, WW, James, CJ, Mandelkorn, J, Yates, PE, Gall, SA, Bossen, EH, Fay, JW, Laszlo, J, and Moore, JO. "Facilitated light microscopic cytochemical diagnosis of acute myelogenous leukemia." Cancer Res 39, no. 5 (May 1979): 1635-1639. Link to Item
  - Alexander, CB, and Bossen, EH. "Peripheral couplings in human skeletal muscle." Laboratory Investigation; a Journal of Technical Methods and Pathology 39, no. 1 (July 1978): 17-20.
  - Soules, MR, Abraham, GE, and Bossen, EH. "The steroid profile of a virilizing ovarian tumor." Obstet Gynecol 52, no. 1 (July 1978): 73-78. Link to Item
  - Michel, RG, Woodard, BH, Shelburne, JD, and Bossen, EH. "Ceruminous gland adenocarcinoma: a light and electron microscopic study." Cancer 41, no. 2 (February 1978): 545-553. Full Text
  - Bossen, EH, Sommer, JR, and Waugh, RA. "Comparative stereology of the mouse and finch left ventricle." Tissue Cell 10, no. 4 (1978): 773-784. Link to Item
  - Bossen, EH, and Johnston, WW. "Exfoliative cytopathologic studies in organ transplantation. V. The diagnosis of rejection in the immediate postoperative period." Acta Cytol 21, no. 4 (July 1977): 502-507. Link to Item
  - Gold, JH, Shelburne, JD, and Bossen, EH. "Meningeal mycosis fungoides: cytologic and ultrastructural aspects." Acta Cytol 20, no. 4 (July 1976): 349-355. Link to Item
  - Gold, JH, and Bossen, EH. "Benign vaginal rhabdomyoma: a light and electron microscopic study." Cancer 37, no. 5 (May 1976): 2283-2294. Full Text
  - Bossen, EH, and Johnston, WW. "Exfoliative cytopathologic studies in organ transplantation IV. The cytologic diagnosis of herpesvirus in the urine of renal allograft recipients." Acta Cytol 19, no. 5 (September 1975): 415-419. Link to Item
  - Bossen, EH, Shelburne, JD, and Verkauf, BS. "Respiratory muscle involvement in infantile myotonic dystrophy." Arch Pathol 97, no. 4 (April 1974): 250-252. Link to Item
  - Ilgen, CL, Bossen, EH, Rowlands, DT, and Burkholder, PM. "Isolation and characterization of C4-synthesizing cells from guinea-pig spleen." Immunology 26, no. 3 (March 1974): 659-665. Link to Item
  - Bossen, EH. "Myofiber inclusions." Am J Clin Pathol 59, no. 5 (May 1973): 763-. Link to Item
  - Bossen, EH, Lough, JW, and Hansen, JL. "The effects of chloroquine on chick skeletal muscle in vitro." Toxicol Appl Pharmacol 24, no. 2 (February 1973): 197-205. Link to Item
  - Lough, JW, Entman, ML, Bossen, EH, and Hansen, JL. "Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture." J Cell Physiol 80, no. 3 (December 1972): 431-436. Full Text Link to Item
  - Bossen, EH, and Rowlands, DT. "Localization of functionally different guinea-pig spleen cells in albumin gradients." Immunology 22, no. 3 (March 1972): 417-421. Link to Item
  - Rowlands, DT, Burkholder, PM, Bossen, EH, and Lin, HH. "Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies." Am J Pathol 61, no. 2 (November 1970): 177-210. Link to Item
  - Bossen, EH, Johnston, WW, Amatulli, J, and Rowlands, DT. "Exfoliative cytopathologic studies in organ transplantation. 3. The cytologic profile of urine during acute renal allograft rejection." Acta Cytol 14, no. 4 (April 1970): 176-181. Link to Item
  - Bossen, EH, Johnston, WW, Amatulli, J, and Rowlands, DT. "Exfoliative cytopathologic studies in organ transplantation. I. The cytologic diagnosis of cytomegalic inclusion disease in the urine of renal allograft recipients." Am J Clin Pathol 52, no. 3 (September 1969): 340-344. Link to Item
  - Rowlands, DT, and Bossen, EH. "Immunological mechanisms of allograft rejection." Arch Intern Med 123, no. 5 (May 1969): 491-500. (Review) Link to Item
- Book Sections
  - Bossen, EH. "Muscular disorders." In Garner and Klintworth's Pathobiology of Ocular Disease Part B, Third Edition, 1531-1566. January 1, 2007.
- Other Articles
  - Perry, BP, Scher, RL, Gray, L, Bossen, EH, and Tucci, DL. "Pathologic quiz case 1. Salivary gland choristoma of the middle ear." Arch Otolaryngol Head Neck Surg 124, no. 6 (June 1998): 714-716. Link to Item
- Conference Papers
  - Ha, CI, Desai, AK, Waterfield, J, Kazi, ZB, Austin, SL, Bossen, EH, Kishnani, PS, and Buckley, AF. "Outside the fiber: interstitial pathology of skeletal muscle in infantile Pompe disease." January 2017. Full Text
  - Sankari, MR, and Bossen, EH. "Chronic pancreatitis with pancreatic rheumatoid nodules." October 2004. Link to Item
  - Luna, A, Martinez, SJ, and Bossen, EH. "Magnetic resonance (MR) imaging of intramuscular myxoma (IM) with histological correlation." November 2000. Link to Item
  - GARCIA, JA, WOLF, HK, and BOSSEN, EH. "ONCOCYTIC DIFFERENTIATION IN INTRAHEPATIC BILIARY CYSTADENOCARCINOMA." February 26, 1992. Link to Item
  - WAIN, SL, VOLLMER, RT, SHELBURNE, JD, KIER, R, and BOSSEN, EH. "BASALOID-SQUAMOUS CARCINOMA OF THE TONGUE, HYPOPHARYNX, AND LARYNX - A REPORT OF 10 CASES." March 1986. Link to Item
  - ASHTON, PR, JOHNSTON, WW, and BOSSEN, EH. "PLANIMETRIC EVALUATION OF SMALL-CELL CARCINOMA OF THE LUNG." 1983. Link to Item
  - SZPAK, CA, WOODARD, BH, and BOSSEN, EH. "NEUROENDOCRINE CARCINOMA OF THE SKIN - ULTRASTRUCTURAL CONTRAST WITH OAT-CELL CARCINOMA." 1981. Link to Item
  - ROHLFING, MB, BOSSEN, EH, GALLAGHER, JJ, and JENNINGS, RB. "ULTRASTRUCTURE OF THE MYOCARDIUM IN KEARNS-SAYRE SYNDROME." 1980. Link to Item
  - JOHNSTON, WW, and BOSSEN, EH. "COMPARISON BETWEEN CYTOPATHOLOGY AND HISTOPATHOLOGY IN TYPING OF LUNG-CANCER." 1977. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers