Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Assistant Professor, Pathology, Duke University 1972 - 1983
  • Associate Professor, Pathology, Dartmouth College 1976 - 1980
  • Fellow, Pathology, Duke University 1968 - 1970
  • Resident, Pathology, Duke University 1966 - 1968
  • Intern, Pathology, Duke University 1965 - 1966
  • M.D., Duke University 1965
  • B.S., University of Florida 1961
• 

  Duke Appointment History

  • Professor of Pathology, Pathology, Clinical Science Departments 1980 - 2012
  • Associate Professor of Pathology, Pathology, Clinical Science Departments 1976 - 1980
  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 1972 - 1976
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Mori, Mari, Jennifer Goldstein, Sarah P. Young, Edward H. Bossen, John Shoffner, and Dwight D. Koeberl. “Complex III deficiency due to an in-frame MT-CYB deletion presenting as ketotic hypoglycemia and lactic acidosis..” Mol Genet Metab Rep 4 (September 2015): 39–41. https://doi.org/10.1016/j.ymgmr.2015.06.001.
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    • Buckley, Anne F., and Edward H. Bossen. “Skeletal muscle microvasculature in the diagnosis of neuromuscular disease..” J Neuropathol Exp Neurol 72, no. 10 (October 2013): 906–18. https://doi.org/10.1097/NEN.0b013e3182a7f0b8.
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    • Thurberg, Beth L., Colleen Lynch Maloney, Charles Vaccaro, Kendra Afonso, Anne Chun-Hui Tsai, Edward Bossen, Priya S. Kishnani, and Michael O’Callaghan. “Characterization of pre- and post-treatment pathology after enzyme replacement therapy for Pompe disease..” Lab Invest 86, no. 12 (December 2006): 1208–20. https://doi.org/10.1038/labinvest.3700484.
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    • Luna, A., S. Martinez, and E. Bossen. “Magnetic resonance imaging of intramuscular myxoma with histological comparison and a review of the literature..” Skeletal Radiol 34, no. 1 (January 2005): 19–28. https://doi.org/10.1007/s00256-004-0848-9.
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    • Lansford, Christopher D., Edward H. Bossen, and Richard L. Scher. “Pathology quiz case 1. Hairy polyp..” Arch Otolaryngol Head Neck Surg 129, no. 3 (March 2003): 369–71.
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    • Tim, R. W., J. R. Gilbert, J. M. Stajich, E. Rampersaud, K. D. Viles, R. Tawil, G. W. Padberg, et al. “Clinical Studies in Non-chromosome 4-Linked Facioscapulohumeral Muscular Dystrophy..” J Clin Neuromuscul Dis 3, no. 1 (September 2001): 1–7.
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    • Amalfitano, A., A. R. Bengur, R. P. Morse, J. M. Majure, L. E. Case, D. L. Veerling, J. Mackey, et al. “Recombinant human acid alpha-glucosidase enzyme therapy for infantile glycogen storage disease type II: results of a phase I/II clinical trial..” Genet Med 3, no. 2 (March 2001): 132–38.
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    • Bettencourt, M. S., C. S. Burton, V. G. Prieto, E. H. Bossen, and C. R. Shea. “Recurrent papules on the left upper extremity of a 50-year-old man..” Arch Dermatol 137, no. 3 (March 2001): 365–70.
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    • Bettencourt, M. S., C. S. Burton, V. G. Prieto, E. H. Bossen, and C. R. Shea. “Recurrent papules on the left upper extremity of a 50-year-old man - Epithelioid hemangioendothelioma (EHE).” Archives of Dermatology 137, no. 3 (March 1, 2001): 365-+.
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    • Morse, M. A., E. Bossen, T. A. D’Amico, W. Williamson, and R. Johnson. “Myxoid liposarcoma of the supraclavicular fossa..” Chest 117, no. 5 (May 2000): 1518–20. https://doi.org/10.1378/chest.117.5.1518.
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    • O’Grady, M., A. C. Hackney, K. Schneider, E. Bossen, K. Steinberg, J. M. D. Jr, W. J. Murray, and W. D. Watkins. “Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle.” Medicine and Science in Sports and Exercise 32, no. 7 (2000): 1191–96.
    • Mooney, E. E., L. G. Dodd, R. T. Vollmer, and E. H. Bossen. “Fine-needle aspiration biopsy diagnosis of primary bronchial basaloid-squamous carcinoma..” Diagn Cytopathol 16, no. 2 (February 1997): 187–88.
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    • Kishnani, P. S., J. L. Van Hove, J. S. Shoffner, A. Kaufman, E. H. Bossen, and S. G. Kahler. “Acute pancreatitis in an infant with lactic acidosis and a mutation at nucleotide 3243 in the mitochondrial DNA tRNALeu(UUR) gene..” Eur J Pediatr 155, no. 10 (October 1996): 898–903.
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    • Van Hove, J. L., S. Shanske, F. Ciacci, S. Ballinger, J. S. Shoffner, D. C. Wallace, T. Hanioka, K. Folkers, E. H. Bossen, and P. S. Kussin. “Mitochondrial myopathy with anemia, cardiomyopathy, and lactic acidosis: a distinct late onset mitochondrial disorder..” Am J Med Genet 51, no. 2 (June 1, 1994): 114–20. https://doi.org/10.1002/ajmg.1320510207.
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    • Acker, J. C., E. H. Bossen, and E. C. Halperin. “The management of desmoid tumors..” Int J Radiat Oncol Biol Phys 26, no. 5 (August 1, 1993): 851–58. https://doi.org/10.1016/0360-3016(93)90501-l.
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    • Dresser, L. P., E. W. Massey, E. E. Johnson, and E. Bossen. “Ipecac myopathy and cardiomyopathy..” J Neurol Neurosurg Psychiatry 56, no. 5 (May 1993): 560–62. https://doi.org/10.1136/jnnp.56.5.560.
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    • Chaopricha, W., L. E. Chen, A. V. Seaber, E. Bossen, and J. R. Urbaniak. “Micro-anastomosis of 0.3-0.4 mm vessels after cold ischemia using a rat model of toe-to-thumb transplantation..” Microsurgery 14, no. 9 (1993): 619–23.
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    • Wolf, H. K., J. A. Garcia, and E. H. Bossen. “Oncocytic differentiation in intrahepatic biliary cystadenocarcinoma..” Mod Pathol 5, no. 6 (November 1992): 665–68.
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    • Tharrington, C. L., and E. H. Bossen. “Nasopharyngeal teratomas..” Arch Pathol Lab Med 116, no. 2 (February 1992): 165–67.
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    • Herzberg, A. J., E. H. Bossen, and P. J. Walther. “Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management..” Cancer 68, no. 5 (September 1, 1991): 1015–20. https://doi.org/10.1002/1097-0142(19910901)68:5<1015::aid-cncr2820680518>3.0.co;2-z.
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    • Chen, L. E., A. V. Seaber, E. Bossen, and J. R. Urbaniak. “The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model..” J Orthop Res 9, no. 2 (March 1991): 266–74. https://doi.org/10.1002/jor.1100090215.
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    • Hug, G., G. Chuck, Y. T. Chen, H. H. Kay, and E. H. Bossen. “Chorionic villus ultrastructure in type II glycogen storage disease (Pompe's disease).” N Engl J Med 324, no. 5 (January 31, 1991): 342–43. https://doi.org/10.1056/NEJM199101313240517.
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    • Sommer, J. R., E. Bossen, H. Dalen, P. Dolber, T. High, P. Jewett, E. A. Johnson, J. Junker, S. Leonard, and R. Nassar. “To excite a heart: a bird's view..” Acta Physiol Scand Suppl 599 (1991): 5–21.
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    • Friedman, H. S., O. M. Colvin, K. Aisaka, J. Popp, E. H. Bossen, K. A. Reimer, J. B. Powell, J. Hilton, S. S. Gross, and R. Levi. “Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity..” Cancer Res 50, no. 8 (April 15, 1990): 2455–62.
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    • Wolf, H. K., J. M. Harrelson, and E. H. Bossen. “Multicentric malignant fibrous histiocytoma of soft tissue..” Am J Surg Pathol 14, no. 2 (February 1990): 188–93.
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    • Benning, T. L., and E. H. Bossen. “Multilammelated structures in muscle external lamina..” Ultrastruct Pathol 13, no. 1 (January 1989): 83–88.
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    • Krendel, D. A., J. M. Gilchrist, and E. H. Bossen. “Distal vacuolar myopathy with complete heart block..” Arch Neurol 45, no. 6 (June 1988): 698–99.
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    • Bossen, E. H. “Heterotopic brain tissue..” Am J Surg Pathol 12, no. 1 (January 1988).
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    • Bossen, E. H., and W. R. Hudson. “Oligodendroglioma arising in heterotopic brain tissue of the soft palate and nasopharynx..” Am J Surg Pathol 11, no. 7 (July 1987): 571–74.
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    • Krendel, D. A., J. M. Gilchrist, A. O. Johnson, and E. H. Bossen. “Isolated deficiency of vitamin E with progressive neurologic deterioration..” Neurology 37, no. 3 (March 1987): 538–40. https://doi.org/10.1212/wnl.37.3.538.
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    • BOSSEN, E. H. “Oligodendroglioma arising in heterotopic brain tissue of the soft palate and nasopharynx..” Am J Surg Pathol 11 (1987): 571–74. https://doi.org/10.1097/00000478-198801000-00009.
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    • Wain, S. L., R. Kier, R. T. Vollmer, and E. H. Bossen. “Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases..” Hum Pathol 17, no. 11 (November 1986): 1158–66.
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    • Borowitz, M. J., M. A. Weiss, E. H. Bossen, and R. S. Metzgar. “Characterization of renal neoplasms with monoclonal antibodies to leukocyte differentiation antigens..” Cancer 57, no. 2 (January 15, 1986): 251–56. https://doi.org/10.1002/1097-0142(19860115)57:2<251::aid-cncr2820570211>3.0.co;2-a.
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    • Estrada, J. C., N. T. Brinn, and E. H. Bossen. “A rapid method of staining ultrathin sections for surgical pathology TEM with the use of the microwave oven..” Am J Clin Pathol 83, no. 5 (May 1985): 639–41. https://doi.org/10.1093/ajcp/83.5.639.
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    • Silverman, P. M., E. H. Bossen, S. R. Fisher, T. B. Cole, M. Korobkin, and R. A. Halvorsen. “Carcinoma of the larynx and hypopharynx: computed tomographic-histopathologic correlations..” Radiology 151, no. 3 (June 1984): 697–702. https://doi.org/10.1148/radiology.151.3.6718729.
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    • Szpak, C. A., E. H. Bossen, J. Linder, and W. W. Johnston. “Cytomorphology of primary small-cell (Merkel-cell) carcinoma of the skin in fine needle aspirates..” Acta Cytol 28, no. 3 (May 1984): 290–96.
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    • Bossen, E. H., and J. R. Sommer. “Comparative stereology of the lizard and frog myocardium..” Tissue Cell 16, no. 2 (1984): 173–78.
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    • Croker, B. P., E. H. Bossen, N. T. Brinn, and F. A. Hammond. “A fixative for use in muscle histochemistry..” J Histochem Cytochem 31, no. 1 (January 1983): 110–12. https://doi.org/10.1177/31.1.6187797.
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    • Alexander, C. B., B. P. Croker, and E. H. Bossen. “Dermatomyositis associated with IgA deposition..” Arch Pathol Lab Med 106, no. 9 (September 1982): 449–51.
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    • Hamilton, C. W., J. D. Shelburne, E. H. Bossen, and J. E. Lowe. “A glomus tumor of the jejunum masquerading as a carcinoid tumor..” Hum Pathol 13, no. 9 (September 1982): 859–61.
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    • Metzgar, R. S., M. T. Gaillard, S. J. Levine, F. L. Tuck, E. H. Bossen, and M. J. Borowitz. “Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies..” Cancer Res 42, no. 2 (February 1982): 601–8.
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    • Johnson, D. G., D. Osborne, and E. H. Bossen. “Case report 185: metastasis to the femur from a bronchial carcinoid tumor..” Skeletal Radiol 7, no. 4 (January 1982): 293–95.
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    • Sommer, J. R., E. Bossen, and A. Fabiato. “JUNCTIONAL SARCOPLASMIC RETICULUM IN EXCITATION-CONTRACTION-COUPLING..” Proceedings  Electron Microscopy Society of America, 1982, 136–37.
    • Johnston, W. W., and E. H. Bossen. “Ten years of respiratory cytopathology at Duke University Medical Center. II. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, with a comparison between cytopathology and histopathology in the typing of lung cancer..” Acta Cytol 25, no. 5 (September 1981): 499–505.
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    • Johnston, W. W., and E. H. Bossen. “Ten years of respiratory cytopathology at Duke University Medical Center. I. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, noting the significance of specimen number and type..” Acta Cytol 25, no. 2 (March 1981): 103–7.
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    • Bossen, E. H., J. R. Sommer, and R. A. Waugh. “Comparative stereology of mouse atria..” Tissue Cell 13, no. 1 (1981): 71–77.
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    • JOHNSTON, W. W., and E. H. BOSSEN. “10 YEARS OF RESPIRATORY CYTO-PATHOLOGY AT DUKE-UNIVERSITY MEDICAL-CENTER .2. THE CYTOPATHOLOGIC DIAGNOSIS OF LUNG-CANCER DURING THE YEARS 1970 TO 1974, WITH A COMPARISON BETWEEN CYTO-PATHOLOGY AND HISTOPATHOLOGY IN THE TYPING OF LUNG-CANCER.” Acta Cytologica 25, no. 5 (January 1, 1981): 499–505.
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    • JOHNSTON, W. W., and E. H. BOSSEN. “10 YEARS OF RESPIRATORY CYTO-PATHOLOGY AT DUKE-UNIVERSITY-MEDICAL-CENTER .1. THE CYTOPATHOLOGIC DIAGNOSIS OF LUNG-CANCER DURING THE YEARS 1970 TO 1974, NOTING THE SIGNIFICANCE OF SPECIMEN NUMBER AND TYPE.” Acta Cytologica 25, no. 2 (January 1, 1981): 103–7.
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    • Carson, K. A., E. H. Bossen, and J. S. Hanker. “Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes..” Neuropathol Appl Neurobiol 6, no. 5 (September 1980): 361–74.
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    • Hanker, J. S., W. W. Ambrose, C. J. James, J. Mandelkorn, P. E. Yates, S. A. Gall, E. H. Bossen, J. W. Fay, J. Laszlo, and J. O. Moore. “Facilitated light microscopic cytochemical diagnosis of acute myelogenous leukemia..” Cancer Res 39, no. 5 (May 1979): 1635–39.
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    • Alexander, C. B., and E. H. Bossen. “Peripheral couplings in human skeletal muscle..” Lab Invest 39, no. 1 (July 1978): 17–20.
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    • Soules, M. R., G. E. Abraham, and E. H. Bossen. “The steroid profile of a virilizing ovarian tumor..” Obstet Gynecol 52, no. 1 (July 1978): 73–78.
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    • Michel, R. G., B. H. Woodard, J. D. Shelburne, and E. H. Bossen. “Ceruminous gland adenocarcinoma: a light and electron microscopic study..” Cancer 41, no. 2 (February 1978): 545–53. https://doi.org/10.1002/1097-0142(197802)41:2<545::aid-cncr2820410222>3.0.co;2-w.
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    • Bossen, E. H., J. R. Sommer, and R. A. Waugh. “Comparative stereology of the mouse and finch left ventricle..” Tissue Cell 10, no. 4 (1978): 773–84.
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    • Bossen, E. H., and W. W. Johnston. “Exfoliative cytopathologic studies in organ transplantation. V. The diagnosis of rejection in the immediate postoperative period..” Acta Cytol 21, no. 4 (July 1977): 502–7.
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    • Gold, J. H., J. D. Shelburne, and E. H. Bossen. “Meningeal mycosis fungoides: cytologic and ultrastructural aspects..” Acta Cytol 20, no. 4 (July 1976): 349–55.
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    • Gold, J. H., and E. H. Bossen. “Benign vaginal rhabdomyoma: a light and electron microscopic study..” Cancer 37, no. 5 (May 1976): 2283–94. https://doi.org/10.1002/1097-0142(197605)37:5<2283::aid-cncr2820370519>3.0.co;2-5.
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    • Bossen, E. H., and W. W. Johnston. “Exfoliative cytopathologic studies in organ transplantation IV. The cytologic diagnosis of herpesvirus in the urine of renal allograft recipients..” Acta Cytol 19, no. 5 (September 1975): 415–19.
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    • Bossen, E. H., J. D. Shelburne, and B. S. Verkauf. “Respiratory muscle involvement in infantile myotonic dystrophy..” Arch Pathol 97, no. 4 (April 1974): 250–52.
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    • Ilgen, C. L., E. H. Bossen, D. T. Rowlands, and P. M. Burkholder. “Isolation and characterization of C4-synthesizing cells from guinea-pig spleen..” Immunology 26, no. 3 (March 1974): 659–65.
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    • Bossen, E. H. “Myofiber inclusions..” Am J Clin Pathol 59, no. 5 (May 1973). https://doi.org/10.1093/ajcp/59.5.763.
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    • Bossen, E. H., J. W. Lough, and J. L. Hansen. “The effects of chloroquine on chick skeletal muscle in vitro..” Toxicol Appl Pharmacol 24, no. 2 (February 1973): 197–205.
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    • Lough, J. W., M. L. Entman, E. H. Bossen, and J. L. Hansen. “Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture..” J Cell Physiol 80, no. 3 (December 1972): 431–36. https://doi.org/10.1002/jcp.1040800313.
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    • Bossen, E. H., and D. T. Rowlands. “Localization of functionally different guinea-pig spleen cells in albumin gradients..” Immunology 22, no. 3 (March 1972): 417–21.
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    • Rowlands, D. T., P. M. Burkholder, E. H. Bossen, and H. H. Lin. “Renal allografts in HL-A matched recipients. Light, immunofluorescence and electron microscopic studies..” Am J Pathol 61, no. 2 (November 1970): 177–210.
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    • Bossen, E. H., W. W. Johnston, J. Amatulli, and D. T. Rowlands. “Exfoliative cytopathologic studies in organ transplantation. 3. The cytologic profile of urine during acute renal allograft rejection..” Acta Cytol 14, no. 4 (April 1970): 176–81.
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    • Bossen, E. H., W. W. Johnston, J. Amatulli, and D. T. Rowlands. “Exfoliative cytopathologic studies in organ transplantation. I. The cytologic diagnosis of cytomegalic inclusion disease in the urine of renal allograft recipients..” Am J Clin Pathol 52, no. 3 (September 1969): 340–44. https://doi.org/10.1093/ajcp/52.3.340.
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    • Rowlands, D. T., and E. H. Bossen. “Immunological mechanisms of allograft rejection..” Arch Intern Med 123, no. 5 (May 1969): 491–500.
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  • Book Sections

    • Bossen, E. H. “Muscular disorders.” In Garner and Klintworth’s Pathobiology of Ocular Disease Part B, Third Edition, 1531–66, 2007.

  • Other Articles

    • Perry, B. P., R. L. Scher, L. Gray, E. H. Bossen, and D. L. Tucci. “Pathologic quiz case 1. Salivary gland choristoma of the middle ear..” Arch Otolaryngol Head Neck Surg, June 1998.
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  • Conference Papers

    • Ha, Christine I., Ankit K. Desai, Justin Waterfield, Zoheb B. Kazi, Stephanie L. Austin, Edward H. Bossen, Priya S. Kishnani, and Anne F. Buckley. “Outside the fiber: interstitial pathology of skeletal muscle in infantile Pompe disease.” In Molecular Genetics and Metabolism, 120:S60–61. Elsevier BV, 2017. https://doi.org/10.1016/j.ymgme.2016.11.136.
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    • Sankari, M. R., and E. H. Bossen. “Chronic pancreatitis with pancreatic rheumatoid nodules.” In American Journal of Gastroenterology, 99:S129–30. BLACKWELL PUBLISHING INC, 2004.
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    • Luna, A., S. J. Martinez, and E. H. Bossen. “Magnetic resonance (MR) imaging of intramuscular myxoma (IM) with histological correlation.” In Radiology, 217:272–73. RADIOLOGICAL SOC NORTH AMER, 2000.
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    • GARCIA, J. A., H. K. WOLF, and E. H. BOSSEN. “ONCOCYTIC DIFFERENTIATION IN INTRAHEPATIC BILIARY CYSTADENOCARCINOMA.” In Faseb Journal, 6:A1071–A1071. FEDERATION AMER SOC EXP BIOL, 1992.
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    • WAIN, S. L., R. T. VOLLMER, J. D. SHELBURNE, R. KIER, and E. H. BOSSEN. “BASALOID-SQUAMOUS CARCINOMA OF THE TONGUE, HYPOPHARYNX, AND LARYNX - A REPORT OF 10 CASES.” In American Journal of Clinical Pathology, 85:383–383. LIPPINCOTT-RAVEN PUBL, 1986.
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    • ASHTON, P. R., W. W. JOHNSTON, and E. H. BOSSEN. “PLANIMETRIC EVALUATION OF SMALL-CELL CARCINOMA OF THE LUNG.” In Acta Cytologica, 27:557–557. SCI PRINTERS & PUBL INC, 1983.
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    • SZPAK, C. A., B. H. WOODARD, and E. H. BOSSEN. “NEUROENDOCRINE CARCINOMA OF THE SKIN - ULTRASTRUCTURAL CONTRAST WITH OAT-CELL CARCINOMA.” In Laboratory Investigation, 44:A65–A65. WILLIAMS & WILKINS, 1981.
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    • ROHLFING, M. B., E. H. BOSSEN, J. J. GALLAGHER, and R. B. JENNINGS. “ULTRASTRUCTURE OF THE MYOCARDIUM IN KEARNS-SAYRE SYNDROME.” In Laboratory Investigation, 42:146–146. WILLIAMS & WILKINS, 1980.
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    • JOHNSTON, W. W., and E. H. BOSSEN. “COMPARISON BETWEEN CYTOPATHOLOGY AND HISTOPATHOLOGY IN TYPING OF LUNG-CANCER.” In Acta Cytologica, 21:784–784. SCI PRINTERS & PUBL INC, 1977.
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