Eric Leo Eisenstein

Journal article JACC Cardiovasc Interv · December 2009 Featured Publication OBJECTIVES: The aim of this study was to assess, after 2 years of follow-up, the safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent (ZES) compared with a paclitaxel-eluting stent (PES) in patients with native coronary lesions. BACKGROU ... Full text Link to item Cite

Long-term clinical and economic analysis of the Endeavor drug-eluting stent versus the Driver bare-metal stent: 4-year results from the ENDEAVOR II trial (Randomized Controlled Trial to Evaluate the Safety and Efficacy of the Medtronic AVE ABT-578 Eluting Driver Coronary Stent in De Novo Native Coronary Artery Lesions).

Journal article JACC Cardiovasc Interv · December 2009 Featured Publication OBJECTIVES: This study was designed to evaluate long-term clinical and economic outcomes for subjects receiving Endeavor drug-eluting versus Driver bare-metal stents (both Medtronic CardioVascular, Santa Rosa, California). BACKGROUND: Early studies found t ... Full text Link to item Cite

Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions).

Journal article JACC Cardiovasc Interv · December 2009 Featured Publication OBJECTIVES: The aim of this study was to evaluate clinical and economic outcomes for subjects receiving zotarolimus-eluting (ZES) (n = 323) versus sirolimus-eluting stents (SES) (n = 113) in the ENDEAVOR III (Randomized Controlled Trial of the Medtronic En ... Full text Link to item Cite

Do income level and race influence survival in patients receiving hemodialysis?

Journal article Am J Med · February 2009 Featured Publication BACKGROUND: Residence in a lower-income area has been associated with higher mortality among patients receiving dialysis. We sought to determine whether these differences persist and whether the effect of income-area on mortality is different for African A ... Full text Link to item Cite

A randomized clinical trial of clinical decision support in a rural community health network serving lower income individuals: study design and baseline characteristics.

Journal article Stud Health Technol Inform · 2009 Featured Publication Lower income individuals in the US frequently experience difficulties in obtaining access to needed health care services. We describe a randomized clinical trial that seeks to improve the quality of, and access to healthcare services for medically underser ... Link to item Cite

Re-evaluating the volume-outcome relationship in hemodialysis patients.

Journal article Health Policy · December 2008 Featured Publication OBJECTIVES: We sought to determine whether dialysis patient mortality rates are associated with differences in dialysis facility size, and whether this relationship differs among higher risk diabetic and lower-risk non-diabetic patients. METHODS: Using 186 ... Full text Link to item Cite

Long-term clinical outcomes following coronary stenting.

Journal article Arch Intern Med · August 11, 2008 Featured Publication BACKGROUND: Clinical trials of drug-eluting stents (DES) vs bare metal stents (BMS) report a reduced need for target lesion revascularization with no difference in death or myocardial infarction. However, these trials selectively enrolled patients with low ... Full text Link to item Cite

Sensible approaches for reducing clinical trial costs.

Journal article Clin Trials · 2008 Featured Publication BACKGROUND: Over the past decade, annual funding for biomedical research has more than doubled while new molecular entity approvals have declined by one third. OBJECTIVE: To assess the value of practices commonly employed in the conduct of large-scale clin ... Full text Link to item Cite

Evaluating implementation fidelity in health information technology interventions.

Journal article AMIA Annu Symp Proc · October 11, 2007 Featured Publication Health information technology evaluators need to distinguish between intervention efficacy as assessed in the ideal circumstances of clinical trials and intervention effectiveness as assessed in the real world circumstances of actual practice. Because curr ... Link to item Cite

Economic return of clinical trials performed under the pediatric exclusivity program.

Journal article JAMA · February 7, 2007 Featured Publication CONTEXT: In 1997, Congress authorized the US Food and Drug Administration (FDA) to grant 6-month extensions of marketing rights through the Pediatric Exclusivity Program if industry sponsors complete FDA-requested pediatric trials. The program has been pra ... Full text Open Access Link to item Cite

Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.

Journal article JAMA · January 10, 2007 Featured Publication CONTEXT: Recent studies of drug-eluting intracoronary stents suggest that current antiplatelet regimens may not be sufficient to prevent late stent thrombosis. OBJECTIVE: To assess the association between clopidogrel use and long-term clinical outcomes of ... Full text Link to item Cite

What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial.

Journal article J Card Fail · June 2006 Featured Publication BACKGROUND: The Digitalis Investigation Group (DIG) clinical train randomized 6800 congestive heart failure patients (ejection fraction > or =45%) to a daily regimen of either digoxin or placebo. At 37 months average follow-up, patients in both groups had ... Full text Link to item Cite

Conducting an economic analysis to assess the electrocardiogram's value.

Journal article J Electrocardiol · April 2006 Featured Publication BACKGROUND AND PURPOSE: Health economic analyses seek to assess the relative value (cost vs health benefit trade-offs) of medical technologies. However, these methods have been underused in studies of the electrocardiogram (ECG). METHODS: We develop a fram ... Full text Link to item Cite

Assessing the quality of medical information technology economic evaluations: room for improvement.

Journal article AMIA Annu Symp Proc · 2006 Featured Publication Medical information systems are being recognized for their ability to improve patient outcomes. While standards for the economic evaluation of medical technologies were instituted in the mid-1990s, little is known about their application in medical informa ... Link to item Cite

Elevated body mass index and intermediate-term clinical outcomes after acute coronary syndromes.

Journal article Am J Med · September 2005 Featured Publication PURPOSE: Obesity is a coronary disease risk factor, but its independent effect on clinical outcomes following acute coronary syndromes has not been quantified. We evaluated the relationship between elevated body mass index (BMI) and 30-day, 90-day, and 1-y ... Full text Link to item Cite

Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II.

Journal article Ann Intern Med · April 19, 2005 Featured Publication BACKGROUND: The Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II demonstrated that implantable cardioverter defibrillators (ICDs) save lives when used in patients with a history of myocardial infarction (MI) and an ejection fraction of 0.3 ... Full text Link to item Cite

Reducing the costs of phase III cardiovascular clinical trials.

Journal article Am Heart J · March 2005 Featured Publication BACKGROUND: The pharmaceutical industry spends approximately 26.4 billion dollars annually for research and development (4.1 billion dollars in cardiovascular products). We compared pharmaceutical companies' planned resource use and costs in Phase III card ... Full text Link to item Cite

Assessing the potential economic value of health information technology interventions in a community-based health network.

Journal article AMIA Annu Symp Proc · 2005 Featured Publication Health information professionals recognize the need to demonstrate that the benefits of health information technological (HIT) interventions outweigh their costs. However, such cost-benefit analyses are rarely conducted for HIT interventions, due in part t ... Link to item Cite

Vasopeptidase inhibitor reduces inhospital costs for patients with congestive heart failure: results from the IMPRESS trial. Inhibition of Metallo Protease by BMS-186716 in a Randomized Exercise and Symptoms Study in Subjects With Heart Failure.

Journal article Am Heart J · June 2002 Featured Publication BACKGROUND: The Inhibition of Metallo Protease by BMS-186716 in a Randomized Exercise and Symptoms Study in Subjects With Heart Failure (IMPRESS) clinical trial randomized patients with congestive heart failure to a daily regimen of either omapatrilat or l ... Full text Link to item Cite

Assessing the clinical and economic burden of coronary artery disease: 1986-1998.

Journal article Med Care · August 2001 Featured Publication BACKGROUND: The acute phase of coronary artery disease (CAD) is dramatic and receives much attention because of its high mortality and associated treatment cost. However, the acute phase typically resolves within 30 days whereas CAD is a chronic disease, w ... Full text Link to item Cite

Cost effectiveness of early discharge after uncomplicated acute myocardial infarction.

Journal article N Engl J Med · March 16, 2000 Featured Publication BACKGROUND: Reducing the length of hospitalizations can reduce short-term costs, but there are few data on the long-term clinical and economic consequences of early discharge. METHODS: Using data from the Global Utilization of Streptokinase and Tissue Plas ... Full text Link to item Cite

An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial.

Journal article Ann Emerg Med · January 2000 Featured Publication STUDY OBJECTIVE: Conventional emergency department testing strategies for patients with chest pain often do not provide unequivocal diagnosis of acute coronary syndromes. This study was conducted to determine whether the routine use of single photon emissi ... Full text Link to item Cite

An evaluation of factors influencing Bayesian learning systems.

Journal article J Am Med Inform Assoc · 1994 Featured Publication OBJECTIVES: To examine the influences of situational and model factors on the accuracy of Bayesian learning systems. DESIGN: This study examines the impacts of variations in two situational factors, training sample size and number of attributes, and in two ... Full text Link to item Cite