Overview
The incorporation of personalized medicine to all areas of human health represents a turning point for human genetics studies, a point at which the discoveries made have real implications for clinical medicine. It is important for students to gain experience in how human genetics studies are conducted and how results of those studies may be used. As a statistical geneticist and biostatistician my research interests are focused on developing and applying statistical methods to search for genes causing common human diseases. My research programs combine development and application of statistical methods for genetic studies, with a particular emphasis on understanding the joint effects of genes and environment.
These studies I work on cover diverse areas in biomedicine but are always collaborative, with the goal of bringing robust data science and statistical methods to the project. Collaborative studies include genetic and ‘omics studies of cardiovascular disease, health effects of air pollution, genetic analysis of adherence to an exercise program, genetic analysis in evaluating colon cancer risk, genetic analysis of suicide, and systems biology analysis of Gulf War Illness.
Keywords: human genetics, genetic association, gene mapping, genetic epidemiology, statistical genetics, biostatistics, cardiovascular disease, computational biology, diabetes, aging, colon cancer, colon polyps, kidney disease, Gulf War Illness, exercise behavior, suicide
Current Duke Appointments & Affiliations
Recent Scholarly Works
Cross-Ancestry and Phenome-Wide Associations of Cancer-Specific Polygenic Risk Scores.
Journal article JCO Precis Oncol · September 2026 PURPOSE: Genome-wide association studies have identified many common variants associated at low effect sizes with various cancers. Summing the effects of these variants into polygenic risk scores (PRS) can improve cancer risk prediction. However, cross-can ... Full text Link to item CiteToxic exposure and rates of suicidal thoughts and behaviors among U.S. military veterans.
Journal article Psychiatry Res · August 2026 Exposure to toxic substances has been linked to poorer mental health among U.S. military veterans broadly, but less is known about specific psychiatric outcomes, such as suicidal thoughts and behaviors (STBs). In the current observational cohort study, we ... Full text Link to item CiteAn Evaluation of the Complex Relationship between Combat Experiences and Suicide Deaths, Suicide Attempts, and Suicidal Ideation among U.S. Military Veterans.
Journal article Arch Suicide Res · June 23, 2026 OBJECTIVE: Combat has been related to suicidal thoughts and behaviors via increased PTSD and depression in prior work; however, such studies have been limited by sample size, reliance on self-report, failure to account for other disorders, and a limited fo ... Full text Link to item CiteRecent Grants
Computational Biology and Bioinformatics Training Grant
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
ResearchCo-Mentor · Awarded by National Institute on Aging · 2024 - 2029View All Grants